LC3B Antibody - BSA Free

Knockout Validated: LC3B Antibody [NB100-2220] - Lysates of HeLa parental cell line and LC3B knockout HeLa cell line (KO) untreated (-) or treated (+) with 50 uM CQ for 18 hours. PVDF (Polyvinylidene difluoride) membrane was probed with 0.5 ug/mL of Rabbit Anti-LC3B Polyclonal Antibody (Catalog # NB100-2220) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog# HAF008). A specific band was detected for LC3B at a molecular weight of approximately 15 kDa (as indicated) in the parental HeLa cell line, but is not detectable in the knockout HeLa cell line. GAPDH is shown as a loading control. This experiment was conducted under reducing conditions.

Knockout Validated: LC3B Antibody [NB100-2220] - LC3B was detected in immersion fixed CQ treated HeLa cells (left) but was not detected in LC3B knockout HeLa cells (right) using rabbit anti-human LC3B polyclonal antibody (Catalog #NB100-2220) at 0.3 ug/mL for 3 hours at room temperature. Cells were stained using the NorthernLights(TM) 557-conjugated anti-Rabbit IgG Secondary Antibody (red; Catalog # NL004) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm.

Western Blot: LC3B Antibody [NB100-2220] - Contribution of autophagy to lipid droplet formation in WT and KO NSC34 cells.(A) WT and KO NSC 34 cells were treated with (+) or without (-) bafilomycin A (bafA) under basal or HBSS starvation conditions for 4 h and blotted for p62, LC3, and GAPDH. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/32321733) licensed under a CC-BY licence.

Immunohistochemistry: LC3B Antibody [NB100-2220] - TMEM16A inhibited AngII-induced autophagy in aortas. (D) Representative immunofluorescence staining of LC3 (green) and a-SMA (red) in aortas. Scale bars, 20 um. Quantification of LC3B puncta. Five random fields (2,500 um2/filed) were measured in one section. **P < 0.01 vs. sham + TMcon; ##P < 0.01 vs. AngII + TMcon, one-way ANOVA. n = 14 sections from seven mice per group. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/32226533) licensed under a CC-BY licence.

Immunohistochemistry-Frozen: LC3B Antibody [NB100-2220] - LC3 accumulation in muscle fibers from patients with PAD (row B - E). Normal fibers from a Non-PAD sample (row A). Scale bar = 100 uM. Image from verified customer review.

Immunohistochemistry: LC3B Antibody [NB100-2220] - Localization of LC3 by immunohistochemical method. The immunohistochemical staining shows that LC3, CRF, and HIF-1alpha have an overlapping localization in villous and extravillous trophoblast. d: decidua; v: villi; DeVe: decidual vessel. Original magnification 40x. Image collected and cropped by CiteAb from the following publication (//www.hindawi.com/journals/bmri/2013/689768/) licensed under a CC-BY licence.

Western Blot: LC3B Antibody [NB100-2220] - Detection of LC3B in mouse ES cell lysates using Rabbit anti- [Catalog # NB100-2220]. LC3 detected at a molecular weight of approximately 17 kDa. Atg5-/- ES cells from Dr. Noboru Mizushima [Mizushima, N. et al. J. Cell Biol. 152 (2001)] Photo courtesy of Dr. Beth Levine, UT SW Medical Center.

Immunocytochemistry/Immunofluorescence: LC3B Antibody [NB100-2220] - ORP1L and VAP-A form cholesterol-dependent ER-AV contact sites MelJuSo cells expressing GFP or GFP-tagged ORP1L mutants were fixed and stained for LC3 and Calnexin. Y477 and D478 in the FFAT motif were mutated to alanines in the ORP1L ydaa mutant. Scale bar, 10 um. Right: co-immunoprecipitation for ORP1L (mutants) with VAP-A. GFP-ORP1L mutants or GFP were isolated from lysates of HEK293T cells co-overexpressing HA-VAPA using GFP-Trap beads. Western blot filters were probed for isolated GFP-tagged proteins, the associated HA-VAP-A and the input HA-VAP-A, as indicated. Image collected and cropped by CiteAb from the following publication (//www.nature.com/doifinder/10.1038/ncomms11808), licensed under a CC-BY licence.

Western Blot: LC3B Antibody [NB100-2220] - Lysates of mouse NIH3T3 and rat PC-12 cell lines untreated (-) or treated (+) with CQ. PVDF (Polyvinylidene difluoride) membrane was probed with 0.5 ug/mL rabbit anti-LC3B polyclonal Antibody (Catalog # NB100-2220, Novus Biologicals), followed by 1:2000 dilution of goat anti-rabbit IgG secondary antibody. LC3 detected at a molecular weight of approximately 15 kDa in treated NIH3T3 and PC-12 cells.

Western Blot: LC3B Antibody [NB100-2220] - Detection of LC3I and LC3II in mouse cochlea cell line SV-K1 using Rabbit anti- [Catalog # NB100-2220]. Cells were treated with CQ (1 uM), and As2O3 (1 uM) for 24 hrs. Image from verified customer review.

Western Blot: LC3B Antibody [NB100-2220] - Autophagy Investigation. (A) Representative WBs (Western Blots) of LC3B-I, LC3B-II and GAPDH loading control in DANs derived from 4 iPD patients and 4 healthy controls. (B) WBs from three independent experiments were quantified by densitometry and LC3B-II normalized to a loading control. Grouping of data by healthy vs iPD as well as iPD stratified for T/T and C/C genotype. (C) Ratio of LC3B-II (normalized to loading control) following bafilomycin treatment/untreated. Citation: Marrone L, Bus C, Schondorf D, Fitzgerald JC, Kubler M, Schmid B, et al. (2018) Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease. PLoS ONE 13(3): e0192497. //doi.org/10.1371/journal.pone.0192497

Western Blot: LC3B Antibody [NB100-2220] - Expression of autophagic protein LC3 in BME-UV1 cells forming acinar structures on Matrigel. Representative images of Western blot analysis of LC3 in bovine MECs grown in 3D culture for 3, 6, 9, and 14 days in differentiation medium (control), enriched with 17beta-estradiol (E2, 1 nM), progesterone (P4, 5 ng/mL), or both (E + P); expression of beta-actin was used as a loading control; graphs below the images show the results of densitometric analysis, in which IOD of each band was measured, and the values were normalized to IOD of beta-actin; the IOD results are presented as means +/- SEM from at least three separate experiments. Image collected and cropped by CiteAb from the following publication (//www.hindawi.com/journals/bmri/2014/382653/) licensed under a CC-BY licence.

Western Blot: LC3B Antibody [NB100-2220] - GNA triggers the formation of autophagic markers in A549 and HeLa cell. Effects of GNA on LC3 protein. A549 cells were treated with various concentrations of GNA for 24 hours or 3 uM GNA for the indicated periods of time, then analyzed by western blotting using anti-LC3 antibodies. GAPDH protein was used as the loading control. The bar graph shows the band intensities of LC3-II relative to those of GAPDH. Mean+/- SEM, n = 3, *means p<0.05, ** p<0.01, one-way ANOVA. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0083604), licensed under a CC-BY licence.

Immunocytochemistry/Immunofluorescence: LC3B Antibody [NB100-2220] - Autophagosomes accumulate in neurons of the VH gray matter at day 1 after SCI. Representative images of IHC staining for LC3 (green) and neuronal marker NeuN (red) in VH of gray matter from sham and SCI animals. Stronger co-localization between NeuN and LC3 is apparent at day 1 after SCI. Scale bar is 20 um. Image collected and cropped by CiteAb from the following publication (//www.nature.com/articles/cddis2014527) licensed under a CC-BY licence.

Immunocytochemistry/Immunofluorescence: LC3B Antibody [NB100-2220] - Autophagosomes accumulate in microglia and oligodendrocytes of the dorsal white matter adjacent to injury after SCI. Representative images of IHC staining for LC3 (green) and activated microglia marker CD11B (red) in dorsal white matter of sham and SCI animals. Increased co-localization between LC3 and CD11B is apparent at day 1 after SCI. Image collected and cropped by CiteAb from the following publication (//www.nature.com/articles/cddis2014527) licensed under a CC-BY licence.

Immunohistochemistry: LC3B Antibody [NB100-2220] - Staining of rat brain tissue section. Analysis using Rabbit anti-LC3B Antibody [Catalog # NB100-2220]. Image from verified customer review.

Immunohistochemistry-Paraffin: LC3B Antibody [NB100-2220] - Human ovarian Cancer tissue stained using heat mediated antigen retrieval in pH 6.0 citrate buffer at 1:200 dilution. Image provided by verified customer review.

Immunohistochemistry-Paraffin: LC3B Antibody [NB100-2220] - FFPE (Formalin-Fixed Paraffin-Embedded) tissue section of mouse brain using 1:200 dilution of Rabbit anti-LC3B antibody [Catalog # NB100-2220]. The specific signal of LC3 was detected using HRP-conjugated secondary antibody with DAB (3, 3 -diaminobenzidine) reagent, and nuclei of cells were counterstained using hematoxylin. This LC3B antibody generated a low to moderate levels of cytoplasmic staining in the glial cells. The neurons depicted a moderate to strong staining for LC3 in their cytoplasm.

Immunohistochemistry: LC3B Antibody [NB100-2220] - Analysis using the Biotin conjugate of Rabbit anti-LC3B Antibody [Catalog # NB100-2220]. Staining of brain, cerebral cortex, neurons with cell processes.

Immunohistochemistry: LC3B Antibody [NB100-2220] - SCI leads to lysosomal dysfunction. Representative high magnification images ( x 60) of LC3 (green) and CTSD (red) staining in VH of gray matter from sham and day 1 SCI animals. Decrease in number and intensity of CTSD puncta (lysosomes) and increase in LC3 puncta (autophagosomes) is apparent after SCI. Scale bar is 10 um. Image collected and cropped by CiteAb from the following publication (//www.nature.com/articles/cddis2014527) licensed under a CC-BY licence.

Simple Western: LC3B Antibody [NB100-2220] - Image shows a specific band for LC3B at a molecular weight of approximately 15 kDa in 0.5 mg/mL of Neuro2A lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.

• Reactivity: Hu, Mu, Rt, Po, Al, Av, Ba, Bv, Ca, Ch, ChHa, Gp, Ha, In, Pm, Pm, Rb, SyHa, Ze
• Applications: WB, Simple Western, ELISA, Flow, IB, ICC/IF, IHC, IHC-Fr, IHC-P, IP, PAGE, PLA, ChIP, KD, KO
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

LC3B Antibody - BSA Free Summary

• Immunogen: Polyclonal LC3B Antibody was made to a synthetic peptide made to an N-terminal portion of the human LC3B protein sequence (between residues 1-100). [UniProt# Q9GZQ8]
• Localization: Type I form of LC3B is cytoplasmic, whereas the type II form of LC3B binds to the autophagic membranes.
• Marker: Autophagosome Marker
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MAP1LC3B
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Chromatin Immunoprecipitation (ChIP)
  • ELISA
  • Flow Cytometry
  • Immunoblotting
  • Immunocytochemistry/Immunofluorescence 1:200
  • Immunohistochemistry 1:200 - 1:400
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin 1:200 - 1:400
  • Immunoprecipitation 20 ug/500 ug of protein
  • Knockdown Validated
  • Knockout Validated
  • Proximity Ligation Assay
  • SDS-Page
  • Simple Western 1:50
  • Western Blot 0.5 - 2.0 ug/mL
• Application Notes: Use in SDS-PAGE reported in scientific literature (PMID:34315875).
• Theoretical MW: 14.688 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Control:

  Human Brain Cerebral Cortex Whole Tissue Lysate (Adult Whole Normal)
  Human Brain Whole Tissue Lysate (Adult Whole Normal)
  Neuro2a Chloroquine Treated / Untreated Cell Lysate
  HeLa Chloroquine Treated / Untreated Cell Lysate

• Control Peptide:

  LC3B Protein (NB100-2220PEP)

Reactivity Notes

Use in Rat reported in scientific literature (PMID:34622072). Use in Chinese Hamster reported in scientific literature (PMID:34332287). Mouse reactivity reported in scientific literature (PMID:32814898). Bovine reactivity reported in scientific literature (PMID: 24895572). Primate reactivity reported in scientific literature (PMID: 25142602). Canine reactivity reported in scientific literature (PMID: 25839646). Avian reactivity reported in scientific literature (PMID: 29546310). Hamster reactivity reported in scientific literature (PMID: 26423766). Rabbit reactivity reported in scientific literature (PMID: 26497211). The mouse detection has been reported to be weaker than the human. Immunogen displays the following percentage of sequence identity for non-tested species: Xenopus 84%. Invertebrate reactivity reported in scientific literature (PMID: 26716072 ). Monkey reactivity reported in scientific literature (PMID: 30324853). Guinea pig reactivity reported from a verified customer review. Rat reactivity reported in scientific literature (PMID: 30744518). Bacteria reactivity reported in scientific literature (PMID: 28783414). Chicken reactivity reported in scientific literature (PMID: 30649814). Porcine reactivity reported in scientific literature (PMID: 30789643). Golden Syrian hamster reactivity reported in scientific literature (PMID: 23180219). Zebrafish reactivity reported in scientific literature (PMID: 29185873). Human reactivity reported in scientific literature (PMID:33086573). Use in Alligator reported in scientific literature (PMID:32061056).

Packaging, Storage & Formulations

• Storage: Store at -20C.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for LC3B Antibody - BSA Free

• anti-LC3B
• Apg8b
• atg8f antibody
• ATG8F
• Autophagy-related protein LC3 B
• Autophagy-related ubiquitin-like modifier LC3 B
• lc3b autophagy marker
• LC3B ihc
• LC3B immunohistochemistry
• LC3B immunoprecipitation
• LC3B western blot
• LC3B
• lc3-i, ii
• LC3II
• MAP1 light chain 3-like protein 2
• MAP1A/1BLC3
• MAP1A/MAP1B LC3 B
• MAP1LC3B
• MAP1LC3B-a
• microtubule associated protein 1 light chain 3 beta
• microtubule associated protein 3 b
• microtubule associated protein 3 beta
• microtubule-associated proteins 1A/1B light chain 3
• microtubule-associated proteins 1A/1B light chain 3B

Background

Autophagy (macroautophagy) is a catabolic process which targets intracellular components such as proteins and organelles for degradation. Originally described as a bulk degradation process, current research supports its selective nature (1). Selective autophagy targets specific cellular components for degradation including the endoplasmic reticulum (2) (ER-phagy), mitochondria (3) (mitophagy), peroxisomes (3) (pexophagy), ribosomes (4) (ribophagy) and bacteria (5) (xenophagy). Autophagy relies on a newly formed phagophore, a membrane structure which elongates, sequesters cellular content, and fuses to form a double membrane vesicle known as the autophagosome. Fusion of autophagosomes with lysosomes gives rise to the autophagolysosome, where cellular components are degraded by lysosome hydrolases (1).

Autophagic flux is supported by autophagy-related proteins (Atgs) initially identified in yeast (6,7). The core autophagy machinery is comprised of 17 Atg proteins that play specific roles in autophagosome formation. Among these Atg proteins, Atg8 is not only involved in autophagosome formation but also functions in cargo selection. In mammals, several Atg8 homologues have been identified including microtubule-associated protein 1 light chain 3 alpha, beta and gamma - LC3A, LC3B, and LC3C (8) respectively, as well as GABA type A receptor-associated protein (GABARAP), GABARAP-Like1, and GABARAP-Like2 (9). LC3 (predicted molecular weight 14kD) is ubiquitously expressed and undergoes posttranslational processing after synthesis. First, the cysteine protease Atg4 cleaves a carboxy terminal sequence to generate the cytosolic form LC3-I. Next, E1-like (Atg7) and E2-like (Atg3) enzymes conjugate phosphatidylethanolamine to the newly exposed carboxyterminal glycine, generating LC3-II. Finally, the Atg12-Atg5-Atg16L1 complex participates in LC3 lipidation and autophagosome formation (10). LC3B-I to LC3B-II conversion correlates with autophagosome number and is considered the best marker to monitor autophagy.

References

1. Yu, L., Chen, Y., & Tooze, S. A. (2018). Autophagy pathway: Cellular and molecular mechanisms. Autophagy. https://doi.org/10.1080/15548627.2017.1378838

2. Forrester, A., De Leonibus, C., Grumati, P., Fasana, E., Piemontese, M., Staiano, L., ... Settembre, C. (2019). A selective ER -phagy exerts procollagen quality control via a Calnexin- FAM 134B complex. The EMBO Journal. https://doi.org/10.15252/embj.201899847

3. He, X., Zhu, Y., Zhang, Y., Geng, Y., Gong, J., Geng, J., ... Zhong, H. (2019). RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation. The EMBO Journal. https://doi.org/10.15252/embj.2018100978

4. Mathai, B., Meijer, A., & Simonsen, A. (2017). Studying Autophagy in Zebrafish. Cells. https://doi.org/10.3390/cells6030021

5. Losier, T. T., Akuma, M., McKee-Muir, O. C., LeBlond, N. D., Suk, Y., Alsaadi, R. M., ... Russell, R. C. (2019). AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles. Cell Reports. https://doi.org/10.1016/j.celrep.2019.01.062

6. Nakatogawa, H., Suzuki, K., Kamada, Y., & Ohsumi, Y. (2009). Dynamics and diversity in autophagy mechanisms: Lessons from yeast. Nature Reviews Molecular Cell Biology. https://doi.org/10.1038/nrm2708

7. Tsukada, M., & Ohsumi, Y. (1993). Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Letters. https://doi.org/10.1016/0014-5793(93)80398-E

8. Wild, P., McEwan, D. G., & Dikic, I. (2014). The LC3 interactome at a glance. Journal of Cell Science. https://doi.org/10.1242/jcs.140426

9. Igloi, G. L. (2001). Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABAA receptor-associated protein. Genomics. https://doi.org/10.1006/geno.2001.6555

10. Glick, D., Barth, S., & Macleod, K. F. (2010). Autophagy: Cellular and molecular mechanisms. Journal of Pathology. https://doi.org/10.1002/path.2697

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for LC3B Antibody (NB100-2220)(1414)

Publications using NB100-2220	Applications	Species
McBrearty N, Cho C, Chen J et al. Tumor suppressive and immune-stimulating roles of cholesterol 25-hydroxylase in pancreatic cancer cells Molecular cancer research : MCR 2022-11-15 [PMID: 36378658]
Imam KMSU, Tian Y, Xin F et al. Lactucin, a Bitter Sesquiterpene from Cichorium intybus, Inhibits Cancer Cell Proliferation by Downregulating the MAPK and Central Carbon Metabolism Pathway Molecules (Basel, Switzerland) 2022-10-29 [PMID: 36364182] (WB, Human)	WB	Human
Kim HJ, Lee PCW, Hong JH Lamin-A/C Is Modulated by the Involvement of Histamine-Mediated Calcium/Calmodulin-Dependent Kinase II in Lung Cancer Cells International journal of molecular sciences 2022-08-13 [PMID: 36012358] (WB, Human)	WB	Human
Singh AK, Praharaj M, Lombardo KA, Yoshida T Recombinant BCG overexpressing a STING agonist elicits trained immunity and improved antitumor efficacy in non-muscle invasive bladder bioRxiv 2020-01-01 (ICC/IF, Human)	ICC/IF	Human
Calis S, Dogan B, Durdagi S et al. A novel BH3 mimetic Bcl-2 inhibitor promotes autophagic cell death and reduces in vivo Glioblastoma tumor growth Cell death discovery 2022-10-29 [PMID: 36309485] (ICC/IF, Human)	ICC/IF	Human
Dong J, Guo C, Yang Z et al. Follicle-Stimulating Hormone Alleviates Ovarian Aging by Modulating Mitophagy- and Glycophagy-Based Energy Metabolism in Hens Cells 2022-10-18 [PMID: 36291137] (IHC-P, Chicken)	IHC-P	Chicken
Kim YS, Ko B, Kim DJ et al. Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D Nature communications 2022-10-14 [PMID: 36241614]
Schmitt D, Bozkurt S, Henning-Domres P et al. Lipid and protein content profiling of isolated native autophagic vesicles EMBO reports 2022-10-10 [PMID: 36215690] (FLOW, ICC/IF)	FLOW, ICC/IF
Hekman KE, Koss KM, Ivancic DZ et al. Autophagy Enhances Longevity of Induced Pluripotent Stem Cell-Derived Endothelium via mTOR-Independent ULK1 Kinase Stem cells translational medicine 2022-09-29 [PMID: 36173887] (WB, Human)	WB	Human
Ying Z, Lv Q, Yao X et al. BAG3 promotes autophagy and suppresses NLRP3 inflammasome activation in Parkinson’s disease Annals of Translational Medicine 2022-11-01 [PMID: 36544667] (WB, Mouse)	WB	Mouse
Qiu-Jiao Z, Jian W, Ying Li et al PRKCA Promotes Mitophagy through the miR-15a-5p/PDK4 Axis to Relieve Sepsis-Induced Acute Lung Injury Infection and immunity 2022-11-30 [PMID: 36448837]
Hung CH, Hsu HY, Chiou HC et al. Arsenic Induces M2 Macrophage Polarization and Shifts M1/M2 Cytokine Production via Mitophagy International journal of molecular sciences 2022-11-10 [PMID: 36430358] (ICC/IF, Human)	ICC/IF	Human
Lyu P, Jiang H RNA-Sequencing Reveals Upregulation and a Beneficial Role of Autophagy in Myoblast Differentiation and Fusion Cells 2022-11-10 [PMID: 36428978] (WB, Mouse) Details: Dilution used for WB 1:1000	WB	Mouse
Kataura T, Sedlackova L, Otten EG et al. Autophagy promotes cell survival by maintaining NAD levels Developmental cell 2022-11-21 [PMID: 36413951]
Choi SW, Oh H, Park SY et al. Netrin-1 attenuates hepatic steatosis via UNC5b/PPAR gamma -mediated suppression of inflammation and ER stress Life sciences 2022-12-15 [PMID: 36400204] (WB, Mouse) Details: Dilution used in WB 1:1000	WB	Mouse
Sun S, Hou H, Ma G et al. The interaction between E3 ubiquitin ligase Parkin and mitophagy receptor PHB2 links inner mitochondrial membrane ubiquitination to efficient mitophagy The Journal of biological chemistry 2022-11-12 [PMID: 36379251] (WB, Human)	WB	Human
Carotenuto P, Romano A, Barbato A et al. Targeting the MITF/APAF-1 axis as salvage therapy for MAPK inhibitors in resistant melanoma Cell reports 2022-11-08 [PMID: 36351409] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Moore TM, Cheng L, Wolf DM et al. Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes Nature communications 2022-11-04 [PMID: 36333379] (WB, Mouse)	WB	Mouse
Wang YC, Tsai MC, Chen YS et al. NPRL2 down-regulation facilitates the growth of hepatocellular carcinoma via the mTOR pathway and autophagy suppression Hepatology communications 2022-12-01 [PMID: 36321403] (IHC-P, WB, Human)	IHC-P, WB	Human
Sun Y, Guan X, Zhang T et al. Regulation of the sensitivity of hepatocarcinoma cells by ORMDL3, to sorafenib by autophagy Medical oncology (Northwood, London, England) 2022-08-16 [PMID: 35972600] (IHC-P, Mouse)	IHC-P	Mouse
Yu J, Liu T, Gao Z et al. Akkermansia muciniphila Colonization Alleviating High Fructose and Restraint Stress-Induced Jejunal Mucosal Barrier Disruption Nutrients 2022-07-30 [PMID: 35956340] (WB, Mouse) Details: Dilution used 1:1000, jejunum samples from female C57BL/6J mice	WB	Mouse
Bock J, KUhnle N, Knopf JD et al. Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation Cell reports 2022-08-09 [PMID: 35947953] (WB) Details: Supplementary Figure S5.	WB
RamIrez-Pardo I, Villarejo-Zori B, JimEnez-Loygorri JI et al. Ambra1 haploinsufficiency in CD1 mice results in metabolic alterations and exacerbates age-associated retinal degeneration Autophagy 2022-07-24 [PMID: 35875981] (ICC/IF, Mouse) Details: Dilutions: 1:200	ICC/IF	Mouse
Kissner V ATG14L and ZBTB16: Critical Roles in Aggrephagy in STHdhQ7/Q7 Striatal Neurons Thesis 2020-01-01
Su M, Chen C, Li S Et al. Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis Nat Cardiovasc Res 2022-08-15 [PMID: 35967457] (FLOW, Human) Details: Citation using the Alexa Fluor 405 version of this antibody.	FLOW	Human
Bertola N, Degan P, Cappelli E, Ravera S Mutated FANCA Gene Role in the Modulation of Energy Metabolism and Mitochondrial Dynamics in Head and Neck Squamous Cell Carcinoma Cells 2022-07-30 [PMID: 35954197] (WB, Human) Details: Dilution used 1:1000	WB	Human
Oh H, Cho W, Abd El-Aty A et al. Resolvin D3 Improves the Impairment of Insulin Signaling in Skeletal Muscle and Nonalcoholic Fatty Liver Disease Through AMPK/Autophagy-Associated Attenuation of ER Stress SSRN Electronic Journal 2022-07-10 [PMID: 35948170]
Li Y, Lei Z, Ritzel RM Et al. Impairment of autophagy after spinal cord injury potentiates neuroinflammation and motor function deficit in mice Theranostics 2022-08-01 [PMID: 35910787] (IHC-P, WB, Mouse) Details: Citation using the Alexa Fluor 647 version of this antibody.	IHC-P, WB	Mouse
Baytas O, Kauer J, Morrow E Loss of mitochondrial enzyme GPT2 causes early neurodegeneration in locus coeruleus Neurobiology of Disease 2022-07-01 [PMID: 35908744] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Dong AQ, Yang YP, Jiang SM et al. Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson's disease Acta pharmacologica Sinica 2022-07-27 [PMID: 35896696] (WB, Mouse)	WB	Mouse
Danese A, Patergnani S, Maresca A et al. Pathological mitophagy disrupts mitochondrial homeostasis in Leber's hereditary optic neuropathy Cell reports 2022-07-19 [PMID: 35858578]
yang C, Su C, Iyaswamy A et al. Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer’s disease therapy Acta Pharm Sin B 2022-07-18 [PMID: 35847498]
Peischard S, Moller M, Disse P Et al. Virus-induced inhibition of cardiac pacemaker channel HCN4 triggers bradycardia in human-induced stem cell system Cell Mol Life Sci 2022-07-21 [PMID: 35864219] (ICC, Human) Details: Citation using the Alexa Fluor 350 version of this antibody.	ICC	Human
Walter PB, Hohman LS, Rokeby A et al. The effects of glutamine supplementation on markers of apoptosis and autophagy in sickle cell disease peripheral blood mononuclear cells Complementary therapies in medicine 2022-07-14 [PMID: 35843474] (WB, Human) Details: 1:1000 5% milk in TBST, Fig. 1	WB	Human
Wrobel L, Hill SM, Djajadikerta A et al. Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance Nature communications 2022-07-16 [PMID: 35842429] (WB, Human) Details: Supplementary fig. 3, Dilution 1:1000	WB	Human
Ruz C, Alcantud J, Vives F et al. Seventy-Two-Hour LRRK2 Kinase Activity Inhibition Increases Lysosomal GBA Expression in H4, a Human Neuroglioma Cell Line International Journal of Molecular Sciences 2022-06-22 [PMID: 35805938]
Chaudhary, R;Liu, B;Bensalem, J;Sargeant, T;Page, A;Wittert, G;Hutchison, A;Heilbronn, L; Intermittent fasting activates markers of autophagy in mouse liver, but not muscle from mouse or humans Nutrition [PMID: 35660501]
Yan J, Shen M, Sui B Et al. Autophagic LC3(+) calcified extracellular vesicles initiate cartilage calcification in osteoarthritis Sci Adv 2022-05-11 [PMID: 35544558] Details: Citation using the FITC version of this antibody.
Gund R, Christiano AM Impaired autophagy promotes hair loss in the C3H/HeJ mouse model of alopecia areata Autophagy 2022-06-02 [PMID: 35652954]
Iwasaki M, Kawahara Y, Okubo C et al. Multi-omics approach reveals post-transcriptionally regulated genes are essential for human pluripotent stem cells iScience 2022-04-01 [PMID: 35573189]
Dong Y, Zhu G, Wang S et al. Toosendanin, a novel potent vacuolar-type H+-translocating ATPase inhibitor, sensitizes cancer cells to chemotherapy by blocking protective autophagy International Journal of Biological Sciences 2022-04-08 [PMID: 35541921] (WB, Human)	WB	Human
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Xiang P, Mohamud Y, Luo H SNAP47 Interacts with ATG14 to Promote VP1 Conjugation and CVB3 Propagation Cells 2021-08-20 [PMID: 34440910] (WB, Human)	WB	Human
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Yu Y, Men S, Zhang Y miR-20a-5p ameliorates ovalbumin (OVA)-induced mouse model of allergic asthma through targeting ATG7-regulated cell death, fibrosis and inflammation International immunopharmacology 2021-03-06 [PMID: 33684878] (ICC/IF, WB, Mouse)	ICC/IF, WB	Mouse
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Soto-Avellaneda A Autophagy Regulation by Lipid Factors with Implications for Parkinson's Disease Thesis 2021-11-19 (WB, Human)	WB	Human
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Chen X, Wang Y, Qu N, et al. PLC gamma 1 inhibition-driven autophagy of IL-1 beta -treated chondrocyte confers cartilage protection against osteoarthritis, involving AMPK, Erk and Akt Journal of cellular and molecular medicine 2020-12-28 [PMID: 33372388] (IHC, WB, Human)	IHC, WB	Human
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Zhao Y, Zou Z, Sun D et al. GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex Autophagy 2020-11-23 [PMID: 33222586] (WB)	WB
Raj P, Song R, Zhu H et al. Deep sequencing reveals a DAP1 regulatory haplotype that potentiates autoimmunity in systemic lupus erythematosus Genome Biol 2020-11-19 [PMID: 33213505] (WB, Human)	WB	Human
Deng R, Zhang HL, Huang JH et al. MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis Autophagy 2020-11-19 [PMID: 33213267] (WB, Human) Details: Western blot analysis performed on knockdown and knockout ULK1 HEK293T cell.	WB	Human
Goyala A, Baruah A, Mukhopadhyay A The genetic paradigms of dietary restriction fail to extend life span in cep-1(gk138) mutant of C. elegans p53 due to possible background mutations PLoS One 2020-11-12 [PMID: 33180887]
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Mohamud Y, Shi J, Tang H et al. Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexes Sci Rep 2020-11-04 [PMID: 33149253] (WB)	WB
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Geng X, Wang F, Tian D et al. Cardiac glycosides inhibit cancer through Na/K-ATPase-dependent cell death induction Biochem. Pharmacol. 2020-09-22 [PMID: 32976831] (WB, Human)	WB	Human
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Assar EA, Tumbarello DA Loss of the Essential Autophagy Regulators FIP200 or Atg5 Leads to Distinct Effects on Focal Adhesion Composition and Organization Front Cell Dev Biol 2020-08-04 [PMID: 32850845] (ICC/IF, WB)	ICC/IF, WB
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Sathyanarayan A, Mashek MT, Mashek DG. ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism. Cell Rep. 2017-04-04 [PMID: 28380348] (IB, WB, Mouse)	IB, WB	Mouse
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Zea AH, Stewart T, Ascani J et al. Activation of the IL-2 Receptor in Podocytes: A Potential Mechanism for Podocyte Injury in Idiopathic Nephrotic Syndrome? PLoS One 2016-07-07 [PMID: 27389192] (WB)	WB
Svensson D, Nebel D, Voss U et al. Vitamin D-induced up-regulation of human keratinocyte cathelicidin anti-microbial peptide expression involves retinoid X receptor a Cell Tissue Res. 2016-06-30 [PMID: 27357804] (WB, Human)	WB	Human
Xu YJ, Lin J, Lu Y et al. Lanthanide co-doped paramagnetic spindle-like mesocrystals for imaging and autophagy induction Nanoscale 2016-07-21 [PMID: 27346838]
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Choi MS, Kim HJ, Ham M et al. Amber Light (590 nm) Induces the Breakdown of Lipid Droplets through Autophagy-Related Lysosomal Degradation in Differentiated Adipocytes. Sci Rep 2016-06-27 [PMID: 27346059] (WB)	WB
Wang H, Tian C, Sun J et al. Overexpression of PLK3 Mediates the Degradation of Abnormal Prion Proteins Dependent on Chaperone-Mediated Autophagy Mol. Neurobiol. 2016-06-25 [PMID: 27344333]
Periyasamy P, Guo ML, Buch S. Cocaine induces astrocytosis through ER stress-mediated activation of autophagy. Autophagy 2016-06-23 [PMID: 27337297] (IHC, Mouse)	IHC	Mouse
Davis MA, Delaney JR, Patel CB et al. Nelfinavir is effective against human cervical cancer cells in vivo: a potential treatment modality in resource-limited settings. Drug Des Devel Ther 2016-06-02 [PMID: 27330277] (WB)	WB
Morgan MJ, Thorburn A. Measuring Autophagy in the Context of Cancer. Adv Exp Med Biol 2016-01-01 [PMID: 27325265] (WB)	WB
Choi H, Merceron C, Mangiavini L et al. Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Autophagy 2016-06-17 [PMID: 27314664] (ICC/IF, Mouse)	ICC/IF	Mouse
He L, Weber KJ, Diwan A, Schilling JD. Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism. J Leukoc Biol 2016-11-01 [PMID: 27312848]
Kuramoto K, Wang N, Fan Y et al. Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids. Autophagy. 2016-09-01 [PMID: 27305347]
Zhang D, Wang W, Sun X et al. AMPK regulates autophagy by phosphorylating BECN1 at Threonine 388. Autophagy 2016-06-15 [PMID: 27304906] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Narasimhan PB, Bennuru S, Meng Z et al. Microfilariae of Brugia malayi inhibit the mTOR pathway and induce autophagy in human dendritic cells. Infect. Immun. 2016-06-16 [PMID: 27297394] Details: This publication used the AF647 conjugated form of this antibody (NB100-2220AF647)
Parks A, Marceau F. Lysosomotropic cationic drugs induce cytostatic and cytotoxic effects: Role of liposolubility and autophagic flux and antagonism by cholesterol ablation. Toxicol. Appl. Pharmacol. 2016-06-08 [PMID: 27288732] (FLOW, ICC/IF, WB, Human)	FLOW, ICC/IF, WB	Human
Wijdeven RH, Janssen H, Nahidiazar L et al. Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway. Nat Commun 2016-06-10 [PMID: 27283760] (WB)	WB
Bento CF, Ashkenazi A, Jimenez-Sanchez M, Rubinsztein DC The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway. Nat Commun 2016-06-09 [PMID: 27278822] (WB)	WB
Song EJ, Lee SJ, Lim HS et al. Vibrio vulnificus VvhA induces autophagy-related cell death through the lipid raft-dependent c-Src/NOX signaling pathway Sci Rep. [PMID: 27250250] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Wang Q, Guo W, Hao B et al. Mechanistic study of TRPM2-Ca(2+)-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition. Autophagy 2016-05-31 [PMID: 27245989] (WB, Mouse)	WB	Mouse
Musolino V, Palus S, Tschirner A. Megestrol acetate improves cardiac function in a model of cancer cachexia-induced cardiomyopathy by autophagic modulation. Journal of Cachexia, Sarcopenia and Muscle. 2016-04-07 [PMID: 27239419] (WB, Rat)	WB	Rat
Barnard RA, Regan DP, Hansen RJ et al. Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease. J Pharmacol Exp Ther 2016-08-01 [PMID: 27231155] (WB, Mouse)	WB	Mouse
Mitzelfelt KA, Limphong P, Choi MJ et al. Human 343delT HSPB5 Chaperone associated with Early-onset Skeletal Myopathy causes Defects in Protein Solubility. J. Biol. Chem. 2016-05-19 [PMID: 27226619] (WB, Human)	WB	Human
Goodall ML, Fitzwalter BE, Zahedi S et al. The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis. Dev. Cell. 2016-05-23 [PMID: 27219062] (PLA, WB, Mouse)	PLA, WB	Mouse
Boonhok R, Rachaphaew N, Duangmanee A et al. LAP-like process as an immune mechanism downstream of IFN-gamma in control of the human malaria Plasmodium vivax liver stage. Proc. Natl. Acad. Sci. U.S.A. 2016-05-16 [PMID: 27185909] (ICC/IF, Human) Details: This publication used the AF647 conjugated form of this antibody (NB100-2220AF647)	ICC/IF	Human
Panda PK, Behera B, Meher BR et al. Abrus agglutinin, a type II ribosome inactivating protein inhibits Akt/PH domain to induce endoplasmic reticulum stress mediated autophagy-dependent cell death. Mol. Carcinog. 2016-05-16 [PMID: 27182794] (WB, Human)	WB	Human
Park SE, Yi HJ, Suh N et al. Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-kB. Oncotarget. 2016-06-28 [PMID: 27174920] (WB, Human)	WB	Human
Song JX, Sun YR, Peluso I et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 2016-05-12 [PMID: 27172265] (WB, Mouse)	WB	Mouse
Pastore N, Brady OA, Diab HI et al. TFEB and TFE3 Cooperate in the Regulation of the Innate Immune Response in Activated Macrophages. Autophagy. 2016-05-12 [PMID: 27171064] (WB, Mouse)	WB	Mouse
Avagliano L, Massa V, Zullino S et al. Inflammation modulates LC3 expression in human preterm delivery. J. Matern. Fetal. Neonatal. Med. 2016-05-16 [PMID: 27125211] (ICC/IF, IHC-P, Human)	ICC/IF, IHC-P	Human
Livingston MJ, Ding HF, Huang S et al. Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction. Autophagy. 2016-04-28 [PMID: 27123926] (WB, Mouse)	WB	Mouse
Zhang X, Zhou Y, Xu M, Chen G. Autophagy Is Involved in the Sevoflurane Anesthesia-Induced Cognitive Dysfunction of Aged Rats. PLoS ONE. 2016-04-26 [PMID: 27111854] (WB, Rat)	WB	Rat
Tang Y, Fickert P, Trauner M et al. Autophagy Induced by Exogenous Bile Acids is Therapeutic in a Model of Alpha-1-AT Deficiency Liver Disease. Am. J. Physiol. Gastrointest. Liver Physiol. 2016-04-21 [PMID: 27102560] (WB, Mouse)	WB	Mouse
Duan L, Yi M, Chen J et al. Mycobacterium tuberculosis EIS gene inhibits macrophage autophagy through up-regulation of IL-10 by increasing the acetylation of histone H3. Biochem. Biophys. Res. Commun. 2016-05-13 [PMID: 27079235] (WB, Mouse)	WB	Mouse
He L, Weber KJ, Schilling JD. Glutamine Modulates Macrophage Lipotoxicity. Nutrients. 2016-04-15 [PMID: 27077881] (WB, Mouse)	WB	Mouse
Choudhury KR, Bucha S, Baksi S et al. Chaperone-like protein HYPK and its interacting partners augment autophagy. Eur. J. Cell Biol. 2016-04-01 [PMID: 27067261] (WB, Mouse)	WB	Mouse
Li D, Wang G, Han D et al. MP Resulting in Autophagic Cell Death of Microglia through Zinc Changes against Spinal Cord Injury Biomed Res Int 2016-04-09 [PMID: 27057544]
Zhou YF, Wang QX, Zhou HY, Chen G. Autophagy activation prevents sevoflurane-induced neurotoxicity in H4 human neuroglioma cells. Acta Pharmacol. Sin. 2016-04-04 [PMID: 27041458] (WB, Human)	WB	Human
Wang Z, Du T, Dong X et al. Autophagy inhibition facilitates erlotinib cytotoxicity in lung cancer cells through modulation of endoplasmic reticulum stress. Int. J. Oncol. 2016-04-01 [PMID: 27035631]
Lopes VR, Loitto V, Audinot JN et al. Dose-dependent autophagic effect of titanium dioxide nanoparticles in human HaCaT cells at non-cytotoxic levels. J Nanobiotechnology 2016-03-22 [PMID: 27001369] (WB)	WB
Fritzen AM, Frosig C, Jeppesen J et al. Role of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle Cell. Signal. 2016-03-12 [PMID: 26976209] (WB, Mouse)	WB	Mouse
Wang G, Liu X, Gaertig MA et al. Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis Proc Natl Acad Sci U S A. 2016-03-21 [PMID: 26951659] (WB, Mouse)	WB	Mouse
Cheong JW, Kim Y, Eom JI et al. Enhanced autophagy in cytarabine arabinoside-resistant U937 leukemia cells and its potential as a target for overcoming resistance. Mol Med Rep 2016-04-01 [PMID: 26935591] (WB)	WB
Tanaka Y, Nonaka T, Suzuki G et al. Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation. Hum Mol Genet 2016-04-01 [PMID: 26908597]
Berezhnov AV, Soutar MP, Fedotova EI et al. Intracellular pH Modulates Autophagy and Mitophagy. J Biol Chem 2016-04-15 [PMID: 26893374]
Liu Y, Wang X, Wang J et al. Graphene Oxide Attenuates the Cytotoxicity and Mutagenicity of PCB 52 via Activation of Genuine Autophagy. Environ. Sci. Technol. 2016-02-23 [PMID: 26876502] (ICC/IF, WB)	ICC/IF, WB
Liu Y, Takahashi Y, Desai N et al. Bif-1 deficiency impairs lipid homeostasis and causes obesity accompanied by insulin resistance. Sci Rep 2016-02-09 [PMID: 26857140] (ELISA)	ELISA
Wu X, Fleming A, Ricketts T et al. Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis. Nat Commun. 2016-02-03 [PMID: 26837467] (WB, Human)	WB	Human
Gentry EG, Henderson BW, Arrant AE et al. Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration. J Neurosci 2016-01-27 [PMID: 26818518] (WB)	WB
Button RW, Vincent JH, Strang CJ, Luo S Dual PI-3 kinase/mTOR inhibition impairs autophagy flux and induces cell death independent of apoptosis and necroptosis. Oncotarget 2016-02-02 [PMID: 26814436] (ICC/IF)	ICC/IF
Wei J, Long L, Yang K et al. Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis. Nat Immunol 2016-03-01 [PMID: 26808230]
Urtasun R, Elizalde M, Azkona M et al. Splicing regulator SLU7 preserves survival of hepatocellular carcinoma cells and other solid tumors via oncogenic miR-17-92 cluster expression. Oncogene 2016-09-08 [PMID: 26804174]
Tian T, Sun Y, Wu H et al. Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain. Sci Rep. 2016-01-21 [PMID: 26792101] (WB, Mouse) Details: LC3 antibody was used for WB analysis of lysates from the substantia nigra par compacta /SNpc of the brain from control group (Saline), the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/MPTP-treated PD mice, the acupuncture group stimulated at the acupoint GB34, the sham acupuncture group stimulated at the control point, and the rapamycin treatment group (Figure 3a).	WB	Mouse
Yang L, Licastro D, Cava E et al. Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle. Cell Rep. 2016-01-26 [PMID: 26774472] (WB, Human) Details: LC3B/MAP1LC3B antibody was used for Western Blot analysis of human skeletal muscle tissues from Individuals on Western diet/WD or calorie restriction/CR Diet (Figure 3).	WB	Human
Bourdenx M, Daniel J, Genin E et al. Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases Autophagy. 2016-01-12 [PMID: 26761717] (WB, Human)	WB	Human
Mukherjee R, Chakrabarti O. Ubiquitin mediated regulation of the E3 ligase GP78 by Mahogunin in trans affects mitochondrial homeostasis. J. Cell. Sci. 2016-01-07 [PMID: 26743086] (WB, Human)	WB	Human
Kraft LJ, Manral P, Dowler J et al. Nuclear LC3 associates with slowly diffusing complexes that survey the nucleolus. Traffic. 2016-01-05 [PMID: 26728248] (WB, Human)	WB	Human
Masuda GO, Yashiro M, Kitayama K et al. Clinicopathological Correlations of Autophagy-related Proteins LC3, Beclin 1 and p62 in Gastric Cancer. Anticancer Res. 2016-01-01 [PMID: 26722036] (IHC-P, Human)	IHC-P	Human
Buzgariu W, Al Haddad S, Tomczyk S et al. Multi-functionality and plasticity characterize epithelial cells in Hydra. Tissue Barriers 2015-10-01 [PMID: 26716072]
Yuan R, Geng S, Chen K et al. Low-grade inflammatory polarization of monocytes impairs wound healing J Pathol 2015-12-22 [PMID: 26690561] (ICC/IF, Mouse) Details: This citation used the Alexa Fluor 488 version of this antibody.	ICC/IF	Mouse
Lee E, Lee CG, Yim JH et al. Ramalin-Mediated Apoptosis Is Enhanced by Autophagy Inhibition in Human Breast Cancer Cells. Phytother Res. 2015-12-17 [PMID: 26676298] (WB, Human) Details: LC3B antibody was used for WB analysis of lysates from human breast cancer MCF-7 cells and MDA-MB-231 cells which were treated or not with Ramalin, a chemical compound from the Antarctic lichen Ramalina terebrata which is known to exhibit antioxidant and antiinflammatory activities.	WB	Human
Avagliano L, Doi P, Tosi D et al. Cell death and cell proliferation in human spina bifida. Birth Defects Res. Part A Clin. Mol. Teratol. 2015-12-10 [PMID: 26663582] (IHC-P, Mouse)	IHC-P	Mouse
Stotland A, Gottlieb RA. alpha-MHC MitoTimer mouse: In vivo mitochondrial turnover model reveals remarkable mitochondrial heterogeneity in the heart. J. Mol. Cell. Cardiol. 2015-12-02 [PMID: 26654779] (ICC/IF, Mouse)	ICC/IF	Mouse
Fritzen AM, Madsen AB, Kleinert M et al. Regulation of autophagy in human skeletal muscle - Effects of exercise, exercise training and insulin stimulation. J. Physiol. (Lond.). 2015-11-28 [PMID: 26614120] (WB, Human)	WB	Human
Zhang J, Zhou W, Lin J et al. Autophagic lysosomal reformation depends on mTOR reactivation in H2O2-induced autophagy. Int. J. Biochem. Cell Biol. 2015-11-14 [PMID: 26589722] (ICC/IF, Human)	ICC/IF	Human
Park YS, Park JH, Ko J et al. mTOR inhibition by rapamycin protects against deltamethrin-induced apoptosis in PC12 Cells. Environ. Toxicol. 2015-11-21 [PMID: 26588882] (ICC/IF, WB, Rat)	ICC/IF, WB	Rat
Chandra P, Ghanwat S, Matta SK et al. Mycobacterium tuberculosis Inhibits RAB7 Recruitment to Selectively Modulate Autophagy Flux in Macrophages. Sci Rep. 2015-11-06 [PMID: 26541268] (ICC/IF, Human)	ICC/IF	Human
Majumder P, Chakrabarti O. Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101. Cell Death Dis. 2015-11-06 [PMID: 26539917] (WB, Human)	WB	Human
Lin CL, Cheng YS, Li HH et al. Amyloid-beta suppresses AMP-activated protein kinase (AMPK) signaling and contributes to alpha-synuclein-induced cytotoxicity. Exp Neurol 2016-01-01 [PMID: 26515689]
Lin CW, Chen YS, Lin CC et al. Amiodarone as an autophagy promoter reduces liver injury and enhances liver regeneration and survival in mice after partial hepatectomy. Sci Rep. 2015-10-30 [PMID: 26515640] (WB, Mouse)	WB	Mouse
Jiang Q, Li RP, Tang Y et al. Bakkenolide-IIIa Protects Against Cerebral Damage Via Inhibiting NF-kB Activation. CNS Neurosci Ther. 2015-10-28 [PMID: 26511680] (WB, Rat)	WB	Rat
Mahli A, Thasler WE, Patsenker E et al. Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro. Oncotarget 2015-12-08 [PMID: 26497211]
Venant H, Rahmaniyan M, Jones EE et al. The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo. Mol Cancer Ther 2015-12-01 [PMID: 26494858]
Lytvynchuk L, Sergienko A, Lavrenchuk G, Petrovski G Antiproliferative, Apoptotic, and Autophagic Activity of Ranibizumab, Bevacizumab, Pegaptanib, and Aflibercept on Fibroblasts: Implication for Choroidal Neovascularization. J Ophthalmol 2015-09-27 [PMID: 26491557]
Jo DS, Bae DJ, Park SJ et al. Pexophagy is induced by increasing peroxisomal reactive oxygen species in 1'10-phenanthroline-treated cells. Biochem Biophys Res Commun 2015-11-13 [PMID: 26453011]
Chandrika BB, Yang C, Ou Y et al. Endoplasmic Reticulum Stress-Induced Autophagy Provides Cytoprotection from Chemical Hypoxia and Oxidant Injury and Ameliorates Renal Ischemia-Reperfusion Injury. PLoS One 2015-01-01 [PMID: 26444017] (ICC/IF)	ICC/IF
Fan XY, Tian C, Wang H et al. Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection. Sci Rep 2015-01-01 [PMID: 26423766]
Delaney JR, Patel C, McCabe KE et al. A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer. Oncotarget 2015-10-13 [PMID: 26418751] (WB)	WB
Wei PF, Jin PP, Barui AK et al. Differential ERK activation during autophagy induced by europium hydroxide nanorods and trehalose: Maximum clearance of huntingtin aggregates through combined treatment. Biomaterials 2015-09-11 [PMID: 26409001] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Sorrell SL, Golder ZJ, Johnstone DB, Karet Frankl FE. Renal peroxiredoxin 6 interacts with anion exchanger 1 and plays a novel role in pH homeostasis. Kidney Int. 2015-09-23 [PMID: 26398495] (IHC-P, Mouse)	IHC-P	Mouse
Granato M, Santarelli R, Filardi M et al. The activation of KSHV lytic cycle blocks autophagy in PEL cells. Autophagy 2015-09-21 [PMID: 26391343] (WB, Human)	WB	Human
Koukourakis MI, Kalamida D, Giatromanolaki A et al. Autophagosome Proteins LC3A, LC3B and LC3C Have Distinct Subcellular Distribution Kinetics and Expression in Cancer Cell Lines. PLoS One 2015-01-01 [PMID: 26378792] (WB, Human)	WB	Human
Du TT, Wang L, Duan CL et al. GBA deficiency promotes SNCA/a-synuclein accumulation through autophagic inhibition by inactivated PPP2A. Autophagy 2015-09-17 [PMID: 26378614] (WB, Mouse)	WB	Mouse
Keatinge M, Bui H, Menke A et al. Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death. Hum. Mol. Genet. 2015-09-16 [PMID: 26376862] (WB, Zebrafish)	WB	Zebrafish
Pellegrini C, Columbaro M, Capanni C et al. All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype. Oncotarget 2015-10-06 [PMID: 26359359] (WB)	WB
You Dalsan, Kim Yunlim, Jang Myoung Jin et al. KML001 Induces Apoptosis and Autophagic Cell Death in Prostate Cancer Cells via Oxidative Stress Pathway. PloS One 2015-01-01 [PMID: 26352139] (WB, Mouse)	WB	Mouse
Granato M, Gilardini Montani MS, Filardi M et al. Capsaicin triggers immunogenic PEL cell death, stimulates DCs and reverts PEL-induced immune suppression. Oncotarget 2015-10-06 [PMID: 26338963]
Sibony Michal, Abdullah Majd, Greenfield Laura et al. Microbial Disruption of Autophagy Alters Expression of the RISC Component AGO2, a Critical Regulator of the miRNA Silencing Pathway. Inflammatory Bowel Diseases 2015-01-01 [PMID: 26332312] (WB, Mouse)	WB	Mouse
Chen CM, Syu JP, Way TD et al. BC3EE2,9B, a synthetic carbazole derivative, upregulates autophagy and synergistically sensitizes human GBM8901 glioblastoma cells to temozolomide. Int. J. Mol. Med. 2015-09-01 [PMID: 26329365] (ICC/IF, WB, Human) Details: LC3 antiboldy was used for WB and ICC-IF assays in experiments involving BC3EE2,9B, a synthetic carbazole derivative, effects on glioblastoma cell lines GBM8901 and GBM8401, and human normal skin cell line Detroit 551 cells.	ICC/IF, WB	Human
Tsukahara T, Haniu H. The PTB-Associated Splicing Factor/Peroxisome Proliferator-Activated Receptor Gamma Axis Regulates Autophagosome Formation in Human Pancreatic Cancer Cells BioResearch Open Access 2015-07-02 [PMID: 26309807] (WB, Human) Details: LC3 antibody was used for WB on lysates of human pancreatic cancer cells lines MIA-PaCa-2 and Panc-1 that were subjected to treatoments ith control siRNA or PSF siRNA (Figure 3C). WB was also performed on Panc-1 cells transfected with a pcDNA3.1 empty vector or vector containing PSF (Figure 3D).	WB	Human
Pal I, Parida S, Prashanth Kumar BN et al. Blockade of autophagy enhances proapoptotic potential of BI-69A11, a novel Akt inhibitor, in colon carcinoma. Eur. J. Pharmacol. 2015-08-22 [PMID: 26306675] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Yadav RK, Lee GH, Lee HY et al. TMBIM6 (transmembrane BAX inhibitor motif containing 6) Enhances Autophagy and Reduces Renal Dysfunction in a Cyclosporine A-induced nephrotoxicity model. Autophagy. 2015-08-25 [PMID: 26305401] (WB, Human)	WB	Human
Moreau K, Ghislat G, Hochfeld W et al. Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy. Nat Commun. 2015-08-20 [PMID: 26289944] (WB, Human, Mouse)	WB	Human, Mouse
El-Mashed S, O'Donovan TR, Kay EW et al. LC3B globular structures correlate with survival in esophageal adenocarcinoma. BMC Cancer. 2015-08-12 [PMID: 26265176] (IHC-P, Human)	IHC-P	Human
Li T, Sun KJ, Wang HD et al. Tert-butylhydroquinone Ameliorates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Mice by Enhancing Nrf2-Independent Autophagy. Neurochem. Res. 2015-09-01 [PMID: 26260377] (WB, Mouse)	WB	Mouse
Lee YH, Chen HY, Su LJ, Chueh PJ. Sirtuin 1 (SIRT1) Deacetylase Activity and NAD(+)/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death. J. Agric. Food Chem. 2015-08-26 [PMID: 26255724] (WB, Human) Details: ATG7 antibody was use for WB on lysates of MRC-5 normal human foetal lung fibroblast cells and adenocarcinomic human alveolar basal epithelial cell line A549 that were treated or not with Capsaicin or ethanol.	WB	Human
Yakoub AM, Shukla D. Basal Autophagy Is Required for Herpes simplex Virus-2 Infection. Sci Rep. 2015-08-07 [PMID: 26248741] (WB, Human)	WB	Human
Triplett JC, Tramutola A, Swomley A et al. Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity. Biochim. Biophys. Acta. 2015-10-01 [PMID: 26248058] (WB, Rat) Details: LC3B/MAP1LC3B antibody was used for WB detection of LC3-I and LC3-II in brain tissues from naked mole-rats of different different age groups (Fig. 8 ).	WB	Rat
Xiong X, Wu M, Zhang H et al. Atg5 siRNA inhibits autophagy and enhances norcantharidin-induced apoptosis in hepatocellular carcinoma. Int. J. Oncol. 2015-07-24 [PMID: 26240015] (WB, Human)	WB	Human
Streeter A, Menzies FM, Rubinsztein DC. LC3-II Tagging and Western Blotting for Monitoring Autophagic Activity in Mammalian Cells. Methods Mol. Biol. 2015-08-03 [PMID: 26235065] (WB, Human)	WB	Human
Ngoh EN, Brugger HK, Monajemi M et al. The Crohn's disease-associated polymorphism in ATG16L1 (rs2241880) reduces SHIP gene expression and activity in human subjects. Genes Immun. 2015-07-30 [PMID: 26226011] (WB, Human, Mouse)	WB	Human, Mouse
Matta SK, Kumar D et al. AKT mediated glycolytic shift regulates autophagy in classically activated macrophages Int. J. Biochem. Cell Biol. 2015-07-26 [PMID: 26222186] (WB, Mouse)	WB	Mouse
Chesser AS, Ganeshan V, Yang J, Johnson GV et al. Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons Nutr Neurosci. 2015-07-24 [PMID: 26207957]
Wu HM, Jiang ZF, Ding PS et al. Hypoxia-induced autophagy mediates cisplatin resistance in lung cancer cells Sci Rep. 2015-07-23 [PMID: 26201611] (WB, Human)	WB	Human
Granato M, Chiozzi B, Filardi MR et al. Tyrosine kinase inhibitor tyrphostin AG490 triggers both apoptosis and autophagy by reducing HSF1 and Mcl-1 in PEL cells Cancer Lett. 2015-07-01 [PMID: 26184999] (WB, Human)	WB	Human
Herpin A, Englberger E, Zehner M et al. Defective autophagy through epg5 mutation results in failure to reduce germ plasm and mitochondria. FASEB J 2015-10-01 [PMID: 26183773]
Wang IK, Sun KT, Tsai TH et al. MiR-20a-5p mediates hypoxia-induced autophagy by targeting ATG16L1 in ischemic kidney injury Life Sci. 2015-07-10 [PMID: 26165754] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Tong Y, Sun Y et al. Phospholipid transfer protein (PLTP) deficiency accelerates memory dysfunction through altering amyloid precursor protein (APP) processing in a mouse model of Alzheimer's disease. Hum Mol Genet 2015-01-10 [PMID: 26160914] (IHC, Mouse)	IHC	Mouse
Shin JH, Bae DJ, Kim ES et al. Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells Biomol Ther (Seoul). 2015-07-01 [PMID: 26157548] (WB, Human)	WB	Human
Schiattarella GG, Cerulo G, De Pasquale V et al. The Murine Model of Mucopolysaccharidosis IIIB Develops Cardiopathies over Time Leading to Heart Failure PLoS ONE. 2015-07-07 [PMID: 26147524] (WB, Mouse) Details: LC3 antibody was used for WB analysis of heart/cardiac tissue lysates from WT and alpha-N-acetylglucosaminidase(NAGLU) -/- mice (Fig 6).	WB	Mouse
Agarwal S, Tiwari SK, Seth B et al. Activation of autophagic flux against xenoestrogen Bisphenol-A induced hippocampal neurodegeneration via AMPK/mTOR pathways J. Biol. Chem. 2015-07-02 [PMID: 26139607] (WB, Rat)	WB	Rat
Hrabeta J, Groh T, Khalil MA et al. Vacuolar-ATPase-mediated intracellular sequestration of ellipticine contributes to drug resistance in neuroblastoma cells Int. J. Oncol. 2015-06-29 [PMID: 26134421] (WB, Human) Details: LC3 antibody was used for WB assay in experiments involving ellipticine-resistant UKF-NB-4ELLI cell line and its parental ellipticine-sensitive human neuroblastoma UKF-NB-4 cell line.	WB	Human
Lee HO, Mustafa A, Hudes GR, Kruger WD. Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells. PLoS One. 2015-07-02 [PMID: 26134285] (WB, Human)	WB	Human
Campbell GR, Rawat P, Bruckman RS, Spector SA. Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration PLoS Pathog. 2015-06-01 [PMID: 26115100] (WB, Human)	WB	Human
Godar RJ, Ma X, Liu H et al. Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury. Autophagy 2015-01-01 [PMID: 26103523] (WB)	WB
Liu KE, Frazier WA. Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy PLoS ONE. 2015-06-24 [PMID: 26102349] (WB, Human)	WB	Human
Zhang L, Ding K, Wang H et al. Traumatic Brain Injury-Induced Neuronal Apoptosis is Reduced Through Modulation of PI3K and Autophagy Pathways in Mouse by FTY720 Cell. Mol. Neurobiol. 2015-06-23 [PMID: 26099903] (WB, Mouse)	WB	Mouse
He B, Zhang N, Zhao R. Dexamethasone Downregulates SLC7A5 Expression and Promotes Cell Cycle Arrest, Autophagy and Apoptosis in BeWo Cells. J Cell Physiol 2016-01-01 [PMID: 26094588]
Shelby Shameka J, Angadi Pavan S, Zheng Qiong-Duon et al. Hypoxia inducible factor 1a contributes to regulation of autophagy in retinal detachment. Experimental Eye Research 2015-01-01 [PMID: 26093278] (IHC, Rat)	IHC	Rat
Cheng D, Weckerle A, Yu Y et al. Biogenesis and cytotoxicity of APOL1 renal-risk variant proteins in hepatocytes and hepatoma cells J. Lipid Res. 2015-06-18 [PMID: 26089538]
Park S, Choi SG, Yoo SM et al. Pyruvate stimulates mitophagy via PINK1 stabilization Cell. Signal. 2015-06-09 [PMID: 26071202]
Guo ML, Liao K, Periyasamy P et al. Cocaine-mediated microglial activation involves the ER stress-autophagy axis. Autophagy 2015-01-01 [PMID: 26043790] (WB)	WB
Zhang R, Li Y, Wang Z et al. Interference with HMGB1 increases the sensitivity to chemotherapy drugs by inhibiting HMGB1-mediated cell autophagy and inducing cell apoptosis. Tumour Biol 2015-06-04 [PMID: 26040768]
Teng AC, Miyake T, Yokoe S et al. Metformin increases degradation of phospholamban via autophagy in cardiomyocytes Proc Natl Acad Sci U S A. 2015-06-08 [PMID: 26040000] (WB, Human)	WB	Human
Dangi A, Huang C, Tandon A et al. Endotoxin-Stimulated Rat Hepatic Stellate Cells Induce Autophagy in Hepatocytes as a Survival Mechanism. J Cell Physiol 2015-05-29 [PMID: 26031389] (Rat)		Rat
Li L, Wang X, Wang L et al. Mammalian target of rapamycin overexpression antagonizes chronic hypoxia-triggered pulmonary arterial hypertension via the autophagic pathway. Int J Mol Med 2015-07-01 [PMID: 26017061]
Sun T, Li X, Zhang P et al. Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth. Nat Commun. 2015-05-26 [PMID: 26008601] (WB, Human)	WB	Human
Namkoong S, Lee KI, Lee JI et al. The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flux via interaction with the vacuolar ATPase. Autophagy. 2015-05-04 [PMID: 25951193] (WB, Human)	WB	Human
Mintern JD, Macri C, Chin WJ et al. Differential use of autophagy by primary dendritic cells specialised in cross-presentation. Autophagy. 2015-05-07 [PMID: 25950899] (WB, Human, Mouse)	WB	Human, Mouse
Jung R, Choi JH, Lee HJ et al. Effect of Immortalization-Upregulated Protein-2 (IMUP-2) on Cell Death of Trophoblast. Balsaenggwa Saengsig 2013-06-01 [PMID: 25949126]
Kim Y, Kang YS, Lee NY et al. Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency. Autophagy. 2015-05-04 [PMID: 25946189] (WB, Mouse)	WB	Mouse
Gavilan E, Giraldez S, Sanchez-Aguayo I et al. Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3B dependent mechanism. Sci Rep. 2015-05-05 [PMID: 25941117] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Carson CC, Moschos SJ, Edmiston SN et al. IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma. Clin. Cancer Res. 2015-05-01 [PMID: 25934889] (WB, Human)	WB	Human
Shibuya Y, Niu Z, Bryleva EY et al. Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage Neurobiol. Aging 2015-01-01 [PMID: 25930235] (WB, Mouse)	WB	Mouse
Yao J, Zheng K, Li C et al. Interference of Notch1 inhibits the growth of glioma cancer cells by inducing cell autophagy and down-regulation of Notch1-Hes-1 signaling pathway. Med. Oncol. 2015-05-01 [PMID: 25920606] (WB, Human)	WB	Human
Ariadna Laguna, Nicoletta Schintu, Andre Nobre et al. Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinsons disease. Nature Neuroscience 2015-04-27 [PMID: 25915474] (WB, Mouse)	WB	Mouse
Wang S, Livingston MJ, Su Y, Dong, Z. Reciprocal regulation of cilia and autophagy via the MTOR and proteasome pathways Autophagy 2015-04-23 [PMID: 25906314] (WB, Human)	WB	Human
Cabrera S, Maciel M, Herrera I et al. Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis Autophagy 2015-04-23 [PMID: 25906080] (ICC/IF, Mouse)	ICC/IF	Mouse
Levi B Watkin, Birthe Jessen, Wojciech Wiszniewski et al. COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. Nature Genetics 2015-04-20 [PMID: 25894502] (IHC, Human)	IHC	Human
Yakoub AM, Shukla D. Herpes Simplex Virus-1 Fine-Tunes Host's Autophagic Response to Infection: A Comprehensive Analysis in Productive Infection Models PLoS ONE 2015-04-21 [PMID: 25894397] (WB, Human)	WB	Human
Yakoub AM, Shukla D. Autophagy Stimulation Abrogates Herpes simplex Virus-1 Infection Sci Rep 2015-04-10 [PMID: 25856282] (WB, Human, Mouse)	WB	Human, Mouse
Kett LR, Stiller B, Bernath MM et al. alpha-Synuclein-Independent Histopathological and Motor Deficits in Mice Lacking the Endolysosomal Parkinsonism Protein Atp13a2 J. Neurosci. 2015-04-08 [PMID: 25855184] (WB, Mouse)	WB	Mouse
Jimenez-Sanchez M, Lam W, Hannus M et al. siRNA screen identifies QPCT as a druggable target for Huntington's disease. Nat Chem Biol 2015-05-01 [PMID: 25848931]
Tam BT, Pei XM, Yu AP et al. Autophagic adaptation is associated with exercise-induced fibre-type shifting in skeletal muscle Acta Physiol (Oxf) 2015-04-06 [PMID: 25847142] (IHC-Fr, WB, Rat)	IHC-Fr, WB	Rat
Pajuelo-Reguera D, Alan L et al. Dichloroacetate stimulates changes in the mitochondrial network morphology via partial mitophagy in human SH-SY5Y neuroblastoma cells. Int J Oncol 2015-08-04 [PMID: 25846762] (WB, Human)	WB	Human
Chandler HL, Gervais KJ, Lutz EA et al. Cyclosporine A prevents ex vivo PCO formation through induction of autophagy-mediated cell death Exp. Eye Res. 2015-03-31 [PMID: 25839646] (IHC, WB, Canine)	IHC, WB	Canine
Yue M, Hinkle KM, Davies P et al. Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice Neurobiol. Dis. 2015-03-31 [PMID: 25836420] (WB, Mouse)	WB	Mouse
Gonnella R, Granato M, Farina A et al. PKC theta and p38 MAPK activate the EBV lytic cycle through autophagy induction. Biochim. Biophys. Acta. 2015-03-27 [PMID: 25827954] (WB, Human)	WB	Human
Liu S, Li X. Autophagy inhibition enhances sensitivity of endometrial carcinoma cells to paclitaxel Int. J. Oncol. 2015-06-01 [PMID: 25825088] (WB, Human)	WB	Human
Van Nostrand JL, Brisac A, Mello SS et al. The p53 Target Gene Siva Enables Non-Small Cell Lung Cancer Development Cancer Discov 2015-03-26 [PMID: 25813352] (WB, Mouse)	WB	Mouse
Roux C, Aligny C, Lesueur C et al. NMDA receptor blockade in the developing cortex induces autophagy-mediated death of immature cortical GABAergic interneurons: An ex vivo and in vivo study in Gad67-GFP mice. Exp. Neurol. 2015-03-17 [PMID: 25795167] (WB, Mouse)	WB	Mouse
Labouba I, Poisson A, Lafontaine J et al. The RelB alternative NF-kappaB subunit promotes autophagy in 22Rv1 prostate cancer cells in vitro and affects mouse xenograft tumor growth in vivo. Cancer Cell Int 2014-01-01 [PMID: 25788857] (WB, Mouse)	WB	Mouse
Magne J, Gustafsson P et al. ATG16L1 Expression in Carotid Atherosclerotic Plaques Is Associated With Plaque Vulnerability. Arterioscler Thromb Vasc Biol 2015-01-05 [PMID: 25767270] (WB, Human)	WB	Human
Suarez G, Romero-Gallo J, Piazuelo MB et al. Modification of Helicobacter pylori Peptidoglycan Enhances NOD1 Activation and Promotes Cancer of the Stomach Cancer Res. 2015-03-02 [PMID: 25732381] (WB, Human) Details: LC3B/MAP1LC3B antibody used for WB on lysates of gastric adenocarcinoma cell line namely AGS cells co-cultured or not with Helicobacter pylori ( WT strain 7.13 or its pgdA- mutant ). The WB assay involved 12% SDS-PAGE gel, protein transfer to PVDF membrane, blocking of membranes with 1% BSA, incubation with primary antibody at 1:500 dilution for 1 hour and detection with anti-rabbit HRP-conjugated secondary - ECL method (Figure 2B)	WB	Human
She T, Qu L, Wang L et al. Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Cancer Cell Growth by S Phase Arrest, Apoptosis and Autophagy via Redox-dependent ERK1/2 Pathway Cancer Prev Res (Phila) 2015-03-02 [PMID: 25732255] (WB, Human) Details: LC3B/MAP1LC3B antibody used for WB on lysates of human stomach/gastric adenocarcinoma cell line AGS and human colorectal adenocarcinoma cell line HT-29 treated or not with supernatant of the water-soluble extract of Sarsaparilla/SW (Smilax Glabra Rhizome). WB also performed on lysates of these cells treated with SW and/or GSH, U0126 (selective inhibitor of both MEK1 and MEK2) or PD98059 (selective inhibitor of MAPK/ERK kinase).	WB	Human
Medina DL, Di Paola S, Peluso I et al. Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB Nat. Cell Biol. 2015-02-27 [PMID: 25720963] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Hsuan SW, Chyau CC, Hung HY et al. The induction of apoptosis and autophagy by Wasabia japonica extract in colon cancer Eur J Nutr 2015-02-27 [PMID: 25720497] (WB, Human)	WB	Human
Pedro JM, Wei Y, Sica V et al. BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy. Autophagy 2015-01-01 [PMID: 25715028] (IP, Mouse)	IP	Mouse
Ulbricht A, Gehlert S, Leciejewski B et al. Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle Autophagy. 2015-02-25 [PMID: 25714469] (IHC, Human)	IHC	Human
Sanjurjo L, Amezaga N, Aran G et al. The human CD5L/AIM-CD36 axis: A novel autophagy inducer in macrophages that modulates inflammatory responses Autophagy. 2015-02-25 [PMID: 25713983] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Chen JH, Zhang P, Chen WD et al. ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells Autophagy. 2015-02-20 [PMID: 25701194] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Jabir MS, Hopkins L, Ritchie ND et al. Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy. Autophagy 2015-01-01 [PMID: 25700738] (WB)	WB
Kim ES, Shin JH, Park SJ et al. Inhibition of autophagy suppresses sertraline-mediated primary ciliogenesis in retinal pigment epithelium cells PLoS ONE. 2015-02-12 [PMID: 25671433] (WB, Human)	WB	Human
Kommaddi RP, Jean-Charles PY, Shenoy SK. Phosphorylation of the deubiquitinase USP20 by Protein Kinase A regulates post-endocytic trafficking of beta 2 adrenergic receptors to autophagosomes during physiological stress J. Biol. Chem. 2015-02-09 [PMID: 25666616] (WB, Human)	WB	Human
Ito S, Tanaka Y, Oshino R et al. GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy Sci Rep. 2015-02-09 [PMID: 25659802] (WB, Mouse)	WB	Mouse
Lin HH. In Vitro and in Vivo Atheroprotective Effects of Gossypetin against Endothelial Cell Injury by Induction of Autophagy. Chem Res Toxicol. 2015-01-29 [PMID: 25622137]
Yuan N, Song L, Lin W et al. Autophagy collaborates with ubiquitination to downregulate oncoprotein E2A/Pbx1 in B-cell acute lymphoblastic leukemia. Blood Cancer J. 2015-01-24 [PMID: 25615280] (WB, Mouse)	WB	Mouse
Yang M, Liu L, Xie M et al. Poly-ADP-ribosylation of HMGB1 regulates TNFSF10/TRAIL resistance through autophagy Autophagy. 2015-01-21 [PMID: 25607248]
Yan Y, Jiang W, Liu L et al. Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome Cell. 2015-01-15 [PMID: 25594175] (WB, Mouse)	WB	Mouse
Baker B, Geng S, Chen K et al. Alteration of lysosome fusion and low-grade inflammation mediated by super-low dose endotoxin . J Biol Chem 2015-01-13 [PMID: 25586187] (IHC, Mouse) Details: Using the Alexa Fluor (R) 488 conjugated version of NB100-2220, catalog number NB100-2220AF488.	IHC	Mouse
Xu Y, Tian C, Sun J et al. FBXW7-Induced MTOR Degradation Forces Autophagy to Counteract Persistent Prion Infection Mol. Neurobiol. 2015-01-13 [PMID: 25579381] (WB, Mouse) Details: LC3B/MAP1LC3B antibody used for WB on SMB-PS and SMB-S15 cell lines (murine cell line, persistent prion infection/scrapie-infected) - data is shown in Fig 1a and higher levels of LC3II were observed in SMB-S15 cells compared to SMB-P.	WB	Mouse
Maycotte P, Jones KL, Goodall ML et al. Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion. Mol Cancer Res 2015-04-01 [PMID: 25573951]
Liu S, Sarkar C, Dinizo M et al. Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death. Cell Death Dis 2015-01-01 [PMID: 25569099] (Rat)		Rat
Bueno M, Lai Y, Romero Y et al. PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. J. Clin. Invest. 2014-12-22 [PMID: 25562319] (IHC, Mouse)	IHC	Mouse
Sykora P, Misiak M, Wang Y et al. DNA polymerase b deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes. Nucleic Acids Res 2014-12-30 [PMID: 25552414] (WB, Mouse) Details: Using the DyLight 550 conjugated version of NB100-304, catalog number NB100-304R.	WB	Mouse
Sampaolo S, Esposito T, Gianfrancesco F et al. A novel GBE1 mutation and features of polyglucosan bodies autophagy in adult polyglucosan body disease. Neuromuscular Disorders 2014-11-18 [PMID: 25544507]
Campbell GR, Bruckman RS, Chu Y, Spector SA. Autophagy Induction by Histone Deacetylase Inhibitors Inhibits HIV Type 1. J. Biol. Chem. 2014-12-24 [PMID: 25540204] (WB, Human)	WB	Human
Suarez Christopher D, Deng Xuehong, Hu Chang-Deng. Targeting CREB inhibits radiation-induced neuroendocrine differentiation and increases radiation-induced cell death in prostate cancer cells. Am J Cancer Res. 2014-11-19 [PMID: 25520873] (WB)	WB
Krishnaswamy S, Lin Y, Rajamohamedsait WJ et al. Antibody-derived in vivo imaging of tau pathology. J. Neurosci. 2014-12-10 [PMID: 25505335] (IHC, Mouse)	IHC	Mouse