iNOS Products

Antibodies
iNOS Antibody (K13-A)
iNOS Antibody (K13-A)
NBP1-33780
Species: Hu, Mu, Rt, Po
Applications: WB, ELISA, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Host: Rabbit Monoclonal
Lysates
iNOS Knockout HeLa Cell Lysat ...
iNOS Knockout HeLa Cell Lysate
NBP2-65101
Species: Hu
Applications: WB
iNOS Overexpression Lysate
iNOS Overexpression Lysate
NBL1-13721
Species: Hu
Applications: WB
Proteins
Recombinant Human iNOS Protei ...
Recombinant Human iNOS Protein
H00004843-Q01
Species: Hu
Applications: WB, ELISA, PA, AP

Description

Nitric oxide (NO) is an inorganic, gaseous free radical that carries a variety of messages between cells. Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO. NO production is mediated by members of the nitric oxide synthase (NOS) family. NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) & endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. All NOS isoforms contain calmodulin, nicotinamide adenine dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), and flavin mononucleotide (FMN) binding domains.eNOS synthesizes NO in vascular endothelial cells where it appears to play an important role in the control of vasotension and platelet aggregation. eNOS and bNOS share ~50% sequence homology, and their activity depends on binding to the calcium/calmodulin complex. Both constitutive isoforms respond immediately to increased levels of calcium to produce low levels of NO over a short period of time.

Bioinformatics

Entrez Human
Mouse
Rat
Bovine
Uniprot Human
Human
Mouse
Product By Gene ID 4843
Alternate Names
  • NOS, type II
  • Inducible NO synthase
  • nitric oxide synthase, macrophage
  • Hepatocyte NOS
  • nitric oxide synthase, inducible
  • iNOS
  • INOS
  • nitric oxide synthase 2A (inducible, hepatocytes)
  • EC 1.14.13.39
  • NOS
  • NOS2ANOS type II
  • HEP-NOSPeptidyl-cysteine S-nitrosylase NOS2
  • Inducible NOS
  • nitric oxide synthase 2, inducible

Research Areas for iNOS

Find related products by research area and learn more about each of the different research areas below.

Cancer
HIF Target Genes
Hypoxia
Neuroscience
Neurotransmission

Bioinformatics Tool for iNOS

Discover related pathways, diseases and genes to iNOS. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related iNOS Blog Posts

Check out the latest blog posts on iNOS.
Toll-like receptors in the intestinal epithelial cells
By Jamshed Arslan, Pharm. D., PhD. Toll-like receptors (TLRs) are microbe-sensing proteins that act as first responders to danger signals. TLRs help the intestinal epithelial cells (IECs) recognize commensal bacteria...    Read more.
The effects of curcumin on IKB Alpha and the NFkB signaling pathway
The IKK complex, or inhibitor of NFkB kinase, is composed of IKK alpha and IKK beta.  These kinases are at the core of the NFkB signaling cascade.  The NFkB family is made up of transcription factors that are kept inactive in the cytoplasm through...    Read more.
iNOS: The Nitric Oxide Boss
Nitric oxide (NO) is an inorganic, gaseous, and reactive free radical that acts as a biologic mediator in processes such as neurotransmission, vasorelaxation, and cytotoxicity. In addition, it has antimicrobial and anti-tumoral activities. NO producti...    Read more.
Read more iNOS related blogs.