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Cancer can simply be defined as an abnormal growth or proliferation of cells. The causes of cancer vary widely from environmental factors (smoking, obesity, radiation, infections, etc.) to acquired and inherited mutations. Most cancerous cells are derived from gene mutations and the prime suspects driving these diseases are oncogenes and tumor suppressor genes. There more than 100 described types of cancer and they are generally named for the organ in which they originate.
One field of research driving the study of cancer is oncogenomics, which is study of genes and mutations and how they contribute to the development, progression, and metastasis of cancer. Through high throughput screening and other technologies, scientists have been able to systematically identify genes which cause certain cancers, leading to new understandings into the origins and proliferation of certain diseases. These studies are helping in the discovery new targets for therapy, predicting clinical outcome, and better diagnoses for cancers.
Visit our cancer diseases page to view more detailed information about specific cancers and the products offered by Novus Biologicals.
At Novus Biologicals, we have a vast catalog of competitively priced antibodies for scientific research. Our IL-6 antibodies, Osteopontin antibodies, and p21 antibodies are widely used for applications such as immunoprecipitation and immunofluorescence.
Antibody targets such as TNF alpha, MMP2, BRCA, ErbB2, NOD2, Profilin and Ki67 are powerful tools in cancer research. We aim to be at the forefront of science, providing the latest monoclonal and polyclonal antibodies to researchers.
IL-6 antibodies, often known as IL-6, is a pluripotent cytokine which plays a role in the pathophysiology of severe infection and regulates the immune response, acute phase reaction and haematopoiesis. Our IL-6 monoclonal antibody is used for the study of advanced cancers. Clinically, the IL-6 antibody locates and binds to cancer cells, and is used to block inflammation and tumor growth.
Various Il-6 antibody preparations have been used in ELISA assays to detect and analyze human IL-6 and its interaction with other systems.
The monoclonal Ki67 antibody identifies the Ki67 antigen. Ki67 is routinely used as a marker for cellular proliferation, e.g. in tumor cells. It is detected by using the Ki67 antibody.
Ki67 is extensively found in active cells, but is absent from resting ones. Ki67 antibody preparations are used in immunohistochemistry to track the cell growing fraction of neoplastic tissues via ki67 levels.
The MMP2 gene is involved in the breakdown of the extracellular matrix. The MMP2 antibody detects MMP2 in both its proenzyme and active (cleaved) state. The active form of MMP2 is not found in benign tumors; therefore, detection of the enzyme is a possible early indicator of tumor activity.
The MMP2 antibody is useful in Western blot assays, however, it is mainly used with recombinant protein. The MMP2 antibody also works well on frozen and paraffin-embedded tissues.
Osteopontin is an organic component of bone, and is involved in many physiological processes. Osteopontin antibodies are used in cancer research because it is over-expressed in a number of important cancers.
Osteopontin antibodies are used as markers to track the development of cancer cells in vitro, and have also been used in kidney, asthma and MS research. Both full-length and fragmented Osteopontin are recognized by the Osteopontin antibody.
p21 antibodies are involved in mammalian cell cycle progression. Overproduction of p21 inhibits mammalian cell growth and can be effected by a wide range of stimuli.
p21 antibodies are used for p21 detection in a variety of applications, including: Western blot, immunoprecipitation and immunofluorescence.
Tumor Necrosis Factor alpha, commonly referred to as TNF-alpha, is closely involved with acute inflammatory response. TNF production has been implicated in a variety of diseases, including cancer; therefore, it is commonly used in this research.
By promoting the inflammatory response, TNF causes many of the medical problems associated with autoimmune diseases. TNF-alpha antibodies have been used in research for rheumatoid arthritis, Crohn's disease, psoriasis and advanced sepsis.
At Novus Biologicals, we have a substantial range of competitively priced antibodies for scientific research. We employ the tightest quality controls to ensure the best results for every application.