Hu, Mu, Rt, Po, Av, Fe, Fi, Rb, XpApplications:
WB, ICC/IF, IHC, IHC-PHost:
WB, ELISA, Flow, IHC-PHost:
WB, ELISA, PA
Nitric oxide (NO) is an inorganic, gaseous free radical that carries a variety of messages between cells. Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO. NO production is mediated by members of the nitric oxide synthase (NOS) family. NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) & endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. All NOS isoforms contain calmodulin, nicotinamide adenine dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), and flavin mononucleotide (FMN) binding domains.eNOS synthesizes NO in vascular endothelial cells where it appears to play an important role in the control of vasotension and platelet aggregation. eNOS and bNOS share ~50% sequence homology, and their activity depends on binding to the calcium/calmodulin complex. Both constitutive isoforms respond immediately to increased levels of calcium to produce low levels of NO over a short period of time.
|Product By Gene ID
- NOS, type II
- Inducible NO synthase
- nitric oxide synthase, macrophage
- Hepatocyte NOS
- nitric oxide synthase, inducible
- nitric oxide synthase 2A (inducible, hepatocytes)
- EC 220.127.116.11
- NOS2ANOS type II
- HEP-NOSPeptidyl-cysteine S-nitrosylase NOS2
- Inducible NOS
- nitric oxide synthase 2, inducible
Bioinformatics Tool for iNOS
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|iNOS: The Nitric Oxide Boss
Nitric oxide (NO) is an inorganic, gaseous, and reactive free radical that acts as a biologic mediator in processes such as neurotransmission, vasorelaxation, and cytotoxicity. In addition, it has antimicrobial and anti-tumoral activities. NO producti... Read more.