Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Host: Goat Polyclonal
Species: Hu
Applications: AC
Description
BCL2/adenovirus E1B 19kD protein-interacting protein 3 (BNIP3) is a mitochondrial protein critical for apoptotic events in response to adenovirus infection. It has been implicated in causing a necrotic-like cell death pattern in cells, induced by CD47. This effect has been seen in many cancer cells, and its mis-regulation causes tumor cells to be impervious to normal autophagic events. The tumor suppressor p53 represses the expression of BNIP3, often as a consequence of hypoxic micro-environments as seen in tumors. When BNIP3 is correctly expressed and activated, it translocates to the mitochondria and instigates apoptosis.
Bioinformatics
| Product By Gene ID |
664 |
| Alternate Names |
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
- BCL2/adenovirus E1B 19kDa interacting protein 3
- BCL2/adenovirus E1B 19kD-interacting protein 3
- BNIP3
- Nip3
|
