HIF-2 alpha/EPAS1 Antibody - BSA Free

WNT11 is induced by hypoxia or hypoxic mimetics in different cell types. Immunoblot analyses of HeLa cells under normal air or hypoxia for 24 hrs. Image collected and cropped by CiteAb from the following publication (//www.nature.com/articles/srep21520) licensed under a CC-BY license.

HIF-1alpha is the predominant transcriptional regulator of WNT11 expression during hypoxia. EMSCs isolated from the indicated mouse genotypes were infected with lentivirus expressing GFP or Cre recombinase. Non-infected cells and GFP infected cells served as controls. Immunoblot analyses of EMSCs derived from the indicated genotypes treated with 0.1 mM DMOG for 24 hrs. Attenuated WNT11 expression in Hif-1alpha KO EMSCs (lenti-Cre infected Hif-1af/f). Image collected and cropped by CiteAb from the following publication (//www.nature.com/articles/srep21520) licensed under a CC-BY license.

Formalin-fixed paraffin-embedded tissue sections of human placenta were probed for HIF-2 alpha/EPAS1 mRNA (ACD RNAScope Probe, catalog #410598; Fast Red chromogen, ACD catalog # 322750). Adjacent tissue section was processed for immunohistochemistry using Rabbit Polyclonal (Novus Biologicals catalog # NB100-122) at 1:100 dilution with one-hour incubation at room temperature followed by incubation with anti-rabbit IgG VisUCyte HRP Polymer Antibody (Catalog # VC003) and DAB chromogen (yellow-brown). Tissue was counterstained with hematoxylin (blue). Specific staining was localized to trophoblastic cells.

Expression of hypoxia-inducible alpha subunits in normal and diseased lung tissue. HIF-2alpha expression are more evident in fibroblasts from idiopathic pulmonary fibrosis (d) than from lung tissue affected by other inflammatory conditions (i.e. chronic bronchitis, panel e) or normal lung tissue (f); as demonstrated by a higher proportion of positive fibroblasts (open arrows) than negative ones (solid black arrows). Image collected and cropped by CiteAb from the following publication (//respiratory-research.biomedcentral.com/articles/10.1186/s12931-019-1100-4) licensed under a CC-BY license.

Image shows a specific band for HIF-2 alpha in 0.5 mg/mL of hypoxic HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.

Immunoblot validation of HIF2A and PHD2 KO clones using HIF2A (#NB100-122; dilution: 1/300), PHD2 (#NB100-137; dilution: 1/500). To blot HIFs factor cells were first pre-treated for 5 h with CoCl2 300 uM before protein extraction, a condition that promotes HIF factor accumulation. Image collected and cropped by CiteAb from the following publication (//www.nature.com/articles/s41467-018-06988-3) licensed under a CC-BY license.

HIF-2 alpha in human retinal and choroidal primary endothelia lysates using .. Image from verified customer review.

HIF-2 alpha in MDA-MB-231 cell lysate (overexpression and endogenous samples) using . did not react to HIF-1 alpha overexpression. Image from verified customer review.

Induced WNT11 expression with tumor hypoxia and WNT11 regulates tumor growth. Bevacizumab increased expression of HIF-1alpha and HIF-2alpha and WNT11. First 10 lanes are control tumors, and the last 10 lanes are tumors from bevacizumab-treated animals. Lysates from whole tissue and nuclei are indicated. Alpha -Tubulin, actin and lamin A/C are loading controls. Image collected and cropped by CiteAb from the following publication (//www.nature.com/articles/srep21520) licensed under a CC-BY license.

MDA-MB-231 cells were exposed to 20% or 1% O2 for 16 hours, and chromatin immunoprecipitation (ChIP) was performed with the indicated antibody (Ab). Primers flanking the HIF binding site were used for qPCR. ChIP image submitted by a verified customer review.

Lane 1: Cobalt chloride treated COS7 nuclear extracts. Lane 2: Untreated COS7 nuclear extracts.

786-O cells without or with VHL overexpression. Image from verified customer review.

Analysis using the HRP conjugate of NB100-122. Detection of normoxic and hypoxic nuclear rat cell lysates.

HIF-2 alpha immunoreactivity in human cardiac myocytes stained with NB100-122.

Expression and correlation of 3 antibodies: HIF-1 alpha, HIF-2 alpha and HAF in ccRCC. (A, C & E) Positive nuclear staining to the 3 antibodies: HIF-1 alpha, HIF-2 alpha and HAF, in primary ccRCCs at high magnification (100X). (B, D & F) Heterogenous nuclear staining of 3 antibodies in a tumor at low magnification (20X). (G, H and I). Correlation of 3 antibodies with the Fuhrman grade.Citation: Ambrosetti D, Dufies M, Dadone B, Durand M, Borchiellini D, Amiel J, et al. (2018) The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma. PLoS ONE 13(2): e0193477. //doi.org/10.1371/journal.pone.0193477

Reduction of HIF-2alpha levels leads to protection in UV-triggered apoptosis, but not for apoptosis caused by glucose and serum starvation in 786-O cells. Parental 786-O or those either stably expressing wild-type VHLp19 or stably infected with a control vector (pSuperRetro) or a pool of two HIF-2alpha shRNAs vectors [21] were grown to confluence and lysed. Cell alpha-tubulin.

• Reactivity: Hu, Mu, Rt, Fi, Ha, Pm, Rb, Re, Sh
• Applications: WB, Simple Western, ELISA, Flow, Func, GS, ICC/IF, IHC, IP, PAGE, WB, ChIP, Dual ISH-IHC, KD, KO
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

HIF-2 alpha/EPAS1 Antibody - BSA Free Summary

• Immunogen: This HIF-2 alpha/EPAS1 Antibody was developed against a peptide derived from the C-terminus of mouse/human HIF-2 alpha protein.
• Specificity: This HIF-2 alpha/EPAS1 Antibody is specific for HIF-2 alpha/EPAS, and does not cross-react with HIF-1 alpha.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: EPAS1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Chromatin Immunoprecipitation (ChIP) 1:10-1:500
  • Dual RNAscope ISH-IHC
  • ELISA 1:100 - 1:2000
  • Flow Cytometry
  • Gel Super Shift Assays reported in scientific literature (PMID 15184875)
  • Immunoblotting reported in scientific literature (PMID 28115701)
  • Immunocytochemistry/Immunofluorescence 1:100
  • Immunohistochemistry 1:100
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin 1:100
  • Immunoprecipitation 5 ug / 1 mg lysate
  • In vitro assay reported in scientific literature (PMID 24998849)
  • Knockdown Validated reported in scientific literature (PMID 31061092)
  • Knockout Validated reported in scientific literature (PMID 26861754)
  • SDS-Page
  • Simple Western 1:50
  • Western Blot 1 - 2 ug/mL
• Application Notes: In WB, this antibody recognizes a band at 118 kDa representing HIF-2 alpha.
  Simple Western reported by an internal validation. Separated by Size- Wes/Sally Sue/Peggy Sue, antibody dilution of 1:50. Apparent MW in kDa on Simple Western was 110kDa; matrix was 12-230 kDa.
• Theoretical MW: 96.5 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Control:

  COS-7 Nuclear Hypoxic Induced Cell Lysate
  Human Rectum Whole Tissue Lysate (Adult Whole Normal)
  NIH 3T3 CoCl2 treated/Untreated Cell Lysate
  L929 CoCl2 treated/Untreated Cell Lysate
  Raw 264.7 CoCl2 treated/Untreated Cell Lysate
  PC12 CoCl2 treated/Untreated Cell Lysate
  PC12 Hypoxic / Normoxic Cell Lysate
  Raw 264.7 Hypoxic / Normoxic Cell Lysate
  L929 Hypoxic / Normoxic Cell Lysate
  NIH 3T3 Hypoxic / Normoxic Cell Lysate

Reactivity Notes

Use in Mouse reported in scientific literature (PMID:33758176).

Packaging, Storage & Formulations

• Storage: Store at -20 °C.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for HIF-2 alpha/EPAS1 Antibody - BSA Free

• anti hif 2 alpha
• anti-HIF-2 alpha
• Basic-helix-loop-helix-PAS protein MOP2
• BHLHE73
• Class E basic helix-loop-helix protein 73
• ECYT4
• endothelial PAS domain protein 1
• endothelial PAS domain-containing protein 1
• EPAS1
• EPAS-1
• HIF 2A
• HIF-1-alpha-like factor
• HIF-1alpha-like factor
• HIF2 alpha
• HIF-2 alpha
• hif2a angiogenesis
• HIF2A
• HIF-2-alpha
• HIF2-alpha
• HLF
• hypoxia-inducible factor 2 alpha
• Hypoxia-inducible factor 2-alpha
• Member of PAS protein 2
• MOP2
• PAS domain-containing protein 2
• PASD2

Background

Hypoxia contributes to the pathophysiology of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease (1). In cancer, and particularly solid tumors, hypoxia plays a critical role in the regulation of genes involved in stem cell renewal, epithelial to mesenchymal transition (EMT), metastasis and angiogenesis. In the tumor microenvironment (TME), hypoxia influences the properties and function of stromal cells (e.g., fibroblasts, endothelial and immune cells) and is a strong determinant of tumor progression (2,3).

HIF-1 or hypoxia inducible factor 1, is a transcription factor commonly referred to as a "master regulator of the hypoxic response" for its central role in the regulation of cellular adaptations to hypoxia. Similarly, HIF-2 alpha plays a role in cellular responses to hypoxia, but whereas HIF-1 alpha is ubiquitously expressed, HIF-2 alpha is predominantly expressed in the vascular endothelium at embryonic stages and after birth in select cells and tissue types (e.g., fibroblasts, hepatocytes and myocytes at 96kDa) (4). Following a similar mechanism to HIF-1 alpha, HIF-2 alpha is stabilized under hypoxic conditions by the formation of a heterodimer with an ARNT/HIF-1 beta subunit. Stable HIF-2 alpha-ARNT/HIF-1 beta heterodimers engage p300/CBP in the nucleus for binding to hypoxic response elements (HREs), inducing transcription, and thus regulation of genes (e.g., EPO, VEGFA). HIF-1 predominantly transactivates genes involved in glycolytic control and pro- apoptotic genes (e.g., LDHA and BNIP3), and HIF-2 regulates the expression of genes involved in invasion and stemness (e.g., MMP2, and OCT4). Common gene targets for HIF-1 and HIF-2 include VEGFA and GLUT1 (5).

The HIF-2 alpha subunit is rapidly targeted and degraded by the ubiquitin proteasome system under normoxic conditions. This process is mediated by oxygen-sensing enzymes, prolyl hydroxylase domain enzymes (PHDs), which catalyze the hydroxylation of key proline residues (Pro-405 and Pro-531) within the oxygen-dependent degradation domain of HIF-2 alpha (5). Once hydroxylated, HIF-2 alpha binds the von Hippel-Lindau tumor suppressor protein (pVHL) for subsequent ubiquitination and proteasomal degradation (5,6).

References

1. Semenza, G. L., Agani, F., Feldser, D., Iyer, N., Kotch, L., Laughner, E., & Yu, A. (2000). Hypoxia, HIF-1, and the pathophysiology of common human diseases. Advances in Experimental Medicine and Biology.

2.Muz, B., de la Puente, P., Azab, F., & Azab, A. K. (2015). The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy. Hypoxia. https://doi.org/10.2147/hp.s93413

3. Huang, Y., Lin, D., & Taniguchi, C. M. (2017). Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe? Science China Life Sciences. https://doi.org/10.1007/s11427-017-9178-y

4. Hu, C.-J., Wang, L.-Y., Chodosh, L. A., Keith, B., & Simon, M. C. (2003). Differential Roles of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in Hypoxic Gene Regulation. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.23.24.9361-9374.2003

5. Koh, M. Y., & Powis, G. (2012). Passing the baton: The HIF switch. Trends in Biochemical Sciences. https://doi.org/10.1016/j.tibs.2012.06.004

6. Koyasu, S., Kobayashi, M., Goto, Y., Hiraoka, M., & Harada, H. (2018). Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge. Cancer Science. https://doi.org/10.1111/cas.13483

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for HIF-2 alpha/EPAS1 Antibody (NB100-122)(765)

Publications using NB100-122	Applications	Species
Liao Q, Zhu C, Sun X et al. Disruption of sirtuin 7 in zebrafish facilitates hypoxia tolerance Journal of Biological Chemistry 2023-08-01 [PMID: 37481210] (In Vivo, B/N)	In Vivo, B/N
Kubaichuk K, Kietzmann T USP10 Contributes to Colon Carcinogenesis via mTOR/S6K Mediated HIF-1? but Not HIF-2? Protein Synthesis Cells 2023-06-08 [PMID: 37371055] (WB, Human, Mouse)	WB	Human, Mouse
Yue Y, Tang Y, Huang H et al. VBP1 negatively regulates CHIP and selectively inhibits the activity of hypoxia-inducible factor (HIF)-1? but not HIF-2? The Journal of biological chemistry 2023-05-16 [PMID: 37201586] (WB, Zebrafish)	WB	Zebrafish
Aboouf MA, Armbruster J, Guscetti F et al. Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice Scientific reports 2023-05-09 [PMID: 37161046] (IHC-P, Mouse)	IHC-P	Mouse
Qu M, Long Y, Wang Y et al. Hypoxia Increases ATX Expression by Histone Crotonylation in a HIF-2?-Dependent Manner International Journal of Molecular Sciences 2023-04-11 [PMID: 37108194] (B/N)	B/N
Leu T, Denda J, Wrobeln A, Fandrey J Hypoxia-Inducible Factor-2alpha Affects the MEK/ERK Signaling Pathway via Primary Cilia in Connection with the Intraflagellar Transport Protein 88 Homolog Molecular and cellular biology 2023-04-19 [PMID: 37074220]
Li KQ, Liu GJ, Liu XY et al. EPAS1 prevents telomeric damage-induced senescence by enhancing transcription of TRF1, TRF2, and RAD50 Zoological Research 2023-05-18 [PMID: 37070589] (WB, ICC/IF)	WB, ICC/IF
Sun H, Pratt RE, Dzau VJ, Hodgkinson CP Neonatal and adult cardiac fibroblasts exhibit inherent differences in cardiac regenerative capacity The Journal of biological chemistry 2023-04-10 [PMID: 37044217] (WB, ICC/IF, Mouse)	WB, ICC/IF	Mouse
Mayro B, Hoj JP, Cerda-Smith CG et al. ABL kinases regulate the stabilization of HIF-1? and MYC through CPSF1 Proceedings of the National Academy of Sciences of the United States of America 2023-04-18 [PMID: 37040401]
Ye J, Chen J, Li Y et al. Hepatocyte-specific knockout of HIF-2? cannot alleviate carbon tetrachloride-induced liver fibrosis in mice PeerJ 2023-04-03 [PMID: 37033734] (IHC-P, Mouse)	IHC-P	Mouse
Deval G, Nedder M, Degrelle S et al. Benzo(a)pyrene and Cerium Dioxide Nanoparticles in Co-Exposure Impair Human Trophoblast Cell Stress Signaling International journal of molecular sciences 2023-03-12 [PMID: 36982514] (IHC-P, Human) Details: Dilution: 1:500	IHC-P	Human
Sabharwal S, Dudley VJ, Landwerlin C, Schumacker P H2O2 transit through the mitochondrial intermembrane space promotes tumor cell growth in vitro and in vivo The Journal of biological chemistry 2023-03-17 [PMID: 36935009] (WB, Human)	WB	Human
Sangam S, Sun X, Schwantes-An TH et al. SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics American journal of respiratory and critical care medicine 2023-03-13 [PMID: 36913491]
Colson A, Depoix CL, Lambert I et al. Specific HIF-2? (Hypoxia-Inducible Factor-2) Inhibitor PT2385 Mitigates Placental Dysfunction In Vitro and in a Rat Model of Preeclampsia (RUPP) Hypertension (Dallas, Tex. : 1979) 2023-05-01 [PMID: 36876500] (WB, Human)	WB	Human
Zuo Q, Yang Y, Lyu Y et al. Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis Cell reports 2023-02-28 [PMID: 36857181] (WB, Mouse)	WB	Mouse
Kostyunina DS, Rowan SC, Pakhomov NV et al. Shear Stress Markedly Alters the Proteomic Response to Hypoxia in Human Pulmonary Endothelial Cells American journal of respiratory cell and molecular biology 2023-02-02 [PMID: 36730645] (WB)	WB
Quan Y, Dai J, Zhou S et al. HIF2?-induced upregulation of RNASET2 promotes triglyceride synthesis and enhances cell migration in clear cell renal cell carcinoma FEBS open bio 2023-02-02 [PMID: 36728187] (ChIP, WB, Human)	ChIP, WB	Human
Hashimoto Y, Tsuzuki-Nakao T, Kida N et al. Inflammatory Cytokine-Induced HIF-1 Activation Promotes Epithelial-Mesenchymal Transition in Endometrial Epithelial Cells Biomedicines 2023-01-14 [PMID: 36672719] (WB, B/N)	WB, B/N
Kong Y, Liu PK, Li Y et al. HIF2? activation and mitochondrial deficit due to iron chelation cause retinal atrophy EMBO molecular medicine 2023-02-08 [PMID: 36645044] (WB)	WB
Chen Z, Bordieanu B, Kesavan R et al. Lactate metabolism is essential in early-onset mitochondrial myopathy Science Advances 2023-01-06 [PMID: 36598990] (In Vivo)	In Vivo
Al-Gharaibeh N, Shively S, Vortmeyer A Characterization of Microscopic Multicellular Foci in Grossly Normal Renal Parenchyma of Von Hippel-Lindau Kidney Medicina 2022-11-24 [PMID: 36556926] (IHC-P, Human) Details: Dilution used 1:50	IHC-P	Human
DAtilo MN, Formigari GP, de Faria JBL, de Faria JML AMP kinase activation by Omega-3 polyunsaturated fatty acid protects the retina against ischemic insult: An in vitro and in vivo study Experimental eye research 2022-12-09 [PMID: 36509164] (ICC/IF, Human)	ICC/IF	Human
Yang Y, Chen C, Zuo Q Et al. NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification Sci Adv 2022-12-09 [PMID: 36490339] (WB, Chemotaxis, Human) Details: Citation using the DyLight 405 version of this antibody.	WB, Chemotaxis	Human
Ji X, Li G, Liu J et al. Chronic hypoxia leads to cognitive impairment by promoting HIF-2a-mediated ceramide catabolism and alpha-synuclein hyperphosphorylation Research Square 2022-11-01 [PMID: 36450714] (WB, Mouse)	WB	Mouse
Li G, Liu J, Guo M et al. Chronic hypoxia leads to cognitive impairment by promoting HIF-2 alpha -mediated alpha-synuclein hyperphosphorylation Research Square 2022-03-25 [PMID: 36450714] (WB, Mouse)	WB	Mouse
Nahoui-Zarouri I, L�ger C, El Samra G et al. Time-dependent effects of hypoxia on cell metabolism, signaling, and iron homeostasis in the hematopoietic progenitor model KG1a FEBS Open Bio 2023-07-01 [PMID: 36416440] (Func)	Func
Chen Y, Cattoglio C, Dailey GM et al. Mechanisms governing target search and binding dynamics of hypoxia-inducible factors eLife 2022-11-02 [PMID: 36322456] (Chip Cytometry, Human)	Chip Cytometry	Human
Aboouf MA, Armbruster J, Thiersch M et al. Pro-Apoptotic and Anti-Invasive Properties Underscore the Tumor-Suppressing Impact of Myoglobin on a Subset of Human Breast Cancer Cells International Journal of Molecular Sciences 2022-09-29 [PMID: 36232784] (ICC/IF)	ICC/IF
Ross BX, Jia L, Kong D et al. Hypoxia-Inducible Factor-1a in Rods Is Neuroprotective Following Retinal Detachment Investigative ophthalmology & visual science 2022-10-03 [PMID: 36223101] (WB, Mouse)	WB	Mouse
Ma Q, Beal JR, Song X et al. Extracellular Vesicles Secreted by Mouse Decidual Cells Carry Critical Information for the Establishment of Pregnancy Endocrinology 2022-10-11 [PMID: 36219207] (WB)	WB
Dowdell AS, Cartwright IM, Kitzenberg DA et al. Essential role for epithelial HIF-mediated xenophagy in control of Salmonella infection and dissemination Cell Reports 2022-09-27 [PMID: 36170839] (In Vivo)	In Vivo
Tiwari R, Bommi PV, Gao P et al. Chemical inhibition of oxygen-sensing prolyl hydroxylases impairs angiogenic competence of human vascular endothelium through metabolic reprogramming iScience 2022-10-21 [PMID: 36157579] (Func)	Func
Melanson G, Du Bois AC, Webster C, Uniacke J ISGylation directly modifies hypoxia-inducible factor-2 alpha and enhances its polysome association FEBS letters 2022-08-24 [PMID: 36053046]
Ye C, Li H, Li Y et al. Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE iScience 2022-09-16 [PMID: 36034219] (KD, WB, Human)	KD, WB	Human
Zhang B, Chen Y, Bao L, Luo W GPT2 Is Induced by Hypoxia-Inducible Factor (HIF)-2 and Promotes Glioblastoma Growth Cells 2022-08-20 [PMID: 36010673] (KO, WB, Human)	KO, WB	Human
Yan M, Komatsu N, Muro R et al. ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts Nature immunology 2022-08-23 [PMID: 35999392] (IHC-Fr, Mouse, Human)	IHC-Fr	Mouse, Human
Henning Y, Blind US, Larafa S et al. Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction Cell death & disease 2022-07-29 [PMID: 35906211] (WB, Human)	WB	Human
Ji L, Su S, Xin M et al. Luteolin ameliorates hypoxia-induced pulmonary hypertension via regulating HIF-2 alpha-Arg-NO axis and PI3K-AKT-eNOS-NO signaling pathway Phytomedicine : international journal of phytotherapy and phytopharmacology 2022-07-08 [PMID: 35843187] (IHC-P, Rat)	IHC-P	Rat
Tapio J, Halmetoja R, Dimova E et al. Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism Journal of Biological Chemistry 2022-07-01 [PMID: 35787374] (WB, Mouse)	WB	Mouse
Li S, Li W, Yuan J et al. Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome Nature metabolism 2022-06-01 [PMID: 35760869] (WB, Human)	WB	Human
Han JS, Jeon YG, Oh M et al. Adipocyte HIF2 alpha functions as a thermostat via PKA C alpha regulation in beige adipocytes Nature communications 2022-06-07 [PMID: 35672324] (IF/IHC, Mouse)	IF/IHC	Mouse
Salman S, Meyers DJ, Wicks EE Et al. HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy J Clin Invest 2022-05-02 [PMID: 35499076] (Chemotaxis, WB, Mouse, Human) Details: Citation using the Alexa Fluor 488 version of this antibody.	Chemotaxis, WB	Mouse, Human
Xia QS, Wu F, Wu WB et al. Berberine reduces hepatic ceramide levels to improve insulin resistance in HFD-fed mice by inhibiting HIF-2 alpha Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022-04-13 [PMID: 35429745] (WB, ICC/IF, IHC-P, Human, Mouse)	WB, ICC/IF, IHC-P	Human, Mouse
Moyama C, Fujita M, Ando S et al. Stat5b inhibition blocks proliferation and tumorigenicity of glioblastoma stem cells derived from a de novo murine brain cancer model American journal of cancer research 2022-03-15 [PMID: 35411230] (WB)	WB
Wolf C, Smith S, van Wijk SJL Zafirlukast Induces VHL- and HIF-2alpha-Dependent Oxidative Cell Death in 786-O Clear Cell Renal Carcinoma Cells International journal of molecular sciences 2022-03-25 [PMID: 35408930] (WB)	WB
Matho C VHL-P138R and VHL-L163R Novel Variants: Mechanisms of VHL Pathogenicity Involving HIF-Dependent and HIF- Independent Actions Front. Endocrinol. 13: 854365. doi: 10.3389/fendo 2022-01-01 [PMID: 35388293] (WB, Human)	WB	Human
Nelson LJ, Castro KE, Xu B et al. Synthetic lethality of cyclin-dependent kinase inhibitor Dinaciclib with VHL-deficiency allows for selective targeting of clear cell renal cell carcinoma Cell cycle (Georgetown, Tex.) 2022-03-04 [PMID: 35240916] (WB, Human)	WB	Human
Armstrong N, Storey CM, Noll SE et al. SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas Cell reports 2022-03-01 [PMID: 35235785] (Mouse)		Mouse
Qin y, Zhang J, Babapoor-Farrokhran S et al. PAI-1 is a vascular cell-specific HIF-2-dependent angiogenic factor that promotes retinal neovascularization in diabetic patients Science advances 2022-03-04 [PMID: 35235351] (IHC-Fr, Human)	IHC-Fr	Human
Zhao L, Han Q, Zhou L et al. Addition of glomerular lesion severity improves the value of anemia status for the prediction of renal outcomes in Chinese patients with type 2 diabetes Renal failure 2022-12-01 [PMID: 35188068] (IF/IHC, Human)	IF/IHC	Human
Wang X, Hu J, Fang Y et al. Multi-Omics Profiling to Assess Signaling Changes upon VHL Restoration and Identify Putative VHL Substrates in Clear Cell Renal Cell Carcinoma Cell Lines Cells 2022-01-29 [PMID: 35159281] (WB, Human)	WB	Human
Medeiros PJ, Pascetta SA, Kirsh SM et al. Expression of hypoxia inducible factor-dependent Neuropeptide Y Receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation The Journal of biological chemistry 2022-01-27 [PMID: 35093384] (WB, Human)	WB	Human
Mennerich D, Kubaichuk K, Raza GS et al. ER-stress promotes VHL-independent degradation of hypoxia-inducible factors via FBXW1A/ beta TrCP Redox biology 2022-01-18 [PMID: 35074541] (WB, Human, Mouse)	WB	Human, Mouse
Yang Y, Lu H, Chen C et al. HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia Nature communications 2022-01-14 [PMID: 35031618] (Chemotaxis, WB)	Chemotaxis, WB
Sabui S, Ramamoorthy K, Romero J et al. Hypoxia inhibits colonic uptake of the microbiota-generated forms of vitamin B1 via HIF-1 alpha-mediated transcriptional regulation of their transporters Journal of Biological Chemistry 2022-01-01 [PMID: 34998824]
Elamaa H, Kaakinen M, NAtynki M et al. PHD2 deletion in endothelial or arterial smooth muscle cells reveals vascular cell type-specific responses in pulmonary hypertension and fibrosis Angiogenesis 2022-01-08 [PMID: 34997404] (WB, Mouse)	WB	Mouse
Sun H, Li Q, Song Z, Li C Hypoxia induction of SH2D3A triggers malignant progression of lung cancer Stem cell research 2022-01-01 [PMID: 34929442] (Chemotaxis)	Chemotaxis
Garc�a Garc�a CJ, Acevedo Diaz AC, Kumari N et al. HIF2 Regulates Intestinal Wnt5a Expression Frontiers in Oncology 2021-11-25 [PMID: 34900719]
Shih HM, Pan SY, Wu CJ Et al. Transforming growth factor- beta 1 decreases erythropoietin production through repressing hypoxia-inducible factor 2 alpha in erythropoietin-producing cells Journal of biomedical science 2021-11-02 [PMID: 34724959] (Chemotaxis, Mouse)	Chemotaxis	Mouse
Kim HS, Kang YH, Lee J Et al. Biphasic Regulation of Mitogen-Activated Protein Kinase Phosphatase 3 in Hypoxic Colon Cancer Cells Molecules and cells 2021-10-31 [PMID: 34711689] (WB, Human)	WB	Human
Zhao S, Zhou L, Dicker DT Et al. Anti-cancer efficacy including Rb-deficient tumors and VHL-independent HIF1 alpha proteasomal destabilization by dual targeting of CDK1 or CDK4/6 and HSP90 Scientific reports 2021-10-22 [PMID: 34686682]
Lim S, Kim YJ, Park S Et al. mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent MUller glia eLife 2021-10-22 [PMID: 34677125] (WB, Mouse)	WB	Mouse
Sasagawa T, Nagamatsu T, Yanagisawa M Et al. Hypoxia-inducible factor-1 beta is essential for upregulation of the hypoxia-induced FLT1 gene in placental trophoblasts Molecular human reproduction 2021-10-19 [PMID: 34665260] (WB, Human)	WB	Human
D'Amico AG, Maugeri G, RasA DM Et al. Modulatory role of PACAP and VIP on HIFs expression in lung adenocarcinoma Peptides 2021-10-07 [PMID: 34627957] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Wakefield ZR, Tanaka M, Pampo C et al. Normal tissue and tumor microenvironment adaptations to aerobic exercise enhance doxorubicin anti-tumor efficacy and ameliorate its cardiotoxicity in retired breeder mice Oncotarget 2021-08-31 [PMID: 34504647]
Sun D, Lu F, Sheldon A et al. Neuronal deficiency of hypoxia-inducible factor 2? increases hypoxic-ischemic brain injury in neonatal mice Journal of Neuroscience Research 2021-11-01 [PMID: 34487578]
Li X, Zhang X, Xia J Et al. Macrophage HIF-2 alpha suppresses NLRP3 inflammasome activation and alleviates insulin resistance Cell reports 2021-08-24 [PMID: 34433035] (ICC/IF, Chemotaxis, IP)	ICC/IF, Chemotaxis, IP
Caielli S, Cardenas J, de Jesus AA Et al. Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE Cell 2021-08-19 [PMID: 34384544] (WB, Human)	WB	Human
Firmino NS, Cederberg RA, Lee CM Et al. Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer Oncoimmunology 2021-08-04 [PMID: 34377597] (FLOW, Mouse)	FLOW	Mouse
Arnaiz E, Miar A, Bridges E et al. Differential Effects of HIF2 alpha Antagonist and HIF2 alpha Silencing in Renal Cancer and Sensitivity to Repurposed Drugs Research Square 2021-02-25 [PMID: 34353313] (WB)	WB
Wang J, Liu R, Wang Y Et Al. Repression of the miR-627-5p by histone deacetylase 3 contributes to hypoxia-induced hepatocellular carcinoma progression J Cancer 2021-08-02 [PMID: 34335948] (Chemotaxis)	Chemotaxis
DeBerge M, Lantz C, Dehn S Et al. Hypoxia-inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair The Journal of experimental medicine 2021-09-06 [PMID: 34325467] (IF/IHC)	IF/IHC
Bertorello J, Sesen J, Gilhodes J et al. Translation reprogramming by eIF3 linked to glioblastoma resistance NAR Cancer 2021-07-28 [PMID: 34316689]
Zhang Z, Funcke JB, Zi Z et al. Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity Cell metabolism 2021-06-18 [PMID: 34174197]
Uba T, Matsuo Y, Sumi C et al. Polysulfide inhibits hypoxia-elicited hypoxia-inducible factor activation in a mitochondria-dependent manner Mitochondrion 2021-06-13 [PMID: 34133955]
Mehibel M, Xu Y, Li CG et al. Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models The Journal of clinical investigation 2021-06-01 [PMID: 34060485] (WB, Human)	WB	Human
Zheng S, Ni J, Li Y et al. 2-Methoxyestradiol synergizes with Erlotinib to suppress hepatocellular carcinoma by disrupting the PLAGL2-EGFR-HIF-1/2 alpha signaling loop Pharmacological research 2021-05-20 [PMID: 34022398]
Wang R, Godet I, Yang Y, et al. Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis Proc Natl Acad Sci 2021-05-11 [PMID: 33952697] (WB, Chemotaxis)	WB, Chemotaxis
Geng G, Liu J, Xu C et al. Receptor-mediated mitophagy regulates EPO production and protects against renal anemia eLife 2021-05-04 [PMID: 33942716] (WB, Mouse)	WB	Mouse
Hesse J, Groterath W, Owenier C et al. Normoxic induction of HIF-1 alpha by adenosine-A2B R signaling in epicardial stromal cells formed after myocardial infarction FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021-05-01 [PMID: 33913581] (WB, Rat)	WB	Rat
Skwarska A, Calder EDD, Sneddon D et al. Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor Cell chemical biology 2021-04-22 [PMID: 33910023] (WB, Human)	WB	Human
Lee SY, Park KH, Lee G et al. Hypoxia-inducible factor-2 alpha mediates senescence-associated intrinsic mechanisms of age-related bone loss Experimental & molecular medicine 2021-04-02 [PMID: 33811248] (IF/IHC, WB, Mouse)	IF/IHC, WB	Mouse
Ju C, Wang M, Tak E et al. Hypoxia-inducible factor-1 alpha -dependent induction of miR122 enhances hepatic ischemia tolerance The Journal of clinical investigation 2021-04-01 [PMID: 33792566] (WB, Human)	WB	Human
Xie H, Song J, Godfrey J et al. Glycogen metabolism is dispensable for tumour progression in clear cell renal cell carcinoma Nature metabolism 2021-03-01 [PMID: 33758423]
Li P, Liu Y, Qin X et al. SIRT1 attenuates renal fibrosis by repressing HIF-2 alpha Cell death discovery 2021-03-23 [PMID: 33758176] (WB, Mouse)	WB	Mouse
Sadaghianloo N, Contenti J, Declemy S et al. Hypoxia and hypoxia-inducible factors promote the development of neointimal hyperplasia in arteriovenous fistula The Journal of Physiology 2021-04-01 [PMID: 33608879] (WB)	WB
Tanimura A, Nakazato A, Tanaka N MYD88 signals induce tumour-initiating cell generation through the NF-kappa B-HIF-1 alpha activation cascade Scientific reports 2021-02-17 [PMID: 33597599] (WB, Mouse)	WB	Mouse
Chen K, Zeng J, Sun Y et al. Junction plakoglobin regulates and destabilizes HIF2alpha to inhibit tumorigenesis of renal cell carcinoma Cancer communications (London, England) 2021-02-16 [PMID: 33591636] (WB, Human)	WB	Human
Marinaccio C, Suraneni P, Celik H et al. LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms Cancer Discovery 2021-06-01 [PMID: 33579786] (WB, B/N)	WB, B/N
Dufies M, Verbiest A, Cooley LS et al. Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma Communications biology 2021-02-05 [PMID: 33547392] (Chemotaxis, WB, Human)	Chemotaxis, WB	Human
Shao M, Hepler C, Zhang Q et al. Pathologic HIF1 alpha signaling drives adipose progenitor dysfunction in obesity Cell stem cell 2021-01-27 [PMID: 33539723]
Ghosh M, Zhang D, Ollivierre H et al. Therapeutic inhibition of HIF2 alpha reverses polycythemia and pulmonary hypertension in murine models of two human diseases Blood 2020-12-17 [PMID: 33512384]
Wu JW, Hu H, Li D, Ma LK. Hypoxia-inducible factor 2-alpha-dependent induction of IL-6 protects the heart from ischemia/reperfusion injury Aging (Albany NY) 2021-02-15 [PMID: 33428604] (IP)	IP
Kida N, Matsuo Y, Hashimoto Y, et al. Cigarette Smoke Extract Activates Hypoxia-Inducible Factors in a Reactive Oxygen Species-Dependent Manner in Stroma Cells from Human Endometrium Antioxidants (Basel, Switzerland) 2021-01-03 [PMID: 33401600] (WB, Human)	WB	Human
Zhang S, Cao M, Hou Z et al. Angiotensin-converting enzyme inhibitors have adverse effects in anti-angiogenesis therapy for hepatocellular carcinoma Cancer Letters 2021-03-01 [PMID: 33383154]
Ibuki M, Lee D, Shinojima A et al. Rice Bran and Vitamin B6 Suppress Pathological Neovascularization in a Murine Model of Age-Related Macular Degeneration as Novel HIF Inhibitors International Journal of Molecular Sciences 2020-11-25 [PMID: 33255657]
Kerber, E L, Padberg, C Et al. The Importance of Hypoxia-Inducible Factors (HIF-1 and HIF-2) for the Pathophysiology of Inflammatory Bowel Disease. Int J Mol Sci 2020-11-13 [PMID: 33202783] (SW, Golden Syrian Hamster)	SW	Golden Syrian Hamster
Gkotinakou IM, Kechagia E, Pazaitou-Panayiotou K et al. Calcitriol Suppresses HIF-1 and HIF-2 Transcriptional Activity by Reducing HIF-1/2alpha Protein Levels via a VDR-Independent Mechanism Sci Rep 2020-11-06 [PMID: 33182300] (WB, Human, Mouse)	WB	Human, Mouse
Han Q, Han F, Fan Y et al. Notch3 is involved in the proliferation of renal cancer cells via regulation of cell cycle progression and HIF 2 alpha Oncol Lett 2020-10-22 [PMID: 33154777]
Kleszka K, Leu T, Quinting T et al. Hypoxia-inducible factor-2 alpha is crucial for proper brain development Scientific reports 2020-11-05 [PMID: 33154420] (IF/IHC, Mouse)	IF/IHC	Mouse
Romero Y, Castillejos-LOpez M, Romero-GarcIa S et al. Antitumor Therapy under Hypoxic Microenvironment by the Combination of 2-Methoxyestradiol and Sodium Dichloroacetate on Human Non-Small-Cell Lung Cancer Oxidative Medicine and Cellular Longevity 2020-10-12 [PMID: 33149807] (ICC/IF)	ICC/IF
Kim H, Cho Y, Kim HS et al. A system-level approach identifies HIF-2 alpha as a critical regulator of chondrosarcoma progression Nat Commun 2020-10-06 [PMID: 33024108] (WB, IF/IHC, Human)	WB, IF/IHC	Human
Lee D, Miwa Y, Wu J et al. A Fairy Chemical Suppresses Retinal Angiogenesis as a HIF Inhibitor Biomolecules 2020-10-04 [PMID: 33020402] (WB, B/N)	WB, B/N
Li Y, Dewar A, Kim YS et al. Pregnancy success in mice requires appropriate cannabinoid receptor signaling for primary decidua formation eLife 2020-09-29 [PMID: 32990600]
Zhou Y, Ming J, Deng M et al. Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-kappa B/HIF-2 alpha axis J. Mol. Med. 2020-08-28 [PMID: 32860098]
Samanta D, Huang T, Shah R et al. BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy Cell Rep [PMID: 32846130] (Chemotaxis, WB, Mouse) Details: Citation using the PE format of this antibody.	Chemotaxis, WB	Mouse
Tiwari A, Tashiro K, Dixit A Et Al. Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis Gastroenterology 2020-08-03 [PMID: 32768595] (Mouse)		Mouse
Wang YJ, Yang B, Lai Q et al. Reprogramming of m6A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia RNA Biol 2020-08-18 [PMID: 32746693]
Dowdell AS, Cartwright IM, Goldberg MS et al. The HIF target ATG9A is Essential for Epithelial Barrier Function and Tight Junction Biogenesis Mol. Biol. Cell 2020-07-29 [PMID: 32726170] (IP)	IP
Hoppe, G, Bolok, Y Et al. Rank Order of Small Molecule Induced Hypoxiamimesis to Prevent Retinopathy of Prematurity. Front Cell Dev Biol 2020-07-14 [PMID: 32656210] (IF/IHC, Human)	IF/IHC	Human
Kogure A, Naito Y, Yamamoto Y et al. Cancer cells with high-metastatic potential promote a glycolytic shift in activated fibroblasts PLoS ONE 2020-06-17 [PMID: 32555715] (WB, Human)	WB	Human
Riopel M, Moon JS, Bandyopadhyay GK et al. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2alpha-dependent mechanism Mol Metab 2020-06-11 [PMID: 32534258] (WB, Mouse)	WB	Mouse
Wu Y, Cao Y, Liu H et al. Remodelin, an inhibitor of NAT10, could suppress hypoxia-induced or constitutional expression of HIFs in cells Mol. Cell. Biochem. 2020-06-11 [PMID: 32529496]
Cohrs G, Drucks B, Synowitz M et al. Expression patterns of hypoxia inducible factors, pro-inflammatory, and neuroprotective cytokines in neuroepithelial tissues of lumbar spinal lipomas - a pilot study World Neurosurg 2020-06-06 [PMID: 32522652] (IF/IHC, Human)	IF/IHC	Human
van Gisbergen M, Offermans K, Voets A et al. Mitochondrial Dysfunction Inhibits Hypoxia-Induced HIF-1 alpha Stabilization and Expression of Its Downstream Targets Front. Oncol. 2020-05-19 [PMID: 32509579] (WB, Human)	WB	Human
Ho JJD, Balukoff NC, Theodoridis PR et al. A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism Nat Commun 2020-05-29 [PMID: 32472050] (WB, ICC, Human) Details: Citation using the HRP format of this antibody.	WB, ICC	Human
Lu H, Xie Y, Tran L et al. Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness J Clin Invest. 2020-05-19 [PMID: 32427586] (Chemotaxis, Human)	Chemotaxis	Human
Tiana M, Acosta-Iborra B, Hern�ndez R et al. Metabolic labeling of RNA uncovers the contribution of transcription and decay rates on hypoxia-induced changes in RNA levels RNA 2020-08-01 [PMID: 32295863] (WB, B/N)	WB, B/N
Park KT, Han JK, Kim SJ, Lim YH Gamma-Aminobutyric Acid Increases Erythropoietin by Activation of Citrate Cycle and Stimulation of Hypoxia-Inducible Factors Expression in Rats Biomolecules 2020-04-12 [PMID: 32290638] (IF/IHC, Rat)	IF/IHC	Rat
Shoda C, Miwa Y, Nimura K et al. Hypoxia-Inducible Factor Inhibitors Derived from Marine Products Suppress a Murine Model of Neovascular Retinopathy Nutrients 2020-04-10 [PMID: 32290307] (WB, Human, Mouse)	WB	Human, Mouse
Acosta-Iborra B, Tiana M, Maeso-Alonso L et al. Hypoxia compensates cell cycle arrest with progenitor differentiation during angiogenesis FASEB J. 2020-03-29 [PMID: 32223018]
Chen L, Wang Z, Xu Q et Al. The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma Theranostics 2020-02-18 [PMID: 32206108] (WB, Mouse)	WB	Mouse
Fabbri L, Dufies M, Lacas-Gervais S et Al. Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-deltaC in clear cell Renal Cell Carcinoma patients Theranostics 2020-02-03 [PMID: 32194829] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Park Jh, Kim Mj, Kim Wj et Al. Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models Cancer Lett. 2020-03-12 [PMID: 32173479] (WB, Human)	WB	Human
Sun X, Sun Bl, Babicheva A et Al. Direct eNAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling: Transcriptional Regulation by SOX and HIF2 alpha Am. J. Respir. Cell Mol. Biol. 2020-03-06 [PMID: 32142369]
Gojkovic M, Darmasaputra Gs, Velica P et Al. Deregulated hypoxic response in myeloid cells: A model for high-altitude pulmonary oedema (HAPE) Acta Physiol (Oxf) 2020-03-04 [PMID: 32129933] (ICC/IF, WB, Mouse)	ICC/IF, WB	Mouse
Sadaghianloo N, Contenti J, Dufies M et al. Co-culture of human fibroblasts, smooth muscle and endothelial cells promotes osteopontin induction in hypoxia J. Cell. Mol. Med. 2020-02-07 [PMID: 32032472] (WB, Human)	WB	Human
Roelants C, Pillet C, Franquet Q et al. Ex-Vivo Treatment of Tumor Tissue Slices as a Predictive Preclinical Method to Evaluate Targeted Therapies for Patients with Renal Carcinoma Cancers (Basel) 2020-01-17 [PMID: 31963500] (IF/IHC, Human)	IF/IHC	Human
Sivaraj KK, Dharmalingam B, Mohanakrishnan V et al. YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells Elife 2020-01-20 [PMID: 31958058] (ICC/IF, Mouse)	ICC/IF	Mouse
Brown E, Rowan C, Strowitzki MJ et al. Mucosal inflammation downregulates PHD1 expression promoting a barrier-protective HIF-1 alpha response in ulcerative colitis patients FASEB J. 2020-01-16 [PMID: 31944416] (WB, Human)	WB	Human
Senavirathna LK, Huang C, Pushparaj S et al. Hypoxia and transforming growth factor beta 1 regulation of long non-coding RNA transcriptomes in human pulmonary fibroblasts Physiol Rep 2020-01-01 [PMID: 31925944] (WB, Human)	WB	Human
Evagelou, S L, Bebenek, O Et al. DEAD Box Protein Family Member DDX28 Is a Negative Regulator of Hypoxia-Inducible Factor 2 alpha - and Eukaryotic Initiation Factor 4E2-Directed Hypoxic Translation. Mol Cell Biol 2020-02-27 [PMID: 31907278] (WB, Mouse)	WB	Mouse
Wierenga ATJ, Cunningham A, Erdem A et al. HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells Cancer & Metabolism 2019-12-27 [PMID: 31890203]
Jeon GW, Sheldon RA, Ferriero DM Hypoxia-inducible factor: role in cell survival in superoxide dismutase overexpressing mice after neonatal hypoxia-ischemia Korean J Pediatr 2019-12-01 [PMID: 31870086] (WB, Mouse)	WB	Mouse
Yoo HC, Park SJ, Nam M et al. A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells Cell Metab. 2019-12-13 [PMID: 31866442] (Chemotaxis, Human)	Chemotaxis	Human
Hart PC, Kenny HA, Grassl N, et al. Mesothelial Cell HIF1 alpha Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk Cell Rep 2019-12-17 [PMID: 31851935] (WB, Human)	WB	Human
Varghese J, Varghese James J, Karthikeyan M et al. Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease Journal of Trace Elements in Medicine and Biology 2019-11-01 [PMID: 31835128] (WB, Human)	WB	Human
Cannito S, Foglia B, Villano G et al. SerpinB3 Differently Up-Regulates Hypoxia Inducible Factors -1 alpha and -2 alpha in Hepatocellular Carcinoma: Mechanisms Revealing Novel Potential Therapeutic Targets Cancers (Basel) 2019-12-04 [PMID: 31817100] (WB, Human)	WB	Human
Lopez-Rodriguez D M, Kirillov V et al. A role of hypoxia-inducible factor 1 alpha in Mouse Gammaherpesvirus 68 (MHV68) lytic replication and reactivation from latency. PLoS Pathog 2019-06-12 [PMID: 31809522] (WB, Mouse)	WB	Mouse
Morikawa M, Mitani Y, Holmborn K et al. The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension Sci Signal 2019-11-12 [PMID: 31719172]
Doan H, Parsons A et al. HIF-mediated Suppression of DEPTOR Confers Resistance to mTOR Kinase Inhibition in Renal Cancer. iScience 2019-11-22 [PMID: 31710966] (WB, Human)	WB	Human
Tashiro N, Segawa R, Tobita R et al. Hypoxia inhibits TNF-alpha-induced TSLP expression in keratinocytes PLoS ONE 2019-11-04 [PMID: 31682627] (WB, Human, Mouse)	WB	Human, Mouse
Zhang X, Zhang Y, Wang P et al. Adipocyte Hypoxia-Inducible Factor 2 alpha Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism Cell Metab. 2019-10-23 [PMID: 31668872]
He C, Danes J M et al. SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer. Proc Natl Acad Sci U S A 2019-11-19 [PMID: 31591207] (WB, Human)	WB	Human
Han S, Huang T, Hou F et al. The prognostic value of hypoxia-inducible factor-1 alpha in advanced cancer survivors: a meta-analysis with trial sequential analysis Ther Adv Med Oncol 2019-09-24 [PMID: 31579115] (IHC-P, Human)	IHC-P	Human
Gao RY, Wang M, Liu Q et al. Hypoxia-Inducible Factor (HIF)-2 alpha Reprograms Liver Macrophages to Protect Against Acute Liver Injury via the Production of Interleukin-6 Hepatology 2019-09-17 [PMID: 31529728] (WB)	WB
Seo JB, Riopel M, Cabrales P et al. Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity Nat Metab [PMID: 31528845] (WB, Human)	WB	Human
Bennett L F, Liao C et al. Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C. Sci Signal 2019-10-09 [PMID: 31506384] (WB, Mouse)	WB	Mouse
David BT, Curtin JJ, Goldberg DC et al. Hypoxia Inducible Factor 1 alpha (HIF-1 alpha) counteracts the acute death of cells transplanted into the injured spinal cord eNeuro [PMID: 31488552] (WB)	WB
Schwartz AJ, Converso-Baran K, Michele DE, Shah YM A genetic mouse model of severe iron-deficiency anemia reveals tissue-specific transcriptional stress responses and cardiac remodeling J. Biol. Chem. 2019-08-15 [PMID: 31416832] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Novianti T, Juniantito V, Jusuf AA et al. Expression and role of HIF-1alpha and HIF-2alpha in tissue regeneration: a study of hypoxia in house gecko tail regeneration Organogenesis 2019-08-13 [PMID: 31409194] (IHC-P, WB, Reptile) Details: The role of HIF-1 alpha and HIF-2 alpha in overcoming hypoxia during tail autotomy in the Hemidactylus platyurus is explored.	IHC-P, WB	Reptile
Qi D, Wei M, Jiao S et al. Hypoxia inducible factor 1 alpha in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment Cell Death Dis 2019-07-18 [PMID: 31320613] (Chemotaxis, Mouse)	Chemotaxis	Mouse
Lee YS, Riopel M, Cabrales P, Bandyopadhyay GK, Hepatocyte-specific HIF-1 alpha ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation Sci Adv 2019-07-01 [PMID: 31281892] (WB, Mouse)	WB	Mouse
Aquino-Galvez A, Gonzalez-Avila G, Jimenez-Sanchez LL et al. Dysregulated expression of hypoxia-inducible factors augments myofibroblasts differentiation in idiopathic pulmonary fibrosis Respir. Res. 2019-06-24 [PMID: 31234835] (WB, Human)	WB	Human
Maugeri G, D'Amico AG, Federico C et al. Involvement of A3 Adenosine Receptor in Neuroblastoma Progression via Modulation of the Hypoxic/Angiogenic Pathway J. Mol. Neurosci. 2019-06-05 [PMID: 31166001] (WB, Human)	WB	Human
Yamamoto A, Hester J, Macklin PS, et al. Systemic silencing of PHD2 causes reversible immune regulatory dysfunction J. Clin. Invest. 2019-06-04 [PMID: 31162141] (WB, Mouse)	WB	Mouse
Kozlova N, Mennerich D, Samoylenko A et al. The pro-oncogenic adaptor CIN85 inhibits hypoxia-inducible factor prolyl hydroxylase-2. Cancer Res 2019-05-31 [PMID: 31142511] (WB, Human)	WB	Human
Fang C, Manes TD, Liu L et al. A RASSF1A-HIF1 alpha loop drives Warburg effect in cancer and pulmonary hypertension Nat Commun 2019-05-13 [PMID: 31086178] (WB, Human)	WB	Human
Liu M, Zhang L, Marsboom G, Jambusaria A et al. Sox17 is required for endothelial regeneration following inflammation-induced vascular injury Nat Commun 2019-05-09 [PMID: 31073164] (WB, Mouse)	WB	Mouse
Muenchau S, Deutsch R, de Castro IJ et al. Hypoxic Environment Promotes Barrier Formation in Human Intestinal Epithelial Cells through Regulation of MicroRNA 320a Expression Mol. Cell. Biol. 2019-07-15 [PMID: 31061092] (WB, KD, Human)	WB, KD	Human
Fujimoto TN, Colbert LE, Huang Y et al. Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer Cancer Res. 2019-05-01 [PMID: 31043430] (WB, Mouse)	WB	Mouse
Adamska A, Ferro R, Lattanzio R et al. Impact of Extrinsic and Intrinsic Hypoxia on Catecholamine Biosynthesis in Absence or Presence of Hif2-alpha in Pheochromocytoma Cells Cancers (Basel) 2019-04-28 [PMID: 31035382] (IHC-P, WB, Mouse)	IHC-P, WB	Mouse
Chaurasia, SN;Kushwaha, G;Kulkarni, PP;Mallick, RL;Latheef, NA;Mishra, JK;Dash, D; Platelet HIF-2 alpha promotes thrombogenicity through PAI-1 synthesis and extracellular vesicle release Haematologica 2019-04-19 [PMID: 31004026] (WB, Human)	WB	Human
Sumi Chisato, Matsuo Yoshiyuki, Kusunoki Munenori et al. Cancerous phenotypes associated with hypoxia-inducible factors are not influenced by the volatile anesthetic isoflurane in renal cell carcinoma. PloS One 2019-04-15 [PMID: 30986231] (Human)		Human
Sumi C, Matsuo Y, Iwai T et al. In renal cell carcinoma, cancerous phenotypes linked to hypoxia-inducible factors are insensitive to the volatile anesthetic isoflurane bioRxiv 2018-07-25 [PMID: 30986231] (WB, Human)	WB	Human
Gkotinakou, IM;Befani, C;Simos, G;Liakos, P; ERK1/2 phosphorylates HIF-2 alpha and regulates its activity by controlling its CRM1-dependent nuclear shuttling J. Cell. Sci. 2019-04-08 [PMID: 30962349] (WB, Human)	WB	Human
Chang Song Ho, Mori Daisuke, Kobayashi Hiroshi et al. Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF- kappa B pathway. Frontiers in Immunology 2019-03-29 [PMID: 30926814] (IHC-P, Mouse)	IHC-P	Mouse
Chachami, G;Stankovic-Valentin, N;Karagiota, A;Basagianni, A;Plessmann, U;Urlaub, H;Melchior, F;Simos, G; Hypoxia-induced changes in SUMO conjugation affect transcriptional regulation under low oxygen Mol. Cell Proteomics 2019-03-29 [PMID: 30926672] (WB, Human)	WB	Human
Arthur SA, Blaydes JP, Houghton FD. Glycolysis Regulates Human Embryonic Stem Cell Self-Renewal under Hypoxia through HIF-2 alpha and the Glycolytic Sensors CTBPs Stem Cell Reports 2019-03-01 [PMID: 30880076] (WB, Human)	WB	Human
Natarajan S, Foreman KM, Soriano MI et al. Collagen remodeling in the hypoxic tumor-mesothelial niche promotes ovarian cancer metastasis Cancer Res. 2019-03-12 [PMID: 30862717] (IF/IHC, Human)	IF/IHC	Human
Syafruddin SE, Rodrigues P, Vojtasova E et al. A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma Nat Commun 2019-03-11 [PMID: 30858363] (Chemotaxis, Human)	Chemotaxis	Human
Halvarsson C, Rorby E, Eliasson P et al. Putative role of NF-kappa B but not HIF-1alpha in hypoxia-dependent regulation of oxidative stress in hematopoietic stem and progenitor cells Antioxid. Redox Signal. 2019-03-02 [PMID: 30827134] (WB, Mouse)	WB	Mouse
Ndiaye PD, Dufies M, Giuliano S et al. VEGFC acts as a double-edged sword in renal cell carcinoma aggressiveness Theranostics 2019-01-21 [PMID: 30809300] (WB, Human)	WB	Human
Laitakari A, Ollonen T, Kietzmann T et al. Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease Redox Biol 2019-02-19 [PMID: 30802717] (WB, Mouse)	WB	Mouse
Xiong Y, Liu L, Xia Y et al. Tumor infiltrating mast cells determine oncogenic HIF-2a-conferred immune evasion in clear cell renal cell carcinoma Cancer Immunol. Immunother. 2019-02-13 [PMID: 30758643] (IHC-P, Human)	IHC-P	Human
Hong B, Zhou J, Ma K et al. TRIB3 Promotes the Proliferation and Invasion of Renal Cell Carcinoma Cells via Activating MAPK Signaling Pathway. Int. J. Biol. Sci. 2019-01-08 [PMID: 30745845] (WB, Human)	WB	Human
Lee BJ, Jun HO, Kim JH, Kim JH. Astrocytic cystine/glutamate antiporter is a key regulator of erythropoietin expression in the ischemic retina FASEB J. 2019-02-11 [PMID: 30742774] (WB, Human)	WB	Human
Tian Z, Yao L, Shen Y et al. Histone H3K9 demethylase JMJD1A is a co-activator of erythropoietin expression under hypoxia Int. J. Biochem. Cell Biol. 2019-04-01 [PMID: 30716474] (WB, Human)	WB	Human
Jarman EJ, Ward C, Turnbull AK et al. HER2 regulates HIF-2a and drives an increased hypoxic response in breast cancer. Breast Cancer Res. 2019-01-22 [PMID: 30670058] (WB, Human)	WB	Human
Ma X, Das NK, Castillo C et al. SMAD family member 3 (SMAD3) and SMAD4 repress HIF2a-dependent iron-regulatory genes. J. Biol. Chem. 2019-01-18 [PMID: 30659096] (WB, Human)	WB	Human
Guo H, Ci X, Ahmed M et al. ONECUT2 is a driver of neuroendocrine prostate cancer. Nat Commun 2019-01-17 [PMID: 30655535] (Chemotaxis, Human)	Chemotaxis	Human
Santana-Codina N, Gableske S, Quiles Del Rey M et al. NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms. Haematologica 2019-01-10 [PMID: 30630985] (WB, Mouse)	WB	Mouse
Olcina MM, Balanis NG, Kim RK et al. Mutations in an Innate Immunity Pathway Are Associated with Poor Overall Survival Outcomes and Hypoxic Signaling in Cancer Cell Rep 2018-12-26 [PMID: 30590044] (WB, Human)	WB	Human
Karagiota A, Kourti M, Simos G, Mylonis I. HIF-1a-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia Cell. Mol. Life Sci. 2018-12-10 [PMID: 30535970] (WB, Human)	WB	Human
Choi SA, Kim YH, Park YH et al. Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis. Cell Death Differ. 2018-11-21 [PMID: 30464227] (ICC/IF, Mouse)	ICC/IF	Mouse
Murahashi Y, Yano F, Kobayashi H et al. Intra-articular administration of IkBa kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-kB/HIF-2a axis. Sci Rep. 2018-11-07 [PMID: 30405206] (IHC-P, Mouse)	IHC-P	Mouse
Deygas M, Gadet R, Gillet G et al. Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen. Nat Commun. 2018-10-31 [PMID: 30382089] (WB, Human)	WB	Human
Liao L, Liu ZZ, Langbein L et al. Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer. Elife. 2018-10-25 [PMID: 30355451] (WB, Human)	WB	Human
Schwartz AJ, Das Nk, Ramakrishnan Sk et al. Hepatic hepcidin/intestinal HIF-2a axis maintains iron absorption during iron deficiency and overload. J. Clin. Invest. 2018-10-23 [PMID: 30352047] (Mouse)		Mouse
Carolina E, kato T, khanh VC et al. Glucocorticoid Impaired the Wound Healing Ability of Endothelial Progenitor Cells by Reducing the Expression of CXCR4 in the PGE2 Pathway. Front Med (Lausanne). 2018-09-28 [PMID: 30324106] (WB, Human)	WB	Human
Fortenbery GW, Sarathy B, Carraway kR, Mansfield kD. Hypoxic stabilization of mRNA is HIF-independent but requires mtROS. Cell. Mol. Biol. Lett. 2018-10-04 [PMID: 30305827] (WB, Human)	WB	Human
Sethuraman A, Brown M, krutilina R et al. BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion. Breast Cancer Res. 2018-10-01 [PMID: 30285805] (WB, Human)	WB	Human
Hulea L, Gravel SP, Morita M et al. Translational and HIF-1a-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides. Cell Metab. 2018-09-17 [PMID: 30244971] (B/N)	B/N
Xu M, Tan X, Li N et al. Differential regulation of estrogen in iron metabolism in astrocytes and neurons J. Cell. Physiol. 2018-08-21 [PMID: 30132882] (WB, Rat)	WB	Rat
Zaini MN, Patel SA, Syafruddin SE et al. Endogenous HIF2A reporter systems for high-throughput functional screening Sci Rep 2018-08-13 [PMID: 30104738] (WB, Human)	WB	Human
Anea C, Merloiu A, Fulton D et al. Immunohistochemistry of the circadian clock in mouse and human vascular tissues. VP 2018-07-20 [PMID: 30101218] (IF/IHC, Mouse)	IF/IHC	Mouse
Regan Anderson TM, Ma S, Perez kerkvliet C et al. Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis. Mol. Cancer Res. 2018-07-10 [PMID: 29991529] (WB, Human)	WB	Human
Kumar VP, Biswas S, Sharma NK et al. PEGylated IL-11 (BBT-059): A Novel Radiation Countermeasure for Hematopoietic Acute Radiation Syndrome Health Phys 2018-07-01 [PMID: 29787432] (WB, Mouse)	WB	Mouse
Landau D, London L, Bandach I, Segev Y. The hypoxia inducible factor/erythropoietin (EPO)/EPO receptor pathway is disturbed in a rat model of chronic kidney disease related anemia PLoS ONE 2018-05-08 [PMID: 29738538] (WB, Rat)	WB	Rat
Schofield HK, Tandon M, Park M et al. Pancreatic HIF2 alpha stabilization leads to chronic pancreatitis and predisposes to mucinous cystic neoplasm Cellular and Molecular Gastroenterology and Hepatology 2017-11-10 [PMID: 29693047] (WB, Mouse)	WB	Mouse
Marinaccio C Myeloproliferative Neoplasms: From Biology to Targeted Therapeutics Thesis 2021-01-01
Miess H, Dankworth B, Gouw AM et al. The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma Oncogene 2018-06-05 [PMID: 29872221] (WB, Human)	WB	Human
Yang Q, Guo X, Yang L. Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2a (HIF-2a) and 30 kDa HIV Tat-Interacting Protein (TIP30). Med. Sci. Monit. 2018-04-14 [PMID: 29654226] (WB)	WB
Ferecatu I, Canal F, Fabbri L et al. Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1a activation. PLoS ONE 2018-03-29 [PMID: 29596470] (WB, Human)	WB	Human
Teitelbaum D Laminar Flow Blunts Hypoxia Signaling in Endothelial Cells: Relevance for the Venous Circulation Thesis (WB, Human)	WB	Human
Thompson JM, Alvarez A, Singha MK et al. Targeting the mevalonate pathway suppresses VHL-deficient CC-RCC through a HIF-dependent mechanism Mol. Cancer Ther. 2018-05-02 [PMID: 29720560] (Mouse)		Mouse
Maugeri G, D'Amico AG, Rasa DM et al. PACAP and VIP regulate hypoxia-inducible factors in neuroblastoma cells exposed to hypoxia. Neuropeptides 2018-06-01 [PMID: 29699729] (Human)		Human
Xie L, Yin A, Nichenko AS et al. Transient HIF2A inhibition promotes satellite cell proliferation and muscle regeneration. J. Clin. Invest. 2018-03-13 [PMID: 29533927] (WB)	WB
Kim H, Lin Q, Glazer PM, Yun Z. The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells. Breast Cancer Res. 2018-03-06 [PMID: 29510720] (WB, Human)	WB	Human
Abdul-Aziz AM, Shafat MS, Sun Y et al. HIF1A drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia. Oncogene. 2018-02-28 [PMID: 29487418] (WB)	WB
Ambrosetti D, Dufies M, Dadone B et al. The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma. PLoS ONE. 2018-02-26 [PMID: 29481555] (IF/IHC, Human)	IF/IHC	Human
Robinson CM, Lefebvre F, Poon BP, Bousard A. Consequences of VHL Loss on Global DNA Methylome. Sci Rep. 2018-02-20 [PMID: 29463811] (GS, Human)	GS	Human
Senavirathna LK, Huang C, Yang X, Munteanu MC. Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling. Sci Rep. 2018-02-09 [PMID: 29426911] (WB, Human)	WB	Human
Mira E, Carmona-Rodriguez L, Perez-Villamil B, Casas J. SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2a. Nat Commun. 2018-02-08 [PMID: 29422508] (WB, Human)	WB	Human
Frump AL, Selej M, Wood JA, Albrecht M. Hypoxia Up-regulates Estrogen Receptor b in Pulmonary Artery Endothelial Cells in a HIF-1a Dependent Manner. Am. J. Respir. Cell Mol. Biol. 2018-02-02 [PMID: 29394091] (Rat)		Rat
Liu S, Tetzlaff MT, Wang T et al. Hypoxia-activated prodrug enhances therapeutic effect of sunitinib in melanoma Oncotarget 2017-12-29 [PMID: 29383148] (WB, Mouse)	WB	Mouse
Samanta D, Park Y, Ni X et al. Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells Proc. Natl. Acad. Sci. U.S.A. 2018-01-24 [PMID: 29367423] (Chemotaxis, Human) Details: This citation used the Alexa Fluor 488 form of this antbody	Chemotaxis	Human
Maybin Jacqueline A, Murray Alison A, Saunders Philippa T K et al. Hypoxia and hypoxia inducible factor-1a are required for normal endometrial repair during menstruation. Nat Commun 2018-01-01 [PMID: 29362355] (WB, Mouse)	WB	Mouse
Dopeso H, Jiao HK, Cuesta AM et al. PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFalpha. Cancer Res 2018-04-01 [PMID: 29339541]
Bogurcu N, Seidel S, Garvalov BK, Acker T. Analysis of Hypoxia and the Hypoxic Response in Tumor Xenografts Methods Mol. Biol. 2018-01-14 [PMID: 29330809] (WB)	WB
Brooks DL, Seagroves TN. Chromatin Immunoprecipitation of HIF-a in Breast Tumor Cells Using Wild Type and Loss of Function Models Methods Mol. Biol. 2018-01-14 [PMID: 29330791] (IP)	IP
Ho JJD, Balukoff NC, Cervantes G, Malcolm PD. Oxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B. Cell Rep. 2018-01-02 [PMID: 29298419] (WB)	WB
Tojo K, Tamada N, Nagamine Y et al. Enhancement of glycolysis by inhibition of oxygen-sensing prolyl hydroxylases protects alveolar epithelial cells from acute lung injury. FASEB J 2018-01-05 [PMID: 29233858] (Mouse)		Mouse
Robrahn L, Dupont A, Jumpertz S, et al. Conditional deletion of HIF-1 alpha provides new insight regarding the murine response to gastrointestinal infection with Salmonella Typhimurium bioRxiv 2021-01-17 (WB, Mouse)	WB	Mouse
Morello, E, Sutti, S Et al. Hypoxia-inducible factor 2 alpha drives nonalcoholic fatty liver progression by triggering hepatocyte release of histidine-rich glycoprotein. Hepatology 2018-06-01 [PMID: 29266399] (IHC-Fr, WB, Human)	IHC-Fr, WB	Human
Gastelum Gilberto, Poteshkina Aleksandra, Veena Mysore et al. RestoRation of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2a expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis. PloS One 2017-01-01 [PMID: 29206844] (WB, Mouse)	WB	Mouse
Jung J, Sosnowska D, Weaver J et al. Expression of Hypoxia-Inducible Factors in Different Stages of Pancreatic Tumor Progression Reports 2020-10-15 (IF/IHC, Human)	IF/IHC	Human
Backer V, Cheung FY, Siveke JT et al. Knockdown of myeloid cell hypoxia-inducible factor-1a ameliorates the acute pathology in DSS-induced colitis. PLoS ONE 2017-12-20 [PMID: 29261815] (IHC-P, Mouse)	IHC-P	Mouse
Shi M, Flores B, Li P et al. Effects of Erythropoietin Receptor Activity on Angiogenesis, Tubular Injury and Fibrosis in Acute Kidney Injury: A U-Shaped Relationship. Am. J. Physiol. Renal Physiol. 2017-11-29 [PMID: 29187371] (Mouse)		Mouse
Du W, Zhang L, Brett-Morris A et al. HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism Nat Commun. 2017-11-24 [PMID: 29176561] (WB, Human)	WB	Human
Ho JC, Abdullah LN, Pang QY et al. Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway PLoS ONE. 2017-11-16 [PMID: 29145444] (WB, Human)	WB	Human
Bino L, Prochazkova J, Radaszkiewicz KA et al. Hypoxia favors myosin heavy chain beta gene expression in an Hif-1alpha-dependent manner Oncotarget. 2017-10-13 [PMID: 29137374] (WB, Mouse)	WB	Mouse
Palazon A, Tyrakis PA, Macias D et al. An HIF-1 alpha/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression Cancer Cell 2017-11-13 [PMID: 29136509] (WB, Mouse)	WB	Mouse
Fanelli G, Gonzalez-Cordero A, Gardner PJ et al. Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress Sci Rep 2017-11-07 [PMID: 29116192] (IF/IHC, Human)	IF/IHC	Human
Hascoet P, Chesnel F, Jouan F et al. The pVHL172 isoform is not a tumor suppressor and up-regulates a subset of pro-tumorigenic genes including TGFB1 and MMP13 Oncotarget 2017-09-29 [PMID: 29100286] (IB, Human)	IB	Human
Casillas AL, Toth RK, Sainz AG et al. Hypoxia-inducible PIM kinase expression promotes resistance to anti-angiogenic agents Clin. Cancer Res. 2017-10-30 [PMID: 29084916] (Human)		Human
Tang H, Babicheva A, McDermott KM et al. Endothelial HIF-2a Contributes to Severe Pulmonary Hypertension by Inducing Endothelial-to-Mesenchymal Transition. Am. J. Physiol. Lung Cell Mol. Physiol. 2017-10-26 [PMID: 29074488] (WB, Human)	WB	Human
Xie Cen, Yagai Tomoki, Luo Yuhong et al. Activation of intestinal hypoxia-inducible factor 2 alpha during obesity contributes to hepatic steatosis. Nature Medicine 2017-11-01 [PMID: 29035368] (WB)	WB
Strowitzki MJ, Ritter AS, Radhakrishnan P et al. Pharmacological HIF-inhibition attenuates postoperative adhesion formation. Sci Rep. 2017-10-13 [PMID: 29030625] (WB, Mouse) Details: HIF1 alpha antibody used to show the effect on cells of YC-1 exposure in both normoxic and hypoxic by western blot in mouseNIH/3T3 cells	WB	Mouse
He X, Zeng H, Chen ST et al. Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction J. Mol. Cell. Cardiol. 2017-09-19 [PMID: 28935506] (WB, Mouse)	WB	Mouse
Liu Z, Yan S, Wang J et al. Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis Nat Commun 2017-09-19 [PMID: 28928465] (WB, Human)	WB	Human
Ariazi JL, Duffy KJ, Adams DF et al. Discovery and Preclinical Characterization of GSK1278863 (daprodustat), A Small Molecule Hypoxia Inducible Factor (HIF)-Prolyl Hydroxylase Inhibitor for Anemia. J. Pharmacol. Exp. Ther. 2017-09-19 [PMID: 28928122] (WB, Human)	WB	Human
Kong KH, Oh HJ, Lim BJ et al. Selective tubular activation of hypoxia-inducible factor-2a has dual effects on renal fibrosis Sci Rep 2017-09-12 [PMID: 28900259] (WB, Mouse)	WB	Mouse
Dobrynin G, McAllister TE, Leszczynska KB et al. KDM4A regulates HIF-1 levels through H3K9me3 Sci Rep 2017-09-11 [PMID: 28894274] (WB, Human)	WB	Human
Yao X, Tan J, Lim KJ et al. VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma Cancer Discov 2017-09-11 [PMID: 28893800] (WB)	WB
Ma X, Zhang H, Xue X, Shah YM. Hypoxia-inducible factor 2a (HIF-2a) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity J. Biol. Chem. 2017-08-28 [PMID: 28848049] (Mouse)		Mouse
Shved N, Warsow G, Eichinger F et al. Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts Sci Rep 2017-08-17 [PMID: 28819298] (WB, Human)	WB	Human
McGinn O, Gupta VK, Dauer P et al. Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer Sci Rep 2017-08-11 [PMID: 28801636] (WB, Human)	WB	Human
Tsang KM, Hyun JS, Cheng KT et al. Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1alpha Stem Cell Reports 2017-07-24 [PMID: 28781077] (WB, Mouse)	WB	Mouse
Sun W, Kato H, Kitajima S et al. Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression. Sci Rep 2017-08-03 [PMID: 28775317] (WB, Human)	WB	Human
Bhan A, Deb P, Shihabeddin N et al. Histone methylase MLL1 coordinates with HIF and regulate lncRNA HOTAIR expression under hypoxia Gene 2017-09-20 [PMID: 28756022] (Chemotaxis, Human)	Chemotaxis	Human
Jain CV, Jessmon P, Barrak CT et al. Trophoblast survival signaling during human placentation requires HSP70 activation of MMP2-mediated HBEGF shedding Cell Death Differ. 2017-07-21 [PMID: 28731464] (WB)	WB
Sato H, Uzu M et al. Sodium butyrate enhances the growth inhibitory effect of sunitinib in human renal cell carcinoma cells. Oncol Lett 2017-01-07 [PMID: 28693255] (WB, Human)	WB	Human
Lim E, Kuo CC, Tu HF, Yang CC. The prognosis outcome of oral squamous cell carcinoma using HIF-2alpha J Chin Med Assoc 2017-07-06 [PMID: 28690120] (IHC-P, Human)	IHC-P	Human
Okamoto A, Sumi C, Tanaka H et al. HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death. Sci Rep. 2017-06-19 [PMID: 28630416]
Yasui T, Uezono N, Nakashima H et al. Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells. Stem Cell Reports. 2017-06-06 [PMID: 28591654] (Human)		Human
Wu D, Huang RT, Hamanaka RB et al. HIF-1alpha is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium. Elife. 2017-05-30 [PMID: 28556776] (WB, FLOW, Human)	WB, FLOW	Human
Salati S, Salvestrini V, Carretta C et al. Deregulated expression of miR-29a-3p, miR-494-3p and miR-660-5p affects sensitivity to tyrosine kinase inhibitors in CML leukemic stem cells Oncotarget 2017-07-25 [PMID: 28533480] (WB, Human)	WB	Human
Harashima N, Takenaga K, Akimoto M, Harada M. HIF-2 alpha dictates the susceptibility of pancreatic cancer cells to TRAIL by regulating survivin expression Oncotarget 2017-06-27 [PMID: 28476028] (WB, Human)	WB	Human
Sun L, Kong Y, Cao M et al. Decreased expression of acetyl-CoA synthase 2 promotes metastasis and predicts poor prognosis in hepatocellular carcinoma Cancer Sci. 2017-07-01 [PMID: 28387999] (WB, Human)	WB	Human
Lee H, Liu S, Lin C et al. A Crucial Role of CXCL14 for Promoting Regulatory T Cells Activation in Stroke. Theranostics 2. 2017-02-08 [PMID: 28382159] (WB, IF/IHC, Rat)	WB, IF/IHC	Rat
Wang S, Zeng H, Chen ST et al. Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice. J. Cell. Mol. Med. 2017-03-07 [PMID: 28266128] (WB, Mouse)	WB	Mouse
Lu H, Chen I, Shimoda LA et al. Chemotherapy-Induced Ca 2+ Release Stimulates Breast Cancer Stem Cell Enrichment Cell Rep. 2017-02-21 [PMID: 28228260] (WB, Chemotaxis, Human) Details: The positive impact of HIF inhibitors on breast cancer chemotherapy is explored through GSTO1 knockdown.	WB, Chemotaxis	Human
Luo S, Li Y, Ma R et al. Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma. Oncogene. 2017-02-06 [PMID: 28166201]
Kuan II, Liang KH, Wang YP et al. EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2alpha. Sci Rep. 2017-02-03 [PMID: 28157205]
Hoppe-Seyler K, Bossler F, Lohrey C et al. Induction of dormancy in hypoxic human papillomavirus-positive cancer cells Proc. Natl. Acad. Sci. U.S.A 2017-01-23 [PMID: 28115701] (IB, Human)	IB	Human
Gardner PJ, Liyanage SE, Cristante E et al. Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye Sci Rep 2017-01-23 [PMID: 28112274] (WB, Mouse)	WB	Mouse
Yamamura K, Uruno T, Shiraishi A et al. The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction Nat Commun 2017-01-09 [PMID: 28067314] (ICC/IF, Mouse)	ICC/IF	Mouse
Kozlova N, Wottawa M, Katschinski DM et al. Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer. Oncotarget 2017-02-07 [PMID: 28038470]
Shneor D, Folberg R, Pe'er J et al. Stable knockdown of CREB, HIF-1 and HIF-2 by replication-competent retroviruses abrogates the responses to hypoxia in hepatocellular carcinoma. Cancer Gene Ther. 2016-12-09 [PMID: 27934882] (WB, Human)	WB	Human
Chen T, Zhou Q, et al. miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation. J Am Heart Assoc 2016-12-05 [PMID: 27919930] (WB, Mouse)	WB	Mouse
Nakayama T, Otsuka S, Kobayashi T et al. Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy. Sci Rep. 2016-11-18 [PMID: 27857072] (WB, Human)	WB	Human
Thompson JM, Nguyen QH, Singh M et al. Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma. Oncogene. 2016-11-14 [PMID: 27841867]
Zhang L, Du J, Justus S et al. Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration. J. Clin. Invest. 2016-12-01 [PMID: 27841758] (WB, Mouse)	WB	Mouse
Isono T, Chano T, Yoshida T et al. Hydroxyl-HIF2-alpha is potential therapeutic target for renal cell carcinomas. Am J Cancer Res. 2016-11-08 [PMID: 27822416] (Human)		Human
Ke S, Chen S, Dong Z et al. Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations. Hepatology. 2016-10-24 [PMID: 27774607]
Ha JH, Doguer C, Collins JF. Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells. Metallomics. 2016-08-22 [PMID: 27714044]
D'Alessio A, Proietti G, Lama G et al. Analysis of angiogenesis related factors in glioblastoma, peritumoral tissue and their derived cancer stem cells. Oncotarget. 2016-11-29 [PMID: 27705944] (IF/IHC, Human)	IF/IHC	Human
Pangou E, Befani C, Mylonis I et al. HIF-2alpha phosphorylation by CK1delta promotes erythropoietin secretion in liver cancer cells under hypoxia. J. Cell. Sci. 2016-11-15 [PMID: 27686097]
Dehn S, DeBerge M, Yeap X et al. HIF-2a in Resting Macrophages Tempers Mitochondrial ROS to Selectively Repress MARCO-dependent Phagocytosis. J Immunol. 2016-11-01 [PMID: 27671111] (WB, Mouse)	WB	Mouse
Wang S, Zeng H, Xie XJ et al. Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling. Oncotarget. 2016-09-13 [PMID: 27613846] (WB, Mouse)	WB	Mouse
Gortz Ge, Horstmann M, Aniol B et al. Hypoxia-dependent HIF-1 activation impacts on tissue remodeling in Graves' ophthalmopathy - implications for smoking. J. Clin. Endocrinol. Metab. 2016-09-09 [PMID: 27610652]
Frey H, Moreth K, Hsieh LT et al. A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia Glycoconjugate Journal 2017-06-01 [PMID: 27600268] (ELISA, WB)	ELISA, WB
Zhang C, Zhi WI, Lu H et al. Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells. Oncotarget. 2016-08-31 [PMID: 27590511] (WB, Human)	WB	Human
Prakash H, Nadella V, Singh S, Schmitz-Winnenthal H. CD14/TLR4 priming potentially recalibrates and exerts anti-tumor efficacy in tumor associated macrophages in a mouse model of pancreatic carcinoma. Sci Rep. 2016-08-11 [PMID: 27511884]
Gstalder C, Ader I, Cuvillier O. FTY720 (Fingolimod) inhibits HIF-1 and HIF-2 signaling, promotes vascular remodeling and chemosensitizes in renal cell carcinoma animal model. Mol. Cancer Ther. 2016-08-09 [PMID: 27507852] (WB)	WB
Nauta TD, Duyndam MC, Weijers EM et al. HIF-2alpha Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells. PLoS ONE. 2016-08-05 [PMID: 27490118] (WB, Human)	WB	Human
Depner C, Zum Buttel H, Bourcu N et al. EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance. Nat Commun. 2016-07-29 [PMID: 27470974] (WB)	WB
Leinonen H, Rossi M, Salo AM et al. Lack of P4H-TM in mice results in age-related retinal and renal alterations. Hum. Mol. Genet. 2016-07-27 [PMID: 27466183] (WB, Mouse)	WB	Mouse
Cui J, Duan B, Zhao X et al. MBD3 mediates epigenetic regulation on EPAS1 promoter in cancer. Tumour Biol 2016-10-01 [PMID: 27465550] (Human)		Human
Pramono A, Zahabi A, Morishima T et al. Thrombopoietin induces hematopoiesis from mouse ES cells via HIF-1a-dependent activation of a BMP4 autoregulatory loop Ann. N. Y. Acad. Sci. 2016-07-01 [PMID: 27447537] (WB, Mouse)	WB	Mouse
Chen H, Hong F, Chen Y et al. Activation of islet 5-HT4 receptor regulates glycemic control through promoting insulin secretion Eur. J. Pharmacol. 2016-07-13 [PMID: 27423314]
Luo B, Wang J, Liu Z et al. Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution. Nat Commun. [PMID: 27397585] (WB) Details: Citation using the HRP form of this antibody.	WB
Nunomiya A, Shin J, Kitajima Y et al. Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice. Acta Physiol (Oxf) 2016-07-09 [PMID: 27393382]
Lee MC, Huang HJ, Chang TH et al. Genome-wide analysis of HIF-2alpha chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions. Sci Rep 2016-07-04 [PMID: 27373565] (WB)	WB
Mandl M, Lieberum MK, Depping R. A HIF-1alpha-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT. Cell Death Dis 2016-06-30 [PMID: 27362802] (WB)	WB
Diaz-Trelles R, Scimia MC, Bushway P et al. Notch-independent RBPJ controls angiogenesis in the adult heart. Nat Commun 2016-06-30 [PMID: 27357444] (WB)	WB
Kowitzke B, Cohrs G, Leuschner I et al. Cellular Profiles and Molecular Mediators of Lesion Cascades in the Placode in Human Open Spinal Neural Tube Defects. J Neuropathol Exp Neurol 2016-09-01 [PMID: 27354486] (Human)		Human
Mao XG, Wang C, Liu DY et al. Hypoxia upregulates HIG2 expression and contributes to bevacizumab resistance in glioblastoma Oncotarget 2016-07-26 [PMID: 27329597] (Chemotaxis, Human)	Chemotaxis	Human
Higashimura Y, Kitakaze T, Harada N et al. pVHL-mediated degradation of HIF-2a regulates estrogen receptor a expression in normoxic breast cancer cells. FEBS Lett. 2016-06-21 [PMID: 27323688] (WB, Human)	WB	Human
Zhang X, Prasadam I, Fang W et al. Chondromodulin-1 ameliorates osteoarthritis progression by inhibiting HIF-2 alpha activity. Osteoarthr. Cartil. 2016-06-16 [PMID: 27321194] (IF/IHC)	IF/IHC
Maugeri G, Grazia D'Amico A, Reitano R et al. PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Front Pharmacol 2016-05-31 [PMID: 27303300] (WB)	WB
Mahara S, Lee PL, Feng M et al. HIFI-a activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer. Proc. Natl. Acad. Sci. U.S.A. 2016-06-28 [PMID: 27303043] (WB, Human)	WB	Human
Hoefflin R, Lahrmann B, Warsow G et al. Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity. Nat Commun 2016-06-13 [PMID: 27291893] (IF/IHC)	IF/IHC
Hoang NT, Kadonosono T, Kuchimaru T, Kizaka-Kondoh S Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model. Cancer Sci 2016-08-01 [PMID: 27270607] (WB)	WB
Mammadzada P, Gudmundsson J, Kvanta A, Andre H. Differential hypoxic response of human choroidal and retinal endothelial cells proposes tissue heterogeneity of ocular angiogenesis Acta Ophthalmol. [PMID: 27255568] (WB, Human)	WB	Human
Rodriguez S, Rudloff S, Koenig KF et al. Bidirectional signalling between EphA2 and ephrinA1 increases tubular cell attachment, laminin secretion and modulates erythropoietin expression after renal hypoxic injury. Pflugers Arch. 2016-05-26 [PMID: 27228995] (ICC/IF, WB, Rat)	ICC/IF, WB	Rat
Warfel NA, Sainz AG, Song JH, Kraft AS. PIM kinase inhibitors kill hypoxic tumor cells by reducing Nrf2 signaling and increasing reactive oxygen species. Mol. Cancer Ther. 2016-05-16 [PMID: 27196781] (WB, Human)	WB	Human
Christinat Y, Pawlowski R, Krek W. jSplice: a high-performance method for accurate prediction of alternative splicing events and its application to large-scale renal cancer transcriptome data. Bioinformatics 2016-07-15 [PMID: 27153587]
Dai Z, Li M, Wharton J et al. Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2a. Circulation 2016-06-14 [PMID: 27143681] (WB, Mouse)	WB	Mouse
Fitzpatrick SF, Fabian Z, Schaible B et al. Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-kB-dependent manner. Biochem. Biophys. Res. Commun. 2016-04-26 [PMID: 27130823] (WB, Human)	WB	Human
Selfridge AC, Cavadas MA, Scholz CC et al. Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia. J. Biol. Chem. 2016-05-27 [PMID: 27044749] (WB, Mouse, Human)	WB	Mouse, Human
Timpano S, Uniacke J. Human Cells Cultured under Physiological Oxygen Utilize Two Cap-binding Proteins to recruit Distinct mRNAs for Translation. J Biol Chem 2016-05-13 [PMID: 27002144]
Zhang C, Samanta D, Lu H et al. Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA. Proc Natl Acad Sci U S A. 2016-03-21 [PMID: 27001847] (WB, Human)	WB	Human
Nam H, Jones D, Cooksey RC et al. Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver. Diabetes 2016-06-01 [PMID: 26993063] (WB, Human)	WB	Human
German P, Bai S, Liu XD et al. Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function. Oncogene 2016-09-22 [PMID: 26973240]
You A, Cao M, Guo Z et al. Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models. J Hematol Oncol 2016-03-08 [PMID: 26957312] (WB)	WB
Zeng H, He X, Tuo QH et al. LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2alpha/Notch3 pathways. Sci Rep. 2016-02-12 [PMID: 26868537] (WB, Mouse, Human)	WB	Mouse, Human
Mori H, Yao Y, Learman BS et al. Induction of WNT11 by hypoxia and hypoxia-inducible factor-1alpha regulates cell proliferation, migration and invasion. Sci Rep. 2016-02-10 [PMID: 26861754] (WB, Human)	WB	Human
Heir P, Srikumar T, Bikopoulos G et al. Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling. J Biol Chem 2016-04-01 [PMID: 26846855]
Nakazawa MS, Eisinger-Mathason TS, Sadri N et al. Epigenetic re-expression of HIF-2alpha suppresses soft tissue sarcoma growth. Nat Commun 2016-02-03 [PMID: 26837714] (WB)	WB
Luo W, Chen I, Chen Y et al. PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia Oncotarget. 2016-02-09 [PMID: 26837221] (WB) Details: The mechanism for feedback inhibition of hypoxia-inducible factors during prolonged hypoxia is clarified through studying the interaction of PRDX2 and PRDX4 with HIF-1 alpha and HIF-2 alpha.	WB
Regan Anderson TM, Ma SH, Raj GV et al. Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer Cancer Res. 2016-01-29 [PMID: 26825173] (WB, Chemotaxis, Human)	WB, Chemotaxis	Human
Kadam PD, Chuan HH. Erratum to: Rectocutaneous fistula with transmigration of the suture: a rare delayed complication of vault fixation with the sacrospinous ligament. Int Urogynecol J. 2016-03-01 [PMID: 26811110] Details: This citation used the HRP version of this antibody.
Qian F, He M, Duan W et al. Cross regulation between hypoxia-inducible transcription factor-1alpha (HIF-1alpha) and transforming growth factor (TGF)-ss1 mediates nickel oxide nanoparticles (NiONPs)-induced pulmonary fibrosis. Am J Transl Res 2015-01-01 [PMID: 26807184] (WB)	WB
Mysore VS, Szablowski J, Dervan PB, Frost PJ. A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity. Mol Cancer Res. [PMID: 26801054] (WB, Human)	WB	Human
Kim Y, Nam HJ, Lee J et al. Methylation-dependent regulation of HIF-1alpha stability restricts retinal and tumour angiogenesis. Nat Commun 2016-01-13 [PMID: 26757928]
Chen K, Zeng J, Xiao H et al. Regulation of glucose metabolism by p62/SQSTM1 through HIF1alpha. J. Cell. Sci. 2016-01-07 [PMID: 26743088] (WB, Human) Details: HIF-2 alpha/EPAS1 was used at 1:500 dilution for WB assays in experiments involving human kidney cell lines namely ACHN, Caki-1 and HEK293T.	WB	Human
Bino L, Kucera J, Stefkova K et al. The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells. Chem Biol Interact 2016-01-25 [PMID: 26723917]
Messai Y, Gad S, Noman MZ et al. Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel-Lindau Gene Mutation Status. Eur. Urol. 2015-12-17 [PMID: 26707870] (WB, Human)	WB	Human
Laukka T, Mariani CJ, Ihantola T et al. Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes. J Biol Chem 2016-02-19 [PMID: 26703470]
Cavadas MA, Mesnieres M, Crifo B et al. REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia. Sci Rep. 2015-12-09 [PMID: 26647819] (WB, Human)	WB	Human
Gkotinakou I, Kechagia E, Pazaitou Panayiotou K et al. Regulation of Hypoxia Inducible Factors HIF-1 and HIF-2 by Calcidiol in Hepatocellular Carcinoma Cells Under Normoxia and Hypoxia SSRN Electronic Journal 2022-08-20 (WB, Human) Details: Dilution used for WB 1:800	WB	Human
Magliulo D, Caserta C, Belluschi S et al. The transcription factor HIF2alpha partakes in the differentiation block of acute myeloid leukemia Research Square 2022-06-15 (Chemotaxis, Human)	Chemotaxis	Human
Melanson G Computational analysis implicates interferon-stimulated gene 15 in hypoxic ribonucleoprotein dynamics Thesis 2021-01-01 (WB, Human)	WB	Human
Vukovic M, Guitart AV, Sepulveda C et al. Hif-1alpha and Hif-2alpha synergize to suppress AML development but are dispensable for disease maintenance. J. Exp. Med. 2015-12-14 [PMID: 26642852] (WB, Human)	WB	Human
Bhanu NV, Sidoli S, Garcia BA. Histone modification profiling reveals differential signatures associated with human embryonic stem cell self-renewal and differentiation. Proteomics. 2016-02-01 [PMID: 26631989]
Sun W, Kosyna FK, Jelkmann W, Depping R. Prolyl-4-Hydroxylase 2 Potentially Contributes to Hepatocellular Carcinoma-Associated Erythrocytosis by Maintaining Hepatocyte Nuclear Factor-4alpha Expression. Cell. Physiol. Biochem. 2015-12-24 [PMID: 26624507] (WB, Chemotaxis, Human)	WB, Chemotaxis	Human
Mandl M, Lieberum M, Dunst J, Depping R. The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment. Radiat Oncol. 2015-11-17 [PMID: 26572229] (WB, Human)	WB	Human
Cheng S, Xing W, Pourteymoor S et al. Conditional Deletion of Prolyl Hydroxylase Domain-containing Protein 2 (Phd2) Gene Reveals its Essential Role in Chondrocyte Function and Endochondral Bone Formation. Endocrinology. 2015-11-12 [PMID: 26562260] (WB, Mouse)	WB	Mouse
Aquino-Galvez A, Gonzalez-avila G. Effects of 2-methoxyestradiol on apoptosis and HIF-1a and HIF-2a expression in lung cancer cells under normoxia and hypoxia. ONCOLOGY REPORTS. 2015-08-20 [PMID: 26548300] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Highet AR, Khoda SM, Buckberry S et al. Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion. Eur. J. Cell Biol. 2015-12-01 [PMID: 26531845] (IHC-P, Human) Details: HIF2 alpha antibody was used for IHC-P on early / late first trimester and term uncomplicated control placentas. The IHC assay involved antigen retrieval through boiling the slides with citrate buffer pH 6.5 in microwave, blocking of endogenous peroxidase using 6% H2O2 for 1 hour, use of primary at 1:1500 dilution, and detection using biotinylated secondary, Streptavidin-HRP conjugate-DAB followed by counterstaining with haematoxylin (Fig. 5).	IHC-P	Human
Huh Yun Hyun, Lee Gyuseok, Lee Keun-Bae et al. HIF-2a-induced chemokines stimulate motility of fibroblast-like synoviocytes and chondrocytes into the cartilage-pannus interface in experimental rheumatoid arthritis mouse models. Arthritis Research & Therapy 2015-01-01 [PMID: 26510617] (IF/IHC, Mouse)	IF/IHC	Mouse
Zhang J, Wang C, Chen X et al. EglN2 associates with the NRF1-PGC1alpha complex and controls mitochondrial function in breast cancer. EMBO J 2015-12-02 [PMID: 26492917] (WB, Human)	WB	Human
Saini Y, Proper SP, Dornbos P et al. Loss of Hif-2alpha Rescues the Hif-1alpha Deletion Phenotype of Neonatal Respiratory Distress In Mice. PLoS One 2015-01-01 [PMID: 26422241] (IF/IHC, Mouse)	IF/IHC	Mouse
Stengel C, Newman SP, Leese MP et al. The in vitro and in vivo activity of the microtubule disruptor STX140 is mediated by Hif-1 alpha and CAIX expression Anticancer Res. 2016-03-31 [PMID: 26408684] (WB, Human)	WB	Human
Frey JL, Stonko DP, Faugere MC, Riddle RC Hypoxia-inducible factor-1alpha restricts the anabolic actions of parathyroid hormone. Bone Res 2014-05-13 [PMID: 26273518] (IP)	IP
Lu H Samanta D Xiang L et al. Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. Proc Natl Acad Sci U S A. 2015-07-30 [PMID: 26229077] (WB, Human)	WB	Human
Hogel H, Miikkulainen P, Bino L, Jaakkola PM. Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27. Mol. Cancer. 2015-07-30 [PMID: 26223520] (WB, Human) Details: PHD1 antibody used for WB on 786-O cell under hypoxia (1% O2) and normoxia (21 % O2) by siPHD1 (Figure 1C).	WB	Human
Ramakrishnan SK, Anderson ER, Martin A et al. Maternal intestinal HIF-2a is necessary for sensing iron demands of lactation in mice Proc. Natl. Acad. Sci. U.S.A. 2015-07-14 [PMID: 26124130] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Zhang X, Zhu J, Liu F et al. Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model. Bone Res 2014-08-05 [PMID: 26120493] (IF/IHC)	IF/IHC
Otto T, Gellhaus A, Luschen N et al. Oxygen Sensitivity of Placental Trophoblast Connexins 43 and 46: A Role in Preeclampsia? J Cell Biochem 2015-05-27 [PMID: 26018820]
Matsuyama T, Tanaka T, Tatsumi K et al. Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system. Eur. J. Pharmacol. 2015-05-19 [PMID: 26001375] (WB, Mouse)	WB	Mouse
Lin AE, Beasley FC, Olson J et al. Role of Hypoxia Inducible Factor-1alpha (HIF-1alpha) in Innate Defense against Uropathogenic Escherichia coli Infection. PLoS Pathog. 2015-04-01 [PMID: 25927232] (WB, Human)	WB	Human
Forristal CE, Brown AL, Helwani FM et al. Hypoxia inducible factor (HIF)-2alpha accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML. Leukemia. 2015-04-29 [PMID: 25921247] (WB, Mouse)	WB	Mouse
Koizume S, Ito S, Nakamura Y et al. Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer Mol. Cancer 2015-04-17 [PMID: 25879517] (IHC-P, ICC/IF, Human)	IHC-P, ICC/IF	Human
Shao J, Zhang Y, Yang T et al. HIF-1alpha disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression In Vitro Cell. Dev. Biol. Anim. 2015-04-10 [PMID: 25859979] (WB, Mouse)	WB	Mouse
Rad E, Dodd K, Thomas L et al. STAT3 and HIF1alpha Signaling Drives Oncogenic Cellular Phenotypes in Malignant Peripheral Nerve Sheath Tumors. Mol Cancer Res 2015-07-01 [PMID: 25833823] (Human)		Human
Wu S, Zhang J, Huang C et al. Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes. Curr Gene Ther 2015-01-01 [PMID: 25832622] (Mouse)		Mouse
McMurray F, Demetriades M, Aik W et al. Pharmacological Inhibition of FTO. PLoS One. 2015-04-01 [PMID: 25830347] (WB, Mouse)	WB	Mouse
Qiu B, Ackerman D, Sanchez DJ et al. HIF-2alpha dependent lipid storage promotes endoplasmic reticulum homeostasis in clear cell renal cell carcinoma Cancer Discov 2015-03-31 [PMID: 25829424] (WB, Human)	WB	Human
Shaw D, Wang X, Brown L et al. Infection-derived lipids elicit an immune deficiency circuit in arthropods. Nature Communications. [PMID: 25790189]
Zeng H, Vaka VR, He X et al. High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss. J. Cell. Mol. Med. 2015-03-17 [PMID: 25782072] (WB, Mouse)	WB	Mouse
Cotroneo E, Ashek A, Wang L et al. Iron Homeostasis and Pulmonary Hypertension: Iron Deficiency Leads to Pulmonary Vascular Remodeling in the Rat. Circ. Res. 2015-03-12 [PMID: 25767292] (WB, Rat)	WB	Rat
Doonachar A, Gallo MD, Doukas D et al. Differential effects of HIF-alpha isoforms on apoptosis in renal carcinoma cell lines Cancer Cell Int. 2015-03-02 [PMID: 25729330] (WB, Human)	WB	Human
Jimenez K, Khare V, Evstatiev R et al. Increased expression of HIF2alpha during iron deficiency-associated megakaryocytic differentiation J. Thromb. Haemost. 2015-02-25 [PMID: 25715026] (IHC-P, Rat)	IHC-P	Rat
Matak P, Heinis M, Mathieu JR et al. Myeloid HIF-1 Is Protective in Helicobacter pylori-Mediated Gastritis J. Immunol. 2015-02-20 [PMID: 25710915] (IHC-P, Human)	IHC-P	Human
Chen Rui, Xu Min, Nagati Jason S et al. The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment. PLoS One. 2014-01-01 [PMID: 25689462]
Nozawa-Suzuki N, Nagasawa H, Ohnishi K, Morishige KI. The inhibitory effect of hypoxic cytotoxin on the expansion of cancer stem cells in ovarian cancer Biochem. Biophys. Res. Commun. 2015-01-22 [PMID: 25619133] (WB, Human)	WB	Human
Neelam S, Brooks MM, Cammarata PR. Lenticular cytoprotection, part 2: Link between glycogen synthase kinase-3b, epithelial to mesenchymal transition, and mitochondrial depolarization. Molecular Vision. 2014-01-01 [PMID: 25593505] (WB, Human) Details: HIF-2 alpha/EPAS1 antibody used for WB on lysates of HLE-B3 cells, a human lens epithelial cell line immortalized by the SV-40 virus, treated or not with HIF-2 alpha translation inhibitor (CAS882268-69-1) at 0.5, 5 and 50 uM concentrations (Figure 11A)	WB	Human
Xiang L, Gilkes DM, Hu H et al. Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. Oncotarget. 2014-01-01 [PMID: 25587023] (WB, IP, Chemotaxis, Human)	WB, IP, Chemotaxis	Human
Gong H, Rehman J, Tang H et al. HIF2alpha signaling inhibits adherens junctional disruption in acute lung injury. J Clin Invest 2015-02-01 [PMID: 25574837]
Yoo S, Takikawa S, Geraghty P et al. Integrative Analysis of DNA Methylation and Gene Expression Data Identifies EPAS1 as a Key Regulator of COPD PLoS Genet. 2015-01-01 [PMID: 25569234] (WB, Human) Details: HIF-2 alpha/EPAS1 antibody used for IHC-P on human lung tissues from Chronic Obstructive Pulmonary Disease/COPD and non-COPD patients - antigen retrieval with 10 mM citrate buffer, endogenous peroxidase blocked with 0.3% H2O2-methanol , blocked with 5% goat serum diluted in PBS containing 0.1% Tween-20 for 30 minutes, primary antibody used at 1:100 dilution with 1 hour RT incubation, detection with anti-rabbit-HRP secondary and Vectastain ABC Elite Kit. HIF-2 alpha/EPAS1 protein levels were found to be lower in the lung tissues of COPD patients compared to control subjects.	WB	Human
Tsuboi I, Yamashita T, Nagano M et al. Impaired expression of HIF -2alpha induces compensatory expression of HIF-1alpha for the recovery from anemia J. Cell. Physiol. 2015-01-03 [PMID: 25557133] (WB, Chemotaxis, Mouse)	WB, Chemotaxis	Mouse
Cannito S, Turato C, Paternostro C et al. Hypoxia up-regulates SERPINB3 through HIF-2alpha in human liver cancer cells. Oncotarget. 2015-02-10 [PMID: 25544768] (Chemotaxis, Human)	Chemotaxis	Human
D C Singleton, P Rouhi, C E Zois et al. Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis. Oncogene 2014-12-08 [PMID: 25486436] (WB, Human)	WB	Human
Samanta D, Gilkes D, Chaturvedi P, Xiang L, Semenza G. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proc Natl Acad Sci U S A. 2014-12-01 [PMID: 25453096] (WB, Human)	WB	Human
Koh MY, Nguyen V, Lemos R et al. Hypoxia-Induced SUMOylation of E3 Ligase HAF Determines Specific Activation of HIF2 in Clear-Cell Renal Cell Carcinoma. Cancer Res. 2014-11-24 [PMID: 25421578] (WB, Human) Details: HIF-2 alpha/EPAS1 antibody used for WB, ChIP, ICC-IF and IHC-P in experiments involving A498, 786-O, PANC-1, MIAPaCa-2, and ACHN cell lines and tumor microarray /TMAs comprising pretreatment nephrectomy specimens of patients with metastatic grade 3/4 CRCC treated with sorafenib or sorafenib plus interferon.	WB	Human
Henze At, Garvalov Bk, Seidel S et al. Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR. Nat Commun. 2014-11-25 [PMID: 25420773]
Hou P, Kuo Cy, Cheng Ct et al. Intermediary Metabolite Precursor Dimethyl-2-Ketoglutarate Stabilizes Hypoxia-Inducible Factor-1Alpha by Inhibiting Prolyl-4-Hydroxylase PHD2. PLoS OnE. 2014-11-25 [PMID: 25420025] (WB, Human)	WB	Human
Qi Y, Liu J, Saadat S et al. PTEn induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation. Cell Death Differ. 2014-11-14 [PMID: 25394489] (WB, Mouse)	WB	Mouse
Chen Sj, Hoffman Ne, Shanmughapriya S et al. A Splice Variant of the Human Ion Channel TRPM2 Modulates neuroblastoma Tumor Growth Through HIF-1/2Alpha. J. Biol. Chem. 2014-11-12 [PMID: 25391657] (WB, Human)	WB	Human
Assar Me, Sanchez-Puelles Jm, Royo I et al. FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/enOS pathway, independently of mTOR/HIF-1Alpha activation Br. J. Pharmacol. 2014-11-03 [PMID: 25363469] (WB, Rat) Details: HIF-1 alpha antibody used for WB on lysates of ex vivo FM19G11 treated aortic and mesenteric arteries from control and insulin-resistant rats (Figure 6).	WB	Rat
Su Ej, Xin H, Yin P et al. Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery Doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARnT). J. Clin. Endocrinol. Metab. 2014-10-24 [PMID: 25343232] (WB, Human)	WB	Human
Wu R, Chang Hc, Khechaduri A et al. Cardiac-specific ablation of ARnT leads to lipotoxicity and cardiomyopathy. J. Clin. Invest. 2014-11-03 [PMID: 25329697] (Chemotaxis, Human)	Chemotaxis	Human
Hu H, Takano N, Xiang L et al. Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget 2014-10-15 [PMID: 25326682] (Chemotaxis, WB, Human)	Chemotaxis, WB	Human
Zhou Y, Yuge A, Rajah Am et al. LIMK1 Regulates Human Trophoblast Invasion/Differentiation and Is Down-Regulated in Preeclampsia. Am. J. Pathol. 2014-10-09 [PMID: 25307528] (IF/IHC, Human)	IF/IHC	Human
Nagaya Y, Aoyama M, Tamura T et al. Inflammatory cytokine tumor necrosis factor Alpha suppresses neuroprotective endogenous erythropoietin from astrocytes mediated by hypoxia-inducible factor-2Alpha. Eur. J. neurosci. 2014-10-04 [PMID: 25283246] (WB)	WB
Petruzzelli R, Christensen DR, Parry KL et al. HIF-2a Regulates NANOG Expression in Human Embryonic Stem Cells following Hypoxia and Reoxygenation through the Interaction with an Oct-Sox Cis Regulatory Element. PLoS ONE. 2014-10-02 [PMID: 25271810] (ICC/IF, Chemotaxis, Human) Details: HIF-2 alpha/EPAS1 antibody used for ChIP and ICC-IF in experiments involving human embryonic stem cell /hESC.	ICC/IF, Chemotaxis	Human
Bordji K, Grandval A, Cuhna-Alves L et al. Hypoxia-inducible factor-2a (HIF-2a), but not HIF-1a, is essential for hypoxic induction of class III b-tubulin expression in human glioblastoma cells. FEBS J. 2014-09-22 [PMID: 25244496] (WB, GS, Human) Details: HIF-2 alpha/EPAS1 antibody used for WB and EMSA/Gel Super Shift Assay in experiments involving human glioblastoma cell lines - U87MG (p53 wild-type, PTEN mutant) , U251MG (p53 mutant, PTEN mutant) and GL15 (obtained from a frontal lobe tumor biopsy of a 59-year-old man with GBM).	WB, GS	Human
Muz B, de la Puente P, Azab F et al. Hypoxia Promotes Dissemination and Colonization in New Bone Marrow Niches in Waldenstrom's Macroglobulinemia. Mol. Cancer Res. 2014-09-17 [PMID: 25232031] (WB, Mouse)	WB	Mouse
Lalevee S, Lapaire O, Buhler M. miR455 is linked to hypoxia signaling and is deregulated in preeclampsia. Cell Death Dis. 2014-09-04 [PMID: 25188518]
Fujikuni N, Yamamoto H, Tanabe K et al. Hypoxia-mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion. Cancer Sci 2014-11-01 [PMID: 25174257] (WB)	WB
Asnaghi L, Lin MH, Lim KS et al. Hypoxia Promotes Uveal Melanoma Invasion through Enhanced Notch and MAPK Activation. PLoS ONE. 2014-08-28 [PMID: 25166211] (WB, Human)	WB	Human
Yoshizawa Sayuri, Brown Andrew, Barchowsky Aaron, Sfeir Charles. Role of magnesium ions on osteogenic response in bone marrow stromal cells. Connect Tissue Res. 2014-08-01 [PMID: 25158202]
Hubbi ME, Gilkes DM, Hu H et al. Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1alpha to promote cell-cycle progression. Proc Natl Acad Sci U S A. 2014-07-28 [PMID: 25071185] (WB, Human)	WB	Human
Kurt B, Gerl K, Karger C et al. Chronic Hypoxia-Inducible Transcription Factor-2 Activation Stably Transforms Juxtaglomerular Renin Cells into Fibroblast-Like Cells In Vivo J Am Soc Nephrol. 2014-07-27 [PMID: 25071089] (IF/IHC, Mouse)	IF/IHC	Mouse
Li B, Qiu B, Lee DS et al. Fructose-1, 6-bisphosphatase opposes renal carcinoma progression. Nature 2014-09-11 [PMID: 25043030] (IP, WB, Human)	IP, WB	Human
MEsange P, Poindessous V, Sabbah M et al. Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor Oncotarget. 2014-01-19 [PMID: 25015210] (IF/IHC, WB, Mouse)	IF/IHC, WB	Mouse
Wong WJ, Richardson T, Seykora JT et al. Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function. J Invest Dermatol 2015-02-01 [PMID: 24999590] (WB)	WB
Liu XD, Yao J, Tripathi DN et al. Autophagy mediates HIF2a degradation and suppresses renal tumorigenesis. Oncogene 2014-07-07 [PMID: 24998849] (WB, CoIP, IP, Human) Details: HIF-2 alpha antibody used for WB, IP and CoIP in several experiments involving Caki-I cells, RPE cells, HEK293T stable cell line expressing HIF2a-GFP, 786-O parental cells/ and its over-expression derivatives, and Atg5+/+ or Atg5- / - MEFs stably expressing HIF2a-GFP.	WB, CoIP, IP	Human
Slominski A, Kim TK, Brozyna AA et al. The role of melanogenesis in regulation of melanoma behavior: Melanogenesis leads to stimulation of HIF-1a expression and HIF-dependent attendant pathways. Arch. Biochem. Biophys. 2014-07-02 [PMID: 24997364] (WB, Hamster, Human) Details: HIF-1 alpha antibody used for WB on whole cell lysates of Bomirski hamster AbC1 and human SKMEL-188 stable lined (amelanotic /non-pigmented and melanotic /pigmented lines) with Hif1a wild type/WT and knockout /KO mammary tumor epithelial cells (MTECs) derived from the polyoma virus middle T transgenic mouse (MMTV-PyMT) as positive control for HIF-1 alpha. Antibody used at 1:5000 dilution and the data is shown in Fig 1.	WB	Hamster, Human
Kono K, Tamashiro DA, Alarcon VB. Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of hippo signaling in the mouse blastocyst. Dev. Biol. 2014-07-02 [PMID: 24997360] (WB, Human, Hamster) Details: HIF-2 alpha antibody used for WB on lysates of Bomirski hamster AbC1 and human SKMEL-188 cell lines (Fig. 1).	WB	Human, Hamster
Takano N, Sarfraz Y, Gilkes DM et al. Decreased Expression of Cystathionine b-Synthase Promotes Glioma Tumorigenesis. Mol Cancer Res. 2014-07-03 [PMID: 24994751] (WB, Human)	WB	Human
Mangiavini L, Merceron C, Araldi E et al. Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development Dev. Biol. 2014-06-24 [PMID: 24972088] (IHC-P, Mouse) Details: HIF-1 alpha antibody used for Western blot at 1:1000 dilution in protein lysate from chondrocytes of CNTRL and VHL mice ( protocol details provided in this article, WB image - Supplemental Fig. 1, Panel B)	IHC-P	Mouse
Rana S, Rajakumar A, Geahchan C et al. Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1alpha pathway. FASEB J. 2014-06-26 [PMID: 24970393] (WB, Human) Details: Used for WB on HIF-2 expression in both normal and pre-eclamptic placental villous explant cultures treated with 500 nM ouabain(Fig. 3F, G).	WB	Human
Furcht CM, Buonato JM, Skuli N et al. Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells. J. Cell. Sci. 2014-06-20 [PMID: 24951116] (WB, Human) Details: Antibody used for detecting HIF2 alpha by WB in U87MG-M 281 control or SHP2 knockdown cells generated ectopic xenograft tumors in Nu/Nu mice (Fig. 6C, 6D)	WB	Human
Salman Shaima, Holloway Alison C, Nurse Colin A. Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2alpha and protein kinase A. Am J Physiol Cell Physiol. 2014-08-01 [PMID: 24898587] (Rat)		Rat
Arreola A, Cowey CL, Coloff JL et al. HIF1alpha and HIF2alpha Exert Distinct Nutrient Preferences in Renal Cells. PLoS ONE. 2014-06-02 [PMID: 24879016] (ICC/IF, Mouse)	ICC/IF	Mouse
Rawluszko-Wieczorek A A, Horbacka K et al. Prognostic potential of DNA methylation and transcript levels of HIF1A and EPAS1 in colorectal cancer. Mol Cancer Res 2014-01-08 [PMID: 24825851] (WB, Human)	WB	Human
Chaturvedi P, Gilkes DM, Takano N, Semenza GL. Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment. Proc Natl Acad Sci U S A. [PMID: 24799675] (Chemotaxis, Human) Details: Citation using the FITC form of this antibody.	Chemotaxis	Human
Ding Z, German P, Bai S et al. Genetic and Pharmacological Strategies to Refunctionalize the von Hippel Lindau R167Q Mutant Protein. Cancer Research 2014-03-13 [PMID: 24755468] (WB, Human)	WB	Human
Gerovac BJ, Valencia M, Baumlin N et al. Submersion and Hypoxia Inhibit Ciliated Cell Differentiation in a Notch Dependent Manner.. Am. J. Respir. Cell Mol. Biol. [PMID: 24754775]
Pang M, Liu X, Slagle-Webb B. Role of H-Ferritin in Radiosensitivity of Human Glioma Cells. HSOA Journal of Cancer Biology and Treatment 2016-01-21 [PMID: 24707546] (WB, Human)	WB	Human
Kihira Yoshitaka, Miyake Mariko, HiRata Manami et al. Deletion of hypoxia-inducible factor-1a in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation. PloS One 2014-01-01 [PMID: 24705496] (WB, Mouse)	WB	Mouse
Qin N, de Cubas AA, Garcia-Martin R et al. Opposing effects of HIF1a and HIF2a on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MAX. Int. J. Cancer 2014-03-27 [PMID: 24676840] (WB, IHC-P, Human, Mouse)	WB, IHC-P	Human, Mouse
Heyboer M, Milovanova TN, Wojcik S et al. CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen - Changes with oxygen dosage. Stem Cell Res 2014-03-19 [PMID: 24642336] (FLOW, Human)	FLOW	Human
Zhang J, Ma WY. Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway. Genet. Mol. Res. 2014-01-24 [PMID: 24615084] (WB, Human)	WB	Human
Huang YH, Lin MH, Wang PC et al. Hypoxia inducible factor 2a/insulin-like growth factor receptor signal loop supports the proliferation and Oct-4 maintenance of mouse germline stem cells. Mol. Hum. Reprod. 2014-03-23 [PMID: 24598112] (ICC/IF, WB, Mouse)	ICC/IF, WB	Mouse
Lian G, Wei C, Wang D et al. Protein Profiling of H. pylori-Associated Gastric Cancer. Am. J. Pathol. 2014-02-28 [PMID: 24589339] (WB, Human)	WB	Human
Fiorito Veronica, Neri Francesco, Pala Valentina et al. Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2alpha and ETS1. Biochim Biophys Acta. 2014-02-24 [PMID: 24576667]
Yoshizawa S, Brown A, Barchowsky A. Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation. Acta Biomater 2014-02-24 [PMID: 24512978] (WB, Human)	WB	Human
Duan LJ, Takeda K, Fong GH. Hematological, Hepatic, and Retinal Phenotypes in Mice Deficient for Prolyl Hydroxylase Domain (PHD) Proteins in the Liver. Am. J. Pathol. 2014-02-19 [PMID: 24508125] (WB, Mouse)	WB	Mouse
Wojciak-Stothard B, Abdul-Salam Vb, Lao Kh et al. Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension Circulation et al. 2014-04-29 [PMID: 24503951] (WB, Mouse) Details: HIF2 alpha antibody used for WB on lysates from lungs of wildtype (WT) and CLIC4 KO mice subjected to normoxic and hypoxic conditions.	WB	Mouse
Weisel FC, Kloepping C, Pichl A et al. Impact of S-Adenosylmethionine Decarboxylase 1 in Pulmonary Vascular Remodeling. Circulation 2014-01-28 [PMID: 24470481] (Chemotaxis, Human, Mouse)	Chemotaxis	Human, Mouse
Chen Z, Liu X, Mei Z, Xiao W. EAF2 Suppresses Hypoxia-Induced Factor 1 alpha Transcriptional Activity by Disrupting Its Interaction with Coactivator CBP/p300. Mol. Cell. Biol. 2014-03-01 [PMID: 24421387] (WB, Human)	WB	Human
Kumar V, Everingham S, Hall C et al. Calpains promote neutrophil recruitment and bacterial clearance in an acute bacterial peritonitis model. Eur J Immunol 2013-12-05 [PMID: 24375267] (WB, Mouse)	WB	Mouse
Place TL, Nauseef JT, Peterson MK et al. Prolyl-4-Hydroxylase 3 (PHD3) Expression Is Downregulated during Epithelial-to-Mesenchymal Transition. PLoS One 2013-12-18 [PMID: 24367580] (WB, Human)	WB	Human
Gomes AP, Price NL, Ling AJ et al. Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging. Cell 2013-12-19 [PMID: 24360282] (WB, Mouse)	WB	Mouse
Pasupuleti V, Du W, Gupta Y et al. Dysregulated D-Dopachrome Tautomerase, a Hypoxia Inducible Factor-Dependent Gene, Cooperates with Macrophage Migration Inhibitory Factor in Renal Tumorigenesis. J Biol Chem 2013-12-19 [PMID: 24356968] (Chemotaxis, WB, Human)	Chemotaxis, WB	Human
Zhu J, Jiang X, Chehab FF. FoxO4 Interacts with the Sterol Regulatory Factor SREBP2 and the Hypoxia Inducible Factor HIF2A at the CYP51 Promoter. J Lipid Res 2013-12-18 [PMID: 24353279] (Chemotaxis, WB, Mouse)	Chemotaxis, WB	Mouse
Razorenova OV, Castellini L, Colavitti R et al. The Apoptosis Repressor with a CARD Domain (ARC) Gene Is a Direct Hypoxia-Inducible Factor 1 Target Gene and Promotes Survival and Proliferation of VHL-Deficient Renal Cancer Cells. Mol Cell Biol 2014-02-01 [PMID: 24344197] (WB, Human)	WB	Human
Takano N, Peng YJ, Kumar GK et al. Hypoxia-inducible factors regulate human and rat cystathionine b-synthase gene expression. Biochem J. 2013-12-12 [PMID: 24328859] (WB, Chemotaxis, Rat, Human)	WB, Chemotaxis	Rat, Human
Bocca C, Ievolella M, Autelli R et al. Expression of Cox-2 in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasiveness. Expert Opin Ther Targets 2014-02-01 [PMID: 24325753] (IHC-P, Human)	IHC-P	Human
Chen Z, He X, Xia W et al. Prognostic Value and Clinicopathological Differences of HIFs in Colorectal Cancer: Evidence from Meta-Analysis. PLoS One 2013-12-06 [PMID: 24324596] (IF/IHC, Human)	IF/IHC	Human
Gilkes DM, Xiang L, Lee SJ et al. Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells. Proc Natl Acad Sci U S A 2014-01-21 [PMID: 24324133] (Chemotaxis, WB, Human)	Chemotaxis, WB	Human
Chiatar SS, Eze OP, Schoenfeld AR. Expression of VHL Causes Three-Dimensional Morphological Changes in Renal Cells Indicative of Proximal Tubule Differentiation Cell Dev Biol. 2013-08-12 [PMID: 24308012] (WB, Human)	WB	Human
Glover LE, Bowers BE, Saeedi B et al. Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis. Proc Natl Acad Sci U S A 2013-12-03 [PMID: 24248342] (WB, Chemotaxis, Human)	WB, Chemotaxis	Human
Xiang L, Gilkes DM, Chaturvedi P et al. Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer. J Mol Med (Berl). 2013-11-20 [PMID: 24248265]
Proper SP, Saini Y, Greenwood KK et al. Loss of hypoxia-inducible factor 2 alpha (HIF2alpha) in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury. Toxicol Sci. 2013-11-11 [PMID: 24218148] (IHC-P, Mouse)	IHC-P	Mouse
Xu Z, Zhao L, Zhu LY et al. MicroRNA-17, 20a Regulates the Proangiogenic Function of Tumor-Associated Macrophages via Targeting Hypoxia-Inducible Factor 2alpha. PLoS One. 2013-10-23 [PMID: 24194900] (IHC-Fr, IHC-P, ICC/IF, WB, Human)	IHC-Fr, IHC-P, ICC/IF, WB	Human
Poitz DM, Augstein A, Hesse K et al. Regulation of the HIF-system in Human macrophages - Differential regulation of HIF-alpha subunits under sustained hypoxia. Mol Immunol. 2013-10-28 [PMID: 24176785] (WB, Human)	WB	Human
Scholz CC, Cavadas MA, Tambuwala MM et al. Regulation of IL-1beta-induced NF-kB by hydroxylases links key hypoxic and inflammatory signaling pathways. Proc Natl Acad Sci U S A. 2013-11-12 [PMID: 24145445] (WB, Human)	WB	Human
Selvarajah J, Nathawat K, Moumen A et al. Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways. Cell Death Dis. 2013-10-17 [PMID: 24136229] (WB, Human)	WB	Human
Nanduri J, Vaddi DR, Khan SA et al. Xanthine oxidase mediates hypoxia-inducible factor-2alpha degradation by intermittent hypoxia. PLoS One. 2013-10-04 [PMID: 24124516] (WB, Rat)	WB	Rat
Cowburn AS, Takeda N, Boutin AT et al. HIF isoforms in the skin differentially regulate systemic arterial pressure. Proc Natl Acad Sci U S A. 2013-10-22 [PMID: 24101470] (IHC-P, WB, Mouse)	IHC-P, WB	Mouse
Eckle T, Brodsky K, Bonney M et al. HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium. PLoS Biol. 2013-09-01 [PMID: 24086109] (WB, Human)	WB	Human
Doedens AL, Phan AT, Stradner MH et al. Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen. Nat Immunol. 2013-11-01 [PMID: 24076634] (WB, Mouse)	WB	Mouse
Cowburn AS, Alexander LE, Southwood M et al. Epidermal Deletion of HIF-2alpha Stimulates Wound Closure. J Invest Dermatol. 2013-09-13 [PMID: 24037341] (WB, Human)	WB	Human
Wei K, Piecewicz SM, McGinnis LM et al. A liver Hif-2alpha-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nat Med. 2013-10-01 [PMID: 24037094] (WB, Mouse)	WB	Mouse
Pawlus MR, Wang L, Murakami A. STAT3 or USF2 Contributes to HIF Target Gene Specificity. PLoS One 2013-08-21 [PMID: 23991099] (WB, Chemotaxis, Human) Details: Using the Biotin conjugated version of NB100-134, catalog number NB100-134B.	WB, Chemotaxis	Human
Luo X, Hill M, Johnson A, Latunde-Dada GO. Modulation of Dcytb (Cybrd 1) expression and function by iron, dehydroascorbate and Hif-2alpha in cultured cells. Biochim Biophys Acta. 2013-08-24 [PMID: 23981688] (WB, Human)	WB	Human
Befani C, Mylonis I, Gkotinakou IM et al. Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells. Int J Biochem Cell Biol. 2013-08-16 [PMID: 23958427] (WB, Human)	WB	Human
Hanna C, Hubchak SC, Liang X et al. Hypoxia-inducible factor-2alpha and TGF-beta signaling interact to promote normoxic glomerular fibrogenesis. Am J Physiol Renal Physiol. 2013-11-01 [PMID: 23946285] (WB, Human)	WB	Human
Regan Anderson TM, Peacock DL, Daniel AR et al. Breast Tumor Kinase (Brk/PTK6) Is a Mediator of Hypoxia-Associated Breast Cancer Progression. Cancer Res. 2013-09-15 [PMID: 23928995] (WB, Human)	WB	Human
Brackmann FA, Link AS, Jung S et al. Activin A regulation under global hypoxia in developing mouse brain. Brain Res 2013-07-31 [PMID: 23916668] (WB, Mouse)	WB	Mouse
Poitz DM, Augstein A, Gradehand C et al. Regulation of the Hif-system by micro-RNA 17 and 20a - Role during monocyte-to-macrophage differentiation. Mol Immunol 2013-07-31 [PMID: 23911400] (WB, Human)	WB	Human
You Q, Holt M, Yin H et al. Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem Pharmacol 2013-07-19 [PMID: 23876342] (WB, Mouse)	WB	Mouse
Kim M, Park HJ, Seol JW et al. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. EMBO Mol Med 2013-07-12 [PMID: 23853117] (IHC-P, Mouse)	IHC-P	Mouse
Wong WJ, Qiu B, Nakazawa MS et al. MYC Degradation Under Low O2 Tension Promotes Survival by Evading Hypoxia-Induced Cell Death. Mol Cell Biol 2013-07-01 [PMID: 23816886] (WB, Human)	WB	Human
Xie L, Collins JF. Transcription Factors Sp1 and Hif2alpha Mediate Induction of the Copper-Transporting ATPase (Atp7a) Gene in Intestinal Epithelial Cells During Hypoxia. J Biol Chem 2013-06-28 [PMID: 23814049] (WB, Chemotaxis, Rat)	WB, Chemotaxis	Rat
Sato Y, Yoshizato T, Shiraishi Y et al. Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet 2013-06-24 [PMID: 23797736] (IF/IHC, Human)	IF/IHC	Human
Goetze O, Schmitt J, Spliethoff K et al. Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers. Hepatology. 2013-06-20 [PMID: 23787477] (IHC-Fr, ICC/IF, Human)	IHC-Fr, ICC/IF	Human
Ikeda J, Ichiki T, Matsuura H et al. Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling. J Am Heart Assoc 2013-06-18 [PMID: 23778187] (WB, Human)	WB	Human
Wilkinson N, Pantopoulos K. IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2a mRNA translation. Blood. 2013-08-29 [PMID: 23777768] (WB, Mouse)	WB	Mouse
Kerkela R, Karsikas S, Szabo Z et al. Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection. Mol Cell Biol. 2013-08-01 [PMID: 23775121] (WB, Mouse)	WB	Mouse
Hubbi ME, Hu H, Kshitiz et al. Sirtuin-7 Inhibits the Activity of Hypoxia-Inducible Factors. J Biol Chem 2013-07-19 [PMID: 23750001] (WB, Human)	WB	Human
Forristal CE, Christensen DR, Chinnery FE et al. Environmental Oxygen Tension Regulates the Energy Metabolism and Self-Renewal of Human Embryonic Stem Cells. Plos One 2013-05-06 [PMID: 23671606] (Chemotaxis, Human)	Chemotaxis	Human
Thapa RJ, Chen P, Cheung M et al. NF-kB Inhibition by Bortezomib Permits IFN-y-Activated RIP1 Kinase-Dependent Necrosis in Renal Cell Carcinoma. Mol Cancer Ther. 2013-08-01 [PMID: 23657944] (WB, Human)	WB	Human
Mao XG, Xue XY, Wang L et al. CDH5 is specifically activated in glioblastoma stemlike cells and contributes to vasculogenic mimicry induced by hypoxia. Neuro Oncol 2013-05-03 [PMID: 23645533] (Chemotaxis, WB, Human)	Chemotaxis, WB	Human
Pawlus MR, Wang L, Hu CJ. STAT3 and HIF1alpha cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Oncogene 2013-04-22 [PMID: 23604114] (WB, Human)	WB	Human
Luo B, Jiang M, Yang X et al. Erythropoietin is a hypoxia inducible factor-induced protective molecule in experimental autoimmune neuritis Biochim Biophys Acta 2013-04-23 [PMID: 23603807] (WB, Rat)	WB	Rat
Matak P, Zumerle S, Mastrogiannaki M et al. Copper Deficiency Leads to Anemia, Duodenal Hypoxia, Upregulation of HIF-2alpha and Altered Expression of Iron Absorption Genes in Mice PLoS One 2013-01-01 [PMID: 23555700] (WB, Mouse)	WB	Mouse
Gilkes DM, Chaturvedi P, Bajpai S et al. Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Res 2013-06-01 [PMID: 23539444] (WB, Human)	WB	Human
Mohlin S, Hamidian A, Pahlman S. HIF2A and IGF2 Expression Correlates in Human Neuroblastoma Cells and Normal Immature Sympathetic Neuroblasts Neoplasia 2013-03-01 [PMID: 23479510] (IHC-P, Human)	IHC-P	Human
Parks SK, Mazure NM, Counillon L, Pouyssegur J. Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels J Cell Physiol 2013-03-04 [PMID: 23459996] (WB, Human)	WB	Human
Gonzalez-Flores A, Aguilar-Quesada R, Siles E et al. Interaction between PARP-1 and HIF-2alpha in the hypoxic response. Oncogene 2013-03-04 [PMID: 23455322] (WB, IP, Mouse, Human)	WB, IP	Mouse, Human
Fu L, Wang G, Shevchuk MM et al. Activation of HIF2alpha in Kidney Proximal Tubule Cells Causes Abnormal Glycogen Deposition but not Tumorigenesis. Cancer Res 2013-05-01 [PMID: 23447580] (IF/IHC, Mouse)	IF/IHC	Mouse
Maruyama T, Miyamoto Y, Yamamoto G et al. Downregulation of Carbonic Anhydrase IX Promotes Col10a1 Expression in Chondrocytes. PLoS One 2013-01-01 [PMID: 23441228] (WB, Mouse)	WB	Mouse
Choi HJ, Sanders TA, Tormos KV et al. ECM-Dependent HIF Induction Directs Trophoblast Stem Cell Fate via LIMK1-Mediated Cytoskeletal Rearrangement. PLoS One 2013-01-01 [PMID: 23437279] (WB, Mouse)	WB	Mouse
Finger EC, Cheng CF, Williams TR et al. CTGF is a therapeutic target for metastatic melanoma. Oncogene 2013-02-25 [PMID: 23435419] (WB, Human)	WB	Human
Gilkes DM, Bajpai S, Chaturvedi P et al. HIF-1 Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by Inducing P4HA1, P4HA2, and PLOD2 Expression in Fibroblasts. J Biol Chem 2013-02-19 [PMID: 23423382] (WB, Human)	WB	Human
Emerling BM, Benes CH, Poulogiannis G et al. Identification of CDCP1 as a hypoxia-inducible factor 2alpha (HIF-2alpha) target gene that is associated with survival in clear cell renal cell carcinoma patients. Proc Natl Acad Sci U S A 2013-02-26 [PMID: 23378636] (Chemotaxis, Human)	Chemotaxis	Human
Gilkes DM, Bajpai S, Wong CC et al. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Mol Cancer Res 2013-05-01 [PMID: 23378577] (WB, Human)	WB	Human
Storti P, Bolzoni M, Donofrio G et al. Hypoxia-inducible factor (HIF)-1alpha suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction. Leukemia 2013-01-24 [PMID: 23344526] (WB, Human)	WB	Human
Neelam S, Brooks MM, Cammarata PR. The role of hypoxia inducible factors-1alpha and -2alpha and vascular endothelial growth factor in lens epithelial cell survival in hypoxia. Mol Vis. 2013-01-01 [PMID: 23335846] (WB, Human)	WB	Human
Pang Y, Xu Y, Li H et al. The inhibition of HIF-2alpha on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation. Toxicol Lett 2013-01-17 [PMID: 23333640] (WB, Human)	WB	Human
Zhang Y, Wang H, Zhang J et al. Positive feedback loop and synergistic effects between hypoxia-inducible factor-2alpha and stearoyl-CoA desaturase-1 promote tumorigenesis in clear cell renal cell carcinoma Cancer Sci 2013-04-01 [PMID: 23331615] (WB, IHC-P, Human)	WB, IHC-P	Human
Shimanishi M, Ogi K, Sogabe Y et al. Silencing of GLUT-1 inhibits sensitization of oral cancer cells to cisplatin during hypoxia J Oral Pathol Med 2012-12-10 [PMID: 23227892] (WB, Human)	WB	Human
Vanharanta S, Shu W, Brenet F et al. Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer Nat Med 2012-12-09 [PMID: 23223005] (WB, Mouse)	WB	Mouse
Xu Y, Li Y, Li H, et al. The accumulations of HIF-1alpha and HIF-2alpha by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells Toxicol Appl Pharmacol 2012-11-27 [PMID: 23194660] (WB, Human)	WB	Human
Salnikov AV, Liu L, Platen M et al. Hypoxia Induces EMT in Low and Highly Aggressive Pancreatic Tumor Cells but Only Cells with Cancer Stem Cell Characteristics Acquire Pronounced Migratory Potential PLoS One 2012-01-01 [PMID: 23050024] (IF/IHC, ICC/IF, Human)	IF/IHC, ICC/IF	Human
Croci DO, Salatino M, Rubinstein N et al. Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma J Exp Med 2012-10-22 [PMID: 23027923] (WB, Human)	WB	Human
Casagrande S, Ruf M, Rechsteiner M et al. The protein tyrosine phosphatase receptor type J is regulated by the pVHL-HIF axis in clear cell renal cell carcinoma. J Pathol 2012-09-24 [PMID: 23007793] (WB, Human)	WB	Human
Pawlus MR, Wang L, Ware K, Hu CJ. USF2 and HIF2alpha cooperatively activate HIF2 target genes during hypoxia Mol Cell Biol 2012-09-10 [PMID: 22966206] (WB, Chemotaxis, Human)	WB, Chemotaxis	Human
Park SJ, Lee KS, Lee SJ et al. L-2-Oxothiazolidine-4-Carboxylic Acid or alpha-Lipoic Acid Attenuates Airway Remodeling: Involvement of Nuclear Factor-kB (NF-kB), Nuclear Factor Erythroid 2p45-Related Factor-2 (Nrf2), and Hypoxia-Inducible Factor (HIF) Int J Mol Sci 2012-01-01 [PMID: 22942681] (WB, Mouse)	WB	Mouse
Krishnamachary B, Penet MF, Nimmagadda S et al. Hypoxia Regulates CD44 and Its Variant Isoforms through HIF-1alpha in Triple Negative Breast Cancer PLoS One 2012-01-01 [PMID: 22937154] (WB, Human)	WB	Human
Yamasaki T, Kamba T, Kanno T et al. Tumor microvasculature with endothelial fenestrations in VHL null clear cell renal cell carcinomas as a potent target of anti-angiogenic therapy Cancer Sci 2012-11-01 [PMID: 22931246] (WB, Human)	WB	Human
Chiabrando D, Fiorito V, Marro S et al. Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice. Blood Cells Mol Dis 2013-01-01 [PMID: 22921471]
Sciorra VA, Sanchez MA, Kunibe A, Wurmser AE. Suppression of glioma progression by egln3 PLoS One 2012-01-01 [PMID: 22905089] (WB, Human, Rat)	WB	Human, Rat
Chiavarina B, Martinez-Outschoorn UE, Whitaker-Menezes D et al. Metabolic reprogramming and two-compartment tumor metabolism: Opposing role(s) of HIF1alpha and HIF2alpha in tumor-associated fibroblasts and human breast cancer cells Cell Cycle 2012-09-01 [PMID: 22894905] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Anderson ER, Taylor M, Xue X et al. The Hypoxia-Inducible Factor-C/EBPalpha Axis Controls Ethanol-Mediated Hepcidin Repression Mol Cell Biol 2012-10-01 [PMID: 22869521] (WB, Mouse)	WB	Mouse
Nayak BK, Feliers D, Sudarshan S et al. Stabilization of HIF-2 alpha through redox regulation of mTORC2 activation and initiation of mRNA translation Oncogene 2012-08-06 [PMID: 22869144] (WB, Human)	WB	Human
Hatano N, Itoh Y, Suzuki H et al. Hypoxia-inducible Factor-1alpha (HIF1alpha) Switches on Transient Receptor Potential Ankyrin Repeat 1 (TRPA1) Gene Expression via a Hypoxia Response Element-like Motif to Modulate Cytokine Release J Biol Chem 2012-09-14 [PMID: 22843691] (WB, Human)	WB	Human
Lee SW, Jeong HK, Lee JY et al. Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF EMBO Mol Med 2012-07-23 [PMID: 22821840] (WB, Mouse)	WB	Mouse
Chen R, Xu M, Hogg RT et al. The Acetylase/Deacetylase Couple CREB-binding Protein/Sirtuin 1 Controls Hypoxia-inducible Factor 2 Signaling J Biol Chem 2012-08-31 [PMID: 22807441] (WB, Human)	WB	Human
Boysen G, Bausch-Fluck D, Thoma CR et al. Identification and Functional Characterization of pVHL-Dependent Cell Surface Proteins in Renal Cell Carcinoma Neoplasia 2012-07-01 [PMID: 22806541] (WB, Human)	WB	Human
Chintala S, Najrana T, Toth K et al. Prolyl hydroxylase 2 dependent and Von-HippelLindau independent degradation of Hypoxiainducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition BMC Cancer 2012-07-17 [PMID: 22804960] (WB, IF/IHC, Human)	WB, IF/IHC	Human
Qi Y, Tian X, Liu J et al. Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis J Cell Biol 2012-07-02 [PMID: 22753893] (IP, Chemotaxis, WB, Mouse)	IP, Chemotaxis, WB	Mouse
Lee J, Jung E, Hyun JW, Park D. Ultraviolet A regulates the stemness of human adipose tissue-derived mesenchymal stem cells through downregulation of the HIF-1 alpha via activation of PGE2-cAMP signaling J Cell Biochem 2012-12-01 [PMID: 22753248] (WB, Human)	WB	Human
Ho JJ, Metcalf JL, Yan MS et al. Functional importance of dicer protein in the adaptive cellular response to hypoxia J Biol Chem 2012-08-17 [PMID: 22745131] (WB, Mouse, Human)	WB	Mouse, Human
Park SJ, Lee KS, Kim SR et al. AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma. Inflamm Res 2012-06-13 [PMID: 22692279] (WB, Mouse)	WB	Mouse
Pourvali K, Matak P, Latunde-Dada GOet al. Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2? FEBS Lett 2012-06-07 [PMID: 22684009] (WB, Human)	WB	Human
Uniacke J, Holterman C, Lachance G, Franovic A, Jacob M, Fabian M, Payette J, Holcik M, Pause A, Lee S. An oxygen-regulated switch in the protein synthesis machinery. Nature doi:10.1038/nature11055. 2012-05-06 [PMID: 22678294] (WB, Human)	WB	Human
Qiyuan Zhou, Tianji Chen, Joyce Christina F Ibe, J Usha Raj, Guofei Zhou. Knockdown of von Hippel-Lindau protein decreases lung cancer cell proliferation and colonization, . FEBS Letters, 10.1016/j.febslet.2012.04.009. 2012-01-01 [PMID: 22673518] (WB, Human)	WB	Human
Xu Y, Li Y, Pang Y et al. EMT and Stem Cell-Like Properties Associated with HIF-2alpha Are Involved in Arsenite-Induced Transformation of Human Bronchial Epithelial Cells. PLoS One. 2012-05-25 [PMID: 22662215] (WB, Human)	WB	Human
Bardella C, Olivero M, Lorenzato A et al. Cells Lacking the Fumarase Tumor Suppressor Are Protected from Apoptosis through a Hypoxia-Inducible Factor-Independent, AMPK-Dependent Mechanism Mol Cell Biol 2012-08-01 [PMID: 22645311] (WB, Human)	WB	Human
Rankin E, Wu C, Khatri R et al. The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis through the Production of EPO Cell 2012-03-30 [PMID: 22464323] (IF/IHC, Mouse)	IF/IHC	Mouse
Xu Y, Li Y, Pang Y et al. Blockade of p53 by HIF-2alpha, but not HIF-1alpha, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells. Arch Toxicol. 2012-03-24 [PMID: 22447124] (WB, Human)	WB	Human
Che Y, Ye F, Xu R et al. Co-expression of XIAP and cyclin D1 complex correlates with a poor prognosis in patients with hepatocellular carcinoma. Am J Pathol 2012-05-01 [PMID: 22429965] (WB, Human)	WB	Human
Natsuizaka M, Naganuma S, Kagawa S et al. Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1a-mediated mRNA transcription and continuous protein synthesis FASEB J. 2012-06-01 [PMID: 22415309]
Yu B, Li MH, Wang W et al. Pseudolaric acid B-driven phosphorylation of c-Jun impairs its role in stabilizing HIF-1alpha: a novel function-converter model J Mol Med (Berl) 2012-03-10 [PMID: 22406864] (WB, Human)	WB	Human
Salman S, Brown ST, Nurse CA. Chronic nicotine induces hypoxia inducible factor-2alpha in perinatal rat adrenal chromaffin cells: role in transcriptional upregulation of KATP channel subunit Kir6.2. Am J Physiol Cell Physiol. 302(10):C1531-8. 2012-05-01 [PMID: 22403787] (WB, Rat)	WB	Rat
Ding Z, German P, Bai S, Feng Z, Gao M, Si W, Sobieski MM, Stephan CC, Mills GB, Jonasch E. Agents That Stabilize Mutated von Hippel-Lindau (VHL) Protein: Results of a High-Throughput Screen to Identify Compounds That Modulate VHL Proteostasis. J Biomol Screen;17(5):572-80. 2012-06-01 [PMID: 22357874] (WB, Human)	WB	Human
Koivunen P, Lee S, Duncan CG et al. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature 2012-03-22 [PMID: 22343896] (IB, Human)	IB	Human
Conley SJ, Gheordunescu E, Kakarala P, et al. Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc Natl Acad Sci U S A. 2012-01-23 [PMID: 22308314] (WB, Mouse)	WB	Mouse
Wiese M, Gerlach RG, Popp I et al. Hypoxia-mediated impairment of the mitochondrial respiratory chain inhibits the bactericidal activity of macrophages Infect Immun 2012-01-17 [PMID: 22252868] (WB, Mouse)	WB	Mouse
Hubbi ME, Gilkes DM, Baek JH, Semenza GL. Four-and-a-Half LIM Domain Proteins Inhibit Transactivation by Hypoxia-Inducible Factor 1. The Journal of Biological Chemistry. 2012-01-04 [PMID: 22219185] (IP, WB, Human)	IP, WB	Human
Ma Y, Liang D, Liu J et al. Prostate Cancer Cell Lines under Hypoxia Exhibit Greater Stem-Like Properties. PLoS ONE 6(12). 2011-01-01 [PMID: 22216200] (IHC-P, Human)	IHC-P	Human
Gabai VL, Meng L, Kim G, Mills TA, Benjamin IJ, Sherman MY. Heat Shock Transcription Factor Hsf1 Is Involved in Tumor Progression via Regulation of Hypoxia-Inducible Factor 1 and RNA-Binding Protein HuR. Mol Cell Biol;32(5):929-40. 2012-03-01 [PMID: 22215620]
Bohonowych JE, Peng S, Gopal U et al. Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation. BMC Cancer;11(1):520. 2011-12-15 [PMID: 22172030]
Zhou W, Dosey TL, Biechele T et al. Assessment of Hypoxia Inducible Factor Levels in Cancer Cell Lines upon Hypoxic Induction Using a Novel Reporter Construct. PLoS ONE 20116(11). [PMID: 22132102] (WB, Human)	WB	Human
Metallo CM, Gameiro PA, Bell EL et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature. doi: 10.1038/nature10602. 2011-11-20 [PMID: 22101433] (WB, Human)	WB	Human
Schrobback K, Malda J, Crawford RW, Upton Z, Leavesley DI, Klein TJ. Effects of Oxygen on Zonal Marker Expression in Human Articular Chondrocytes. Tissue Eng Part A;18(9-10):920-933. 2012-05-01 [PMID: 22097912] (ICC/IF, IHC-Fr, Human)	ICC/IF, IHC-Fr	Human
Kuzmanov A, Wielockx B, Rezaei M et al. Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C. International Journal of Cancer 2011-11-18 [PMID: 22095574] (IB, Mouse)	IB	Mouse
Veeranna RP, Haque M, Davis DA et al. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induction by hypoxia and hypoxia-inducible factors J Virol 2012-01-01 [PMID: 22090111] (Chemotaxis, WB, Human)	Chemotaxis, WB	Human
Sakoda Y, AnS, Zhao Y et al. Herpesvirus entry mediator regulates hypoxia-inducible factor-1[alpha] and erythropoiesis in mice. The Journal of Clinical Investigation. 2011-11-14 [PMID: 22080867] (WB, Mouse)	WB	Mouse
Fujimoto TN, Colbert LE, Molkentine JM, Baseler L. EGLN Inhibition Reduces Gastrointestinal Radiation Toxicity and Improves Survival in a Murine Model of Locally Advanced Pancreatic Cancer bioRxiv 2018-07-20 (WB, Mouse)	WB	Mouse
Subramaniam, N, N The Contribution of LncRNAs to Tip-Stalk Patterning in the Vascular Endothelium Thesis 2022-01-01
Tawari EP. Investigation of chemoresistant mechanisms in triple negative breast. Thesis. 2016-03-01 (WB, ICC/IF, Human)	WB, ICC/IF	Human
Kanno T, Kamba T, Yamasaki T et al. JunB promotes cell invasion and angiogenesis in VHL-defective renal cell carcinoma. Oncogene. 2011-10-24 [PMID: 22020339] (IB, Human)	IB	Human
Farrow EG, Yu X, Summers LJ et al. Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice. Proc Natl Acad Sci U S A 2011-11-15 [PMID: 22006328] (WB, Rat)	WB	Rat
Gerber MM. The Identification of Colorectal Cancer Susceptibility Genes Using a Cross-Species, Systems Genetics Approach. Thesis. 2015-01-01 (WB, Human)