HDAC5 Products

Description

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF(p300/CBP- associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-6, have been identified as histone deacetylases.

Bioinformatics

Entrez	10014 Human 15184 Mouse 84580 Rat
Uniprot	AAH51824 Human EAW51633 Human NM_005474 Human NP_001015053 Human Q9UQL6 Human
Product By Gene ID	10014
Alternate Names	Antigen NY-CO-9 EC 3.5.1.98 FLJ90614 HD5 histone deacetylase 5 KIAA0600 NY-CO-9

Research Areas for HDAC5

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Cell Cycle and Replication
Chromatin Research
Epigenetics
Histone Deacetylases
Phospho-Specific

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