Species: Hu, Mu, Rt, Bv
Applications: WB, Flow, IB, ICC/IF, IHC, IHC-P, IP, Dual ISH-IHC, Single-Cell Western
Host: Rabbit Polyclonal
Species: Hu, Rt
Applications: WB, Flow, ICC/IF, IHC-P, PEP-ELISA, Ctrl, ICC/IF
Host: Goat Polyclonal
Species: Hu, Mu
Applications: WB, Flow
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Species: Hu
Applications: WB, ELISA, PA, AP
Description
Forkhead box P3 (FoxP3), aka Scurfin and JM2, is a protein involving in immune system responses and functioning as a transcriptional regulator crucial in the development and inhibitory of regulatory T-Cells (Treg). FoxP3 is a master regulator of the Treg lineage, who requires Ahr and STAT-5 and other additional transcription factors to retains its complete function and differentiation. Scurfin remains steady and constitutively expressed in two conditions: a high level in CD25 + CD4 positive regulatory T cells and a low level in CD4 positive/CD25 negative cells. JM2 is absent in CD4 negative/CD8 positive T cells. FoxP3 defects are related to various cancers and autoimmune diseases, and X-linked syndrome (IPEX), while overexpression may also cause severe immunodeficiency.
Bioinformatics
Entrez |
Mouse Rat Human |
Uniprot |
Human Human Human Human Human Mouse Mouse Human |
Product By Gene ID |
50943 |
Alternate Names |
- AIID
- AIIDMGC141961
- DIETER
- forkhead box P3
- Forkhead Box Protein P3
- FOXP3delta7
- immune dysregulation, polyendocrinopathy, enteropathy, X-linked
- Immunodeficiency, Polyendocrinopathy, Enteropathy, X-Linked
- IPEX
- JM2
- MGC141961
- MGC141963
- PIDX
- PIDXMGC141963
- scurfin
- SCURFIN
- Scurfin
- XPID
- XPIDpolyendocrinopathy, enteropathy, X-linked
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Bioinformatics Tool for FoxP3
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Related FoxP3 Blog Posts
Check out the latest blog posts on FoxP3.
FOXP3
Is has been established that the regulatory transcription factor FOXP3 (a member of the forkhead/winged-helix family of transcription factors) is imperative to immune system homeostasis through CD4+CD25+ regulatory T cell function. Distinctively, ... Read more.
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Meeting Report: 2nd International Antibody Validation Meeting
Bio-Techne brands Novus Biologicals® and R&D Systems® were proud to support the 2nd International Antibody Validation Meeting held at Bath University, on the 15-16 September, 2016. Almost 100 participants from around the world, including funde... Read more.
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FOXP3: Master Regulatory Transcriptional Factor
FOXP3, a forkhead family transcription factor specially expressed in regulatory T (Treg) cells, controls the expression of many key immune-regulatory genes. Treg cells are a population of T lymphocytes that have critical roles in the immune system hom... Read more.
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FOXP3 is a Master Regulator of T Regulatory (Treg) Cells
FOXP3, a member of forkhead/winged-helix family of transcription factors acts as a "master" regulator for the development and suppressive function of regulatory T cells (Tregs). Its constitutive expression is necessary for the suppressive function of ... Read more.
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Read more FoxP3 related blogs.