HIF-2 alpha/EPAS1 Antibody (ep190b) [Biotin] Summary
Human HIF-2 alpha, corresponding to amino acids 535-631. [UniProt# Q99814]
This is specific for HIF-2 alpha and does not cross-react with HIF-1 alpha.
Protein G purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C in the dark.
Biotin (A=N/A, E=N/A)
0.05% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
Protein G purified
This HIF-2 alpha (ep190b) antibody is useful for ELISA, Flow Cytometry, Immunohistochemistry on paraffin-embedded sections and Western Blot. In WB, it recognizes a band at ~118 kDa representing HIF-2 alpha. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Ability to use in mouse is mixed with some positive and some negative results.
Alternate Names for HIF-2 alpha/EPAS1 Antibody (ep190b) [Biotin]
- Basic-helix-loop-helix-PAS protein MOP2
- Class E basic helix-loop-helix protein 73
- endothelial PAS domain protein 1
- endothelial PAS domain-containing protein 1
- HIF-1alpha-like factor
- HIF2 alpha
- HIF-2 alpha
- hif2a angiogenesis
- HLFHIF-1-alpha-like factor
- hypoxia-inducible factor 2 alpha
- Hypoxia-inducible factor 2-alpha
- Member of PAS protein 2
- PASD2PAS domain-containing protein 2
Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-2 alpha is predominantly expressed in highly vascularized tissues of adult humans and endothelial cells of the embryonic and adult mouse, whereas HIF-1 alpha functions primarily in extravascular tissues. HIF-2 alpha is also a potent activator of the tie-2 gene, which is known to be selectively expressed in endothelial cells.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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