Lactate Dehydrogenase A/LDHA Products

Description

Lactate dehydrogenase (LDH) is an ubiquitous enzyme commonly found in wide variety of organisms, including plants and microbes. LDH is involved in the interconversion of the pyruvate and NADH to lactate and NAD+. It is also called Hydroxybutyrate Dehydrogenase (HBD), due to the fact that it can catalyze the oxidation of hydroxybutyrate (1). In mammals, three types of LDH subunits (35 kDa) are encoded by the genes Ldh-A, Ldh-B, and Ldh-C, forming various terameric isoenzymes (140 kDa). Lactate dehydrogenase A (LDH-A, muscle subunit, LDH-M) is involved in the final step of anaerobic glycoysis and catalyzes the conversion of L-lactate and NAD to pryruvate and NADH. While it is predominantly expressed in muscle tissue, it is hormonally regulated in rodents and overexpressed during mammary gland tumorigenesis (2). A mutation that cause deficiency in LDH-A has been implicated in exertional myoglobinuria (3).

Bioinformatics

Entrez	16828 Mouse 24533 Rat 3939 Human
Uniprot	NM_005566 Human NM_005566.3 Human NP_005557 Human NP_005557.1 Human P00338 Human
Product By Gene ID	3939
Alternate Names	Cell proliferation-inducing gene 19 protein EC 1.1.1 EC 1.1.1.27 GSD11 lactate dehydrogenase A lactate dehydrogenase M LDH muscle subunit LDH1 LDH-A LDHM LDH-M L-lactate dehydrogenase A chain proliferation-inducing gene 19 Renal carcinoma antigen NY-REN-59

Research Areas for Lactate Dehydrogenase A/LDHA

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