Antibodies, Kits, Proteins and Research Reagents
Chemokines are small proteins involved in the inflammatory response. They are a type of cytokine that attract leukocytes to infection sites by acting as chemoattractants. Chemokines interact with the targeted leukocyte via GPCRs. Chemokines are divided into two major subfamilies, which are defined based on their pairs of cysteine residues. CC chemokines contain adjacent cysteine resides, whereas CXC chemokines’ cysteines are separated by a different amino acid. Cytokines are signaling proteins produced by various cells (primarily leukocytes) for use in cellular communication in order to regulate immunity, inflammation and hematopoiesis. Cytokines act via binding membrane receptors, which then activate second messengers in order to alter gene expression.