Losing memory: Toxicity from mutant APP and amyloid beta explain the hippocampal neuronal damage in Alzheimer's disease

Application Focus: I see an increase in LC3, now what?

Epigenetic Control of Autophagy

Crosstalk Between Oxidative Stress and Autophagy

Autophagy inhibition in pediatrics: One physician-scientist’s brave decision

Cleaner gone bad: Autophagy regulates motor neuron loss in spinal muscular atrophy

Cross-talk between proteasome degradation and lysosomal degradation

Brain size matters: MTOR regulates autophagy and number of cortical interneurons

How to switch from apoptotic to necroptotic cell death? Answer: Autophagy!

By Christina Towers, PhD.

Application guide: Methods to monitor Autophagy

Autophagy is an essential process that cells utilize to degrade and recycle damaged material and fuel metabolism, especially under stress.  The process is evolutionarily conserved and complex, relying on over 20 key proteins. Induction of autophagy is mediated by the formation of the ULK and BECLIN complexes, the latter of which includes BH3-containing proteins and AMBRA1, resulting in the formation of a double membrane phagophore structure.