Human TIMP-1 Quantikine ELISA Kit

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Catalog# & Conjugate Size Price

Human TIMP-1 Quantikine ELISA Kit Summary

Background
The Quantikine Human TIMP-1 Immunoassay is a 3.5 hour solid phase ELISA designed to measure TIMP-1 concentrations in cell culture supernates, serum, plasma, and saliva. It contains NS0-expressed recombinant human TIMP-1 and antibodies raised against the recombinant factor. It has been shown to quantitate recombinant human TIMP-1 accurately. Results obtained using natural TIMP-1 showed linear... curves that were parallel to the standard curve obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural TIMP-1.
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Specificity
Natural and recombinant human TIMP-1
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
TIMP1

Applications/Dilutions

Application Notes
Interference observed with 1 or more available related molecules.
Publications
Read Publications using DTM100.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human TIMP-1 Quantikine ELISA Kit

  • CLGI
  • Collagenase inhibitor
  • collagenase inhibitor)
  • EPATIMP-1
  • EPO
  • erythroid potentiating activity
  • Erythroid-potentiating activity
  • Fibroblast collagenase inhibitor
  • FLJ90373
  • HCI
  • metalloproteinase inhibitor 1
  • TIMP metallopeptidase inhibitor 1
  • TIMP1
  • TIMP-1
  • TIMPtissue inhibitor of metalloproteinase 1 (erythroid potentiating activity
  • Tissue inhibitor of metalloproteinases 1

Background

TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for TIMP-1 (DTM100)(81)

We have publications tested in 3 confirmed species: Human, Hamster, Rabbit.


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Human
(77)
Hamster
(1)
Rabbit
(2)
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Showing Publications 1 - 10 of 81. Show All 81 Publications.
Publications using DTM100 Applications Species
A Kobus, J Bagi?ska, J ?api?ska-A, S ?awicki, A Kierklo Levels of Selected Matrix Metalloproteinases, Their Inhibitors in Saliva, and Oral Status in Juvenile Idiopathic Arthritis Patients vs. Healthy Controls Biomed Res Int, 2019;2019(0):7420345. 2019 [PMID: 31781639] (Human) Human
DP Zhang, YF Peng, HL Zhang, JG Ma, M Zhao, S Yin, TT Wei Basilar Artery Tortuosity Is Associated With White Matter Hyperintensities by TIMP-1 Front Neurosci, 2019;13(0):836. 2019 [PMID: 31474817] (Human) Human
B Singh, N Ghosh, D Saha, S Sarkar, P Bhattachar, K Chaudhury Effect of doxycyline in chronic obstructive pulmonary disease - An exploratory study Pulm Pharmacol Ther, 2019;0(0):101831. 2019 [PMID: 31349003] (Human) Human
B Singh, N Ghosh, D Saha, S Sarkar, P Bhattachar, K Chaudhury Effect of doxycyline in chronic obstructive pulmonary disease - An exploratory study Pulm Pharmacol Ther, 2019;0(0):101831. 2019 [PMID: 31349003] (Human) Human
L Lorente, MM Martín, L Ramos, M Argueso, JJ Cáceres, J Solé-Violá, A Jiménez, JM Borreguero, AF González-R, J Orbe, JA Rodríguez, JA Páramo High serum levels of tissue inhibitor of matrix metalloproteinase-1 during the first week of a malignant middle cerebral artery infarction in non-surviving patients BMC Neurol, 2019;19(1):167. 2019 [PMID: 31319804] (Human) Human
L Lorente, MM Martín, L Ramos, M Argueso, JJ Cáceres, J Solé-Violá, A Jiménez, JM Borreguero, AF González-R, J Orbe, JA Rodríguez, JA Páramo High serum levels of tissue inhibitor of matrix metalloproteinase-1 during the first week of a malignant middle cerebral artery infarction in non-surviving patients BMC Neurol, 2019;19(1):167. 2019 [PMID: 31319804] (Human) Human
M Matulka, A Konopka, B Mroczko, A Pryczynicz, A Kemona, M Groblewska, A Sieskiewic, E Olszewska Expression and Concentration of Matrix Metalloproteinase 9 and Tissue Inhibitor of Matrix Metalloproteinases 1 in Laryngeal Squamous Cell Carcinoma Dis. Markers, 2019;2019(0):3136792. 2019 [PMID: 31143300] (Human) Human
M Kunin, V Carmon, P Beckerman, D Dinour Effect of Peritoneal Dialysis on Serum Fibrosis Biomarkers in Patients with Refractory Congestive Heart Failure Int J Mol Sci, 2019;20(11):. 2019 [PMID: 31141909] (Human) Human
L Lorente, MM Martín, L Ramos, M Argueso, JJ Cáceres, J Solé-Violá, A Jiménez, JM Borreguero, AF González-R, J Orbe, JA Rodríguez, JA Páramo Persistently high circulating tissue inhibitor of matrix metalloproteinase-1 levels in non-survivor brain trauma injury patients J Crit Care, 2019;51(0):117-121. 2019 [PMID: 30802757] (Human) Human
ZJ Liang, X Lu, DD Zhu, XL Yi, FX Wu, N He, C Tang, CY Wei, HM Li Ginsenoside Rg1 Accelerates Paracrine Activity and Adipogenic Differentiation of Human Breast Adipose-Derived Stem Cells in a Dose-Dependent Manner In Vitro Cell Transplant, 2019;0(0):9636897198256. 2019 [PMID: 30675799] (Human) Human
Show All 81 Publications.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for TIMP-1 (DTM100). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Other Available Formats

HRP DTM100
HRP DTM100
HRP DTM100

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Bioinformatics Tool for TIMP-1 (DTM100)

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Bioinformatics

Gene Symbol TIMP1