HIF-1 alpha Products

Antibodies
HIF-1 alpha Antibody
HIF-1 alpha Antibody
Species: Hu, Mu, Rt, Gt, Ha, Pm, Rb
Applications: WB, ChIP, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Host: Rabbit Polyclonal
HIF-1 alpha Antibody
HIF-1 alpha Antibody
Species: Hu, Mu, Rt, Ch, Mk, Bovine, Canine, Equine, Fish, Guinea Pig, Goat, Primate, Porcine, Rabbit, Zebrafish, Turkey, Rhesus Macaque
Applications: WB, ChIP, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, PLA
Host: Rabbit Polyclonal
Antibody Packs
HIF-1 alpha Antibody Pack
HIF-1 alpha Antibody Pack
Species: Hu, Mu, Rt, Pm
Applications: WB, ChIP, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Host: Mouse
HIF-1 alpha Antibody Pack
HIF-1 alpha Antibody Pack
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
HIF-1 alpha Antibody Pack
HIF-1 alpha Antibody Pack
Species: Hu, Mu
Applications: WB, ChIP, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Antibody Pairs
HIF-1 alpha Antibody Pair
HIF-1 alpha Antibody Pair
H00003091-PW1
Species: Hu
Applications: WB, IP
Kits
HIF-1 alpha Assay Kit
HIF-1 alpha Assay Kit
KA1321
Applications: Func
Lysates
HIF-1 alpha Overexpression Ly ...
HIF-1 alpha Overexpression Lysate ...
NBP2-04440
Species: Hu
Applications: WB
HIF-1 alpha Overexpression Ly ...
HIF-1 alpha Overexpression Lysate ...
H00003091-T01
Species: Hu
Applications: WB
Proteins
HIF-1 alpha Recombinant Prote ...
HIF-1 alpha Recombinant Protein
H00003091-P01
Species: Hu
Applications: WB, ELISA, PA
HIF-1 alpha Recombinant Prote ...
HIF-1 alpha Recombinant Protein
NBC1-18422
Species: Hu
Applications: PAGE
HIF-1 alpha Peptide
HIF-1 alpha Peptide
NBP1-47179PEP
Species: Hu
RNAi
HIF-1 alpha RNAi
HIF-1 alpha RNAi
H00003091-R02
Species: Hu
HIF-1 alpha RNAi
HIF-1 alpha RNAi
H00003091-R01
Species: Hu

Description

HIF-1 comprises of HIF-1 alpha and HIF-1 beta subunits which are frequently translated. The nuclear protein, HIF-1 alpha interacts with several protein factors. Under hypoxic conditions, HIF-1 alpha activates the transcription of over 40 genes and prevents HIF degradation due to the lack of hydroxylation. In normoxic conditions, HIF-1 alpha is degraded by the proteasome system. HIF-1 beta remains stable in either condition.

Bioinformatics

Entrez Human
Mouse
Rat
Bovine
Sheep
Uniprot Human
Human
Human
Human
Mouse
Rat
Product By Gene ID 3091
Alternate Names
  • HIF1A
  • HIF-1 alpha
  • ARNT-interacting protein
  • HIF1-alpha
  • HIF-1-alpha
  • BHLHE78
  • Member of PAS protein 1
  • member of PAS superfamily 1
  • Class E basic helix-loop-helix protein 78
  • hypoxia-inducible factor 1-alpha
  • Basic-helix-loop-helix-PAS protein MOP1
  • PASD8alpha subunit (basic helix-loop-helix transcriptionfactor)
  • MOP1HIF1-ALPHA
  • PAS domain-containing protein 8
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcriptionfactor)

Research Areas for HIF-1 alpha

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Autophagy
Cancer
Cellular Markers
Chromatin Research
HIF Target Genes
Hypoxia
mTOR Pathway
Transcription Factors and Regulators

Bioinformatics Tool for HIF-1 alpha

Discover related pathways, diseases and genes to HIF-1 alpha. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related HIF-1 alpha Blog Posts

Check out the latest blog posts on HIF-1 alpha.
The relationship between Ki67 and HIF-1 in cancer
Ki67, also known as MKI67, is best known as the leading marker of cellular proliferation. Ki67 is regulated by a balance between synthesis and degradation, and often carries a very short half-life.  First discovered to be located to dividing cells,...    Read more.
Controls for HIF-1 Alpha's WB, ICC-IF, IHC, IP & FLOW Analysis
Tips on positive and negative controls for HIF-1 alpha antibodies is one of the most Frequently Asked Questions on Hypoxia and HIFs. Here are top 5 suggestions from Novus Biologicals: The degradation of HIF1 alpha is the most common issue whic...    Read more.
Understanding the relationship between HIF-1 alpha, Hypoxia and Epithelial-Mesenchymal Transition
Epithelial-mesenchymal transition (EMT) is a natural process by which epithelial cells lose their polarity and intercellular adhesion, and gain the migratory invasive properties of mesenchymal stem cells that can differentiate into a variety of cel...    Read more.
HIF-2 alpha: HIF1A's Homologue with Similar and Divergent Functions
HIF-2 alpha is a member of the heterodimeric hypoxia-inducible factors/HIFs family (HIF-1, HIF-2, and HIF-3) which contains a common beta subunit but differ in their alpha subunits. Also called as EPAS1 or Mop2, HIF-2 alpha regulates cellular adapt...    Read more.
HIF-3 alpha: a versatile target with hypoxia dependent and independent functions
By: Subhash GangarHIF-3 alpha (hypoxia-inducible factor 3-alpha/ HIF3A) represents an isoform of HIF-alpha subunits which heterodimerize with stable beta subunit (HIF-beta) for the regulation of HIF target genes through binding to hypoxia respon...    Read more.
HIF-1 alpha - sensing and responding to changing oxygen levels
Hypoxia-inducible factor 1 (HIF-1) allows cells to respond to changing levels of oxygen in the environment. HIF-1 is a heterodimeric transcription factor consisting of alpha and beta subunits. Under normal conditions HIF-1 alpha is continuously sy...    Read more.
Comprehensive Autophagy Research Tools - New Catalog Available Now!
Autophagy, a protein degradation process through autophagosome-lysosomal pathway, is important for cellular homeostasis and plays a role in many diseases. To help researchers learn more about this process and the products available for its study, N...    Read more.
HIF-1 beta: A dimerization partner of HIF-1 alpha required for an adaptive response to hypoxia
Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. Hypoxia-indu...    Read more.
HIF-1 Alpha: Infographic
Encoded by the HIF1A gene, HIF-1 alpha has a critical role in cellular response to hypoxia. In hypoxic conditions, HIF-1 alpha activates the transcription of several genes to facilitate metabolic reaction for lack of oxygen. In normoxic conditions, HI...    Read more.
Controlling the HIF-1 Switch
Hypoxia-inducible factor-1 is a major transcription factor composed of two subunits: HIF-1alpha and HIF-1 beta. Under normoxic conditions, HIF-1 alpha is targeted to proteosomal degradation via ubiquitination. On the other hand during hypoxic conditio...    Read more.
Hypoxia Inducible Factor-1 beta and Cancer Development
Hypoxia inducible factor-1 (HIF-1) is a major transcription factor that is composed of two subunits: HIF-1 alpha and HIF-1 beta, the latter being a constitutively-expressed aryl hydrocarbon receptor nuclear transporter (ARNT). Under normoxic condition...    Read more.
HIF Prolyl Hydroxylase 2: an important Oxygen Sensor Protein
Prolyl hydroxylase domain (PHD) proteins, including PHD1, PHD2, and PHD3, mediate oxygen-dependent degradation of hypoxia-inducible factor (HIF) alpha subunits. Suppression of PHD enzymes leads to stabilization of HIFs and offers a potential treatment...    Read more.
Myc-tag: The "Monkey Wrench" of Proteomic Tools
c-Myc is a well-characterized transcription factor encoded by the c-Myc gene on human chromosome 8q24. This cellular proto-oncogene, also known as p62, is commonly activated in a variety of tumor cells and plays a crucial role in cellular proliferatio...    Read more.
MAT2a, MAT2b, HIF-1 alpha: Roles in Liver Cancer and DNA methylation
Methionine Adenosyltransferase II alpha, also known as MAT2a, is a catalytic subunit of methionine adenosyltransferase (MAT) and essential enzyme for the catalysis of the principle biological methyl donor, S-adenosylmethionine (SAM) from methionine an...    Read more.
Heat Shock Proteins: An Overview
Heat Shock Proteins (HSPs) are a ubiquitous group of molecular chaperone proteins that have evolved unique mechanisms, within their host cells, to facilitate survival in hostile environments such as heat, oxidative (hypoxia), pH and cold. Under permis...    Read more.
Carbonic Anhydrase IX and Hypoxic Response: A Path to Tumors
Carbonic Anhydrase IX (CA-IX) is an enzyme that is induced under hypoxic conditions. This enzyme is rarely present in normal cells and is responsible for controlling tumor pH. CA-IX is a transmembrane glycoprotein of the zinc metalloenzyme family. Thi...    Read more.
HIF-2 alpha Antibody Throws New Light on EPO Dilemma
The HIF family are heterodimeric, oxygen-sensitive transcription factors comprising an alpha and beta subunit which are normally dissociated in normoxic conditions. Our antibody catalog contains products targeting all the Hypoxia Inducible Factor isof...    Read more.
HIF Antibodies: Beyond HIF-1 alpha
The hypoxia inducible factors are a family of heterodimeric transcription factors which are activated in response to lowered oxygen levels, or hypoxia. Although it may seem that HIF-1 alpha receives all the attention, other HIF antibodies, such as the...    Read more.
A Role for HIF-1 alpha Antibody in Renal Research
The Hypoxia Inducible Factors (HIFs) are a family of mammalian transcription factors which are expressed in response to low cellular oxygen concentrations (hypoxia). Three human hypoxia inducible factors have been identified, HIF-1, HIF-2 and HIF-3, e...    Read more.
Hypoxia-Inducible Factors and Homeostasis
Hypoxia-Inducible Factor-1 (HIF-1) is a highly conserved heterodimeric transcription factor. Novus' antibody catalogue contains an extensive range of both HIF-1 alpha and HIF-1 beta, useful for hypoxia, angiogenesis, cancer and many other areas of res...    Read more.
We Heart HIF: HIF-1 Improves Angiogenesis Therapy in Ischemic Heart Tissue
Ischemic cardiovascular disease is the leading cause of death for both men and women in the US and most other industrialized countries. Most commonly caused by atherosclerosis of the coronary arteries, ischemic cardiovascular disease is characterized...    Read more.
Using the Hif-1 Alpha Antibody in Prostate Cancer Research
The Hypoxia-inducible Factor 1 (HIF1) protein is a heterodimeric transcription factor which plays an important role in mammalian oxygen homeostasis in conditions of hypoxia, or low oxygen concentration. HIF-1 alpha antibody reagents are widely used in...    Read more.
HIF-1 Beta Antibody Studies and Developments in Hypoxia Research
We at Novus Biologicals have a large HIF-1 (Hypoxia Inducible Factor-1) antibody catalog, with twenty HIF-1 beta antibody products specifically targeted to the beta subunit of HIF-1, a heterodimer which is known to contribute to many human diseases ar...    Read more.
The Role of LC3 within the Autophagic Pathway
We at Novus Biologicals have a broad antibody databasecovering the area of autophagy - over 1400 reagents in total. Autophagy is bulk degradation of cytoplasmic components - literally, self-digestion of the cell. Double-membrane vesicles, called autop...    Read more.
The Link Between Base Excision Repair and Cancer Antibodies
Base excision repair (BER) is the most fundamental DNA repair mechanism, dealing with alterations arising in individual DNA bases during cellular metabolism. We at Novus Biologicals have a large BER antibody database, which has proven important in var...    Read more.
Read more HIF-1 alpha related blogs.