Angiopoietin-1 Products

Description

Angiopoeitin-1 (Ang-1) and Antiopoietin-2 (Ang2) are important for development of the endothelium, by regulating tyrosine phosphorylation of the membrane receptor Tie-2/Tek. Ang-1 binding to Tie-2/Tek causes phosphorylation of the receptor. Ang-2 competes for this binding, and thus blocks receptor phosphorylation. Ang-1 has potential fibrinogen-like domain at the carboxy terminus and coiled-coil regions in the amino terminus. Ang-1 is prominently expressed in the myocardium of atrium and ventricle, mesenchymal and smooth muscle cells surrounding most blood vessels, and lung. In the adult, ANG-1 is also expressed in the heart and liver.To our knowledge, this is the first time that an Ang antibody recognises a band above 55 kD. This antibody gives a band at 75 kD which resembles the original size, because these are soluble highly glycosylated proteins, which should run higher than the calculated molecular weight of 55 kD.

Bioinformatics

Entrez	11600 Mouse 284 Human 89807 Rat
Uniprot	NM_001146 Human NP_001137 Human NP_001137.2 Human Q15389 Human
Product By Gene ID	284
Alternate Names	AGP1 AGPT ANG1 Ang1 ANG-1 angiopoietin 1 angiopoietin-1 KIAA0003

Research Areas for Angiopoietin-1

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer