Mitogen Activated Protein Kinase (MAPK) signaling pathways are responsible for regulating a variety of cellular activities, including proliferation, differentiation and apoptosis, in response to certain environmental stimuli. Three major MAPK pathways have been identified in mammals: MAPK/ERK, SAPK/JNK and p38 MAPK.
The four p38 MAPK family members (p38), MAPK11, SAPK3 & SAPK4) are activated by external stress, inflammatory cytokines or UV radiation. Once activated, this pathway initiates production of the pro-apoptotic transcription factors PAX6, ELK1, CHOP, MEF2, ATF2, ETS1, MAX, p53, CREB, NFkB p65, ATF1 and ER81.
Find available products by clicking on key proteins in the p38 signaling interactive pathway below:
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