Human TIMP-1 Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human TIMP-1 Quantikine ELISA Kit Summary

• Background: The Quantikine Human TIMP-1 Immunoassay is a 3.5 hour solid phase ELISA designed to measure TIMP-1 concentrations in cell culture supernates, serum, plasma, and saliva. It contains NS0-expressed recombinant human TIMP-1 and antibodies raised against the recombinant factor. It has been shown to quantitate recombinant human TIMP-1 accurately. Results obtained using natural TIMP-1 showed linear... curves that were parallel to the standard curve obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural TIMP-1.
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• Specificity: Natural and recombinant human TIMP-1
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: TIMP1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Interference observed with 1 or more available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human TIMP-1 Quantikine ELISA Kit

• CLGI
• Collagenase inhibitor
• collagenase inhibitor)
• EPATIMP-1
• EPO
• erythroid potentiating activity
• Erythroid-potentiating activity
• Fibroblast collagenase inhibitor
• FLJ90373
• HCI
• metalloproteinase inhibitor 1
• TIMP metallopeptidase inhibitor 1
• TIMP1
• TIMP-1
• TIMPtissue inhibitor of metalloproteinase 1 (erythroid potentiating activity
• Tissue inhibitor of metalloproteinases 1

Background

TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for TIMP-1 (DTM100)(91)

Publications using DTM100

• M Smeda, KM Galler, M Woelflick, A Rosendahl, C Moehle, B Lenhardt, W Buchalla, M Widbiller Molecular Biological Comparison of Dental Pulp- and Apical Papilla-Derived Stem Cells International Journal of Molecular Sciences, 2022;23(5):. 2022 [PMID: 35269758] (Human)
• J Udzik, A Waszczyk, K Safranow, A Biskupski, K Majer, S Kwiatkowsk, E Kwiatkowsk Assessment and Prognosis in CSA-AKI Using Novel Kidney Injury Biomarkers: A Prospective Observational Study Biology, 2021;10(9):. 2021 [PMID: 34571700] (Human)
• K Moriya, N Nishimura, T Namisaki, H Takaya, Y Sawada, H Kawaratani, K Kaji, N Shimozato, S Sato, M Furukawa, A Douhara, T Akahane, A Mitoro, J Yamao, H Yoshiji Zinc Administration and Improved Serum Markers of Hepatic Fibrosis in Patients with Autoimmune Hepatitis Journal of Clinical Medicine, 2021;10(11):. 2021 [PMID: 34199421] (Human)
• J Jarecki, T Ma?ecka-Ma, I Polkowska, B Potoczniak, E Kosior-Jar, I Szerb, E Tomaszewsk, M Gutbier, M Dobrzy?ski, T Blicharski Level of Adiponectin, Leptin and Selected Matrix Metalloproteinases in Female Overweight Patients with Primary Gonarthrosis Journal of Clinical Medicine, 2021;10(6):. 2021 [PMID: 33803785] (Human)
• S Sriphoosan, K Thanapirom, SJ Kerr, S Suksawatam, P Thaimai, S Sittisomwo, K Sonsiri, N Srisoontho, N Teeratorn, N Tanpowpong, B Chaopathom, S Treepraser, Y Poovorawan, P Komolmit Effect of vitamin D supplementation in patients with chronic hepatitis C after direct-acting antiviral treatment: a randomized, double-blind, placebo-controlled trial PeerJ, 2021;9(0):e10709. 2021 [PMID: 33614272] (Human)
• A Waszczykow, M Podgórski, M Waszczykow, Z Gerlicz-Ko, P Jurowski Matrix Metalloproteinases MMP-2 and MMP-9, Their Inhibitors TIMP-1 and TIMP-2, Vascular Endothelial Growth Factor and sVEGFR-2 as Predictive Markers of Ischemic Retinopathy in Patients with Systemic Sclerosis-Case Series Report Int J Mol Sci, 2020;21(22):. 2020 [PMID: 33218057] (Human)
• T Phillips, L Huitema, R Cepeda, DL Cobos, RIM Perez, MS Garza, F Ringpfeil, B Dasgeb, J Uitto, JC Salas-Alan, V Alexeev, O Igoucheva Aberrant recruitment of leukocytes defines poor wound healing in patients with recessive dystrophic epidermolysis bullosa J Dermatol Sci, 2020;0(0):. 2020 [PMID: 33143962] (Human)
• E Rodríguez-, JA Navarro-Ga, J Aceves-Rip, J Abarca-Zab, A Susmozas-S, T Bada-Bosch, E Hernández, E Mérida-Her, A Andrés, M Praga, M Fernández-, JM Aguado, J Segura, LM Ruilope, G Ruiz-Hurta Variations in Circulating Active MMP-9 Levels During Renal Replacement Therapy Biomolecules, 2020;10(4):. 2020 [PMID: 32225016] (Human)
• AE Stanciu, A Zamfir-Chi, MM Stanciu, A Pantea-Sto, C Nitipir, DC Gheorghe Serum melatonin is inversely associated with matrix metalloproteinase-9 in oral squamous cell carcinoma Oncol Lett, 2020;19(4):3011-3020. 2020 [PMID: 32218858] (Human)
• D Moreno-Ajo, P Irimia, JA Rodríguez, MJ García-Vel, J López-Fida, L Fernández-, L Grochowitz, R Muñoz, P Domínguez, J Gállego-Cu, E Martínez-V Elevated circulating metalloproteinase 7 predicts recurrent cardiovascular events in patients with carotid stenosis: a prospective cohort study BMC Cardiovasc Disord, 2020;20(1):93. 2020 [PMID: 32101136] (Human)
• A Kobus, J Bagi?ska, J ?api?ska-A, S ?awicki, A Kierklo Levels of Selected Matrix Metalloproteinases, Their Inhibitors in Saliva, and Oral Status in Juvenile Idiopathic Arthritis Patients vs. Healthy Controls Biomed Res Int, 2019;2019(0):7420345. 2019 [PMID: 31781639] (Human)
• DP Zhang, YF Peng, HL Zhang, JG Ma, M Zhao, S Yin, TT Wei Basilar Artery Tortuosity Is Associated With White Matter Hyperintensities by TIMP-1 Front Neurosci, 2019;13(0):836. 2019 [PMID: 31474817] (Human)
• B Singh, N Ghosh, D Saha, S Sarkar, P Bhattachar, K Chaudhury Effect of doxycyline in chronic obstructive pulmonary disease - An exploratory study Pulm Pharmacol Ther, 2019;0(0):101831. 2019 [PMID: 31349003] (Human)
• B Singh, N Ghosh, D Saha, S Sarkar, P Bhattachar, K Chaudhury Effect of doxycyline in chronic obstructive pulmonary disease - An exploratory study Pulm Pharmacol Ther, 2019;0(0):101831. 2019 [PMID: 31349003] (Human)
• L Lorente, MM Martín, L Ramos, M Argueso, JJ Cáceres, J Solé-Violá, A Jiménez, JM Borreguero, AF González-R, J Orbe, JA Rodríguez, JA Páramo High serum levels of tissue inhibitor of matrix metalloproteinase-1 during the first week of a malignant middle cerebral artery infarction in non-surviving patients BMC Neurol, 2019;19(1):167. 2019 [PMID: 31319804] (Human)
• L Lorente, MM Martín, L Ramos, M Argueso, JJ Cáceres, J Solé-Violá, A Jiménez, JM Borreguero, AF González-R, J Orbe, JA Rodríguez, JA Páramo High serum levels of tissue inhibitor of matrix metalloproteinase-1 during the first week of a malignant middle cerebral artery infarction in non-surviving patients BMC Neurol, 2019;19(1):167. 2019 [PMID: 31319804] (Human)
• M Matulka, A Konopka, B Mroczko, A Pryczynicz, A Kemona, M Groblewska, A Sieskiewic, E Olszewska Expression and Concentration of Matrix Metalloproteinase 9 and Tissue Inhibitor of Matrix Metalloproteinases 1 in Laryngeal Squamous Cell Carcinoma Dis. Markers, 2019;2019(0):3136792. 2019 [PMID: 31143300] (Human)
• M Kunin, V Carmon, P Beckerman, D Dinour Effect of Peritoneal Dialysis on Serum Fibrosis Biomarkers in Patients with Refractory Congestive Heart Failure Int J Mol Sci, 2019;20(11):. 2019 [PMID: 31141909] (Human)
• L Lorente, MM Martín, L Ramos, M Argueso, JJ Cáceres, J Solé-Violá, A Jiménez, JM Borreguero, AF González-R, J Orbe, JA Rodríguez, JA Páramo Persistently high circulating tissue inhibitor of matrix metalloproteinase-1 levels in non-survivor brain trauma injury patients J Crit Care, 2019;51(0):117-121. 2019 [PMID: 30802757] (Human)
• ZJ Liang, X Lu, DD Zhu, XL Yi, FX Wu, N He, C Tang, CY Wei, HM Li Ginsenoside Rg1 Accelerates Paracrine Activity and Adipogenic Differentiation of Human Breast Adipose-Derived Stem Cells in a Dose-Dependent Manner In Vitro Cell Transplant, 2019;0(0):9636897198256. 2019 [PMID: 30675799] (Human)
• CK Wu, MM Su, YF Wu, JJ Hwang, LY Lin Combination of Plasma Biomarkers and Clinical Data for the Detection of Myocardial Fibrosis or Aggravation of Heart Failure Symptoms in Heart Failure with Preserved Ejection Fraction Patients J Clin Med, 2018;7(11):. 2018 [PMID: 30413105] (Human)
• M Zajkowska, E Gacuta, S Koz?owska, E Lubowicka, EK G?a?ewska, L Chrostek, M Szmitkowsk, P Paw?owski, M Zbucka-Kr?, S ?awicki Diagnostic power of VEGF, MMP-9 and TIMP-1 in patients with breast cancer. A multivariate statistical analysis with ROC curve Adv Med Sci, 2018;64(1):1-8. 2018 [PMID: 30227310] (Human)
• Mulyadi, Sunnati, M Azhary, F Yunus, F Nurwidya The correlation of age and body mass index with the level of both protease MMP3 and anti-protease TIMP-1 among Indonesian patients with chronic obstructive pulmonary disease: a preliminary findings BMC Res Notes, 2018;11(1):551. 2018 [PMID: 30071888] (Human)
• EV Nguyen, MM Centenera, M Moldovan, R Das, S Irani, AD Vincent, H Chan, LG Horvath, DJ Lynn, R Daly, LM Butler Identification of novel response and predictive biomarkers to Hsp90 inhibitors through mass spectrometry-based proteomic profiling of patient-derived prostate tumor explants Mol. Cell Proteomics, 2018;0(0):. 2018 [PMID: 29632047] (Human)
• CD Ruediger, B John, S Kumar, HS Lim, G Rangnekar, KC Roberts-Th, GD Young, D Chase, P Sanders, SR Willoughby Influence of ethnic background on left atrial markers of inflammation, endothelial function and tissue remodelling Indian Pacing Electrophysiol J, 2018;18(1):1-5. 2018 [PMID: 29477215] (Human)
• AE Stanciu, RG Vatasescu, MM Stanciu, N Serdarevic, M Dorobantu The role of pro-fibrotic biomarkers in paroxysmal and persistent atrial fibrillation Cytokine, 2018;103(0):63-68. 2018 [PMID: 29324263] (Human)
• G Schmalz, I Davarpanah, J Jäger, RF Mausberg, B Krohn-Grim, J Schmidt, R Haak, U Sack, D Ziebolz MMP-8 and TIMP-1 are associated to periodontal inflammation in patients with rheumatoid arthritis under methotrexate immunosuppression - First results of a cross-sectional study J Microbiol Immunol Infect, 2017;0(0):. 2017 [PMID: 28919284] (Human)
• M Lipczy?ska, P Szyma?ski, M Kumor, A Klisiewicz, P Hoffman Collagen turnover biomarkers and systemic right ventricle remodeling in adults with previous atrial switch procedure for transposition of the great arteries PLoS ONE, 2017;12(8):e0180629. 2017 [PMID: 28767656] (Human)
• S Mailankody, GV Dangeti, R Soundraval, NM Joseph, J Mandal, TK Dutta, T Kadhiravan Cerebrospinal fluid matrix metalloproteinase 9 levels, blood-brain barrier permeability, and treatment outcome in tuberculous meningitis PLoS ONE, 2017;12(7):e0181262. 2017 [PMID: 28704492] (Human)
• M Gusella, C Bolzonella, R Paolini, E Rodella, L Bertolaso, C Scipioni, S Bellini, A Cuneo, F Pasini, E Ramazzina Plasma matrix metalloprotease 9 correlates with blood lymphocytosis, leukemic cell invasiveness, and prognosis in B-cell chronic lymphocytic leukemia Tumour Biol, 2017;39(2):1010428317694. 2017 [PMID: 28240053] (Human)
• ME Niño, SE Serrano, DC Niño, DM McCosham, ME Cardenas, VP Villareal, M Lopez, A Pazin-Filh, FA Jaimes, F Cunha, R Schulz, D Torres-Due TIMP1 and MMP9 are predictors of mortality in septic patients in the emergency department and intensive care unit unlike MMP9/TIMP1 ratio: Multivariate model PLoS ONE, 2017;12(2):e0171191. 2017 [PMID: 28192449] (Human)
• J Mieczkowsk, E Rutkowska, J Mosiewicz, B Mosiewicz Relationship between Serum Levels of Metalloproteinase-8 and Tissue Inhibitor of Metalloproteinases-1 and Exercise Test Results in Postmenopausal Women Dis. Markers, 2016;2016(0):7169531. 2016 [PMID: 28115790] (Human)
• Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment Nat Commun, 2016;7(0):13710. 2016 [PMID: 27966531] (Human)
• Nalluri S, Ghoshal-Gupta S, Kutiyanawalla A, Gayatri S, Lee B, Jiwani S, Rojiani A, Rojiani M TIMP-1 Inhibits Apoptosis in Lung Adenocarcinoma Cells via Interaction with Bcl-2. PLoS ONE, 2015;10(9):e0137673. 2015 [PMID: 26366732] (Human)
• Kmiecik A, Pula B, Suchanski J, Olbromski M, Gomulkiewicz A, Owczarek T, Kruczak A, Ambicka A, Rys J, Ugorski M, Podhorska-Okolow M, Dziegiel P Metallothionein-3 Increases Triple-Negative Breast Cancer Cell Invasiveness via Induction of Metalloproteinase Expression. PLoS ONE, 2015;10(5):e0124865. 2015 [PMID: 25933064] (Human)
• Zhao R, Chen N, Zhou X, Miao P, Hu C, Qian L, Yu Q, Zhang J, Nie H, Chen X, Li P, Xu R, Xiao L, Zhang X, Liu J, Zhang D Exogenous IFN-beta regulates the RANKL-c-Fos-IFN-beta signaling pathway in the collagen antibody-induced arthritis model. J Transl Med, 2014;12(1):330. 2014 [PMID: 25491303] (Human)
• Thevenard J, Verzeaux L, Devy J, Etique N, Jeanne A, Schneider C, Hachet C, Ferracci G, David M, Martiny L, Charpentier E, Khrestchatisky M, Rivera S, Dedieu S, Emonard H Low-density lipoprotein receptor-related protein-1 mediates endocytic clearance of tissue inhibitor of metalloproteinases-1 and promotes its cytokine-like activities. PLoS ONE, 0;9(7):e103839. 0 [PMID: 25075518] (Hamster)
• Uezumi A, Fukada S, Yamamoto N, Ikemoto-Uezumi M, Nakatani M, Morita M, Yamaguchi A, Yamada H, Nishino I, Hamada Y, Tsuchida K Identification and characterization of PDGFRalpha+ mesenchymal progenitors in human skeletal muscle. Cell Death Dis, 2014;5(0):e1186. 2014 [PMID: 24743741] (Human)
• Lorente L, Martin M, Lopez P, Ramos L, Blanquer J, Caceres J, Sole-Violan J, Solera J, Cabrera J, Argueso M, Ortiz R, Mora M, Lubillo S, Jimenez A, Borreguero-Leon J, Gonzalez A, Orbe J, Rodriguez J, Paramo J Association between serum tissue inhibitor of matrix metalloproteinase-1 levels and mortality in patients with severe brain trauma injury. PLoS ONE, 2014;9(4):e94370. 2014 [PMID: 24728097] (Human)
• Symeonidis C, Papakonstantinou E, Androudi S, Tsaousis KT, Tsinopoulos I, Brazitikos P, Karakiulakis G, Diza E, Dimitrakos SA Interleukin-6 and matrix metalloproteinase expression in the subretinal fluid during proliferative vitreoretinopathy: correlation with extent, duration of RRD and PVR grade. Cytokine, 2012;59(1):184-90. 2012 [PMID: 22579111] (Human)
• Jaedicke KM, Taylor JJ, Preshaw PM Validation and quality control of ELISAs for the use with human saliva samples. J. Immunol. Methods, 2012;377(1):62-5. 2012 [PMID: 22306358] (Human)
• Pesta M, Kulda V, Kucera R Prognostic significance of TIMP-1 in non-small cell lung cancer. Anticancer Res., 2011;31(11):4031-8. 2011 [PMID: 22110238] (Human)
• Kong MY, Li Y, Oster R, Gaggar A, Clancy JP Early Elevation of Matrix Metalloproteinase-8 and -9 in Pediatric ARDS Is Associated with an Increased Risk of Prolonged Mechanical Ventilation. PLoS ONE, 2011;6(8):e22596. 2011 [PMID: 21857935] (Human)
• Geraghty P, Dabo AJ, D'Armiento J TLR4 Protein Contributes to Cigarette Smoke-induced Matrix Metalloproteinase-1 (MMP-1) Expression in Chronic Obstructive Pulmonary Disease. J. Biol. Chem., 2011;286(34):30211-8. 2011 [PMID: 21730072] (Human)
• Jonasson S, Lundberg A, Kalvegren H, Bergstrom I, Szymanowski A, Jonasson L Increased levels of leukocyte-derived MMP-9 in patients with stable angina pectoris. PLoS ONE, 2011;6(4):e19340. 2011 [PMID: 21559401] (Human)
• Kluger HM, Hoyt K, Bacchiocchi A, Mayer T, Kirsch J, Kluger Y, Sznol M, Ariyan S, Molinaro A, Halaban R Plasma markers for identifying patients with metastatic melanoma. Clin. Cancer Res., 2011;17(8):2417-25. 2011 [PMID: 21487066] (Human)
• Meissburger B, Stachorski L, Roder E, Rudofsky G, Wolfrum C Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans. Diabetologia, 2011;54(6):1468-79. 2011 [PMID: 21437772] (Human)
• Symeonidis C, Papakonstantinou E, Androudi S, Rotsos T, Diza E, Brazitikos P, Karakiulakis G, Dimitrakos SA Interleukin-6 and the matrix metalloproteinase response in the vitreous during proliferative vitreoretinopathy. Cytokine, 2011;54(2):212-7. 2011 [PMID: 21353595] (Human)
• Hansson J, Vasan RS, Arnlov J, Ingelsson E, Lind L, Larsson A, Michaelsson K, Sundstrom J Biomarkers of extracellular matrix metabolism (MMP-9 and TIMP-1) and risk of stroke, myocardial infarction, and cause-specific mortality: cohort study. PLoS ONE, 2011;6(1):e16185. 2011 [PMID: 21283828] (Human)
• Farlow EC, Vercillo MS, Coon JS, Basu S, Kim AW, Faber LP, Warren WH, Bonomi P, Liptay MJ, Borgia JA A multi-analyte serum test for the detection of non-small cell lung cancer. Br. J. Cancer, 2010;103(8):1221-8. 2010 [PMID: 20859284] (Human)
• Idriss NK, Lip GY, Balakrishnan B Plasma haemoxygenase-1 in coronary artery disease. A comparison with angiogenin, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and vascular endothelial growth factor. Thromb. Haemost., 2010;104(5):1029-37. 2010 [PMID: 20838751] (Human)
• Katial RK, Strand M, Prasertsuntarasai T, Leung R, Zheng W, Alam R The effect of aspirin desensitization on novel biomarkers in aspirin-exacerbated respiratory diseases. J. Allergy Clin. Immunol., 2010;126(4):738-44. 2010 [PMID: 20728206] (Human)
• Mroczko B, Groblewska M, Okulczyk B, Kedra B, Szmitkowski M The diagnostic value of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) determination in the sera of colorectal adenoma and cancer patients. Int J Colorectal Dis, 2010;25(10):1177-84. 2010 [PMID: 20556397] (Human)
• Tolosana JM, Mont L, Sitges M, Berruezo A, Delgado V, Vidal B, Tamborero D, Morales M, Batlle M, Roig E, Castel MA, Perez-Villa F, Godoy M, Brugada J Plasma tissue inhibitor of matrix metalloproteinase-1 (TIMP-1): an independent predictor of poor response to cardiac resynchronization therapy. Eur. J. Heart Fail., 2010;12(5):492-8. 2010 [PMID: 20360066] (Human)
• Teles RM, Teles RB, Amadeu TP, Moura DF, Mendonca-Lima L, Ferreira H, Santos IM, Nery JA, Sarno EN, Sampaio EP High matrix metalloproteinase production correlates with immune activation and leukocyte migration in leprosy reactional lesions. Infect. Immun., 2010;78(3):1012-21. 2010 [PMID: 20008541] (Human)
• Pitteri SJ, JeBailey L, Faca VM, Thorpe JD, Silva MA, Ireton RC, Horton MB, Wang H, Pruitt LC, Zhang Q, Cheng KH, Urban N, Hanash SM, Dinulescu DM Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery. PLoS ONE, 2009;4(11):e7916. 2009 [PMID: 19936259] (Human)
• Reikvam H, Hatfield KJ, Oyan AM, Kalland KH, Kittang AO, Bruserud O Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation. Eur. J. Haematol., 2010;84(3):239-51. 2010 [PMID: 19922462] (Human)
• Lorente L, Martin MM, Labarta L, Diaz C, Sole-Violan J, Blanquer J, Orbe J, Rodriguez JA, Jimenez A, Borreguero-Leon JM, Belmonte F, Medina JC, Lliminana MC, Ferrer-Aguero JM, Ferreres J, Mora ML, Lubillo S, Sanchez M, Barrios Y, Sierra A, Paramo JA Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis. Crit Care, 2009;13(5):R158. 2009 [PMID: 19799791] (Human)
• Roderfeld M, Rath T, Schulz R, Seeger W, Tschuschner A, Graf J, Roeb E Serum matrix metalloproteinases in adult CF patients: Relation to pulmonary exacerbation. J. Cyst. Fibros., 2009;8(5):338-47. 2009 [PMID: 19604728] (Human)
• O'Kane CM, McKeown SW, Perkins GD, Bassford CR, Gao F, Thickett DR, McAuley DF Salbutamol up-regulates matrix metalloproteinase-9 in the alveolar space in the acute respiratory distress syndrome. Crit. Care Med., 2009;37(7):2242-9. 2009 [PMID: 19487934] (Human)
• Gogly B, Fournier B, Couty L, Naveau A, Brasselet C, Durand E, Coulomb B, Lafont A Gingival fibroblast inhibits MMP-7: evaluation in an ex vivo aorta model. J. Mol. Cell. Cardiol., 2009;47(2):296-303. 2009 [PMID: 19397914] (Rabbit)
• Glass-Marmor L, Paperna T, Galboiz Y, Miller A Immunomodulation by chronobiologically-based glucocorticoids treatment for multiple sclerosis relapses. J. Neuroimmunol., 2009;210(1):124-7. 2009 [PMID: 19329193] (Human)
• Kong MY, Gaggar A, Li Y Matrix metalloproteinase activity in pediatric acute lung injury. Int J Med Sci, 2009;6(1):9-17. 2009 [PMID: 19159011]
• Kapsoritakis AN, Kapsoritaki AI, Davidi IP, Lotis VD, Manolakis AC, Mylonis PI, Theodoridou AT, Germenis AE, Potamianos SP Imbalance of tissue inhibitors of metalloproteinases (TIMP) - 1 and - 4 serum levels, in patients with inflammatory bowel disease. BMC Gastroenterol, 2008;8(1):55. 2008 [PMID: 19036126] (Human)
• Castellano G, Malaponte G, Mazzarino MC, Figini M, Marchese F, Gangemi P, Travali S, Stivala F, Canevari S, Libra M Activation of the osteopontin/matrix metalloproteinase-9 pathway correlates with prostate cancer progression. Clin. Cancer Res., 2008;14(22):7470-80. 2008 [PMID: 19010864] (Human)
• McKeown S, Richter AG, O'Kane C, O'Kane C, McAuley DF, Thickett DR MMP expression and abnormal lung permeability are important determinants of outcome in IPF. Eur. Respir. J., 2009;33(1):77-84. 2009 [PMID: 18829682] (Human)
• Huh JE, Baek YH, Kim YJ, Lee JD, Choi DY, Park DS Protective effects of butanol fraction from Betula Platyphyla var. japonica on cartilage alterations in a rabbit collagenase-induced osteoarthritis. J Ethnopharmacol, 2009;123(3):515-21. 2009 [PMID: 18817862] (Rabbit)
• Bendrik C, Robertson J, Gauldie J, Dabrosin C Gene transfer of matrix metalloproteinase-9 induces tumor regression of breast cancer in vivo. Cancer Res., 2008;68(9):3405-12. 2008 [PMID: 18451168] (Human)
• Glader P, Eldh B, Bozinovski S, Andelid K, Sjostrand M, Malmhall C, Anderson GP, Riise GC, Qvarfordt I, Linden A Impact of acute exposure to tobacco smoke on gelatinases in the bronchoalveolar space. Eur. Respir. J., 2008;32(3):644-50. 2008 [PMID: 18417512] (Human)
• Nicol GR, Han M, Kim J, Birse CE, Brand E, Nguyen A, Mesri M, FitzHugh W, Kaminker P, Moore PA, Ruben SM, He T Use of an immunoaffinity-mass spectrometry-based approach for the quantification of protein biomarkers from serum samples of lung cancer patients. Mol. Cell Proteomics, 2008;7(10):1974-82. 2008 [PMID: 18388126] (Human)
• Huh JW, Kim DS, Oh YM, Shim TS, Lim CM, Lee SD, Koh Y, Kim WS, Kim WD, Kim KR Is metalloproteinase-7 specific for idiopathic pulmonary fibrosis? Chest, 2007;133(5):1101-6. 2007 [PMID: 18071010] (Human)
• Goleva E, Hauk PJ, Boguniewicz J, Martin RJ, Leung DY Airway remodeling and lack of bronchodilator response in steroid-resistant asthma. J. Allergy Clin. Immunol., 2007;120(5):1065-72. 2007 [PMID: 17900681] (Human)
• Kellouche S, Martin C, Korb G, Rezzonico R, Bouard D, Benbunan M, Dubertret L, Soler C, Legrand C, Dosquet C Tissue engineering for full-thickness burns: a dermal substitute from bench to bedside. Biochem. Biophys. Res. Commun., 2007;363(3):472-8. 2007 [PMID: 17888881] (Human)
• Thrailkill KM, Bunn RC, Moreau CS, Cockrell GE, Simpson PM, Coleman HN, Frindik JP, Kemp SF, Fowlkes JL Matrix metalloproteinase-2 dysregulation in type 1 diabetes. Diabetes Care, 2007;30(9):2321-6. 2007 [PMID: 17563344] (Human)
• Zhao Z, McCloud B, Fleming R, Klempner MS Borrelia burgdorferi-induced monocyte chemoattractant protein-1 production in vivo and in vitro. Biochem. Biophys. Res. Commun., 2007;358(2):528-33. 2007 [PMID: 17485071] (Human)
• Bodet C, Andrian E, Tanabe S, Grenier D Actinobacillus actinomycetemcomitans lipopolysaccharide regulates matrix metalloproteinase, tissue inhibitors of matrix metalloproteinase, and plasminogen activator production by human gingival fibroblasts: a potential role in connective tissue destruction. J. Cell. Physiol., 2007;212(1):189-94. 2007 [PMID: 17299802] (Human)
• Fearon U, Mullan R, Markham T, Connolly M, Sullivan S, Poole AR, FitzGerald O, Bresnihan B, Veale DJ Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures. Arthritis Rheum., 2006;54(10):3152-62. 2006 [PMID: 17009243] (Human)
• Domeij H, Modeer T, Quezada HC, Yucel-Lindberg T Cell expression of MMP-1 and TIMP-1 in co-cultures of human gingival fibroblasts and monocytes: the involvement of ICAM-1. Biochem. Biophys. Res. Commun., 2005;338(4):1825-33. 2005 [PMID: 16288711] (Human)
• Ko FW, Diba C, Roth M, McKay K, Johnson PR, Salome C, King GG A comparison of airway and serum matrix metalloproteinase-9 activity among normal subjects, asthmatic patients, and patients with asthmatic mucus hypersecretion. Chest, 2005;127(6):1919-27. 2005 [PMID: 15947303] (Human)
• Simpson JL, Scott RJ, Boyle MJ, Gibson PG Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma. Am. J. Respir. Crit. Care Med., 2005;172(5):559-65. 2005 [PMID: 15901607] (Human)
• Rouy D, Ernens I, Jeanty C, Wagner DR Plasma storage at -80 degrees C does not protect matrix metalloproteinase-9 from degradation. Anal. Biochem., 2005;338(2):294-8. 2005 [PMID: 15745750] (Human)
• Sagel SD, Kapsner RK, Osberg I Induced sputum matrix metalloproteinase-9 correlates with lung function and airway inflammation in children with cystic fibrosis. Pediatr. Pulmonol., 2005;39(3):224-32. 2005 [PMID: 15635615] (Human)
• Behera AK, Hildebrand E, Scagliotti J, Steere AC, Hu LT Induction of host matrix metalloproteinases by Borrelia burgdorferi differs in human and murine lyme arthritis. Infect. Immun., 2005;73(1):126-34. 2005 [PMID: 15618147] (Human)
• Kuyvenhoven JP, Molenaar IQ, Verspaget HW, Veldman MG, Palareti G, Legnani C, Moolenburgh SE, Terpstra OT, Lamers CB, van Hoek B, Porte RJ Plasma MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 during human orthotopic liver transplantation. The effect of aprotinin and the relation to ischemia/reperfusion injury. Thromb. Haemost., 2004;91(3):506-13. 2004 [PMID: 14983226] (Human)
• Jumper C, Cobos E, Lox C Determination of the serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in patients with either advanced small-cell lung cancer or non-small-cell lung cancer prior to treatment. Respir Med, 2004;98(2):173-7. 2004 [PMID: 14971882] (Human)
• Tziakas DN, Chalikias GK, Hatzinikolaou HI, Parissis JT, Papadopoulos ED, Trypsianis GA, Papadopoulou E, Tentes IK, Karas SM, Hatseras DI Anti-inflammatory cytokine profile in acute coronary syndromes: behavior of interleukin-10 in association with serum metalloproteinases and proinflammatory cytokines. Int. J. Cardiol., 2003;92(2):169-75. 2003 [PMID: 14659849] (Human)
• Ulrich D, Hrynyschyn K, Pallua N Matrix metalloproteinases and tissue inhibitors of metalloproteinases in sera and tissue of patients with Dupuytren's disease. Plast. Reconstr. Surg., 2003;112(5):1279-86. 2003 [PMID: 14504511] (Human)
• D'Agostino P Matrix metalloproteinases production in malignant pleural effusions after talc pleurodesis. Clin. Exp. Immunol., 2003;134(1):138-42. 2003 [PMID: 12974766] (Human)
• Cataldo DD, Bettiol J, Noel A, Bartsch P, Foidart JM, Louis R Matrix metalloproteinase-9, but not tissue inhibitor of matrix metalloproteinase-1, increases in the sputum from allergic asthmatic patients after allergen challenge. Chest, 2002;122(5):1553-9. 2002 [PMID: 12426252] (Human)
• Fireman E, Kraiem Z, Sade O, Greif J, Fireman Z Induced sputum-retrieved matrix metalloproteinase 9 and tissue metalloproteinase inhibitor 1 in granulomatous diseases. Clin. Exp. Immunol., 2002;130(2):331-7. 2002 [PMID: 12390324] (Human)
• Szamatowicz J, Laudanski P, Tomaszewska I Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1: a possible role in the pathogenesis of endometriosis. Hum. Reprod., 2002;17(2):284-8. 2002 [PMID: 11821264] (Human)

Bioinformatics

• Gene Symbol: TIMP1