ATRX Products

Description

ATRX is a member of the SNF2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif and is expressed as a 280 kDa protein. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 alpha to mediate chromosomal segregation. Mutations in the ATRX gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with alpha thalassaemia, or ATRX syndrome.

Bioinformatics

Entrez	546 Human
Uniprot	NP_000480.2 Human
Product By Gene ID	546
Alternate Names	alpha thalassemia/mental retardation syndrome X-linked (RAD54 (S. cerevisiae)homolog) alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S.cerevisiae) alpha thalassemia/mental retardation syndrome X-linked ATP-dependent helicase ATRX ATR2 DNA dependent ATPase and helicase EC 3.6.1 EC 3.6.4.12 helicase 2, X-linked Juberg-Marsidi syndrome MGC2094 MRXHF1 RAD54 homolog RAD54L SFM1 SHS transcriptional regulator ATRX XH2RAD54 X-linked helicase II X-linked nuclear protein XNPZNF-HX Zinc finger helicase Znf-HX

Research Areas for ATRX

Find related products by research area and learn more about each of the different research areas below.

Cancer
Checkpoint signaling
DNA Double Strand Break Repair
DNA Repair