Caspase-3 Antibody [Unconjugated] - Active

Caspase‑3 was detected in immersion fixed anti-FAS treated Jurkat human acute T cell leukemia cell line using 0.3 µg/mL Human/Mouse Active Caspase‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) for 3 hours at room temperature. Cells were stained (red) and counterstained (green). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Caspase‑3 was detected in immersion fixed paraffin-embedded sections of human colon cancer tissue using Rabbit Anti-Human/Mouse Active Caspase‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) at 1 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Rabbit IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC003). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Caspase‑3 was detected in immersion fixed Jurkat human acute T cell leukemia cell line stimulated with staurosporin using Human/Mouse Active Caspase‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Rabbit IgG Secondary Antibody (yellow; Catalog # NL004) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

• Reactivity: Hu, Mu
• Applications: IHC, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: LYOPH

Caspase-3 Antibody [Unconjugated] - Active Summary

• Immunogen: KLH-coupled human Caspase-3 synthetic peptide
  CRGTELDCGIETD
  Accession # P42574
• Specificity: Distinguishes apoptotic cells from non-apoptotic cells in immunohistochemistry. Detects the p17 subunit of Caspase-3, but does not detect the precursor form in Western blot. We recommend R&D Systems Affinity Purified Anti-Caspase-3 (Catalog # AF-605-NA) or Monoclonal Anti-Cleaved-Caspase-3 (Catalog # MAB835) for Western blot applications.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CASP3
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1-15 ug/mL
  • Immunocytochemistry 5-15 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Caspase-3 Antibody [Unconjugated] - Active

• Apopain
• apoptosis-related cysteine protease
• CASP3
• CASP-3
• caspase 3, apoptosis-related cysteine peptidase
• Caspase3
• Caspase-3
• CPP32
• CPP-32
• CPP32B
• CPP32SREBP cleavage activity 1
• Cysteine protease CPP32
• EC 3.4.22
• EC 3.4.22.56
• LICE-1
• PARP cleavage protease
• procaspase3
• Protein Yama
• SCA-1
• YAMA

Background

Caspase-3 (Cysteine-aspartic acid protease 3/Casp3; also Yama, apopain and CPP32) is a 29 kDa heterodimer that belongs to the peptidase C14A family of enzymes. It is widely expressed, and considered to be the major executioner caspase in the apoptotic cascade. Human procaspase-3 is a 32 kDa, 277 amino acid (aa) protein and is normally an inactive homodimer. Following cell stress/activation, procaspase-3 undergoes proteolysis to generate an N-terminal 148 aa p17/17 kDa subunit (aa 29-175), plus a 102 aa C-terminal p12/12 kDa subunit. These subunits noncovalently heterodimerize, and associate with another p17/p12 heterodimer to form an active enzyme. There is one potential variant that shows an alternative start site nine aa upstream of the standard start site coupled with a 21 aa substitution for aa 162-277. Over aa 29-175, human and mouse caspase-3 share 87% aa identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Caspase-3 Antibody (AF835)(152)

Publications using AF835

• F Chang, SJ Kong, L Wang, BK Choi, H Lee, C Kim, JM Kim, K Park Targeting Actomyosin Contractility Suppresses Malignant Phenotypes of Acute Myeloid Leukemia Cells Int J Mol Sci, 2020;21(10):. 2020 [PMID: 32422910] (IHC, Mouse)
• J Aldaregia, P Errarte, A Olazagoiti, M Gimeno, JJ Uriz, TR Gershon, I Garcia, A Matheu Erbb4 Is Required for Cerebellar Developmentand Malignant Phenotype of Medulloblastoma Cancers (Basel), 2020;12(4):. 2020 [PMID: 32316671] (ICC, Mouse)
• NJ Yates, KW Feindel, A Mehnert, R Beare, S Quick, D Blache, JJ Pillow, RW Hunt Ex Vivo MRI Analytical Methods and Brain Pathology in Preterm Lambs Treated with Postnatal Dexamethasone � Brain Sci, 2020;10(4):. 2020 [PMID: 32260193] (IHC, Lamb)
• MA Khan, T Shamma, S Kazmi, A Altuhami, HA Ahmed, AM Assiri, DC Broering Hypoxia-induced complement dysregulation is associated with microvascular impairments in mouse tracheal transplants J Transl Med, 2020;18(1):147. 2020 [PMID: 32234039] (IHC, Mouse)
• P Aldaz, M Otaegi-Uga, A Saenz-Anto, M Garcia-Pug, M Moreno-Val, JM Flores, D Gerovska, MJ Arauzo-Bra, N Samprón, A Matheu, E Carrasco-G SOX9 promotes tumor progression through the axis BMI1-p21CIP Sci Rep, 2020;10(1):357. 2020 [PMID: 31941916] (IF, Human)
• A Malhotra, M Castillo-M, BJ Allison, AE Sutherland, I Nitsos, Y Pham, CA McDonald, MC Fahey, GR Polglase, G Jenkin, SL Miller Neurovascular effects of umbilical cord blood-derived stem cells in growth-restricted newborn lambs : UCBCs for perinatal brain injury Stem Cell Res Ther, 2020;11(1):17. 2020 [PMID: 31915068]
• K Boric, S Mardesic, D Martinovic, M Radic, I Tadin Hadj, K Vukojevic, I Kosovic, I Solic, S Zekic Toma, M Saraga-Bab Expression of apoptotic and proliferation factors in gastric mucosa of patients with systemic sclerosis correlates with form of the disease Sci Rep, 2019;9(1):18461. 2019 [PMID: 31804582] (IHC-P, Human)
• LG Jones, A Vaida, LM Thompson, FI Ikuomola, JH Caamaño, MD Burkitt, F Miyajima, JM Williams, BJ Campbell, DM Pritchard, CA Duckworth NF-kappaB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells Cell Death Dis, 2019;10(12):896. 2019 [PMID: 31772152] (IHC, Mouse)
• E Grall, V Gourain, A Naïr, E Martin, MC Birling, JN Freund, I Duluc Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs Cell Death Dis, 2019;10(11):812. 2019 [PMID: 31649239] (IHC-P, Mouse)
• D Aprile, F Fruscione, S Baldassari, M Fadda, D Ferrante, A Falace, E Buhler, J Sartorelli, A Represa, P Baldelli, F Benfenati, F Zara, A Fassio TBC1D24 regulates axonal outgrowth and membrane trafficking at the growth cone in rodent and human neurons Cell Death Differ., 2019;0(0):. 2019 [PMID: 30858606] (ICC, Rat)
• P Antas, L Novellasde, A Kucharska, I Massie, J Carvalho, D Oukrif, E Nye, M Novelli, VSW Li SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating ?-Catenin Nuclear Localization Cell Rep, 2019;26(9):2266-2273.e4. 2019 [PMID: 30811977] (IHC-P, Mouse)
• BA Brown, GM Connolly, CEJ Mill, H Williams, GD Angelini, JL Johnson, SJ George Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells Aging Cell, 2018;0(0):e12844. 2018 [PMID: 30548452] (ICC, Mouse)
• O Bover, T Justo, PNG Pereira, J Facucho-Ol, JM Inácio, JS Ramalho, IJ Domian, JA Belo Loss of Ccbe1 affects cardiac-specification and cardiomyocyte differentiation in mouse embryonic stem cells PLoS ONE, 2018;13(10):e0205108. 2018 [PMID: 30281646] (Flow Cytometry, Mouse)
• RK Zwick, MC Rudolph, BA Shook, B Holtrup, E Roth, V Lei, A Van Keymeu, V Seewaldt, S Kwei, J Wysolmersk, MS Rodeheffer, V Horsley Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation Nat Commun, 2018;9(1):3592. 2018 [PMID: 30181538] (IHC, Mouse)
• M Ouarné, C Bouvard, G Boneva, C Mallet, J Ribeiro, A Desroches-, E Soleilhac, E Tillet, O Peyruchaud, S Bailly BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer J. Exp. Clin. Cancer Res., 2018;37(1):209. 2018 [PMID: 30165893] (IHC-P, Mouse)
• A López-Muño, FE Nicolás, D García-Mor, AB Pérez-Oliv, MI Navarro-Me, MA Hernández-, A Herrera-Es, S Torres-Mar, RM Ruiz-Vázqu, V Garre, V Mulero An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages Sci Rep, 2018;8(1):12802. 2018 [PMID: 30143654] (IHC-P, Zebrafish)
• P Shen, J Chen, M Pan The protective effects of total paeony glycoside on ischemia/reperfusion injury in H9C2 cells via inhibition of the PI3K/Akt signaling pathway Mol Med Rep, 2018;18(3):3332-3340. 2018 [PMID: 30066927] (Western Blot, Rat)
• M Baek, M Kim, JS Lim, LD Morales, J Hernandez, S Mummidi, S Williams-B, IS Jang, AT Tsin, DJ Kim Epidermal-specific deletion of TC-PTP promotes UVB-induced epidermal cell survival through the regulation of Flk-1/JNK signaling Cell Death Dis, 2018;9(7):730. 2018 [PMID: 29955047] (Human)
• ML Piacentino, ME Bronner Intracellular attenuation of BMP signaling via CKIP-1/Smurf1 is essential during neural crest induction PLoS Biol., 2018;16(6):e2004425. 2018 [PMID: 29949573] (IHC-P, Chicken)
• I Cohen, D Zhao, C Bar, VJ Valdes, KL Dauber-Dec, MB Nguyen, M Nakayama, M Rendl, WA Bickmore, H Koseki, D Zheng, E Ezhkova PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification Cell Stem Cell, 2018;22(5):726-739.e7. 2018 [PMID: 29727681] (IHC, Mouse)
• R Barbieri, A Contestabi, MG Ciardo, N Forte, A Marte, P Baldelli, F Benfenati, F Onofri Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice Oncotarget, 2018;9(27):18760-18774. 2018 [PMID: 29721159] (IHC, Mouse)
• E Indersie, KB Hooks, C Capdeviell, M Fabre, N Dugot-Sena, A Desplat, S Lepreux, A Merched, CF Grosset, M Hagedorn Tracking cellular and molecular changes in a species-specific manner during experimental tumor progression in vivo Oncotarget, 2018;9(22):16149-16162. 2018 [PMID: 29662633] (IHC, Human)
• P Srikanth, VN Lagomarsin, CR Muratore, SC Ryu, A He, WM Taylor, C Zhou, M Arellano, TL Young-Pear Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids Transl Psychiatry, 2018;8(1):77. 2018 [PMID: 29643329] (ICC, Mouse)
• PLN da Costa, D Wynne, T Fifis, L Nguyen, M Perini, C Christophi The kallikrein-Kinin system modulates the progression of colorectal liver metastases in a mouse model BMC Cancer, 2018;18(1):382. 2018 [PMID: 29618333] (IHC, Mouse)
• N Antoniou, D Vlachakis, A Memou, E Leandrou, PE Valkimadi, K Melachroin, DB Re, S Przedborsk, WT Dauer, L Stefanis, HJ Rideout A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway Sci Rep, 2018;8(1):3455. 2018 [PMID: 29472595] (ICC, Mouse)
• JM Povedano, P Martinez, R Serrano, Á Tejera, G Gómez-Lópe, M Bobadilla, JM Flores, F Bosch, MA Blasco Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres Elife, 2018;7(0):. 2018 [PMID: 29378675] (IHC-P, Mouse)
• D Skuk, JP Tremblay The Process of Engraftment of Myogenic Cells in Skeletal Muscles of Primates: Understanding Clinical Observations and Setting Directions in Cell Transplantation Research Cell Transplant, 2017;26(11):1763-1779. 2017 [PMID: 29338383] (IHC, Primate)
• N Dreyer-And, AS Almeida, P Jensen, M Kamand, J Okarmus, T Rosenberg, SD Friis, A Martínez S, M Blaabjerg, BW Kristensen, T Skrydstrup, JB Gramsberge, HLA Vieira, M Meyer Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells PLoS ONE, 2018;13(1):e0191207. 2018 [PMID: 29338033] (ICC, Human)
• C Ambrogio, J Köhler, ZW Zhou, H Wang, R Paranal, J Li, M Capelletti, C Caffarra, S Li, Q Lv, S Gondi, JC Hunter, J Lu, R Chiarle, D Santamaría, KD Westover, PA Jänne KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS Cell, 2018;0(0):. 2018 [PMID: 29336889] (IHC-P, Mouse)
• CA Lyon, H Williams, R Bianco, SJ Simmonds, BA Brown, KS Wadey, FCT Smith, JL Johnson, SJ George Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression Sci Rep, 2017;7(1):17342. 2017 [PMID: 29229950] (IHC, Human)
• MK Shim, HY Yoon, S Lee, MK Jo, J Park, JH Kim, SY Jeong, IC Kwon, K Kim Caspase-3/-7-Specific Metabolic Precursor for Bioorthogonal Tracking of Tumor Apoptosis Sci Rep, 2017;7(1):16635. 2017 [PMID: 29192289] (Western Blot, Human)
• M Dezest, M Le Bechec, L Chavatte, V Desauziers, B Chaput, JL Grolleau, P Descargues, C Nizard, S Schnebert, S Lacombe, AL Bulteau Oxidative damage and impairment of protein quality control systems in keratinocytes exposed to a volatile organic compounds cocktail Sci Rep, 2017;7(1):10707. 2017 [PMID: 28878258] (IHC-P, Human)
• M Dezest, M Le Bechec, L Chavatte, V Desauziers, B Chaput, JL Grolleau, P Descargues, C Nizard, S Schnebert, S Lacombe, AL Bulteau Oxidative damage and impairment of protein quality control systems in keratinocytes exposed to a volatile organic compounds cocktail Sci Rep, 2017;7(1):10707. 2017 [PMID: 28878258] (IHC, Human)
• M Dezest, M Le Bechec, L Chavatte, V Desauziers, B Chaput, JL Grolleau, P Descargues, C Nizard, S Schnebert, S Lacombe, AL Bulteau Oxidative damage and impairment of protein quality control systems in keratinocytes exposed to a volatile organic compounds cocktail Sci Rep, 2017;7(1):10707. 2017 [PMID: 28878258] (IHC, Human)
• C Tu, R Xu, M Koleti, J Zoldan Glycogen synthase kinase-3 inhibition sensitizes human induced pluripotent stem cells to thiol-containing antioxidants induced apoptosis Stem Cell Res, 2017;23(0):182-187. 2017 [PMID: 28772167] (Functional Assay, Human)
• DJ Flanagan, N Barker, C Nowell, H Clevers, M Ernst, TJ Phesse, E Vincan Loss of the Wnt receptor Frizzled7 in the gastric epithelium is deleterious and triggers rapid repopulation in vivo Dis Model Mech, 2017;0(0):. 2017 [PMID: 28600348] (IHC, Mouse)
• F Oozeer, LL Yates, C Dean, CJ Formstone A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin Sci Rep, 2017;7(1):1880. 2017 [PMID: 28500339] (IHC, Mouse)
• F Cartier, E Indersie, S Lesjean, J Charpentie, KB Hooks, A Ghousein, A Desplat, N Dugot-Sena, V Trézéguet, F Sagliocco, M Hagedorn, CF Grosset New tumor suppressor microRNAs target glypican-3 in human liver cancer Oncotarget, 2017;0(0):. 2017 [PMID: 28476031] (IHC, Chicken)
• LA Murray, R Dunmore, A Camelo, CA Da Silva, MJ Gustavsson, DM Habiel, TL Hackett, CM Hogaboam, MA Sleeman, DA Knight Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium Respir. Res., 2017;18(1):82. 2017 [PMID: 28468623] (IHC, Mouse)
• Lynne A Murray, Rebecca Dunmore, Ana Camelo, Carla A Da Silva, Malin J Gustavsso, David M Habiel, Tillie L Hackett, Cory M Hogaboam, Matthew A Sleeman, Darryl A Knight Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium. Respiratory Research, 2017;0(0):1465-993X. 2017 [PMID: 28468623] (IHC, Mouse)
• AA Chassot, M Le Rolle, M Jourden, MM Taketo, NB Ghyselinck, MC Chaboissie Constitutive WNT/CTNNB1 activation triggers spermatogonial stem cell proliferation and germ cell depletion Dev. Biol., 2017;0(0):. 2017 [PMID: 28456466] (IHC-P, Mouse)
• JY Jang, SY Choi, I Park, DY Park, K Choe, P Kim, YK Kim, BJ Lee, M Hirashima, Y Kubota, JW Park, SY Cheng, A Nagy, YJ Park, K Alitalo, M Shong, GY Koh VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis EMBO Mol Med, 2017;0(0):. 2017 [PMID: 28438786] (IHC, Mouse)
• S Grasso, J Chapelle, V Salemme, S Aramu, I Russo, N Vitale, L Verdun di, K Dallaglio, I Castellano, A Amici, G Centonze, N Sharma, S Lunardi, S Cabodi, F Cavallo, A Lamolinara, L Stramucci, E Moiso, P Provero, A Albini, A Sapino, J Staaf, PP Di Fiore, G Bertalot, S Pece, D Tosoni, S Confalonie, M Iezzi, P Di Stefano, E Turco, P Defilippi The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries Nat Commun, 2017;8(0):14797. 2017 [PMID: 28300085] (IHC, Mouse)
• JC Klein, K Moses, G Zelinskyy, S Sody, J Buer, S Lang, I Helfrich, U Dittmer, CJ Kirschning, S Brandau Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth Nat Commun, 2017;8(0):14600. 2017 [PMID: 28300057] (IHC, Mouse)
• KR Hughes, LC Harnisch, C Alcon-Gine, S Mitra, CJ Wright, J Ketskemety, D van Sinder, AJ Watson, LJ Hall Bifidobacterium breve reduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD88-dependent manner Open Biol, 2017;7(1):. 2017 [PMID: 28123052] (IHC-P, Mouse)
• T Revenco, G Lapouge, V Moers, S Broh‚e, PA Sotiropoul Low Dose Radiation Causes Skin Cancer In Mice And Has A Differential Effect on Distinct Epidermal Stem Cells Stem Cells, 2017;0(0):. 2017 [PMID: 28100039] (IHC-P, Mouse)
• Y He, H Huang, C Farischon, D Li, Z Du, K Zhang, X Zheng, S Goodin Combined effects of atorvastatin and aspirin on growth and apoptosis in human prostate cancer cells Oncol. Rep, 2017;37(2):953-960. 2017 [PMID: 28075470] (ICC, Human)
• Autophagy deficient keratinocytes display increased DNA damage, senescence and aberrant lipid composition after oxidative stress in vitro and in vivo Redox Biol, 2016;11(0):219-230. 2016 [PMID: 28012437] (Western Blot, Mouse)
• cMyc Regulates the Size of the Premigratory Neural Crest Stem Cell Pool Cell Rep, 2016;17(10):2648-2659. 2016 [PMID: 27926868] (IHC, Mouse)
• Simon X Liang Proliferation, differentiation and migration of SCA1(-)/CD31(-) cardiac side population cells in vitro and in vivo Int. J. Cardiol., 2016;0(0):. 2016 [PMID: 27847151] (IHC, Mouse)
• Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations PLoS ONE, 2016;11(11):e0166053. 2016 [PMID: 27832104] (IHC, Human)
• Karina S Cramer Axonal Cleaved Caspase-3 Regulates Axon Targeting and Morphogenesis in the Developing Auditory Brainstem Front Neural Circuits, 2016;10(0):84. 2016 [PMID: 27822180] (IHC, Chicken)
• CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex Stem Cell Reports, 2016;7(1):69-79. 2016 [PMID: 27411104] (IHC, Mouse)
• M-C De Cian Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary Oncogene, 2016;0(0):. 2016 [PMID: 27270435] (IHC-P, Mouse)
• Defining the cellular lineage hierarchy in the interfollicular epidermis of adult skin Nat. Cell Biol., 2016;18(6):619-31. 2016 [PMID: 27183471] (IHC, Mouse)
• Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice J Neurosci, 2016;36(17):4758-70. 2016 [PMID: 27122034] (IHC, Mouse)
• F Lorenzi, R Babaei-Jad, J Sheard, B Spencer-De, AS Nateri Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture Mol Ther Methods Clin Dev, 2016;3(0):16024. 2016 [PMID: 27110583] (IHC-P, Mouse)
• SR Berkowicz, TJ Featherby, Z Qu, A Giousoh, NA Borg, JI Heng, JC Whisstock, PI Bird Brinp1 (-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density Mol Autism, 2016;7(0):22. 2016 [PMID: 27042284] (IHC-Fr, Mouse)
• Jacob F, Yonis A, Cuello F, Luther P, Schulze T, Eder A, Streichert T, Mannhardt I, Hirt M, Schaaf S, Stenzig J, Force T, Eschenhagen T, Hansen A Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue. PLoS ONE, 2016;11(2):e0145937. 2016 [PMID: 26840448] (IHC-P, Rat)
• Amelkina O, Zschockelt L, Painer J, Serra R, Villaespesa F, Braun B, Jewgenow K Apoptosis-Related Factors in the Luteal Phase of the Domestic Cat and Their Involvement in the Persistence of Corpora Lutea in Lynx. PLoS ONE, 2015;10(11):e0143414. 2015 [PMID: 26599641] (IHC-P, Feline)
• JD Aridas, CA McDonald, MC Paton, T Yawno, AE Sutherland, I Nitsos, Y Pham, M Ditchfield, MC Fahey, F Wong, A Malhotra, M Castillo-M, K Bhakoo, EM Wallace, G Jenkin, SL Miller Cord blood mononuclear cells prevent neuronal apoptosis in response to perinatal asphyxia in the newborn lamb J. Physiol. (Lond.), 2016;594(5):1421-35. 2016 [PMID: 26527561] (IHC-P, Mouse)
• Wong J, Chen L, Huang Y, Sehba F, Friedel R, Zou H Attenuation of Cerebral Ischemic Injury in Smad1 Deficient Mice. PLoS ONE, 2015;10(8):e0136967. 2015 [PMID: 26317208] (IHC-Fr, Mouse)
• Quereda V, Porlan E, Canamero M, Dubus P, Malumbres M An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress. Cell Death Differ, 2015;23(3):430-41. 2015 [PMID: 26292757] (IHC-P, Mouse)
• Douglas T, Champagne C, Morizot A, Lapointe J, Saleh M The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice. J Immunol, 2015;195(5):2365-73. 2015 [PMID: 26216893] (IHC-P, Mouse)
• Levet S, Ouarne M, Ciais D, Coutton C, Subileau M, Mallet C, Ricard N, Bidart M, Debillon T, Faravelli F, Rooryck C, Feige J, Tillet E, Bailly S BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus. Proc Natl Acad Sci U S A, 2015;112(25):E3207-15. 2015 [PMID: 26056270] (IHC, Mouse)
• Sun H, Lou Y, Porturas T, Morrissey S, Luo G, Qi J, Ruan Q, Shi S, Chen Y Exacerbated experimental colitis in TNFAIP8-deficient mice. J Immunol, 2015;194(12):5736-42. 2015 [PMID: 25948814] (IHC-P, Mouse)
• Brindle N, Joyce J, Rostker F, Lawlor E, Swigart-Brown L, Evan G, Hanahan D, Shchors K Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer. PLoS ONE, 2015;10(4):e0120348. 2015 [PMID: 25927437] (IHC, Mouse)
• Sharma S, Chintala N, Vadrevu S, Patel J, Karbowniczek M, Markiewski M Pulmonary alveolar macrophages contribute to the premetastatic niche by suppressing antitumor T cell responses in the lungs. J Immunol, 2015;194(11):5529-38. 2015 [PMID: 25911761] (Flow Cytometry, Mouse)
• Declercq, Annelies, Chiers, Koen, Van den Broeck, Wim, Dewulf, Jeroen, Eeckhaut, Venessa, Cornelissen, Maria, Bossier, Peter, Haesebrouck, Freddy, Decostere, Annemie Interactions of highly and low virulent Flavobacterium columnare isolates with gill tissue in carp and rainbow trout. Vet Res, 2015;46(0):25. 2015 [PMID: 25889257] (IHC-P, Fish - Cyprinus carpio (Carp))
• Sesen J, Dahan P, Scotland S, Saland E, Dang V, Lemarie A, Tyler B, Brem H, Toulas C, Cohen-Jonathan Moyal E, Sarry J, Skuli N Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response. PLoS ONE, 2015;10(4):e0123721. 2015 [PMID: 25867026] (IHC, Mouse)
• Scott C, Cha K, Rao R, Liddle C, George J, Gunton J Hepatocyte-specific deletion of ARNT (aryl hydrocarbon Receptor Nuclear Translocator) results in altered fibrotic gene expression in the thioacetamide model of liver injury. PLoS ONE, 2015;10(3):e0121650. 2015 [PMID: 25812120] (IHC-P, Mouse)
• Matsuda T, Murao N, Katano Y, Juliandi B, Kohyama J, Akira S, Kawai T, Nakashima K TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus. Nat Commun, 2015;6(0):6514. 2015 [PMID: 25751136] (ICC, Mouse)
• Luyet C, Schulze K, Sayar B, Howald D, Muller E, Galichet A Preclinical studies identify non-apoptotic low-level caspase-3 as therapeutic target in pemphigus vulgaris. PLoS ONE, 2015;10(3):e0119809. 2015 [PMID: 25748204] (ICC, Mouse)
• Sawhney S, Hood K, Shaw A, Braithwaite A, Stubbs R, Hung N, Royds J, Slatter T Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a 133p53alpha mimic. PLoS ONE, 2015;10(2):e0116270. 2015 [PMID: 25643152] (IHC-P, Mouse)
• Petersson, Monika, Reuter, Karen, Brylka, Heike, Kraus, Andreas, Schettina, Peter, Niemann, Catherin Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours. Nat Commun, 2015;6(0):5874. 2015 [PMID: 25608467] (IHC, Mouse)
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• Mracsko E, Liesz A, Stojanovic A, Lou W, Osswald M, Zhou W, Karcher S, Winkler F, Martin-Villalba A, Cerwenka A, Veltkamp R Antigen dependently activated cluster of differentiation 8-positive T cells cause perforin-mediated neurotoxicity in experimental stroke. J Neurosci, 2014;34(50):16784-95. 2014 [PMID: 25505331] (ICC, Mouse)
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• Siegl-Cachedenier I, Flores I, Klatt P, Blasco MA Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres. J. Cell Biol., 2007;179(2):277-90. 2007 [PMID: 17954610] (IHC-P, Mouse)
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Reviews for Caspase-3 Antibody (AF835) (7)

Average Rating: 4.9

(Based on 7 reviews)

We have 7 reviews tested in 2 species: Mouse, Other.

reviewed by: Anonymous WB Mouse 01/09/2015

Summary

• Application: Western Blot
• Sample Tested: See PMID 23374352
• Species: Mouse

Blocking

• Blocking Details: See PMID 23374352

Details

• Detection Notes: See PMID 23374352

Comments

• Comments: Published: See PMID 23374352Independent review from antibodyresource.com

reviewed by: Anonymous IHC-P Mouse 01/09/2015

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: See PMID 20522641
• Species: Mouse

reviewed by: Anonymous IHC-P Mouse 01/09/2015

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: See PMID 22897852
• Species: Mouse

reviewed by: Anonymous IHC-P Other 01/09/2015

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: See PMID 22438018
• Species: Other

reviewed by: Anonymous IF Mouse 01/09/2015

Summary

• Application: Immunofluorescence
• Sample Tested: See PMID 23532769
• Species: Mouse

Blocking

• Blocking Details: See PMID 23532769

Details

• Detection Notes: See PMID 23532769

Comments

• Comments: Published: See PMID 23532769Independent review from antibodyresource.com

reviewed by: Anonymous IF Mouse 01/09/2015

Summary

• Application: Immunofluorescence
• Sample Tested: See PMID 19226508
• Species: Mouse

Blocking

• Blocking Details: See PMID 19226508

Details

• Detection Notes: See PMID 19226508

Comments

• Comments: PublisheD: See PMID 19226508Independent review from antibodyresource.com

reviewed by: Anonymous IHC-P Mouse 01/09/2015

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: See PMID 23742999
• Species: Mouse

Bioinformatics

• Gene Symbol: CASP3
• Uniprot:
  • P42574()