53BP1 Products

Antibodies
53BP1 Antibody
53BP1 Antibody
Species: Hu, Mu, Rt, Fi, Gt, Pm
Applications: WB, ChIP, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Host: Rabbit Polyclonal
53BP1 Antibody
53BP1 Antibody
NB100-305
Species: Hu, Mu, Rt
Applications: WB, ChIP, ICC/IF, IHC, IHC-Fr, IHC-P, PLA
Host: Rabbit Polyclonal
53BP1 Antibody (1285C)
53BP1 Antibody (1285C)
NBP2-54753
Species: Hu, Mu, Rt, Po, Bv, Ca, Eq, Fe, Pm
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Monoclonal
Antibody Packs
53BP1 Antibody Pack
53BP1 Antibody Pack
NB100-926
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC
Host: Rabbit
Lysates
53BP1 Overexpression Lysate ( ...
53BP1 Overexpression Lysate (Native)
NBP2-10450
Applications: WB
Proteins
Recombinant Human 53BP1 Prote ...
Recombinant Human 53BP1 Protein
H00007158-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
53BP1 RNAi
53BP1 RNAi
H00007158-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Tumor suppressor p53-binding protein 1 (53BP1) is a key protein for tumor suppression by coordinating the cellular response to DNA damage. Upon DNA damage, 53BP1 is activated by ATM Kinase phosphorylation and relocalizes to the presumptive sites of damage, specifically, double-strand breaks. This suggests that 53BP1 may also play a role in maintaining genomic stability.

53BP1 antibodies are very useful tools for cancer studies and research into DNA repair mechanisms.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Product By Gene ID 7158
Alternate Names
  • 53BP1
  • tumor suppressor p53-binding protein 1
  • p53-binding protein 1
  • tumor protein 53-binding protein, 1
  • tumor protein p53-binding protein, 1
  • MGC138366
  • p202
  • p53BP1,53BP1FLJ41424
  • tumor protein p53 binding protein 1

Research Areas for 53BP1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Checkpoint signaling
DNA Double Strand Break Repair
DNA Repair
Phospho-Specific
Tumor Suppressors

Bioinformatics Tool for 53BP1

Discover related pathways, diseases and genes to 53BP1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related 53BP1 Blog Posts

Check out the latest blog posts on 53BP1.
The recent relationship of BRCA1 and 53BP1
The p53-binding protein 1 (53BP1) is a DNA damage response factor, which is recruited to nuclear structures at the site of DNA damage.  DNA double-strand breaks (DSBs) are mutations that are detrimental to cell viability and genome stability, and m...    Read more.
53BP1 - a marker for DNA Double Strand Break
53BP1 (p53 binding protein 1) was originally thought to be an enhancer for p53 transcriptional, but later studies have demonstrated that it is actually a substrate for ataxia telangiectasia mutated (ATM). 53BP1 is a classic late DNA damage response...    Read more.
53BP1 - DNA damage is no fun
The 53BP1 (p53 binding protein 1) was initially believed to be a p53 transcriptional enhancing partner, but it has now been established as an ataxia telangiectasia mutated (ATM) substrate. As a late DNA damage response (DDR) marker, 53BP1 appears duri...    Read more.
53BP1, DNA Damage Response and Tumor Suppression
53BP1 (p53 binding protein 1) was originally thought to be a p53 transcriptional enhancing partner, but now has been shown to be an ataxia telangiectasia mutated (ATM) substrate. It is a late DNA damage response (DDR) marker, appearing in the telophas...    Read more.
53BP1, DNA Damage Response and Tumor Suppression
53BP1 (p53 binding protein 1) was originally thought to be a p53 transcriptional enhancing partner, but now has been shown to be an ataxia telangiectasia mutated (ATM) substrate. It is a late DNA damage response (DDR) marker, appearing in the telophas...    Read more.
NUP153 & 53BP1: A Novel DNA Repair Pathway
Mediating DNA damage is a crucial process, and one of the most important cellular guards against cancer. In response to DNA damage, sophisticated cellular machinery is recruited to repair the breaks, and if it fails, the cell is committed to death. De...    Read more.
Blocking 53BP1 Expression Lessens Tumor Development in BRCA1-Defective Mice
Our antibody database at Novus Biologicals provides research tools for the forefront of cancer research. Recently, a mouse study using 53BP1 and BRCA1 antibodies showed that deletion of 53BP1 greatly lessened the incidence of tumor development in mice...    Read more.
Read more 53BP1 related blogs.