BNIP3 Products

Antibodies
BNIP3 Antibody
BNIP3 Antibody
NB100-56150
Species: Hu, Rt, Po, Ch, Xp, Mu(-)
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Lysates
BNIP3 Overexpression Lysate ( ...
BNIP3 Overexpression Lysate (Native)
NBL1-08014
Applications: WB
BNIP3 Overexpression Lysate ( ...
BNIP3 Overexpression Lysate (Denat...
H00000664-T05
Applications: WB
Proteins
BNIP3 Recombinant Protein Ant ...
BNIP3 Recombinant Protein Antigen
NBP1-82566PEP
Species: Hu
Applications: AC

Description

BCL2/adenovirus E1B 19kD protein-interacting protein 3 (BNIP3) is a mitochondrial protein critical for apoptotic events in response to adenovirus infection. It has been implicated in causing a necrotic-like cell death pattern in cells, induced by CD47. This effect has been seen in many cancer cells, and its mis-regulation causes tumor cells to be impervious to normal autophagic events. The tumor suppressor p53 represses the expression of BNIP3, often as a consequence of hypoxic micro-environments as seen in tumors. When BNIP3 is correctly expressed and activated, it translocates to the mitochondria and instigates apoptosis.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 664
Alternate Names
  • BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
  • BCL2/adenovirus E1B 19kD-interacting protein 3
  • Nip3
  • NIP3
  • BCL2/adenovirus E1B 19kDa interacting protein 3

Research Areas for BNIP3

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Autophagy
Cancer
Hypoxia
Phospho-Specific
Tumor Suppressors

Bioinformatics Tool for BNIP3

Discover related pathways, diseases and genes to BNIP3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related BNIP3 Blog Posts

Check out the latest blog posts on BNIP3.
BNIP3 - a regulator of mitochondrial autophagy and cell death
Bcl-2 nineteen-kilodalton interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein. BNIP3 localizes to the mitochondrial membrane where it plays a key role in mitochondrial autophagy and cell death pathways. Similar to other Bcl-2 family m...    Read more.
Read more BNIP3 related blogs.