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Epigenetic Modulators

Uncovering underlying epigenetic mechanisms controlling gene expression is facilitated by the use of modulators, inhibitors or activators of epigenetic enzymes. A variety of small molecule modulators selectively target DNA methyltransferases and histone modifying enzymes (HMT, HDM, HAT, HDAC). Chemical epigenetic modulators serve as useful probes to dissect the role of specific modifying enzymes in the process of transcriptional regulation.

Epigenetic Modulators Targeting Histone Modifying Proteins

A 485, Potent & selective p300/CBP inhibitor; orally bioavailable





A 485, Potent & selective p300/CBP inhibitor; orally bioavailable

RG108, Non-nucleoside DNA methyltransferase inhibitor



RG108, Non-nucleoside DNA methyltransferase inhibitor

(+)-JQ1, Potent & selective BET bromodomain inhibitor; cell permeable



(+)-JQ1, Potent & selective BET bromodomain inhibitor; cell permeable

UNC 0642, Potent & selective G9a and GLP inhibitor



UNC 0642, Potent & selective G9a and GLP inhibitor

Trichostatin A, Potent histone deacetylase inhibitor





Trichostatin A, Potent histone deacetylase inhibitor

GSK J4, Histone KDM inhibitor; cell permeable



GSK J4, Histone KDM inhibitor; cell permeable



Available at Tocris.com/epigenetics


Learn more about Epigenetic Machinery