White papers

Read and download our white papers below!

Autophagy in Neurodegenerative Diseases Autophagy in Neurodegenerative Diseases

Autophagy is the main pathway for the clearance of large protein aggregates present in Neurodegenerative Diseases. This review provides a comprehensive overview of molecular targets interconnecting the process of autophagy and neurodegeneration mechanisms.

engineered cell lines Engineered cell lines which stably express SEAP reporter proteins

Reporter cell lines provide a simple, rapid and reliable method of monitoring the activity of signalling pathways. This document introduces our engineered cell lines which stably express SEAP reporter proteins.

cellular response to hypoxia Cellular Response to Hypoxia

The cellular response to hypoxia has become of medical interest, as hypoxia causes broad physiological changes in the cell. Read Novus’ protocols and troubleshooting tips for working with hypoxia research reagents.

metastasis in cancer Metastasis In Cancer

Metastasis is the process by which cells within a tumour develop the ability to invade in to surrounding tissues to form new growths at distant parts of the body relative to the original tumour site. This paper provides an overview of the key protein classes and research areas that are of interest in metastasis research.

ligands and inhibitors Ligands and Inhibitors of TLR Reporter Cell Lines

TLRs are amongst the most comprehensively studied Pattern Recognition Receptors due to their central role in host defences and their involvement in a number of diverse pathological processes.

unfolded protein response Unfolded Protein Response

The UPR is a cellular stress response related to the Endoplasmic Reticulum, and is activated following an accumulation of unfolded or misfolded proteins in the ER lumen. This paper provides an overview of some of the key proteins that are known to be involved in the UPR.

neural therapy Neural Stem Cell Therapy

Neural Stem Cells are the progenitors to the specialised cells of the Central Nervous System and have been proposed as a promising therapy for the treatment of a wide variety of neuropathologies and brain/spinal cord injuries. This paper provides a summary of their use in a number of different conditions.

traumatic brain injury Traumatic Brain Injury

Traumatic Brain Injury (TBI) is defined as an injury to the brain caused by trauma to the head, and often leads to dysfunction of the blood brain barrier (BBB). This paper provides an introduction to the various proteins which can be used as biomarkers of BBB disruption.