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KDM2A/FBXL11 (F-box and leucine-rich repeat protein 11) is a histone demethylase which has an important role in histone code as well as epigenetic silencing. KDM2A/FBXL11 is known to have interactions with SMAD7, SMAD3, ZNF512B, HIST2H3A and HIST2H3C. KDM2A/FBXL11 has been studied in relation to anemia and Fanconi's anemia.