HIF-1 alpha Antibody (H1alpha67)

HIF-1 alpha induction by CoCl2 on Caki-1 cell lysate. WB image submitted by a verified customer review.

HIF-1 alpha was detected in immersion fixed DFO treated Hela cells (left) but was not detected in HIF-1 knockout HeLa cells (right) using Mouse Anti-human HIF-1 alpha monoclonal antibody (Catalog # NB100-105) at 25 ug/mL for 3 hours at room temperature. Cells were stained using a NorthernLights (TM) 557-conjugated Donkey Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to nuclei.

Naive CD4 T cells from WT, VHL-deficient (Vhl KO), or HIF-1 alpha-deficient (HIF-1 alpha KO) mice were differentiated under IL-22-skewing conditions for a total of 60 h. Some cells remained at normoxia for the duration of the culture (N); others were at normoxia for 35 h and then hypoxia (1% O2) for 24 h (H). At 60 h, nuclear extracts were harvested, and HIF-1 alpha and Lamin B1 levels were analyzed by Western blot. Image from verified customer review.

Analysis using the Alexa Fluor (R) 488 conjugate of NB100-105. Staining of HIF-1 alpha in multiple myeloma cells: H929 cells (0.5 x 10^6) were stained with Alexa Fluor 488(R) conjugated HIF-1 alpha antibody (NB100-105AF488). Image courtesy of Dr. Barbara Muz at Washington University in St. Louis School of Medicine.

Staining of HIF-1 alpha in human kidney using NB100-105. Renal tubular epithelium showed moderate membranous, cytoplasmic and nuclear staining, and glomeruli showed faint to moderate nuclear staining.

HIF1alpha/PFKFB3 is upregulated in beta-cells of HIP rats and humans with type 2 diabetes. Representative Western blot of PFKFB3 and HIF1alpha levels in nuclear-enriched- and whole cell extracts from non-diabetic (ND) and T2D donor islets. Data are presented as mean +/- SEM, n = 3 independent biological samples for each group. Statistical significance was analyzed by Student t-test (*p < 0.05, ***p < 0.001) Image collected and cropped by CiteAb from the following publication (//www.nature.com/articles/s41467-019-10444-1) licensed under a CC-BY licence.

Analysis using the biotin conjugate of NB100-105. Staining of human glioblastoma multiforme.

HIF-1 alpha was detected in immersion fixed HeLa human cervical epithelial carcinoma cell line treated with DFOA using 1 ug/mL of mouse anti-HIF-1 alpha monoclonal antibody NB100-105. Cells were stained using a donkey anti-rabbit secondary antibody and counterstained with DAPI (blue).

Upregulation of HIF-1alpha in human PCa. Protein expression of HIF-1alpha, VEGF, and GLUT4 were examined with western blot, in PC-3, DU145, and LNCaP cells after various treatments as indicated. Data are expressed as mean +/- SD of seven independent experiments. $p < 0.05 versus RWPE-1 or BPH1 cells or normal tissue. *p < 0.05 versus control group. #p < 0.05 versus si-HIF-1alpha or DDP group. Original blots are shown in Supplementary Figure 5. C: Ctrl; D: DDP; S: si-HIF-1alpha; D/S: DDP/si-HIF-1alpha. Image collected and cropped by CiteAb from the following publication (//www.nature.com/articles/s41598-017-07973-4), licensed under a CC-BY licence.

Analysis using HIF-1 alpha Antibody on human throat cancer tissue. PFA fixed paraffin-embedded sections. Primary antibody dilution 1:100. Image from verified customer review.

Analysis of HIF-1 alpha in human hepatocytes from cancer patient using anti-HIF-1 alpha antibody NB100-105. Western blot image submitted by a verified customer review.

Analysis using the HRP conjugate of NB100-105. Detection of 50 ug cobalt chloride induced COS-7 nuclear extracts (NB800-PC26) using NB100-105.

L. donovani infection induces HIF-1 alpha expression in CD11chi splenic DCs in an IRF-5 dependent manner. Mice were infected with 2 x 10^7 amastigotes intravenously. Immunoblot analysis of HIF-1 alpha expression in CD11c+ cells from C57BL/6 mice (upper panel) and densitometric analysis normalized to beta-actin expression and expressed as fold increase to results obtained with naive mice (lower panel). Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.ppat.1004938), licensed under a CC-BY licence.

Upregulation of HIF-1alpha in human Pca. HIF-1alpha protein was detected by western blot in nonmalignant (RWPE-1 and BPH1) and PCa cell lines (PC-3, DU145, LNCaP, and 22RV1) as indicated. Image collected and cropped by CiteAb from the following publication (//www.nature.com/articles/s41598-017-07973-4), licensed under a CC-BY licence.

HIF-1alpha expression in PDAC and adjacent normal pancreatic tissue. PDAC with weak (intensity 1) nuclear and cytoplasmic HIF-1alpha staining (left). PDAC with strong (intensity 3) nuclear and moderate (intensity 2) cytoplasmic HIF-1alpha staining (right). Image collected and cropped by CiteAb from the following publication (//wjso.biomedcentral.com/articles/10.1186/s12957-018-1432-4), licensed under a CC-BY licence.

Analysis using the Alexa Fluor(R) 488 conjugate of NB100-105. Staining of HIF-1 alpha in H929 cells using HIF-1 alpha antibody. Flow cytometry image submitted by a verified customer review.

• Reactivity: Hu, Mu, Rt, Po, Bv, Ca, Fe, Ma, Pm, Pm, Rb, Sh, Xp
• Applications: WB, Simple Western, ChIP, ELISA, Flow, Func, GS, ICC/IF, IHC, IP, WB, ChIP, IHC, KD, KO
• Clone: H1alpha67
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: 1.0 mg/ml

HIF-1 alpha Antibody (H1alpha67) Summary

• Immunogen: This HIF-1 alpha Antibody (H1alpha67) was developed against a fusion protein containing amino acids 432 - 528 of human HIF-1 alpha [Uniprot# Q16665].
• Localization: HIF-1 is a nuclear protein
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: HIF1A
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Chromatin Immunoprecipitation (ChIP) 1-5 ug/IP
  • Chromatin Immunoprecipitation 1 - 5 ug/IP. Use reported in scientific literature
  • ELISA 1:100 - 1:2000. Use reported in scientific literature (PMID 20042684)
  • Flow Cytometry 1:10 - 1:1000
  • Gel Super Shift Assays 1:1 - 1:100. Use reported in scientific literature (PMID 22411794)
  • Immunoassay reported in scientific literature (PMID 26147748)
  • Immunoblotting reported in multiple pieces of scientific literature
  • Immunocytochemistry/Immunofluorescence 1:50
  • Immunohistochemistry Free-Floating reported in scientific literature (PMID 33242463)
  • Immunohistochemistry 1:20-1:50
  • Immunohistochemistry-Frozen 1:20-1:50
  • Immunohistochemistry-Paraffin 1:20-1:50
  • Immunoprecipitation 1:10-1:500
  • In vitro assay reported in multiple pieces of scientific literature
  • Knockdown Validated reported in scientific literature (PMID 32772041)
  • Knockout Validated reported in scientific literature (PMID 26861754)
  • Ligand Activation reported in scientific literature (PMID 26147748)
  • Proximity Ligation Assay reported in scientific literature (PMID 27595394)
  • Simple Western
  • Tissue Culture Substratum
  • Western Blot 1:500
• Application Notes: In WB, a band can be seen at 120 kDa representing HIF-1 alpha in induced tissues and cells. Multiple bands may be seen at 100-120 kDa representing post-translational modification of HIF-1 alpha. For WB, testing on nuclear extracts is recommended. We recommend the use of a highly sensitive ECL reagent, such as West Pico PLUS, for Western blot detection. Simple Western reported by an internal validation. Separated by Size
• Theoretical MW: 93 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Control:

  COS-7 Nuclear Hypoxic Induced Cell Lysate
  HeLa CoCl2 treated/Untreated Cell Lysate
  HepG2 CoCl2 treated/Untreated Cell Lysate
  HeLa Hypoxic / Normoxic Cell Lysate
  HepG2 Hypoxic / Normoxic Cell Lysate
  HIF-1 alpha Knockout CoCl2-treated/untreated HeLa Cell Lysate
  HIF-1 alpha Knockout Hypoxic-treated/untreated HeLa Cell Lysate
  NIH 3T3 CoCl2 treated/Untreated Cell Lysate
  L929 CoCl2 treated/Untreated Cell Lysate
  Raw 264.7 CoCl2 treated/Untreated Cell Lysate
  PC12 CoCl2 treated/Untreated Cell Lysate
  PC12 Hypoxic / Normoxic Cell Lysate
  Raw 264.7 Hypoxic / Normoxic Cell Lysate
  L929 Hypoxic / Normoxic Cell Lysate
  NIH 3T3 Hypoxic / Normoxic Cell Lysate

Reactivity Notes

Use in Rat reported in scientific literature (PMID:33816617).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS, 1% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein G purified

Alternate Names for HIF-1 alpha Antibody (H1alpha67)

• AINT
• anti-HIF-1 alpha
• anti-HIF1A
• ARNT interacting protein
• ARNT-interacting protein
• Basic-helix-loop-helix-PAS protein MOP1
• BHLHE78
• Class E basic helix-loop-helix protein 78
• H1alpha67
• HIF 1A
• HIF1 alpha
• HIF-1 alpha
• HIF1
• HIF1A
• HIF-1a
• HIF-1alpha
• HIF-1-alpha
• HIF1-alpha
• hypoxia inducible factor 1 alpha subunit, hypoxia inducible factor 1 subunit alpha
• hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
• hypoxia-inducible factor 1-alpha
• Member of PAS protein 1
• member of PAS superfamily 1
• MOP1
• PAS domain-containing protein 8
• PASD8

Background

Hypoxia contributes to the pathophysiology of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease (1). In cancer and particularly solid tumors, hypoxia plays a critical role in the regulation of genes involved in stem cell renewal, epithelial to mesenchymal transition (EMT), metastasis and angiogenesis. In the tumor microenvironment (TME), hypoxia influences the properties and function of stromal cells (e.g., fibroblasts, endothelial and immune cells) and is a strong determinant of tumor progression (2,3).

HIF-1 or hypoxia inducible factor 1 (predicted molecular weight 93kDa), is a transcription factor commonly referred to as a "master regulator of the hypoxic response" for its central role in the regulation of cellular adaptations to hypoxia. In its active form under hypoxic conditions, HIF-1 is stabilized by the formation of a heterodimer of HIF-1 alpha and ARNT/HIF-1 beta subunits. Nuclear HIF-1 engages p300/CBP for binding to hypoxic response elements (HREs). This process induces transcription and regulation of genes including EPO, VEGF, iNOS2, ANGPT1 and OCT4 (4,5).

Under normoxic conditions, the HIF-1 alpha subunit is rapidly targeted and degraded by the ubiquitin proteasome system. This process is mediated by prolyl hydroxylase domain enzymes (PHDs), which catalyze the hydroxylation of key proline residues (Pro-402 and Pro-564) within the oxygen-dependent degradation domain of HIF-1 alpha. Once hydroxylated, HIF-1 alpha binds the von Hippel-Lindau tumor suppressor protein (pVHL) for subsequent ubiquitination and proteasomal degradation (4). pVHL dependent regulation of HIF-1 alpha plays a role in normal physiology and disease states. Regulation of HIF-1 alpha by pVHL is critical for the suppressive function of FoxP3+ regulatory Tcells (6). Repression of pVHL expression in chronic lymphocytic leukemia (CLL) B cells leads to HIF-1 alpha stabilization and increased VEGF secretion (7).

References

1. Semenza, G. L., Agani, F., Feldser, D., Iyer, N., Kotch, L., Laughner, E., & Yu, A. (2000). Hypoxia, HIF-1, and the pathophysiology of common human diseases. Advances in Experimental Medicine and Biology.

2. Muz, B., de la Puente, P., Azab, F., & Azab, A. K. (2015). The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy. Hypoxia. https://doi.org/10.2147/hp.s93413

3. Huang, Y., Lin, D., & Taniguchi, C. M. (2017). Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe? Science China Life Sciences. https://doi.org/10.1007/s11427-017-9178-y

4. Koyasu, S., Kobayashi, M., Goto, Y., Hiraoka, M., & Harada, H. (2018). Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge. Cancer Science. https://doi.org/10.1111/cas.13483

5. Dengler, V. L., Galbraith, M. D., & Espinosa, J. M. (2014). Transcriptional regulation by hypoxia inducible factors. Critical Reviews in Biochemistry and Molecular Biology. https://doi.org/10.3109/10409238.2013.838205

6. Lee, J. H., Elly, C., Park, Y., & Liu, Y. C. (2015). E3Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1 alpha to Maintain Regulatory T Cell Stability and Suppressive Capacity. Immunity. https://doi.org/10.1016/j.immuni.2015.05.016

7. Ghosh, A. K., Shanafelt, T. D., Cimmino, A., Taccioli, C., Volinia, S., Liu, C. G., ... Kay, N. E. (2009). Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells. Blood. https://doi.org/10.1182/blood-2008-10-185686

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for HIF-1 alpha Antibody (NB100-105)(968)

Publications using NB100-105

• Zhang M, Shi Z, Peng X et al. NLRP3 inflammasome-mediated Pyroptosis induce Notch signal activation in endometriosis angiogenesis Molecular and cellular endocrinology 2023-05-31 [PMID: 37268099] (ICC/IF, WB, Human, Mouse)
  
  Details:
  ICC/IF 1:200, WB 1:1000
• Zhang L, Xu S, Cheng X et al. Inflammatory tumor microenvironment of thyroid cancer promotes cellular dedifferentiation and silencing of iodide-handling genes expression Pathology - Research and Practice 2023-05-01 [PMID: 37172523]
• Zhang H, Wang L, Cui J et al. Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression Science advances 2023-04-05 [PMID: 37018403] (IHC-P, Mouse)
• He S, Fan C, Ji Y et al. SENP3 facilitates M1 macrophage polarization via the HIF-1?/PKM2 axis in lipopolysaccharide-induced acute lung injury Innate immunity 2023-04-05 [PMID: 37016838] (WB, Mouse)
• Qiu M, Li C, Cai Z et al. 3D Biomimetic Calcified Cartilaginous Callus that Induces Type H Vessels Formation and Osteoclastogenesis Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023-03-31 [PMID: 36999832] (IHC-P, Rat)
• Hern�ndez-Roll�n N, S�nchez-Mateos S, L�pez-Morat� M et al. Supplementation of culture medium with quercetin improves mouse blastocyst quality and increases the expression of HIF-1? protein Zygote (Cambridge, England) 2023-02-27 [PMID: 36843100]
• Wu K, Li B, Ma Y et al. Nicotinamide mononucleotide attenuates HIF-1? activation and fibrosis in hypoxic adipose tissue via NAD+/SIRT1 axis Frontiers in endocrinology 2023-01-26 [PMID: 36777361] (IP, Mouse)
• Wu K, Wu M, Yang H et al. Hypoxia promotes conversion to a stem cell phenotype in prostate cancer cells by activating HIF-1?/Notch1 signaling pathway Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2023-02-09 [PMID: 36757381]
• Leca J, Lemonnier F, Meydan C et al. IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment Cancer Cell 2023-02-01 [PMID: 36736318] (IHC-P, Human)
• Wang C, Wu Z, Li Z et al. Beneficial effect of the mitochondrial ATP-sensitive potassium channel-specific opener nicorandil on the collapsed lung via inhibition of apoptosis in clinical thoracic surgery Molecular medicine reports 2023-03-01 [PMID: 36734261]
• Kong Y, Liu PK, Li Y et al. HIF2? activation and mitochondrial deficit due to iron chelation cause retinal atrophy EMBO molecular medicine 2023-02-08 [PMID: 36645044] (WB)
• Sieow J, Penny H, Gun S et al. Conditional Knockout of Hypoxia-Inducible Factor 1-Alpha in Tumor-Infiltrating Neutrophils Protects against Pancreatic Ductal Adenocarcinoma International Journal of Molecular Sciences 2023-01-01 [PMID: 36614196] (IHC-P, Human, Mouse)
  
  Details:
  Dilution used in IHC-P 1:100
• Liu C, Meng M, Xu B et al. Fgf6 Promotes Adipocyte Progenitor Cell Proliferation for Adipose Tissue Homeostasis SSRN Electronic Journal 2022-03-19 [PMID: 36607240]
• Zhong WJ, Liu T, Yang HH et al. TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up glycolysis in acute lung injury International journal of biological sciences 2023-01-01 [PMID: 36594089] (ICC/IF, Mouse)
  
  Details:
  Dilution used in ICC 1:100
• David BT, Curtin JJ, Brown JL et al. Temporary induction of hypoxic adaptations by preconditioning fails to enhance Schwann cell transplant survival after spinal cord injury Glia 2022-12-24 [PMID: 36565279]
• Chen J, Zhang M, Liu Y et al. Histone lactylation driven by mROS-mediated glycolytic shift promotes hypoxic pulmonary hypertension Journal of molecular cell biology 2022-12-23 [PMID: 36564027] (ICC/IF, IP, IHC-P, Rat)
  
  Details:
  Dilution used for IHC-P 1:50
• DAtilo MN, Formigari GP, de Faria JBL, de Faria JML AMP kinase activation by Omega-3 polyunsaturated fatty acid protects the retina against ischemic insult: An in vitro and in vivo study Experimental eye research 2022-12-09 [PMID: 36509164] (ICC/IF, IHC, Mouse, Human)
• Dai T, Rosario SR, Katsuta E et al. Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence Cell reports 2022-12-06 [PMID: 36476868]
• Yang H, Wu Y, Cheng M et al. Roxadustat (FG-4592) protects against ischemia-induced acute kidney injury via improving CD73 and decreasing AIM2 inflammasome activation Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2022-11-22 [PMID: 36413468]
• Igbo BT, Linge A, Frosch S et al. Immunohistochemical analyses of paraffin-embedded sections after primary surgery or trimodality treatment in esophageal carcinoma Clinical and translational radiation oncology 2022-09-01 [PMID: 35993091] (IHC-P, Human)
• Wang P, Zeng G, Yan Y Et al. Disruption of adipocyte HIF-1 alpha improves atherosclerosis through the inhibition of ceramide generation Acta Pharm Sin B 2022-07-18 [PMID: 35847503]
• Wang X, Zhang X, Cao K et al. Cardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy Nature communications 2022-07-08 [PMID: 35803927] (IB, Mouse)
  
  Details:
  Dilution: 1:2000
• Dai T, Rosario S, Katsuta E et al. Hypoxic Tumor Microenvironment Induces Metabolic Enzyme PFKFB4 Acquiring Invasive Cancer Phenotype to Drive Metastasis SSRN Electronic Journal 2022-04-22
• Huang YJ, Chen YT, Huang CM et al. HIF-1 alpha Expression Increases Preoperative Concurrent Chemoradiotherapy Resistance in Hyperglycemic Rectal Cancer Cancers 2022-08-22 [PMID: 36011045] (IHC-P, Human)
  
  Details:
  Dilution used 1:500
• Clinch M The Role of Hypoxia on PORCN and WLS Expression in Human Embryonic Kidney (HEK293T) and Human Colon Cancer (HCT-116T) Cells Carleton University 2022-04-05 (WB, Human)
• Zhang Y, Song Y, Ren S et al. GPER-mediated stabilization of HIF-1 alpha contributes to upregulated aerobic glycolysis in tamoxifen-resistant cells Oncogene 2022-11-18 [PMID: 36400971] (IF/IHC, Human)
• He YL, Li J, Gong SH et al. BNIP3 phosphorylation by JNK1/2 promotes mitophagy via enhancing its stability under hypoxia Cell death & disease 2022-11-17 [PMID: 36396625] (WB, Rat)
  
  Details:
  Dilution used in WB 1:1000
• Tang J, Wu Z, Wang X et al. Hypoxia-Regulated lncRNA USP2-AS1 Drives Head and Neck Squamous Cell Carcinoma Progression Cells 2022-10-28 [PMID: 36359803] (WB, Chemotaxis, Human)
• Vohwinkel CU, Burns N, Coit E et al. HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury JCI insight 2022-11-03 [PMID: 36326834] (WB, Mouse)
• Ji Y, Liang Y, Chu PH Et al. The effects of intermittent hypoxia on hepatic expression of fatty acid translocase CD36 in lean and diet-induced obese mice Biomed J 2022-10-16 [PMID: 36244649] (IHC-P, Mouse)
  
  Details:
  Citation using the HRP version of this antibody.
• Li D, Wang T, Lai J et al. Silencing TRPM2 enhanced erastin- and RSL3-induced ferroptosis in gastric cancer cells through destabilizing HIF-1 alpha and Nrf2 proteins Cytotechnology 2022-08-27 [PMID: 36238268]
• Rosa P, Scibetta S, Pepe G et al. Polysialic Acid Sustains the Hypoxia-Induced Migration and Undifferentiated State of Human Glioblastoma Cells International Journal of Molecular Sciences 2022-08-24 [PMID: 36076963] (WB, IHC-P, Human)
  
  Details:
  WB dilution used 1:1000, IHC-P dilution 1:100
• Wang K, Chen YS, Chien HW et al. Melatonin inhibits NaIO3-induced ARPE-19 cell apoptosis via suppression of HIF-1 alpha/BNIP3-LC3B/mitophagy signaling Cell & bioscience 2022-08-19 [PMID: 35986432] (ICC/IF, WB, Chemotaxis, KD, IF/IHC, Human, Mouse)
• Qin Y, Dinabandhu A, Cao X et al. ANGPTL4 influences the therapeutic response of neovascular age-related macular degeneration patients by promoting choroidal neovascularization JCI insight 2022-06-02 [PMID: 35653189] (IF/IHC, Mouse)
• He WZ, Yang M, Jiang Y et al. miR-188-3p targets skeletal endothelium coupling of angiogenesis and osteogenesis during ageing Cell death & disease 2022-05-25 [PMID: 35610206] (WB, Mouse)
• Jacquier V, Gitenay D, Fritsch S et al. RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53 Cellular and molecular life sciences : CMLS 2022-05-03 [PMID: 35501580] (WB, Mouse)
  
  Details:
  Fig. 1
• Kelly YM, Ward C, Zhang R et al. Effects of Multi-Stage Procurement on the Viability and Function of Human Donor Parathyroid Glands The Journal of surgical research 2022-04-22 [PMID: 35468367] (IHC-P, Human)
• Inada A, Inada O, Yasunami Y et al. Amelioration of murine diabetic nephropathy with a SGLT2 inhibitor is associated with suppressing abnormal expression of hypoxia-inducible factors The American journal of pathology 2022-04-20 [PMID: 35460614] (IF/IHC, Mouse)
• Xia QS, Wu F, Wu WB et al. Berberine reduces hepatic ceramide levels to improve insulin resistance in HFD-fed mice by inhibiting HIF-2 alpha Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022-04-13 [PMID: 35429745] (IHC-P, WB, ICC/IF, Human, Mouse)
• Geng B, Wang X, Park KH et al. UCHL1 protects against ischemic heart injury via activating HIF-1 alpha signal pathway Redox biology 2022-03-18 [PMID: 35339825] (ICC/IF, Human)
• Min, J;Ma, F;Seyran, B;Pellegrini, M;Greeff, O;Moncada, S;Tudzarova, S; beta-cell-specific deletion of PFKFB3 restores cell fitness competition and physiological replication under diabetogenic stress Communications biology [PMID: 35318430] (ICC/IF, Mouse)
• Li M, Su Y, Gao X et al. Transition of autophagy and apoptosis in fibroblasts depends on dominant expression of HIF-1 alpha or p53 Journal of Zhejiang University. Science. B 2022-03-15 [PMID: 35261216] (IHC-P, WB, Human)
• Chen TH, Liu CT, Cheng Cy et al. Oligosaccharides Ameliorate Acute Kidney Injury by Alleviating Cluster of Differentiation 44-Mediated Immune Responses in Renal Tubular Cells Nutrients 2022-02-11 [PMID: 35215410]
• Liu Y, Cong Y, Niu Y et al. Themis is indispensable for IL-2 and IL-15 signaling in T cells Science signaling 2022-02-15 [PMID: 35167340]
• Wei H, Xu Z, Chen L et al. Long non-coding RNA PAARH promotes hepatocellular carcinoma progression and angiogenesis via upregulating HOTTIP and activating HIF-1 alpha/VEGF signaling Cell death & disease 2022-02-02 [PMID: 35110549] (WB, Chemotaxis, Human)
• Burak Kandilci H, Simsek G, Zirapli T, Celebier M Differential role of prolyl hydroxylases on mitochondrial function of HL-1 cells in a model of iron deficiency Mitochondrion 2022-01-20 [PMID: 35066139] (ICC/IF, Mouse)
• Dong X, Wu P, Yan L Et al. Oriented nanofibrous P(MMD-co-LA)/Deferoxamine nerve scaffold facilitates peripheral nerve regeneration by regulating macrophage phenotype and revascularization Biomaterials 2021-12-01 [PMID: 34894585] (IHC-P, Rat)
• Li H, Wang M, Huang B et al. Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis Nature communications 2021-12-09 [PMID: 34887404] (WB, IF/IHC, Mouse)
• Chen Q, Shi F, Yang C Et al. Lentivirus-shRNA mediated prolyl hydroxylase 2 knockdown increases HIF-1 alpha and inhibits nucleus pulposus cells degeneration Cells, tissues, organs 2021-11-15 [PMID: 34781297] (WB)
• Pan Y, Zhu J, Lv Q Et al. Follicle-stimulating hormone regulates glycolysis of water buffalo follicular granulosa cells through AMPK/SIRT1 signalling pathway Reproduction in domestic animals = Zuchthygiene 2021-11-05 [PMID: 34741362]
• Gong Y, Tang N, Liu P Et al. Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells Autophagy 2021-10-31 [PMID: 34720029] (WB, Human)
• Mi C, Cao X, Ma K Et al. Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1 alpha and STAT3 in KRAS mutant human colon cancer cells Chemico-biological interactions 2021-10-28 [PMID: 34717917] (WB)
• D'Amico AG, Maugeri G, RasA DM Et al. Modulatory role of PACAP and VIP on HIFs expression in lung adenocarcinoma Peptides 2021-10-07 [PMID: 34627957] (WB, Human)
• Li Y, Lu Y, Lin SH Et al. Insulin signaling establishes a developmental trajectory of adipose regulatory T cells Nature immunology 2021-09-01 [PMID: 34429546] (Chemotaxis, Mouse)
• Ciminera AK, Shuck SC, Termini J Elevated glucose increases genomic instability by inhibiting nucleotide excision repair Life science alliance 2021-10-01 [PMID: 34426491] (WB, Human)
• Kuo M, Chang W, Wu L Et Al. Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Proximal Tubular Epithelial Cells through miR-545-3p-TNFSF10 Biomolecules 2021-07-15 [PMID: 34356656] (WB)
• Dong W, Song Z, Liu S Et Al. Adipose-Derived Stem Cells Based on Electrospun Biomimetic Scaffold Mediated Endothelial Differentiation Facilitating Regeneration and Repair of Abdominal Wall Defects via HIF-1 alpha/VEGF Pathway Frontiers in bioengineering and biotechnology 2021-07-07 [PMID: 34307320] (ICC/IF)
• Zhou F, Song Y, Liu X Et Al. Si-Wu-Tang facilitates ovarian function through improving ovarian microenvironment and angiogenesis in a mouse model of premature ovarian failure Journal of ethnopharmacology 2021-07-19 [PMID: 34293457] (WB)
• Chen Mh, Wang Yh, Sun Bj Et Al. HIF-1 alpha activator DMOG inhibits alveolar bone resorption in murine periodontitis by regulating macrophage polarization International immunopharmacology 2021-07-14 [PMID: 34273637] (IF/IHC)
• Wang Y, Wang X, Wang H Et Al. PTEN protects kidney against acute kidney injury by alleviating apoptosis and promoting autophagy via regulating HIF1-alpha and mTOR through PI3K/Akt pathway Experimental cell research 2021-07-07 [PMID: 34242625] (WB)
• Veerman KJ. Investigating the Pro-Atherogenic Potential of Chronic Hyperglycemia: Is Diabetic Atherosclerosis a Microvascular Complication? [Internet]. 2011-01-01
• Yu S, Li Q, Wang Y Et Al. Tumor-derived LIF promotes chemoresistance via activating tumor-associated macrophages in gastric cancers Experimental cell research 2021-07-13 [PMID: 34265288] (Chemotaxis, WB)
• Singh A Activation of Hypoxia Inducible Factor pathway for neuroprotection in in vitro models of ischaemic stroke Thesis 2022-01-01 (WB, Rat)
• Kumar Singh R, Pei Y, Bose D Et Al. KSHV-encoded vCyclin can modulate HIF1 alpha levels to promote DNA replication in hypoxia eLife 2021-07-19 [PMID: 34279223] (ICC/IF, WB)
• Penny H, Sieow J, Gun S et al. Targeting Glycolysis in Macrophages Confers Protection Against Pancreatic Ductal Adenocarcinoma International Journal of Molecular Sciences 2021-06-14 [PMID: 34198548] (Mouse)
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  Details:
  Citation using the HRP format of this antibody.
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• Zhang Q, Doucet M, Tomlinson RE et al. The hypoxia-inducible factor-1a activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia Bone Res 2016-07-29 [PMID: 27468359]
• Cui J, Duan B, Zhao X et al. MBD3 mediates epigenetic regulation on EPAS1 promoter in cancer. Tumour Biol 2016-10-01 [PMID: 27465550] (WB, Sheep)
• Takasaki C, Kobayashi M, Ishibashi H et al. Expression of hypoxia-inducible factor-1alpha affects tumor proliferation and antiapoptosis in surgically resected lung cancer. Mol Clin Oncol 2016-08-01 [PMID: 27446567] (IF/IHC)
• Aarup A, Pedersen T X et al Hypoxia-Inducible Factor-1 alpha Expression in Macrophages Promotes Development of Atherosclerosis Arterioscler Thromb Vasc Biol 2016-07-23 [PMID: 27444197] (IF/IHC, IF/IHC, Mouse)
  
  Details:
  Citation using the Biotin version of this antibody.
• Stei MM, Loeffler KU, Kurts C et al. Impact of macrophages on tumor growth characteristics in a murine ocular tumor model Exp. Eye Res. 2016-07-15 [PMID: 27426931] (IF/IHC, Human)
• Hnatiuk AP, Ong SG, Olea FD et al. Allogeneic Mesenchymal Stromal Cells Overexpressing Mutant Human Hypoxia-Inducible Factor 1-alpha (HIF1-alpha) in an Ovine Model of Acute Myocardial Infarction. J Am Heart Assoc 2016-07-06 [PMID: 27385426] (WB)
• Yoon C, Chang KK, Lee JH et al. Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1a inhibition, and hypoxia-activated chemotherapy Oncotarget 2016-07-12 [PMID: 27374091] (WB, Mouse)
• Schokrpur S, Hu J, Moughon DL et al. CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma Sci Rep 2016-06-30 [PMID: 27358011] (ICC/IF, WB)
• Sanagawa A, Iwaki S, Asai M et al. Sphingosine 1phosphate induced by hypoxia increases the expression of PAI1 in HepG2 cells via HIF1a Mol Med Rep 2016-08-01 [PMID: 27357063]
• Ichimaru S, Nakagawa S, Arai Y et al. Hypoxia Potentiates Anabolic Effects of Exogenous Hyaluronic Acid in Rat Articular Cartilage. Int J Mol Sci 2016-06-25 [PMID: 27347945] (WB)
• Maugeri G, Grazia D'Amico A, Reitano R et al. PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Front Pharmacol 2016-05-31 [PMID: 27303300] (WB)
• Hoefflin R, Lahrmann B, Warsow G et al. Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity. Nat Commun 2016-06-13 [PMID: 27291893] (IF/IHC)
• Tan J, Prosser H, Dunn L et al. High-Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I. Diabetes 1905-07-08 [PMID: 27284113]
• Hicks KC, Patel TB. Sprouty 2 Protein Regulates Hypoxia-inducible Factor-alpha (HIF1-alpha) Protein Levels and Transcription of HIF1- alpha responsive Genes J. Biol. Chem. 2016-08-05 [PMID: 27281823] (IP, Human)
• Samanta D, Park Y, Andrabi SA et al. PHGDH Expression is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance and Lung Metastasis. Cancer Res. 2016-06-08 [PMID: 27280394] (WB, Human)
• Lo Dico A, Costa V, Martelli C et al. MiR675-5p Acts on HIF-1 alpha to Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma. Theranostics 2016-06-09 [PMID: 27279905] (ICC/IF, IHC-P)
• Fecher RA, Horwath MC, Friedrich D et al. Inverse Correlation between IL-10 and HIF-1a in Macrophages Infected with Histoplasma capsulatum. J. Immunol. 2016-06-06 [PMID: 27271565] (WB, Mouse)
• Wert Katherine J, Mahajan Vinit B, Zhang Lijuan et al. Neuroretinal hypoxic signaling in a new preclinical murine model for prolifeRative diabetic retinopathy. Signal Transduction and Targeted Therapy 2016-01-01 [PMID: 27195131] (WB, Mouse)
• Badar T, Handisides DR, Benito JM et al. A Phase I Study of Evofosfamide, an Investigational Hypoxia-Activated Prodrug, in Patients with Advanced Leukemia. Am. J. Hematol. 2016-05-11 [PMID: 27169385] (IHC-P, Human)
• Bellanti F, Mirabella L, Mitarotonda D et al. Propofol but not sevoflurane prevents mitochondrial dysfunction and oxidative stress by limiting HIF-1alpha activation in hepatic ischemia/reperfusion injury. Free Radic. Biol. Med. 2016-05-03 [PMID: 27154980]
• Ma J, Mi C, Wang KS et al. Zinc finger protein 91 (ZFP91) activates HIF-1alpha via NF-kB/p65 to promote proliferation and tumorigenesis of colon cancer. Oncotarget. 2016-06-14 [PMID: 27144516] (Human)
• Truong AS, Lockett MR. Oxygen as a chemoattractant: confirming cellular hypoxia in paper-based invasion assays. Analyst. 2016-05-03 [PMID: 27138213] (ICC/IF, Human)
  
  Details:
  This citation used the DyLight 550 version of this antibody.
• Guinot A, Lehmann H, Wild PJ, Frew IJ. Combined deletion of Vhl, Trp53 and kif3a causes cystic and neoplastic renal lesions. J. Pathol. 2016-04-29 [PMID: 27126173] (ICC/IF, IF/IHC, Mouse)
• Mongiardi MP, Savino M, Falchetti ML et al. c-MYC inhibition impairs hypoxia response in glioblastoma multiforme. Oncotarget. 2016-05-31 [PMID: 27119353] (Human)
• Luo B, Wang M, Hou N et al. ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis. Neoplasia. 2016-04-01 [PMID: 27108387] (WB, Human)
• Kowalik MA, Guzzo G, Morandi A et al. Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis. Oncotarget. 2016-05-31 [PMID: 27070090] (Rat)
• Park SJ, Kim JG, Kim ND et al. Estradiol, TGF-beta1 and hypoxia promote breast cancer stemness and EMT-mediated breast cancer migration. Oncol Lett 2016-03-01 [PMID: 26998096] (WB)
• Ananthula S, Sinha A, El Gassim M et al. Geminin overexpression-dependent recruitment and crosstalk with mesenchymal stem cells enhance aggressiveness in triple negative breast cancers. Oncotarget 2016-04-12 [PMID: 26989079] (WB)
• He Z, Jiang X, Huang X et al. Folic Acid Represses Hypoxia-Induced Inflammation in THP-1 Cells through Inhibition of the PI3K/Akt/HIF-1a Pathway. Int J Clin Exp Med 2016-07-30 [PMID: 26974319]
• Zhang X, Liang D, Fan J et al. Zinc Attenuates Tubulointerstitial Fibrosis in Diabetic Nephropathy Via Inhibition of HIF Through PI-3K Signaling. Biol Trace Elem Res 2016-10-01 [PMID: 26956696] (Mouse)
• Karuppagounder SS, Alim I, Khim SJ et al. Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models Sci Transl Med. 2016-03-01 [PMID: 26936506] (WB, Rat)
• Kubo H, Kitajima Y, Kai K et al. Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer. Oncol Lett 2016-02-01 [PMID: 26893686] (WB)
• Chen H, Jia P, Kang H et al. Upregulating Hif-1alpha by Hydrogel Nanofibrous Scaffolds for Rapidly Recruiting Angiogenesis Relative Cells in Diabetic Wound. Adv Healthc Mater 2016-04-20 [PMID: 26891197]
• Fujimoto Y, Urashima T, Shimura D et al. Low Cardiac Output Leads Hepatic Fibrosis in Right Heart Failure Model Rats. PLoS One 2016-02-10 [PMID: 26863419] (WB)
• Mori H, Yao Y, Learman BS et al. Induction of WNT11 by hypoxia and hypoxia-inducible factor-1alpha regulates cell proliferation, migration and invasion. Sci Rep. 2016-02-10 [PMID: 26861754] (WB, Human)
• Mazar J, Qi F, Lee B et al. miR-211 functions as a metabolic switch in human melanoma cells. Mol. Cell. Biol. 2016-01-19 [PMID: 26787841] (WB, Human)
• Morita K, Shirabe K, Taketomi A et al. Relevance of microRNA-18a and microRNA-199a-5p to hepatocellular carcinoma recurrence after living donor liver transplantation. Liver Transpl 2016-05-01 [PMID: 26783726]
• Ai F, Chen M, Li W et al. Danshen improves damaged cardiac angiogenesis and cardiac function induced by myocardial infarction by modulating HIF1alpha/VEGFA signaling pathway. Int J Clin Exp Med 2015-01-01 [PMID: 26770433]
• Chen K, Zeng J, Xiao H et al. Regulation of glucose metabolism by p62/SQSTM1 through HIF1alpha. J. Cell. Sci. 2016-01-07 [PMID: 26743088] (WB, Human)
  
  Details:
  HIF-2 alpha/EPAS1 was used at 1:500 dilution for WB assays in experiments involving human kidney cell lines namely ACHN, Caki-1 and HEK293T.
• Maugeri G, D'Amico AG, Reitano R et al. Parkin modulates expression of HIF-1alpha and HIF-3alpha during hypoxia in gliobastoma-derived cell lines in vitro. Cell Tissue Res. 2016-01-08 [PMID: 26742768] (ICC/IF, WB, Human)
  
  Details:
  HIF-1 alpha (clone H1alpha67) was used at 1:500 dilution for WB assays in lysates from human glioblastoma cell lines U87MG and T98G which were left untransfected or transfected with empty vector (Control shRNA) or with Parkin shRNA (Parkin shRNA) followed by culturing under normoxia or hypoxia conditions. The antibody was used for immunofluorescence analysis (ICC/IF) also on the same cells under similar experimental conditions.
• Lee SB, Frattini V, Bansal M et al. An ID2-dependent mechanism for VHL inactivation in cancer. Nature. 2016-01-14 [PMID: 26735018] (WB, Human)
• Nishi H, Sasaki T, Nagamitsu Y et al. Hypoxia inducible factor-1 mediates upregulation of urokinase-type plasminogen activator receptor gene transcription during hypoxia in cervical cancer cells. Oncol Rep 2016-02-01 [PMID: 26718775]
• Danhier P, Krishnamachary B, Bharti S et al. Combining Optical Reporter Proteins with Different Half-lives to Detect Temporal Evolution of Hypoxia and Reoxygenation in Tumors. Neoplasia. 2015-12-01 [PMID: 26696369] (WB, Human)
• Sharpe MA, Baskin DS. Monoamine oxidase B levels are highly expressed in human gliomas and are correlated with the expression of HiF-1alpha and with transcription factors Sp1 and Sp3. Oncotarget 2016-01-19 [PMID: 26689994] (IF/IHC)
• Mousavizadeh R, Scott A, Lu A et al. Angiopoietin-like 4 promotes angiogenesis in the tendon and is increased in cyclically loaded tendon fibroblasts J. Physiol. (Lond.) 2016-06-01 [PMID: 26670924] (WB)
• Yamano S, Gi M, Tago Y et al. Role of deltaNp63(pos)CD44v(pos) cells in the development of N-nitroso-tris-chloroethylurea-induced peripheral-type mouse lung squamous cell carcinomas. Cancer Sci 2016-02-01 [PMID: 26663681] (IF/IHC)
• Tu Tran Cam, Nagano Masumi, Yamashita Toshiharu et al. A Chemokine Receptor, CXCR4, Which Is Regulated by Hypoxia-Inducible Factor 2a, Is Crucial for Functional Endothelial Progenitor Cells MigRation to Ischemic Tissue and Wound Repair. Stem Cells and Development 2016-01-01 [PMID: 26620723] (Chemotaxis, WB, Mouse)
• Aiken J, Roudier E, Ciccone J et al. Phosphorylation of murine double minute-2 on Ser166 is downstream of VEGF-A in exercised skeletal muscle and regulates primary endothelial cell migration and FoxO gene expression. FASEB J. 2015-11-17 [PMID: 26578686] (WB, Mouse, Human, Rat)
• Clancy KW, Weerapana E, Thompson PR Detection and identification of protein citrullination in complex biological systems. Curr Opin Chem Biol 2016-01-01 [PMID: 26517730]
• Cho MH, Park CK, Park M et al. Clinicopathologic Features and Molecular Characteristics of Glucose Metabolism Contributing to 18F-fluorodeoxyglucose Uptake in Gastrointestinal Stromal Tumors. PLoS ONE. 2015-10-29 [PMID: 26509967] (IHC-P, Human)
• Zhang L, Takara K, Yamakawa D et al. Apelin as a marker for monitoring the tumor vessel normalization window during antiangiogenic therapy. Cancer Sci. 2015-10-17 [PMID: 26475217] (WB, Mouse)
• Kwang Kim K, Abelman S, Yano N et al. Tetrathiomolybdate inhibits mitochondrial complex IV and mediates degradation of hypoxia-inducible factor-1a in cancer cells. Sci Rep. 2015-10-16 [PMID: 26469226] (WB, Human)
• Cui H, Qin Q, Yang M et al. Bortezomib enhances the radiosensitivity of hypoxic cervical cancer cells by inhibiting HIF-1a expression. Int J Clin Exp Pathol 2015-08-15 [PMID: 26464645] (WB, Human)
• Abe T, Kitaoka Y, Kikuchi DM et al. High-intensity interval training-induced metabolic adaptation coupled with an increase in Hif-1alpha and glycolytic protein expression. J Appl Physiol (1985) 2015-12-01 [PMID: 26429867]
• de la Puente P, Muz B, Gilson RC et al 3D tissue-engineered bone marrow as a novel model to study pathophysiology and drug resistance in multiple myeloma. Biomaterials. 2015-12-01 [PMID: 26402156] (IHC-P, Human)
  
  Details:
  Citation using the Alexa Fluor 488 version of this antibody.
• Yu MO, Park KJ, Park DH et al. Reactive oxygen species production has a critical role in hypoxia-induced Stat3 activation and angiogenesis in human glioblastoma. J. Neurooncol. 2015-08-22 [PMID: 26297045] (WB, Human)
  
  Details:
  HIF1 alpha antibody was used for WB on lysates of human glioblastoma cell line U87 subjected to growth in vitro under hypoxic conditions (Fig. 1A).
• Wong CS, Chen A, Liu MC et al. Loss of Siah2 does not impact angiogenic potential of murine endothelial cells. Microvasc. Res. 2015-08-11 [PMID: 26275748] (WB, Mouse)
  
  Details:
  SIAH2 antibody (clone 24E6H3, NB110-88113) was used for WB on lysates of endothelial cells isolated from lungs of wildtype (WT) and Siah2?/? (KO) mice.
• Frey JL, Stonko DP, Faugere MC, Riddle RC Hypoxia-inducible factor-1alpha restricts the anabolic actions of parathyroid hormone. Bone Res 2014-05-13 [PMID: 26273518] (IP)
• Donato MD, Fanelli M, Mariani M et al. Nek6 and Hif-1alpha cooperate with the cytoskeletal gateway of drug resistance to drive outcome in serous ovarian cancer. Am J Cancer Res 2015-01-01 [PMID: 26269749] (IP)
• Belo AI, van Vliet SJ, Maus A et al. Hypoxia inducible factor 1alpha down regulates cell surface expression of alpha1,2-fucosylated glycans in human pancreatic adenocarcinoma cells. FEBS Lett. 2015-08-19 [PMID: 26232512] (ICC/IF, Human)
• Wang IK, Sun KT, Tsai TH et al. MiR-20a-5p mediates hypoxia-induced autophagy by targeting ATG16L1 in ischemic kidney injury Life Sci. 2015-07-10 [PMID: 26165754] (WB, Human)
• Chan MC, Atasoylu O, Hodson E et al. Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain PLoS ONE. 2015-07-07 [PMID: 26147748] (IA, Human)
  
  Details:
  HIF1 alpha antibody was used for auantitative HIF1 alpha meso scale discovery immunoassay on experiments involving RCC4, HeLa, Hep3B, MCF-7 and U2OS cell lines.
• Nakatani K, Watabe T, Masuda D et al. Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice Metab. Clin. Exp. 2015-06-06 [PMID: 26130608] (WB, Mouse)
  
  Details:
  HIF1 alpha antibody was used for WB on protein extraction from cardiac tissues of WT and CD-36 knock-out mice (Fig. 2G).
• Lee JH, Elly C, Park Y, Liu YC. E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1a to Maintain Regulatory T Cell Stability and Suppressive Capacity Immunity. 2015-06-16 [PMID: 26084024] (Chemotaxis, Mouse)
• Bohuslavova R, Skvorova L, Cerychova R, Pavlinkova G. Gene expression profiling of changes induced by maternal diabetes in the embryonic heart. Reprod Toxicol 2015-11-01 [PMID: 26073000]
• Hammami A, Charpentier T, Smans M, Stager S. IRF-5-Mediated Inflammation Limits CD8+ T Cell Expansion by Inducing HIF-1aand Impairing Dendritic Cell Functions during Leishmania Infection PLoS Pathog. 2015-06-01 [PMID: 26046638] (WB, Mouse)
• Espana-Agusti J, Tuveson DA, Adams DJ, Matakidou A. A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules. Sci Rep 2015-01-01 [PMID: 26046460] (IF/IHC, Mouse)
• Fan Y, Wang L, Liu C et al. Local renin-angiotensin system regulates hypoxia-induced vascular endothelial growth factor synthesis in mesenchymal stem cells. Int J Clin Exp Pathol. 2015-06-05 [PMID: 26045756] (WB, Rat)
• Sun L, Xu C, Chen G et al. A Novel Role of OS-9 in the Maintenance of Intestinal Barrier Function from Hypoxia-induced Injury via p38-dependent Pathway. Int. J. Biol. Sci. 2015-05-22 [PMID: 25999789] (WB, Human)
• Joo HY, Yun M, Jeong J et al. SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1alpha (HIF-1alpha) via direct interactions during hypoxia. Biochem. Biophys. Res. Commun. 2015-05-13 [PMID: 25979359] (WB, IP, Human)
• Pang X, Wang Z, Yin D, Zhang Z. Overexpression of hypoxia-inducible factor prolyl- hydoxylase attenuated by HCG-induced vascular endothelial growth factor expression in luteal cells. Mol Med Rep 2015-05-16 [PMID: 25975603]
• Babu E, Bhutia YD, Ramachandran S et al. Deletion of the amino acid transporter Slc6a14 suppresses tumor growth in spontaneous mouse models of breast cancer. Biochem. J. 2015-05-13 [PMID: 25967569] (IHC-P, Mouse)
• Park H, Lee DS, Yim MJ. 3,3'-Diindolylmethane inhibits VEGF expression through the HIF-1alpha and NF-kB pathways in human retinal pigment epithelial cells under chemical hypoxic conditions. Int. J. Mol. Med. 2015-05-05 [PMID: 25955241] (WB, Human)
• Takata S, Masuda T, Nakamura S et al. The effect of triamcinolone acetonide on laser-induced choroidal neovascularization in mice using a hypoxia visualization bio-imaging probe. Sci Rep. 2015-05-01 [PMID: 25927172] (WB, Mouse, Human)
• Liu X, Chen Z, Xu C et al. Repression of hypoxia-inducible factor alpha signaling by Set7-mediated methylation Nucleic Acids Res. 2015-04-20 [PMID: 25897119]
• Brandes F, Schmidt K, Wagner C, et al. Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model. BMC Cancer 2015-02-19 [PMID: 25884642] (WB, Human)
• Shao J, Zhang Y, Yang T et al. HIF-1alpha disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression In Vitro Cell. Dev. Biol. Anim. 2015-04-10 [PMID: 25859979] (Chemotaxis, WB, Mouse)
• Chan N, He S, Spee CK et al. Attenuation of choroidal neovascularization by histone deacetylase inhibitor. PLoS One 2015-01-01 [PMID: 25807249] (WB, Human)
• Lehmann H, Vicari D, Wild PJ, Frew IJ Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation. J Am Soc Nephrol 2015-11-01 [PMID: 25788526]
• Wang F, Zhang G, Xing T et al. Renalase contributes to the renal protection of delayed ischaemic preconditioning via the regulation of hypoxia-inducible factor-1a. J. Cell. Mol. Med. 2015-03-17 [PMID: 25781495] (WB, Human)
• Fillmore N, Huqi A, Jaswal JS et al. Effect of Fatty acids on human bone marrow mesenchymal stem cell energy metabolism and survival. PLoS ONE. 2015-03-15 [PMID: 25768019] (WB, Human)
• Srivastava S, Thakkar B, Yeoh KG et al. Expression of proteins associated with hypoxia and Wnt pathway activation is of prognostic significance in hepatocellular carcinoma Virchows Arch. 2015-03-06 [PMID: 25742908] (IHC-P, Human)
• Paeng SH, Jung WK, Park WS et al. Caffeic acid phenethyl ester reduces the secretion of vascular endothelial growth factor through the inhibition of the ROS, PI3K and HIF-1 alpha signaling pathways in human retinal pigment epithelial cells under hypoxic conditions Int. J. Mol. Med. 2015-05-01 [PMID: 25738890] (WB, Human)
• Rees ML, Subramaniam J, Li Y et al. A PKM2 signature in the failing heart. Biochem Biophys Res Commun 2015-04-10 [PMID: 25735978]
• Hasan AU, Ohmori K, Konishi K et al. Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPARgamma mediated pathways in 3T3-L1 adipocytes Mol. Cell. Endocrinol. 2015-02-16 [PMID: 25697344] (WB, Mouse)
• Li R, Wang Y, Yang Z et al. Hypoxia-inducible factor-1alpha regulates the expression of L-type voltage-dependent Ca(2+) channels in PC12 cells under hypoxia Cell Stress Chaperones. 2015-02-04 [PMID: 25648081] (WB, Rat)
• Beppu T, Sasaki T et al. High-uptake areas on positron emission tomography with the hypoxic radiotracer (18)F-FRP170 in glioblastomas include regions retaining proliferative activity under hypoxia. Ann Nucl Med 2015-01-05 [PMID: 25618012] (IF/IHC, Human)
• Colbert LE, Fisher SB, Balci S et al. High nuclear hypoxia-inducible factor 1 alpha expression is a predictor of distant recurrence in patients with resected pancreatic adenocarcinoma. Int J Radiat Oncol Biol Phys 2015-03-01 [PMID: 25596110] (Human)
• Sohn, E J, Won, G Et al. Upregulation of miRNA3195 and miRNA374b Mediates the Anti-Angiogenic Properties of Melatonin in Hypoxic PC-3 Prostate Cancer Cells. J Cancer 2015-01-02 [PMID: 25553085] (ICC/IF, Human)
• Wang WK, Chen MC, Leong HF et al. Connexin 43 suppresses tumor angiogenesis by down-regulation of vascular endothelial growth factor via hypoxic-induced factor-1a Int J Mol Sci. 2014-12-26 [PMID: 25548899] (ELISA, WB, Mouse)
• Hung YH, Chang SH, Huang CT et al. Inhibitor of Differentiation-1 and Hypoxia-Inducible Factor-1 Mediate Sonic Hedgehog Induction by Amyloid Beta-Peptide in Rat Cortical Neurons. Mol. Neurobiol. 2014-12-15 [PMID: 25502463] (Chemotaxis, Rat)
• Jeong S, Park H, Hong S et al. Lipophilic modification enhances anti-colitic properties of rosmarinic acid by potentiating its HIF-prolyl hydroxylases inhibitory activity. Eur. J. Pharmacol. 2014-12-04 [PMID: 25483211] (WB, Human)
  
  Details:
  HIF1 alpha antibody used for WB in experiments involving human colon carcinoma HCT116 and HT29 cells, human renal cancer UMRC2 cells and UMRC2/VHL cells (stably transfected with VHL)
• Rutz S, Kayagaki N, Phung QT et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 2014-12-03 [PMID: 25470037] (WB, Mouse)
  
  Details:
  HIF1 alpha antibody used for WB on lysates of Duba+/+ and Duba-/- mouse CD4+ T(H)17 cells stimulated with anti-CD3 and anti-CD28 antibodies in the presence of TGF-b and IL-6 (Figure 7).
• Samanta D, Gilkes D, Chaturvedi P, Xiang L, Semenza G. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proc Natl Acad Sci U S A. 2014-12-01 [PMID: 25453096] (WB, Human)
• Gillespie DL, Aguirre MT, Ravichandran S et al. RNA interference targeting hypoxia-inducible factor 1alpha via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model. J. Neurosurg. 2014-11-25 [PMID: 25423275] (IHC-P, Human)
  
  Details:
  HIF1 alpha antibody used for IHC-P on sections of orthotopic mouse model with U87-LucNeo cells subjected to RNAi mediated knock down HIF-1 alpha in vivo
• Wu X, He L, Chen F et al. Impaired autophagy contributes to adverse cardiac remodeling in acute myocardial infarction. PLoS OnE. 2014-11-21 [PMID: 25409294] (WB, Mouse)
• Sato Y, Miyauchi Y, Yoshida S et al. The Vitamin D Analogue ED71 but not 1,25(OH)2D3 Targets HIF1Alpha Protein in Osteoclasts PLoS OnE et al. 2014-11-07 [PMID: 25375896] (WB, Mouse)
• Rahman Su, Lee Ms, Baek Jh et al. The Prolyl Hydroxylase Inhibitor Dimethyloxalylglycine Enhances Dentin Sialophoshoprotein Expression through VEGF-Induced Runx2 Stabilization PLoS OnE et al. 2014-11-05 [PMID: 25369078] (WB, Rat)
  
  Details:
  HIF1 alpha antibody used for WB on the whole cell lysates of MDPC-23 cells (a rat odontoblast-like cell line) incubated for 24 h in the presence or absence of DMOG 0-1 mM concentration (Figure 1B).
• Assar Me, Sanchez-Puelles Jm, Royo I et al. FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/enOS pathway, independently of mTOR/HIF-1Alpha activation Br. J. Pharmacol. 2014-11-03 [PMID: 25363469] (WB, Rat)
  
  Details:
  HIF-1 alpha antibody used for WB on lysates of ex vivo FM19G11 treated aortic and mesenteric arteries from control and insulin-resistant rats (Figure 6).
• Funk K, Scheerer N, Verhaegh R et al. Severe blunt muscle trauma in rats: only marginal hypoxia in the injured area PLoS OnE et al. 2014-11-01 [PMID: 25360779] (IHC-P, Rat)
  
  Details:
  HIF1 alpha antibody used for IHC-P on right Musculus gastrocnemius tissue section of male Wistar rats subjected to severe blunt muscle trauma with standardized weight-drop device - paraformaldehyde-fixed-paraffin-embedded sections, primary antibody dilution of 1:10000, catalyzed signal amplification system from DAKO, staining development with DAB-Hematoxylin (Figure 5).
• Marhold M, Tomasich E, El-Gazzar A et al. HIF-1alpha Regulates mTOR Signaling and Viability of Prostate Cancer Stem Cells. Mol. Cancer Res. 2014-10-27 [PMID: 25349289] (WB, IP, Human, Mouse)
• He YL, Li MM, Wu LY et al. Enhanced Hypoxia-Inducible Factor (HIF)-1 alpha Stability Induced by 5-Hydroxymethyl-2-Furfural (5-HMF) Contributes to Protection against Hypoxia Mol. Med. 2015-03-27 [PMID: 25333920] (WB, ICC/IF, Rat, Mouse)
• Yoshikawa N, Shimizu N, Ojima H et al. Down-regulation of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor by HEXIM1 attenuates myocardial angiogenesis in hypoxic mice. Biochem. Biophys. Res. Commun. 2014-10-06 [PMID: 25301555] (WB, Human)
• Kasper LH, Qu C, Obenauer JC et al. Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression. Nucleic Acids Res. 2014-09-23 [PMID: 25249627] (Chemotaxis, Mouse)
• Bordji K, Grandval A, Cuhna-Alves L et al. Hypoxia-inducible factor-2a (HIF-2a), but not HIF-1a, is essential for hypoxic induction of class III b-tubulin expression in human glioblastoma cells. FEBS J. 2014-09-22 [PMID: 25244496] (WB, GS, Human)
  
  Details:
  HIF-2 alpha/EPAS1 antibody used for WB and EMSA/Gel Super Shift Assay in experiments involving human glioblastoma cell lines - U87MG (p53 wild-type, PTEN mutant) , U251MG (p53 mutant, PTEN mutant) and GL15 (obtained from a frontal lobe tumor biopsy of a 59-year-old man with GBM).
• Shinohara M, Kibi M, Riley IR et al. Cell-Cell Interactions and Bronchoconstrictor Eicosanoid Reduction With Inhaled Carbon Monoxide and Resolvin D1. Am. J. Physiol. Lung Cell Mol. Physiol. 2014-09-12 [PMID: 25217660] (ICC/IF, Human)
• Lee HS, Kim KS, Lim HS et al. Priming Wharton's jelly-derived mesenchymal stromal/stem cells with ROCK inhibitor improves recovery in an intracerebral hemorrhage model. J Cell. Biochem. 2014-09-04 [PMID: 25185536]
• Fujikuni N, Yamamoto H, Tanabe K et al. Hypoxia-mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion. Cancer Sci 2014-11-01 [PMID: 25174257] (WB)
• Queisser MA, Dada LA, Deiss-Yehiely N. HOIL-1L Functions as the PKC-zeta Ubiquitin Ligase to Promote Lung Tumor Growth. Am. J. Respir. Crit. Care Med. 2014-08-13 [PMID: 25118570]
• Huang T, Huang W, Zhang Z et al. Hypoxia-inducible factor-1a upregulation in microglia following hypoxia protects against ischemia-induced cerebral infarction. Neuroreport. 2014-10-01 [PMID: 25089804]
• Gu J, Fan Y, Liu X et al. SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1a-dependent pathway. Cardiovasc. Res. 2014-07-31 [PMID: 25082844] (WB, IP, Rat)
• Yang Xi, Zhu Hongcheng, Ge Yangyang et al. Melittin enhances radiosensitivity of hypoxic head and neck squamous cell carcinoma by suppressing HIF-1alpha. Tumour Biol. 2014-07-23 [PMID: 25053591]
• Zhou W, Marinescu M, Veltkamp R. Only Very Early Oxygen Therapy Attenuates Posthemorrhagic Edema Formation and Blood-Brain Barrier Disruption in Murine Intracerebral Hemorrhage. Neurocrit Care 2014-07-15 [PMID: 25022804] (WB, Mouse)
  
  Details:
  HIF-1 alpha antibody used for WB (1:500 dilution) on lysates of serial coronal cryosections of hemorrhagic and nonhemorrhagic hemispheres from C57BL/6 male mice 3d after inducing Intracerebral Hemorrhage/ ICH (Fig 6B).
• Abu-Remaileh M, Aqeilan RI. Tumor suppressor WWOX regulates glucose metabolism via HIF1alpha modulation. Cell Death Differ 2014-11-01 [PMID: 25012504] (WB)
• Kalamida D, Karagounis IV, Giatromanolaki A, Koukourakis MI. Important role of autophagy in endothelial cell response to ionizing radiation. PLoS ONE 2014-07-11 [PMID: 25010689] (WB, Human)
  
  Details:
  HIF-1 alpha antibody used for WB on lysates of HUVEC/human umbilical vein endothelial cells after exposure to 2 Gy of IR with or without 2 day pre-incubation with SMER28/Small-Molecule Enhancer of Rapamycin-28 (an mTOR-independent inducer of autophagy). Primary antibody was used at 1:500 dilution and the blot images are not shown in the article.
• Privat M, Radosevic-Robin N, Aubel C et al. BRCA1 Induces Major Energetic Metabolism Reprogramming in Breast Cancer Cells. PLoS ONE 2014-07-11 [PMID: 25010005] (WB, Human)
  
  Details:
  HIF-1 alpha antibody used for WB on hypoxia mimetic CoCl2 treated /not treated SUM1315-BRCA1 and SUM1315-LXSN cell lines which were obtained by stable transfection of SUM1315 human breast cancer cells with an empty LXSN plasmid, or a BRCA1-encoding LXSN plasmid (WB image shown in Figure S1).
• Huang Miaoling, Chen Qing, Xiao Jianpeng et al. Overexpression of hypoxia-inducible factor-1alpha is a predictor of poor prognosis in cervical cancer: a clinicopathologic study and a meta-analysis. Int J Gynecol Cancer. 2014-07-01 [PMID: 24978711] (Human)
• Yang MY, Chiao MT, Lee HT et al. An innovative three-dimensional gelatin foam culture system for improved study of glioblastoma stem cell behavior J. Biomed. Mater. Res. Part B Appl. Biomater. 2014-06-26 [PMID: 24966152] (IF/IHC, Human)
  
  Details:
  Laminin antibody used for immunocytochemical/ICC staining (DAB chromogen) of human glioblastoma stem cells/GSCs grown in gelatin foam culture system - 3-D culture environment model. Figure 4 e - Laminin (cell adhesion molecule ) absent in monolayer cultures, but expressed well in GSC mass growth with gelatin cultures.
• Wu JB, Shao C, Li X et al. Near-infrared fluorescence imaging of cancer mediated by tumor hypoxia and HIF1alpha/OATPs signaling axis. Biomaterials. 2014-06-20 [PMID: 24957295] (IHC-P, Human)
  
  Details:
  Archival formalin-fixed paraffin-embedded/FFPE human prostate cancer/PCa specimens were processed for IHC staining with HIF1 alpha antibody (clone H1alpha67, 1:30 dilution).
• Narise Kosuke, Okuda Kensuke, Enomoto Yukihiro et al. Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment. Drug Des Devel Ther. 2014-06-06 [PMID: 24944508] (WB)
• Vorrink SU, Sarsour EH, Olivier AK et al. PCB 126 perturbs hypoxia-induced HIF-1a activity and glucose consumption in human HepG2 cells Exp. Toxicol. Pathol. 2014-06-07 [PMID: 24916446] (IHC-P, Rat)
  
  Details:
  HIF 1 alpha antibody used for FFPE liver sections from male Sprague-Dawley rats treated or not with PCB 126 (AhR agonist ) - HIER using citrate buffer pH 6.0, Peroxidase quenching with 3% H2O2 for 8 min, blocking with 5% horse serum, 1:50 primary - 2 h incubation at RT, detected via Mouse Envision HRP System Reagent -DAB method. Fig 1 - PCB 126 treated livers had mainly cytoplasmic/decreased nuclear staining compared to control rats.
• Salman Shaima, Holloway Alison C, Nurse Colin A. Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2alpha and protein kinase A. Am J Physiol Cell Physiol. 2014-08-01 [PMID: 24898587] (Rat)
• Zhang L, Sun Y, Fei M et al. Disruption of chaperone-mediated autophagy-dependent degradation of MEF2A by oxidative stress-induced lysosome destabilization. Autophagy 2014-06-01 [PMID: 24879151]
• Arreola A, Cowey CL, Coloff JL et al. HIF1alpha and HIF2alpha Exert Distinct Nutrient Preferences in Renal Cells. PLoS ONE. 2014-06-02 [PMID: 24879016] (WB, Mouse)
• Williamson DL, Li Z, Tuder RM et al. Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency J Appl Physiol (1985). 2014-05-28 [PMID: 24876363] (WB, Mouse)
• Xiong Y, Qu Z, Chen N et al. The local corticotropin-releasing hormone receptor 2 signalling pathway partly mediates hypoxia-induced increases in lipolysis via the cAMP-protein kinase A signalling pathway in white adipose tissue. Mol. Cell. Endocrinol. 2014-05-22 [PMID: 24859650] (WB, Rat)
• Xu W, Kwon JH, Moon YH et al. Influence of preoperative transcatheter arterial chemoembolization on gene expression in the HIF-1alpha pathway in patients with hepatocellular carcinoma. J. Cancer Res. Clin. Oncol. 2014-05-23 [PMID: 24853275] (IHC-P, Human)
• Schiffer Davide, Mellai Marta, Annovazzi Laura et al. Stem cell niches in glioblastoma: a neuropathological view. Biomed Res Int. 2014-04-15 [PMID: 24834433] (Human)
• Kim YS, Lee HA, Lim JY et al. beta-Carotene inhibits neuroblastoma cell invasion and metastasis in vitro and in vivo by decreasing level of hypoxia-inducible factor-1alpha. J. Nutr. Biochem. 2014-03-13 [PMID: 24746828] (WB, IHC-P, Human)
• Zheng J, Song F, Lu SL, Wang XQ. Dynamic Hypoxia in Scar Tissue During Human Hypertrophic Scar Progression. Dermatol Surg 2014-03-31 [PMID: 24684437] (IHC-P, Human)
• Chang ML, Chiu CJ, Shang F, Taylor A. High Glucose Activates ChREBP-Mediated HIF-1a and VEGF Expression in Human RPE Cells Under Normoxia. Adv. Exp. Med. Biol. 2014-03-25 [PMID: 24664750] (WB, Human)
• Raspaglio G, Petrillo M, Martinelli E et al. Sox9 and Hif-2a regulate TUBB3 gene expression and affect ovarian cancer aggressiveness. Gene 2014-03-21 [PMID: 24661907] (WB, Human)
• Zhang WG, He L, Shi XM et al. Regulation of transplanted mesenchymal stem cells by the lung progenitor niche in rats with chronic obstructive pulmonary disease. Respir. Res. 2014-03-25 [PMID: 24661402] (IHC-P, WB, Rat)
• Sano M, Sasaki T, Hirakawa S et al. Lymphangiogenesis and angiogenesis in abdominal aortic aneurysm. PLoS ONE 2014-03-21 [PMID: 24651519] (IHC-P, Human)
• Chen Jing, Li Tao, Liu Qilun et al. Clinical and prognostic significance of HIF-1alpha, PTEN, CD44v6, and survivin for gastric cancer: a meta-analysis. PLoS One. 2014-03-19 [PMID: 24647137]
• Pan WL, Wong JH, Fang EF et al. Preferential cytotoxicity of the type I ribosome inactivating protein alpha-momorcharin on human nasopharyngeal carcinoma cells under normoxia and hypoxia. Biochem. Pharmacol. 2014-03-14 [PMID: 24637239] (WB, Human)
• Zhao L, Yang YF, Gao YB et al. Upregulation of HIF-1a Via Activation of ERK and PI3K Pathway Mediated Protective Response to Microwave-Induced Mitochondrial Injury in Neuron-Like Cells. Mol. Neurobiol. 2014-03-14 [PMID: 24627260] (WB, Rat)
• Gauter-Fleckenstein Benjamin, Reboucas Julio S, Fleckenstein Katharina et al. Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+). Redox Biol. 2014-01-09 [PMID: 24624330] (IF/IHC, Rat)
• Shan F, Li J, Huang QY. HIF-1 Alpha-Induced Up-Regulation of miR-9 Contributes to Phenotypic Modulation in Pulmonary Artery Smooth Muscle Cells During Hypoxia. J. Cell. Physiol. 2014-02-25 [PMID: 24615545] (WB, Rat)
• Imamura Y, Tomita S, Imanishi M et al. HIF-2a/ARNT complex regulates hair development via induction of p21Waf1/Cip1 and p27Kip1. FASEB J. 2014-03-05 [PMID: 24599965] (WB, Mouse)
• Huang YH, Lin MH, Wang PC et al. Hypoxia inducible factor 2a/insulin-like growth factor receptor signal loop supports the proliferation and Oct-4 maintenance of mouse germline stem cells. Mol. Hum. Reprod. 2014-03-23 [PMID: 24598112] (WB, Mouse)
• Li Y, Chen J, Zeng T et al. Expression of HIF-1a and MDR1/P-glycoprotein in refractory mesial temporal lobe epilepsy patients and pharmacoresistant temporal lobe epilepsy rat model kindled by coriaria lactone. Neurol. Sci. 2014-03-04 [PMID: 24590840] (WB, Rat)
• Zhao W, Chang C, Cui Y et al. Steroid Receptor Coactivator-3 Regulates Glucose Metabolism in Bladder Cancer Cells through Coactivation of Hypoxia Inducible-Factor 1 alpha. J. Biol. Chem. 2014-03-03 [PMID: 24584933] (Chemotaxis, Human)
• Lall R, Ganapathy S, Yang M et al. Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response. Cell Death Differ. 2014-02-28 [PMID: 24583639] (ICC/IF, Human)
• He M, Lu Y, Xu S et al. MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells. Cell Death Dis 2014-02-28 [PMID: 24577088] (WB, Mouse)
• Zhang Xiaonan, Fryknas Marten, Hernlund Emma et al. Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. Nat Commun. 2014-01-01 [PMID: 24548894]
• Mateo J, Izquierdo-Garcia D, Badimon JJ, Fuster V. Noninvasive Assessment of Hypoxia in Rabbit Advanced Atherosclerosis Using 18F-fluoromisonidazole PET Imaging. Circ Cardiovasc Imaging 2014-02-10 [PMID: 24508668] (IHC-P, Human)
• Bohuslavova Romana, Kolar Frantisek, Sedmera David et al. Partial deficiency of HIF-1alpha stimulates pathological cardiac changes in streptozotocin-induced diabetic mice. BMC Endocr Disord. 2014-02-06 [PMID: 24502509] (WB, Mouse)
• White NM, Masui O, Newsted D et al. Galectin-1 has potential prognostic significance and is implicated in clear cell renal cell carcinoma progression through the HIF/mTOR signaling axis. Br. J. Cancer 2014-03-05 [PMID: 24496460] (WB, Human)
• Weisel FC, Kloepping C, Pichl A et al. Impact of S-Adenosylmethionine Decarboxylase 1 in Pulmonary Vascular Remodeling. Circulation 2014-01-28 [PMID: 24470481] (Chemotaxis, Mouse, Human)
• Wang Enfeng, Zhang Chunyang, Polavaram Navatha et al. The role of factor inhibiting HIF (FIH-1) in inhibiting HIF-1 transcriptional activity in glioblastoma multiforme. PloS One 2014-01-01 [PMID: 24465898] (IP, WB, Human)
• Chen Z, Liu X, Mei Z, Xiao W. EAF2 Suppresses Hypoxia-Induced Factor 1 alpha Transcriptional Activity by Disrupting Its Interaction with Coactivator CBP/p300. Mol. Cell. Biol. 2014-03-01 [PMID: 24421387] (WB, Human)
• Pantel A, Teixeira A, Haddad E et al. Direct type I IFN but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation. PLoS Biol. 2014-01-01 [PMID: 24409099] (FLOW, Mouse)
• Garofalo C, Capristo M, Manara MC et al. Metformin as an Adjuvant Drug against Pediatric Sarcomas: Hypoxia Limits Therapeutic Effects of the Drug. PLoS One 2013-12-31 [PMID: 24391834] (IHC-P, Human)
• Ganapathy S, Xiao S, Yang M et al. A low-dose arsenic induced p53-mediated metabolic mechanism of radiotherapy protection. J Biol Chem 2014-01-03 [PMID: 24391088] (ICC/IF, Human)
• Kind KL, Tam KK, Banwell KM et al. Oxygen-regulated gene expression in murine cumulus cells. Reprod Fertil Dev 2014-01-06 [PMID: 24388334] (WB, Mouse)
• Engelhardt S, Al-Ahmad AJ, Gassmann M, Ogunshola OO. Hypoxia Selectively Disrupts Brain Microvascular Endothelial Tight Junction Complexes Through A Hypoxia-Inducible Factor-1 (HIF-1) Dependent Mechanism. J Cell Physiol 2013-12-25 [PMID: 24375098] (WB, Rat)
• Miyazaki S, Kikuchi H, Iino I et al. Anti-VEGF antibody therapy induces tumor hypoxia and stanniocalcin 2 expression and potentiates growth of human colon cancer xenografts. Int J Cancer 2013-12-20 [PMID: 24375080] (IHC-P, Human)
• Ji X, Wang H, Zhu J et al. Knockdown of Nrf2 suppresses glioblastoma angiogenesis by inhibiting hypoxia-induced activation of HIF-1alpha. Int J Cancer 2013-12-26 [PMID: 24374745] (WB, Human)
• Kawakami T, Yoshimi M, Kadota Y et al. Prolonged endoplasmic reticulum stress alters placental morphology and causes low birth weight. Toxicol Appl Pharmacol 2013-12-23 [PMID: 24370435] (IHC-P, Mouse)
• Ouyang W, Torigoe C, Fang H et al. Anthrax lethal toxin inhibits translation of hypoxia inducible factor 1alpha and causes decreased tolerance to hypoxic stress. J Biol Chem 2013-12-23 [PMID: 24366872] (WB, Mouse)
• Popescu CR, Sutherland MR, Cloutier A et al. Hyperoxia Exposure Impairs Nephrogenesis in the Neonatal Rat: Role of HIF-1alpha. PLoS One 2013-12-17 [PMID: 24358181] (IHC-P, Rat)
• An X, Xu G, Yang L et al. Expression of hypoxia-inducible factor-1alpha, vascular endothelial growth factor and prolyl hydroxylase domain protein 2 in cutaneous squamous cell carcinoma and precursor lesions and their relationship with histological stages and clinical features. J Dermatol 2013-12-20 [PMID: 24354513] (IHC-P, Human)
• Park HJ, Kim MK, Kim SR. Hypoxia Regulates the Expression of the Neuromedin B Receptor through a Mechanism Dependent on Hypoxia-Inducible Factor-1A. PLoS One 2013-12-09 [PMID: 24349381] (Chemotaxis, WB, ICC/IF, IHC-P, Human)
• Fujimura A, Michiue H, Cheng Y et al. Cyclin g2 promotes hypoxia-driven local invasion of glioblastoma by orchestrating cytoskeletal dynamics. Neoplasia 2013-11-01 [PMID: 24339739] (ICC/IF, WB, Human)
• Fernandes BF, Coates J, Odashiro AN et al. Hypoxia-Inducible Factor-1alpha and its Role in the Proliferation of Retinoblastoma Cells. Pathol Oncol Res 2013-12-14 [PMID: 24338218] (WB, Human)
• Chen TM, Shih YH, Tseng JT et al. Overexpression of FGF9 in colon cancer cells is mediated by hypoxia-induced translational activation. Nucleic Acids Res 2013-12-10 [PMID: 24334956] (IF/IHC, Human)
• Takano N, Peng YJ, Kumar GK et al. Hypoxia-inducible factors regulate human and rat cystathionine b-synthase gene expression. Biochem J. 2013-12-12 [PMID: 24328859] (Chemotaxis, WB, Rat, Human)
• Zhang C, Yang X, Zhang Q et al. Berberine radiosensitizes human nasopharyngeal carcinoma by suppressing hypoxia-inducible factor-1alpha expression. Acta Otolaryngol 2014-02-01 [PMID: 24325635] (WB, Human)
• Chen Z, He X, Xia W et al. Prognostic Value and Clinicopathological Differences of HIFs in Colorectal Cancer: Evidence from Meta-Analysis. PLoS One 2013-12-06 [PMID: 24324596] (IF/IHC, Human)
• Jensen RL, Mumert ML, Gillespie DL et al. Preoperative dynamic contrast-enhanced MRI correlates with molecular markers of hypoxia and vascularity in specific areas of intratumoral microenvironment and is predictive of patient outcome. Neuro Oncol 2013-12-04 [PMID: 24305704] (IHC-P, Human)
• Watson CJ, Collier P, Tea I et al. Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype. Hum Mol Genet 2013-12-16 [PMID: 24301681] (WB, Human)
• Ma Z, Moruzzi N, Catrina SB et al. Hyperoxia inhibits glucose-induced insulin secretion and mitochondrial metabolism in rat pancreatic islets. Biochem Biophys Res Commun. 2013-12-02 [PMID: 24299957] (WB, Rat)
• Przybyla Beata D, Shafirstein Gal, Vishal Sagar J et al. Molecular changes in bone marrow, tumor and serum after conductive ablation of murine 4T1 breast carcinoma. Int J Oncol. 2014-02-01 [PMID: 24270800] (WB)
• Bertozzi D, Marinello J, Manzo SG et al. The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1 alpha activity by changing miR expression patterns in human cancer cells. Mol. Cancer Ther. 2014-01-01 [PMID: 24252850] (WB, Human)
• Liu X, Tu Y, Zhang L et al. Prolyl Hydroxylase Inhibitors Protect from the Bone Loss in Ovariectomy Rats by Increasing Bone Vascularity. Cell Biochem Biophys. 2013-11-16 [PMID: 24242187] (WB, Rat)
• Koide N, Odkhuu E, Naiki Y et al. Augmentation of LPS-induced vascular endothelial cell growth factor production in macrophages by transforming growth factor-beta1. Innate Immun. 2013-11-13 [PMID: 24225655] (WB, Mouse)
• Zhang Y, Marsboom G, Toth PT, Rehman J. Mitochondrial respiration regulates adipogenic differentiation of Human mesenchymal stem cells. PLoS One. 2013-10-18 [PMID: 24204740] (ICC/IF, Human)
• Park EY, Lee CH, Lee EK et al. HNF4alpha contributes to glucose formation in aged rat hepatocytes. Exp Gerontol 2013-12-01 [PMID: 24177414] (WB, Rat)
• Huang SM, Chen TS, Chiu CM et al. GDNF increases cell motility in human colon cancer through VEGF-VEGFR1 interaction. Endocr. Relat. Cancer 2014-02-01 [PMID: 24165321] (WB, Human)
• Madej JA, Madej JP, Dziegiel P et al. Expression of hypoxia-inducible factor-1alpha and vascular density in mammary adenomas and adenocarcinomas in bitches. Acta Vet Scand. 2013-10-24 [PMID: 24153191] (IHC-P, Canine)
• Cheng YL, Park JS, Manzanero S et al. Evidence that collaboration between HIF-1 alpha and Notch-1 promotes neuronal cell death in ischemic stroke. Neurobiol. Dis. 2014-02-01 [PMID: 24141018] (WB, ICC/IF, Mouse)
• Eckle T, Brodsky K, Bonney M et al. HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium. PLoS Biol. 2013-09-01 [PMID: 24086109] (WB, IHC-P, Human, Mouse)
• Zhang L, Xu J, Sun N et al. The Presence of Adenosine A2a Receptor in Thyrocytes and Its Involvement in Graves' IgG-Induced VEGF Expression. Endocrinology. 2013-09-30 [PMID: 24080368] (IHC-P, WB, ICC/IF, Mouse, Human)
• Hu P, Chung LW, Berel D et al. Convergent RANK- and c-Met-Mediated Signaling Components Predict Survival of Patients with Prostate Cancer: An Interracial Comparative Study. PLoS One. 2013-09-16 [PMID: 24066029] (Human)
• Wall AM, Corcoran AE, O'Halloran KD, O'Connor JJ. Effects of prolyl-hydroxylase inhibition and chronic intermittent hypoxia on synaptic transmission and plasticity in the rat CA1 and dentate gyrus. Neurobiol Dis. 2013-09-17 [PMID: 24055213] (WB, Rat)
• Gallaher AM, Das S, Xiao Z et al. Proteomic Screening of Human Targets of Viral microRNAs Reveals Functions Associated with Immune Evasion and Angiogenesis. PLoS Pathog. 2013-09-01 [PMID: 24039573] (WB, Human)
• Cowburn AS, Alexander LE, Southwood M et al. Epidermal Deletion of HIF-2alpha Stimulates Wound Closure. J Invest Dermatol. 2013-09-13 [PMID: 24037341] (IHC-P, Mouse)
• Minoia C, Quero C, Asselti M et al. Changes in angiogenesis and Hypoxia-Inducible Factor-1alpha protein expression in relapsed/refractory indolent non-Hodgkin Lymphomas. Br J Haematol. 2013-09-13 [PMID: 24033233] (IF/IHC, Human)
• Yang X, Yang B, Cai J et al. Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1alpha in vitro and in vivo. Cancer Biol Ther 2013-11-01 [PMID: 24025355] (Mouse)
• Miyauchi Y, Sato Y, Kobayashi T et al. HIF1alpha is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis. Proc Natl Acad Sci U S A. 2013-10-08 [PMID: 24023068] (IHC-P, WB, ICC/IF, Mouse)
• Tan JT, Prosser HC, Vanags LZ et al. High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1alpha. FASEB J. 2013-09-10 [PMID: 24022405] (WB, Human)
• Ding G, Huang G, Liu HD et al. MiR-199a suppresses the hypoxia-induced proliferation of non-small cell lung cancer cells through targeting HIF1alpha. Mol Cell Biochem. 2013-09-11 [PMID: 24022342] (IF/IHC, WB, Human)
• Wang Wen-Sheng, Liang Hong-Yin, Cai Yu-Jiao, Yang Hua. DMOG ameliorates IFN-gamma-induced intestinal barrier dysfunction by suppressing PHD2-dependent HIF-1alpha degradation. J Interferon Cytokine Res. 2014-01-01 [PMID: 24010824] (Human)
• Lin WP, Wang XJ, Wang CR et al. Polymorphism in the Hypoxia-Inducible Factor 1alpha Gene May Confer Susceptibility to LDD in Chinese Cohort. PLoS One. 2013-08-26 [PMID: 23991178] (WB, Human)
• Pawlus MR, Wang L, Murakami A. STAT3 or USF2 Contributes to HIF Target Gene Specificity. PLoS One 2013-08-21 [PMID: 23991099] (Chemotaxis, Human)
  
  Details:
  Using the Biotin conjugated version of NB100-134, catalog number NB100-134B.
• Cao Y, Eble JM, Moon E et al. Tumor Cells Upregulate Normoxic HIF-1alpha in Response to Doxorubicin. Cancer Res. 2013-08-19 [PMID: 23959856] (WB, Mouse, Human)
• Wang SC, Yu CF, Hong JH et al. Radiation Therapy-Induced Tumor Invasiveness Is Associated with SDF-1-Regulated Macrophage Mobilization and Vasculogenesis. PLoS One. 2013-08-05 [PMID: 23940516] (WB, Mouse)
• Shin JM, Jeong YJ, Cho HJ et al. Melittin Suppresses HIF-1alpha/VEGF Expression through Inhibition of ERK and mTOR/p70S6K Pathway in Human Cervical Carcinoma Cells. PLoS One 2013-07-23 [PMID: 23936001] (Chemotaxis, Human)
• Ma Z, Moruzzi N, Catrina SB et al. Preconditioning with Associated Blocking of Ca2+ Inflow Alleviates Hypoxia-Induced Damage to Pancreatic beta-Cells. PLoS One 2013-07-25 [PMID: 23935835] (WB, Rat)
• Jung JH, Im S, Jung ES, Kang CS. Clinicopathological Implications of the Expression of Hypoxia-related Proteins in Gastric Cancer. Int J Med Sci 2013-07-31 [PMID: 23935399] (IHC-P, Human)
• Takibuchi G, Imanishi H, Morimoto M et al. Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype. Mitochondrion. 2013-08-06 [PMID: 23932994] (WB, Mouse)
• Zaccagnini G, Maimone B, Di Stefano V et al. Hypoxia-induced miR-210 modulates tissue response to acute peripheral ischemia. Antioxid Redox Signal. 2013-08-10 [PMID: 23931770]
• Al-Greene NT, Means AL, Lu P et al. Four Jointed Box 1 Promotes Angiogenesis and Is Associated with Poor Patient Survival in Colorectal Carcinoma. PLoS One 2013-07-29 [PMID: 23922772] (WB, Human)
• Belloli S, Brioschi A, Politi LS et al. Characterization of biological features of a rat F98 GBM model: A PET-MRI study with [(18)F]FAZA and [(18)F]FDG. Nucl Med Biol 2013-08-01 [PMID: 23915802] (IHC-P, Rat)
• Sun YY, Lin SH, Lin HC et al. Cell Type-Specific Dependency on the PI3K/Akt Signaling Pathway for the Endogenous Epo and VEGF Induction by Baicalein in Neurons versus Astrocytes. PLoS One 2013-07-19 [PMID: 23904909] (Chemotaxis, Rat)
• Park YK, Park B, Lee SY et al. Hypoxia-Inducible Factor-2alpha-Dependent Hypoxic Induction of Wnt10b Expression in Adipogenic Cells. J Biol Chem 2013-07-30 [PMID: 23900840] (WB, Mouse)
• Xu H, Li B, Yu W et al. Correlation between 18F-FDG uptake and the expression of glucose transporter-1 and hypoxia-inducible factor-1alpha in transplanted VX2 tumors. Nucl Med Commun 2013-07-24 [PMID: 23887273] (IHC-P, Rabbit)
• You Q, Holt M, Yin H et al. Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem Pharmacol 2013-07-19 [PMID: 23876342] (WB, Mouse)
• Allon I, Kaplan I, Allon D et al. HIF-1alpha, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia. Oral Dis 2013-06-25 [PMID: 23837804] (IHC-P, Human)
• Takikawa T, Masamune A, Hamada S et al. miR-210 regulates the interaction between pancreatic cancer cells and stellate cells. Biochem Biophys Res Commun 2013-07-04 [PMID: 23831622] (ICC/IF, Human)
• Wang W, McKinnie SM, Patel VB et al. Loss of Apelin Exacerbates Myocardial Infarction Adverse Remodeling and Ischemia-reperfusion Injury: Therapeutic Potential of Synthetic Apelin Analogues. J Am Heart Assoc 2013-07-01 [PMID: 23817469] (ICC/IF, IHC-P, WB, Mouse)
• Xie L, Collins JF. Transcription Factors Sp1 and Hif2alpha Mediate Induction of the Copper-Transporting ATPase (Atp7a) Gene in Intestinal Epithelial Cells During Hypoxia. J Biol Chem 2013-06-28 [PMID: 23814049] (WB, Rat)
• Sundelin JP, Lidberg U, Nik AM et al. Hypoxia-induced regulation of the very low density lipoprotein receptor. Biochem Biophys Res Commun 2013-06-27 [PMID: 23811271] (Chemotaxis, Mouse)
• Wu C, Zhou Y, Chang J, Xiao Y. Delivery of dimethyloxallyl glycine in mesoporous bioactive glass scaffolds to improve angiogenesis and osteogenesis of human bone marrow stromal cells. Acta Biomater 2013-06-26 [PMID: 23811216] (WB, Human)
• Kondrashina AV, Papkovsky DB, Dmitriev RI. Measurement of cell respiration and oxygenation in standard multichannel biochips using phosphorescent O2-sensitive probes. Analyst 2013-06-27 [PMID: 23803790]
• Sato Y, Yoshizato T, Shiraishi Y et al. Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet 2013-06-24 [PMID: 23797736] (IF/IHC, Human)
• Shimomura M, Hinoi T, Kuroda S et al. Overexpression of Hypoxia Inducible Factor-1 Alpha is an Independent Risk Factor for Recurrence After Curative Resection of Colorectal Liver Metastases. Ann Surg Oncol 2013-06-09 [PMID: 23748663] (IHC-P, Human)
• Zhang H, Tang L, Chen S et al. Effect of advanced glycation end products on the expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor proteins in RF/6A cells. Exp Ther Med 2013-05-01 [PMID: 23737911] (WB, ICC/IF, Primate)
• Park GC, Lee M, Roh JL, et al. Phospho-Rb (Ser780) as a biomarker in patients with cervical lymph node metastases from an unknown primary tumour: a retrospective cohort study. Clin Otolaryngol 2013-06-04 [PMID: 23731755] (IHC-P, Human)
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  Details:
  Citation using the DyLight 550 version of this antibody.
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• Pacary, E et al. Synergistic effects of CoCl(2) and ROCK inhibition on mesenchymal stem cell differentiation into neuron-like cells. J. Cell Sci. 119: 2667-2678. 2006-01-01 [PMID: 16772336] (WB, ICC/IF, Mouse)
• Bernhardt WM, Campean V, Kany S et al. Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. J Am Soc Nephrol;17(7):1970-8. 2006-07-01 [PMID: 16762988] (IHC-P, Rat)
• Bracken CP, Fedele AO, Linke S et al. Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha HIF-2alpha stabilization transactivation in a graded oxygen environment. J Biol Chem;281(32):22575-85. 2006-08-11 [PMID: 16760477] (WB, Human)
• Nishimura, R et al. Oxygen concentration is an important factor for modulating progesterone synthesis in bovine corpus luteum. Endocrinology;147(9):4273-80. 2006-09-01 [PMID: 16740971] (WB, Bovine)
• Stevens HY, Meays DR, Frangos JA. Pressure gradients and transport in the murine femur upon hindlimb suspension. Bone 2006-09-01 [PMID: 16677866] (ICC/IF, Mouse)
• Wang, R et al. Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia. FASEB J; 20: 1275-1277. 2006-01-01 [PMID: 16645044] (WB, Human)
• Grammas P, Samany PG, Thirumangalakudi L. Thrombin and inflammatory proteins are elevated in Alzheimer's disease microvessels: implications for disease pathogenesis. J Alzheimers Dis 2006-03-01 [PMID: 16627934]
• Fernando MS, Simpson JE, Matthews F et al. White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. Stroke 2006-06-01 [PMID: 16627790] (Human)
• Hu CJ, Iyer S, Sataur A et al. Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells Mol Cell Biol 2006-05-01 [PMID: 16611993] (WB, IP, Mouse)
• Zampino M, Yuzhakova M, Hansen J et al. Sex-related dimorphic response of HIF-1 alpha expression in myocardial ischemia. Am J Physiol Heart Circ Physiol 2006-08-01 [PMID: 16603692] (ICC/IF, IF/IHC, Rat)
• Franco M, Man S, Chen L et al. Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia. Cancer Res 2006-04-01 [PMID: 16585189] (WB, Human)
• Schoppmann SF, Fenzl A, Schindl M et al. Hypoxia inducible factor-1alpha correlates with VEGF-C expression and lymphangiogenesis in breast cancer. Breast Cancer Res Treat 2006-09-01 [PMID: 16555123] (IF/IHC, Human)
• Fath, D M et al. Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha. J Biol Chem 281: 13612-13619. [PMID: 16543236] (WB, Human)
• Pore, N et al. EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms. Can Res 66: 3197-3204. 2006-01-01 [PMID: 16540671] (IP, Human)
• Lee, KS et al. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) reduces vascular endothelial growth factor expression in allergen-induced airway inflammation. Mol Pharmacol;69(6):1829-39. 2006-06-01 [PMID: 16527906] (WB, Mouse)
• Tian YM, Mole DR, Ratcliffe PJ, Gleadle JM. Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation. Biochem J 2006-07-01 [PMID: 16509823] (WB)
• Hui, A S et al. Calcium signaling stimulates translation of HIF-alpha during hypoxia. J. Biol. Chem. 20: 466-475. 2006-01-01 [PMID: 16507764] (WB, Rat, Human)
• Luo, Y et al. A constitutively active hypoxia-inducible factor-1alpha/VP16 hybrid factor activates expression of the human B-type natriuretic peptide gene. Molec. Pharmac. 69: 1953-1962. 2006-01-01 [PMID: 16507742] (GS, Human)
• Hsu T, Adereth Y, Kose N et al. Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility. J Biol Chem;281(17):12069-80. 2006-04-28 [PMID: 16505488] (WB, Human)
• Zhang W, Petrovic JM, Callaghan D et al. Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures. J Neuroimmunol 2006-05-01 [PMID: 16504308] (ELISA)
• Oda, T et al. Activation of hypoxia-inducible factor 1 during macrophage differentiation. Am. J. Physiol. Cell Physiol. 291: C104-113. 2006-01-01 [PMID: 16481368] (WB, Human)
• Trentin, D et al. Peptide-matrix-mediated gene transfer of an oxygen-insensitive hypoxia-inducible factor-1alpha variant for local induction of angiogenesis. Proc Natl Acad Sci U S A;103(8):2506-11. 2006-02-21 [PMID: 16477043] (WB, Human)
• Galabova-Kovacs, G et al. Essential role of B-Raf in ERK activation during extraembryonic development. PNAS. 103: 1325-1330. 2006-01-01 [PMID: 16432225] (IP, Mouse)
• Higami, Y et al. Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue. J. Nutrition. 136: 343-352. 2006-01-01 [PMID: 16424110] (IF/IHC, Mouse)
• Quintero, M et al. Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation.. Can. Res. 66: 770-774. 2006-01-01 [PMID: 16424008] (IF/IHC, Human)
• Villanueva, S et al. Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins. J. Physiol. Regul. Comp. Physiol. 290: R861-870. 2006-01-01 [PMID: 16284088] (IF/IHC, WB, Rat)
• Rodriguez-Porcel, M et al. Functional and structural remodeling of the myocardial microvasculature in early experimental hypertension. Am. J. Physiol. Heart Circ. Physiol. 290: H978-984. 2006-01-01 [PMID: 16214846] (WB, Porcine)
• Wang, J et al. Cardiomyopathy associated with microcirculation dysfunction in laminin alpha4 chain-deficient mice.. J. Biol. Chem. 281: 213-220. 2006-01-01 [PMID: 16204254] (ICC/IF, Mouse)
• Kong D, Park EJ, Stephen AG et al. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 65(19):9047-55. 2005-10-01 [PMID: 16204079] (EMSA, Human)
• Liu W, Guo M, Xu YB et al. Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia. 107(2):698-707. 2006-01-15 [PMID: 16166593] (WB, Mouse)
• Kato H, Inoue T, Asanoma K et al. Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1. Int J Cancer 2006-03-01 [PMID: 16161047]
• Hayashi M, Sakata M, Takeda T et al. Up-regulation of c-met protooncogene product expression through hypoxia-inducible factor-1alpha is involved in trophoblast invasion under low-oxygen tension. Endocrinology 2005-11-01 [PMID: 16099863] (Chemotaxis, Human)
• Behan A, Doyle S, Farrell M. Adaptive responses to mitochondrial dysfunction in the rho degrees Namalwa cell. Mitochondrion 2005-06-01 [PMID: 16050983] (WB, Human)
• Zagzag D, Krishnamachary B, Yee H et al. Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Cancer Res 2005-07-15 [PMID: 16024619] (WB, IF/IHC, Human)
• Maltepe E, Krampitz GW, Okazaki KM et al. Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Development 2005-08-01 [PMID: 15987772] (WB, Mouse)
• Alberghini A, Recalcati S, Tacchini L et al. Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells. J Biol Chem. 280(34):30120-8. 2005-08-26 [PMID: 15985433] (WB, Human)
• Kim SJ, Rabbani ZN, Dewhirst MW et al. Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer. Lung Cancer 2005-09-01 [PMID: 15935515] (IF/IHC, Human)
• Wang, B, Zou, Y, Li, H et al. Genistein Inhibited Retinal Neovascularization Expression of Vascular Endothelial Growth Factor Hypoxia Inducible Factor 1 alpha in a Mouse Model of Oxygen-Induced Retinopathy. J. of Ocular Pharmacology Therapeutics.:107-113. 2005-04-01 [PMID: 15857276] (Mouse)
• Li YM, Zhou BP, Deng J et al. A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells. Cancer Res 2005-04-15 [PMID: 15833858]
• Kazi AA, Jones JM, Koos RD. Chromatin immunoprecipitation analysis of gene expression in the rat uterus in vivo: estrogen-induced recruitment of both estrogen receptor alpha and hypoxia-inducible factor 1 to the vascular endothelial growth factor promoter. Mol Endocrinol 2005-08-01 [PMID: 15774498] (WB)
• Matsuyama T, Nakanishi K, Hayashi T et al. Expression of hypoxia-inducible factor-1alpha in esophageal squamous cell carcinoma. Cancer Sci 2005-03-01 [PMID: 15771621]
• Irie N, Matsuo T, Nagata I. Protocol of radiotherapy for glioblastoma according to the expression of HIF-1. Brain Tumor Pathol 2004-01-01 [PMID: 15696961] (IF/IHC, Human)
• Aminova LR, Chavez JC, Lee J et al. Prosurvival prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line. J Biol Chem. 280(5):3996-4003. 2005-02-04 [PMID: 15557337] (WB, Mouse)
• Knies-Bamforth, UE et al. c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism. Can. Res. 64:6563-6570. 2004-01-01 [PMID: 15374969] (WB, Rat)
• Tezel G, Wax MB. Hypoxia-inducible factor 1alpha in the glaucomatous retina and optic nerve head. Arch Ophthalmol 2004-09-01 [PMID: 15364715] (IHC-P, Human)
• Swinson DE, Jones JL, Cox G et al. Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways. Int J Cancer 2004-08-10 [PMID: 15185341] (IP, Human)
• Mansfield KD, Simon MC, Keith B. Hypoxic reduction in cellular glutathione levels requires mitochondrial reactive oxygen species. J Appl Physiol (1985) 2004-10-01 [PMID: 15180977] (WB, Human)
• Nishi H, Nakada T, Hokamura M et al. Hypoxia-inducible factor-1 transactivates transforming growth factor-beta3 in trophoblast. Endocrinology 2004-09-01 [PMID: 15155569] (WB, Human)
• Tissot van Patot MC, Bendrick-Peart J, Beckey VE et al. Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 2004-09-01 [PMID: 15132953] (WB, Human)
• Reichner JS, Albina JE. Determination of the role of hypoxia-inducible factor 1 in wound healing. Methods Enzymol 2004-01-01 [PMID: 15063696] (Rat)
• Pascual O, Roux JC, Soulage C et al. Carotid chemodenervation approach to study oxygen sensing in brain stem catecholaminergic cells. Methods Enzymol 2004-01-01 [PMID: 15063691] (IF/IHC, Rat)
• Yatabe N, Kyo S, Maida Y et al. HIF-1-mediated activation of telomerase in cervical cancer cells. Oncogene 2004-04-29 [PMID: 15048086] (Chemotaxis, Human)
• Wykoff CC, Sotiriou C, Cockman ME et al. Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene. Br J Cancer 2004-03-22 [PMID: 15026807] (Human)
• Erler JT, Cawthorne CJ, Williams KJ et al. Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and-independent mechanisms and contributes to drug Mol Cell Biol. 2004-04-01 [PMID: 15024076] (WB, Mouse, Human)
• Palladino MA, Powell JD, Korah N, Hermo L. Expression and localization of hypoxia-inducible factor-1 subunits in the adult rat epididymis. Biol Reprod 2004-04-01 [PMID: 14668208] (WB, Rat)
• Hu CJ, Wang LY, Chodosh LA et al. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol 2003-12-01 [PMID: 14645546] (WB)
• Imai T, Horiuchi A et al. Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. Am J Pathol 2003-01-10 [PMID: 14507651] (IF/IHC, Human)
• Liu MY, Poellinger L, Walker CL. Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene. Cancer Res 2003-05-15 [PMID: 12750296] (Rat)
• Park, J et al. Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1alpha in gastric cancer cells. Clin. Can. Res. 9:433-440. 2003-01-01 [PMID: 12538497] (WB, Human)
• Ivan, M et al. Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. PNAS. 99: 13459-13464. 2002-01-01 [PMID: 12351678] (WB, Human)
• Des Tombe AL, Van Beek-Harmsen BJ, Lee-De Groot MB, Van Der Laarse WJ. Calibrated histochemistry applied to oxygen supply and demand in hypertrophied rat myocardium. Microsc Res Tech 2002-09-01 [PMID: 12226811] (IF/IHC, Rat)
• Powell JD, Elshtein R, Forest DJ, Palladino MA. Stimulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) protein in the adult rat testis following ischemic injury occurs without an increase in HIF-1alpha messenger RNA expression. Biol Reprod 2002-09-01 [PMID: 12193413] (WB, Rat)
• Schindl M, Schoppmann SF, Samonigg H et al. Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer. Clin. Can. Res. 8: 1831-1837. 2002-01-01 [PMID: 12060624] (IHC-P, ICC/IF, Human)
• Ivan, M et al. Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. Science; 292(5516): 464-8. 2001-01-01 [PMID: 12004076] (IP)
• Shoshani T, Faerman A, Mett I et al. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol Cell Biol 2002-04-01 [PMID: 11884613] (EMSA)
• Pascual O, Denavit-Saubie M, Dumas S et al. Selective cardiorespiratory and catecholaminergic areas express the hypoxia-inducible factor-1alpha (HIF-1alpha) under in vivo hypoxia in rat brainstem. Eur J Neurosci 2001-12-01 [PMID: 11860493] (ICC/IF, Rat)
• Arsham AM, Plas DR, Thompson CB, Simon MC. Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. J Biol Chem 2002-04-26 [PMID: 11859074] (WB)
• Stokes DG, Liu G, Coimbra IB et al. Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysis Arthritis Rheum 2002-02-13 [PMID: 11840443] (WB, Bovine)
• Albina JE, Mastrofrancesco B, Vessella JA et al. HIF-1 expression in healing wounds: HIF-1alpha induction in primary inflammatory cells by TNF-alpha. Am J Physiol Cell Physiol 2001-12-01 [PMID: 11698256] (Rat)
• Kurebayashi J, Otsuki T, Moriya T et al. Hypoxia reduces hormone responsiveness of human breast cancer cells. Jpn J Cancer Res 2001-10-01 [PMID: 11676860] (IHC-P, Human)
• Duyndam, MCA et al. Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite. J Biol Chem;276(51):48066-76. 2001-12-21 [PMID: 11641398] (WB, Human)
• Schindl M, Oberhuber G, Pichlbauer EG et al. DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance. Int J Oncol 2001-10-01 [PMID: 11562758] (Human)
• Birner P, Gatterbauer B, Oberhuber G et al. Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis on neoangiogenesis. Cancer;92(1):165-71. 2001-07-01 [PMID: 11443623] (IHC-P, Human)
• Birner P, Schindl M, Obermair A et al. Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy. Clin Cancer Res 2001-06-01 [PMID: 11410504] (IF/IHC, Human)
• Ivan M, Kondo K, Yang H et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 2001-04-20 [PMID: 11292862]
• Jaakkola P, Mole DR, Tian YM et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001-04-20 [PMID: 11292861] (Human)
• Birner P, Schindl M, Obermair A et al. Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res;60(17):4693-6. 2000-09-01 [PMID: 10987269] (IHC-P, Human)
• Kondrashina, A. A Phosphorescent Nanoparticle-Based Probe for Sensing and Imaging of (Intra)Cellular Oxygen in Multiple Detection Modalities Adv Funct Mater 2012-01-01 (ICC/IF, Rat)
• Weaver J, Casellini C, Parson H, Vinik A. EXPRESSION OF HIF-1a IN A PANCREATIC DUCTAL ADENOCARCINOMA IN A PATIENT WITH NEWLY DIAGNOSED TYPE 2 DIABETES AACE Clinical Case Reports 2018-05-01
• Barbosa DM Effect of the rhubarb anthraquinone Rhein on cardiac fibroblast to myofibroblast transition Thesis
• Tran MGB, Bibby BAS, Yang L et al. Independence of HIF1a and androgen signaling pathways in prostate cancer bioRxiv (IF/IHC, Human)
• Kamura, T et al. Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. PNAS 97: 10430-10435. 2000-01-01 [PMID: 10973499] (WB, IP)
• Maugeri G The role of VIP family members in diabetic retinopathy Thesis (ICC/IF, IB, Rat)
• Bagchi R, Bagchi A, Salunke A et al. Chemical hypoxia in human pluripotent NT2 stem cell-derived neurons: Effect of hydroxamic acid and benzamide-based epigenetic drugs Neurosci Res Notes 2019-08-22 (ELISA, Human)
• Toth RK, Tran JD, Muldong MT et al. Hypoxia-Induced PIM Kinase and Laminin-Activated Integrin alpha 6 Mediate Resistance to PI3K Inhibitors in Bone-Metastatic CRPC bioRxiv (IF/IHC, Human, Mouse)
• Wang G, Hazra TK, Mitra S et al. Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells. Nucleic Acids Res 2000-05-15 [PMID: 10773083] (WB)
• Fujimoto TN, Colbert LE, Molkentine JM, Baseler L. EGLN Inhibition Reduces Gastrointestinal Radiation Toxicity and Improves Survival in a Murine Model of Locally Advanced Pancreatic Cancer bioRxiv 2018-07-20 (WB, Mouse)
• Guo J, Zhou Q, Huang W et al. CDCA8 promotes bladder cancer survival by stabilizing HIF1? expression under hypoxic Research Square 2023-05-03
• Sutter, CH et al. Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. PNAS. 97: 4748-4753. 2000-01-01 [PMID: 10758161] (WB, Human)
• Gothie, E et al. Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha. J. Biol. Chem. 275(10):6922-6927. 2000-01-01 [PMID: 10702253] (WB, Human)
• Zhong, H et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Can. Res.1999; 59: 5830-5835. 1999-01-01 [PMID: 10582706] (IHC-P, Mouse, Human)
• Vorrink SU. Regulatory crosstalk and interference between the PCB 126 stimulated AHR and hypoxia stimulated HIF-1a signaling pathways. 2014-01-01 (IHC-P, Rat)
  
  Details:
  Mouse monoclonal anti-HIF-1 alpha antibody used for IHC on paraffin-embedded livers from untreated and PCB 126 treated rats at a dilution of 1:50, incubated for 2 hours at room temperature (Figure 3-1)
• Li H. Role of the p53/miR-34a pathway in the response to tumor hypoxia Thesis 2017-01-01 (WB, Chemotaxis)
• Robinson T. Targeting cFLIP to Inhibit Residual Cancer Stem Cells after Chemotherapy. Thesis 2017-01-01 (WB)
• Palladino MA, Powell JD, Korah N et al. Expresion Localization of Hypoxia-Inducible Factor-1 Subunits in the Adult Rat Epididymis. Biol Reprod. 70(4):1121-30. 2004-04-01 [PMID: 1466820]

Reviews for HIF-1 alpha Antibody (NB100-105) (44)

Average Rating: 4.2

(Based on 44 reviews)

We have 44 reviews tested in 5 species: Human, Mouse, Rat, Other, 0.

Images	Ratings	Applications	Species	Date	Details
	reviewed by: Sarah Miller	IHC-P	Human	01/19/2022	Summary Application Immunohistochemistry-Paraffin Sample Tested Throat cancer tissue Species Human Lot H1alpha67 Comments Comments PFA fixed paraffin-embedded sections. Primary antibody dilution 1:100.
	reviewed by: Toni johanson	WB	Human	03/31/2021	Summary Application Western Blot Sample Tested Caki-1 cell lysate,fibroblasts Species Human Lot BQ
	reviewed by: Betty Poon	WB	Human	08/09/2020	Summary Application Western Blot Sample Tested HEK293A whole cell lysate,RCC4 Whole cell lysate Species Human Lot BH-23
	reviewed by: Rajnish Singh	WB	Human	06/13/2019	Summary Application Western Blot Sample Tested Blood mononuclear cells (PBMCs) Species Human Lot BH-13 Comments Comments Confirmation of induction of hypoxia in CoCl2 treated PBMCs infected with vGPCR frame shift knock out and wild type revertant KSHV virion. KSHV infected cells were treated with CoCl2 for 48 hours followed by protein isolation and western blot against HIF1 alpha .
	reviewed by: Marie Lassont	WB	Human	02/02/2019	Summary Application Western Blot Sample Tested Human cancer cell whole cell lysate Species Human Lot AB6
	reviewed by: Steve Rey	WB	Rat	02/02/2019	Summary Application Western Blot Sample Tested Rat liver Species Rat Lot AW1
	reviewed by: Anthony Morales	WB	Human	01/29/2019	Summary Application Western Blot Sample Tested human adrenal cancer cells (whole cell lysate) Species Human Lot unknown
	reviewed by: Arthur Von Houtt	WB	Rat	01/29/2019	Summary Application Western Blot Sample Tested Rat liver Species Rat Lot AW-1 Comments Comments Detection Method: ECL
	reviewed by: Arthur Von Houtt	WB	Human	01/24/2019	Summary Application Western Blot Sample Tested Hela whole cell lysate Species Human Lot AB7 Comments Comments ECL solution for 5min, then exposure to film 3-5min
	reviewed by: David White	WB	Human	01/23/2019	Summary Application Western Blot Sample Tested 293t cell lysate Species Human Lot NB100-105
	reviewed by: Jun Hamazaki	WB	Human	06/29/2017	Summary Application Western Blot Sample Tested 293t cell lysate Species Human Lot bh-1
	reviewed by: Lauren Zenewicz	WB	Mouse	02/01/2017	Summary Application Western Blot Sample Tested CD4 T cells cultured in vitro, stimulated with anti-CD3/anti-CD28 Species Mouse Comments Comments Figure Legend: Naïve CD4 T cells from WT, VHL-deficient (Vhl KO), or HIF-1a–deficient (Hif1a KO) mice were differentiated under IL-22–skewing conditions for a total of 60 h. Some cells remained at normoxia for the duration of the culture (N); others were at normoxia for 35 h and then hypoxia (1% O2) for 24 h (H). At 60 h, nuclear extracts were harvested, and HIF-1a and lamin B1 levels were analyzed by Western blot.
	reviewed by: Verified Customer	WB	Mouse	08/17/2016	Summary Application Western Blot Sample Tested HL-1 cardiomyocytes Species Mouse
	reviewed by: MENG xing	WB	Human	05/08/2016	Summary Application Western Blot Sample Tested k562 cells Species Human Lot BA-3
	reviewed by: Betty Poon	WB	Human	04/18/2016	Summary Application Western Blot Sample Tested HEK293A whole cell lysate Species Human Lot AW-1
	reviewed by: Verified Customer	WB	Mouse	03/24/2016	Summary Application Western Blot Species Mouse Lot BD-10
	reviewed by: Amruta Ashtekar	WB	Mouse	10/07/2015	Summary Application Western Blot Sample Tested Cell lysate Species Mouse
	reviewed by: Verified Customer	WB	Mouse	10/05/2015	Summary Application Western Blot Sample Tested mouse retina Species Mouse Lot NB100-479
	reviewed by: Haiquan Lu	WB	Human	08/23/2015	Summary Application Western Blot Sample Tested Human cancer cell whole cell lysate Species Human
	reviewed by: Lakshmi Reddy Bollu	WB	Human	08/10/2015	Summary Application Western Blot Sample Tested Human prostate cancer cell line protein samples Species Human
	reviewed by: Liyong Zhang	WB	Human	04/28/2015	Summary Application Western Blot Species Human
	reviewed by: cynthia morimoto	WB	Mouse	12/17/2014	Summary Application Western Blot Sample Tested See PIMD: 23148210 Species Mouse
	reviewed by: Verified Customer	WB	Human	07/18/2014	Summary Application Western Blot Sample Tested Caki-1 cell lysate Species Human
	reviewed by: Aparna Akolkar	WB	Human	07/01/2014	Summary Application Western Blot Sample Tested Hela Cell Lysate Species Human
	reviewed by: Verified Customer	WB	Human	05/09/2014	Summary Application Western Blot Sample Tested Hela whole cell lysate Species Human
	reviewed by: Cidi Chen	WB	Mouse	04/28/2014	Summary Application Western Blot Sample Tested mouse brain lysate Species Mouse
	reviewed by: Verified Customer	WB	Mouse	04/28/2014	Summary Application Western Blot Sample Tested Mouse Species Mouse
	reviewed by: Verified Customer	IHC	Other	04/14/2014	Summary Application Immunohistochemistry Species Other
	reviewed by: Verified Customer	IF	Other	04/14/2014	Summary Application Immunofluorescence Species Other
	reviewed by: Verified Customer	WB	Mouse	03/28/2014	Summary Application Western Blot Species Mouse
	reviewed by: Verified Customer	WB	Human	08/23/2012	Summary Application Western Blot Sample Tested Whole cell lysate Species Human Lot AB7
	reviewed by: KAMESWARAN RAVICHANDRAN	IF	Rat	08/22/2012	Summary Application Immunofluorescence Sample Tested RAT KIDNEY Species Rat Lot F2