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Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in the oxygen level in the cellular environment. The transcriptional complex plays a role in mammalian oxygen homeostasis and is comprised of an alpha-beta heterodimer. HIF-1 beta is a constitutive nuclear protein that dimerizes with oxygen-regulated HIF-1 alpha subunits.

HIF-1 alpha

HIF-2 alpha

HIF-3 alpha