KMT2A/MLL Products

Antibodies
KMT2A/MLL Antibody
KMT2A/MLL Antibody
NB600-248
Species: Hu, Mu, Bovine, Canine, Chicken, Equine, Primate, Rabbit, Rat, Turkey, Rhesus Macaque
Applications: WB, Flow, IHC, IHC-P
Host: Rabbit Polyclonal
KMT2A/MLL Antibody
KMT2A/MLL Antibody
NB600-256
Species: Hu, Equine, Guinea Pig, Primate, Mouse, Rat, Monkey
Applications: WB, ChIP, IP, PLA
Host: Rabbit Polyclonal
KMT2A/MLL Antibody (10F8D7)
KMT2A/MLL Antibody (10F8D7)
NBP1-51542
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
Host: Mouse Monoclonal
RNAi
KMT2A/MLL RNAi
KMT2A/MLL RNAi
H00004297-R01
Species: Hu

Description

The MLL gene encodes a DNA-binding protein that methylates histone H3 (see MIM 601128) lys4 (H3K4) and positively regulates expression of target genes, including multiple HOX genes (see MIM 142980). MLL is a frequent target for recurrent translocations in acute leukemias that may be characterized as acute myeloid leukemia (AML; MIM 601626), acute lymphoblastic leukemia (ALL), or mixed lineage (biphenotypic) leukemia (MLL). Leukemias with translocations involving MLL possess unique clinical and biologic characteristics and are often associated with poor prognosis. MLL rearrangements are found in more than 70% of infant leukemias, whether the immunophenotype is more consistent with ALL or AML6, but are less frequent in leukemias from older children. MLL translocations are also found in approximately 10% of AMLs in adults, as well as in therapy-related leukemias, most often characterized as AML, that develop in patients previously treated with topoisomerase II inhibitors for other malignancies. More than 50 different MLL fusion partners have been identified. Leukemogenic MLL translocations encode MLL fusion proteins that have lost H3K4 methyltransferase activity. A key feature of MLL fusion proteins is their ability to efficiently transform hematopoietic cells into leukemia stem cells (Krivtsov and Armstrong, 2007 (PubMed 17957188)).(supplied by OMIM)

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Product By Gene ID 4297
Alternate Names
  • EC 2.1.1.43
  • MLL1
  • CXXC-type zinc finger protein 7
  • HTRX
  • Zinc finger protein HRX
  • ALL1
  • Trithorax-like protein
  • MLL/GMPS fusion protein
  • Lysine N-methyltransferase 2A
  • MLL/GAS7 fusion protein
  • MLL1A
  • HTRX1MLL-AF4 der(11) fusion protein
  • TRX1histone-lysine N-methyltransferase MLL
  • KMT2ACDK6/MLL fusion protein
  • CXXC7TET1-MLL
  • ALL-1MLL/GAS7
  • HRXFLJ11783
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog)
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

Research Areas for KMT2A/MLL

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Transcription Factors and Regulators

Bioinformatics Tool for KMT2A/MLL

Discover related pathways, diseases and genes to KMT2A/MLL. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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