Recombinant Human TNF-alpha Protein

Recombinant Human TNF-alpha (Catalog # 210-TA) has a molecular weight (MW) of 53.1 kDa as analyzed by SEC-MALS, suggesting that this protein is a homotrimer. MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation).

Recombinant Human TNF-alpha (Catalog # 210‑TA) induces cytotoxicity in the L-929 mouse fibroblast cell line in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is 25‑100 pg/mL.

1 µg/lane of Recombinant Human TNF-alpha was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa.

• Reactivity: Hu
• Applications: Bioactivity

Recombinant Human TNF-alpha Protein Summary

• Additional Information: Analyzed by SEC-MALS. A new economically priced TNF-alpha is available! The new protein is HEK293 expressed!
• Details of Functionality: Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. Matthews, N. and M.L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 221. The ED₅₀ for this effect is 25-100 pg/mL.
• Source: E. coli-derived human TNF-alpha protein
  Val77-Leu233, with and without an N-terminal Met
• Accession #: P01375
• N-terminal Sequence: Met & Val77
• Protein/Peptide Type: Recombinant Proteins
• Gene: TNF
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 17 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 17 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 0.1-1 mg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human TNF-alpha Protein

• APC1 protein
• Cachectin
• Cachetin
• DIF
• TNF
• TNF, monocyte-derived
• TNFA
• TNF-A
• TNFalpha
• TNF-alpha
• TNF-alphacachectin
• TNFATNF, macrophage-derived
• TNFG1F
• TNFSF1A
• TNFSF2
• TNFSF2TNF superfamily, member 2
• tumor necrosis factor (TNF superfamily, member 2)
• tumor necrosis factor alpha
• Tumor necrosis factor ligand superfamily member 2
• tumor necrosis factor
• tumor necrosis factor-alpha

Background

Tumor necrosis factor alpha (TNF-alpha ), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism (1, 2). Human TNF-alpha consisits of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 177 aa extracellular domain (ECD) (3). Within the ECD, human TNF-alpha shares 97% aa sequence identity with rhesus and 71%-92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-alpha . TNF-alpha is produced by a wide variety of immune, epithelial, endothelial, and tumor cells (1, 2). TNF-alpha is assembled intracellularly to form a noncovalently linked homotrimer which is expressed on the cell surface (4). Cell surface TNF-alpha can induce the lysis of neighboring tumor cells and virus infected cells, and it can generate its own downstream cell signaling following ligation by soluble TNFR I (2, 5). Shedding of membrane bound TNF-alpha by TACE/ADAM17 releases the bioactive cytokine, a 55 kDa soluble trimer of the TNF-alpha extracellular domain (6-8). TNF-alpha binds the ubiquitous 55-60 kDa TNF RI (9, 10) and the hematopoietic cell-restricted 80 kDa TNF RII (11, 12), both of which are also expressed as homotrimers (1, 2, 13). Both type I and type II receptors bind TNF-alpha with comparable affinity (14), although only TNF RI contains a cytoplasmic death domain which triggers the activation of apoptosis. Soluble forms of both types of receptors are released and can neutralize the biological activity of TNF-alpha (15).

1. Zelova, H. and J. Hosek (2013) Inflamm. Res. 62:641.
2. Juhasz, K. et al. (2013) Expert Rev. Clin. Immunol. 9:335.
3. Pennica, D. et al. (1984) Nature 312:724.
4. Tang, P. et al. (1996) Biochemistry 35:8216.
5. Perez, C. et al. (1990) Cell 63:251.
6. Black, R.A. et al. (1997) Nature 385:729.
7. Moss, M.L. et al. (1997) Nature 385:733.
8. Gearing, A.J.H. et al. (1994) Nature 370:555.
9. Schall, T.J. et al. (1990) Cell 61:361.
10. Loetscher, H. et al. (1990) Cell 61:351.
11. Dembic, Z. et al. (1990) Cytokine 2:231.
12. Smith, C.A. et al. (1990) Science 248:1019.
13. Loetscher, H. et al. (1991) J. Biol. Chem. 266:18324.
14. Pinckard, J.K. et al. (1997) J. Biol. Chem. 272:10784.
15. Engelmann, H. et al. (1990) J. Biol. Chem. 265:1531.

Publications for TNF-alpha (210-TA)(749)

Publications using 210-TA	Applications	Species
P Dörschmann, C Seeba, T Thalenhors, J Roider, A Klettner Anti-inflammatory properties of antiangiogenic fucoidan in retinal pigment epithelium cells Heliyon, 2023;9(4):e15202. 2023 [PMID: 37123974] (Cell Culture, Porcine)	Cell Culture	Porcine
J Nassour, LG Aguiar, A Correia, TT Schmidt, L Mainz, S Przetocka, C Haggblom, N Tadepalle, A Williams, MN Shokhirev, SC Akincilar, V Tergaonkar, GS Shadel, J Karlseder Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis Nature, 2023;614(7949):767-773. 2023 [PMID: 36755096] (Bioassay, Human)	Bioassay	Human
H Ben Halima, N Zine, J Bausells, N Jaffrezic-, A Errachid A Novel Cortisol Immunosensor Based on a Hafnium Oxide/Silicon Structure for Heart Failure Diagnosis Micromachines, 2022;13(12):. 2022 [PMID: 36557534] (Bioassay, Human)	Bioassay	Human
D Cai, M Fraunfelde, SY Chen Blood serum analysis: A modified sandwich enzyme-linked immunosorbent assay protocol MethodsX, 2022;9(0):101923. 2022 [PMID: 36483291] (ELISA Control, Human)	ELISA Control	Human
HJ Kim, SH Kim, YS Oh, SR Lee, HD Chae Dienogest May Reduce Estradiol- and Inflammatory Cytokine-Induced Cell Viability and Proliferation and Inhibit the Pathogenesis of Endometriosis: A Cell Culture- and Mouse Model-Based Study Biomedicines, 2022;10(11):. 2022 [PMID: 36428561] (Cell Culture, Human)	Cell Culture	Human
K Li, Y Zhu, P Zhang, M Alini, S Grad, Z Li Anti-inflammatory and pro-anabolic effects of 5-aminosalicylic acid on human inflammatory osteoarthritis models Journal of Orthopaedic Translation, 2023;38(0):106-116. 2023 [PMID: 36381242] (Cell Culture, Human)	Cell Culture	Human
B Saravi, Z Li, V Basoli, S Grad, S Häckel, CE Albers, M Alini, H Schmal, P Obid, G Lang In Vitro Characterization of a Tissue Renin-Angiotensin System in Human Nucleus Pulposus Cells Cells, 2022;11(21):. 2022 [PMID: 36359814] (Bioassay, Human)	Bioassay	Human
DR Calabrese, T Tsao, M Magnen, C Valet, Y Gao, B Mallavia, JJ Tian, EA Aminian, KM Wang, A Shemesh, EB Punzalan, A Sarma, CS Calfee, SA Christenso, CR Langelier, SR Hays, JA Golden, LE Leard, ME Kleinhenz, NA Kolaitis, RJ Shah, A Venado, LL Lanier, JR Greenland, DM Sayah, A Ardehali, J Kukreja, SS Weigt, JA Belperio, JP Singer, MR Looney NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes JCI Insight, 2022;0(0):. 2022 [PMID: 36346670] (Bioassay, Human)	Bioassay	Human
S Hayashi, CK Muraleedha, M Oku, S Tomar, SP Hogan, M Quiros, CA Parkos, A Nusrat Intestinal epithelial BLT1 promotes mucosal repair JCI Insight, 2022;0(0):. 2022 [PMID: 36301666] (Bioassay, Human)	Bioassay	Human
Bhuyan S, Pal B, Pathak L, Saikia P, Mitra S, Gayan S, Mokhtari R, Li H, Ramana C, Baishya D, Das B Targeting hypoxia-induced tumor stemness by activating pathogen-induced stem cell niche defense. Front Immunol, 0;13(0):933329. 0 [PMID: 36248858] (Bioassay, Complex Species Category)	Bioassay	Complex Species Category
P Pavlidis, A Tsakmaki, A Treveil, K Li, D Cozzetto, F Yang, U Niazi, BH Hayee, M Saqi, J Friedman, T Korcsmaros, G Bewick, N Powell Cytokine responsive networks in human colonic epithelial organoids unveil a molecular classification of inflammatory bowel disease Cell Reports, 2022;40(13):111439. 2022 [PMID: 36170836] (Bioassay, Human)	Bioassay	Human
H Iwanishi, O Yamanaka, T Sumioka, S Yasuda, M Miyajima, S Saika Delayed regression of laser-induced choroidal neovascularization in TNFalpha-null mice Journal of Cellular and Molecular Medicine, 2022;0(0):. 2022 [PMID: 36127870] (Bioassay, Human)	Bioassay	Human
AA Hariri, SS Newman, S Tan, D Mamerow, AM Adams, N Maganzini, BL Zhong, M Eisenstein, AR Dunn, HT Soh Improved immunoassay sensitivity and specificity using single-molecule colocalization Nature Communications, 2022;13(1):5359. 2022 [PMID: 36097164] (Bioassay, Human)	Bioassay	Human
V Catalán, P Domench, J Gómez-Ambr, B Ramírez, S Becerril, A Mentxaka, A Rodríguez, V Valentí, R Moncada, J Baixauli, C Silva, J Escalada, G Frühbeck Dermatopontin Influences the Development of Obesity-Associated Colon Cancer by Changes in the Expression of Extracellular Matrix Proteins International Journal of Molecular Sciences, 2022;23(16):. 2022 [PMID: 36012487] (Stimulation, Human)	Stimulation	Human
DC Humphries, R Mills, C Boz, BJ McHugh, N Hirani, AG Rossi, A Pedersen, HT Schambye, RJ Slack, H Leffler, UJ Nilsson, W Wang, T Sethi, AC Mackinnon Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation Frontiers in Pharmacology, 2022;13(0):949264. 2022 [PMID: 36003515] (Bioassay, Human)	Bioassay	Human
YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells Science Advances, 2022;8(34):eabn5522. 2022 [PMID: 36001668] (Bioassay, Human)	Bioassay	Human
Z Cai, S Tian, T Klein, L Tu, LW Geenen, T Koudstaal, AE van den Bo, YB de Rijke, IKM Reiss, E Boersma, C van der Le, M Van Faasse, I Kema, DJ Duncker, KA Boomars, K Tran-Lundm, C Guignabert, D Merkus Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Ralpha Scientific Reports, 2022;12(1):12326. 2022 [PMID: 35853948] (Bioassay, Human)	Bioassay	Human
XJ Mi, JK Kim, S Lee, SK Moon, YJ Kim, H Kim In vitro assessment of the anti-inflammatory and skin-moisturizing effects of Filipendula palmata (Pall.) Maxim. On human keratinocytes and identification of its bioactive phytochemicals Journal of ethnopharmacology, 2022;296(0):115523. 2022 [PMID: 35809756] (Bioassay, Human)	Bioassay	Human
MD Gundersen, KB Larsen, KM Johnsen, R Goll, J Florholmen, G Haraldsen Hypo-osmotic stress induces the epithelial alarmin IL-33 in the colonic barrier of ulcerative colitis Scientific Reports, 2022;12(1):11550. 2022 [PMID: 35798804] (Bioassay, Human)	Bioassay	Human
CW Lee, YF Chen, AW Hsiao, AY Wang, OY Shen, BY Wang, LWC Ho, WT Lin, CHJ Choi, OK Lee Demystifying the long noncoding RNA landscape of small EVs derived from human mesenchymal stromal cells Journal of advanced research, 2022;39(0):73-88. 2022 [PMID: 35777918] (Bioassay, Human)	Bioassay	Human
E Iverson, K Griswold, D Song, TB Gagliardi, K Hamidzadeh, M Kesimer, S Sinha, M Perry, GA Duncan, MA Scull Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium MBio, 2022;0(0):e0105522. 2022 [PMID: 35699372] (Bioassay, Human)	Bioassay	Human
S Hong, EY Kim, SE Lim, JH Kim, Y Sohn, HS Jung Dendrobium nobile Lindley Administration Attenuates Atopic Dermatitis-like Lesions by Modulating Immune Cells International Journal of Molecular Sciences, 2022;23(8):. 2022 [PMID: 35457288] (Bioassay, Human)	Bioassay	Human
R Giri, EC Hoedt, S Khushi, AA Salim, AS Bergot, V Schreiber, R Thomas, MA McGuckin, TH Florin, M Morrison, RJ Capon, P Ó Cuív, J Begun Secreted NF-kappaB suppressive microbial metabolites modulate gut inflammation Cell Reports, 2022;39(2):110646. 2022 [PMID: 35417687] (Bioassay, Human)	Bioassay	Human
S Banjonjit, M Taweechoti, S Rungsiyano Effect of probiotic Lactobacillus paracasei on tumor necrosis factor-alpha level in gingival crevicular fluid of patients undergoing impacted third molar removal Journal of oral science, 2022;0(0):. 2022 [PMID: 35400713] (ELISA Standard, Human)	ELISA Standard	Human
P Sekhri, DK Ledezma, A Shukla, EE Sweeney, R Fernandes The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells Cancers, 2022;14(6):. 2022 [PMID: 35326601] (Cell Culture, Human)	Cell Culture	Human
CC Yang, LD Hsiao, YF Shih, HH Lin, CM Yang 5,8-Dihydroxy-4 ', 7-dimethoxyflavone Attenuates TNF-alpha-Induced Expression of Vascular Cell Adhesion Molecule-1 through EGFR/PKCalpha/PI3K/Akt/Sp1-Dependent Induction of Heme Oxygenase-1 in Human Cardiac Fibroblasts Oxidative Medicine and Cellular Longevity, 2022;2022(0):1372958. 2022 [PMID: 35281466] (Bioassay, Human)	Bioassay	Human
H Farese, Farese H, Noack M, M Noack, P Miossec Synoviocytes from pigmented villonodular synovitis are less sensitive to cadmium-induced cell death than synoviocytes from rheumatoid arthritis. Sci Rep, 0;12(1):3832. 0 [PMID: 35264617] (Bioassay, Human)	Bioassay	Human
D Stacey, L Chen, PJ Stanczyk, JMM Howson, AM Mason, S Burgess, S MacDonald, J Langdown, H McKinney, K Downes, N Farahi, JE Peters, S Basu, JS Pankow, W Tang, N Pankratz, M Sabater-Ll, PS de Vries, NL Smith, CHARGE Hem, AD Gelinas, DJ Schneider, N Janjic, NJ Samani, S Ye, C Summers, ER Chilvers, J Danesh, DS Paul Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus Nature Communications, 2022;13(1):1222. 2022 [PMID: 35264566] (Bioassay, Human)	Bioassay	Human
C Stene, A Röme, I Palmquist, C Linninge, G Molin, S Ahrné, LB Johnson, B Jeppsson Administration of probiotics to healthy volunteers: effects on reactivity of intestinal mucosa and systemic leukocytes BMC gastroenterology, 2022;22(1):100. 2022 [PMID: 35247974] (Cell Culture, Human)	Cell Culture	Human
C Ge, J Tan, D Lou, L Zhu, Z Zhong, X Dai, Y Sun, Q Kuang, J Zhao, L Wang, J Liu, B Wang, M Xu Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling Redox Biology, 2022;51(0):102274. 2022 [PMID: 35240537] (Bioassay, Human)	Bioassay	Human
K Harhouri, P Cau, F Casey, KM Guedenon, Y Doubaj, L Van Malder, G Mejia-Balt, C Bartoli, A De Sandre-, N Lévy MG132 Induces Progerin Clearance and Improves Disease Phenotypes in HGPS-like Patients' Cells Cells, 2022;11(4):. 2022 [PMID: 35203262] (Bioassay, Human)	Bioassay	Human
MA Shandell, AL Capatina, SM Lawrence, WJ Brackenbur, D Lagos Inhibition of the Na+/K+-ATPase by cardiac glycosides suppresses expression of the IDO1 immune checkpoint in cancer cells by reducing STAT1 activation The Journal of Biological Chemistry, 2022;0(0):101707. 2022 [PMID: 35150740] (Bioassay, Human)	Bioassay	Human
AM Abu El-Asr, A Ahmad, MI Nawaz, MM Siddiquei, A De Zutter, L Vanbrabant, PW Gikandi, G Opdenakker, S Struyf Tissue Inhibitor of Metalloproteinase-3 Ameliorates Diabetes-Induced Retinal Inflammation Frontiers in Physiology, 2021;12(0):807747. 2021 [PMID: 35082694] (Bioassay, Human)	Bioassay	Human
JJ Lenoir, JP Parisien, CM Horvath Immune regulator LGP2 targets Ubc13/UBE2N to mediate widespread interference with K63 polyubiquitination and NF-kappaB activation Cell Reports, 2021;37(13):110175. 2021 [PMID: 34965427] (Bioassay, Human)	Bioassay	Human
L Toma, T Barb?lat?, GM Sanda, LS Niculescu, AV Sima, CS Stancu CRISPR/dCas9 Transcriptional Activation of Endogenous Apolipoprotein AI and Paraoxonase 1 in Enterocytes Alleviates Endothelial Cell Dysfunction Biomolecules, 2021;11(12):. 2021 [PMID: 34944413] (Bioassay, Human)	Bioassay	Human
R Sagawa, S Sakata, B Gong, Y Seto, A Takemoto, S Takagi, H Ninomiya, N Yanagitani, M Nakao, M Mun, K Uchibori, M Nishio, Y Miyazaki, Y Shiraishi, S Ogawa, K Kataoka, N Fujita, K Takeuchi, R Katayama Soluble PD-L1 through alternative polyadenylation works as a decoy in lung cancer immunotherapy JCI Insight, 2021;0(0):. 2021 [PMID: 34874919] (Bioassay, Human)	Bioassay	Human
Y Hu, H Zhang, N Xie, D Liu, Y Jiang, Z Liu, D Ye, S Liu, X Chen, C Li, Q Wang, X Huang, Y Liu, Y Shi, X Zhang Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1 Cell Death and Differentiation, 2021;0(0):. 2021 [PMID: 34853447] (Bioassay, Mouse)	Bioassay	Mouse
A Fu, L van Rooyen, L Evans, N Armstrong, D Avizonis, T Kin, GH Bird, A Reddy, ET Chouchani, M Liesa-Roig, LD Walensky, AMJ Shapiro, NN Danial Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets Cell Reports, 2021;37(8):110037. 2021 [PMID: 34818536] (Bioassay, Human)	Bioassay	Human
C Xu, J Tang, Q Yang, H Zhao, Y Liu, J Cao, Y Zhou, X Chen, J Chen Histone deacetylase 5 deacetylates the phosphatase PP2A for positively regulating NF-kappaB signaling The Journal of Biological Chemistry, 2021;0(0):101380. 2021 [PMID: 34740611] (Bioassay, Human)	Bioassay	Human
M McAleavy, Q Zhang, PJ Ehmann, J Xu, MF Wipperman, D Ajithdoss, L Pan, M Wakai, R Simonson, A Gadi, A Oyejide, SC Hamon, A Boyapati, LG Morton, T Shavlakadz, CA Kyratsous, DJ Glass The Activin/FLRG pathway associates with poor COVID-19 outcomes in hospitalized patients Molecular and Cellular Biology, 2021;0(0):MCB0046721. 2021 [PMID: 34723652] (Bioassay, Human)	Bioassay	Human
Y Xing, Y Lin, Y Zhang, J Hu, J Liu, Y Tian, J Zhao, W Chen, B Han Novel cytoplasmic lncRNA IKBKBAS promotes lung adenocarcinoma metastasis by upregulating IKKbeta and consequential activation of NF-kappaB signaling pathway Cell Death & Disease, 2021;12(11):1004. 2021 [PMID: 34702815] (Bioassay, Human)	Bioassay	Human
G Panattoni, R Amoriello, C Memo, A Thalhammer, C Ballerini, L Ballerini Diverse inflammatory threats modulate astrocytes Ca2+ signaling via connexin43 hemichannels in organotypic spinal slices Molecular Brain, 2021;14(1):159. 2021 [PMID: 34696792] (Bioassay, Mouse)	Bioassay	Mouse
VA Samara, S Das, MA Reddy, VS Tanwar, K Stapleton, A Leung, M Abdollahi, R Ganguly, L Lanting, R Natarajan Angiotensin II-Induced Long Non-Coding RNA Alivec Regulates Chondrogenesis in Vascular Smooth Muscle Cells Cells, 2021;10(10):. 2021 [PMID: 34685676] (Cell Culture, Rat)	Cell Culture	Rat
S Kochumon, A Al-Sayyar, T Jacob, A Hasan, F Al-Mulla, S Sindhu, R Ahmad TNF-alpha Increases IP-10 Expression in MCF-7 Breast Cancer Cells via Activation of the JNK/c-Jun Pathways Biomolecules, 2021;11(9):. 2021 [PMID: 34572567] (Bioassay, Human)	Bioassay	Human
I Papazian, E Tsoukala, A Boutou, M Karamita, K Kambas, L Iliopoulou, R Fischer, RE Kontermann, MC Denis, G Kollias, H Lassmann, L Probert Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKbeta promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice Journal of Neuroinflammation, 2021;18(1):222. 2021 [PMID: 34565380] (Bioassay, Mouse)	Bioassay	Mouse
S Shao, J Chen, WR Swindell, LC Tsoi, X Xing, F Ma, R Uppala, MK Sarkar, O Plazyo, AC Billi, R Wasikowski, KM Smith, P Honore, VE Scott, E Maverakis, JM Kahlenberg, G Wang, NL Ward, PW Harms, JE Gudjonsson Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris JCI Insight, 2021;0(0):. 2021 [PMID: 34491907] (Bioassay, Human)	Bioassay	Human
N Javeed, TK Her, MR Brown, P Vanderboom, K Rakshit, AM Egan, A Vella, I Lanza, AV Matveyenko Pro-inflammatory beta cell small extracellular vesicles induce beta cell failure through activation of the CXCL10/CXCR3 axis in diabetes Cell Reports, 2021;36(8):109613. 2021 [PMID: 34433033] (Stimulation, Mouse)	Stimulation	Mouse
S Vangeti, T Strandin, S Liu, J Tauriainen, A Räisänen-S, LE Cabrera, A Hassinen, S Mäkelä, J Mustonen, A Vaheri, O Vapalahti, J Klingström, A Smed-Sören Correction: Monocyte subset redistribution from blood to kidneys in patients with Puumala virus caused hemorrhagic fever with renal syndrome PloS Pathogens, 2021;17(8):e1009876. 2021 [PMID: 34432861] (Bioassay, Human)	Bioassay	Human
T Bluhmki, S Traub, AK Müller, S Bitzer, E Schruf, MT Bammert, M Leist, F Gantner, JP Garnett, R Heilker Functional human iPSC-derived alveolar-like cells cultured in a miniaturized 96?Transwell air-liquid interface model Scientific Reports, 2021;11(1):17028. 2021 [PMID: 34426605] (Bioassay, Human)	Bioassay	Human
R Biavasco, E Lettera, K Giannetti, D Gilioli, S Beretta, A Conti, S Scala, D Cesana, P Gallina, M Norelli, L Basso-Ricc, A Bondanza, G Cavalli, M Ponzoni, L Dagna, C Doglioni, A Aiuti, I Merelli, R Di Micco, E Montini Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis Nature Communications, 2021;12(1):4559. 2021 [PMID: 34315896] (Bioassay, Human)	Bioassay	Human
AM Abu El-Asr, MI Nawaz, A Ahmad, MM Siddiquei, E Allegaert, PW Gikandi, G De Hertogh, G Opdenakker CD146/Soluble CD146 Pathway Is a Novel Biomarker of Angiogenesis and Inflammation in Proliferative Diabetic Retinopathy Investigative Ophthalmology & Visual Science, 2021;62(9):32. 2021 [PMID: 34293080] (Bioassay, Human)	Bioassay	Human
S Honda, K Ikeda, R Urata, E Yamazaki, N Emoto, S Matoba Cellular senescence promotes endothelial activation through epigenetic alteration, and consequently accelerates atherosclerosis Scientific Reports, 2021;11(1):14608. 2021 [PMID: 34272458] (Bioassay, Human)	Bioassay	Human
W Soonthornc, P Tangtanata, K Meesilpavi, V Dalm, P Kueanjinda, J Wongpiyabo MicroRNA-378a-3p is overexpressed in psoriasis and modulates cell cycle arrest in keratinocytes via targeting BMP2 gene Scientific Reports, 2021;11(1):14186. 2021 [PMID: 34244572] (Bioassay, Human)	Bioassay	Human
L Liu, B Zheng, Z Wang Protective effects of the knockdown of lncRNA AK139328 against oxygen glucose deprivation/reoxygenation-induced injury in PC12 cells Molecular Medicine Reports, 2021;24(3):. 2021 [PMID: 34212979] (Rat)		Rat
KMA Abdel-Raou, R Rezgui, C Stefanini, JCM Teo, N Christofor Transdifferentiation of Human Fibroblasts into Skeletal Muscle Cells: Optimization and Assembly into Engineered Tissue Constructs through Biological Ligands Biology, 2021;10(6):. 2021 [PMID: 34208436] (Bioassay, Human)	Bioassay	Human
K Andelid, K Öst, A Andersson, E Mohamed, Z Jevnikar, LEGW Vanfletere, M Göransson Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis Respiratory Research, 2021;22(1):172. 2021 [PMID: 34098956] (Bioassay, Human)	Bioassay	Human
S Yan, Q Li, D Zhang, X Wang, Y Xu, C Zhang, D Guo, Y Bao Necroptosis pathway blockage attenuates PFKFB3 inhibitor-induced cell viability loss and genome instability in colorectal cancer cells American journal of cancer research, 2021;11(5):2062-2080. 2021 [PMID: 34094669] (Bioassay, Human)	Bioassay	Human
N Tamassia, F Bianchetto, S Gasperini, S Polletti, E Gardiman, R Ostuni, G Natoli, MA Cassatella Induction of OCT2 contributes to regulate the gene expression program in human neutrophils activated via TLR8 Cell Reports, 2021;35(7):109143. 2021 [PMID: 34010659] (Bioassay, Human)	Bioassay	Human
M Zelic, F Pontarelli, L Woodworth, C Zhu, A Mahan, Y Ren, M LaMorte, R Gruber, A Keane, P Loring, L Guo, TH Xia, B Zhang, P Orning, E Lien, A Degterev, T Hammond, D Ofengeim RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis Cell Reports, 2021;35(6):109112. 2021 [PMID: 33979622] (Bioassay, Human)	Bioassay	Human
B Galinski, M Luxemburg, Y Landesman, B Pawel, KJ Johnson, SR Master, KW Freeman, DM Loeb, JM Hébert, DA Weiser XPO1 inhibition with selinexor synergizes with proteasome inhibition in neuroblastoma by targeting nuclear export of IkB Translational Oncology, 2021;14(8):101114. 2021 [PMID: 33975179] (Bioassay, Human)	Bioassay	Human
S Wang, B Li, V Solomon, A Fonteh, SI Rapoport, DA Bennett, Z Arvanitaki, HC Chui, C Miller, PM Sullivan, HY Wang, HN Yassine Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4 Molecular Neurodegeneration, 2021;16(1):26. 2021 [PMID: 33863362] (Bioassay, Mouse)	Bioassay	Mouse
SR Sripathi, MW Hu, MM Liu, J Wan, J Cheng, Y Duan, JL Mertz, KJ Wahlin, J Maruotti, CA Berlinicke, J Qian, DJ Zack Transcriptome Landscape of Epithelial to Mesenchymal Transition of Human Stem Cell-Derived RPE Investigative Ophthalmology & Visual Science, 2021;62(4):1. 2021 [PMID: 33792620] (Tissue Culture, Human)	Tissue Culture	Human
P Rueda, J Merlin, S Chimenti, M Feletou, J Paysant, PJ White, A Christopou, PM Sexton, RJ Summers, WN Charman, LT May, CJ Langmead Pharmacological Insights Into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure Frontiers in Pharmacology, 2021;12(0):628060. 2021 [PMID: 33776771] (Bioassay, Rat)	Bioassay	Rat
P Gao, P Gao, J Zhao, S Shan, W Luo, OJ Slivano, W Zhang, A Tabuchi, SA LeMaire, L Maegdefess, YH Shen, JM Miano, HA Singer, X Long MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm Redox Biology, 2021;41(0):101903. 2021 [PMID: 33667992] (Bioassay, Human)	Bioassay	Human
D Biswas, P Ambalavana, M Ravins, A Anand, A Sharma, KXZ Lim, RYM Tan, HY Lim, A Sol, G Bachrach, V Angeli, E Hanski LL-37-mediated activation of host receptors is critical for defense against group A streptococcal infection Cell Reports, 2021;34(9):108766. 2021 [PMID: 33657368] (Bioassay, Human)	Bioassay	Human
J Cai, D Hu, J Sakya, T Sun, D Wang, L Wang, X Mao, Z Su ABIN-1 is a key regulator in RIPK1-dependent apoptosis (RDA) and necroptosis, and ABIN-1 deficiency potentiates necroptosis-based cancer therapy in colorectal cancer Cell Death & Disease, 2021;12(2):140. 2021 [PMID: 33542218] (Bioassay, Human)	Bioassay	Human
B Moser, B Hochreiter, J Basílio, V Gleitsmann, A Panhuber, A Pardo-Garc, B Hoesel, M Salzmann, U Resch, M Noreen, JA Schmid The inflammatory kinase IKK&alpha phosphorylates and stabilizes c-Myc and enhances its activity Molecular Cancer, 2021;20(1):16. 2021 [PMID: 33461590] (Bioassay, Human)	Bioassay	Human
TM Garcia-Bat, ML Palma, RR Anderko, DC Hsu, J Ananworani, BT Korber, GD Gaiha, N Phanuphak, R Thomas, S Tovanabutr, BD Walker, JW Mellors, PA Piazza, E Kroon, SA Riddler, NL Michael, CR Rinaldo, RB Mailliard, I4C and RV Dendritic cells focus CTL responses toward highly conserved and topologically important HIV-1 epitopes EBioMedicine, 2021;63(0):103175. 2021 [PMID: 33450518] (Bioassay, Human)	Bioassay	Human
NB Khalaf, D Al-?ehatab, DM Fathallah Vascular endothelial ERp72 is involved in the inflammatory response in a rat model of skeletal muscle injury Molecular Medicine Reports, 2021;23(3):. 2021 [PMID: 33398381] (Bioassay, Human)	Bioassay	Human
Q Dai, Y Zhang, X Liao, Y Jiang, X Lv, X Yuan, J Meng, Y Xie, Z Peng, Q Yuan, L Tao, L Huang Fluorofenidone Alleviates Renal Fibrosis by Inhibiting Necroptosis Through RIPK3/MLKL Pathway Frontiers in Pharmacology, 2020;11(0):534775. 2020 [PMID: 33390935] (Cell Culture, Human)	Cell Culture	Human
NE Efstathiou, GA Moustafa, DE Maidana, EK Konstantin, S Notomi, PRT Barbisan, CD Georgakopo, JW Miller, DG Vavvas Acadesine suppresses TNF-&alpha induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells PLoS ONE, 2020;15(12):e0244307. 2020 [PMID: 33362238] (Bioassay, Human)	Bioassay	Human
A Dorronsoro, V Lang, I Ferrin, J Fernández-, L Zabaleta, E Pérez-Ruiz, P Sepúlveda, C Trigueros Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation Scientific Reports, 2020;10(1):21853. 2020 [PMID: 33318571] (Bioassay, Human)	Bioassay	Human
PN Song, A Mansur, KJ Dugger, TR Davis, G Howard, TE Yankeelov, AG Sorace CD4 T-cell immune stimulation of HER2?+?breast cancer cells alters response to trastuzumab in vitro Cancer Cell International, 2020;20(1):544. 2020 [PMID: 33292267] (Bioassay, Human)	Bioassay	Human
V Simion, H Zhou, S Haemmig, JB Pierce, S Mendes, Y Tesmenitsk, D Pérez-Crem, JF Lee, AF Chen, N Ronda, B Papotti, JA Marto, MW Feinberg A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus Nature Communications, 2020;11(1):6135. 2020 [PMID: 33262333] (Cell Culture, Mouse)	Cell Culture	Mouse
J Stebbing, G Sánchez Ni, M Falcone, S Youhanna, P Richardson, S Ottaviani, JX Shen, C Sommerauer, G Tiseo, L Ghiadoni, A Virdis, F Monzani, LR Rizos, F Forfori, A Avendaño-C, S De Marco, L Carrozzi, F Lena, PM Sánchez-Ju, LG Lacerenza, N Cesira, D Caldevilla, A Perrella, L Niccoli, LS Méndez, D Matarrese, D Goletti, YJ Tan, V Monteil, G Dranitsari, F Cantini, A Farcomeni, S Dutta, SK Burley, H Zhang, M Pistello, W Li, M Mas Romero, F Andrés Pre, RS Simón-Tale, R García-Mol, C Kutter, JH Felce, ZF Nizami, AG Miklosi, JM Penninger, F Menichetti, A Mirazimi, P Abizanda, VM Lauschke JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality Sci Adv, 2020;0(0):. 2020 [PMID: 33187978] (Spheroid Culture, Human)	Spheroid Culture	Human
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VV Edara, S Nooka, J Proulx, S Stacy, A Ghorpade, K Borgmann &beta-Catenin Regulates Wound Healing and IL-6 Expression in Activated Human Astrocytes Biomedicines, 2020;8(11):. 2020 [PMID: 33171974] (Cell Culture, Human)	Cell Culture	Human
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K Landgraf, N Klöting, M Gericke, N Maixner, E Guiu-Jurad, M Scholz, AV Witte, F Beyer, JT Schwartze, M Lacher, A Villringer, P Kovacs, A Rudich, M Blüher, W Kiess, A Körner The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG Cell Rep, 2020;33(3):108295. 2020 [PMID: 33086065] (Bioassay, Mouse)	Bioassay	Mouse
F Al-Rashed, R Thomas, A Al-Roub, F Al-Mulla, R Ahmad LPS Induces GM-CSF Production by Breast Cancer MDA-MB-231 Cells via Long-Chain Acyl-CoA Synthetase 1 Molecules, 2020;25(20):. 2020 [PMID: 33066575] (Bioassay, Human)	Bioassay	Human
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S Nagel, C Pommerenke, C Meyer, RAF MacLeod, HG Drexler Aberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia PLoS ONE, 2020;15(10):e0240120. 2020 [PMID: 33048949] (Cell Culture, Human)	Cell Culture	Human
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S Panigrahi, B Chen, M Fang, D Potashniko, AA Komissarov, A Lebedeva, GM Michaelson, JM Wyrick, SR Morris, SF Sieg, M Paiardini, FJ Villinger, K Harth, VS Kashyap, MJ Cameron, CM Cameron, E Vasilieva, L Margolis, SA Younes, NT Funderburg, DA Zidar, MM Lederman, ML Freeman CX3CL1 and IL-15 Promote CD8 T cell chemoattraction in HIV and in atherosclerosis PLoS Pathog, 2020;16(9):e1008885. 2020 [PMID: 32976527] (Cell Culture, Human)	Cell Culture	Human
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M Paplinska-, P Misiukiewi, M Proboszcz, P Nejman-Gry, K Gorska, R Krenke The Expressions of TSLP, IL-33, and IL-17A in Monocyte Derived Dendritic Cells from Asthma and COPD Patients are Related to Epithelial-Macrophage Interactions Cells, 2020;9(9):. 2020 [PMID: 32842623] (Cell Culture, Human)	Cell Culture	Human
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T Bluhmki, Bluhmki T, Bitzer S, S Bitzer, JA Gindele, Gindele J, Schruf E, E Schruf, T Kiechle, Kiechle T, M Webster, J Schymeinsk, R Ries, Ries R, F Gantner, D Bischoff, Bischoff D, J Garnett, R Heilker, Heilker R Development of a miniaturized 96-Transwell air-liquid interface human small airway epithelial model. Sci Rep, 0;10(1):13022. 0 [PMID: 32747751] (Bioassay, Human)	Bioassay	Human
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BH Clausen, M Wirenfeldt, SS Høgedal, LH Frich, HH Nielsen, HD Schrøder, K Østergaard, B Finsen, BW Kristensen, KL Lambertsen Characterization of the TNF and IL-1 systems in human brain and blood after ischemic stroke Acta Neuropathol Commun, 2020;8(1):81. 2020 [PMID: 32503645] (Bioassay, Human)	Bioassay	Human
K Watanabe, Y Taketomi, Y Miki, K Kugiyama, M Murakami Group V secreted phospholipase A2 plays a protective role against aortic dissection J. Biol. Chem., 2020;295(30):10092-10111. 2020 [PMID: 32482892] (Cell Culture, Human)	Cell Culture	Human
J Seo, D Seong, YW Nam, CH Hwang, SR Lee, CS Lee, Y Jin, HW Lee, DB Oh, P Vandenabee, J Song Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complex Cell Death Differ., 2020;0(0):. 2020 [PMID: 32457484] (Cell Culture)	Cell Culture
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A Nikonova, M Khaitov, DJ Jackson, S Traub, MB Trujillo-T, DA Kudlay, AS Dvornikov, A Del-Rosari, R Valenta, LA Stanciu, R Khaitov, SL Johnston M1-like macrophages are potent producers of anti-viral interferons and M1-associated marker-positive lung macrophages are decreased during rhinovirus-induced asthma exacerbations EBioMedicine, 2020;54(0):102734. 2020 [PMID: 32279057] (Cell Culture, Human)	Cell Culture	Human
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T Mang, S Lindemann, A Gigout Increasing the Medium Osmolarity Reduces the Inflammatory Status of Human OA Chondrocytes and Increases Their Responsiveness to GDF-5 Int J Mol Sci, 2020;21(2):. 2020 [PMID: 31947660] (Cell Culture, Human)	Cell Culture	Human
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JC Chamcheu, S Esnault, VM Adhami, AL Noll, S Banang-Mbe, T Roy, SS Singh, S Huang, KG Kousoulas, H Mukhtar Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models Cells, 2019;8(9):. 2019 [PMID: 31540162] (Bioassay, Human)	Bioassay	Human
NW Zammit, OM Siggs, PE Gray, K Horikawa, DB Langley, SN Walters, SR Daley, C Loetsch, J Warren, JY Yap, D Cultrone, A Russell, EK Malle, JE Villanueva, MJ Cowley, V Gayevskiy, ME Dinger, R Brink, D Zahra, G Chaudhri, G Karupiah, B Whittle, C Roots, E Bertram, M Yamada, Y Jeelall, A Enders, BE Clifton, PD Mabbitt, CJ Jackson, SR Watson, CN Jenne, LL Lanier, T Wiltshire, MH Spitzer, GP Nolan, F Schmitz, A Aderem, BT Porebski, AM Buckle, DW Abbott, JB Ziegler, ME Craig, P Benitez-Ag, J Teo, SG Tangye, C King, M Wong, MP Cox, W Phung, J Tang, W Sandoval, IE Wertz, D Christ, CC Goodnow, ST Grey Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity Nat. Immunol., 2019;20(10):1299-1310. 2019 [PMID: 31534238] (Bioassay, Mouse)	Bioassay	Mouse
J Ren, M Smid, J Iaria, DCF Salvatori, H van Dam, HJ Zhu, JWM Martens, P Ten Dijke Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression Breast Cancer Res., 2019;21(1):109. 2019 [PMID: 31533776] (Bioassay, Human)	Bioassay	Human
J Merola, M Reschke, RW Pierce, L Qin, S Spindler, T Baltazar, TD Manes, F Lopez-Gira, G Li, LG Bracaglia, C Xie, N Kirkiles-S, WM Saltzman, GT Tietjen, G Tellides, JS Pober Progenitor-derived human endothelial cells evade alloimmunity by CRISPR/Cas9-mediated complete ablation of MHC expression JCI Insight, 2019;0(0):. 2019 [PMID: 31527312] (Bioassay, Human)	Bioassay	Human
G Barbero, MV Castro, MB Villanueva, MJ Quezada, NB Fernández, S DeMorrow, P Lopez-Berg An Autocrine Wnt5a Loop Promotes NF-kappaB Pathway Activation and Cytokine/Chemokine Secretion in Melanoma Cells, 2019;8(9):. 2019 [PMID: 31510045] (Bioassay, Human)	Bioassay	Human
C Jiang, SJ Trudeau, TC Cheong, R Guo, M Teng, LW Wang, Z Wang, C Pighi, C Gautier-Co, Y Ma, S Jiang, C Wang, B Zhao, L Paillard, JG Doench, R Chiarle, BE Gewurz CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation Cell Rep, 2019;28(5):1307-1322.e8. 2019 [PMID: 31365872] (Cell Culture, Human)	Cell Culture	Human
X Liu, Z Li, H Liu, Y Zhu, D Xia, S Wang, R Gu, W Wu, P Zhang, Y Liu, Y Zhou Low concentration flufenamic acid enhances osteogenic differentiation of mesenchymal stem cells and suppresses bone loss by inhibition of the NF-κB signaling pathway Stem Cell Res Ther, 2019;10(1):213. 2019 [PMID: 31324207] (Cell Culture, Human)	Cell Culture	Human
Z Ye, L Zhong, S Zhu, Y Wang, J Zheng, S Wang, J Zhang, R Huang The P-selectin and PSGL-1 axis accelerates atherosclerosis via activation of dendritic cells by the TLR4 signaling pathway Cell Death Dis, 2019;10(7):507. 2019 [PMID: 31263109] (Bioassay, Human)	Bioassay	Human
LY Wang, XJ Sun, M Chen, MH Zhao The expression of NOD2, NLRP3 and NLRC5 and renal injury in anti-neutrophil cytoplasmic antibody-associated vasculitis J Transl Med, 2019;17(1):197. 2019 [PMID: 31186034] (Cell Culture, Human)	Cell Culture	Human
BD Bryson, TR Rosebrock, FG Tafesse, CY Itoh, A Nibasumba, GH Babunovic, B Corleis, C Martin, C Keegan, P Andrade, S Realegeno, D Kwon, RL Modlin, SM Fortune Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis Nat Commun, 2019;10(1):2329. 2019 [PMID: 31133636] (Bioassay, Human)	Bioassay	Human
N Zhang, DP Heruth, W Wu, LQ Zhang, MN Nsumu, K Shortt, K Li, X Jiang, B Wang, C Friesen, DY Li, SQ Ye Functional characterization of SLC26A3 c.392C>G (p.P131R) mutation in intestinal barrier function using CRISPR/CAS9-created cell models Cell Biosci, 2019;9(0):40. 2019 [PMID: 31114672] (Cell Culture, Human)	Cell Culture	Human
C Rosette, FJ Agan, N Rosette, L Moro, A Mazzetti, C Hassan, M Gerloni Rifamycin SV exhibits strong anti-inflammatory in�vitro activity through pregnane X receptor stimulation and NF?B inhibition Drug Metab. Pharmacokinet., 2019;34(3):172-180. 2019 [PMID: 31101589] (Bioassay, Human)	Bioassay	Human
R van Dalen, JS De La Cruz, M Rumpret, FF Fuchsberge, NH van Teijli, J Hanske, C Rademacher, TBH Geijtenbee, JAG van Strijp, C Weidenmaie, A Peschel, DH Kaplan, NM van Sorge Langerhans Cells Sense Staphylococcus aureus Wall Teichoic Acid through Langerin To Induce Inflammatory Responses MBio, 2019;10(3):. 2019 [PMID: 31088921] (Bioassay, Human)	Bioassay	Human
SM Ferrari, F Ragusa, SR Paparo, F Nasini, M Nardi, SS Franceschi, P Fallahi, A Antonelli Differential modulation of CXCL8 versus CXCL10, by cytokines, PPAR-gamma, or PPAR-alpha agonists, in primary cells from Graves' disease and ophthalmopathy Autoimmun Rev, 2019;0(0):. 2019 [PMID: 31059842] (Bioassay, Human)	Bioassay	Human
WY Lai, JW Wang, BT Huang, EP Lin, PC Yang A Novel TNF-?-Targeting Aptamer for TNF-?-Mediated Acute Lung Injury and Acute Liver Failure Theranostics, 2019;9(6):1741-1751. 2019 [PMID: 31037135] (Bioassay, Human)	Bioassay	Human
N Wang, C Luo, H Liu, X Yang, B Hu, W Zhang, B Li, Y Zhu, G Zhu, X Shen, C Peng, Z Shi Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus Bats Viruses, 2019;11(4):. 2019 [PMID: 31022925] (Bioassay, Human)	Bioassay	Human
M Liu, CQ Xiao, MW Sun, MJ Tan, LH Hu, Q Yu Xanthatin inhibits STAT3 and NF-?B signalling by covalently binding to JAK and IKK kinases J. Cell. Mol. Med., 2019;0(0):. 2019 [PMID: 30993883] (Bioassay, Human)	Bioassay	Human
MR Hadjichara, BT Roux, E Csomor, CA Feghali-Bo, LA Murray, DL Clarke, MA Lindsay Long intergenic non-coding RNAs regulate human lung fibroblast function: Implications for idiopathic pulmonary fibrosis Sci Rep, 2019;9(1):6020. 2019 [PMID: 30988425] (Bioassay, Human)	Bioassay	Human
IB Mitre-Agui, T Barrios-Ga, VM Ruiz-Lopez, AJ Cabrera-Qu, NR Mejia-Domi, JL Ventura-Ga, D Moreno-Mit, A Aranda-Gut, J Mejia-Rang, AR Escalona-G, Y Chavarri-G, A Leon-Del-R, A Zentella-D Glucocorticoid-dependent expression of IAP participates in the protection against TNF-mediated cytotoxicity in MCF7 cells BMC Cancer, 2019;19(1):356. 2019 [PMID: 30987626] (Bioassay, Human)	Bioassay	Human
J Kristoff, ML Palma, TM Garcia-Bat, C Shen, N Sluis-Crem, P Gupta, CR Rinaldo, RB Mailliard Type 1-programmed dendritic cells drive antigen-specific latency reversal and immune elimination of persistent HIV-1 EBioMedicine, 2019;0(0):. 2019 [PMID: 30952614] (Bioassay, Human)	Bioassay	Human
S De Alessan, GJ Ferguson, AJ Dodd, JK Juss, A Devaprasad, S Piper, O Wyatt, H Killick, DJ Corkill, ES Cohen, A Pandit, TRDJ Radstake, R Simmonds, AM Condliffe, MA Sleeman, AS Cowburn, DK Finch, ER Chilvers Neutrophil GM-CSF receptor dynamics in acute lung injury J. Leukoc. Biol., 2019;0(0):. 2019 [PMID: 30942918] (Bioassay, Human)	Bioassay	Human
K Wang, S Fang, Q Liu, J Gao, X Wang, H Zhu, Z Zhu, F Ji, J Wu, Y Ma, L Hu, X Shen, D Gao, J Zhu, P Liu, H Zhou TGF-?1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM EBioMedicine, 2019;0(0):. 2019 [PMID: 30926424] (Bioassay, Human)	Bioassay	Human
T Liu, Q Zeng, X Zhao, W Wei, Y Li, H Deng, D Song Synthesis and Biological Evaluation of Fangchinoline Derivatives as Anti-Inflammatory Agents through Inactivation of Inflammasome Molecules, 2019;24(6):. 2019 [PMID: 30909541] (Bioassay, Human)	Bioassay	Human
JC de Quaglia, AM Della Cole, TP Gardizani, GG Romagnoli, R Kaneno, LA Dias-Melic Involvement of the Dectin-1 Receptor upon the Effector Mechanisms of Human Phagocytic Cells against Paracoccidioides brasiliensis J Immunol Res, 2019;2019(0):1529189. 2019 [PMID: 30882002] (Bioassay, Human)	Bioassay	Human
Q An, Y Zheng, Y Zhao, T Liu, H Guo, D Zhang, W Qian, H Wang, Y Guo, S Hou, J Li Physicochemical characterization and phase I study of CMAB008, an infliximab biosimilar produced by a different expression system Drug Des Devel Ther, 2019;13(0):791-805. 2019 [PMID: 30880912] (Bioassay, Mouse)	Bioassay	Mouse
X Cheng, X Qiu, Y Liu, C Yuan, X Yang Trimethylamine N-oxide promotes tissue factor expression and activity in vascular endothelial cells: A new link between trimethylamine N-oxide and atherosclerotic thrombosis Thromb. Res., 2019;177(0):110-116. 2019 [PMID: 30875490] (Bioassay, Human)	Bioassay	Human
H Xu, B Wang, M Ono, A Kagita, K Fujii, N Sasakawa, T Ueda, P Gee, M Nishikawa, M Nomura, F Kitaoka, T Takahashi, K Okita, Y Yoshida, S Kaneko, A Hotta Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility Cell Stem Cell, 2019;0(0):. 2019 [PMID: 30853558] (Bioassay, Human)	Bioassay	Human
B Podder, C Guttà, J Rožanc, E Gerlach, M Feoktistov, D Panayotova, LG Alexopoulo, M Leverkus, M Rehm TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma Cell Death Differ., 2019;0(0):. 2019 [PMID: 30850732] (Bioassay, Human)	Bioassay	Human
Y Zhao, Y Li, R Qu, X Chen, W Wang, C Qiu, B Liu, X Pan, L Liu, K Vasilev, J Hayball, S Dong, W Li Cortistatin binds to TNF-? receptors and protects against osteoarthritis EBioMedicine, 2019;0(0):. 2019 [PMID: 30826358] (Bioassay, Human)	Bioassay	Human
V Laubach, R Kaufmann, A Bernd, S Kippenberg, N Zöller Extrinsic or Intrinsic Apoptosis by Curcumin and Light: Still a Mystery Int J Mol Sci, 2019;20(4):. 2019 [PMID: 30791477] (Bioassay, Human)	Bioassay	Human
K Spekker-Bo, CM Ufermann, M Maywald, A Zimmermann, A Domröse, C Woite, W Däubener, SK Eller hCMV-Mediated Immune Escape Mechanisms Favor Pathogen Growth and Disturb the Immune Privilege of the Eye Int J Mol Sci, 2019;20(4):. 2019 [PMID: 30781494] (Bioassay, Human)	Bioassay	Human
T Kaprio, T Rasila, J Hagström, H Mustonen, P Lankila, C Haglund, LC Andersson Ornithine decarboxylase antizyme inhibitor 2 (AZIN2) is a signature of secretory phenotype and independent predictor of adverse prognosis in colorectal cancer PLoS ONE, 2019;14(2):e0211564. 2019 [PMID: 30768610] (Bioassay, Human)	Bioassay	Human
Y Wang, Y Liu, M Zhang, L Lv, X Zhang, P Zhang, Y Zhou Inhibition of PTGS1 promotes osteogenic differentiation of adipose-derived stem cells by suppressing NF-kB signaling Stem Cell Res Ther, 2019;10(1):57. 2019 [PMID: 30760327] (Bioassay, Human)	Bioassay	Human
AA Khawaja, C Pericleous, VM Ripoll, JC Porter, IP Giles Autoimmune rheumatic disease IgG has differential effects upon neutrophil integrin activation that is modulated by the endothelium Sci Rep, 2019;9(1):1283. 2019 [PMID: 30718722] (Bioassay, Human)	Bioassay	Human
BA Kane, H An, P Rajasekari, HP McNeil, K Bryant, N Tedla Differential expression and regulation of the non-integrin 37/67-kDa laminin receptor on peripheral blood leukocytes of healthy individuals and patients with rheumatoid arthritis Sci Rep, 2019;9(1):1149. 2019 [PMID: 30718719] (Bioassay, Human)	Bioassay	Human
M Bobardt, J Kuo, U Chatterji, S Chanda, SJ Little, N Wiedemann, G Vuagniaux, PA Gallay The inhibitor apoptosis protein antagonist Debio 1143 Is an attractive HIV-1 latency reversal candidate PLoS ONE, 2019;14(2):e0211746. 2019 [PMID: 30716099] (Bioassay, Human)	Bioassay	Human
T Karnezis, R Farnsworth, NC Harris, SP Williams, C Caesar, DJ Byrne, P Herle, ML Macheda, R Shayan, YF Zhang, S Yazar, SJ Takouridis, C Gerard, S Fox, MG Achen, SA Stacker CCL27/CCL28-CCR10 CHEMOKINE SIGNALING MEDIATES MIGRATION OF LYMPHATIC ENDOTHELIAL CELLS Cancer Res., 2019;0(0):. 2019 [PMID: 30709930] (Bioassay, Human)	Bioassay	Human
S Murakami, R Matsumoto, T Kanamori Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system Sci Rep, 2019;9(1):671. 2019 [PMID: 30679500] (ELISA (Capture), Human)	ELISA (Capture)	Human
Y Zhang, Q Xia, Y Li, Z He, Z Li, T Guo, Z Wu, N Feng CD44 Assists the Topical Anti-Psoriatic Efficacy of Curcumin-Loaded Hyaluronan-Modified Ethosomes: A New Strategy for Clustering Drug in Inflammatory Skin Theranostics, 2019;9(1):48-64. 2019 [PMID: 30662553] (Bioassay, Human)	Bioassay	Human
SE Jin, H Ha, HK Shin, CS Seo Anti-Allergic and Anti-Inflammatory Effects of Kuwanon G and Morusin on MC/9 Mast Cells and HaCaT Keratinocytes Molecules, 2019;24(2):. 2019 [PMID: 30642008] (Bioassay, Human)	Bioassay	Human
K Ni, A Gill, D Cao, K Koike, KS Schweitzer, S Garantziot, I Petrache Intravascular heavy chain-modification of hyaluronan during endotoxic shock Biochem Biophys Rep, 2019;17(0):114-121. 2019 [PMID: 30623115] (Bioassay, Human)	Bioassay	Human
K Bohn-Wippe, EN Tevonian, Y Lu, MY Huang, MR Megaridis, RD Dar Cell Size-Based Decision-Making of a Viral Gene Circuit Cell Rep, 2018;25(13):3844-3857.e5. 2018 [PMID: 30590053] (Bioassay, Human)	Bioassay	Human
SJ Lee, J Kim, J Ko, EJ Lee, HJ Koh, JS Yoon Tumor necrosis factor-like weak inducer of apoptosis induces inflammation in Graves' orbital fibroblasts PLoS ONE, 2018;13(12):e0209583. 2018 [PMID: 30576385] (Human)		Human
Q Li, W Xing, X Gong, Y Wang Long Non-Coding RNA Urothelial Carcinoma Associated 1 Promotes Proliferation, Migration and Invasion of Osteosarcoma Cells by Regulating microRNA-182 Cell. Physiol. Biochem., 2018;51(3):1149-1163. 2018 [PMID: 30481751] (Bioassay, Human)	Bioassay	Human
M Rentschler, Y Chen, J Pahl, L Soria-Mart, H Braumüller, E Brenner, O Bischof, M Röcken, T Wieder Nuclear Translocation of Argonaute 2 in Cytokine-Induced Senescence Cell. Physiol. Biochem., 2018;51(3):1103-1118. 2018 [PMID: 30476917] (Bioassay, Human)	Bioassay	Human
MS Shihabudee, X Cheng, M Moran, S Haemmig, MJ Naldrett, S Alvarez, MW Feinberg, X Sun LncRNA Meg3 protects endothelial function by regulating the DNA damage response Nucleic Acids Res., 2018;0(0):. 2018 [PMID: 30476192] (Bioassay, Human)	Bioassay	Human
T Gräber, H Kluge, S Granica, G Horn, J Kalbitz, C Brandsch, A Breitenste, C Brütting, GI Stangl Agrimonia procera exerts antimicrobial effects, modulates the expression of defensins and cytokines in colonocytes and increases the immune response in lipopolysaccharide-challenged piglets BMC Vet. Res., 2018;14(1):346. 2018 [PMID: 30442133] (Bioassay, Human)	Bioassay	Human
S Perriot, A Mathias, G Perriard, M Canales, N Jonkmans, N Merienne, C Meunier, L El Kassar, AL Perrier, DA Laplaud, M Schluep, N Déglon, R Du Pasquie Human Induced Pluripotent Stem Cell-Derived Astrocytes Are Differentially Activated by Multiple Sclerosis-Associated Cytokines Stem Cell Reports, 2018;11(5):1199-1210. 2018 [PMID: 30409508] (Bioassay, Human)	Bioassay	Human
IT Lee, CF Lin, YL Huang, KY Chong, MF Hsieh, TH Huang, CY Cheng Protective mechanisms of resveratrol derivatives against TNF-?-induced inflammatory responses in rat mesangial cells Cytokine, 2018;0(0):. 2018 [PMID: 30389230] (Bioassay, Rat)	Bioassay	Rat
WM Vanderheyd, AG Goodman, RH Taylor, MG Frank, HPA Van Dongen, JR Gerstner Astrocyte expression of the Drosophila TNF-alpha homologue, Eiger, regulates sleep in flies PLoS Genet., 2018;14(10):e1007724. 2018 [PMID: 30379810] (In Vivo, Drosophila)	In Vivo	Drosophila
L Mercurio, M Morelli, C Scarponi, EZ Eisenmesse, N Doti, G Pagnanelli, E Gubinelli, C Mazzanti, A Cavani, M Ruvo, CA Dinarello, C Albanesi, S Madonna IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment Cell Death Dis, 2018;9(11):1104. 2018 [PMID: 30377293] (Bioassay, Human)	Bioassay	Human
TD Manes, V Wang, JS Pober Divergent TCR-Initiated Calcium Signals Govern Recruitment versus Activation of Human Alloreactive Effector Memory T Cells by Endothelial Cells J. Immunol., 2018;0(0):. 2018 [PMID: 30341183] (Bioassay, Human)	Bioassay	Human
GH Yang, C Zhang, N Wang, Y Meng, YS Wang Anacardic acid suppresses fibroblast-like synoviocyte proliferation and invasion and ameliorates collagen-induced arthritis in a mouse model Cytokine, 2018;111(0):350-356. 2018 [PMID: 30273785] (Bioassay, Human)	Bioassay	Human
S Li, X Yang, Z Feng, P Wang, W Zhu, S Cui Catalase Enhances Viability of Human Chondrocytes in Culture by Reducing Reactive Oxygen Species and Counteracting Tumor Necrosis Factor-?-Induced Apoptosis Cell. Physiol. Biochem., 2018;49(6):2427-2442. 2018 [PMID: 30261500] (Bioassay, Human)	Bioassay	Human
K Wongdee, M Rodrat, C Keadsai, W Jantarajit, J Teerapornp, J Thongbunch, N Charoenpha Activation of calcium-sensing receptor by allosteric agonists cinacalcet and AC-265347 abolishes the 1,25(OH)2D3-induced Ca2+ transport: Evidence that explains how the intestine prevents excessive Ca2+ absorption Arch. Biochem. Biophys., 2018;657(0):15-22. 2018 [PMID: 30217510] (Bioassay, Human)	Bioassay	Human
Y Tanaka, L Sabharwal, M Ota, I Nakagawa, JJ Jiang, Y Arima, H Ogura, M Okochi, M Ishii, D Kamimura, M Murakami Presenilin 1 Regulates NF-?B Activation via Association with Breakpoint Cluster Region and Casein Kinase II J. Immunol., 2018;0(0):. 2018 [PMID: 30201812] (Bioassay, Mouse)	Bioassay	Mouse
V Tisato, S Gallo, E Melloni, C Celeghini, A Passaro, G Zauli, P Secchiero, C Bergamini, A Trentini, G Bonaccorsi, G Valacchi, G Zuliani, C Cervellati TRAIL and Ceruloplasmin Inverse Correlation as a Representative Crosstalk between Inflammation and Oxidative Stress Mediators Inflamm., 2018;2018(0):9629537. 2018 [PMID: 30147446] (Bioassay, Human)	Bioassay	Human
É Boros, Z Kellermaye, P Balogh, G Strifler, A Vörös, P Sarlós, Á Vincze, C Varga, I Nagy Elevated Expression of AXL May Contribute to the Epithelial-to-Mesenchymal Transition in Inflammatory Bowel Disease Patients Mediators Inflamm., 2018;2018(0):3241406. 2018 [PMID: 30140167] (Bioassay, Human)	Bioassay	Human
M Schwede, EM Wilfong, RL Zemans, PJ Lee, C Dos Santos, X Fang, MA Matthay Effects of bone marrow-derived mesenchymal stromal cells on gene expression in human alveolar type II cells exposed to TNF-?, IL-1?, and IFN-? Physiol Rep, 2018;6(16):e13831. 2018 [PMID: 30136410] (Bioassay, Human)	Bioassay	Human
AL Means, TJ Freeman, J Zhu, LG Woodbury, P Marincola-, C Wu, AR Meyer, CJ Weaver, C Padmanabha, H An, J Zi, BC Wessinger, R Chaturvedi, TD Brown, NG Deane, RJ Coffey, KT Wilson, JJ Smith, CL Sawyers, JR Goldenring, SV Novitskiy, MK Washington, C Shi, RD Beauchamp Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer Cell Mol Gastroenterol Hepatol, 2018;6(3):257-276. 2018 [PMID: 30109253] (Bioassay, Mouse)	Bioassay	Mouse
SL Figenschau, E Knutsen, I Urbarova, C Fenton, B Elston, M Perander, ES Mortensen, KA Fenton ICAM1 expression is induced by proinflammatory cytokines and associated with TLS formation in aggressive breast cancer subtypes Sci Rep, 2018;8(1):11720. 2018 [PMID: 30082828] (Bioassay, Human)	Bioassay	Human
S Ishii, T Isozaki, H Furuya, H Takeuchi, Y Tsubokura, K Inagaki, T Kasama ADAM-17 is expressed on rheumatoid arthritis fibroblast-like synoviocytes and regulates proinflammatory mediator expression and monocyte adhesion Arthritis Res. Ther., 2018;20(1):159. 2018 [PMID: 30071898] (Bioassay, Human)	Bioassay	Human
SI Jeong, JW Kim, KP Ko, BK Ryu, MG Lee, HJ Kim, SG Chi XAF1 forms a positive feedback loop with IRF-1 to drive apoptotic stress response and suppress tumorigenesis Cell Death Dis, 2018;9(8):806. 2018 [PMID: 30042418] (Bioassay, Human)	Bioassay	Human
JJ Seeley, RG Baker, G Mohamed, T Bruns, MS Hayden, SD Deshmukh, DE Freedberg, S Ghosh Induction of innate immune memory via microRNA targeting of chromatin remodelling factors Nature, 2018;559(7712):114-119. 2018 [PMID: 29950719] (Bioassay, Mouse)	Bioassay	Mouse
G Genard, AC Wera, C Huart, B Le Calve, S Penninckx, A Fattacciol, T Tabarrant, C Demazy, N Ninane, AC Heuskin, S Lucas, C Michiels Proton irradiation orchestrates macrophage reprogramming through NF?B signaling Cell Death Dis, 2018;9(7):728. 2018 [PMID: 29950610] (Bioassay, Human)	Bioassay	Human
W Feng, Y Wu, G Chen, S Fu, B Li, B Huang, D Wang, W Wang, J Liu Sodium Butyrate Attenuates Diarrhea in Weaned Piglets and Promotes Tight Junction Protein Expression in Colon in a GPR109A-Dependent Manner Cell. Physiol. Biochem., 2018;47(4):1617-1629. 2018 [PMID: 29949795] (Bioassay, Human)	Bioassay	Human
Michael J Workman, John P Gleeson, Elissa J Troisi, Hannah Q Estrada, S Jordan Kerns, Christopher D Hinojosa, Geraldine A Hamilton, Stephan R Targan, Clive N Svendsen, Robert J Barrett Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips. Cellular and Molecular Gastroenterology and Hepatology, 2018;0(0):2352-345X. 2018 [PMID: 29930984] (Bioassay, Human)	Bioassay	Human
A Gaudin, M Tolar, OA Peters Lipoxin A4 Attenuates the Inflammatory Response in Stem Cells of the Apical Papilla via ALX/FPR2 Sci Rep, 2018;8(1):8921. 2018 [PMID: 29892010] (Bioassay, Human)	Bioassay	Human
JA Marwick, R Mills, O Kay, K Michail, J Stephen, AG Rossi, I Dransfield, N Hirani Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-?B activation Cell Death Dis, 2018;9(6):665. 2018 [PMID: 29867198] (Bioassay, Human)	Bioassay	Human
SU Seo, SM Woo, HS Lee, SH Kim, KJ Min, TK Kwon mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy Oncogene, 2018;0(0):. 2018 [PMID: 29849119] (Bioassay, Human)	Bioassay	Human
S Hemmati-Sa, J Ringe, T Dehne, R Haag, M Sittinger Hyaluronic Acid Influence on Normal and Osteoarthritic Tissue-Engineered Cartilage Int J Mol Sci, 2018;19(5):. 2018 [PMID: 29783732] (Bioassay, Human)	Bioassay	Human
E Vorkapic, A Kunath, D Wågsäter Effects of osteoprotegerin/TNFRSF11B in two models of abdominal aortic aneurysms Mol Med Rep, 2018;0(0):. 2018 [PMID: 29749489] (Bioassay, Human)	Bioassay	Human
AE Dodi, IO Ajayi, C Chang, M Beard, SL Ashley, SK Huang, VJ Thannickal, DJ Tschumperl, TH Sisson, JC Horowitz Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli Respir. Res., 2018;19(1):91. 2018 [PMID: 29747634] (Bioassay, Human)	Bioassay	Human
BN Nakamura, A Glazier, MG Kattah, B Duong, Y Jia, D Campo, L Shao A20 regulates canonical wnt-signaling through an interaction with RIPK4 PLoS ONE, 2018;13(5):e0195893. 2018 [PMID: 29718933] (Bioassay, Human)	Bioassay	Human
M Boyd, M Thodberg, M Vitezic, J Bornholdt, K Vitting-Se, Y Chen, M Coskun, Y Li, BZS Lo, P Klausen, P Jan Schwei, AG Pedersen, N Rapin, K Skovgaard, K Dahlgaard, R Andersson, TB Terkelsen, B Lilje, JT Troelsen, AM Petersen, KB Jensen, I Gögenur, P Thielsen, JB Seidelin, OH Nielsen, JT Bjerrum, A Sandelin Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies Nat Commun, 2018;9(1):1661. 2018 [PMID: 29695774] (Bioassay, Human)	Bioassay	Human
A Beringer, N Thiam, J Molle, B Bartosch, P Miossec Synergistic effect of interleukin-17 and tumor necrosis factor-α on inflammatory response in hepatocytes through interleukin-6 dependent and independent pathways Clin. Exp. Immunol., 2018;0(0):. 2018 [PMID: 29676779] (Bioassay, Human)	Bioassay	Human
H Kim, SR Kim, J Je, K Jeong, S Kim, HJ Kim, KC Chang, SW Park The proximal tubular ?7 nicotinic acetylcholine receptor attenuates ischemic acute kidney injury through Akt/PKC signaling-mediated HO-1 induction Exp. Mol. Med., 2018;50(4):40. 2018 [PMID: 29674665] (Bioassay, Human)	Bioassay	Human
JP Parisien, JJ Lenoir, R Mandhana, KR Rodriguez, K Qian, AM Bruns, CM Horvath RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling EMBO Rep., 2018;0(0):. 2018 [PMID: 29661858] (Bioassay, Human)	Bioassay	Human
M Brown, LA Johnson, DA Leone, P Majek, K Vaahtomeri, D Senfter, N Bukosza, H Schachner, G Asfour, B Langer, R Hauschild, K Parapatics, YK Hong, KL Bennett, R Kain, M Detmar, M Sixt, DG Jackson, D Kerjaschki Lymphatic exosomes promote dendritic cell migration along guidance cues J. Cell Biol., 2018;0(0):. 2018 [PMID: 29650776] (Bioassay, Human)	Bioassay	Human
J Weiler, M Mohr, KS Zänker, T Dittmar Matrix metalloproteinase-9 (MMP9) is involved in the TNF-α-induced fusion of human M13SV1-Cre breast epithelial cells and human MDA-MB-435-pFDR1 cancer cells Cell Commun. Signal, 2018;16(1):14. 2018 [PMID: 29636110] (Bioassay, Human)	Bioassay	Human
C Lema, RY Reins, RL Redfern High-Mobility Group Box 1 in Dry Eye Inflammation Invest. Ophthalmol. Vis. Sci., 2018;59(5):1741-1750. 2018 [PMID: 29610858] (Bioassay, Human)	Bioassay	Human
R Drolia, S Tenguria, AC Durkes, JR Turner, AK Bhunia Listeria Adhesion Protein Induces Intestinal Epithelial Barrier Dysfunction for Bacterial Translocation Cell Host Microbe, 2018;0(0):. 2018 [PMID: 29606495] (Bioassay, Human)	Bioassay	Human
M Gabl, M Sundqvist, A Holdfeldt, S Lind, J Mårtensson, K Christenso, T Marutani, C Dahlgren, H Mukai, H Forsman Mitocryptides from Human Mitochondrial DNA-Encoded Proteins Activate Neutrophil Formyl Peptide Receptors: Receptor Preference and Signaling Properties J. Immunol., 2018;0(0):. 2018 [PMID: 29602776] (Bioassay, Human)	Bioassay	Human
O Sokolova, T Kähne, K Bryan, M Naumann Interactome analysis of transforming growth factor-?-activated kinase 1 inHelicobacter pylori-infected cells revealed novel regulators tripartite motif 28 and CDC37 Oncotarget, 2018;9(18):14366-14381. 2018 [PMID: 29581850] (Bioassay, Human)	Bioassay	Human
L Gao, MM Liu, HM Zang, QY Ma, Q Yang, L Jiang, GL Ren, HD Li, WF Wu, JN Wang, B Wei, XQ Liu, C Jiang, C Huang, J Li, XM Meng Restoration of E-cadherin by PPBICA protects against cisplatin-induced acute kidney injury by attenuating inflammation and programmed cell death Lab. Invest., 2018;0(0):. 2018 [PMID: 29581579] (Bioassay, Mouse)	Bioassay	Mouse
D Sireesh, U Dhamodhara, K Ezhilarasi, V Vijay, KM Ramkumar Association of NF-E2 Related Factor 2 (Nrf2) and inflammatory cytokines in recent onset Type 2 Diabetes Mellitus Sci Rep, 2018;8(1):5126. 2018 [PMID: 29572460] (Bioassay, Human)	Bioassay	Human
C Napoletano, S Mattiucci, A Colantoni, F Battisti, IG Zizzari, H Rahimi, M Nuti, A Rughetti Anisakis pegreffii impacts differentiation and function of human dendritic cells Parasite Immunol., 2018;0(0):e12527. 2018 [PMID: 29569735] (Bioassay, Human)	Bioassay	Human
CM Dickinson, BW LeBlanc, MM Edhi, DS Heffernan, MH Faridi, V Gupta, WG Cioffi, X O'Brien, JS Reichner Leukadherin-1 ameliorates endothelial barrier damage mediated by neutrophils from critically ill patients J Intensive Care, 2018;6(0):19. 2018 [PMID: 29568527] (Bioassay, Human)	Bioassay	Human
S Ikeya, JI Sakabe, T Yamada, T Naito, Y Tokura Voriconazole-induced photocarcinogenesis is promoted by aryl hydrocarbon receptor-dependent COX-2 upregulation Sci Rep, 2018;8(1):5050. 2018 [PMID: 29568008] (Bioassay, Human)	Bioassay	Human
M Toutfaire, E Dumortier, A Fattacciol, MV Steenbrugg, CM Proby, F Debacq-Cha Unraveling the interplay between senescent dermal fibroblasts and cutaneous squamous cell carcinoma cell lines at different stages of tumorigenesis Int. J. Biochem. Cell Biol., 2018;0(0):. 2018 [PMID: 29550586] (Bioassay, Human)	Bioassay	Human
S Modi, N Yaluri, T Kokkola Strigolactone GR24 and pinosylvin attenuate adipogenesis and inflammation of white adipocytes Biochem. Biophys. Res. Commun., 2018;0(0):. 2018 [PMID: 29550483] (Bioassay, Mouse)	Bioassay	Mouse
KA Jhang, JS Park, HS Kim, YH Chong Sulforaphane rescues amyloid-? peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages J Neuroinflammation, 2018;15(1):75. 2018 [PMID: 29530050] (Bioassay, Human)	Bioassay	Human
K Flentie, C Gonzalez, B Kocher, Y Wang, H Zhu, J Marasa, D Piwnica-Wo Nucleoside Diphosphate Kinase-3 (NME3) Enhances TLR5-Induced NF-?B Activation Mol. Cancer Res., 2018;0(0):. 2018 [PMID: 29523766] (Bioassay, Human)	Bioassay	Human
Y Wang, Y Liu, M Zhang, L Lv, X Zhang, P Zhang, Y Zhou LRRC15 promotes osteogenic differentiation of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation Stem Cell Res Ther, 2018;9(1):65. 2018 [PMID: 29523191] (Bioassay, Human)	Bioassay	Human
E Canto, N Isobe, A Didonna, , SL Hauser, JR Oksenberg Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients J Neuroinflammation, 2018;15(1):72. 2018 [PMID: 29514694] (Bioassay, Human)	Bioassay	Human
S Wink, SW Hiemstra, S Huppelscho, JE Klip, B van de Wat Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury Arch. Toxicol., 2018;0(0):. 2018 [PMID: 29502165] (Bioassay, Human)	Bioassay	Human
JG Chen, X Liu, M Munshi, L Xu, N Tsakmaklis, MG Demos, A Kofides, ML Guerrera, GG Chan, CJ Patterson, KE Meid, J Gustine, T Dubeau, P Severns, JJ Castillo, ZR Hunter, J Wang, SJ Buhrlage, NS Gray, SP Treon, G Yang BTKCys481Serdrives ibrutinib resistance via ERK1/2, and protects BTKWild-TypeMYD88 mutated cells by a paracrine mechanism Blood, 2018;0(0):. 2018 [PMID: 29496671] (Bioassay, Human)	Bioassay	Human
P Singhirunn, B Moolmuang, K Lirdprapam, M Ruchirawat Arsenite exposure potentiates apoptosis-inducing effects of tumor necrosis factor-alpha- through reactive oxygen species J Toxicol Sci, 2018;43(2):159-169. 2018 [PMID: 29479036] (Bioassay, Human)	Bioassay	Human
CH Lee, HH Zhang, SP Singh, L Koo, J Kabat, H Tsang, TP Singh, JM Farber C/EBP? drives interactions between human MAIT cells and endothelial cells that are important for extravasation Elife, 2018;7(0):. 2018 [PMID: 29469805] (Bioassay, Human)	Bioassay	Human
LH Wright, DJ Herr, SS Brown, H Kasiganesa, DR Menick Angiokine Wisp-1 is increased in myocardial infarction and regulates cardiac endothelial signaling JCI Insight, 2018;3(4):. 2018 [PMID: 29467324] (Bioassay, Human)	Bioassay	Human
Y Wang, VM Abrahams, G Luo, NG Norwitz, VV Snegovskik, SW Ng, ER Norwitz Progesterone Inhibits Apoptosis in Fetal Membranes by Altering Expression of Both Pro- and Antiapoptotic Proteins Reprod Sci, 2018;0(0):1933719118759. 2018 [PMID: 29463188] (Bioassay, Human)	Bioassay	Human
A Lundin, L Delsing, M Clausen, P Ricchiuto, J Sanchez, A Sabirsh, M Ding, J Synnergren, H Zetterberg, G Brolén, R Hicks, A Herland, A Falk Human iPS-Derived Astroglia from a Stable Neural Precursor State Show Improved Functionality Compared with Conventional Astrocytic Models Stem Cell Reports, 2018;0(0):. 2018 [PMID: 29456185] (Bioassay, Human)	Bioassay	Human
G Bi, L Wu, P Huang, S Islam, DP Heruth, LQ Zhang, DY Li, V Sampath, W Huang, BA Simon, RB Easley, SQ Ye Up-regulation of SFTPB expression and attenuation of acute lung injury by pulmonary epithelial cell-specific NAMPT knockdown FASEB J., 2018;0(0):fj201701059R. 2018 [PMID: 29452569] (Bioassay, Human)	Bioassay	Human
AJ Lakhter, RE Pratt, RE Moore, KK Doucette, BF Maier, LA DiMeglio, EK Sims Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes Diabetologia, 2018;0(0):. 2018 [PMID: 29445851] (Cell Culture, Human)	Cell Culture	Human
TD Jung, SI Choi, SH Choi, BY Cho, WS Sim, , SJ Lee, SJ Park, DB Kim, YC Kim, JH Lee, OH Lee Changes in the Anti-Allergic Activities of Sesame by Bioconversion Nutrients, 2018;10(2):. 2018 [PMID: 29443928] (Bioassay, Human)	Bioassay	Human
AW Clarke, L Poulton, D Shim, D Mabon, D Butt, M Pollard, V Pande, J Husten, J Lyons, C Tian, AG Doyle An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease MAbs, 2018;0(0):1-43. 2018 [PMID: 29436901] (Surface Plasmon Resonance (SPR, Human)	Surface Plasmon Resonance (SPR	Human
WR Swindell, MA Beamer, MK Sarkar, S Loftus, J Fullmer, X Xing, NL Ward, LC Tsoi, MJ Kahlenberg, Y Liang, JE Gudjonsson RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature Front Immunol, 2018;9(0):80. 2018 [PMID: 29434599] (Cell Culture, Human)	Cell Culture	Human
M Frank-Bert, DS Pisetsky, C Kolling, BA Michel, RE Gay, A Jüngel, S Gay TLR3 Ligand Poly(I:C) Exerts Distinct Actions in Synovial Fibroblasts When Delivered by Extracellular Vesicles Front Immunol, 2018;9(0):28. 2018 [PMID: 29434584] (Bioassay, Human)	Bioassay	Human
M Armaka, C Ospelt, M Pasparakis, G Kollias The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts Nat Commun, 2018;9(1):618. 2018 [PMID: 29434332] (Bioassay, Human)	Bioassay	Human
MA Rapsomanik, XK Lun, S Woerner, M Laumanns, B Bodenmille, MR Martínez CellCycleTRACER accounts for cell cycle and volume in mass cytometry data Nat Commun, 2018;9(1):632. 2018 [PMID: 29434325] (Bioassay, Human)	Bioassay	Human
M Miyauchi, M Ao, H Furusho, C Chea, A Nagasaki, S Sakamoto, T Ando, T Inubushi, K Kozai, T Takata Galectin-3 Plays an Important Role in Preterm Birth Caused by Dental Infection of Porphyromonas gingivalis Sci Rep, 2018;8(1):2867. 2018 [PMID: 29434245] (Bioassay, Human)	Bioassay	Human
W Klement, R Garbelli, E Zub, L Rossini, L Tassi, B Girard, M Blaquiere, F Bertaso, J Perroy, F de Bock, N Marchi Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature Neurobiol. Dis., 2018;0(0):. 2018 [PMID: 29432809] (Cell Culture, Human)	Cell Culture	Human
M Oshima, KP Knoch, M Diedisheim, A Petzold, P Cattan, M Bugliani, P Marchetti, P Choudhary, GC Huang, SR Bornstein, M Solimena, O Albagli-Cu, R Scharfmann Virus-like infection induces human ? cell dedifferentiation JCI Insight, 2018;3(3):. 2018 [PMID: 29415896] (Bioassay, Human)	Bioassay	Human
L Chung, ET Orberg, AL Geis, JL Chan, K Fu, CED Shields, CM Dejea, P Fathi, J Chen, BB Finard, AJ Tam, FM McAllister, H Fan, X Wu, S Ganguly, A Lebid, P Metz, SW Van Meerbe, DL Huso, EC Wick, DM Pardoll, F Wan, S Wu, CL Sears, F Housseau Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells Cell Host Microbe, 2018;0(0):. 2018 [PMID: 29398651] (Bioassay, Human)	Bioassay	Human
K Ouhara, S Munenaga, M Kajiya, K Takeda, S Matsuda, Y Sato, Y Hamamoto, T Iwata, S Yamasaki, K Akutagawa, N Mizuno, T Fujita, E Sugiyama, H Kurihara The induced RNA-binding protein, HuR targets 3'-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis Clin. Exp. Immunol., 2018;0(0):. 2018 [PMID: 29393507] (Bioassay, Human)	Bioassay	Human
F Zhang, G Liu, D Li, C Wei, J Hao DDIT4 and Associated lncDDIT4 Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway J. Immunol., 2018;0(0):. 2018 [PMID: 29378913] (Bioassay, Human)	Bioassay	Human
JS Edmisson, S Tian, CL Armstrong, A Vashishta, CK Klaes, I Miralda, E Jimenez-Fl, J Le, Q Wang, RJ Lamont, SM Uriarte Filifactor alocis modulates human neutrophil antimicrobial functional responses Cell. Microbiol., 2018;0(0):. 2018 [PMID: 29377528] (Cell Culture, Human)	Cell Culture	Human
A Rutkowska, DR Shimshek, AW Sailer, KK Dev EBI2 regulates pro-inflammatory signalling and cytokine release in astrocytes Neuropharmacology, 2018;133(0):121-128. 2018 [PMID: 29374507] (Bioassay, Human)	Bioassay	Human
L Bin, X Li, B Richers, JE Streib, JW Hu, P Taylor, DYM Leung ANKRD1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum J. Allergy Clin. Immunol., 2018;0(0):. 2018 [PMID: 29371118] (Cell Culture, Human)	Cell Culture	Human
L Tengroth, J Arebro, O Larsson, C Bachert, SK Georén, LO Cardell Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps Sci Rep, 2018;8(1):1561. 2018 [PMID: 29367682] (Bioassay, Human)	Bioassay	Human
X Zhang, Y Zhang, J Xu, H Wang, X Zheng, Y Lou, B Han Antigen presentation of the Oct4 and Sox2 peptides by CD154-activated B lymphocytes enhances the killing effect of cytotoxic T lymphocytes on tumor stem-like cells derived from cisplatin-resistant lung cancer cells J Cancer, 2018;9(2):367-374. 2018 [PMID: 29344283] (Bioassay, Human)	Bioassay	Human
R Jalili, J Horecka, JR Swartz, RW Davis, HHJ Persson Streamlined circular proximity ligation assay provides high stringency and compatibility with low-affinity antibodies Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):. 2018 [PMID: 29339495] (Bioassay)	Bioassay
M Medelin, V Giacco, A Aldinucci, G Castronovo, E Bonechi, A Sibilla, M Tanturli, M Torcia, L Ballerini, F Cozzolino, C Ballerini Bridging pro-inflammatory signals, synaptic transmission and protection in spinal explants in vitro Mol Brain, 2018;11(1):3. 2018 [PMID: 29334986] (Bioassay, Mouse)	Bioassay	Mouse
TA Nakada, P Wacharasin, JA Russell, JH Boyd, E Nakada, SA Thair, T Shimada, KR Walley The IL20 Genetic Polymorphism Is Associated with Altered Clinical Outcome in Septic Shock J Innate Immun, 2018;0(0):. 2018 [PMID: 29334679] (Bioassay, Human)	Bioassay	Human
HD Brightbill, E Suto, N Blaquiere, N Ramamoorth, S Sujatha-Bh, EB Gogol, GM Castanedo, BT Jackson, YC Kwon, S Haller, J Lesch, K Bents, C Everett, PB Kohli, S Linge, L Christian, K Barrett, A Jaochico, LM Berezhkovs, PW Fan, Z Modrusan, K Veliz, MJ Townsend, J DeVoss, AR Johnson, R Godemann, WP Lee, CD Austin, BS McKenzie, JA Hackney, JJ Crawford, ST Staben, MH Alaoui Ism, LC Wu, N Ghilardi NF-?B inducing kinase is a therapeutic target for systemic lupus erythematosus Nat Commun, 2018;9(1):179. 2018 [PMID: 29330524] (Bioassay, Human)	Bioassay	Human
Y Zhang, S Wang, H Dong, X Yi, J Zhang, X Liu, R Zhuang, Y Ding LAIR-1 shedding from human fibroblast-like synoviocytes in rheumatoid arthritis following TNF-? stimulation Clin. Exp. Immunol., 2018;0(0):. 2018 [PMID: 29328500] (Bioassay, Human)	Bioassay	Human
B Jeong, HR Kim, NS Choi, BS Park, H Eom, JW Park, JG Kim, BJ Lee Role of thyroid transcription factor-1 in transcriptional regulation of heme oxygenase-1 Biochem. Biophys. Res. Commun., 2018;0(0):. 2018 [PMID: 29305861] (In Vivo, Mouse)	In Vivo	Mouse
X Zhong, HN Lee, YJ Surh RvD1 inhibits TNF?-induced c-Myc expression in normal intestinal epithelial cells and destabilizes hyper-expressed c-Myc in colon cancer cells Biochem. Biophys. Res. Commun., 2018;0(0):. 2018 [PMID: 29305860] (Bioassay, Human)	Bioassay	Human
TD Zaikos, MM Painter, NT Sebastian, VH Terry, KL Collins Class 1-selective histone deacetylase inhibitors enhance HIV latency reversal while preserving the activity of HDAC isoforms necessary for maximal HIV gene expression J. Virol., 2018;0(0):. 2018 [PMID: 29298886] (Bioassay, Human)	Bioassay	Human
YJ Choi, SJ Park, YS Park, HS Park, KM Yang, K Heo EpCAM peptide-primed dendritic cell vaccination confers significant anti-tumor immunity in hepatocellular carcinoma cells PLoS ONE, 2018;13(1):e0190638. 2018 [PMID: 29298343] (Bioassay, Human)	Bioassay	Human
S Gogia, A Kelkar, C Zhang, KM Dayananda, S Neelamegha Role of calcium in regulating the intra- and extracellular cleavage of von Willebrand factor by the protease ADAMTS13 Blood Adv, 2017;1(23):2063-2074. 2017 [PMID: 29296853] (Western Blot)	Western Blot
N Cheng, Y Guo Long noncoding RNA NEAT1 promotes nasopharyngeal carcinoma progression through regulation of miR-124/NF-?B pathway Onco Targets Ther, 2017;10(0):5843-5853. 2017 [PMID: 29270022] (Bioassay, Human)	Bioassay	Human
AM Abu El-Asr, K Alam, M Garcia-Ram, A Ahmad, MM Siddiquei, G Mohammad, A Mousa, G De Hertogh, G Opdenakker, R Simó Association of HMGB1 with oxidative stress markers and regulators in PDR Mol. Vis., 2017;23(0):853-871. 2017 [PMID: 29259392] (Bioassay, Human)	Bioassay	Human
T Tanaka, Y Zhou, T Ozawa, R Okizono, A Banba, T Yamamura, E Oga, A Muraguchi, H Sakurai Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation J. Biol. Chem., 2017;0(0):. 2017 [PMID: 29255092] (Bioassay, Human)	Bioassay	Human
AT Holdbrooks, CM Britain, SL Bellis ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptor J. Biol. Chem., 2017;0(0):. 2017 [PMID: 29233887] (Bioassay, Human)	Bioassay	Human
Y Xu, S Xu, P Liu, M Koroleva, S Zhang, S Si, ZG Jin Suberanilohydroxamic Acid as a Pharmacological Kruppel-Like Factor 2 Activator That Represses Vascular Inflammation and Atherosclerosis J Am Heart Assoc, 2017;6(12):. 2017 [PMID: 29191808] (Bioassay, Human)	Bioassay	Human
N Han, L Shi, Q Guo, W Sun, Y Yu, L Yang, X Zhang, M Zhang HAT1 induces lung cancer cell apoptosis via up regulating Fas Oncotarget, 2017;8(52):89970-89977. 2017 [PMID: 29163803] (Bioassay, Human)	Bioassay	Human
WS Yang, SY Moon, MJ Lee, EK Lee, SK Park Diosgenin, an Activator of 1,25D3-MARRS Receptor/ERp57, Attenuates the Effects of TNF-? by Causing ADAM10-Dependent Ectodomain Shedding of TNF Receptor 1 Cell. Physiol. Biochem., 2017;43(6):2434-2445. 2017 [PMID: 29073626] (Bioassay, Human)	Bioassay	Human
D Yee, KM Shah, MC Coles, TV Sharp, D Lagos MicroRNA-155 induction via TNF-? and IFN-? suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells J. Biol. Chem., 2017;292(50):20683-20693. 2017 [PMID: 29066622] (Bioassay, Human)	Bioassay	Human
NN Mehta, HL Teague, WR Swindell, Y Baumer, NL Ward, X Xing, B Baugous, A Johnston, AA Joshi, J Silverman, DH Barnes, L Wolterink, RP Nair, PE Stuart, M Playford, JJ Voorhees, MK Sarkar, JT Elder, K Gallagher, SK Ganesh, JE Gudjonsson IFN-? and TNF-? synergism may provide a link between psoriasis and inflammatory atherogenesis Sci Rep, 2017;7(1):13831. 2017 [PMID: 29062018] (Bioassay, Human)	Bioassay	Human
MA Peplowski, AJ Vegso, V Iablokov, M Dicay, RS Zaheer, B Renaux, D Proud, MD Hollenberg, PL Beck, WK MacNaughto Tumor necrosis factor ? decreases aquaporin 3 expression in intestinal epithelial cells through inhibition of constitutive transcription Physiol Rep, 2017;5(19):. 2017 [PMID: 29038361] (Bioassay, Human)	Bioassay	Human
H Mogami, A Hari Kisho, Y Akgul, RA Word Healing of Preterm Ruptured Fetal Membranes Sci Rep, 2017;7(1):13139. 2017 [PMID: 29030612] (Bioassay, Human)	Bioassay	Human
S Ebtehaj, EG Gruppen, M Parvizi, UJF Tietge, RPF Dullaart The anti-inflammatory function of HDL is impaired in type 2 diabetes: role of hyperglycemia, paraoxonase-1 and low grade inflammation Cardiovasc Diabetol, 2017;16(1):132. 2017 [PMID: 29025405] (Bioassay, Human)	Bioassay	Human
Z Wang, MY Li, C Mi, KS Wang, J Ma, X Jin Mollugin Has an Anti-Cancer Therapeutic Effect by Inhibiting TNF-?-Induced NF-?B Activation Int J Mol Sci, 2017;18(8):. 2017 [PMID: 28933726] (Bioassay, Human)	Bioassay	Human
L Qiang, A Sample, CR Shea, K Soltani, KF Macleod, YY He Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis Autophagy, 2017;0(0):0. 2017 [PMID: 28933598] (Bioassay, Human)	Bioassay	Human
D Korenfeld, L Gorvel, A Munk, J Man, A Schaffer, T Tung, C Mann, E Klechevsky A type of human skin dendritic cell marked by CD5 is associated with the development of inflammatory skin disease JCI Insight, 2017;2(18):. 2017 [PMID: 28931765] (Bioassay, Human)	Bioassay	Human
ML Palisoul, JM Quinn, E Schepers, IS Hagemann, L Guo, K Reger, AR Hagemann, CK McCourt, PH Thaker, MA Powell, DG Mutch, KC Fuh Inhibition of the Receptor Tyrosine Kinase AXL Restores Paclitaxel Chemosensitivity in Uterine Serous Cancer Mol. Cancer Ther., 2017;0(0):. 2017 [PMID: 28904132] (Bioassay, Human)	Bioassay	Human
N Akbar, JE Digby, TJ Cahill, AN Tavare, AL Corbin, S Saluja, S Dawkins, L Edgar, N Rawlings, K Ziberna, E McNeill, , E Johnson, AA Aljabali, RA Dragovic, M Rohling, TG Belgard, IA Udalova, DR Greaves, KM Channon, PR Riley, DC Anthony, RP Choudhury Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction JCI Insight, 2017;2(17):. 2017 [PMID: 28878126] (Bioassay, Human)	Bioassay	Human
M Matsushita, K Ozawa, T Suzuki, M Nakamura, N Nakano, S Kanchi, D Ichikawa, E Matsuki, M Sakurai, D Karigane, H Kasahara, N Tsukamoto, T Shimizu, T Mori, H Nakajima, S Okamoto, Y Kawakami, Y Hattori CXorf48 is a potential therapeutic target for achieving treatment-free remission in CML patients Blood Cancer J, 2017;7(9):e601. 2017 [PMID: 28862699] (Bioassay, Human)	Bioassay	Human
YK Lee, SW Kim, JY Park, WC Kang, YJ Kang, D Khang Suppression of human arthritis synovial fibroblasts inflammation using dexamethasone-carbon nanotubes via increasing caveolin-dependent endocytosis and recovering mitochondrial membrane potential Int J Nanomedicine, 2017;12(0):5761-5779. 2017 [PMID: 28848352] (Bioassay, Human)	Bioassay	Human
N Starc, D Ingo, A Conforti, V Rossella, L Tomao, A Pitisci, F De Mattia, I Brigida, M Algeri, M Montanari, G Palumbo, P Merli, P Rossi, A Aiuti, F Locatelli, ME Bernardo Biological and functional characterization of bone marrow-derived mesenchymal stromal cells from patients affected by primary immunodeficiency Sci Rep, 2017;7(1):8153. 2017 [PMID: 28811575] (Bioassay, Human)	Bioassay	Human
KA Bailey, FG Haj, SI Simon, AG Passerini Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation Sci Rep, 2017;7(1):8196. 2017 [PMID: 28811527] (Bioassay, Human)	Bioassay	Human
BK Hong, S You, SA Yoo, D Park, D Hwang, CS Cho, WU Kim MicroRNA-143 and -145 modulate the phenotype of synovial fibroblasts in rheumatoid arthritis Exp. Mol. Med., 2017;49(8):e363. 2017 [PMID: 28775366] (Bioassay, Human)	Bioassay	Human
AE van der Wi, IMC Vogels, CJF van Noorde, I Klaassen, RO Schlingema TNF?-Induced Disruption of the Blood-Retinal Barrier In Vitro Is Regulated by Intracellular 3',5'-Cyclic Adenosine Monophosphate Levels Invest. Ophthalmol. Vis. Sci., 2017;58(9):3496-3505. 2017 [PMID: 28715583] (Bioassay, Human)	Bioassay	Human
E Couderc, F Morel, P Levillain, A Buffière-M, M Camus, C Paquier, C Bodet, JF Jégou, M Pohin, L Favot, M Garcia, V Huguier, J Mcheik, C Lacombe, H Yssel, G Guillet, FX Bernard, JC Lecron Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis PLoS ONE, 2017;12(7):e0181486. 2017 [PMID: 28708859] (Bioassay, Human)	Bioassay	Human
Y Haim, M Blüher, D Konrad, N Goldstein, N Klöting, I Harman-Boe, B Kirshtein, D Ginsberg, T Tarnovscki, Y Gepner, I Shai, A Rudich ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype Mol Metab, 2017;6(7):725-736. 2017 [PMID: 28702328] (Bioassay, Human)	Bioassay	Human
R Ahmad, B Rah, D Bastola, P Dhawan, AB Singh Obesity-induces Organ and Tissue Specific Tight Junction Restructuring and Barrier Deregulation by Claudin Switching Sci Rep, 2017;7(1):5125. 2017 [PMID: 28698546] (Bioassay, Human)	Bioassay	Human
J Yuzugulen, JA Douthwaite, EG Wood, IC Villar, NSA Patel, J Jegard, H Gaertner, I Rossitto-B, K Rose, O Hartley, PR Cutillas, A Ahluwalia, R Corder Characterisation of preproendothelin-1 derived peptides identifies Endothelin-Like Domain Peptide as a modulator of Endothelin-1 Sci Rep, 2017;7(1):4956. 2017 [PMID: 28694457] (Bioassay, Human)	Bioassay	Human
SS Chung, Y Wu, Q Okobi, D Adekoya, M Atefi, O Clarke, P Dutta, JV Vadgama Proinflammatory Cytokines IL-6 and TNF-? Increased Telomerase Activity through NF-?B/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells Mediators Inflamm., 2017;2017(0):5958429. 2017 [PMID: 28676732] (Bioassay, Human)	Bioassay	Human
R Connor, LD Jones, X Qiu, J Thakar, SB Maggirwar Frontline Science: c-Myc regulates P-selectin glycoprotein ligand-1 expression in monocytes during HIV-1 infection J. Leukoc. Biol., 2017;0(0):. 2017 [PMID: 28663244] (Bioassay, Human)	Bioassay	Human
L Šenolt, K Prajzlerov, H Hulejová, B Šumová, M Filková, D Veigl, K Pavelka, J Vencovský Interleukin-20 is triggered by TLR ligands and associates with disease activity in patients with rheumatoid arthritis Cytokine, 2017;97(0):187-192. 2017 [PMID: 28662439] (Bioassay, Human)	Bioassay	Human
JD Graci, D Michaels, G Chen, GM Schiralli, S Nodder, M Weetall, GM Karp, Z Gu, JM Colacino, AJ Henderson Identification of benzazole compounds that induce HIV-1 transcription PLoS ONE, 2017;12(6):e0179100. 2017 [PMID: 28658263] (Bioassay, Human)	Bioassay	Human
TL Liao, YM Chen, CW Hsieh, HH Chen, HC Lee, WT Hung, KT Tang, DY Chen Upregulation of circulating microRNA-134 in adult-onset Still's disease and its use as potential biomarker Sci Rep, 2017;7(1):4214. 2017 [PMID: 28646209] (Bioassay, Human)	Bioassay	Human
S Weis, AR Carlos, MR Moita, S Singh, B Blankenhau, S Cardoso, R Larsen, S Rebelo, S Schäuble, L Del Barrio, G Mithieux, F Rajas, S Lindig, M Bauer, MP Soares Metabolic Adaptation Establishes Disease Tolerance to Sepsis Cell, 2017;169(7):1263-1275.e14. 2017 [PMID: 28622511] (Bioassay, Human)	Bioassay	Human
A Pavesi, AT Tan, S Koh, A Chia, M Colombo, E Antonecchi, C Miccolis, E Ceccarello, G Adriani, MT Raimondi, RD Kamm, A Bertoletti A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors JCI Insight, 2017;2(12):. 2017 [PMID: 28614795] (Bioassay, Human)	Bioassay	Human
JS Reyat, M Chimen, PJ Noy, J Szyroka, GE Rainger, MG Tomlinson ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration J. Immunol., 2017;0(0):. 2017 [PMID: 28600292] (Bioassay, Human)	Bioassay	Human
M Fardoun, T Al-Shehabi, A El-Yazbi, K Issa, F Zouein, D Maaliki, R Iratni, AH Eid Ziziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells Oxid Med Cell Longev, 2017;2017(0):4134093. 2017 [PMID: 28593025] (Bioassay, Human)	Bioassay	Human
Z Zhang, Z Stickney, N Duong, K Curley, B Lu AAV-based dual-reporter circuit for monitoring cell signaling in living human cells J Biol Eng, 2017;11(0):18. 2017 [PMID: 28592991] (Bioassay, Human)	Bioassay	Human
R Santos, KC Vadodaria, BN Jaeger, A Mei, S Lefcochilo, APD Mendes, G Erikson, M Shokhirev, L Randolph-M, C Fredlender, S Dave, R Oefner, C Fitzpatric, M Pena, JJ Barron, M Ku, AM Denli, BE Kerman, P Charnay, JR Kelsoe, MC Marchetto, FH Gage Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells Stem Cell Reports, 2017;8(6):1757-1769. 2017 [PMID: 28591655] (Bioassay, Human)	Bioassay	Human
NT Hogan, MB Whalen, LK Stolze, NK Hadeli, MT Lam, JR Springstea, CK Glass, CE Romanoski Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells Elife, 2017;6(0):. 2017 [PMID: 28585919] (Bioassay, Human)	Bioassay	Human
GG Jinesh, AM Kamat RalBP1 and p19-VHL play an oncogenic role, and p30-VHL plays a tumor suppressor role during the blebbishield emergency program Cell Death Discov, 2017;3(0):17023. 2017 [PMID: 28580172] (Bioassay, Human)	Bioassay	Human
D Sagar, NP Singh, R Ginwala, X Huang, R Philip, M Nagarkatti, P Nagarkatti, K Neumann, J Ruland, AM Andrews, SH Ramirez, ZK Khan, P Jain Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity Sci Rep, 2017;7(1):2707. 2017 [PMID: 28578388] (Bioassay, Human)	Bioassay	Human
C Zhang, Z Chen, X Meng, M Li, L Zhang, A Huang The involvement and possible mechanism of pro-inflammatory tumor necrosis factor alpha (TNF-?) in thoracic ossification of the ligamentum flavum PLoS ONE, 2017;12(6):e0178986. 2017 [PMID: 28575129] (Bioassay, Human)	Bioassay	Human
S Khiar, M Lucas-Hour, S Nisole, N Smith, O Helynck, M Bourgine, C Ruffié, JP Herbeuval, H Munier-Leh, F Tangy, PO Vidalain Identification of a small molecule that primes the type I interferon response to cytosolic DNA Sci Rep, 2017;7(1):2561. 2017 [PMID: 28566766] (Bioassay, Human)	Bioassay	Human
K Kinnunen, N Piippo, S Loukovaara, M Hytti, K Kaarnirant, A Kauppinen Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs) J Cell Commun Signal, 2017;0(0):. 2017 [PMID: 28547650] (Bioassay, Human)	Bioassay	Human
M Shioda, T Muneta, K Tsuji, M Mizuno, K Komori, H Koga, I Sekiya TNF? promotes proliferation of human synovial MSCs while maintaining chondrogenic potential PLoS ONE, 2017;12(5):e0177771. 2017 [PMID: 28542363] (Bioassay, Human)	Bioassay	Human
CH Lo, N Vunnam, AK Lewis, TL Chiu, BE Brummel, TM Schaaf, BD Grant, P Bawaskar, DD Thomas, JN Sachs An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors SLAS Discov, 2017;0(0):2472555217706. 2017 [PMID: 28530838] (Bioassay, Human)	Bioassay	Human
Yunbo Ke, Noureddine Zebda, Olga Oskolkova, Taras Afonyushk, Evgeny Berdyshev, Yufeng Tian, Fanyong Meng, Nicolene Sarich, Valery N Bochkov, Ji Ming Wang, Anna A Birukova, Konstantin G Birukov Anti-Inflammatory Effects of OxPAPC Involve Endothelial Cell-Mediated Generation of LXA4. Circulation Research, 2017;0(0):1524-4571. 2017 [PMID: 28522438] (Bioassay, Human)	Bioassay	Human
A Alquraini, M Jamal, L Zhang, T Schmidt, GD Jay, KA Elsaid The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes Arthritis Res. Ther., 2017;19(1):89. 2017 [PMID: 28482921] (Bioassay, Human)	Bioassay	Human
GW He, C Günther, V Thonn, YQ Yu, E Martini, B Buchen, MF Neurath, M Stürzl, C Becker Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice J. Exp. Med., 2017;0(0):. 2017 [PMID: 28476895] (Bioassay, Human)	Bioassay	Human
X Wang, R Wilkinson, K Kildey, J Potriquet, J Mulvenna, RJ Lobb, A Möller, N Cloonan, P Mukhopadhy, AJ Kassianos, H Healy Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions J Extracell Vesicles, 2017;6(1):1314073. 2017 [PMID: 28473886] (Bioassay, Human)	Bioassay	Human
YS Jung, SO Lee Apomorphine suppresses TNF-?-induced MMP-9 expression and cell invasion through inhibition of ERK/AP-1 signaling pathway in MCF-7 cells Biochem. Biophys. Res. Commun., 2017;0(0):. 2017 [PMID: 28465234] (Bioassay, Human)	Bioassay	Human
H Choi, RMC Ignacio, ES Lee, AJ Wilson, D Khabele, DS Son Augmented Serum Amyloid A1/2 Mediated by TNF-induced NF-?B in Human Serous Ovarian Epithelial Tumors Immune Netw, 2017;17(2):121-127. 2017 [PMID: 28458624] (Bioassay, Human)	Bioassay	Human
B Wang, Z Chen, X Meng, M Li, X Yang, C Zhang iTRAQ quantitative proteomic study in patients with thoracic ossification of the ligamentum flavum Biochem. Biophys. Res. Commun., 2017;0(0):. 2017 [PMID: 28455229] (Bioassay, Human)	Bioassay	Human
P Huang, MW Lee, K Sadrerafi, DP Heruth, LQ Zhang, D Maulik, SQ Ye MC-PPEA as a new and more potent inhibitor of CLP-induced sepsis and pulmonary inflammation than FK866 Drug Des Devel Ther, 2017;11(0):629-641. 2017 [PMID: 28424540] (Bioassay, Human)	Bioassay	Human
H Al Faruque, JH Kang, SR Hwang, S Sung, MM Alam, KH Sa, EJ Nam, YR Byun, YM Kang Stepwise inhibition of T cell recruitment at post-capillary venules by orally active desulfated heparins in inflammatory arthritis PLoS ONE, 2017;12(4):e0176110. 2017 [PMID: 28419144] (Bioassay, Human)	Bioassay	Human
KJ Chung, A Chatzigeor, M Economopou, R Garcia-Mar, VI Alexaki, I Mitroulis, M Nati, J Gebler, T Ziemssen, SE Goelz, J Phieler, JH Lim, KP Karalis, T Papayannop, M Blüher, G Hajishenga, T Chavakis A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity Nat. Immunol., 2017;0(0):. 2017 [PMID: 28414311] (Bioassay, Human)	Bioassay	Human
BS Patel, MJ Kugel, G Baehring, AJ Ammit Doxofylline does not increase formoterol-induced cAMP nor MKP-1 expression in ASM cells resulting in lack of anti-inflammatory effect Pulm Pharmacol Ther, 2017;0(0):. 2017 [PMID: 28414142] (Bioassay, Human)	Bioassay	Human
E Redondo-Ca, C Cunningham, J Miller, L Martuscell, S Aoulad-Ali, NJ Rothwell, CM Kielty, SM Allan, E Pinteaux Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro Stem Cell Res Ther, 2017;8(1):79. 2017 [PMID: 28412968] (Bioassay, Human)	Bioassay	Human
E Krayukhina, M Noda, K Ishii, T Maruno, H Wakabayash, M Tada, T Suzuki, A Ishii-Wata, M Kato, S Uchiyama Analytical ultracentrifugation with fluorescence detection system reveals differences in complex formation between recombinant human TNF and different biological TNF antagonists in various environments MAbs, 2017;9(4):664-679. 2017 [PMID: 28387583] (Bioassay)	Bioassay
JW Lee, J Lee, SH Um, EY Moon Synovial cell death is regulated by TNF-?-induced expression of B-cell activating factor through an ERK-dependent increase in hypoxia-inducible factor-1? Cell Death Dis, 2017;8(4):e2727. 2017 [PMID: 28383556] (Bioassay, Human)	Bioassay	Human
H Munir, LS Ward, L Sheriff, S Kemble, S Nayar, F Barone, GB Nash, HM McGettrick Adipogenic differentiation of MSC alters their immunomodulatory properties in a tissue-specific manner Stem Cells, 2017;0(0):. 2017 [PMID: 28376564] (Bioassay, Human)	Bioassay	Human
F Pan, H Xiang, J Yan, L Hong, L Zhang, Y Liu, X Feng, C Cai Dendritic cells from rheumatoid arthritis patient peripheral blood induce Th17 cell differentiation via miR-363/Integrin ?v/TGF-? axis Scand. J. Immunol., 2017;0(0):. 2017 [PMID: 28376277] (Bioassay, Human)	Bioassay	Human
R Havunen, M Siurala, S Sorsa, S Grönberg-V, M Behr, S Tähtinen, JM Santos, P Karell, J Rusanen, DM Nettelbeck, A Ehrhardt, A Kanerva, A Hemminki Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy Mol Ther Oncolytics, 2017;4(0):77-86. 2017 [PMID: 28345026] (Bioassay, Mouse)	Bioassay	Mouse
Z Zhang, Q He, Y Tao, J Guo, F Xu, LY Wu, YS Zhao, D Wu, LY Zhou, JY Su, LX Song, C Xiao, X Li, CK Chang Decitabine treatment sensitizes tumor cells to T-cell-mediated cytotoxicity in patients with myelodysplastic syndromes Am J Transl Res, 2017;9(2):454-465. 2017 [PMID: 28337274] (Bioassay, Human)	Bioassay	Human
Y Kokubu, T Yamaguchi, K Kawabata In�vitro model of cerebral ischemia by using brain microvascular endothelial cells derived from human induced pluripotent stem cells Biochem. Biophys. Res. Commun, 2017;0(0):. 2017 [PMID: 28336435] (Bioassay, Human)	Bioassay	Human
M Frank-Bert, M Trenkmann, K Klein, E Karouzakis, H Rehrauer, A Bratus, C Kolling, M Armaka, A Filer, BA Michel, RE Gay, CD Buckley, G Kollias, S Gay, C Ospelt Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions Nat Commun, 2017;8(0):14852. 2017 [PMID: 28332497] (Bioassay, Human)	Bioassay	Human
M Silva, RK Fung, CB Donnelly, PA Videira, R Sackstein Cell-Specific Variation in E-Selectin Ligand Expression among Human Peripheral Blood Mononuclear Cells: Implications for Immunosurveillance and Pathobiology J. Immunol, 2017;0(0):. 2017 [PMID: 28330896] (Bioassay, Human)	Bioassay	Human
HA Ebhardt, S Degen, V Tadini, A Schilb, N Johns, CA Greig, KC Fearon, R Aebersold, C Jacobi Comprehensive proteome analysis of human skeletal muscle in cachexia and sarcopenia: A pilot study J Cachexia Sarcopenia Muscle, 2017;0(0):. 2017 [PMID: 28296247] (Bioassay, Human)	Bioassay	Human
JS Ainscough, T Macleod, D McGonagle, R Brakefield, JM Baron, A Alase, M Wittmann, M Stacey Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36? Proc. Natl. Acad. Sci. U.S.A, 2017;114(13):E2748-E2757. 2017 [PMID: 28289191] (Bioassay, Human)	Bioassay	Human
J Retzlaff, K Thamm, CC Ghosh, W Ziegler, H Haller, SM Parikh, S David Flunarizine suppresses endothelial Angiopoietin-2 in a calcium - dependent fashion in sepsis Sci Rep, 2017;7(0):44113. 2017 [PMID: 28276491] (Bioassay, Human)	Bioassay	Human
J Arebro, S Ekstedt, E Hjalmarsso, O Winqvist, S Kumlien Ge, LO Cardell A possible role for neutrophils in allergic rhinitis revealed after cellular subclassification Sci Rep, 2017;7(0):43568. 2017 [PMID: 28272395] (Bioassay, Human)	Bioassay	Human
MH Hancock, LM Hook, J Mitchell, JA Nelson Human Cytomegalovirus MicroRNAs miR-US5-1 and miR-UL112-3p Block Proinflammatory Cytokine Production in Response to NF-?B-Activating Factors through Direct Downregulation of IKK? and IKK? MBio, 2017;8(2):. 2017 [PMID: 28270578] (Bioassay, Human)	Bioassay	Human
JA Schwartz, KL Clayton, S Mujib, H Zhang, AK Rahman, J Liu, FY Yue, E Benko, C Kovacs, MA Ostrowski Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9 J. Immunol, 2017;0(0):. 2017 [PMID: 28264968] (Bioassay, Human)	Bioassay	Human
BF Wang, PP Cao, ZC Wang, ZY Li, ZZ Wang, J Ma, B Liao, YK Deng, XB Long, K Xu, H Wang, H Wang, M Zeng, X Lu, Z Liu Interferon-? induced insufficient autophagy contributes to p62-dependent apoptosis of epithelial cells in chronic rhinosinusitis with nasal polyps Allergy, 2017;0(0):. 2017 [PMID: 28258963] (Bioassay, Human)	Bioassay	Human
WY Kuo, L Hwu, CY Wu, JS Lee, CW Chang, RS Liu STAT3/NF-?B-Regulated Lentiviral TK/GCV Suicide Gene Therapy for Cisplatin-Resistant Triple-Negative Breast Cancer Theranostics, 2017;7(3):647-663. 2017 [PMID: 28255357] (Bioassay, Human)	Bioassay	Human
Y Zou, S Zeng, M Huang, Q Qiu, Y Xiao, M Shi, Z Zhan, L Liang, X Yang, H Xu Inhibition of 6-phosphofructo-2-kinase suppresses fibroblast-like synoviocytes- mediated synovial inflammation and joint destruction in rheumatoid arthritis Br. J. Pharmacol, 2017;0(0):. 2017 [PMID: 28239846] (Bioassay, Human)	Bioassay	Human
SR DiNapoli, AM Ortiz, F Wu, K Matsuda, HL Twigg, VM Hirsch, K Knox, JM Brenchley Tissue-resident macrophages can contain replication-competent virus in antiretroviral-naive, SIV-infected Asian macaques JCI Insight, 2017;2(4):e91214. 2017 [PMID: 28239657] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Primate - Macaca mulatta (Rhesus Macaque)
L Israel, Y Wang, K Bulek, E Della Mina, Z Zhang, V Pedergnana, M Chrabieh, NA Lemmens, V Sancho-Shi, M Descatoire, T Lasseau, E Israelsson, L Lorenzo, L Yun, A Belkadi, A Moran, LE Weisman, F Vandenesch, F Batteux, S Weller, M Levin, J Herberg, A Abhyankar, C Prando, Y Itan, WJB van Wamel, C Picard, L Abel, D Chaussabel, X Li, B Beutler, PD Arkwright, JL Casanova, A Puel Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity Cell, 2017;168(5):789-800.e10. 2017 [PMID: 28235196] (Activiation, Human)	Activiation	Human
JS Muhammad, S Nanjo, T Ando, S Yamashita, T Maekita, T Ushijima, Y Tabuchi, T Sugiyama Autophagy Impairment by Helicobacter pylori-induced Methylation Silencing of MAP1LC3Av1 Promotes Gastric Carcinogenesis Int. J. Cancer, 2017;0(0):. 2017 [PMID: 28214334] (Bioassay, Rat)	Bioassay	Rat
NV Sankpal, TP Fleming, PK Sharma, HJ Wiedner, WE Gillanders A double-negative feedback loop between EpCAM and ERK contributes to the regulation of epithelial-mesenchymal transition in cancer Oncogene, 2017;0(0):. 2017 [PMID: 28192403] (Bioassay, Human)	Bioassay	Human
S Kim, J Piao, Y Son, HS Hong Substance P enhances proliferation and paracrine potential of adipose-derived stem cells in�vitro Biochem. Biophys. Res. Commun, 2017;0(0):. 2017 [PMID: 28192115] (Bioassay, Human)	Bioassay	Human
M Tanaka, H Tashiro, B Omer, N Lapteva, J Ando, M Ngo, B Mehta, G Dotti, PR Kinchingto, AM Leen, C Rossig, CM Rooney Vaccination targeting native receptors to enhance the function and proliferation of chimeric antigen receptor (CAR)-modified T cells Clin. Cancer Res, 2017;0(0):. 2017 [PMID: 28183713] (Bioassay, Human)	Bioassay	Human
S Zhu, Q Zhang, X Sun, HJ Zeh, MT Lotze, R Kang, D Tang HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells Cancer Res, 2017;0(0):. 2017 [PMID: 28130223] (Bioassay, Human)	Bioassay	Human
A Smole, D Lain??ek, U Bezeljak, S Horvat, R Jerala A Synthetic Mammalian Therapeutic Gene Circuit for Sensing and Suppressing Inflammation Mol. Ther, 2017;25(1):102-119. 2017 [PMID: 28129106] (Bioassay, Human)	Bioassay	Human
Bo Ra You, Bo Ram Han, Woo Hyun Park Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-? through up-regulation of TNF receptor 1 in lung cancer cells. Oncotarget, 2017;0(0):1949-2553. 2017 [PMID: 28099148] (Bioassay, Human)	Bioassay	Human
AC Lundell, I Nordstr”m, K Andersson, C Lundqvist, E Telemo, S Nava, H Kaipe, A Rudin IFN type I and II induce BAFF secretion from human decidual stromal cells Sci Rep, 2017;7(0):39904. 2017 [PMID: 28057926] (Bioassay, Human)	Bioassay	Human
Anja Kerstein Environmental factor and inflammation-driven alteration of the total peripheral T-cell compartment in granulomatosis with polyangiitis J. Autoimmun, 2016;0(0):. 2016 [PMID: 28040323] (Bioassay, Human)	Bioassay	Human
Eric Chu Bradykinin stimulates protein kinase D-mediated colonic myofibroblast migration via cyclooxygenase-2 and heat shock protein 27 J. Surg. Res, 2016;209(0):191-198. 2016 [PMID: 28032559] (Bioassay, Human)	Bioassay	Human
Martin F Reiner Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression Cardiovasc. Res, 2016;0(0):. 2016 [PMID: 28028070] (Bioassay, Human)	Bioassay	Human
Shailesh Dudhgaonka Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity J. Immunol, 2016;0(0):. 2016 [PMID: 28003376] (Bioassay, Human)	Bioassay	Human
Brijeshkumar S Patel Roflumilast N-oxide in Combination with Formoterol Enhances the Anti-inflammatory Effect of Dexamethasone in ASM Cells Am. J. Respir. Cell Mol. Biol, 2016;0(0):. 2016 [PMID: 27997807] (Bioassay, Human)	Bioassay	Human
Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling Sci Rep, 2016;6(0):39190. 2016 [PMID: 27991524] (Bioassay, Human)	Bioassay	Human
Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency Proc. Natl. Acad. Sci. U.S.A, 2016;0(0):. 2016 [PMID: 27930337] (Bioassay, Human)	Bioassay	Human
Wijtske Annema HDL function is impaired in acute myocardial infarction independent of plasma HDL cholesterol levels J Clin Lipidol, 2016;10(6):1318-1328. 2016 [PMID: 27919348] (Bioassay, Human)	Bioassay	Human
Growth Differentiation Factor-15-Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork Cells Invest. Ophthalmol. Vis. Sci, 2016;57(15):6482-6495. 2016 [PMID: 27918822] (Bioassay, Human)	Bioassay	Human
Benjamin Malard Adsorption as a Contributor for Inflammatory Mediators Removal by Different Hemofiltration Membranes: A Pilot Study Artif Organs, 2016;0(0):. 2016 [PMID: 27911005] (Hemofiltration Procedure, Human)	Hemofiltration Procedure	Human
Prenylated Polyphenols from Clusiaceae and Calophyllaceae with Immunomodulatory Activity on Endothelial Cells PLoS ONE, 2016;11(12):e0167361. 2016 [PMID: 27907087] (Bioassay, Human)	Bioassay	Human
P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor ?1 expression Stem Cell Res Ther, 2016;7(1):175. 2016 [PMID: 27906099] (Bioassay, Human)	Bioassay	Human
Nathalie Castex-Riz Anti-inflammatory and immunomodulatory effects of Aquaphilus dolomiae extract on in vitro models Clin Cosmet Investig Dermatol, 2016;9(0):421-434. 2016 [PMID: 27877060] (Bioassay, Human)	Bioassay	Human
Jong Baeck Lim Identificaiton of Novel Immunogenic Human Papillomavirus Type 16 E7-Specific Epitopes Restricted to HLA-A*33;03 for Cervical Cancer Immunotherapy Yonsei Med. J., 2017;58(1):43-50. 2017 [PMID: 27873494] (Bioassay, Human)	Bioassay	Human
Andrea Todisco Regulation and function of Bone Morphogenetic Protein signaling in colonic injury and inflammation Am. J. Physiol. Gastrointest. Liver Physiol., 2016;0(0):ajpgi.00169.2. 2016 [PMID: 27856416] (Bioassay, Human)	Bioassay	Human
John Deanfield Anti-inflammatory treatment improves high-density lipoprotein function in rheumatoid arthritis Heart, 2016;0(0):. 2016 [PMID: 27852695] (Bioassay, Human)	Bioassay	Human
Robert Sabat MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations Mediators Inflamm., 2016;2016(0):4097574. 2016 [PMID: 27843200] (Bioassay, Human)	Bioassay	Human
Derek N J Hart The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83+-Activated T Cell Population J. Immunol., 2016;0(0):. 2016 [PMID: 27837105] (Bioassay, Human)	Bioassay	Human
R Liu, C Tang, A Shen, H Luo, X Wei, D Zheng, C Sun, Z Li, D Zhu, T Li, Z Wu IL-37 suppresses hepatocellular carcinoma growth by converting pSmad3 signaling from JNK/pSmad3L/c-Myc oncogenic signaling to pSmad3C/P21 tumor-suppressive signaling Oncotarget, 2016;7(51):85079-85096. 2016 [PMID: 27835881] (Bioassay, Human)	Bioassay	Human
Rossana C N Melo Extracellular Microvesicle Production by Human Eosinophils Activated by Inflammatory Stimuli Front Cell Dev Biol, 2016;4(0):117. 2016 [PMID: 27833910] (Bioassay, Human)	Bioassay	Human
Joan W Conaway Role for the MED21-MED7 Hinge in Assembly of the Mediator-RNA Polymerase II Holoenzyme J. Biol. Chem., 2016;0(0):. 2016 [PMID: 27821593] (Bioassay, Human)	Bioassay	Human
Niklas Czeloth Bioequivalence, safety and immunogenicity of BI 695501, an adalimumab biosimilar candidate, compared with the reference biologic in a randomized, double-blind, active-comparator Phase I clinical study (VOLTAIRE�-PK) in healthy subjects Expert Opin Investig Drugs, 2016;0(0):. 2016 [PMID: 27813422] (Bioassay)	Bioassay
Serum YKL-40 as a marker of liver fibrosis in patients with non-alcoholic fatty liver disease Sci Rep, 2016;6(0):35282. 2016 [PMID: 27739482] (Bioassay, Human)	Bioassay	Human
Tissue engineering of acellular vascular grafts capable of somatic growth in young lambs Nat Commun, 2016;7(0):12951. 2016 [PMID: 27676438] (Bioassay, Ovine)	Bioassay	Ovine
Angela P Bastidas-C, Astrid D Bakker, Behrouz Zandieh-D, Cornelis J Kleverlaa, Nathalie Bravenboe, Tim Forouzanf, Jenneke Klein-Nul Cytokines TNF-?, IL-6, IL-17F, and IL-4 Differentially Affect Osteogenic Differentiation of Human Adipose Stem Cells. Stem Cells International, 2016;0(0):1687-966X. 2016 [PMID: 27667999] (Bioassay, Human)	Bioassay	Human
Endothelial Cell Activation is Regulated by Epidermal Growth Factor-Like Domain 7 (Egfl7) during Inflammation J Biol Chem, 2016;0(0):. 2016 [PMID: 27650497] (Bioassay, Human)	Bioassay	Human
Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization Mol Ther Methods Clin Dev, 2016;3(0):16056. 2016 [PMID: 27606349] (Bioassay, Human)	Bioassay	Human
Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17 PLoS ONE, 2016;11(9):e0161759. 2016 [PMID: 27588419] (Bioassay, Human)	Bioassay	Human
Jean-Philippe Pradère, Céline Hernandez, Christiane Koppe, Richard A Friedman, Tom Luedde, Robert F Schwabe Negative regulation of NF-?B p65 activity by serine 536 phosphorylation. Science Signaling, 2016;0(0):1937-9145. 2016 [PMID: 27555662] (Bioassay, Human)	Bioassay	Human
IRAK1, a Target of miR-146b, Reduces Cell Aggressiveness of Human Papillary Thyroid Carcinoma J Clin Endocrinol Metab, 2016;0(0):jc20162276. 2016 [PMID: 27533309] (Bioassay, Human)	Bioassay	Human
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity Cell, 2016;0(0):. 2016 [PMID: 27523608] (Bioassay, Mouse)	Bioassay	Mouse
Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis Cell Death Dis, 2016;7(6):e2287. 2016 [PMID: 27362805] (Bioassay, Human)	Bioassay	Human
Michael A Schmid Mosquito Saliva Increases Endothelial Permeability in the Skin, Immune Cell Migration, and Dengue Pathogenesis during Antibody-Dependent Enhancement PLoS Pathog, 2016;12(6):e1005676. 2016 [PMID: 27310141] (Bioassay, Human)	Bioassay	Human
Interferon-? and Tumor Necrosis Factor-? Polarize Bone Marrow Stromal Cells Uniformly to a Th1 Phenotype Sci Rep, 2016;6(0):26345. 2016 [PMID: 27211104] (Bioassay, Human)	Bioassay	Human
Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells PLoS ONE, 2016;11(5):e0156145. 2016 [PMID: 27203692] (Bioassay, Human)	Bioassay	Human
Mycobacterium massiliense Induces Macrophage Extracellular Traps with Facilitating Bacterial Growth PLoS ONE, 2016;11(5):e0155685. 2016 [PMID: 27191593] (Bioassay, Human)	Bioassay	Human
IL-3 Decreases Cartilage Degeneration by Downregulating Matrix Metalloproteinases and Reduces Joint Destruction in Osteoarthritic Mice J Immunol, 2016;0(0):. 2016 [PMID: 27183574] (Bioassay, Human)	Bioassay	Human
R Yosef, N Pilpel, R Tokarsky-A, A Biran, Y Ovadya, S Cohen, E Vadai, L Dassa, E Shahar, R Condiotti, I Ben-Porath, V Krizhanovs Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL Nat Commun, 2016;7(0):11190. 2016 [PMID: 27048913] (Bioassay, Human)	Bioassay	Human
O Freynet, J Marchal-So, F Jean-Louis, A Mailleux, B Crestani, P Soler, L Michel Human lung fibroblasts may modulate dendritic cell phenotype and function: results from a pilot in vitro study Respir Res, 2016;17(1):36. 2016 [PMID: 27044262] (Bioassay, Human)	Bioassay	Human
MM Halpert, V Konduri, D Liang, Y Chen, JB Wing, S Paust, JM Levitt, WK Decker Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7 Stem Cells Dev., 2016;25(10):774-87. 2016 [PMID: 26979751] (Bioassay, Human)	Bioassay	Human
Y Chen, L Lu, JY Shao Endothelial Surface Protrusion by a Point Force Biophys. J, 2016;110(5):1150-7. 2016 [PMID: 26958891] (Bioassay, Human)	Bioassay	Human
Lu W, Sun J, Yoon J, Zhang Y, Zheng L, Murphy E, Mattson M, Lenardo M Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis. PLoS ONE, 2016;11(1):e0147792. 2016 [PMID: 26807733] (Bioassay, Human)	Bioassay	Human
Guo Z, Zheng L, Liao X, Geller D Up-Regulation of Human Inducible Nitric Oxide Synthase by p300 Transcriptional Complex. PLoS ONE, 2016;11(1):e0146640. 2016 [PMID: 26751080] (Bioassay, Human)	Bioassay	Human
Whitmore L, Hook J, Philiph A, Hilkin B, Bing X, Ahn C, Wong H, Ferguson P, Moreland J A Common Genetic Variant in TLR1 Enhances Human Neutrophil Priming and Impacts Length of Intensive Care Stay in Pediatric Sepsis. J Immunol, 2016;196(3):1376-86. 2016 [PMID: 26729809] (Bioassay, Human)	Bioassay	Human
Lizarraga F, Ceballos-Cancino G, Espinosa M, Vazquez-Santillan K, Maldonado V, Melendez-Zajgla J Tissue Inhibitor of Metalloproteinase-4 Triggers Apoptosis in Cervical Cancer Cells. PLoS ONE, 2015;10(8):e0135929. 2015 [PMID: 26291714]
Zhao Y, Ma C, Wu L, Iwai K, Ashwell J, Oltz E, Ballard D, Jain A CYLD and the NEMO Zinc Finger Regulate Tumor Necrosis Factor Signaling and Early Embryogenesis. J Biol Chem, 2015;290(36):22076-84. 2015 [PMID: 26224629] (Bioassay, Human)	Bioassay	Human
Fairclough L, Stoop A, Negm O, Radford P, Tighe P, Todd I Tumour necrosis factor receptor I blockade shows that TNF-dependent and TNF-independent mechanisms synergise in TNF receptor associated periodic syndrome. Eur J Immunol, 2015;45(10):2937-44. 2015 [PMID: 26202849] (Bioassay, Human)	Bioassay	Human
Divakar S, Ramana Reddy M, Cosenza S, Baker S, Perumal D, Antonelli A, Brody J, Akula B, Parekh S, Premkumar Reddy E Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas. Leukemia, 2016;30(1):86-93. 2016 [PMID: 26174628] (Bioassay, Human)	Bioassay	Human
Onderdijk A, Baerveldt E, Kurek D, Kant M, Florencia E, Debets R, Prens E IL-4 Downregulates IL-1beta and IL-6 and Induces GATA3 in Psoriatic Epidermal Cells: Route of Action of a Th2 Cytokine. J Immunol, 2015;195(4):1744-52. 2015 [PMID: 26170379] (Bioassay, Human)	Bioassay	Human
Watson R, Buck J, Levin L, Winger R, Wang J, Arase H, Muller W Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. J Exp Med, 2015;212(7):1021-41. 2015 [PMID: 26101266] (Bioassay, Human)	Bioassay	Human
Yousef S, Heise J, Lajmi N, Bartels K, Kroger N, Luetkens T, Atanackovic D Cancer-testis antigen SLLP1 represents a promising target for the immunotherapy of multiple myeloma. J Transl Med, 2015;13(0):197. 2015 [PMID: 26088750] (Bioassay, Human)	Bioassay	Human
Kurakula K, Hamers A, van Loenen P, de Vries C 6-Mercaptopurine reduces cytokine and Muc5ac expression involving inhibition of NFkappaB activation in airway epithelial cells. Respir Res, 2015;16(0):73. 2015 [PMID: 26084512] (Bioassay, Human)	Bioassay	Human
Perriard G, Mathias A, Enz L, Canales M, Schluep M, Gentner M, Schaeren-Wiemers N, Du Pasquier R Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes. J Neuroinflammation, 2015;12(0):119. 2015 [PMID: 26077779] (Bioassay, Human)	Bioassay	Human
Miranda A, Funes J, Sanchez N, Limia C, Mesa M, Quezada S, Perez R, de Leon J Oncogenic Transformation Can Orchestrate Immune Evasion and Inflammation in Human Mesenchymal Stem Cells Independently of Extrinsic Immune-Selective Pressure. Cancer Res, 2015;75(15):3032-42. 2015 [PMID: 26069249] (Bioassay, Human)	Bioassay	Human
Boisson B, Laplantine E, Dobbs K, Cobat A, Tarantino N, Hazen M, Lidov H, Hopkins G, DU L, Belkadi A, Chrabieh M, Itan Y, Picard C, Fournet J, Eibel H, Tsitsikov E, Pai S, Abel L, Al-Herz W, Casanova J, Israel A, Notarangelo L Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia. J Exp Med, 2015;212(6):939-51. 2015 [PMID: 26008899] (Bioassay, Human)	Bioassay	Human
Catanzaro D, Rancan S, Orso G, Dall'Acqua S, Brun P, Giron M, Carrara M, Castagliuolo I, Ragazzi E, Caparrotta L, Montopoli M Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage. PLoS ONE, 2015;10(5):e0125375. 2015 [PMID: 25955295]
He Y, Zheng Q, Jiang M, Sun S, Christiansen T, Kassem M, Karsdal M, Bay-Jensen A The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants. PLoS ONE, 2015;10(0):. 2015 [PMID: 25909781] (Bioassay, Bovine)	Bioassay	Bovine
Sommerfelt R, Feuerherm A, Skuland T, Johansen B Cytosolic phospholipase A2 modulates TLR2 signaling in synoviocytes. PLoS ONE, 2015;10(4):e0119088. 2015 [PMID: 25893499] (Bioassay, Human)	Bioassay	Human
Chang , Elizabet, Eckert , Mark A, Ali , M Monsur, Riazifar , Hamidrez, Pone , Egest J, Liu , Linan, Zhao , Weian Facile supermolecular aptamer inhibitors of L-selectin. PLoS ONE, 2015;10(3):e0123034. 2015 [PMID: 25826688] (Bioassay, Human)	Bioassay	Human
Irvin S, Herold B Molecular mechanisms linking high dose medroxyprogesterone with HIV-1 risk. PLoS ONE, 2015;10(3):e0121135. 2015 [PMID: 25798593] (Bioassay, Human)	Bioassay	Human
Rzeniewicz K, Newe A, Rey Gallardo A, Davies J, Holt M, Patel A, Charras G, Stramer B, Molenaar C, Tedder T, Parsons M, Ivetic A L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro. Proc Natl Acad Sci U S A, 2015;112(12):E1461-70. 2015 [PMID: 25775539] (Bioassay, Human)	Bioassay	Human
Liu X, Lai F, Yan X, Jiang C, Guo S, Wang C, Croft A, Tseng H, Wilmott J, Scolyer R, Jin L, Zhang X RIP1 Kinase Is an Oncogenic Driver in Melanoma. Cancer Res, 2015;75(8):1736-48. 2015 [PMID: 25724678] (Bioassay, Human)	Bioassay	Human
Southcombe J, Redman C, Sargent I, Granne I Interleukin-1 family cytokines and their regulatory proteins in normal pregnancy and pre-eclampsia. Clin Exp Immunol, 0;181(3):480-90. 0 [PMID: 25693732] (Bioassay, Human)	Bioassay	Human
Yamaguchi J, Tanaka T, Eto N, Nangaku M Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein delta. Kidney Int, 2015;88(2):262-75. 2015 [PMID: 25692954] (Bioassay, Human)	Bioassay	Human
Wang Y, Tan B, Mu R, Chang Y, Wu M, Tu H, Zhang Y, Guo S, Qin X, Li T, Li W, Li A, Zhang X, Li H Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor kappaB (NF-kappaB) signaling. J Biol Chem, 2015;290(16):10395-405. 2015 [PMID: 25681446] (Bioassay, Human)	Bioassay	Human
Bhardwaj R, Yester J, Singh S, Biswas D, Surace M, Waters M, Hauser K, Yao Z, Boyce B, Kordula T RelB/p50 complexes regulate cytokine-induced YKL-40 expression. J Immunol, 2015;194(6):2862-70. 2015 [PMID: 25681350] (Bioassay, Human)	Bioassay	Human
Guerrero A, Iglesias C, Raguz S, Floridia E, Gil J, Pombo C, Zalvide J The cerebral cavernous malformation 3 gene is necessary for senescence induction. Aging Cell, 2015;14(2):274-83. 2015 [PMID: 25655101] (Bioassay, Human)	Bioassay	Human
Rider C, Shah S, Miller-Larsson A, Giembycz M, Newton R Cytokine-induced loss of glucocorticoid function: effect of kinase inhibitors, long-acting beta(2)-adrenoceptor [corrected] agonist and glucocorticoid receptor ligands. PLoS ONE, 2015;10(1):e0116773. 2015 [PMID: 25625944] (Bioassay, Human)	Bioassay	Human
Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells. Invest Ophthalmol Vis Sci, 2015;56(2):1051-62. 2015 [PMID: 25604685] (Bioassay, Human)	Bioassay	Human
Rousseau M, Belleannee C, Duchez A, Cloutier N, Levesque T, Jacques F, Perron J, Nigrovic P, Dieude M, Hebert M, Gelb M, Boilard E Detection and quantification of microparticles from different cellular lineages using flow cytometry. Evaluation of the impact of secreted phospholipase A2 on microparticle assessment. PLoS ONE, 2015;10(1):e0116812. 2015 [PMID: 25587983] (Bioassay, Human)	Bioassay	Human
Deng Z, Gomez T, Osborne D, Phillips-Krawczak C, Zhang J, Billadeau D Nuclear FAM21 participates in NF-kappaB-dependent gene regulation in pancreatic cancer cells. J Cell Sci, 2015;128(2):373-84. 2015 [PMID: 25431135] (Bioassay, Human)	Bioassay	Human
Muller I, Beissert S, Kulms D Anti-apoptotic NF-kappaB and "gain of function" mutp53 in concert act pro-apoptotic in response to UVB+IL-1 via enhanced TNF production. J Invest Dermatol, 2015;135(3):851-60. 2015 [PMID: 25380350] (Bioassay, Human)	Bioassay	Human
Lam , Sharon, Sung , Julia, Cruz , Conrad, Castillo-Caro , Paul, Ngo , Minhtran, Garrido , Carolina, Kuruc , Joann, Archin , Nancie, Rooney , Cliona, Margolis , David, Bollard , Catherin Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy. Mol Ther, 2015;23(2):387-95. 2015 [PMID: 25366030] (Bioassay, Human)	Bioassay	Human
Lee S, Lee J, Shin K, Kim D, Kim Y, Bae Y, Jung J Role of transforming growth factor-activated kinase-1 on tumor necrosis factor-alpha actions in human adipose tissue-derived stromal cells. Stem Cells Dev, 2015;24(7):836-45. 2015 [PMID: 25350220] (Bioassay, Human)	Bioassay	Human
Chan C, Fang C, Qiao Y, Yarilina A, Prinjha R, Ivashkiv L BET bromodomain inhibition suppresses transcriptional responses to cytokine-Jak-STAT signaling in a gene-specific manner in human monocytes. Eur J Immunol, 2015;45(1):287-97. 2015 [PMID: 25345375] (Bioassay, Human)	Bioassay	Human
Leslie J, Huang S, Opp J, Nagy M, Kobayashi M, Young V, Spence J Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function. Infect Immun, 2015;83(1):138-45. 2015 [PMID: 25312952] (Bioassay, Human)	Bioassay	Human
Sato J, Kinugasa M, Satomi-Kobayashi S, Hatakeyama K, Knox A, Asada Y, Wierman M, Hirata K, Rikitake Y Family with sequence similarity 5, member C (FAM5C) increases leukocyte adhesion molecules in vascular endothelial cells: implication in vascular inflammation. PLoS ONE, 2014;9(9):e107236. 2014 [PMID: 25251368] (Bioassay, Human)	Bioassay	Human
Normanton M, Alvarenga H, Hamerschlak N, Ribeiro A, Kondo A, Rizzo L, Marti L Interleukin 7 plays a role in T lymphocyte apoptosis inhibition driven by mesenchymal stem cell without favoring proliferation and cytokines secretion. PLoS ONE, 2014;9(9):e106673. 2014 [PMID: 25184791] (Bioassay, Human)	Bioassay	Human
De Simone V, Franze E, Ronchetti G, Colantoni A, Fantini M, Di Fusco D, Sica G, Sileri P, MacDonald T, Pallone F, Monteleone G, Stolfi C Th17-type cytokines, IL-6 and TNF-alpha synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene, 2015;34(27):3493-503. 2015 [PMID: 25174402] (Bioassay, Human)	Bioassay	Human
Kubo T, Kamekura R, Kumagai A, Kawata K, Yamashita K, Mitsuhashi Y, Kojima T, Sugimoto K, Yoneta A, Sumikawa Y, Yamashita T, Sato N, Himi T, Ichimiya S DeltaNp63 controls a TLR3-mediated mechanism that abundantly provides thymic stromal lymphopoietin in atopic dermatitis. PLoS ONE, 2014;9(8):e105498. 2014 [PMID: 25171086] (Bioassay, Human)	Bioassay	Human
Ohkawara H, Ishibashi T, Sugimoto K, Ikeda K, Ogawa K, Takeishi Y Membrane type 1-matrix metalloproteinase/Akt signaling axis modulates TNF-alpha-induced procoagulant activity and apoptosis in endothelial cells. PLoS ONE, 2014;9(8):e105697. 2014 [PMID: 25162582] (Bioassay, Human)	Bioassay	Human
Kim S, Chung H, Lee K, Lim J Identification of novel epitopes from human papillomavirus type 18 E7 that can sensitize PBMCs of multiple HLA class I against human cervical cancer. J Transl Med, 2014;12(0):229. 2014 [PMID: 25141788] (Bioassay, Human)	Bioassay	Human
Salzano S, Checconi P, Hanschmann E, Lillig C, Bowler L, Chan P, Vaudry D, Mengozzi M, Coppo L, Sacre S, Atkuri K, Sahaf B, Herzenberg L, Herzenberg L, Mullen L, Ghezzi P Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal. Proc Natl Acad Sci U S A, 2014;111(33):12157-62. 2014 [PMID: 25097261] (Bioassay, Mouse)	Bioassay	Mouse
Bailon E, Ugarte-Berzal E, Amigo-Jimenez I, Van den Steen P, Opdenakker G, Garcia-Marco J, Garcia-Pardo A Overexpression of progelatinase B/proMMP-9 affects migration regulatory pathways and impairs chronic lymphocytic leukemia cell homing to bone marrow and spleen. J Leukoc Biol, 2014;96(2):185-99. 2014 [PMID: 25080557] (Not Specified, Human)	Not Specified	Human
Sehgal K, Ragheb R, Fahmy T, Dhodapkar M, Dhodapkar K Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk. J Immunol, 2014;193(5):2297-305. 2014 [PMID: 25080481] (Bioassay, Human)	Bioassay	Human
O'Hara A, Simpson J, Morin P, Loveridge C, Williams A, Novo S, Stark L p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-kappaB subunit. J Cell Sci, 2014;127(0):3659-65. 2014 [PMID: 25074812] (Bioassay, Human)	Bioassay	Human
Ji , Weidong, Yang , Mei, Praggastis , Alexandr, Li , Yonghao, Zhou , Huanjiao, He , Yun, Ghazvinian , Roxanne, Cincotta , Dylan J, Rice , Kevin P, Min , Wang Carbamoylating activity associated with the activation of the antitumor agent laromustine inhibits angiogenesis by inducing ASK1-dependent endothelial cell death. PLoS ONE, 2014;9(7):e103224. 2014 [PMID: 25068797] (Bioassay, Bovine)	Bioassay	Bovine
Chattopadhyay A, Hood B, Conrads T, Redner R Extrinsic apoptosis is impeded by direct binding of the APL fusion protein NPM-RAR to TRADD. Mol Cancer Res, 2014;12(9):1283-91. 2014 [PMID: 25033841] (Bioassay, Human)	Bioassay	Human
Guedes R, Csizmadia E, Moll H, Ma A, Ferran C, da Silva C A20 deficiency causes spontaneous neuroinflammation in mice. J Neuroinflammation, 2014;11(0):122. 2014 [PMID: 25026958] (Stimulation, Mouse)	Stimulation	Mouse
Wu L, Wang C, Boisson B, Misra S, Rayman P, Finke J, Puel A, Casanova J, Li X The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling. J Immunol, 2014;193(4):1590-9. 2014 [PMID: 25024377] (Bioassay, Human)	Bioassay	Human
Rabeony H, Petit-Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, Jegou J, Guillet G, Huguier V, Lecron J, Bernard F, Morel F Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1alpha, TNFalpha and oncostatin M. PLoS ONE, 2014;9(7):e101937. 2014 [PMID: 25010647] (Bioassay, Human)	Bioassay	Human
Jin H, Lee W, Eun S, Jung J, Park H, Kim G, Choi Y, Ryu C, Jung J, Hong S, Shin S, Kim H Morin, a flavonoid from Moraceae, suppresses growth and invasion of the highly metastatic breast cancer cell line MDA-MB231 partly through suppression of the Akt pathway. Int J Oncol, 2014;45(4):1629-37. 2014 [PMID: 24993541] (Bioassay, Human)	Bioassay	Human
Lewis , Nuruddee, Patnaude , Lori A, Pelletier , Josephin, Souza , Donald J, Lukas , Susan M, King , F James, Hill , Jonathan, Stefanopoulos , Dimitria, Ryan , Kelli, Desai , Sudha, Skow , Donna, Kauschke , Stefan G, Broermann , Andre, Kuzmich , Daniel, Harcken , Christia, Hickey , Eugene R, Modis , Louise K A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo. PLoS ONE, 2014;9(6):e100883. 2014 [PMID: 24967665] (Bioassay, Human)	Bioassay	Human
Chiang , En-Pei I, Tsai , Shu-Yao, Kuo , Yueh-Hsi, Pai , Man-Hui, Chiu , Hsi-Lin, Rodriguez , Raymond, Tang , Feng-Yao Caffeic acid derivatives inhibit the growth of colon cancer: involvement of the PI3-K/Akt and AMPK signaling pathways. PLoS ONE, 2014;9(6):e99631. 2014 [PMID: 24960186] (Bioassay, Human)	Bioassay	Human
Kastrati I, Canestrari E, Frasor J PHLDA1 expression is controlled by an estrogen receptor-NFkappaB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres. Oncogene, 2015;34(18):2309-16. 2015 [PMID: 24954507] (Bioassay, Human)	Bioassay	Human
Shindo Y, Hazama S, Maeda Y, Matsui H, Iida M, Suzuki N, Yoshimura K, Ueno T, Yoshino S, Sakai K, Suehiro Y, Yamasaki T, Hinoda Y, Oka M Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer. J Transl Med, 2014;12(0):175. 2014 [PMID: 24947606] (Bioassay, Human)	Bioassay	Human
Mimura N, Hideshima T, Shimomura T, Suzuki R, Ohguchi H, Rizq O, Kikuchi S, Yoshida Y, Cottini F, Jakubikova J, Cirstea D, Gorgun G, Minami J, Tai Y, Richardson P, Utsugi T, Iwama A, Anderson K Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition. Cancer Res, 2014;74(16):4458-69. 2014 [PMID: 24934808] (Bioassay, Human)	Bioassay	Human
Cubbon R, Yuldasheva N, Viswambharan H, Mercer B, Baliga V, Stephen S, Askham J, Sukumar P, Skromna A, Mughal R, Walker A, Bruns A, Bailey M, Galloway S, Imrie H, Gage M, Rakobowchuk M, Li J, Porter K, Ponnambalam S, Wheatcroft S, Beech D, Kearney M Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential. Stem Cells, 2014;32(10):2714-23. 2014 [PMID: 24916783] (Bioassay, Human)	Bioassay	Human
Volpe E, Pattarini L, Martinez-Cingolani C, Meller S, Donnadieu M, Bogiatzi S, Fernandez M, Touzot M, Bichet J, Reyal F, Paronetto M, Chiricozzi A, Chimenti S, Nasorri F, Cavani A, Kislat A, Homey B, Soumelis V Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis. J Allergy Clin Immunol, 2014;134(2):373-81. 2014 [PMID: 24910175] (Bioassay, Human)	Bioassay	Human
Zhao Y, Xiao X, Frank S, Lin H, Xia Y Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-alpha, and IL-1beta. Am J Physiol Endocrinol Metab, 2014;307(2):E186-98. 2014 [PMID: 24895283] (Bioassay, Human)	Bioassay	Human
Tengroth L, Millrud C, Kvarnhammar A, Kumlien Georen S, Latif L, Cardell L Functional effects of Toll-like receptor (TLR)3, 7, 9, RIG-I and MDA-5 stimulation in nasal epithelial cells. PLoS ONE, 2014;9(6):e98239. 2014 [PMID: 24886842] (Bioassay, Human)	Bioassay	Human
Kim , Dae Won, Zloza , Andrew, Broucek , Joseph, Schenkel , Jason M, Ruby , Carl, Samaha , Georges, Kaufman , Howard L Interleukin-2 alters distribution of CD144 (VE-cadherin) in endothelial cells. J Transl Med, 2014;12(0):113. 2014 [PMID: 24885155] (Bioassay, Human)	Bioassay	Human
Schafer P, Parton A, Capone L, Cedzik D, Brady H, Evans J, Man H, Muller G, Stirling D, Chopra R Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity. Cell Signal, 2014;26(9):2016-29. 2014 [PMID: 24882690] (Bioassay, Human)	Bioassay	Human
Montespan F, Deschaseaux F, Sensebe L, Carosella E, Rouas-Freiss N Osteodifferentiated mesenchymal stem cells from bone marrow and adipose tissue express HLA-G and display immunomodulatory properties in HLA-mismatched settings: implications in bone repair therapy. J Immunol Res, 2014;2014(0):230346. 2014 [PMID: 24877156] (Bioassay, Human)	Bioassay	Human
Backman S, Kollara A, Haw R, Stein L, Brown T Glucocorticoid-induced reversal of interleukin-1beta-stimulated inflammatory gene expression in human oviductal cells. PLoS ONE, 2014;9(5):e97997. 2014 [PMID: 24848801] (Bioassay, Human)	Bioassay	Human
Cupi M, Sarra M, Marafini I, Monteleone I, Franze E, Ortenzi A, Colantoni A, Sica G, Sileri P, Rosado M, Carsetti R, MacDonald T, Pallone F, Monteleone G Plasma cells in the mucosa of patients with inflammatory bowel disease produce granzyme B and possess cytotoxic activities. J Immunol, 2014;192(12):6083-91. 2014 [PMID: 24835396] (Bioassay, Human)	Bioassay	Human
Herr F, Lemoine R, Gouilleux F, Meley D, Kazma I, Heraud A, Velge-Roussel F, Baron C, Lebranchu Y IL-2 phosphorylates STAT5 to drive IFN-gamma production and activation of human dendritic cells. J Immunol, 2014;192(12):5660-70. 2014 [PMID: 24829413] (Bioassay, Human)	Bioassay	Human
You D, Park C, Lee H, Moon M, Kang J, Lee C, Oh S, Ahn C, Seong J, Hwang J A splicing variant of NME1 negatively regulates NF-kappaB signaling and inhibits cancer metastasis by interacting with IKKbeta. J Biol Chem, 2014;289(25):17709-20. 2014 [PMID: 24811176] (Bioassay, Human)	Bioassay	Human
Catanzaro J, Sheshadri N, Pan J, Sun Y, Shi C, Li J, Powers R, Crawford H, Zong W Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4. Nat Commun, 2014;5(0):3729. 2014 [PMID: 24759783] (Bioassay, Human)	Bioassay	Human
Harris D, Bandyopadhyay S, Maxwell T, Willard B, DiCorleto P Tumor necrosis factor (TNF)-alpha induction of CXCL10 in endothelial cells requires protein arginine methyltransferase 5 (PRMT5)-mediated nuclear factor (NF)-kappaB p65 methylation. J Biol Chem, 2014;289(22):15328-39. 2014 [PMID: 24753255] (Bioassay, Human)	Bioassay	Human
Singer B, Opp L, Heinrich A, Schreiber F, Binding-Liermann R, Berrocal-Almanza L, Heyl K, Muller M, Weimann A, Zweigner J, Slevogt H Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses. PLoS ONE, 2014;9(4):e94106. 2014 [PMID: 24743304] (Bioassay, Human)	Bioassay	Human
Mambetsariev I, Tian Y, Wu T, Lavoie T, Solway J, Birukov K, Birukova A Stiffness-activated GEF-H1 expression exacerbates LPS-induced lung inflammation. PLoS ONE, 2014;9(4):e92670. 2014 [PMID: 24739883] (Bioassay, Human)	Bioassay	Human
Ugarte-Berzal E, Bailon E, Amigo-Jimenez I, Albar J, Garcia-Marco J, Garcia-Pardo A A novel CD44-binding peptide from the pro-matrix metalloproteinase-9 hemopexin domain impairs adhesion and migration of chronic lymphocytic leukemia (CLL) cells. J Biol Chem, 2014;289(22):15340-9. 2014 [PMID: 24739387] (Bioassay, Human)	Bioassay	Human
Singh , Meera V, Davidson , Donna C, Jackson , Joseph W, Singh , Vir B, Silva , Jharon, Ramirez , Servio H, Maggirwar , Sanjay B Characterization of platelet-monocyte complexes in HIV-1-infected individuals: possible role in HIV-associated neuroinflammation. J Immunol, 2014;192(10):4674-84. 2014 [PMID: 24729609] (Bioassay, Human)	Bioassay	Human
Liu J, Ren Y, Kang L, Zhang L Overexpression of CCN3 inhibits inflammation and progression of atherosclerosis in apolipoprotein E-deficient mice. PLoS ONE, 2014;9(4):e94912. 2014 [PMID: 24722330] (Bioassay, Human)	Bioassay	Human
Beigel F, Friedrich M, Probst C, Sotlar K, Goke B, Diegelmann J, Brand S Oncostatin M mediates STAT3-dependent intestinal epithelial restitution via increased cell proliferation, decreased apoptosis and upregulation of SERPIN family members. PLoS ONE, 2014;9(4):e93498. 2014 [PMID: 24710357] (Western Blot, N/A)	Western Blot	N/A
Hamada K, Osaka M, Yoshida M Cell density impacts epigenetic regulation of cytokine-induced E-selectin gene expression in vascular endothelium. PLoS ONE, 2014;9(4):e90502. 2014 [PMID: 24690766] (Bioassay, Human)	Bioassay	Human
Negm O, Mannsperger H, McDermott E, Drewe E, Powell R, Todd I, Fairclough L, Tighe P A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS). Eur J Immunol, 2014;44(7):2096-110. 2014 [PMID: 24668260] (Bioassay, Human)	Bioassay	Human
Ohlsson S, Ohlsson S, Soderberg D, Gunnarsson L, Pettersson A, Segelmark M, Hellmark T Neutrophils from vasculitis patients exhibit an increased propensity for activation by anti-neutrophil cytoplasmic antibodies. Clin Exp Immunol, 2014;176(3):363-72. 2014 [PMID: 24666336] (Bioassay, Human)	Bioassay	Human
Du J, An R, Chen L, Shen Y, Chen Y, Cheng L, Jiang Z, Zhang A, Yu L, Chu D, Shen Y, Luo Q, Chen H, Wan L, Li M, Xu X, Shen J Toxoplasma gondii virulence factor ROP18 inhibits the host NF-kappaB pathway by promoting p65 degradation. J Biol Chem, 2014;289(18):12578-92. 2014 [PMID: 24648522] (Bioassay, Human)	Bioassay	Human
Rahman M, Alkhouri H, Tang F, Che W, Ge Q, Ammit A Sphingosine 1-phosphate induces neutrophil chemoattractant IL-8: repression by steroids. PLoS ONE, 2014;9(3):e92466. 2014 [PMID: 24647471] (Bioassay, Human)	Bioassay	Human
Hsiao B, Chang T, Wu I, Chen M Rad GTPase inhibits the NFkappaB pathway through interacting with RelA/p65 to impede its DNA binding and target gene transactivation. Cell Signal, 2014;26(7):1437-44. 2014 [PMID: 24632303]
You B, Park W Suberoylanilide hydroxamic acid-induced HeLa cell death is closely correlated with oxidative stress and thioredoxin 1 levels. Int J Oncol, 2014;44(5):1745-55. 2014 [PMID: 24626405] (Bioassay, Human)	Bioassay	Human
Lopez-Ramirez M, Wu D, Pryce G, Simpson J, Reijerkerk A, King-Robson J, Kay O, de Vries H, Hirst M, Sharrack B, Baker D, Male D, Michael G, Romero I MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation. FASEB J, 2014;28(6):2551-65. 2014 [PMID: 24604078] (Bioassay, Human)	Bioassay	Human
Weng Z, Patel A, Vasiadi M, Therianou A, Theoharides T Luteolin inhibits human keratinocyte activation and decreases NF-kappaB induction that is increased in psoriatic skin. PLoS ONE, 2014;9(2):e90739. 2014 [PMID: 24587411] (Bioassay, Human)	Bioassay	Human
Kankaanranta H, Ilmarinen P, Zhang X, Adcock I, Lahti A, Barnes P, Giembycz M, Lindsay M, Moilanen E Tumour necrosis factor-alpha regulates human eosinophil apoptosis via ligation of TNF-receptor 1 and balance between NF-kappaB and AP-1. PLoS ONE, 2014;9(2):e90298. 2014 [PMID: 24587316] (Bioassay, Human)	Bioassay	Human
Lessey-Morillon E, Osborne L, Monaghan-Benson E, Guilluy C, O'Brien E, Superfine R, Burridge K The RhoA guanine nucleotide exchange factor, LARG, mediates ICAM-1-dependent mechanotransduction in endothelial cells to stimulate transendothelial migration. J Immunol, 2014;192(7):3390-8. 2014 [PMID: 24585879] (Bioassay, Human)	Bioassay	Human
Zhao N, Wang R, Zhou L, Zhu Y, Gong J, Zhuang S MicroRNA-26b suppresses the NF-kappaB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3. Mol Cancer, 2014;13(0):35. 2014 [PMID: 24565101] (Bioassay, Human)	Bioassay	Human
Magri G, Miyajima M, Bascones S, Mortha A, Puga I, Cassis L, Barra C, Comerma L, Chudnovskiy A, Gentile M, Llige D, Cols M, Serrano S, Arostegui J, Juan M, Yague J, Merad M, Fagarasan S, Cerutti A Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells. Nat Immunol, 2014;15(4):354-64. 2014 [PMID: 24562309] (Bioassay, Human)	Bioassay	Human
Proenca-Ferreira R, Brugnerotto A, Garrido V, Dominical V, Vital D, Ribeiro M, dos Santos M, Traina F, Olalla-Saad S, Costa F, Conran N Endothelial activation by platelets from sickle cell anemia patients. PLoS ONE, 2014;9(2):e89012. 2014 [PMID: 24551209] (Bioassay, Human)	Bioassay	Human
Llop-Guevara A, Chu D, Walker T, Goncharova S, Fattouh R, Silver J, Moore C, Xie J, O'Byrne P, Coyle A, Kolbeck R, Humbles A, Stampfli M, Jordana M A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure. PLoS ONE, 2013;9(2):e88714. 2013 [PMID: 24551140] (Bioassay, Human)	Bioassay	Human
Jung C, Lee M, Kang Y, Lee Y, Yoon H, Kang S, Lee W, Park J Vaspin inhibits cytokine-induced nuclear factor-kappa B activation and adhesion molecule expression via AMP-activated protein kinase activation in vascular endothelial cells. Cardiovasc Diabetol, 2014;13(0):41. 2014 [PMID: 24517399] (Bioassay, Human)	Bioassay	Human
Tannheimer S, Sorensen E, Cui Z, Kim M, Patel L, Baker W, Phillips G, Wright C, Salmon M The in vitro pharmacology of GS-5759, a novel bifunctional phosphodiesterase 4 inhibitor and long acting beta2-adrenoceptor agonist. J Pharmacol Exp Ther, 2014;349(1):85-93. 2014 [PMID: 24513870] (Bioassay, Human)	Bioassay	Human
Tsai C, Chen W, Hsieh H, Chi P, Hsiao L, Yang C TNF-alpha induces matrix metalloproteinase-9-dependent soluble intercellular adhesion molecule-1 release via TRAF2-mediated MAPKs and NF-kappaB activation in osteoblast-like MC3T3-E1 cells. J Biomed Sci, 2014;21(0):12. 2014 [PMID: 24502696] (Bioassay, Mouse)	Bioassay	Mouse
Parlato M, Souza-Fonseca-Guimaraes F, Philippart F, Misset B, Adib-Conquy M, Cavaillon J CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis. J Immunol, 2014;192(5):2449-59. 2014 [PMID: 24501201] (Bioassay, Human)	Bioassay	Human
Milwid , Jack M, Elman , Jessica, Li , Matthew, Shen , Keyue, Manrai , Arjun, Gabow , Aaron, Yarmush , Joshua, Jiao , Yunxin, Fletcher , Anne, Lee , Jungwoo, Cima , Michael, Yarmush , Martin L, Parekkadan , Biju Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators. Mol Ther, 2014;22(5):999-1007. 2014 [PMID: 24496384] (Bioassay, Human)	Bioassay	Human
Morlino G, Barreiro O, Baixauli F, Robles-Valero J, Gonzalez-Granado J, Villa-Bellosta R, Cuenca J, Sanchez-Sorzano C, Veiga E, Martin-Cofreces N, Sanchez-Madrid F Miro-1 links mitochondria and microtubule Dynein motors to control lymphocyte migration and polarity. Mol Cell Biol, 2014;34(8):1412-26. 2014 [PMID: 24492963] (Bioassay, Human)	Bioassay	Human
Evans H, Roostalu U, Walter G, Gullick N, Frederiksen K, Roberts C, Sumner J, Baeten D, Gerwien J, Cope A, Geissmann F, Kirkham B, Taams L TNF-alpha blockade induces IL-10 expression in human CD4+ T cells. Nat Commun, 2014;5(0):3199. 2014 [PMID: 24492460] (Bioassay, Human)	Bioassay	Human
Lo H, Lai T, Li C, Wu W TNF-alpha induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways. Acta Pharmacol Sin, 2014;35(3):339-50. 2014 [PMID: 24487964]
Haseeb A, Makki M, Haqqi T Modulation of ten-eleven translocation 1 (TET1), Isocitrate Dehydrogenase (IDH) expression, alpha-Ketoglutarate (alpha-KG), and DNA hydroxymethylation levels by interleukin-1beta in primary human chondrocytes. J Biol Chem, 2014;289(10):6877-85. 2014 [PMID: 24469454] (Bioassay, Human)	Bioassay	Human
Liu F, Wu X, Zhang Y, Wang Y, Jiang F TRAIL/DR5 signaling promotes macrophage foam cell formation by modulating scavenger receptor expression. PLoS ONE, 2014;9(1):e87059. 2014 [PMID: 24466325] (Bioassay, Human)	Bioassay	Human
van Bergen , Cornelis, Verdegaal , Elisabet, Honders , M Wilhel, Hoogstraten , Conny, Steijn-van Tol , A Q M Je, de Quartel , Linda, de Jong , Joan, Meyering , Maaike, Falkenburg , J H Fred, Griffioen , Marieke, Osanto , Susanne Durable remission of renal cell carcinoma in conjuncture with graft versus host disease following allogeneic stem cell transplantation and donor lymphocyte infusion: rule or exception? PLoS ONE, 2014;9(1):e85198. 2014 [PMID: 24454818] (Bioassay, Human)	Bioassay	Human
Liu C, Chen X, Yang L, Kisseleva T, Brenner D, Seki E Transcriptional repression of the transforming growth factor beta (TGF-beta) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor kappaB (NF-kappaB) p50 enhances TGF-beta signaling in hepatic stellate cells. J Biol Chem, 2014;289(10):7082-91. 2014 [PMID: 24448807] (Bioassay, Human)	Bioassay	Human
Sawada H, Saito T, Nickel N, Alastalo T, Glotzbach J, Chan R, Haghighat L, Fuchs G, Januszyk M, Cao A, Lai Y, Perez V, Kim Y, Wang L, Chen P, Spiekerkoetter E, Mitani Y, Gurtner G, Sarnow P, Rabinovitch M Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension. J Exp Med, 2013;211(2):263-80. 2013 [PMID: 24446489] (Bioassay, Human)	Bioassay	Human
Hu M, Yang Q, Zhang J, Liu S, Zhang Y, Lin H, Huang Z, Wang Y, Zhang X, Zhong B, Shu H TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A, 2014;111(4):1509-14. 2014 [PMID: 24434549] (Bioassay, Human)	Bioassay	Human
Ahmad T, Mukherjee S, Pattnaik B, Kumar M, Singh S, Kumar M, Rehman R, Tiwari B, Jha K, Barhanpurkar A, Wani M, Roy S, Mabalirajan U, Ghosh B, Agrawal A Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy. EMBO J, 2014;33(9):994-1010. 2014 [PMID: 24431222] (Bioassay, Human)	Bioassay	Human
Tilstra J, Gaddy D, Zhao J, Dave S, Niedernhofer L, Plevy S, Robbins P Pharmacologic IKK/NF-kappaB inhibition causes antigen presenting cells to undergo TNFalpha dependent ROS-mediated programmed cell death. Sci Rep, 2014;4(0):3631. 2014 [PMID: 24406986] (Bioassay, Human)	Bioassay	Human
Chinnadurai R, Copland I, Patel S, Galipeau J IDO-independent suppression of T cell effector function by IFN-gamma-licensed human mesenchymal stromal cells. J Immunol, 2014;192(4):1491-501. 2014 [PMID: 24403533] (Bioassay, Human)	Bioassay	Human
Suzuki , Hitoshi, Raska , Milan, Yamada , Koshi, Moldoveanu , Zina, Julian , Bruce A, Wyatt , Robert J, Tomino , Yasuhiko, Gharavi , Ali G, Novak , Jan Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes. J Biol Chem, 2014;289(8):5330-9. 2014 [PMID: 24398680] (Bioassay, Human)	Bioassay	Human
Narayanan R, Yepuru M, Coss C, Wu Z, Bauler M, Barrett C, Mohler M, Wang Y, Kim J, Snyder L, He Y, Levy N, Miller D, Dalton J Discovery and preclinical characterization of novel small molecule TRK and ROS1 tyrosine kinase inhibitors for the treatment of cancer and inflammation. PLoS ONE, 2013;8(12):e83380. 2013 [PMID: 24386191] (Bioassay, Human)	Bioassay	Human
Fiorcari S, Brown W, McIntyre B, Estrov Z, Maffei R, O'Brien S, Sivina M, Hoellenriegel J, Wierda W, Keating M, Ding W, Kay N, Lannutti B, Marasca R, Burger J The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells. PLoS ONE, 2013;8(12):e83830. 2013 [PMID: 24376763] (Bioassay, Human)	Bioassay	Human
Li W, Okuda A, Yamamoto H, Yamanishi K, Terada N, Yamanishi H, Tanaka Y, Okamura H Regulation of development of CD56 bright CD11c + NK-like cells with helper function by IL-18. PLoS ONE, 2013;8(12):e82586. 2013 [PMID: 24376549] (Not Specified, Human)	Not Specified	Human
Nomura T, Aoyama M, Waguri-Nagaya Y, Goto Y, Suzuki M, Miyazawa K, Asai K, Goto S Tumor necrosis factor stimulates osteoclastogenesis from human bone marrow cells under hypoxic conditions. Exp Cell Res, 2014;321(2):167-77. 2014 [PMID: 24360989] (Bioassay, Human)	Bioassay	Human
Dalli , Jesmond, Norling , Lucy V, Montero-Melendez , Trinidad, Federici Canova , Donata, Lashin , Hazem, Pavlov , Anton M, Sukhorukov , Gleb B, Hinds , Charles, Perretti , Mauro Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. EMBO Mol Med, 2014;6(1):27-42. 2014 [PMID: 24357647] (Bioassay, Human)	Bioassay	Human
Sommerfelt R, Feuerherm A, Jones K, Johansen B Cytosolic phospholipase A2 regulates TNF-induced production of joint destructive effectors in synoviocytes. PLoS ONE, 2013;8(12):e83555. 2013 [PMID: 24349530] (Bioassay, Human)	Bioassay	Human
Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque S, Ghanbari A, Joe-Njoku I, Giuffrida P, Rovedatti L, Geginat J, Corazza G, MacDonald T Absence of a role for interleukin-13 in inflammatory bowel disease. Eur J Immunol, 2014;44(2):370-85. 2014 [PMID: 24338958] (Bioassay, Human)	Bioassay	Human
Cheng X, He P, Lee T, Yao H, Li R, Shen Y High activities of BACE1 in brains with mild cognitive impairment. Am J Pathol, 2014;184(1):141-7. 2014 [PMID: 24332014] (Bioassay, Human)	Bioassay	Human
Lauridsen H, Pober J, Gonzalez A A composite model of the human postcapillary venule for investigation of microvascular leukocyte recruitment. FASEB J, 2014;28(3):1166-80. 2014 [PMID: 24297702] (Bioassay, Human)	Bioassay	Human
Zhou Y, Tanaka T, Sugiyama N, Yokoyama S, Kawasaki Y, Sakuma T, Ishihama Y, Saiki I, Sakurai H p38-Mediated phosphorylation of Eps15 endocytic adaptor protein. FEBS Lett, 2014;588(1):131-7. 2014 [PMID: 24269888] (Bioassay, Human)	Bioassay	Human
McFarland B, Hong S, Rajbhandari R, Twitty G, Gray G, Yu H, Benveniste E, Nozell S NF-kappaB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma. PLoS ONE, 2013;8(11):e78728. 2013 [PMID: 24244348] (Cell Culture, Human)	Cell Culture	Human
Cucchiarini M, Madry H, Terwilliger E Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis. J Cell Mol Med, 2014;18(1):115-24. 2014 [PMID: 24237934] (Bioassay, Human)	Bioassay	Human
Mercier S, Donaghy H, Botting R, Turville S, Harman A, Nasr N, Ji H, Kusebauch U, Mendoza L, Shteynberg D, Sandgren K, Simpson R, Moritz R, Cunningham A The microvesicle component of HIV-1 inocula modulates dendritic cell infection and maturation and enhances adhesion to and activation of T lymphocytes. PLoS Pathog, 2013;9(10):e1003700. 2013 [PMID: 24204260] (Bioassay, Human)	Bioassay	Human
Sidney L, Kirkham G, Buttery L Comparison of osteogenic differentiation of embryonic stem cells and primary osteoblasts revealed by responses to IL-1beta, TNF-alpha, and IFN-gamma. Stem Cells Dev, 2014;23(6):605-17. 2014 [PMID: 24192281] (Bioassay, Mouse)	Bioassay	Mouse
Gansler J, Preissner K, Fischer S Influence of proinflammatory stimuli on the expression of vascular ribonuclease 1 in endothelial cells. FASEB J, 2014;28(2):752-60. 2014 [PMID: 24174426] (Bioassay, Human)	Bioassay	Human
Duverger , Alexandr, Wolschendorf , Frank, Anderson , Joshua C, Wagner , Frederic, Bosque , Alberto, Shishido , Takao, Jones , Jennifer, Planelles , Vicente, Willey , Christop, Cron , Randall, Kutsch , Olaf Kinase control of latent HIV-1 infection: PIM-1 kinase as a major contributor to HIV-1 reactivation. J Virol, 2014;88(1):364-76. 2014 [PMID: 24155393] (Bioassay, Human)	Bioassay	Human
Fraietta J, Mueller Y, Yang G, Boesteanu A, Gracias D, Do D, Hope J, Kathuria N, McGettigan S, Lewis M, Giavedoni L, Jacobson J, Katsikis P Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection. PLoS Pathog, 2013;9(10):e1003658. 2013 [PMID: 24130482] (Bioassay, Human)	Bioassay	Human
Todd J, Simpson P, Estis J, Torres V, Wub A Reference range and short- and long-term biological variation of interleukin (IL)-6, IL-17A and tissue necrosis factor-alpha using high sensitivity assays. Cytokine, 2013;64(3):660-5. 2013 [PMID: 24128872] (ELISA (Standard), Human)	ELISA (Standard)	Human
Lee K, Jeong J, Yoo C Long-term incubation with proteasome inhibitors (PIs) induces IkappaBalpha degradation via the lysosomal pathway in an IkappaB kinase (IKK)-dependent and IKK-independent manner. J Biol Chem, 2013;288(45):32777-86. 2013 [PMID: 24085292] (Bioassay, Human)	Bioassay	Human
Zheng Y, McFarland B, Drygin D, Yu H, Bellis S, Kim H, Bredel M, Benveniste E Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma. Clin Cancer Res, 2013;19(23):6484-94. 2013 [PMID: 24036851] (Cell Culture, Human)	Cell Culture	Human
Tsubota Y, Frey J, Raines E Novel ex vivo culture method for human monocytes uses shear flow to prevent total loss of transendothelial diapedesis function. J Leukoc Biol, 2014;95(1):191-5. 2014 [PMID: 24006509] (Bioassay, Human)	Bioassay	Human
Karki R, Kim S, Kim D Magnolol inhibits migration of vascular smooth muscle cells via cytoskeletal remodeling pathway to attenuate neointima formation. Exp Cell Res, 2013;319(20):3238-50. 2013 [PMID: 23906924] (Bioassay, Human)	Bioassay	Human
Rapicavoli N, Qu K, Zhang J, Mikhail M, Laberge R, Chang H A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics. Elife, 2013;2(0):e00762. 2013 [PMID: 23898399] (Bioassay, Mouse)	Bioassay	Mouse
Cai , Minchao, Wu , Jing, Mao , Chaoming, Ren , Jianmin, Li , Pu, Li , Xiao, Zhong , Jiuchang, Xu , Chundi, Zhou , Tong A Lectin-EGF antibody promotes regulatory T cells and attenuates nephrotoxic nephritis via DC-SIGN on dendritic cells. J Transl Med, 2013;11(0):103. 2013 [PMID: 23627732] (Bioassay, Human)	Bioassay	Human
Henig N, Avidan N, Mandel I, Staun-Ram E, Ginzburg E, Paperna T, Pinter R, Miller A Interferon-beta induces distinct gene expression response patterns in human monocytes versus T cells. PLoS ONE, 2013;8(4):e62366. 2013 [PMID: 23626809] (Bioassay, Human)	Bioassay	Human
Liu L, Wang G, Hendricks K, Lee K, Bohnlein E, Junker U, Mosca J Comparison of drug and cell-based delivery: engineered adult mesenchymal stem cells expressing soluble tumor necrosis factor receptor II prevent arthritis in mouse and rat animal models. Stem Cells Transl Med, 2013;2(5):362-75. 2013 [PMID: 23592838] (Bioassay, Human)	Bioassay	Human
Melo , Rossana, Paganoti , Guillher, Dvorak , Ann M, Weller , Peter F The internal architecture of leukocyte lipid body organelles captured by three-dimensional electron microscopy tomography. PLoS ONE, 2013;8(3):e59578. 2013 [PMID: 23555714] (Bioassay, Human)	Bioassay	Human
Awuah P, Nejak-Bowen K, Monga S Role and regulation of PDGFRalpha signaling in liver development and regeneration. Am J Pathol, 2013;182(5):1648-58. 2013 [PMID: 23529017] (Bioassay, Human)	Bioassay	Human
Mabalirajan U, Rehman R, Ahmad T, Kumar S, Leishangthem G, Singh S, Dinda A, Biswal S, Agrawal A, Ghosh B 12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma. Sci Rep, 2013;3(0):1540. 2013 [PMID: 23528921] (Bioassay, Human)	Bioassay	Human
Kim J, Yoon Y, Lee J, Choi E, Yi N, Park K, Park J, Lotvall J, Kim Y, Gho Y Outer membrane vesicles derived from Escherichia coli up-regulate expression of endothelial cell adhesion molecules in vitro and in vivo. PLoS ONE, 2013;8(3):e59276. 2013 [PMID: 23516621] (Bioassay, Human)	Bioassay	Human
Jayaraman P, Sada-Ovalle I, Nishimura T, Anderson A, Kuchroo V, Remold H, Behar S IL-1beta promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation. J Immunol, 2013;190(8):4196-204. 2013 [PMID: 23487424] (Bioassay, Human)	Bioassay	Human
Hanjaya-Putra D, Shen Y, Wilson A, Fox-Talbot K, Khetan S, Burdick J, Steenbergen C, Gerecht S Integration and regression of implanted engineered human vascular networks during deep wound healing. Stem Cells Transl Med, 2013;2(4):297-306. 2013 [PMID: 23486832] (Bioassay, Human)	Bioassay	Human
Peng W, Maintz L, Allam J, Novak N Attenuated TGF-beta1 responsiveness of dendritic cells and their precursors in atopic dermatitis. Eur J Immunol, 2013;43(5):1374-82. 2013 [PMID: 23436698] (Bioassay, Human)	Bioassay	Human
Koeth R, Kalantar-Zadeh K, Wang Z, Fu X, Tang W, Hazen S Protein carbamylation predicts mortality in ESRD. , 2013;0(0):. 2013 [PMID: 23431074] (ELISA (Standard), Human)	ELISA (Standard)	Human
Mohanram V, Skold A, Bachle S, Pathak S, Spetz A IFN-alpha induces APOBEC3G, F, and A in immature dendritic cells and limits HIV-1 spread to CD4+ T cells. J Immunol, 2013;190(7):3346-53. 2013 [PMID: 23427247] (Bioassay, Human)	Bioassay	Human
Manes , Thomas D, Pober , Jordan S TCR-driven transendothelial migration of human effector memory CD4 T cells involves Vav, Rac, and myosin IIA. J Immunol, 2013;190(7):3079-88. 2013 [PMID: 23420881] (Bioassay, Human)	Bioassay	Human
Johnston A, Fritz Y, Dawes S, Diaconu D, Al-Attar P, Guzman A, Chen C, Fu W, Gudjonsson J, McCormick T, Ward N Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation. J Immunol, 2013;190(5):2252-62. 2013 [PMID: 23359500] (Bioassay, Human)	Bioassay	Human
Trenkmann M, Brock M, Gay R, Michel B, Gay S, Huber L Tumor necrosis factor alpha-induced microRNA-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-kappaB signaling. Arthritis Rheum, 2013;65(4):916-27. 2013 [PMID: 23280137] (Bioassay, Human)	Bioassay	Human
Mogami H, Kishore A, Shi H, Keller P, Akgul Y, Word R Fetal fibronectin signaling induces matrix metalloproteases and cyclooxygenase-2 (COX-2) in amnion cells and preterm birth in mice. J Biol Chem, 2013;288(3):1953-66. 2013 [PMID: 23184961] (Cell Culture, Human)	Cell Culture	Human
Brusic , Ana, Hainz , Ursula, Wadleigh , Martha, Neuberg , Donna, Su , Mei, Canning , Christin, Deangelo , Daniel J, Stone , Richard, Lee , Jeng-Shi, Mulligan , Richard, Ritz , Jerome, Dranoff , Glenn, Sasada , Tetsuro, Wu , Catherin Detecting T-cell reactivity to whole cell vaccines: Proof of concept analysis of T-cell response to K562 cell antigens in CML patients. Oncoimmunology, 2012;1(7):1095-1103. 2012 [PMID: 23170257] (Bioassay, Human)	Bioassay	Human
You C, Shi M, Liu Y, Cao M, Luo R, Hermonat P AAV2/IL-12 gene delivery into dendritic cells (DC) enhances CTL stimulation above other IL-12 applications: Evidence for IL-12 intracrine activity in DC. Oncoimmunology, 2012;1(6):847-855. 2012 [PMID: 23162752] (Bioassay, Human)	Bioassay	Human
Sheng Y, Triyana S, Wang R, Das I, Gerloff K, Florin T, Sutton P, McGuckin M MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli. Mucosal Immunol, 2013;6(3):557-68. 2013 [PMID: 23149663] (Bioassay, Human)	Bioassay	Human
Boisson B, Laplantine E, Prando C, Giliani S, Israelsson E, Xu Z, Abhyankar A, Israel L, Trevejo-Nunez G, Bogunovic D, Cepika A, MacDuff D, Chrabieh M, Hubeau M, Bajolle F, Debre M, Mazzolari E, Vairo D, Agou F, Virgin H, Bossuyt X, Rambaud C, Facchetti F, Bonnet D, Quartier P, Fournet J, Pascual V, Chaussabel D, Notarangelo L, Puel A, Israel A, Casanova J, Picard C Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency. Nat Immunol, 2012;13(12):1178-86. 2012 [PMID: 23104095] (Bioassay, Human)	Bioassay	Human
Hutter , Caroline, Kauer , Max, Simonitsch-Klupp , Ingrid, Jug , Gunhild, Schwentner , Raphaela, Leitner , Judith, Bock , Peter, Steinberger , Peter, Bauer , Wolfgang, Carlesso , Nadia, Minkov , Milen, Gadner , Helmut, Stingl , Georg, Kovar , Heinrich, Kriehuber , Ernst Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells. Blood, 2012;120(26):5199-208. 2012 [PMID: 23074278] (Bioassay, Human)	Bioassay	Human
Rossi E, Sanz-Rodriguez F, Eleno N, Duwell A, Blanco F, Langa C, Botella L, Cabanas C, Lopez-Novoa J, Bernabeu C Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration. Blood, 2013;121(2):403-15. 2013 [PMID: 23074273]
Kothari H, Rao L, Vankayalapati R, Pendurthi U Mycobacterium tuberculosis infection and tissue factor expression in macrophages. PLoS ONE, 2012;7(9):e45700. 2012 [PMID: 23029190] (Bioassay, Human)	Bioassay	Human
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