Neuroscience research aims to understand the anatomy and function of the brain. Elucidating the intricate cellular networks controlling behavior often requires a multidisciplinary approach. Commonly, research in neuroscience integrates concepts and experimental approaches from physiology, biochemistry,
cellular and molecular biology, computational biology, and behavioral biology.
Historically, two major areas of neuroscience research: Molecular and Cellular neuroscience and Developmental neuroscience have relied on antibodies and peptides as essential tools for unraveling complex neuroscience principles, from the factors that specify neuronal identity to the workings at the synapse.
Developmental neuroscience- studies the formation of the nervous system, from cellular components to how these are organized in major functional networks
Molecular and Cellular neuroscience- focuses on the molecules and genes controlling brain cellular function
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Research findings in these major areas provide the foundation for understanding brain disease mechanisms and developing therapeutic approaches for a wide range of conditions including Neurodegenerative and Neuroinflammatory diseases. Neurodegenerative diseases, or conditions leading to the irreversible loss of nerves and concomitant loss of function, impact the health of millions of people around the globe. Among these, Alzheimer’s and Parkinson’s disease constitute the leading cause of dementia worldwide.
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A common theme among this diverse group of conditions is the presence of protein aggregates, indicative of protein homeostasis malfunction. Autophagy has emerged as a critical mechanism in neurodegenerative diseases for its central role in the clearance of cellular components via the autophagosome.
Read White Paper: Autophagy in Neurodegenerative Diseases: At the Intersection of Cellular Homeostasis and Disease
Learn about Neuroscience Cell Identity Markers