HeartHistone proteins are nuclear proteins which interact with DNA, condense and provide structure to chromosomes.  Histones are prone to several post-translational modifications (PTMs). By modifying amino acid residues on the tail of the core histones it is possible to alter the availability of the DNA to interact with other nuclear proteins.

Histone proteins are nuclear proteins which interact with DNA, condense and provide structure to chromosomes.  Histones are prone to several post-translational modifications (PTMs). By modifying amino acid residues on the tail of the core histones it is possible to alter the availability of the DNA to interact with other nuclear proteins. PTMs of Histone tails include: methylation, acetylation, phosphorylation, ubiquitination, sumoylation, citrullination and ADP-ribosylation.  Histone PTMs play a role in gene regulation, DNA repair and chromosome condensation during cell division.  To learn more, view our Modified Histone Map poster or request a copy here. Novus provides a line of multi-assay validated modified histone antibodies called Epi-Plus antibodies. Learn more about Epi-Plus here.

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