Caspase-3 Antibody [Unconjugated] - Active

Caspase‑3 was detected in immersion fixed anti-FAS treated Jurkat human acute T cell leukemia cell line using 0.3 µg/mL Human/Mouse Active Caspase‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) for 3 hours at room temperature. Cells were stained (red) and counterstained (green). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Caspase-3 was detected in immersion fixed Jurkat human acute T cell leukemia cell line stimulated with staurosporin using Human/Mouse Active Caspase-3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Rabbit IgG Secondary Antibody (yellow; Catalog # NL004) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Caspase‑3 was detected in immersion fixed paraffin-embedded sections of human colon cancer tissue using Rabbit Anti-Human/Mouse Active Caspase‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) at 1 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Rabbit IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC003). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (//www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (//www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemical staining for caspase 3 on surgically transected tumours. A) Epo-treated tumour 24 hours after surgery. B) Placebo-treated tumour 24 hours after surgery. C) Placebo-treated tumour 48 hours after surgery Image collected and cropped by CiteAb from the following publication (//bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-648), licensed under a CC-BY license. Not internally tested by R&D Systems.

LPS challenge induces cell shedding from small intestinal villi. C57 BL/6 mice were administered either (a) PBS (control) or (b) LPS by IP injection and proximal small intestines removed after 1.5 h. Processed tissue was sectioned and stained by immunohistochemistry for CC3 (i.e. brown cells indicate shedding event), also highlighted by arrows. A representative picture for each group is shown (12 mice per group, two independent experiments). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28123052), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (//www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

The cytoprotective effect of B. breve is MyD88 dependent. (a,b) IEC MyD88+/+ mice and (c,d) IEC MyD88−/− mice were gavaged with PBS (control) or B. breve UCC2003 and challenged with LPS. Paraffin-embedded intestinal sections were stained with anti-CC3 and quantified using the WinCrypts and Score programs. (e) Columns shown TLR2 expression via RT-PCR. Data are mean ± s.d., n = 12 (two independent experiments) analysed with Mann–Whitney U-test. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28123052), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (//www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (//www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (//www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

Bifidobacterium breve UCC2003 protects against LPS-induced cell shedding. C57 BL/6 mice received three daily oral gavage doses of (a) PBS or (b) approximately 1 × 109B. breve UCC2003 followed by IP challenge with LPS 24 h later. Representative images are shown. Formalin-fixed, paraffin-embedded intestinal sections were sectioned and stained with anti-CC3 and (c) quantified using the WinCrypts and Score programs, 20 well-orientated hemi-villi were counted per mouse. Data are mean ± s.d., n = 12 (two independent experiments) analysed with a Mann–Whitney U-test. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28123052), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (//www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

Genetic deletion of Bax prevents mutant LRRK2 induced neuronal death. Primary embryonic cortical neurons are derived from WT mice or mice lacking the pro-apoptotic protein Bax, and transiently transfected with GFP-tagged WT or mutant LRRK2 (R1441C, G2019S). (a) A representative image showing typical morphological features of apoptotic neurons expressing mutant LRRK2; that are positive for active caspase-3 (casp3) and display condensed and fragmented nuclei. (b) Quantification of apoptotic neuronal death (apoptotic nuclear profiles, “apo”; and active caspase-3 positive neurons, “casp3”) from cultures depicted in (a); **p < 0.01 in comparison to WT transfected neurons. (c) Primary neurons were prepared from WT mice or mice deficient in Bax, and treated with the topoisomerase I inhibitor camptothecin (“cam”, 5 μM, 18 hr), or doxorubicin (“doxo”, 10 ng/ml, 36 hr). Cells were fixed and processed for apoptotic nuclear counts. (d) Primary cortical neurons were prepared from WT mice or mice deficient in Bax, and transiently transfected with WT, R1441C, or G2019S LRRK2. As before, the cultures were fixed and the percentage of LRRK2-positive neurons that displayed apoptotic nuclear features was determined. The absence of Bax significantly protected neurons from death induced by mutant LRRK2. ***p < 0.001 compared to WT neurons expressing R1441C- or G2019S-LRRK2. Each data point represents the mean +/− SEM from 3–4 independent transfections from a representative culture. Cultures were repeated at least 3 times with similar differences. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/29472595), licensed under a CC-BY license. Not internally tested by R&D Systems.

Hepatocyte ARNT deletion alters fibrotic and apoptotic gene expression in the TAA model of fibrosis.Results for FC are shown in black columns and LARNT in white columns. Results are expressed relative to FC level. (A) Messenger RNA expression of ARNT and collagen isotypes. (B) Expression of genes regulating fibrosis in FC and LARNT mice. (C) F4/80 and inflammatory cytokine expression in FC and LARNT mice. (D) Apoptotic gene expression in FC and LARNT mice. (E) Representative histology of FC liver stained with anti-Caspase 3 at 100X magnification. (F) Representative histology of LARNT liver stained with anti-Caspase 3 at 100X magnification. (G) Average Caspase 3 positive cell counts per field of view at 100 X magnification. Mean±SEM, * = p<0.05 ** = p<0.01, *** = p<0.001. N = 5-6/group. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0121650), licensed under a CC-BY license. Not internally tested by R&D Systems.

p140Cap expression is causative in limiting tumour growth in NeuT mice.(a) Expression cassette used for the generation of MMTV-p140Cap transgenic mice. The Myc epitope is inserted at the carboxyterminal region of the protein. (b) Extracts of tumours derived from NeuT mice (a,b) or p140-NeuT mice (c,d) were run on 6% SDS–PAGE and stained with antibodies to p140Cap, ERBB2 and tubulin for loading control. (c) Percentage of tumour free mice in NeuT (red line) and p140-NeuT (blue-dashed line) transgenic animals in both FVB (left) or BALB/c background (right). Twelve mice were analysed for each group. Fisher's exact test, Two sided, P=0,0022; P=0,0056. Error bar: s.e.m. (d) Total tumour burden in NeuT (red) and p140-NeuT (blue) mice in both the FVB (left) or BALB/c backgrounds (right) was measured. Ten mice were analysed in each group. Unpaired t test: (*P<0.05; ***P<0.001). Error bar: s.e.m. (e) Paraffin-embedded sections from three NeuT and three p140-NeuT tumours taken from mice at 33 weeks of age were analysed for hematoxylin–eosin (H&E) (a–d) and for immunohistochemistry with antibodies to NeuT (e–h), PCNA (i–l) and activated Caspase3 (m–p). Representative images are shown. Scale bar, 50 μm (first and third columns); 20μm (second and fourth columns). Histograms on the right show the percentage of PCNA+ (upper panel) and Activated Caspase3+ (lower panel) cells. Statistical significative differences were evaluated using unpaired t-tests (***P<0.001). Image collected and cropped by CiteAb from the following publication (//www.nature.com/articles/ncomms14797), licensed under a CC-BY license. Not internally tested by R&D Systems.

Microglia-derived TNF-alpha alleviates aberrant neurogenesis.(a) qRT-PCR analyses of Tnf-alpha levels in the DG of WT and TLR9 KO mice at the indicated time points after seizure. Experimental controls were KA-untreated WT and TLR9 KO mice, respectively (n=3 animals). *P<0.05 by analysis of variance (ANOVA) with Tukey post-hoc tests. (b) Experimental scheme for assessing aNS/PC proliferation in microglia culture-derived CM pretreated with TNF-alpha -neutralizing antibody or IgG control. (c) Representative images of EdU (red), active caspase3 (green) and Hoechst (blue) staining in aNS/PCs cultured with the indicated CM from microglia (n=4 experiments). Scale bar, 50 μm. (d) Quantification of EdU+ or active caspase3+ cells in c (n=4 experiments). (e) Experimental timeline for assessing aNS/PC proliferation in thalidomide (Thal)-treated mice. (f) Representative images of BrdU+DCX+ newly generated immature neurons in the DG (n=4 animals). Scale bar, 50 μm. (g,h) Quantification of the number of BrdU+DCX+ cells in f, in the DG (g) and in the hilus (h) (n=4 animals). *P<0.05 and **P<0.01 by ANOVA with Tukey post-hoc tests. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/25751136), licensed under a CC-BY license. Not internally tested by R&D Systems.

Double immunofluorescent staining of FSGS kidneys to Ki-67, alpha -tubulin and DAPI or double immunofluorescent staining to caspase-3 and DAPI. A. FSGS kidneys: cysts with simple squamous epithelium (CS) filled with colloid content, interstitium (i) and collecting tubules (ct) contain Ki-67-positive cells (arrows)(square). B. alpha -tubulin visualizes short cilia (arrows) in the cysts and extremely long cilia in collecting tubules (arrows)(square). C. Nuclear DAPI stain. D. Merging of A + B + C shows relationships between proliferating cells (green) and cilia (red). Immunostaining to Ki-67, alpha -tubulin and DAPI; scale bar 10 μm. E. Distribution of Ki-67 positive cells (%) in CNF and FSGS nephrotic syndrome. Cysts of proximal tubules with simple squamous epithelium (CS) or simple cuboidal epithelium (CC), proximal tubules with apparently normal simple cuboidal/columnar epithelium (PTNC). Data are shown as mean ± SD. Significant differences (Kruskal–Wallis) indicated by ***p < 0.0001. F. FSGS kidneys: caspase-3-positive apoptotic cells (arrows) in proximal tubules (PTNC) and interstitium (i). G. Nuclear DAPI stain. H. Merging of F + G shows green caspase-3- positive apoptotic nuclei and blue non-apoptotic nuclei. Immunostaining to caspase-3 and DAPI, scale bar 10 μm. Image collected and cropped by CiteAb from the following publication (//bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-15-3), licensed under a CC-BY license. Not internally tested by R&D Systems.

Epidermis-specific deletion of Rac1 increases UV-light-induced keratinocyte apoptosis in vivo. (a) H/E staining of UV-irradiated skin of Rac1 fl/fl and Rac1-EKO mice at 12 h after UV-irradiation. Black arrows indicate sunburn cells. (b) Graph shows the percentage number of sunburn cells at 12 h with (red bars) or without (blue bars) UV-irradiation in Rac1 fl/fl (n=4) and Rac1-EKO (n=5) mice. The percentage of sunburn cells within the epidermis after UV-irradiation in Rac1 fl/fl mice was 3.4%, whereas in Rac1-EKO mice it was 8.6% of total epidermal keratinocytes. Non-irradiated samples showed <1% sunburn cells in both the genotypes. (c) Immunostainings against cleaved caspase-3 (green) of UV-irradiated skin of Rac1 fl/fl and Rac1-EKO mice at 12 h after UV-irradiation. Nuclei are stained in blue. Scale bar=100 μm. (d) Western blot analysis of cleaved caspase-3 from epidermal lysates of untreated (no UV) and UV-light treated (UV) Rac1 fl/fl and Rac1-EKO mice. Non-irradiated controls showed no bands for cleaved capsase-3, whereas samples of irradiated epidermis showed cleaved caspase-3-specific bands at ~25 kDa and 23 kDa. Numbers on the left denote molecular weights in kDa. (e) Graph shows densitometry analysis of western blot in (d). Error bars show S.D. Asterisks show P-value<0.001 Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28277539), licensed under a CC-BY license. Not internally tested by R&D Systems.

Hepatocyte ARNT deletion alters fibrotic and apoptotic gene expression in the TAA model of fibrosis.Results for FC are shown in black columns and LARNT in white columns. Results are expressed relative to FC level. (A) Messenger RNA expression of ARNT and collagen isotypes. (B) Expression of genes regulating fibrosis in FC and LARNT mice. (C) F4/80 and inflammatory cytokine expression in FC and LARNT mice. (D) Apoptotic gene expression in FC and LARNT mice. (E) Representative histology of FC liver stained with anti-Caspase 3 at 100X magnification. (F) Representative histology of LARNT liver stained with anti-Caspase 3 at 100X magnification. (G) Average Caspase 3 positive cell counts per field of view at 100 X magnification. Mean±SEM, * = p<0.05 ** = p<0.01, *** = p<0.001. N = 5-6/group. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0121650), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemical staining for caspase 3 on surgically transected tumours. A) Epo-treated tumour 24 hours after surgery. B) Placebo-treated tumour 24 hours after surgery. C) Placebo-treated tumour 48 hours after surgery Image collected and cropped by CiteAb from the following publication (//bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-648), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (//www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

DNA damage has an important role in increased UV-light-induced keratinocyte apoptosis in Rac1-EKO epidermis in vivo. (a and c) H/E stainings and immunostainings against cleaved caspase-3 (green) of UV-irradiated skin of CPDPL/Rac1-EKO mice kept in the dark and under the photoreactivation lamp. Nuclei are stained in blue. Dashed line in c demarcates border between epidermis and dermis. Scale bar=100 μm. (e) Western blot analysis of cleaved caspase-3 from epidermal lysates of UV-irradiated CPDPL/Rac1-EKO mice kept in the dark and under the photoreactivation lamp. GAPDH was used as a loading control. Numbers on the left denote molecular weight in kDa. (b,d, and f) Graphs show quantification of sunburn cells (n=5, 4) (b), cleaved caspase-3 positive cells (n=9, 8) (d) and densitometric analysis of cleaved caspase-3 western blots (n=4, 6) (f) from UV-irradiated CPDPL/Rac1-EKO mice kept in the dark (black bars) and under the photoreactivation (PR) lamp (gray bars). Error bars show S.D. Asterisks show P-value. **<0.01, ***<0.001 Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28277539), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (//www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

DNA damage has an important role in increased UV-light-induced keratinocyte apoptosis in Rac1-EKO epidermis in vivo. (a and c) H/E stainings and immunostainings against cleaved caspase-3 (green) of UV-irradiated skin of CPDPL/Rac1-EKO mice kept in the dark and under the photoreactivation lamp. Nuclei are stained in blue. Dashed line in c demarcates border between epidermis and dermis. Scale bar=100 μm. (e) Western blot analysis of cleaved caspase-3 from epidermal lysates of UV-irradiated CPDPL/Rac1-EKO mice kept in the dark and under the photoreactivation lamp. GAPDH was used as a loading control. Numbers on the left denote molecular weight in kDa. (b,d, and f) Graphs show quantification of sunburn cells (n=5, 4) (b), cleaved caspase-3 positive cells (n=9, 8) (d) and densitometric analysis of cleaved caspase-3 western blots (n=4, 6) (f) from UV-irradiated CPDPL/Rac1-EKO mice kept in the dark (black bars) and under the photoreactivation (PR) lamp (gray bars). Error bars show S.D. Asterisks show P-value. **<0.01, ***<0.001 Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28277539), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (//www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemical staining for caspase 3 on surgically transected tumours. A) Epo-treated tumour 24 hours after surgery. B) Placebo-treated tumour 24 hours after surgery. C) Placebo-treated tumour 48 hours after surgery Image collected and cropped by CiteAb from the following publication (//bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-648), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (//www.mdpi.com/1422-0067/14/9/17729), licensed under a CC-BY license. Not internally tested by R&D Systems.

Smad1 deletion reduces oxidative stress and apoptosis following stroke.(A) Fluorescent images and quantification of in vivo HEt assay reflecting ROS levels on the ipsilateral hemisphere at 7 days post-stroke. The extent of oxidized nucleotides was measured by IHC for 8-oxo-dG levels at 24 h post-stroke. (B) IHC and quantification of activated Caspase 3 (aCasp3) and p53 on ipsilateral hemisphere at 7 days post-stroke. n = 3 for HEt, 8-oxo-dG, aCasp3, n = 4 for p53, unpaired Student’s t-test, *p<0.05; ***p<0.001. Scale, 50 μm. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0136967), licensed under a CC-BY license. Not internally tested by R&D Systems.

Effects of IGF-1 or/and PDGF-bb on IL-1 beta -induced NF-kappa B-dependent pro-inflammatory, pro-apoptotic and matrix degrading gene products in chondrocytes.To determine whether IGF-1 or/and PDGF-bbexert effects on IL-1 beta -induced NF-kappa B-dependent expression of pro-inflammatory, pro-apoptotic and matrix degrading gene products, primary chondrocytes were either stimulated with 10 ng/ml IL-1 beta , 10 ng/ml PDGF-bb, 10 ng/ml IGF-1 or combination of both growth factors (5 ng/ml each) or pre-stimulated for 12 h with 10 ng/ml PDGF-bb, 10 ng/ml IGF-1 or combination of both growth factors (5 ng/ml each) followed by 10 ng/ml IL-1 beta for 24. Equal amounts of total proteins were separated by SDS-PAGE and analyzed by immunoblotting using antibodies raised against COX-2, MMP-9 and MMP-13 and active caspase-3. Stimulation with IL-1 beta resulted in production of COX-2, MMP-9, MMP-13 and caspase-3 cleavage. Pre-treatment with a combination of both IGF-1 or/and PDGF-bb downregulated COX-2, MMP-9, MMP-13 and cleaved caspase-3. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0028663), licensed under a CC-BY license. Not internally tested by R&D Systems.

Double immunofluorescent staining of FSGS kidneys to Ki-67, alpha -tubulin and DAPI or double immunofluorescent staining to caspase-3 and DAPI. A. FSGS kidneys: cysts with simple squamous epithelium (CS) filled with colloid content, interstitium (i) and collecting tubules (ct) contain Ki-67-positive cells (arrows)(square). B. alpha -tubulin visualizes short cilia (arrows) in the cysts and extremely long cilia in collecting tubules (arrows)(square). C. Nuclear DAPI stain. D. Merging of A + B + C shows relationships between proliferating cells (green) and cilia (red). Immunostaining to Ki-67, alpha -tubulin and DAPI; scale bar 10 μm. E. Distribution of Ki-67 positive cells (%) in CNF and FSGS nephrotic syndrome. Cysts of proximal tubules with simple squamous epithelium (CS) or simple cuboidal epithelium (CC), proximal tubules with apparently normal simple cuboidal/columnar epithelium (PTNC). Data are shown as mean ± SD. Significant differences (Kruskal–Wallis) indicated by ***p < 0.0001. F. FSGS kidneys: caspase-3-positive apoptotic cells (arrows) in proximal tubules (PTNC) and interstitium (i). G. Nuclear DAPI stain. H. Merging of F + G shows green caspase-3- positive apoptotic nuclei and blue non-apoptotic nuclei. Immunostaining to caspase-3 and DAPI, scale bar 10 μm. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/24397250), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/23994836), licensed under a CC-BY license. Not internally tested by R&D Systems.

Representative sections of the medial side of right tibial epiphysis stained with/without caspase-3. Sections stained with caspase-3 antibody at four different time points (DH: A, C, E and G; BS2: B, D, F and H); a higher magnification (I); the growth plate (J) and fibrocartilage of anterior cruciate ligament (K) show caspase-3 positive cells (red cytoplasmic staining; arrow). A negative control section is shown in (L). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/23994836), licensed under a CC-BY license. Not internally tested by R&D Systems.

Effects of IGF-1 or/and PDGF-bb on IL-1 beta -induced NF-kappa B-dependent pro-inflammatory, pro-apoptotic and matrix degrading gene products in chondrocytes.To determine whether IGF-1 or/and PDGF-bbexert effects on IL-1 beta -induced NF-kappa B-dependent expression of pro-inflammatory, pro-apoptotic and matrix degrading gene products, primary chondrocytes were either stimulated with 10 ng/ml IL-1 beta , 10 ng/ml PDGF-bb, 10 ng/ml IGF-1 or combination of both growth factors (5 ng/ml each) or pre-stimulated for 12 h with 10 ng/ml PDGF-bb, 10 ng/ml IGF-1 or combination of both growth factors (5 ng/ml each) followed by 10 ng/ml IL-1 beta for 24. Equal amounts of total proteins were separated by SDS-PAGE and analyzed by immunoblotting using antibodies raised against COX-2, MMP-9 and MMP-13 and active caspase-3. Stimulation with IL-1 beta resulted in production of COX-2, MMP-9, MMP-13 and caspase-3 cleavage. Pre-treatment with a combination of both IGF-1 or/and PDGF-bb downregulated COX-2, MMP-9, MMP-13 and cleaved caspase-3. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/22194879), licensed under a CC-BY license. Not internally tested by R&D Systems.

Allelic loss of Cdh11 led to faster growing tumors due to decreased cell death. (E) Cadherin-11 was knocked down using stealth siRNA in a cadherin-11 expressing cell line derived from TAg-RB tumors, T +539. Knockdown of Cdh11 clearly decreased caspase-3 expression compared to control. Image collected & cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/20421947), licensed under a CC-BY license. Not internally tested by R&D Systems.

Curcumin inhibits IL-1 beta activity, enabling co-culture induced chondrogenesis in MSCs. A: Fourteen days high-density culture. Untreated MSC cultures became apoptotic (a). In primary chondrocyte cultures (b), co-cultures (c), co-cultures treated with curcumin (e) or co-cultures pre-stimulated four hours with curcumin (f), prominent chondrogenesis was observed. Stimulation of the co-culture with IL-1 beta alone resulted in degeneration of the cell culture (d). In contrast, a four-hour pre-stimulation of the co-culture with curcumin followed by IL-1 beta incubation (g) or a four-hour pre-stimulation of the co-culture with curcumin followed by IL-1 beta and curcumin incubation (h) inhibited the adverse effects of IL-1 beta on the chondrogenic potential of the co-culture and prominent chondrogenesis was observed. Magnification, 6,000×; bar, 1 μm; C, chondrocytes, F, fibroblast-like cells; M, ECM. B-D: Immunoblots of whole cell lysates were probed with antibodies against CSPGs, collagen type II, beta 1-integrin, Shc, activated-ERK1/2, Sox-9, activated-caspase-3 and COX-2. In co-cultures pre-stimulated for four hours with curcumin followed either by incubation with IL-1 beta alone or incubation with IL-1 beta and curcumin, prominent production of chondrogenic matrix and adhesion molecules (B), activation of the chondrogenic signalling pathway (C) and down-regulation of apoptotic and inflammatory markers (D) was observed. Each experiment was performed in triplicate. Expression of the housekeeping gene beta -actin was not affected. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/20594343), licensed under a CC-BY license. Not internally tested by R&D Systems.

• Reactivity: Hu, Mu
• Applications: IHC, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: LYOPH

Caspase-3 Antibody [Unconjugated] - Active Summary

• Immunogen: KLH-coupled human Caspase-3 synthetic peptide
  CRGTELDCGIETD
  Accession # P42574
• Specificity: Distinguishes apoptotic cells from non-apoptotic cells in immunohistochemistry. Detects the p17 subunit of Caspase-3, but does not detect the precursor form in Western blot. We recommend R&D Systems Affinity Purified Anti-Caspase-3 (Catalog # AF-605-NA) or Monoclonal Anti-Cleaved-Caspase-3 (Catalog # MAB835) for Western blot applications.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CASP3
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry 5-15 ug/mL
  • Immunohistochemistry 1-15 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Caspase-3 Antibody [Unconjugated] - Active

• Apopain
• apoptosis-related cysteine protease
• CASP3
• CASP-3
• caspase 3, apoptosis-related cysteine peptidase
• Caspase3
• Caspase-3
• CPP32
• CPP-32
• CPP32B
• CPP32SREBP cleavage activity 1
• Cysteine protease CPP32
• EC 3.4.22
• EC 3.4.22.56
• LICE-1
• PARP cleavage protease
• procaspase3
• Protein Yama
• SCA-1
• YAMA

Background

Caspase-3 (Cysteine-aspartic acid protease 3/Casp3; also Yama, apopain and CPP32) is a 29 kDa heterodimer that belongs to the peptidase C14A family of enzymes. It is widely expressed, and considered to be the major executioner caspase in the apoptotic cascade. Human procaspase-3 is a 32 kDa, 277 amino acid (aa) protein and is normally an inactive homodimer. Following cell stress/activation, procaspase-3 undergoes proteolysis to generate an N-terminal 148 aa p17/17 kDa subunit (aa 29-175), plus a 102 aa C-terminal p12/12 kDa subunit. These subunits noncovalently heterodimerize, and associate with another p17/p12 heterodimer to form an active enzyme. There is one potential variant that shows an alternative start site nine aa upstream of the standard start site coupled with a 21 aa substitution for aa 162-277. Over aa 29-175, human and mouse caspase-3 share 87% aa identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Caspase-3 Antibody (AF835)(423)

Publications using AF835

• Duncan, GJ;Ingram, SD;Emberley, K;Hill, J;Cordano, C;Abdelhak, A;McCane, M;Jenks, JE;Jabassini, N;Ananth, K;Ferrara, SJ;Stedelin, B;Sivyer, B;Aicher, SA;Scanlan, TS;Watkins, TA;Mishra, A;Nelson, JW;Green, AJ;Emery, B; Remyelination protects neurons from DLK-mediated neurodegeneration. Nature communications 2024-10-23 [PMID: 39443516] (Immunohistochemistry, Mouse)
• Soliman, E;Gudenschwager Basso, EK;Ju, J;Willison, A;Theus, MH; Skull bone marrow-derived immune cells infiltrate the injured cerebral cortex and exhibit anti-inflammatory properties Brain, behavior, and immunity 2024-09-16 [PMID: 39293691] (Immunohistochemistry, Transgenic Mouse)
• Despin-Guitard, E;Rosa, VS;Plunder, S;Mathiah, N;Van Schoor, K;Nehme, E;Merino-Aceituno, S;Egea, J;Shahbazi, MN;Theveneau, E;Migeotte, I; Non-apical mitoses contribute to cell delamination during mouse gastrulation Nature communications 2024-08-28 [PMID: 39198421] (Immunohistochemistry, Mouse)
• Sim, JH;Bell, R;Feng, Z;Chyou, S;Shipman, WD;Kataru, RP;Ivashkiv, L;Mehrara, B;Lu, TT; Langerhans cells regulate immunity in adulthood by regulating postnatal dermal lymphatic development bioRxiv : the preprint server for biology 2024-07-16 [PMID: 39071369] (Immunohistochemistry, Mouse, Transgenic Mouse)
• Gauberg, J;Moreno, KB;Jayaraman, K;Abumeri, S;Jenkins, S;Salazar, AM;Meharena, HS;Glasgow, SM; Spinal motor neuron development and metabolism are transcriptionally regulated by Nuclear Factor IA bioRxiv : the preprint server for biology 2024-06-26 [PMID: 38979382] (Immunohistochemistry, Transgenic Mouse)
• Köhne, M;Diel, E;Packeiser, EM;Böttcher, D;Tönissen, A;Unruh, C;Goericke-Pesch, S;Ulrich, R;Sieme, H; Analysis of gene and protein expression in the endometrium for validation of an ex vivo model of the equine uterus using PCR, digital and visual histopathology Theriogenology 2024-03-25 [PMID: 38537320] (Immunohistochemistry, Equine)
• Merkuri, F;Rothstein, M;Simoes-Costa, M; Histone lactylation couples cellular metabolism with developmental gene regulatory networks Nature communications 2024-01-02 [PMID: 38167340] (IHC, Chicken)
• Zhao, S;Mekbib, KY;van der Ent, MA;Allington, G;Prendergast, A;Chau, JE;Smith, H;Shohfi, J;Ocken, J;Duran, D;Furey, CG;Hao, LT;Duy, PQ;Reeves, BC;Zhang, J;Nelson-Williams, C;Chen, D;Li, B;Nottoli, T;Bai, S;Rolle, M;Zeng, X;Dong, W;Fu, PY;Wang, YC;Mane, S;Piwowarczyk, P;Fehnel, KP;See, AP;Iskandar, BJ;Aagaard-Kienitz, B;Moyer, QJ;Dennis, E;Kiziltug, E;Kundishora, AJ;DeSpenza, T;Greenberg, ABW;Kidanemariam, SM;Hale, AT;Johnston, JM;Jackson, EM;Storm, PB;Lang, SS;Butler, WE;Carter, BS;Chapman, P;Stapleton, CJ;Patel, AB;Rodesch, G;Smajda, S;Berenstein, A;Barak, T;Erson-Omay, EZ;Zhao, H;Moreno-De-Luca, A;Proctor, MR;Smith, ER;Orbach, DB;Alper, SL;Nicoli, S;Boggon, TJ;Lifton, RP;Gunel, M;King, PD;Jin, SC;Kahle, KT; Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations Nature communications 2023-11-17 [PMID: 37978175] (IHC, Transgenic Mouse)
• Meah, A;Vedarethinam, V;Bronstein, R;Gujarati, N;Jain, T;Mallipattu, SK;Li, Y;Wang, J; Single-Cell Spatial MIST for Versatile, Scalable Detection of Protein Markers Biosensors 2023-08-27 [PMID: 37754086] (IHC, Mouse)
• Le, CT;Vick, LV;Collins, C;Dunai, C;Sheng, MK;Khuat, LT;Barao, I;Judge, SJ;Aguilar, EG;Curti, B;Dave, M;Longo, DL;Blazar, BR;Canter, RJ;Monjazeb, AM;Murphy, WJ; Regulation of human and mouse bystander T cell activation responses by PD-1 JCI insight 2023-09-22 [PMID: 37737264] (IHC, Mouse)
• Subramanian Dharmarajan, Casandra Carrillo, Zhonghua Qi, Jonathan M. Wilson, Anthony J. Baucum, Christine M. Sorenson et al. Retinal inflammation in murine models of type 1 and type 2 diabetes with diabetic retinopathy Diabetologia 9/5/2023 [PMID: 37670018]
• Taylor Hinnant, Wenxiu Ning, Terry Lechler Compartment specific responses to contractility in the small intestinal epithelium bioRxiv 8/11/2023 [PMID: 37609300]
• Brockmueller, A;Girisa, S;Motallebi, M;Kunnumakkara, AB;Shakibaei, M; Calebin A targets the HIF-1?/NF-?B pathway to suppress colorectal cancer cell migration Frontiers in pharmacology 2023-07-31 [PMID: 37583906] (Western Blot, Human)
• Aranka Brockmueller, Constanze Buhrmann, Parviz Shayan, Mehdi Shakibaei Resveratrol induces apoptosis by modulating the reciprocal crosstalk between p53 and Sirt-1 in the CRC tumor microenvironment Frontiers in Immunology 7/27/2023 [PMID: 37575245]
• Sinclair-Wilson, A;Lawrence, A;Ferezou, I;Cartonnet, H;Mailhes, C;Garel, S;Lokmane, L; Plasticity of thalamocortical axons is regulated by serotonin levels modulated by preterm birth Proceedings of the National Academy of Sciences of the United States of America 2023-08-15 [PMID: 37549297] (IHC, Mouse)
• Wang, D;Li, H;Chandel, NS;Dou, Y;Yi, R; MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters Nature communications 2023-07-21 [PMID: 37479688] (IHC, Mouse)
• Del Monte-Monge, A;Ruiz-Polo de Lara, Í;Gonzalo, P;Espinós-Estévez, C;González-Amor, M;de la Fuente-Pérez, M;Andrés-Manzano, MJ;Fanjul, V;Gimeno, JR;Barriales-Villa, R;Dorado, B;Andrés, V; Lamin A/C Ablation Restricted to Vascular Smooth Muscle Cells, Cardiomyocytes, and Cardiac Fibroblasts Causes Cardiac and Vascular Dysfunction International journal of molecular sciences 7/6/2023 [PMID: 37446344]
• Wei, H;Du, S;Parksong, J;Pasolli, HA;Matte-Martone, C;Regot, S;Gonzalez, LE;Xin, T;Greco, V; Organ function is preserved despite reorganization of niche architecture in the hair follicle Cell stem cell 2023-07-06 [PMID: 37419106] (IHC, Mouse)
• Rivera Alvarez, J;Asselin, L;Tilly, P;Benoit, R;Batisse, C;Richert, L;Batisse, J;Morlet, B;Levet, F;Schwaller, N;Mély, Y;Ruff, M;Reymann, AC;Godin, JD; The kinesin Kif21b regulates radial migration of cortical projection neurons through a non-canonical function on actin cytoskeleton Cell reports 2023-07-06 [PMID: 37418324] (IHC, Mouse)
• Gallini, S;Annusver, K;Rahman, NT;Gonzalez, DG;Yun, S;Matte-Martone, C;Xin, T;Lathrop, E;Suozzi, KC;Kasper, M;Greco, V; Injury prevents Ras mutant cell expansion in mosaic skin Nature 2023-06-21 [PMID: 37344586] (IHC, Mouse)
• Congiu, L;Granato, V;Jakovcevski, I;Kleene, R;Fernandes, L;Freitag, S;Kneussel, M;Schachner, M;Loers, G; Mice Mutated in the Third Fibronectin Domain of L1 Show Enhanced Hippocampal Neuronal Cell Death, Astrogliosis and Alterations in Behavior Biomolecules 2023-04-29 [PMID: 37238646] (IHC, Mouse)
• Kelly, SB;Dean, JM;Zahra, VA;Dudink, I;Thiel, A;Polglase, GR;Miller, SL;Hooper, SB;Bennet, L;Gunn, AJ;Galinsky, R; Progressive inflammation reduces high-frequency EEG activity and cortical dendritic arborisation in late gestation fetal sheep Journal of neuroinflammation 2023-05-24 [PMID: 37226206] (IHC, Ovine)
• Rafael Soares Godoy, Nicholas D Cober, David P Cook, Emma McCourt, Yupu Deng, Liyuan Wang et al. Single-cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation eLife 4/20/2023 [PMID: 37078698]
• Conley MJ, Epifano I, Kirk A et al. Microwave hyperthermia represses human papillomavirus oncoprotein activity and induces cell death due to cell stress in 3D tissue models of anogenital precancers and cancers EBioMedicine 4/15/2023 [PMID: 37068348]
• Debaugnies M, Rodr�guez-Acebes S, Blondeau J et al. RHOJ controls EMT-associated resistance to chemotherapy Nature 3/22/2023 [PMID: 36949199]
  
  Details:
  Dilution used in ICC/IF 1:200
• A Brockmuell, S Girisa, AB Kunnumakka, M Shakibaei Resveratrol Modulates Chemosensitisation to 5-FU via beta1-Integrin/HIF-1alpha Axis in CRC Tumor Microenvironment International Journal of Molecular Sciences, 2023-03-05;24(5):. 3/5/2023 [PMID: 36902421]
• L Provitera, A Tomaselli, G Raffaeli, S Crippa, C Arribas, I Amodeo, S Gulden, GS Amelio, V Cortesi, F Manzoni, G Cervellini, J Cerasani, C Menis, N Pesenti, M Tripodi, L Santi, M Maggioni, C Lonati, S Oldoni, F Algieri, F Garrido, ME Bernardo, F Mosca, G Cavallaro Human Bone Marrow-Derived Mesenchymal Stromal Cells Reduce the Severity of Experimental Necrotizing Enterocolitis in a Concentration-Dependent Manner Cells, 2023-02-27;12(5):. 2023-02-27 [PMID: 36899900] (IHC, Mouse)
• Julia Elrod, Moritz Lenz, Antonia Kiwit, Lina Armbrust, Lavinia Schönfeld, Konrad Reinshagen et al. Murine scald models characterize the role of neutrophils and neutrophil extracellular traps in severe burns Frontiers in Immunology 2/7/2023 [PMID: 36825027]
• P Martino, R Sunkara, N Heitman, M Rangl, A Brown, N Saxena, L Grisanti, D Kohan, M Yanagisawa, M Rendl Progenitor-derived endothelin controls dermal sheath contraction for hair follicle regression Nature Cell Biology, 2023-01-30;0(0):. 2023-01-30 [PMID: 36717629] (IHC, Mouse)
• D Piekna-Prz, D Na, J Zhang, C Baker, JM Ashton, PM White Single cell RNA sequencing analysis of mouse cochlear supporting cell transcriptomes with activated ERBB2 receptor indicates a cell-specific response that promotes CD44 activation Frontiers in Cellular Neuroscience, 2023-01-06;16(0):1096872. 2023-01-06 [PMID: 36687526] (ICC, Mouse)
• Tang X, Wei W, Snowball JM et al. EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly iScience 11/1/2022 [PMID: 36624844]
• Maryann P. Platt, Yi-Han Lin, Trevor Penix, Rosana Wiscovitch-Russo, Isha Vashee, Chris A. Mares et al. A multiomics analysis of direct interkingdom dynamics between influenza A virus and Streptococcus pneumoniae uncovers host-independent changes to bacterial virulence fitness PLOS Pathogens 12/21/2022 [PMID: 36542660]
• G Ortiz-Álva, A Fortoul, A Srivastava, MX Moreau, B Bouloudi, C Mailhes-Ha, N Delgehyr, M Faucourt, M Bahin, C Blugeon, M Breau, V Géli, F Causeret, A Meunier, N Spassky p53/p21 pathway activation contributes to the ependymal fate decision downstream of GemC1 Cell Reports, 2022-12-13;41(11):111810. 2022-12-13 [PMID: 36516767] (IHC, Mouse)
• Michael L. Piacentino, Erica J. Hutchins, Cecelia J. Andrews, Marianne E. Bronner Temporal changes in plasma membrane lipid content induce endocytosis to regulate developmental epithelial-to-mesenchymal transition Proceedings of the National Academy of Sciences 12/20/2022 [PMID: 36508654]
• SS Karshieva, EG Glinskaya, AA Dalina, EV Akhlyustin, EA Makarova, YD Khesuani, NS Chmelyuk, MA Abakumov, DA Khochenkov, VA Mironov, GA Meerovich, EA Kogan, EV Koudan Antitumor activity of photodynamic therapy with tetracationic derivative of synthetic bacteriochlorin in spheroid culture of liver and colon cancer cells Photodiagnosis and photodynamic therapy, 2022-11-15;0(0):103202. 2022-11-15 [PMID: 36400167] (IHC, Human)
• Roxane Van Heurck, Jérôme Bonnefont, Marta Wojno, Ikuo K. Suzuki, Fausto D. Velez-Bravo, Emir Erkol et al. CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors Neuron 1/4/2023 [PMID: 36334595]
• A Brockmuell, AL Mueller, P Shayan, M Shakibaei beta1-Integrin plays a major role in resveratrol-mediated anti-invasion effects in the CRC microenvironment Frontiers in Pharmacology, 2022-09-02;13(0):978625. 9/2/2022 [PMID: 36120305]
• W Wei, X Tang, N Jiang, C Ni, H He, S Sun, M Yu, C Yu, M Qiu, D Yan, Z Zhou, Y Song, H Liu, B Zhao, X Lin Chromatin Remodeler Znhit1 Controls Bone Morphogenetic Protein Signaling in Embryonic Lung Tissue Branching The Journal of Biological Chemistry, 2022-09-14;0(0):102490. 9/14/2022 [PMID: 36115458]
• Jeong-Ki Park, Min-Jae Yoo, Hyuk Jang, Sang-Youel Park, Jawun Choi, Jae-Won Seol Methyl Gallate Suppresses Tumor Development by Increasing Activation of Caspase3 and Disrupting Tumor Angiogenesis in Melanoma Evidence-Based Complementary and Alternative Medicine 9/6/2022 [PMID: 36110191]
• M García-Pug, A Saenz-Anto, G Gerenu, A Arrieta, R Fernandez-, M Zulaica, A Saenz, J Elizazu, G Nogales-Ga, SM Gadalla, MJ Araúzo-Bra, A Lopez de M, A Matheu Senescence plays a role in Myotonic Dystrophy type 1 JCI Insight, 2022-10-10;0(0):. 2022-10-10 [PMID: 36040809] (Flow Cytometry, Mouse)
• Thale Kristin Olsen, Cecilia Dyberg, Bethel Tesfai Embaie, Adele Alchahin, Jelena Milosevic, Jane Ding et al. DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma JCI Insight 9/8/2022 [PMID: 35943801]
• EG Vasquez, N Nasreddin, GN Valbuena, EJ Mulholland, HL Belnoue-Da, HR Eggington, RO Schenck, VM Wouters, P Wirapati, K Gilroy, TRM Lannagan, DJ Flanagan, AK Najumudeen, S Omwenga, AMB McCorry, A Easton, VH Koelzer, JE East, D Morton, L Trusolino, T Maughan, AD Campbell, MB Loughrey, PD Dunne, P Tsantoulis, DJ Huels, S Tejpar, OJ Sansom, SJ Leedham Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia Cell Stem Cell, 2022-08-04;29(8):1213-1228.e8. 2022-08-04 [PMID: 35931031] (IHC, Mouse)
• Stamatia Papoutsopoulou, Joseph Tang, Ahmed H. Elramli, Jonathan M. Williams, Nitika Gupta, Felix I. Ikuomola et al. Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa American Journal of Physiology-Gastrointestinal and Liver Physiology 10/1/2022 [PMID: 35916405]
• T Imai, TM Van, M Pasparakis, A Polykratis Smooth muscle cell specific NEMO deficiency inhibits atherosclerosis in ApoE-/- mice Scientific Reports, 2022-07-22;12(1):12538. 2022-07-22 [PMID: 35869246] (IHC, Mouse)
• Rolando S. Matos, Davide Maselli, John H. McVey, Christian Heiss, Paola Campagnolo 3D Printed Bioreactor Enabling the Pulsatile Culture of Native and Angioplastied Large Arteries Frontiers in Cardiovascular Medicine 6/21/2022 [PMID: 35800166]
• AE Hall, SÖ Pohl, P Cammareri, S Aitken, NT Younger, M Raponi, CV Billard, AB Carrancio, A Bastem, P Freile, F Haward, IR Adams, JF Caceres, P Preyzner, A von Kriegs, MG Dunlop, FV Din, KB Myant RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer Nature Communications, 2022-05-19;13(1):2791. 2022-05-19 [PMID: 35589755] (IHC, Mouse)
• RJ Krawetz, YE Wu, KL Bertram, A Shonak, AO Masson, G Ren, C Leonard, M Kapoor, JR Matyas, PT Salo Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity Cell Death & Disease, 2022-05-18;13(5):470. 2022-05-18 [PMID: 35585042] (IHC, Human, Mouse)
• R Belgacemi, S Danopoulos, G Deutsch, I Glass, V Dormoy, S Bellusci, D Al Alam Hedgehog Signaling Pathway Orchestrates Human Lung Branching Morphogenesis International Journal of Molecular Sciences, 2022-05-09;23(9):. 2022-05-09 [PMID: 35563656] (IHC, Human)
• Aranka Brockmueller, Parviz Shayan, Mehdi Shakibaei Evidence That beta 1-Integrin Is Required for the Anti-Viability and Anti-Proliferative Effect of Resveratrol in CRC Cells International Journal of Molecular Sciences 4/25/2022 [PMID: 35563105]
• P Yamkate, JA Lidbury, JM Steiner, JS Suchodolsk, PR Giaretta Immunohistochemical Expression of Oxidative Stress and Apoptosis Markers in Archived Liver Specimens from Dogs with Chronic Hepatitis Journal of comparative pathology, 2022-04-01;193(0):25-36. 2022-04-01 [PMID: 35487620] (IHC, Canine)
• Olivia J. Marola, Gareth R. Howell, Richard T. Libby Vascular derived endothelin receptor A controls endothelin-induced retinal ganglion cell death Cell Death Discovery 4/16/2022 [PMID: 35429992]
• Olivia J. Marola, Gareth R. Howell, Richard T. Libby Vascular derived endothelin receptor A controls endothelin-induced retinal ganglion cell death Cell Death Discovery 2022-04-16 [PMID: 35429992] (Immunohistochemistry, Transgenic Mouse)
• H Wen, X Zhang, Q Li, J Huang, G Liu, J Zhao, Y Liu, L Shen, Y Li, K Yang, L Zuo, J Li, J Nian, P Xiang, H Zhao, L Yu, M Liu, Z Geng, X Song Ruscogenins Improve CD-Like Enteritis by Inhibiting Apoptosis of Intestinal Epithelial Cells and Activating Nrf2/NQO1 Pathway Oxidative Medicine and Cellular Longevity, 2022-03-10;2022(0):4877275. 2022-03-10 [PMID: 35308175] (ICC/IF, Mouse)
• Amanda Almacellas-Barbanoj, Martina Albini, Annyesha Satapathy, Fanny Jaudon, Caterina Michetti, Alicja Krawczun-Rygmaczewska et al. Kidins220/ARMS modulates brain morphology and anxiety-like traits in adult mice Cell Death Discovery 2/9/2022 [PMID: 35140204]
• Daniel S. Simpson, Jiyi Pang, Ashley Weir, Isabella Y. Kong, Melanie Fritsch, Maryam Rashidi et al. Interferon-gamma primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway Immunity 3/1/2022 [PMID: 35139355]
• Jaione Auzmendi-Iriarte, Maddalen Otaegi-Ugartemendia, Estefania Carrasco-Garcia, Mikel Azkargorta, Antonio Diaz, Ander Saenz-Antoñanzas et al. Chaperone-Mediated Autophagy Controls Proteomic and Transcriptomic Pathways to Maintain Glioma Stem Cell Activity Cancer Research 4/1/2022 [PMID: 35131870]
• Chunxing Yang, Tao Qiao, Jia Yu, Hongyan Wang, Yansu Guo, Johnny Salameh et al. Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice PLOS ONE 2/3/2022 [PMID: 35113871]
• C Lee, J Kim, J Han, D Oh, M Kim, H Jeong, TJ Kim, SW Kim, JN Kim, YS Seo, A Suzuki, JH Kim, Y Jung Formyl peptide receptor 2 determines sex-specific differences in the progression of nonalcoholic fatty liver disease and steatohepatitis Nature Communications, 2022-01-31;13(1):578. 2022-01-31 [PMID: 35102146] (IHC, Mouse)
• S André, M Picard, R Cezar, F Roux-Dalva, A Alleaume-B, C Soundaramo, AS Cruz, A Mendes-Fri, C Gotti, M Leclercq, A Nicolas, A Tauzin, A Carvalho, C Capela, J Pedrosa, AG Castro, L Kundura, P Loubet, A Sotto, L Muller, JY Lefrant, C Roger, PG Claret, S Duvnjak, TA Tran, G Racine, O Zghidi-Abo, P Nioche, R Silvestre, A Droit, F Mammano, P Corbeau, J Estaquier T cell apoptosis characterizes severe Covid-19 disease Cell Death and Differentiation, 2022-01-22;0(0):. 2022-01-22 [PMID: 35066575] (ICC, Human)
• D Chen, ED Hughes, TL Saunders, J Wu, MN Hernández, T Makinen, PD King Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells JCI Insight, 2022-02-22;0(0):. 2022-02-22 [PMID: 35015735] (IHC, Mouse)
• J Schreiber, N Liaukouska, L Fuhrmann, AT Hauser, M Jung, TB Huber, N Wanner BET Proteins Regulate Expression of Osr1 in Early Kidney Development Biomedicines, 2021-12-10;9(12):. 2021-12-10 [PMID: 34944697] (ICC, Mouse)
• P Flora, MY Li, PM Galbo, M Astorkia, D Zheng, E Ezhkova Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration PloS Genetics, 2021-12-14;17(12):e1009948. 2021-12-14 [PMID: 34905545] (IHC, Transgenic Mouse)
• B Schwarze, A Korn, C Höfling, U Zeitschel, M Krueger, S Ro beta ner, D Huster Peptide backbone modifications of amyloid beta (1-40) impact fibrillation behavior and neuronal toxicity Scientific Reports, 2021-12-09;11(1):23767. 2021-12-09 [PMID: 34887476] (ICC, Mouse)
• David Sokolov, Emily R Sechrest, Yekai Wang, Connor Nevin, Jianhai Du, Saravanan Kolandaivelu Nuclear NAD+-biosynthetic enzyme NMNAT1 facilitates development and early survival of retinal neurons eLife 12/8/2021 [PMID: 34878972]
• Paschalis Theotokis, Evangelia Kesidou, Dimitra Mitsiadou, Steven Petratos, Olympia Damianidou, Marina Boziki et al. Lumbar spine intrathecal transplantation of neural precursor cells promotes oligodendrocyte proliferation in hot spots of chronic demyelination Brain Pathology 7/1/2022 [PMID: 34845781]
• W Nakajima, S Nakanishi, R Hosoya, T Uemoto, S Ohgo, N Wada Regenerative Polarity of the Fin Ray in Zebrafish Caudal Fin and Related Tissue Formation on the Cut Surface Journal of developmental biology, 2021-11-19;9(4):. 2021-11-19 [PMID: 34842743] (IHC, Zebrafish)
• Tiziana Napolitano, Fabio Avolio, Serena Silvano, Sara Forcisi, Anja Pfeifer, Andhira Vieira et al. Gfi1 Loss Protects against Two Models of Induced Diabetes Cells 10/20/2021 [PMID: 34831029]
• M Dottermusc, P Sumis?awsk, J Krevet, M Middelkamp, H Vo beta , B Siebels, H Bartsch, K Sotlar, P Meyer, S Frank, A Korshunov, M Glatzel, U Schüller, JE Neumann Co-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma Oncogenesis, 2021-11-16;10(11):78. 2021-11-16 [PMID: 34785636] (IHC, Mouse)
• Yana Liu, Shihong Zhang, Zhiwei Xue, Xiaoxia Zhou, Lin Tong, Jiachen Liao et al. Bone mesenchymal stem cells-derived miR-223-3p-containing exosomes ameliorate lipopolysaccharide-induced acute uterine injury via interacting with endothelial progenitor cells Bioengineered 12/20/2021 [PMID: 34738867]
• S Shi, MMA Verstegen, HP Roest, AI Ardisasmit, W Cao, FJM Roos, PE de Ruiter, M Niemeijer, Q Pan, JNM IJzermans, LJW van der La Recapitulating cholangiopathy-associated necroptotic cell death in vitro using human cholangiocyte organoids Cellular and Molecular Gastroenterology and Hepatology, 2021-10-23;0(0):. 2021-10-23 [PMID: 34700031] (IF, Human)
• C Junqueira, R Dariolli, J Haydak, S Kang, T Hannah, RJ Wiener, S DeFronzo, R Tejero, GL Gusella, A Ramakrishn, R Alves Dias, A Wojcinski, S Kesari, L Shen, EA Sobie, JP Rodrigues, EU Azeloglu, H Zou, RH Friedel Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion Nature Communications, 2021-10-14;12(1):6019. 2021-10-14 [PMID: 34650052] (ICC, Human)
• EJ Ruiz, A Pinto-Fern, AP Turnbull, L Lan, TM Charlton, HC Scott, A Damianou, G Vere, EM Riising, C Da Costa, WW Krajewski, D Guerin, JD Kearns, S Ioannidis, M Katz, C McKinnon, J O'Connell, N Moncaut, I Rosewell, E Nye, N Jones, C Heride, M Gersch, M Wu, CJ Dinsmore, TR Hammonds, S Kim, D Komander, S Urbe, MJ Clague, BM Kessler, A Behrens USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma Elife, 2021-10-12;10(0):. 2021-10-12 [PMID: 34636321] (IHC, Mouse)
• F Harnischfe, F O'Connell, M Weiss, B Axelrod, A Hajnal, K Czaja, PM Di Lorenzo, R Dando Sprague Dawley Rats Gaining Weight on a High Energy Diet Exhibit Damage to Taste Tissue Even after Return to a Healthy Diet Nutrients, 2021-08-31;13(9):. 2021-08-31 [PMID: 34578940] (IHC, Rat)
• Li MY, Flora P, Pu H Et al. UV-induced reduction in Polycomb repression promotes epidermal pigmentation Developmental cell 8/30/2021 [PMID: 34473941]
• A Soni, D Klütsch, X Hu, J Houtman, N Rund, A McCloskey, J Mertens, ST Schafer, H Amin, T Toda Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells Cells, 2021-07-26;10(8):. 2021-07-26 [PMID: 34440662] (ICC, Mouse)
• N Mary, A Calgaro, H Barasc, N Bonnet, S Ferchaud, I Raymond-Le, A Ducos, A Pinton Meiotic Silencing in Pigs: A Case Study in a Translocated Azoospermic Boar Genes, 2021-07-27;12(8):. 2021-07-27 [PMID: 34440311] (IHC, Porcine)
• HM Schmitt, RL Fehrman, ME Maes, H Yang, LW Guo, CL Schlamp, HR Pelzel, RW Nickells Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression Investigative Ophthalmology & Visual Science, 2021-08-02;62(10):14. 2021-08-02 [PMID: 34398198] (IHC, Mouse)
• D Pradella, G Deflorian, A Pezzotta, A Di Matteo, E Belloni, D Campolungo, A Paradisi, M Bugatti, W Vermi, M Campioni, A Chiapparin, L Scietti, F Forneris, C Giampietro, N Volf, M Rehman, S Zacchigna, MP Paronetto, A Pistocchi, A Eichmann, P Mehlen, C Ghigna A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis Nature Communications, 2021-08-11;12(1):4872. 2021-08-11 [PMID: 34381052] (IHC, Human)
• TR Penny, Y Pham, AE Sutherland, J Lee, G Jenkin, MC Fahey, SL Miller, CA McDonald Umbilical cord blood therapy modulates neonatal hypoxic ischemic brain injury in both females and males Scientific Reports, 2021-08-04;11(1):15788. 2021-08-04 [PMID: 34349144] (IHC, Rat)
• C Buhrmann, A Brockmuell, AL Mueller, P Shayan, M Shakibaei Curcumin Attenuates Environment-Derived Osteoarthritis by Sox9/NF-kB Signaling Axis International Journal of Molecular Sciences, 2021-07-16;22(14):. 2021-07-16 [PMID: 34299264] (ICC, Immunoprecipitation, Western Blot, Human)
• Hrvoje Punda, Snjezana Mardesic, Natalija Filipovic, Ivona Kosovic, Benjamin Benzon, Marin Ogorevc et al. Expression Pattern of 5-HT (Serotonin) Receptors during Normal Development of the Human Spinal Cord and Ganglia and in Fetus with Cervical Spina Bifida International Journal of Molecular Sciences 7/7/2021 [PMID: 34298938]
• C Buhrmann, A Brockmuell, C Harsha, AB Kunnumakka, P Kubatka, BB Aggarwal, M Shakibaei Evidence That Tumor Microenvironment Initiates Epithelial-To-Mesenchymal Transition and Calebin A can Suppress it in Colorectal Cancer Cells Frontiers in Pharmacology, 2021-07-02;12(0):699842. 2021-07-02 [PMID: 34276382] (ICC, Western Blot, Human)
• ML Wegscheid, C Anastasaki, KA Hartigan, OM Cobb, JB Papke, JN Traber, SM Morris, DH Gutmann Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis Cell Reports, 2021-07-06;36(1):109315. 2021-07-06 [PMID: 34233200] (IHC, Human)
• H Nakashima, K Tsujimura, K Irie, T Imamura, CA Trujillo, M Ishizu, M Uesaka, M Pan, H Noguchi, K Okada, K Aoyagi, T Andoh-Noda, H Okano, AR Muotri, K Nakashima MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling Cell Reports, 2021-05-18;35(7):109124. 2021-05-18 [PMID: 34010654] (ICC, Human, Mouse)
• Zineb Bouredji, Dounia Hamoudi, Laetitia Marcadet, Anteneh Argaw, Jérôme Frenette Testing the efficacy of a human full-length OPG-Fc analog in a severe model of cardiotoxin-induced skeletal muscle injury and repair Molecular Therapy - Methods & Clinical Development 6/11/2021 [PMID: 33997104]
• Lars Fuhrmann, Saskia Lindner, Alexander-Thomas Hauser, Clemens Höse, Oliver Kretz, Clemens D. Cohen et al. Effects of Environmental Conditions on Nephron Number: Modeling Maternal Disease and Epigenetic Regulation in Renal Development International Journal of Molecular Sciences 4/16/2021 [PMID: 33923831]
• Lars Fuhrmann, Saskia Lindner, Alexander-Thomas Hauser, Clemens Höse, Oliver Kretz, Clemens D. Cohen et al. Effects of Environmental Conditions on Nephron Number: Modeling Maternal Disease and Epigenetic Regulation in Renal Development International Journal of Molecular Sciences 2021-04-16 [PMID: 33923831] (Immunohistochemistry, Mouse)
• Eva Moreno, Shusil K. Pandit, Mathilda J. M. Toussaint, Laura Bongiovanni, Liesbeth Harkema, Saskia C. van Essen et al. Atypical E2Fs either Counteract or Cooperate with RB during Tumorigenesis Depending on Tissue Context Cancers (Basel) 4/23/2021 [PMID: 33922435]
• T Ingwersen, C Linnenberg, E D'Acunto, S Temori, I Paolucci, D Wasilewski, B Mohammadi, J Kirchmair, RC Glen, E Miranda, M Glatzel, G Galliciott G392E neuroserpin causing the dementia FENIB is secreted from cells but is not synaptotoxic Scientific Reports, 2021-04-22;11(1):8766. 2021-04-22 [PMID: 33888787] (ICC, IHC, Mouse)
• MT Dang, MV Gonzalez, KS Gaonkar, KS Rathi, P Young, S Arif, L Zhai, Z Alam, S Devalaraja, TKJ To, IW Folkert, P Raman, JL Rokita, D Martinez, JN Taroni, JA Shapiro, CS Greene, C Savonen, F Mafra, H Hakonarson, T Curran, M Haldar Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality Cell Reports, 2021-03-30;34(13):108917. 2021-03-30 [PMID: 33789113] (IHC, Mouse)
• Takashi Kato, Daisuke Murata, Robert A. Anders, Hiromi Sesaki, Miho Iijima Nuclear PTEN and p53 suppress stress-induced liver cancer through distinct mechanisms Biochemical and Biophysical Research Communications 4/1/2021 [PMID: 33667713]
• Elijah D Lowenstein, Aleksandra Rusanova, Jonas Stelzer, Marc Hernaiz-Llorens, Adrian E Schroer, Ekaterina Epifanova et al. Olig3 regulates early cerebellar development eLife 2/16/2021 [PMID: 33591268]
• M Recasens, B Almolda, J Pérez-Clau, IL Campbell, B González, B Castellano Chronic exposure to IL-6 induces a desensitized phenotype of the microglia Journal of Neuroinflammation, 2021-01-22;18(1):31. 2021-01-22 [PMID: 33482848] (IHC, Mouse)
• M Tajan, M Hennequart, EC Cheung, F Zani, AK Hock, N Legrave, ODK Maddocks, RA Ridgway, D Athineos, A Suárez-Bon, RL Ludwig, L Novellasde, N Angelis, VSW Li, G Vlachogian, N Valeri, N Mainolfi, V Suri, A Friedman, M Manfredi, K Blyth, OJ Sansom, KH Vousden Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy Nature Communications, 2021-01-14;12(1):366. 2021-01-14 [PMID: 33446657] (IHC, Mouse)
• S Titus, KJ Szymanska, B Musul, V Turan, E Taylan, R Garcia-Mil, S Mehta, K Oktay Individual-oocyte transcriptomic analysis shows that genotoxic chemotherapy depletes human primordial follicle reserve�in vivo by triggering proapoptotic pathways without growth activation Scientific Reports, 2021-01-11;11(1):407. 2021-01-11 [PMID: 33431979] (IHC, Human)
• KM Schukken, Y Zhu, PL Bakker, MH Koster, L Harkema, SA Youssef, A de Bruin, F Foijer Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice Scientific Reports, 2021-01-08;11(1):68. 2021-01-08 [PMID: 33420244] (IHC, Mouse)
• Alessia Caramello, Christophe Galichet, Karine Rizzoti, Robin Lovell-Badge Dentate gyrus development requires a cortical hem-derived astrocytic scaffold eLife 1/4/2021 [PMID: 33393905]
• DH Yeom, YS Lee, I Ryu, S Lee, B Sung, HB Lee, D Kim, JH Ahn, E Ha, YS Choi, SH Lee, WK You ABL001, a Bispecific Antibody Targeting VEGF and DLL4, with Chemotherapy, Synergistically Inhibits Tumor Progression in Xenograft Models International Journal of Molecular Sciences, 2020-12-29;22(1):. 2020-12-29 [PMID: 33383646] (IHC, Mouse)
• J Copeland, M Simoes-Cos Post-transcriptional tuning of FGF signaling mediates neural crest induction Proceedings of the National Academy of Sciences of the United States of America, 2020-12-21;117(52):33305-33316. 12/21/2020 [PMID: 33376218]
• MM Menger, P Bremer, C Scheuer, MF Rollmann, BJ Braun, SC Herath, M Orth, T Später, T Pohlemann, MD Menger, T Histing Pantoprazole impairs fracture healing in aged mice Scientific Reports, 2020-12-23;10(1):22376. 2020-12-23 [PMID: 33361800] (Western Blot, Mouse)
• Y Arioka, E Shishido, I Kushima, T Suzuki, R Saito, A Aiba, D Mori, N Ozaki Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons EBioMedicine, 2020-12-17;63(0):103138. 2020-12-17 [PMID: 33341442] (ICC, Human)
• K Hua, L Wang, J Sun, N Zhou, Y Zhang, F Ji, L Jing, Y Yang, W Xia, Z Hu, F Pan, X Chen, B Yao, Z Guo Impairment of Pol &amp;beta-related DNA Base-excision Repair Leads to Ovarian Aging in Mice Aging (Albany NY), 2020-11-20;12(0):. 11/20/2020 [PMID: 33223510]
• Subrajaa Manohar, Alberto Camacho-Magallanes, Camilo Echeverria, Crystal D. Rogers Cadherin-11 Is Required for Neural Crest Specification and Survival Frontiers in Physiology 10/30/2020 [PMID: 33192560]
• Subrajaa Manohar, Alberto Camacho-Magallanes, Camilo Echeverria, Crystal D. Rogers Cadherin-11 Is Required for Neural Crest Specification and Survival Frontiers in Physiology 2020-10-30 [PMID: 33192560] (Immunohistochemistry, Chicken)
• J Choi, DH Lee, H Jang, SY Park, JW Seol Naringenin exerts anticancer effects by inducing tumor cell death and inhibiting angiogenesis in malignant melanoma International Journal of Medical Sciences, 2020-10-18;17(18):3049-3057. 2020-10-18 [PMID: 33173425] (ICC, Mouse)
• Kuijpers M, Kochlamazashvili G, Stumpf A et al. Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum Neuron 10/28/2020 [PMID: 33157003]
• B Di Marco, EE Crouch, B Shah, C Duman, MF Paredes, C Ruiz de Al, EJ Huang, J Alfonso Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon Cell Rep, 2020-10-13;33(2):108256. 2020-10-13 [PMID: 33053356] (IHC, Mouse)
• Olivia J. Marola, Stephanie B. Syc-Mazurek, Gareth R. Howell, Richard T. Libby Endothelin 1-induced retinal ganglion cell death is largely mediated by JUN activation Cell Death & Disease 9/26/2020 [PMID: 32980857]
• Shashank Gandhi, Erica J Hutchins, Krystyna Maruszko, Jong H Park, Matthew Thomson, Marianne E Bronner Bimodal function of chromatin remodeler Hmga1 in neural crest induction and Wnt-dependent emigration eLife 9/23/2020 [PMID: 32965216]
• Xuhui Dong, Hua Yang, Xiangtian Zhou, Xiaoling Xie, Dongliang Yu, Luming Guo et al. LIM-Homeodomain Transcription Factor LHX4 Is Required for the Differentiation of Retinal Rod Bipolar Cells and OFF-Cone Bipolar Subtypes Cell Reports 9/15/2020 [PMID: 32937137]
• S Funcke, TR Werner, M Hein, BM Ulmer, A Hansen, T Eschenhage, MN Hirt Effects of the Delta Opioid Receptor Agonist DADLE in a Novel Hypoxia-Reoxygenation Model on Human and Rat-Engineered Heart Tissue: A Pilot Study Biomolecules, 2020-09-11;10(9):. 2020-09-11 [PMID: 32932811] (IHC, Rat)
• Tiyasha Sarkar, Nisha Patro, Ishan Kumar Patro Neuronal changes and cognitive deficits in a multi-hit rat model following cumulative impact of early life stressors Biology Open 9/15/2020 [PMID: 32878878]
• Linghe Xi, Thomas Carroll, Irina Matos, Ji-Dung Luo, Lisa Polak, H Amalia Pasolli et al. m6A RNA methylation impacts fate choices during skin morphogenesis eLife 8/26/2020 [PMID: 32845239]
• MJ Nokin, E Darbo, C Travert, B Drogat, A Lacouture, S San José, N Cabrera, B Turcq, V Prouzet-Ma, M Falcone, A Villanueva, H Wang, M Herfs, M Mosteiro, PA Jänne, JL Pujol, A Maraver, M Barbacid, E Nadal, D Santamaría, C Ambrogio Inhibition of DDR1 enhances in vivo chemosensitivity in KRAS-mutant lung adenocarcinoma JCI Insight, 2020-08-06;5(15):. 2020-08-06 [PMID: 32759499] (IHC, Mouse)
• Pieter R Norden, Amélie Sabine, Ying Wang, Cansaran Saygili Demir, Ting Liu, Tatiana V Petrova et al. Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation eLife 6/8/2020 [PMID: 32510325]
• J Auzmendi-I, A Saenz-Anto, I Mikelez-Al, E Carrasco-G, M Tellaetxe-, CH Lawrie, N Sampron, AL Cortajaren, A Matheu Characterization of a new small-molecule inhibitor of HDAC6 in glioblastoma Cell Death Dis, 2020-06-02;11(6):417. 2020-06-02 [PMID: 32488056] (IHC, Human)
• F Chang, SJ Kong, L Wang, BK Choi, H Lee, C Kim, JM Kim, K Park Targeting Actomyosin Contractility Suppresses Malignant Phenotypes of Acute Myeloid Leukemia Cells Int J Mol Sci, 2020-05-14;21(10):. 2020-05-14 [PMID: 32422910] (IHC, Mouse)
• J Aldaregia, P Errarte, A Olazagoiti, M Gimeno, JJ Uriz, TR Gershon, I Garcia, A Matheu Erbb4 Is Required for Cerebellar Developmentand Malignant Phenotype of Medulloblastoma Cancers (Basel), 2020-04-17;12(4):. 2020-04-17 [PMID: 32316671] (ICC, IHC, Mouse)
• D'Adamo S, Cetrullo S, Guidotti S et al. Spermidine rescues the deregulated autophagic response to oxidative stress of osteoarthritic chondrocytes Free Radic. Biol. Med. 4/16/2020 [PMID: 32305648]
• Xiqian Lan, Vinod Kumar, Alok Jha, Rukhsana Aslam, Haichao Wang, Kehong Chen et al. EDA2R mediates podocyte injury in high glucose milieu Biochimie 2020-07-01 [PMID: 32304771] (Western Blot, Mouse)
• Xiqian Lan, Vinod Kumar, Alok Jha, Rukhsana Aslam, Haichao Wang, Kehong Chen et al. EDA2R mediates podocyte injury in high glucose milieu Biochimie 7/1/2020 [PMID: 32304771]
• NJ Yates, KW Feindel, A Mehnert, R Beare, S Quick, D Blache, JJ Pillow, RW Hunt Ex Vivo MRI Analytical Methods and Brain Pathology in Preterm Lambs Treated with Postnatal Dexamethasone � Brain Sci, 2020-04-03;10(4):. 2020-04-03 [PMID: 32260193] (IHC, Lamb)
• Hughes KR, Schofield Z, Dalby MJ et al. The early life microbiota protects neonatal mice from pathological small intestinal epithelial cell shedding FASEB J 4/8/2020 [PMID: 32253791]
• MA Khan, T Shamma, S Kazmi, A Altuhami, HA Ahmed, AM Assiri, DC Broering Hypoxia-induced complement dysregulation is associated with microvascular impairments in mouse tracheal transplants J Transl Med, 2020-03-31;18(1):147. 2020-03-31 [PMID: 32234039] (IHC, Mouse)
• Rogers M. Brown, Joel C. Nelson, Hongyuan Zhang, Amy E. Kiernan, Andrew K. Groves Notch-mediated lateral induction is necessary to maintain vestibular prosensory identity during inner ear development Developmental Biology 6/1/2020 [PMID: 32147304]
• Zhu X, Hatfield J, Sullivan Jk et Al. Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy J Neuroinflammation 3/4/2020 [PMID: 32127016]
• Laurine Gagniac, Mariam Rusidzé, Frederic Boudou, Stephanie Cagnet, Marine Adlanmerini, Pauline Jeannot et al. Membrane expression of the estrogen receptor ER alpha is required for intercellular communications in the mammary epithelium Development 3/1/2020 [PMID: 32098763]
• Z Ying, S Beronja Embryonic Barcoding of Equipotent Mammary Progenitors Functionally Identifies Breast Cancer Drivers Cell Stem Cell, 2020-02-13;0(0):. 2020-02-13 [PMID: 32059806] (IHC, Transgenic Mouse)
• Xu Zhang, Zhengwei Li, Wei Ji, Xilong Chen, Qiang Gao, Dajin Li et al. Influence mechanism of miRNA‑144 on proliferation and apoptosis of osteosarcoma cells Oncology Letters 12/10/2019 [PMID: 31966078]
• P Aldaz, M Otaegi-Uga, A Saenz-Anto, M Garcia-Pug, M Moreno-Val, JM Flores, D Gerovska, MJ Arauzo-Bra, N Samprón, A Matheu, E Carrasco-G SOX9 promotes tumor progression through the axis BMI1-p21CIP Sci Rep, 2020-01-15;10(1):357. 2020-01-15 [PMID: 31941916] (IF, Human)
• A Malhotra, M Castillo-M, BJ Allison, AE Sutherland, I Nitsos, Y Pham, CA McDonald, MC Fahey, GR Polglase, G Jenkin, SL Miller Neurovascular effects of umbilical cord blood-derived stem cells in growth-restricted newborn lambs : UCBCs for perinatal brain injury Stem Cell Res Ther, 2020-01-08;11(1):17. 2020-01-08 [PMID: 31915068]
• K Boric, S Mardesic, D Martinovic, M Radic, I Tadin Hadj, K Vukojevic, I Kosovic, I Solic, S Zekic Toma, M Saraga-Bab Expression of apoptotic and proliferation factors in gastric mucosa of patients with systemic sclerosis correlates with form of the disease Sci Rep, 2019-12-05;9(1):18461. 2019-12-05 [PMID: 31804582] (IHC-P, Human)
• LG Jones, A Vaida, LM Thompson, FI Ikuomola, JH Caamaño, MD Burkitt, F Miyajima, JM Williams, BJ Campbell, DM Pritchard, CA Duckworth NF-kappaB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells Cell Death Dis, 2019-11-26;10(12):896. 2019-11-26 [PMID: 31772152] (IHC, Mouse)
• E Grall, V Gourain, A Naïr, E Martin, MC Birling, JN Freund, I Duluc Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs Cell Death Dis, 2019-10-24;10(11):812. 2019-10-24 [PMID: 31649239] (IHC-P, Mouse)
• Olivia J. Marola, Stephanie B. Syc-Mazurek, Richard T. Libby DDIT3 (CHOP) contributes to retinal ganglion cell somal loss but not axonal degeneration in DBA/2J mice Cell Death Discovery 10/10/2019 [PMID: 31632741]
• Olivia J. Marola, Stephanie B. Syc-Mazurek, Richard T. Libby DDIT3 (CHOP) contributes to retinal ganglion cell somal loss but not axonal degeneration in DBA/2J mice Cell Death Discovery 2019-10-10 [PMID: 31632741] (Immunohistochemistry, Mouse)
• F Jaudon, M Chiacchiar, M Albini, S Ferroni, F Benfenati, F Cesca Kidins220/ARMS controls astrocyte calcium signaling and neuron-astrocyte communication Cell Death Differ., 2019-10-17;27(5):1505-1519. 2019-10-17 [PMID: 31624352] (ICC, Human, Mouse)
• Xiaocheng Zhao, Pavel Nedvetsky, Fabio Stanchi, Anne-Clemence Vion, Oliver Popp, Kerstin Zühlke et al. Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1 eLife 10/3/2019 [PMID: 31580256]
• Weiyi Tang, Megan L Martik, Yuwei Li, Marianne E Bronner Cardiac neural crest contributes to cardiomyocytes in amniotes and heart regeneration in zebrafish eLife 8/8/2019 [PMID: 31393264]
• Weiyi Tang, Megan L Martik, Yuwei Li, Marianne E Bronner Cardiac neural crest contributes to cardiomyocytes in amniotes and heart regeneration in zebrafish eLife 2019-08-08 [PMID: 31393264] (Immunohistochemistry, Zebrafish)
• Seo Rin Kim, Kai Jiang, Mikolaj Ogrodnik, Xiaojun Chen, Xiang-Yang Zhu, Hannah Lohmeier et al. Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin Translational Research 11/1/2019 [PMID: 31356770]
• Yuan Ni, Dan Xu, Feng Lv, Yang Wan, Guanlan Fan, Wen Zou et al. Prenatal ethanol exposure induces susceptibility to premature ovarian insufficiency Journal of Endocrinology 10/1/2019 [PMID: 31344684]
• Kefei Nina Li, Prachi Jain, Catherine Hua He, Flora Chae Eun, Sangjo Kang, Tudorita Tumbar Skin vasculature and hair follicle cross-talking associated with stem cell activation and tissue homeostasis eLife 7/25/2019 [PMID: 31343406]
• Sung Wook Park, Jennifer Nhieu, Yi-Wei Lin, Li-Na Wei All-trans retinoic acid attenuates isoproterenol-induced cardiac dysfunction through Crabp1 to dampen CaMKII activation European Journal of Pharmacology 9/5/2019 [PMID: 31238067]
• S Zhao, M Thakur, AW Klattenhof, D Kidane Aberrant DNA Polymerase Beta Enhances H. pylori Infection Induced Genomic Instability and Gastric Carcinogenesis in Mice Cancers (Basel), 2019-06-18;11(6):. 2019-06-18 [PMID: 31216714] (IHC, Mouse)
• Chanbin Lee, Jieun Kim, Sihyung Wang, Sumi Sung, Namgyu Kim, Hyun-Hee Lee et al. Hepatoprotective Effect of Kombucha Tea in Rodent Model of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis International Journal of Molecular Sciences 5/13/2019 [PMID: 31086120]
• Chanbin Lee, Jieun Kim, Sihyung Wang, Sumi Sung, Namgyu Kim, Hyun-Hee Lee et al. Hepatoprotective Effect of Kombucha Tea in Rodent Model of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis International Journal of Molecular Sciences 2019-05-13 [PMID: 31086120] (Immunohistochemistry, Mouse)
• Zsuzsanna Szvicsek, Ádám Oszvald, Lili Szabó, Gyöngyvér Orsolya Sándor, Andrea Kelemen, András Áron Soós et al. Extracellular vesicle release from intestinal organoids is modulated by Apc mutation and other colorectal cancer progression factors Cellular and Molecular Life Sciences 2019-06-01 [PMID: 31028424] (Immunohistochemistry, Human)
• Zsuzsanna Szvicsek, Ádám Oszvald, Lili Szabó, Gyöngyvér Orsolya Sándor, Andrea Kelemen, András Áron Soós et al. Extracellular vesicle release from intestinal organoids is modulated by Apc mutation and other colorectal cancer progression factors Cellular and Molecular Life Sciences 6/1/2019 [PMID: 31028424]
• S Krishna-Su, S Singer, M Armaka, JM Banales, K Holzer, P Schirmache, H Walczak, G Kollias, M Pasparakis, V Kondylis RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury Cell Death Differ., 2019-04-15;0(0):. 4/15/2019 [PMID: 30988397]
• Mingming Cao, Zhuoran Zhang, Su Han, Xi Lu Butyrate inhibits the proliferation and induces the apoptosis of colorectal cancer HCT116 cells via the deactivation of mTOR/S6K1 signaling mediated partly by SIRT1 downregulation Molecular Medicine Reports 3/1/2019 [PMID: 30864709]
• D Aprile, F Fruscione, S Baldassari, M Fadda, D Ferrante, A Falace, E Buhler, J Sartorelli, A Represa, P Baldelli, F Benfenati, F Zara, A Fassio TBC1D24 regulates axonal outgrowth and membrane trafficking at the growth cone in rodent and human neurons Cell Death Differ., 2019-03-11;0(0):. 2019-03-11 [PMID: 30858606] (ICC, Rat)
• P Antas, L Novellasde, A Kucharska, I Massie, J Carvalho, D Oukrif, E Nye, M Novelli, VSW Li SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating ?-Catenin Nuclear Localization Cell Rep, 2019-02-26;26(9):2266-2273.e4. 2019-02-26 [PMID: 30811977] (IHC-P, Mouse)
• Hailan Zhao, Ruiqing Wang, Mingxia Ye, Lan Zhang Genipin protects against H2O2-induced oxidative damage in�retinal pigment epithelial cells by promoting Nrf2 signaling International Journal of Molecular Medicine 12/12/2018 [PMID: 30569096]
• BA Brown, GM Connolly, CEJ Mill, H Williams, GD Angelini, JL Johnson, SJ George Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells Aging Cell, 2018-12-12;0(0):e12844. 2018-12-12 [PMID: 30548452] (ICC, Mouse)
• Debadrita Bhattacharya, Megan Rothstein, Ana Paula Azambuja, Marcos Simoes-Costa Control of neural crest multipotency by Wnt signaling and the Lin28/let-7 axis eLife 12/6/2018 [PMID: 30520734]
• O Bover, T Justo, PNG Pereira, J Facucho-Ol, JM Inácio, JS Ramalho, IJ Domian, JA Belo Loss of Ccbe1 affects cardiac-specification and cardiomyocyte differentiation in mouse embryonic stem cells PLoS ONE, 2018-10-03;13(10):e0205108. 2018-10-03 [PMID: 30281646] (Flow Cytometry, Mouse)
• Atul Malhotra, Margie Castillo-Melendez, Beth J. Allison, Amy E. Sutherland, Ilias Nitsos, Yen Pham et al. Neuropathology as a consequence of neonatal ventilation in premature growth-restricted lambs American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 12/1/2018 [PMID: 30230932]
• Vieceli FM, Bronner ME. Leukocyte Receptor Tyrosine Kinase interacts with secreted midkine to promote survival of migrating neural crest cells. Development 9/18/2018 [PMID: 30228102]
• Justyna Ulanska-Poutanen, Jakub Mieczkowski, Chao Zhao, Katarzyna Konarzewska, Beata Kaza, Hartmut BF Pohl et al. Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells eLife 9/17/2018 [PMID: 30222103]
• RK Zwick, MC Rudolph, BA Shook, B Holtrup, E Roth, V Lei, A Van Keymeu, V Seewaldt, S Kwei, J Wysolmersk, MS Rodeheffer, V Horsley Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation Nat Commun, 2018-09-04;9(1):3592. 2018-09-04 [PMID: 30181538] (IHC, Mouse)
• M Ouarné, C Bouvard, G Boneva, C Mallet, J Ribeiro, A Desroches-, E Soleilhac, E Tillet, O Peyruchaud, S Bailly BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer J. Exp. Clin. Cancer Res., 2018-08-30;37(1):209. 2018-08-30 [PMID: 30165893] (IHC-P, Mouse)
• A López-Muño, FE Nicolás, D García-Mor, AB Pérez-Oliv, MI Navarro-Me, MA Hernández-, A Herrera-Es, S Torres-Mar, RM Ruiz-Vázqu, V Garre, V Mulero An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages Sci Rep, 2018-08-24;8(1):12802. 2018-08-24 [PMID: 30143654] (IHC-P, Zebrafish)
• Douglas J. Hermes, Changqing Xu, Justin L. Poklis, Micah J. Niphakis, Benjamin F. Cravatt, Ken Mackie et al. Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS Neuropharmacology 10/1/2018 [PMID: 30114402]
• Nicole A. Edwards, Andrew J. Watson, Dean H. Betts Knockdown of p66Shc Alters Lineage-Associated Transcription Factor Expression in Mouse Blastocysts Stem Cells and Development 11/1/2018 [PMID: 30091687]
• P Shen, J Chen, M Pan The protective effects of total paeony glycoside on ischemia/reperfusion injury in H9C2 cells via inhibition of the PI3K/Akt signaling pathway Mol Med Rep, 2018-07-30;18(3):3332-3340. 2018-07-30 [PMID: 30066927] (Western Blot, Rat)
• M Baek, M Kim, JS Lim, LD Morales, J Hernandez, S Mummidi, S Williams-B, IS Jang, AT Tsin, DJ Kim Epidermal-specific deletion of TC-PTP promotes UVB-induced epidermal cell survival through the regulation of Flk-1/JNK signaling Cell Death Dis, 2018-06-28;9(7):730. 2018-06-28 [PMID: 29955047] (Human)
• ML Piacentino, ME Bronner Intracellular attenuation of BMP signaling via CKIP-1/Smurf1 is essential during neural crest induction PLoS Biol., 2018-06-27;16(6):e2004425. 2018-06-27 [PMID: 29949573] (IHC-P, Chicken)
• Henri Johannes Haapanen, Johanna Herajärvi, Hannu-Pekka Honkanen, Caius Mustonen, Hannu Tuominen, Ulla Puistola et al. Immunohistochemical Analysis of the Spinal Cord Ischemia– Effect of Remote Ischemic Preconditioning in a Porcine Model The Heart Surgery Forum 5/29/2018 [PMID: 29893682]
• A Martín-Rui, L Peña, A González-G, LT Díez-Córdo, S Cáceres, JC Illera Effects of indole-3-carbinol on steroid hormone profile and tumor progression in a mice model of canine inflammatory mammarycancer BMC Cancer, 2018-06-04;18(1):626. 6/4/2018 [PMID: 29866056]
• I Cohen, D Zhao, C Bar, VJ Valdes, KL Dauber-Dec, MB Nguyen, M Nakayama, M Rendl, WA Bickmore, H Koseki, D Zheng, E Ezhkova PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification Cell Stem Cell, 2018-05-03;22(5):726-739.e7. 2018-05-03 [PMID: 29727681] (IHC, Mouse)
• R Barbieri, A Contestabi, MG Ciardo, N Forte, A Marte, P Baldelli, F Benfenati, F Onofri Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice Oncotarget, 2018-04-10;9(27):18760-18774. 2018-04-10 [PMID: 29721159] (IHC, Mouse)
• E Indersie, KB Hooks, C Capdeviell, M Fabre, N Dugot-Sena, A Desplat, S Lepreux, A Merched, CF Grosset, M Hagedorn Tracking cellular and molecular changes in a species-specific manner during experimental tumor progression in vivo Oncotarget, 2018-03-01;9(22):16149-16162. 2018-03-01 [PMID: 29662633] (IHC, Human)
• P Srikanth, VN Lagomarsin, CR Muratore, SC Ryu, A He, WM Taylor, C Zhou, M Arellano, TL Young-Pear Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids Transl Psychiatry, 2018-04-12;8(1):77. 2018-04-12 [PMID: 29643329] (ICC, Mouse)
• PLN da Costa, D Wynne, T Fifis, L Nguyen, M Perini, C Christophi The kallikrein-Kinin system modulates the progression of colorectal liver metastases in a mouse model BMC Cancer, 2018-04-04;18(1):382. 2018-04-04 [PMID: 29618333] (IHC, Mouse)
• C Fassier, A Fréal, L Gasmi, C Delphin, D Ten Martin, S De Gois, M Tambalo, C Bosc, P Mailly, C Revenu, L Peris, S Bolte, S Schneider-, C Houart, F Nothias, JC Larcher, A Andrieux, J Hazan Motor axon navigation relies on Fidgetin-like 1-driven microtubule plus end dynamics J. Cell Biol., 2018-03-13;0(0):. 3/13/2018 [PMID: 29535193]
• N Antoniou, D Vlachakis, A Memou, E Leandrou, PE Valkimadi, K Melachroin, DB Re, S Przedborsk, WT Dauer, L Stefanis, HJ Rideout A motif within the armadillo repeat of Parkinson&#039;s-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway Sci Rep, 2018-02-22;8(1):3455. 2018-02-22 [PMID: 29472595] (ICC, Mouse)
• Filipa Neto, Alexandra Klaus-Bergmann, Yu Ting Ong, Silvanus Alt, Anne-Clémence Vion, Anna Szymborska et al. YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development eLife 2/5/2018 [PMID: 29400648]
• Filipa Neto, Alexandra Klaus-Bergmann, Yu Ting Ong, Silvanus Alt, Anne-Clémence Vion, Anna Szymborska et al. YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development eLife 2018-02-05 [PMID: 29400648] (Immunohistochemistry, Transgenic Mouse)
• JM Povedano, P Martinez, R Serrano, Á Tejera, G Gómez-Lópe, M Bobadilla, JM Flores, F Bosch, MA Blasco Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres Elife, 2018-01-30;7(0):. 2018-01-30 [PMID: 29378675] (IHC-P, Mouse)
• D Skuk, JP Tremblay The Process of Engraftment of Myogenic Cells in Skeletal Muscles of Primates: Understanding Clinical Observations and Setting Directions in Cell Transplantation Research Cell Transplant, 2017-11-01;26(11):1763-1779. 2017-11-01 [PMID: 29338383] (IHC, Primate)
• N Dreyer-And, AS Almeida, P Jensen, M Kamand, J Okarmus, T Rosenberg, SD Friis, A Martínez S, M Blaabjerg, BW Kristensen, T Skrydstrup, JB Gramsberge, HLA Vieira, M Meyer Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells PLoS ONE, 2018-01-16;13(1):e0191207. 2018-01-16 [PMID: 29338033] (ICC, Human)
• C Ambrogio, J Köhler, ZW Zhou, H Wang, R Paranal, J Li, M Capelletti, C Caffarra, S Li, Q Lv, S Gondi, JC Hunter, J Lu, R Chiarle, D Santamaría, KD Westover, PA Jänne KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS Cell, 2018-01-11;0(0):. 2018-01-11 [PMID: 29336889] (IHC-P, Mouse)
• María Laura Saiz, Danay Cibrian, Marta Ramírez-Huesca, Daniel Torralba, Olga Moreno-Gonzalo, Francisco Sánchez-Madrid Tetraspanin CD9 Limits Mucosal Healing in Experimental Colitis Frontiers in Immunology 2017-12-19 [PMID: 29312336] (Immunohistochemistry, Mouse, Transgenic Mouse)
• María Laura Saiz, Danay Cibrian, Marta Ramírez-Huesca, Daniel Torralba, Olga Moreno-Gonzalo, Francisco Sánchez-Madrid Tetraspanin CD9 Limits Mucosal Healing in Experimental Colitis Frontiers in Immunology 12/19/2017 [PMID: 29312336]
• CA Lyon, H Williams, R Bianco, SJ Simmonds, BA Brown, KS Wadey, FCT Smith, JL Johnson, SJ George Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression Sci Rep, 2017-12-11;7(1):17342. 2017-12-11 [PMID: 29229950] (ICC, IHC, Human, Mouse)
• MK Shim, HY Yoon, S Lee, MK Jo, J Park, JH Kim, SY Jeong, IC Kwon, K Kim Caspase-3/-7-Specific Metabolic Precursor for Bioorthogonal Tracking of Tumor Apoptosis Sci Rep, 2017-11-30;7(1):16635. 2017-11-30 [PMID: 29192289] (Western Blot, Human)
• Rosa A. Uribe, Stephanie S. Hong, Marianne E. Bronner Retinoic acid temporally orchestrates colonization of the gut by vagal neural crest cells Developmental Biology 1/1/2018 [PMID: 29108781]
• Sihyung Wang, Chanbin Lee, Jieun Kim, Jeongeun Hyun, Minso Lim, Hyuk-Jin Cha et al. Tumor necrosis factor-inducible gene 6 protein ameliorates chronic liver damage by promoting autophagy formation in mice Experimental & Molecular Medicine 9/1/2017 [PMID: 28935975]
• Guadalupe J. Ortiz, Yanjie Li, Sean M. Post, Vinod Pant, Shunbin Xiong, Connie A. Larsson et al. Contrasting effects of an Mdm2 functional polymorphism on tumor phenotypes Oncogene 1/1/2018 [PMID: 28925402]
• M Dezest, M Le Bechec, L Chavatte, V Desauziers, B Chaput, JL Grolleau, P Descargues, C Nizard, S Schnebert, S Lacombe, AL Bulteau Oxidative damage and impairment of protein quality control systems in keratinocytes exposed to a volatile organic compounds cocktail Sci Rep, 2017-09-06;7(1):10707. 2017-09-06 [PMID: 28878258] (IHC, IHC-P, Human)
• Andrew Muroyama, Terry Lechler A transgenic toolkit for visualizing and perturbing microtubules reveals unexpected functions in the epidermis eLife 9/4/2017 [PMID: 28869035]
• M. A. Breau, I. Bonnet, J. Stoufflet, J. Xie, S. De Castro, S. Schneider-Maunoury Extrinsic mechanical forces mediate retrograde axon extension in a developing neuronal circuit Nature Communications 8/17/2017 [PMID: 28819208]
• M. A. Breau, I. Bonnet, J. Stoufflet, J. Xie, S. De Castro, S. Schneider-Maunoury Extrinsic mechanical forces mediate retrograde axon extension in a developing neuronal circuit Nature Communications 2017-08-17 [PMID: 28819208] (Immunohistochemistry, Zebrafish)
• C Tu, R Xu, M Koleti, J Zoldan Glycogen synthase kinase-3 inhibition sensitizes human induced pluripotent stem cells to thiol-containing antioxidants induced apoptosis Stem Cell Res, 2017-07-22;23(0):182-187. 2017-07-22 [PMID: 28772167] (Functional Assay, Human)
• Wei Rose Xie, Hsin-I Jen, Michelle L. Seymour, Szu-Ying Yeh, Fred A. Pereira, Andrew K. Groves et al. An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and Motor Impairment The Journal of Neuroscience 9/6/2017 [PMID: 28729444]
• DJ Flanagan, N Barker, C Nowell, H Clevers, M Ernst, TJ Phesse, E Vincan Loss of the Wnt receptor Frizzled7 in the gastric epithelium is deleterious and triggers rapid repopulation in vivo Dis Model Mech, 2017-06-09;0(0):. 2017-06-09 [PMID: 28600348] (IHC, Mouse)
• F Oozeer, LL Yates, C Dean, CJ Formstone A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin Sci Rep, 2017-05-12;7(1):1880. 2017-05-12 [PMID: 28500339] (IHC, Mouse)
• F Cartier, E Indersie, S Lesjean, J Charpentie, KB Hooks, A Ghousein, A Desplat, N Dugot-Sena, V Trézéguet, F Sagliocco, M Hagedorn, CF Grosset New tumor suppressor microRNAs target glypican-3 in human liver cancer Oncotarget, 2017-06-20;0(0):. 2017-06-20 [PMID: 28476031] (IHC, Chicken)
• Lynne A Murray, Rebecca Dunmore, Ana Camelo, Carla A Da Silva, Malin J Gustavsso, David M Habiel, Tillie L Hackett, Cory M Hogaboam, Matthew A Sleeman, Darryl A Knight Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium. Respiratory Research, 2017-05-03;0(0):1465-993X. 2017-05-03 [PMID: 28468623] (IHC, Mouse)
• AA Chassot, M Le Rolle, M Jourden, MM Taketo, NB Ghyselinck, MC Chaboissie Constitutive WNT/CTNNB1 activation triggers spermatogonial stem cell proliferation and germ cell depletion Dev. Biol., 2017-04-26;0(0):. 2017-04-26 [PMID: 28456466] (IHC-P, Mouse)
• JY Jang, SY Choi, I Park, DY Park, K Choe, P Kim, YK Kim, BJ Lee, M Hirashima, Y Kubota, JW Park, SY Cheng, A Nagy, YJ Park, K Alitalo, M Shong, GY Koh VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis EMBO Mol Med, 2017-06-01;0(0):. 2017-06-01 [PMID: 28438786] (IHC, Mouse)
• S Grasso, J Chapelle, V Salemme, S Aramu, I Russo, N Vitale, L Verdun di, K Dallaglio, I Castellano, A Amici, G Centonze, N Sharma, S Lunardi, S Cabodi, F Cavallo, A Lamolinara, L Stramucci, E Moiso, P Provero, A Albini, A Sapino, J Staaf, PP Di Fiore, G Bertalot, S Pece, D Tosoni, S Confalonie, M Iezzi, P Di Stefano, E Turco, P Defilippi The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries Nat Commun, 2017-03-16;8(0):14797. 2017-03-16 [PMID: 28300085] (IHC, Mouse)
• JC Klein, K Moses, G Zelinskyy, S Sody, J Buer, S Lang, I Helfrich, U Dittmer, CJ Kirschning, S Brandau Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth Nat Commun, 2017-03-16;8(0):14600. 2017-03-16 [PMID: 28300057] (IHC, Mouse)
• Larissa M. S. Lemos, Fabio Miyajima, Geovane R. C. Castilho, Domingos Tabajara O. Martins, D. Mark Pritchard, Michael D. Burkitt Hexane Extracts of Calophyllum brasiliense Inhibit the Development of Gastric Preneoplasia in Helicobacter felis Infected INS-Gas Mice Frontiers in Pharmacology 2/27/2017 [PMID: 28289390]
• J Deshmukh, R Pofahl, I Haase Epidermal Rac1 regulates the DNA damage response and protects from UV-light-induced keratinocyte apoptosis and skin carcinogenesis Cell Death Dis, 2017-03-09;8(3):e2664. 3/9/2017 [PMID: 28277539]
• Sean P. Arlauckas, Manoj Kumar, Anatoliy V. Popov, Harish Poptani, Edward J. Delikatny Near infrared fluorescent imaging of choline kinase alpha expression and inhibition in breast tumors Oncotarget 3/7/2017 [PMID: 28157707]
• KR Hughes, LC Harnisch, C Alcon-Gine, S Mitra, CJ Wright, J Ketskemety, D van Sinder, AJ Watson, LJ Hall Bifidobacterium breve reduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD88-dependent manner Open Biol, 2017-01-01;7(1):. 2017-01-01 [PMID: 28123052] (IHC-P, Mouse)
• T Revenco, G Lapouge, V Moers, S Broh‚e, PA Sotiropoul Low Dose Radiation Causes Skin Cancer In Mice And Has A Differential Effect on Distinct Epidermal Stem Cells Stem Cells, 2017-02-01;0(0):. 2017-02-01 [PMID: 28100039] (IHC-P, Mouse)
• Y He, H Huang, C Farischon, D Li, Z Du, K Zhang, X Zheng, S Goodin Combined effects of atorvastatin and aspirin on growth and apoptosis in human prostate cancer cells Oncol. Rep, 2017-01-04;37(2):953-960. 2017-01-04 [PMID: 28075470] (ICC, Human)
• Autophagy deficient keratinocytes display increased DNA damage, senescence and aberrant lipid composition after oxidative stress in vitro and in vivo Redox Biol, 2016-12-18;11(0):219-230. 2016-12-18 [PMID: 28012437] (Western Blot, Mouse)
• cMyc Regulates the Size of the Premigratory Neural Crest Stem Cell Pool Cell Rep, 2016-12-06;17(10):2648-2659. 2016-12-06 [PMID: 27926868] (IHC, Mouse)
• Simon X Liang Proliferation, differentiation and migration of SCA1(-)/CD31(-) cardiac side population cells in vitro and in vivo Int. J. Cardiol., 2016-11-09;0(0):. 2016-11-09 [PMID: 27847151] (IHC, Mouse)
• Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations PLoS ONE, 2016-11-10;11(11):e0166053. 2016-11-10 [PMID: 27832104] (IHC, Human)
• Karina S Cramer Axonal Cleaved Caspase-3 Regulates Axon Targeting and Morphogenesis in the Developing Auditory Brainstem Front Neural Circuits, 2016-10-24;10(0):84. 2016-10-24 [PMID: 27822180] (IHC, Chicken)
• Ingunn Holen, Diane V. Lefley, Sheila E. Francis, Sarah Rennicks, Steven Bradbury, Robert E. Coleman et al. IL-1 drives breast cancer growth and bone metastasis in vivo Oncotarget 11/15/2016 [PMID: 27765923]
• Amy M Lange, Ekaterina S Altynova, Giang N Nguyen, Denise E Sabatino Overexpression of factor VIII after AAV delivery is transiently associated with cellular stress in hemophilia A mice Molecular Therapy - Methods & Clinical Development 9/28/2016 [PMID: 27738645]
• Kirsten S. Evonuk, Sumanth D. Prabhu, Martin E. Young, Tara M. DeSilva Myocardial ischemia/reperfusion impairs neurogenesis and hippocampal-dependent learning and memory Brain, Behavior, and Immunity 3/1/2017 [PMID: 27600185]
• CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex Stem Cell Reports, 2016-07-12;7(1):69-79. 2016-07-12 [PMID: 27411104] (IHC, Mouse)
• M-C De Cian Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary Oncogene, 2016-06-06;0(0):. 2016-06-06 [PMID: 27270435] (IHC-P, Mouse)
• Hirofumi Noguchi DNA Methyltransferase 1 Is Indispensable for Development of the Hippocampal Dentate Gyrus J Neurosci, 2016-06-01;36(22):6050-68. 6/1/2016 [PMID: 27251626]
• Eleni Panousopoulou, Carl Hobbs, Ivor Mason, Jeremy B. A. Green, Caroline J. Formstone Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body Development 5/15/2016 [PMID: 27190040]
• Defining the cellular lineage hierarchy in the interfollicular epidermis of adult skin Nat. Cell Biol., 2016-05-16;18(6):619-31. 2016-05-16 [PMID: 27183471] (IHC, Mouse)
• XIANG LIU, HAI-BIN SHENG, RUI MA, JUAN-MEI YANG, WEN-WEI LUO, XIAO-YU YANG et al. Notch signaling is active in normal mouse middle ear epithelial cells Experimental and Therapeutic Medicine 5/1/2016 [PMID: 27168786]
• Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice J Neurosci, 2016-04-27;36(17):4758-70. 2016-04-27 [PMID: 27122034] (IHC, Mouse)
• V Clausse, A R Goloudina, B Uyanik, E Y Kochetkova, S Richaud, O A Fedorova et al. Wee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapy Cell Death & Disease 4/14/2016 [PMID: 27077811]
• SR Berkowicz, TJ Featherby, Z Qu, A Giousoh, NA Borg, JI Heng, JC Whisstock, PI Bird Brinp1 (-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density Mol Autism, 2016-03-31;7(0):22. 2016-03-31 [PMID: 27042284] (IHC-Fr, Mouse)
• KATARZYNA JAKUBOWSKA, KATARZYNA GUZIŃSKA-USTYMOWICZ, WALDEMAR FAMULSKI, DARIUSZ CEPOWICZ, DOROTA JAGODZIŃSKA, ANNA PRYCZYNICZ Reduced expression of caspase-8 and cleaved caspase-3 in pancreatic ductal adenocarcinoma cells Oncology Letters 3/1/2016 [PMID: 26998093]
• Eleni Panousopoulou, Carl Hobbs, Ivor Mason, Jeremy B. A. Green, Caroline J. Formstone Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body. Journal of Cell Science 2016-05-01 [PMID: 26989131] (Immunohistochemistry, Mouse)
• Eleni Panousopoulou, Carl Hobbs, Ivor Mason, Jeremy B. A. Green, Caroline J. Formstone Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body Journal of Cell Science 5/1/2016 [PMID: 26989131]
• Maartje van der Heijden, Cheryl D. Zimberlin, Anna M. Nicholson, Selcuk Colak, Richard Kemp, Sybren L. Meijer et al. Bcl-2 is a critical mediator of intestinal transformation Nature Communications 3/9/2016 [PMID: 26956214]
• H.K. Brown, P.D. Ottewell, C.A. Evans, R.E. Coleman, I. Holen A single administration of combination therapy inhibits breast tumour progression in bone and modifies both osteoblasts and osteoclasts Journal of Bone Oncology 2012-09-01 [PMID: 26909255] (Immunohistochemistry, Mouse)
• H.K. Brown, P.D. Ottewell, C.A. Evans, R.E. Coleman, I. Holen A single administration of combination therapy inhibits breast tumour progression in bone and modifies both osteoblasts and osteoclasts Journal of Bone Oncology 9/1/2012 [PMID: 26909255]
• Jacob F, Yonis A, Cuello F, Luther P, Schulze T, Eder A, Streichert T, Mannhardt I, Hirt M, Schaaf S, Stenzig J, Force T, Eschenhagen T, Hansen A Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue. PLoS ONE, 2016-02-03;11(2):e0145937. 2016-02-03 [PMID: 26840448] (IHC-P, Rat)
• Yasuhito Watanabe, Michaela K. Müller, Jakob von Engelhardt, Rolf Sprengel, Peter H. Seeburg, Hannah Monyer Age-Dependent Degeneration of Mature Dentate Gyrus Granule Cells Following NMDA Receptor Ablation Frontiers in Molecular Neuroscience 1/12/2016 [PMID: 26793056]
• Rocío López-Posadas, Christoph Becker, Claudia Günther, Stefan Tenzer, Kerstin Amann, Ulrike Billmeier et al. Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation Journal of Clinical Investigation 2016-01-11 [PMID: 26752649] (Immunohistochemistry, Mouse)
• Rocío López-Posadas, Christoph Becker, Claudia Günther, Stefan Tenzer, Kerstin Amann, Ulrike Billmeier et al. Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation Journal of Clinical Investigation 1/11/2016 [PMID: 26752649]
• Marianne Petro, Hayder Jaffer, Jun Yang, Shushi Kabu, Viola B. Morris, Vinod Labhasetwar Tissue plasminogen activator followed by antioxidant-loaded nanoparticle delivery promotes activation/mobilization of progenitor cells in infarcted rat brain Biomaterials 3/1/2016 [PMID: 26735970]
• Kelly Airiau, Valérie Prouzet-Mauléon, Benoit Rousseau, Arnaud Pigneux, Marie Jeanneteau, Manon Giraudon et al. Synergistic cooperation between ABT-263 and MEK1/2 inhibitor: effect on apoptosis and proliferation of acute myeloid leukemia cells Oncotarget 1/5/2016 [PMID: 26625317]
• Amelkina O, Zschockelt L, Painer J, Serra R, Villaespesa F, Braun B, Jewgenow K Apoptosis-Related Factors in the Luteal Phase of the Domestic Cat and Their Involvement in the Persistence of Corpora Lutea in Lynx. PLoS ONE, 2015-11-24;10(11):e0143414. 2015-11-24 [PMID: 26599641] (IHC-P, Feline)
• Uribe RA, Buzzi AL, Bronner ME et al. Histone demethylase KDM4B regulates otic vesicle invagination via epigenetic control of Dlx3 expression J Cell Biol 11/25/2015 [PMID: 26598618]
• Onur Birol, Takahiro Ohyama, Renée K. Edlund, Katerina Drakou, Pantelis Georgiades, Andrew K. Groves The mouse Foxi3 transcription factor is necessary for the development of posterior placodes Developmental Biology 1/1/2016 [PMID: 26550799]
• JD Aridas, CA McDonald, MC Paton, T Yawno, AE Sutherland, I Nitsos, Y Pham, M Ditchfield, MC Fahey, F Wong, A Malhotra, M Castillo-M, K Bhakoo, EM Wallace, G Jenkin, SL Miller Cord blood mononuclear cells prevent neuronal apoptosis in response to perinatal asphyxia in the newborn lamb J. Physiol. (Lond.), 2015-12-14;594(5):1421-35. 2015-12-14 [PMID: 26527561] (IHC-P, Mouse)
• Roger Ramcharan, Tamara Aleksic, Wilfride Petnga Kamdoum, Shan Gao, Sophia X. Pfister, Jordan Tanner et al. IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide Oncotarget 10/15/2015 [PMID: 26497996]
• Géraldine Mitou, Julie Frentzel, Aurore Desquesnes, Sophie Le Gonidec, Talal AlSaati, Isabelle Beau et al. Targeting autophagy enhances the anti-tumoral action of crizotinib in ALK-positive anaplastic large cell lymphoma Oncotarget 8/17/2015 [PMID: 26338968]
• Géraldine Mitou, Julie Frentzel, Aurore Desquesnes, Sophie Le Gonidec, Talal AlSaati, Isabelle Beau et al. Targeting autophagy enhances the anti-tumoral action of crizotinib in ALK-positive anaplastic large cell lymphoma Oncotarget 2015-08-17 [PMID: 26338968] (Immunohistochemistry, Xenograft)
• Wong J, Chen L, Huang Y, Sehba F, Friedel R, Zou H Attenuation of Cerebral Ischemic Injury in Smad1 Deficient Mice. PLoS ONE, 2015-08-28;10(8):e0136967. 2015-08-28 [PMID: 26317208] (IHC-Fr, Mouse)
• Quereda V, Porlan E, Canamero M, Dubus P, Malumbres M An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress. Cell Death Differ, 2015-08-21;23(3):430-41. 2015-08-21 [PMID: 26292757] (IHC-P, Mouse)
• Alejandra González-Loyola, Gonzalo Fernández-Miranda, Marianna Trakala, David Partida, Kumiko Samejima, Hiromi Ogawa et al. Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development Molecular and Cellular Biology 10/1/2015 [PMID: 26240282]
• Alejandra González-Loyola, Gonzalo Fernández-Miranda, Marianna Trakala, David Partida, Kumiko Samejima, Hiromi Ogawa et al. Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development Molecular and Cellular Biology 2015-10-01 [PMID: 26240282] (Immunohistochemistry, Transgenic Mouse)
• Douglas T, Champagne C, Morizot A, Lapointe J, Saleh M The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice. J Immunol, 2015-07-27;195(5):2365-73. 2015-07-27 [PMID: 26216893] (IHC-P, Mouse)
• Aoife O'Shaughnessy-Kirwan, Jason Signolet, Ita Costello, Sarah Gharbi, Brian Hendrich Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification Development 8/1/2015 [PMID: 26116663]
• Aoife O'Shaughnessy-Kirwan, Jason Signolet, Ita Costello, Sarah Gharbi, Brian Hendrich Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification Development 2015-08-01 [PMID: 26116663] (Immunohistochemistry, Mouse)
• Levet S, Ouarne M, Ciais D, Coutton C, Subileau M, Mallet C, Ricard N, Bidart M, Debillon T, Faravelli F, Rooryck C, Feige J, Tillet E, Bailly S BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus. Proc Natl Acad Sci U S A, 2015-06-08;112(25):E3207-15. 2015-06-08 [PMID: 26056270] (IHC, Mouse)
• Sophal Cheat, Juliana R. Gerez, Juliette Cognié, Imourana Alassane-Kpembi, Ana Paula F. L. Bracarense, Isabelle Raymond-Letron et al. Nivalenol Has a Greater Impact than Deoxynivalenol on Pig Jejunum Mucosa in Vitro on Explants and in Vivo on Intestinal Loops Toxins (Basel) 5/29/2015 [PMID: 26035490]
• Shushi Kabu, Hayder Jaffer, Marianne Petro, Dave Dudzinski, Desiree Stewart, Amy Courtney et al. Blast-Associated Shock Waves Result in Increased Brain Vascular Leakage and Elevated ROS Levels in a Rat Model of Traumatic Brain Injury PLOS ONE 5/29/2015 [PMID: 26024446]
• Sun H, Lou Y, Porturas T, Morrissey S, Luo G, Qi J, Ruan Q, Shi S, Chen Y Exacerbated experimental colitis in TNFAIP8-deficient mice. J Immunol, 2015-05-06;194(12):5736-42. 2015-05-06 [PMID: 25948814] (IHC-P, Mouse)
• Brindle N, Joyce J, Rostker F, Lawlor E, Swigart-Brown L, Evan G, Hanahan D, Shchors K Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer. PLoS ONE, 2015-04-30;10(4):e0120348. 2015-04-30 [PMID: 25927437] (IHC, Mouse)
• Sharma S, Chintala N, Vadrevu S, Patel J, Karbowniczek M, Markiewski M Pulmonary alveolar macrophages contribute to the premetastatic niche by suppressing antitumor T cell responses in the lungs. J Immunol, 2015-04-24;194(11):5529-38. 2015-04-24 [PMID: 25911761] (Flow Cytometry, Mouse)
• Declercq , Annelies, Chiers , Koen, Van den Broeck , Wim, Dewulf , Jeroen, Eeckhaut , Venessa, Cornelissen , Maria, Bossier , Peter, Haesebrouck , Freddy, Decostere , Annemie Interactions of highly and low virulent Flavobacterium columnare isolates with gill tissue in carp and rainbow trout. Vet Res, 2015-03-06;46(0):25. 2015-03-06 [PMID: 25889257] (IHC-P, Fish - Cyprinus carpio (Carp), Fish - Oncorhynchus mykiss (Rainbow Trout))
• Sesen J, Dahan P, Scotland S, Saland E, Dang V, Lemarie A, Tyler B, Brem H, Toulas C, Cohen-Jonathan Moyal E, Sarry J, Skuli N Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response. PLoS ONE, 2015-04-13;10(4):e0123721. 2015-04-13 [PMID: 25867026] (IHC, Mouse)
• Scott C, Cha K, Rao R, Liddle C, George J, Gunton J Hepatocyte-specific deletion of ARNT (aryl hydrocarbon Receptor Nuclear Translocator) results in altered fibrotic gene expression in the thioacetamide model of liver injury. PLoS ONE, 2015-03-26;10(3):e0121650. 2015-03-26 [PMID: 25812120] (IHC-P, Mouse)
• Matsuda T, Murao N, Katano Y, Juliandi B, Kohyama J, Akira S, Kawai T, Nakashima K TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus. Nat Commun, 2015-03-09;6(0):6514. 2015-03-09 [PMID: 25751136] (ICC, Mouse)
• Luyet C, Schulze K, Sayar B, Howald D, Muller E, Galichet A Preclinical studies identify non-apoptotic low-level caspase-3 as therapeutic target in pemphigus vulgaris. PLoS ONE, 2015-03-06;10(3):e0119809. 2015-03-06 [PMID: 25748204] (ICC, Mouse)
• Michael D Burkitt, Abdalla F Hanedi, Carrie A Duckworth, Jonathan M Williams, Joseph M Tang, Lorraine A O'Reilly et al. NF-kappa B1, NF-kappa B2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice The Journal of Pathology 7/1/2015 [PMID: 25727407]
• Hirofumi Noguchi, Ayaka Kimura, Naoya Murao, Taito Matsuda, Masakazu Namihira, Kinichi Nakashima Expression of DNMT1 in neural stem/precursor cells is critical for survival of newly generated neurons in the adult hippocampus Neuroscience Research 2015-06-01 [PMID: 25659757] (Immunohistochemistry, Transgenic Mouse)
• Hirofumi Noguchi, Ayaka Kimura, Naoya Murao, Taito Matsuda, Masakazu Namihira, Kinichi Nakashima Expression of DNMT1 in neural stem/precursor cells is critical for survival of newly generated neurons in the adult hippocampus Neuroscience Research 6/1/2015 [PMID: 25659757]
• Sawhney S, Hood K, Shaw A, Braithwaite A, Stubbs R, Hung N, Royds J, Slatter T Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a 133p53alpha mimic. PLoS ONE, 2015-02-02;10(2):e0116270. 2015-02-02 [PMID: 25643152] (IHC-P, Mouse)
• Petersson , Monika, Reuter , Karen, Brylka , Heike, Kraus , Andreas, Schettina , Peter, Niemann , Catherin Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours. Nat Commun, 2015-01-22;6(0):5874. 2015-01-22 [PMID: 25608467] (IHC, Mouse)
• Moyon S, Dubessy A, Aigrot M, Trotter M, Huang J, Dauphinot L, Potier M, Kerninon C, Melik Parsadaniantz S, Franklin R, Lubetzki C Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration. J Neurosci, 2015-01-07;35(1):4-20. 2015-01-07 [PMID: 25568099] (IHC-Fr, Mouse)
• Mracsko E, Liesz A, Stojanovic A, Lou W, Osswald M, Zhou W, Karcher S, Winkler F, Martin-Villalba A, Cerwenka A, Veltkamp R Antigen dependently activated cluster of differentiation 8-positive T cells cause perforin-mediated neurotoxicity in experimental stroke. J Neurosci, 2014-12-10;34(50):16784-95. 2014-12-10 [PMID: 25505331] (ICC, Mouse)
• Hayley Davis, Shazia Irshad, Mukesh Bansal, Hannah Rafferty, Tatjana Boitsova, Chiara Bardella et al. Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside of the crypt base stem cell niche Nature Medicine 1/1/2015 [PMID: 25419707]
• Yen T, Alison M, Goodlad R, Otto W, Jeffery R, Cook H, Wright N, Poulsom R Epidermal growth factor attenuates tubular necrosis following mercuric chloride damage by regeneration of indigenous, not bone marrow-derived cells. J Cell Mol Med, 2014-11-11;19(2):463-73. 2014-11-11 [PMID: 25389045] (IHC-P, Mouse)
• Mary E. Blue, Mary Ann Wilson, Claude A. Beaty, Timothy J. George, George J. Arnaoutakis, Kara A. Haggerty et al. Brain Injury in Canine Models of Cardiac Surgery Journal of Neuropathology & Experimental Neurology 12/1/2014 [PMID: 25383634]
• H. Shang, W. Meng, D. M. Sloboda, S. Li, L. Ehrlich, A. Plagemann et al. Effects of Maternal Dexamethasone Treatment Early in Pregnancy on Glucocorticoid Receptors in the Ovine Placenta Reproductive Sciences 5/1/2015 [PMID: 25332218]
• H. Shang, W. Meng, D. M. Sloboda, S. Li, L. Ehrlich, A. Plagemann et al. Effects of Maternal Dexamethasone Treatment Early in Pregnancy on Glucocorticoid Receptors in the Ovine Placenta Reproductive Sciences 2015-05-01 [PMID: 25332218] (Immunohistochemistry, Ewes)
• Huarong Huang, Yan He, Xiao-Xing Cui, Susan Goodin, Hong Wang, Zhi Yun Du et al. Potent Inhibitory Effect of δ-Tocopherol on Prostate Cancer Cells Cultured in Vitro and Grown As Xenograft Tumors in Vivo Journal of Agricultural and Food Chemistry 11/5/2014 [PMID: 25322450]
• Anna Pilutin, Kamila Misiakiewicz-Has, Agnieszka Kolasa, Irena Baranowska-Bosiacka, Mariola Marchlewicz, Barbara Wiszniewska The immunoexpression of androgen receptor, estrogen receptors alpha and beta, vanilloid type 1 receptor and cytochrome p450 aromatase in rats testis chronically treated with letrozole, an aromatase inhibitor Folia Histochemica et Cytobiologica 2014-10-10 [PMID: 25308736] (Immunohistochemistry, Rat)
• Anna Pilutin, Kamila Misiakiewicz-Has, Agnieszka Kolasa, Irena Baranowska-Bosiacka, Mariola Marchlewicz, Barbara Wiszniewska The immunoexpression of androgen receptor, estrogen receptors alpha and beta, vanilloid type 1 receptor and cytochrome p450 aromatase in rats testis chronically treated with letrozole, an aromatase inhibitor Folia Histochemica et Cytobiologica 10/10/2014 [PMID: 25308736]
• Heather M Schmitt, Heather R Pelzel, Cassandra L Schlamp, Robert W Nickells Histone deacetylase 3 (HDAC3) plays an important role in retinal ganglion cell death after acute optic nerve injury Molecular Neurodegeneration 12/1/2014 [PMID: 25261965]
• Fowler , Anna-Kat, Thompson , Jeremy, Chen , Lixia, Dagda , Marisela, Dertien , Janet, Dossou , Katina S, Moaddel , Ruin, Bergeson , Susan E, Kruman , Inna I Differential sensitivity of prefrontal cortex and hippocampus to alcohol-induced toxicity. PLoS ONE, 2014-09-04;9(9):e106945. 2014-09-04 [PMID: 25188266] (IHC, Mouse)
• Lindgren G, Ekblad L, Vallon-Christersson J, Kjellen E, Gebre-Medhin M, Wennerberg J Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma. BMC Cancer, 2014-09-02;14(0):648. 2014-09-02 [PMID: 25182342] (IHC, Mouse)
• Hanane Lanaya, Anuradha Natarajan, Karin Komposch, Liang Li, Nicole Amberg, Lei Chen et al. EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation Nature Cell Biology 10/1/2014 [PMID: 25173978]
• Marius Dannappel, Katerina Vlantis, Snehlata Kumari, Apostolos Polykratis, Chun Kim, Laurens Wachsmuth et al. RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis Nature 9/4/2014 [PMID: 25132550]
• Willner D, Cohen-Yeshurun A, Avidan A, Ozersky V, Shohami E, Leker R Short term morphine exposure in vitro alters proliferation and differentiation of neural progenitor cells and promotes apoptosis via mu receptors. PLoS ONE, 2014-07-29;9(7):e103043. 2014-07-29 [PMID: 25072277] (IHC, Mouse)
• Park D, Lee J, Park I, Choi D, Lee S, Song S, Hwang Y, Hong K, Nakaoka Y, Makinen T, Kim P, Alitalo K, Hong Y, Koh G Lymphatic regulator PROX1 determines Schlemm&#039;s canal integrity and identity. J Clin Invest, 2014-07-25;124(9):3960-74. 2014-07-25 [PMID: 25061877] (IHC, Mouse)
• Deng M, Luo X, Pan L, Yang H, Xie X, Liang G, Huang L, Hu F, Kiernan A, Gan L LMO4 functions as a negative regulator of sensory organ formation in the mammalian cochlea. J Neurosci, 2014-07-23;34(30):10072-7. 2014-07-23 [PMID: 25057208] (IHC, Mouse)
• H Ehlken, S Krishna-Subramanian, L Ochoa-Callejero, V Kondylis, N E Nadi, B K Straub et al. Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout Cell Death & Differentiation 11/1/2014 [PMID: 24971483]
• H Ehlken, S Krishna-Subramanian, L Ochoa-Callejero, V Kondylis, N E Nadi, B K Straub et al. Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout Cell Death & Differentiation 2014-11-01 [PMID: 24971483] (Immunohistochemistry, Transgenic Mouse)
• Grahammer F, Haenisch N, Steinhardt F, Sander L, Roerden M, Arnold F, Cordts T, Wanner N, Reichardt W, Kerjaschki D, Ruegg M, Hall M, Moulin P, Busch H, Boerries M, Walz G, Artunc F, Huber T mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proc Natl Acad Sci U S A, 2014-06-23;111(27):E2817-26. 2014-06-23 [PMID: 24958889] (IHC, Mouse)
• Wiener Z, Band A, Kallio P, Hogstrom J, Hyvonen V, Kaijalainen S, Ritvos O, Haglund C, Kruuna O, Robine S, Louvard D, Ben-Neriah Y, Alitalo K Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-beta. Proc Natl Acad Sci U S A, 2014-05-13;111(21):E2229-36. 2014-05-13 [PMID: 24825889] (Flow Cytometry, IHC, Mouse)
• Krabbe C, Bak S, Jensen P, von Linstow C, Martinez Serrano A, Hansen C, Meyer M Influence of oxygen tension on dopaminergic differentiation of human fetal stem cells of midbrain and forebrain origin. PLoS ONE, 2014-05-02;9(5):e96465. 2014-05-02 [PMID: 24788190] (ICC, Mouse)
• Kumar L, Chou J, Yee C, Borzutzky A, Vollmann E, von Andrian U, Park S, Hollander G, Manis J, Poliani P, Geha R Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. J Exp Med, 2014-04-21;211(5):929-42. 2014-04-21 [PMID: 24752297] (IHC, Mouse)
• Losa D, Kohler T, Bellec J, Dudez T, Crespin S, Bacchetta M, Boulanger P, Hong S, Morel S, Nguyen T, van Delden C, Chanson M Pseudomonas aeruginosa-induced apoptosis in airway epithelial cells is mediated by gap junctional communication in a JNK-dependent manner. J Immunol, 2014-04-14;192(10):4804-12. 2014-04-14 [PMID: 24733844] (Western Blot, Human)
• Martinez P, Ferrara-Romeo I, Flores J, Blasco M Essential role for the TRF2 telomere protein in adult skin homeostasis. Aging Cell, 2014-04-14;13(4):656-68. 2014-04-14 [PMID: 24725274] (IHC-P, Mouse)
• Edlund R, Ohyama T, Kantarci H, Riley B, Groves A Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers. Dev Biol, 2014-03-18;390(1):1-13. 2014-03-18 [PMID: 24650709] (IHC, Mouse)
• Chu H, Liao Y, Novak J, Hu Z, Merkin J, Shymkiv Y, Braeckman B, Dorovkov M, Nguyen A, Clifford P, Nagele R, Harrison D, Ellis R, Ryazanov A Germline quality control: eEF2K stands guard to eliminate defective oocytes. Dev Cell, 2014-02-27;28(5):561-72. 2014-02-27 [PMID: 24582807] (IHC, Mouse)
• Mona Foth, Imran Ahmad, Bas W. G. van Rhijn, Theodorus van der Kwast, Andre M. Bergman, Louise King et al. Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice The Journal of Pathology 6/1/2014 [PMID: 24519156]
• Shir Lin Koh, E. I. Ager, P. L. N. Costa, C. Malcontenti-Wilson, V. Muralidharan, C. Christophi Blockade of the renin–angiotensin system inhibits growth of colorectal cancer liver metastases in the regenerating liver Clinical & Experimental Metastasis 4/1/2014 [PMID: 24442969]
• Saraga M, Vukojevic K, Krzelj V, Puretic Z, Bocina I, Durdov M, Weber S, Dworniczak B, Ljubanovic D, Saraga-Babic M Mechanism of cystogenesis in nephrotic kidneys: a histopathological study. BMC Nephrol, 2014-01-08;15(0):3. 2014-01-08 [PMID: 24397250] (IHC, Human)
• Brookes , Steven J, Barron , Martin J, Boot-Handford , Ray, Kirkham , Jennifer, Dixon , Michael Endoplasmic reticulum stress in amelogenesis imperfecta and phenotypic rescue using 4-phenylbutyrate. Hum Mol Genet, 2013-12-20;23(9):2468-80. 2013-12-20 [PMID: 24362885] (IHC, Mouse)
• Fan J, Ponferrada V, Sato T, Vemaraju S, Fruttiger M, Gerhardt H, Ferrara N, Lang R Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling. Development, 2013-12-18;141(2):448-59. 2013-12-18 [PMID: 24353059] (IHC, Mouse)
• Xu J, Xiao M, Jakovcevski I, Sivukhina E, Hargus G, Cui Y, Irintchev A, Schachner M, Bernreuther C The extracellular matrix glycoprotein tenascin-R regulates neurogenesis during development and in the adult dentate gyrus of mice. J Cell Sci, 2013-12-11;127(0):641-52. 2013-12-11 [PMID: 24338367] (IHC, Mouse)
• Tzeng , Tsai-Ten, Tsay , Huey-Jen, Chang , Luping, Hsu , Chia-Lin, Lai , Tzu-Hsua, Huang , Fong-Lee, Shiao , Young-Ji Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid. J Biomed Sci, 2013-12-06;20(0):90. 2013-12-06 [PMID: 24313976] (IHC-Fr, Mouse)
• Kerosuo L, Bronner M Biphasic influence of Miz1 on neural crest development by regulating cell survival and apical adhesion complex formation in the developing neural tube. Mol Biol Cell, 2013-12-04;25(3):347-55. 2013-12-04 [PMID: 24307680] (IHC, Chicken)
• Wahlin , Karl J, Enke , Raymond, Fuller , John A, Kalesnykas , Giedrius, Zack , Donald J, Merbs , Shannath Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death. PLoS ONE, 2013-11-11;8(11):e79140. 2013-11-11 [PMID: 24244436] (IHC-Fr, Chicken, Mouse)
• Perez de Castro I, Aguirre-Portoles C, Fernandez-Miranda G, Canamero M, Cowley D, Van Dyke T, Malumbres M Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals. Cancer Res, 2013-11-15;73(22):6804-15. 2013-11-15 [PMID: 24242071] (IHC, Mouse)
• Ling , Xiang, Bao , Feng, Qian , Hao, Liu , Danxia The temporal and spatial profiles of cell loss following experimental spinal cord injury: effect of antioxidant therapy on cell death and functional recovery. BMC Neurosci, 2013-11-18;14(0):146. 2013-11-18 [PMID: 24238557] (IHC, Rat)
• Xi Zheng, Xiao-Xing Cui, Tin Oo Khor, Ying Huang, Robert S DiPaola, Susan Goodin et al. Inhibitory Effect of a gamma -Tocopherol-Rich Mixture of Tocopherols on the Formation and Growth of LNCaP Prostate Tumors in Immunodeficient Mice Cancers (Basel) 9/28/2011 [PMID: 24213110]
• Xi Zheng, Xiao-Xing Cui, Tin Oo Khor, Ying Huang, Robert S DiPaola, Susan Goodin et al. Inhibitory Effect of a gamma -Tocopherol-Rich Mixture of Tocopherols on the Formation and Growth of LNCaP Prostate Tumors in Immunodeficient Mice Cancers (Basel) 2011-09-28 [PMID: 24213110] (Immunohistochemistry, Xenograft)
• Piotr Eder, Liliana Lykowska-Szuber, Iwona Krela-Kazmierczak, Kamila Stawczyk-Eder, Karolina Sterzynska, Katarzyna Iwanik et al. Anti-TNF antibodies do not induce the apoptosis of lamina propria mononuclear cells in uninflamed intestinal tissue in patients with Crohn’s disease Folia Histochemica et Cytobiologica 11/7/2013 [PMID: 24203631]
• Olive V, Sabio E, Bennett M, De Jong C, Biton A, McGann J, Greaney S, Sodir N, Zhou A, Balakrishnan A, Foth M, Luftig M, Goga A, Speed T, Xuan Z, Evan G, Wan Y, Minella A, He L A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. Elife, 2013-10-15;2(0):e00822. 2013-10-15 [PMID: 24137534] (IHC, Mouse)
• Florian Sparber, Julia M. Scheffler, Nicole Amberg, Christoph H. Tripp, Valeska Heib, Martin Hermann et al. The late endosomal adaptor molecule p14 (LAMTOR2) represents a novel regulator of Langerhans cell homeostasis Blood 1/9/2014 [PMID: 24092934]
• Jonathan M. Williams, Carrie A. Duckworth, Alastair J. M. Watson, Mark R. Frey, Jennifer C. Miguel, Michael D. Burkitt et al. A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide Disease Models & Mechanisms 9/19/2013 [PMID: 24046352]
• Chan S, Rickert C, Vermi W, Sheehan K, Arthur C, Allen J, White J, Archambault J, Lonardi S, McDevitt T, Bhattacharya D, Lorenzi M, Allred D, Schreiber R Dysregulated STAT1-SOCS1 control of JAK2 promotes mammary luminal progenitor cell survival and drives ERalpha(+) tumorigenesis. Cell Death Differ, 2013-09-13;21(2):234-46. 2013-09-13 [PMID: 24037089] (IHC-P, Mouse)
• Zamli Z, Adams M, Tarlton J, Sharif M Increased chondrocyte apoptosis is associated with progression of osteoarthritis in spontaneous Guinea pig models of the disease. Int J Mol Sci, 2013-08-29;14(9):17729-43. 2013-08-29 [PMID: 23994836] (IHC, Guinea Pig)
• Y. Zhang, Zhen Guan, Brenda Reader, Todd Shawler, Shweta Mandrekar-Colucci, Kun Huang et al. Autonomic Dysreflexia Causes Chronic Immune Suppression after Spinal Cord Injury Journal of Neuroscience 8/7/2013 [PMID: 23926252]
• Hayley Davis, Annabelle Lewis, Axel Behrens, Ian Tomlinson Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines Gut 5/1/2014 [PMID: 23676439]
• Hayley Davis, Annabelle Lewis, Axel Behrens, Ian Tomlinson Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines Gut 2014-05-01 [PMID: 23676439] (Immunohistochemistry, Mouse)
• Hwang J, Hsu C, Yu W, Liu T, Yang W Diet-induced obesity exacerbates auditory degeneration via hypoxia, inflammation, and apoptosis signaling pathways in CD/1 mice. PLoS ONE, 2013-04-26;8(4):e60730. 2013-04-26 [PMID: 23637762] (IHC, Mouse)
• Stott , Simon R, Metzakopian , Emmanoui, Lin , Wei, Kaestner , Klaus H, Hen , Rene, Ang , Siew-Lan Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages. J Neurosci, 2013-05-01;33(18):8022-34. 2013-05-01 [PMID: 23637192] (IHC, Mouse)
• Bradford A. Perez, A. Paiman Ghafoori, Chang-Lung Lee, Samuel M. Johnston, Yifan Li, Jacob G. Moroshek et al. Assessing the Radiation Response of Lung Cancer with Different Gene Mutations Using Genetically Engineered Mice Frontiers in Oncology 4/2/2013 [PMID: 23565506]
• Shakibaei M, Mobasheri A, Lueders C, Busch F, Shayan P, Goel A Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-kappaB and Src protein kinase signaling pathways. PLoS ONE, 2013-02-22;8(2):e57218. 2013-02-22 [PMID: 23451189] (Western Blot, Human)
• Wen-Chi L. Chang, Terry V. Zenser, Harry S. Cooper, Margie L. Clapper Differential response of flat and polypoid colitis-associated colorectal neoplasias to chemopreventive agents and heterocyclic amines Cancer Letters 6/28/2013 [PMID: 23415736]
• Filippo Massa, Serge Garbay, Raymonde Bouvier, Yoshinobu Sugitani, Tetsuo Noda, Marie-Claire Gubler et al. Hepatocyte nuclear factor 1 beta controls nephron tubular development Development 2/15/2013 [PMID: 23362349]
• Crystal D. Rogers, Jacquelyn L. Phillips, Marianne E. Bronner Elk3 is essential for the progression from progenitor to definitive neural crest cell Developmental Biology 2/15/2013 [PMID: 23266330]
• Linh Nguyen, Theodora Fifis, Caterina Malcontenti-Wilson, Lie Sam Chan, Patricia Nunes Luiza Costa, Mehrdad Nikfarjam et al. Spatial morphological and molecular differences within solid tumors may contribute to the failure of vascular disruptive agent treatments BMC Cancer 12/1/2012 [PMID: 23153292]
• E. Myers, E. J. Ehrhart, B. Charles, T. Spraker, T. Gelatt, C. Duncan Apoptosis in Normal and Coxiella burnetii–Infected Placentas From Alaskan Northern Fur Seals (Callorhinus ursinus) Veterinary Pathology 7/1/2013 [PMID: 23125144]
• Raquel Espín, Francisco J. Roca, Sergio Candel, María P. Sepulcre, Juan M. González-Rosa, Francisca Alcaraz-Pérez et al. TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3 Disease Models & Mechanisms 2012-09-08 [PMID: 22956347] (Flow Cytometry, Zebrafish)
• Raquel Espín, Francisco J. Roca, Sergio Candel, María P. Sepulcre, Juan M. González-Rosa, Francisca Alcaraz-Pérez et al. TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3 Disease Models & Mechanisms 9/8/2012 [PMID: 22956347]
• Ann F. Hubbs, Amy M. Cumpston, W. Travis Goldsmith, Lori A. Battelli, Michael L. Kashon, Mark C. Jackson et al. Respiratory and Olfactory Cytotoxicity of Inhaled 2,3-Pentanedione in Sprague-Dawley Rats The American Journal of Pathology 9/1/2012 [PMID: 22894831]
• L. S. Howard, A. Crosby, P. Vaughan, A. Sobolewski, M. Southwood, M. L. Foster et al. Distinct Responses to Hypoxia in Subpopulations of Distal Pulmonary Artery Cells Contribute to Pulmonary Vascular Remodeling in Emphysema Pulmonary Circulation 2012-07-28 [PMID: 22837865] (Immunohistochemistry, Human)
• L. S. Howard, A. Crosby, P. Vaughan, A. Sobolewski, M. Southwood, M. L. Foster et al. Distinct Responses to Hypoxia in Subpopulations of Distal Pulmonary Artery Cells Contribute to Pulmonary Vascular Remodeling in Emphysema Pulmonary Circulation 7/28/2012 [PMID: 22837865]
• Donald E. Thrall, Paolo Maccarini, Paul Stauffer, James Macfall, Marlene Hauck, Stacey Snyder et al. Thermal dose fractionation affects tumour physiological response International Journal of Hyperthermia 7/8/2013 [PMID: 22804741]
• K. A. Giamanco, R. T. Matthews Deconstructing the perineuronal net: Cellular contributions and molecular composition of the neuronal extracellular matrix Neuroscience 8/30/2012 [PMID: 22659016]
• Daniel R. Neill, Vitor E. Fernandes, Laura Wisby, Andrew R. Haynes, Daniela M. Ferreira, Ameera Laher et al. T Regulatory Cells Control Susceptibility to Invasive Pneumococcal Pneumonia in Mice PLoS Pathogens 4/19/2012 [PMID: 22563306]
• Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis. Cell Death Differ., 2012-05-04;19(11):1761-8. 2012-05-04 [PMID: 22555459] (IHC-P, Mouse)
• McIntyre A, Patiar S, Wigfield S Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy. Clin. Cancer Res., 2012-04-12;18(11):3100-11. 2012-04-12 [PMID: 22498007] (IHC, Human)
• Chen T, Heller E, Beronja S, Oshimori N, Stokes N, Fuchs E An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration. Nature, 2012-04-04;485(7396):104-8. 2012-04-04 [PMID: 22495305] (IHC-Fr, Mouse)
• Patrick McDonel, Jeroen Demmers, David W.M. Tan, Fiona Watt, Brian D. Hendrich Sin3a is essential for the genome integrity and viability of pluripotent cells Developmental Biology 3/1/2012 [PMID: 22206758]
• Patrick McDonel, Jeroen Demmers, David W.M. Tan, Fiona Watt, Brian D. Hendrich Sin3a is essential for the genome integrity and viability of pluripotent cells Developmental Biology 2012-03-01 [PMID: 22206758] (Immunohistochemistry, Transgenic Mouse)
• Azadeh Montaseri, Franziska Busch, Ali Mobasheri, Constanze Buhrmann, Constance Aldinger, Jafar Soleimani Rad et al. IGF-1 and PDGF-bb Suppress IL-1 beta -Induced Cartilage Degradation through Down-Regulation of NF-kappa B Signaling: Involvement of Src/PI-3K/AKT Pathway PLoS ONE 12/14/2011 [PMID: 22194879]
• Michell Mario Reimer, Jamie McQueen, Luke Searcy, Gillian Scullion, Barbara Zonta, Anne Desmazieres et al. Rapid Disruption of Axon–Glial Integrity in Response to Mild Cerebral Hypoperfusion The Journal of Neuroscience 12/7/2011 [PMID: 22159130]
• Mai Lan Leong, Ming Gu, Rebecca Speltz Speltz-Paiz, Eleanor I. Stahura, Neli Mottey, Clifford J. Steer et al. Neuronal Loss in the Rostral Ventromedial Medulla in a Rat Model of Neuropathic Pain The Journal of Neuroscience 11/23/2011 [PMID: 22114272]
• Anastasia R. Goloudina, Kan Tanoue, Arlette Hammann, Eric Fourmaux, Xavier Le Guezennec, Dmitry V. Bulavin et al. Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents Proceedings of the National Academy of Sciences 1/10/2012 [PMID: 22065775]
• F Cesca, A Yabe, B Spencer-Dene, A Arrigoni, M Al-Qatari, D Henderson et al. Kidins220/ARMS is an essential modulator of cardiovascular and nervous system development Cell Death & Disease 11/3/2011 [PMID: 22048169]
• F Cesca, A Yabe, B Spencer-Dene, J Scholz-Starke, L Medrihan, C H Maden et al. Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems Cell Death & Differentiation 2012-02-01 [PMID: 22048155] (Western Blot, Mouse)
• F Cesca, A Yabe, B Spencer-Dene, J Scholz-Starke, L Medrihan, C H Maden et al. Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems Cell Death & Differentiation 2/1/2012 [PMID: 22048155]
• Eric R. Ritchey, Kimberly Code, Christopher P. Zelinka, Melissa A. Scott, Andy J. Fischer The chicken cornea as a model of wound healing and neuronal re-innervation Mol Vis 9/21/2011 [PMID: 21976955]
• Alcmène Chalazonitis, Amy A. Tang, Yulei Shang, Tuan D. Pham, Ivy Hsieh, Wanda Setlik et al. Homeodomain Interacting Protein Kinase 2 Regulates Postnatal Development of Enteric Dopaminergic Neurons and Glia via BMP Signaling The Journal of Neuroscience 9/28/2011 [PMID: 21957238]
• Alcmène Chalazonitis, Amy A. Tang, Yulei Shang, Tuan D. Pham, Ivy Hsieh, Wanda Setlik et al. Homeodomain Interacting Protein Kinase 2 Regulates Postnatal Development of Enteric Dopaminergic Neurons and Glia via BMP Signaling The Journal of Neuroscience 2011-09-28 [PMID: 21957238] (Immunohistochemistry, Transgenic Mouse)
• Heikki Takala, Joonas H. Kauppila, Ylermi Soini, Katri S. Selander, Katri S. Vuopala, Petri P. Lehenkari et al. Toll-Like Receptor 9 Is a Novel Biomarker for Esophageal Squamous Cell Dysplasia and Squamous Cell Carcinoma Progression Journal of Innate Immunity 3/11/2011 [PMID: 21876325]
• Kaushal Joshi, Habibe Demir, Ryosuke Yamada, Takeshi Miyazaki, Abhik Ray-Chaudhury, Ichiro Nakano Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens Journal of Visualized Experiments 7/29/2011 [PMID: 21841761]
• Jason Wray, Tüzer Kalkan, Sandra Gomez-Lopez, Dominik Eckardt, Andrew Cook, Rolf Kemler et al. Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation Nature Cell Biology 2011-07-01 [PMID: 21685889] (Flow Cytometry, Mouse)
• Jason Wray, Tüzer Kalkan, Sandra Gomez-Lopez, Dominik Eckardt, Andrew Cook, Rolf Kemler et al. Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation Nature Cell Biology 7/1/2011 [PMID: 21685889]
• Constanze Buhrmann, Ali Mobasheri, Franziska Busch, Constance Aldinger, Ralf Stahlmann, Azadeh Montaseri et al. Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway Journal of Biological Chemistry 8/12/2011 [PMID: 21669872]
• Linghua Qiu, Jaime A. Rivera-Pérez, Zuoshang Xu A Non-Specific Effect Associated with Conditional Transgene Expression Based on Cre-loxP Strategy in Mice PLoS ONE 5/10/2011 [PMID: 21572998]
• Linghua Qiu, Jaime A. Rivera-Pérez, Zuoshang Xu A Non-Specific Effect Associated with Conditional Transgene Expression Based on Cre-loxP Strategy in Mice PLoS ONE 2011-05-10 [PMID: 21572998] (Immunohistochemistry, Mouse)
• Fuxe J, Tabruyn S, Colton K, Zaid H, Adams A, Baluk P, Lashnits E, Morisada T, Le T, O'Brien S, Epstein DM, Koh GY, McDonald DM Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation. Am. J. Pathol., 2011-05-06;178(6):2897-909. 2011-05-06 [PMID: 21550017] (IHC, Mouse)
• Rafael B. Blasco, Sarah Francoz, David Santamaría, Marta Cañamero, Pierre Dubus, Jean Charron et al. c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma Cancer Cell 5/17/2011 [PMID: 21514245]
• Hernandez-Miranda LR, Cariboni A, Faux C, Ruhrberg C, Cho JH, Cloutier JF, Eickholt BJ, Parnavelas JG, Andrews WD Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain. J. Neurosci., 2011-04-20;31(16):6174-87. 2011-04-20 [PMID: 21508241] (IHC-Fr, Mouse)
• Anika Glaschke, Jessica Weiland, Domenico Del Turco, Marianne Steiner, Leo Peichl, Martin Glösmann Thyroid Hormone Controls Cone Opsin Expression in the Retina of Adult Rodents The Journal of Neuroscience 3/30/2011 [PMID: 21451022]
• E Logette, S Schuepbach-Mallepell, M J Eckert, X H Leo, B Jaccard, C Manzl et al. PIDD orchestrates translesion DNA synthesis in response to UV irradiation Cell Death & Differentiation 6/1/2011 [PMID: 21415862]
• Kelleher MA, Palliser HK, Walker DW, Hirst JJ. Sex-dependent effect of a low neurosteroid environment and intrauterine growth restriction on fetal guinea pig brain development. J Endocrinol. 12/13/2010 [PMID: 21149437]
• Elin Hadler-Olsen, Hilde Ljones Wetting, Oddveig Rikardsen, Sonja E. Steigen, Premasany Kanapathippillai, Reidar Grénman et al. Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts Virchows Archiv 12/1/2010 [PMID: 20890764]
• Ni A, Lashnits E, Yao LC et al. Rapid remodeling of airway vascular architecture at birth. Dev Dyn 9/1/2010 [PMID: 20730909]
• Perez CJ, Jaubert J, Guenet JL, Barnhart KF, Ross-Inta CM, Quintanilla VC, Aubin I, Brandon JL, Otto NW, DiGiovanni J, Gimenez-Conti I, Giulivi C, Kusewitt DF, Conti CJ, Benavides F Two hypomorphic alleles of mouse Ass1 as a new animal model of citrullinemia type I and other hyperammonemic syndromes. Am. J. Pathol., 2010-08-19;177(4):1958-68. 2010-08-19 [PMID: 20724589] (IHC-P, Mouse)
• Constanze Buhrmann, Ali Mobasheri, Ulrike Matis, Mehdi Shakibaei Curcumin mediated suppression of nuclear factor-kappa B promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment Arthritis Research & Therapy 7/1/2010 [PMID: 20594343]
• Eleanor I Ager, Way W Chong, Shu-wen Wen, Christopher Christophi Targeting the angiotensin II type 2 receptor (AT2R) in colorectal liver metastases Cancer Cell International 2010-06-28 [PMID: 20584290] (Immunohistochemistry, Mouse)
• Eleanor I Ager, Way W Chong, Shu-wen Wen, Christopher Christophi Targeting the angiotensin II type 2 receptor (AT2R) in colorectal liver metastases Cancer Cell International 6/28/2010 [PMID: 20584290]
• Jason F. Wiggins, Lynnsie Ruffino, Kevin Kelnar, Michael Omotola, Lubna Patrawala, David Brown et al. Development of a Lung Cancer Therapeutic Based on the Tumor Suppressor MicroRNA-34 Cancer Research 2010-07-15 [PMID: 20570894] (Immunohistochemistry, Xenograft)
• Jason F. Wiggins, Lynnsie Ruffino, Kevin Kelnar, Michael Omotola, Lubna Patrawala, David Brown et al. Development of a Lung Cancer Therapeutic Based on the Tumor Suppressor MicroRNA-34 Cancer Research 7/15/2010 [PMID: 20570894]
• Anabela Silva-Fernandes, Maria do Carmo Costa, Sara Duarte-Silva, Pedro Oliveira, Claudia M. Botelho, Luís Martins et al. Motor uncoordination and neuropathology in a transgenic mouse model of Machado–Joseph disease lacking intranuclear inclusions and ataxin-3 cleavage products Neurobiology of Disease 10/1/2010 [PMID: 20510362]
• Sotiropoulou PA, Candi A, Mascre G, De Clercq S, Youssef KK, Lapouge G, Dahl E, Semeraro C, Denecker G, Marine JC, Blanpain C Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death. Nat. Cell Biol., 2010-05-16;12(6):572-82. 2010-05-16 [PMID: 20473297] (Flow Cytometry, ICC, Mouse)
• Mellone N. Marchong, Christine Yurkowski, Clement Ma, Clarellen Spencer, Sanja Pajovic, Brenda L. Gallie Cdh11 Acts as a Tumor Suppressor in a Murine Retinoblastoma Model by Facilitating Tumor Cell Death PLoS Genetics 4/22/2010 [PMID: 20421947]
• Kurt H. Albertine, Mar Janna Dahl, Linda W. Gonzales, Zheng-ming Wang, Drew Metcalfe, Dallas M. Hyde et al. Chronic lung disease in preterm lambs: effect of daily vitamin A treatment on alveolarization American Journal of Physiology-Lung Cellular and Molecular Physiology 7/1/2010 [PMID: 20382748]
• Kurt H. Albertine, Mar Janna Dahl, Linda W. Gonzales, Zheng-ming Wang, Drew Metcalfe, Dallas M. Hyde et al. Chronic lung disease in preterm lambs: effect of daily vitamin A treatment on alveolarization American Journal of Physiology-Lung Cellular and Molecular Physiology 2010-07-01 [PMID: 20382748] (Immunohistochemistry, Ovine)
• Li H, Kloosterman W, Fekete DM MicroRNA-183 family members regulate sensorineural fates in the inner ear. J. Neurosci., 2010-03-03;30(9):3254-63. 2010-03-03 [PMID: 20203184] (IHC, Zebrafish)
• Hashizume H, Falcon BL, Kuroda T, Baluk P, Coxon A, Yu D, Bready JV, Oliner JD, McDonald DM Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth. Cancer Res., 2010-03-02;70(6):2213-23. 2010-03-02 [PMID: 20197469] (IHC, Human)
• Mehdi Shakibaei, Bokyung Sung, Gautam Sethi, Bharat B. Aggarwal TNF-alpha-induced mitochondrial alterations in human T cells requires FADD and caspase-8 activation but not RIP and caspase-3 activation Antioxidants & Redox Signaling 9/15/2010 [PMID: 20136500]
• Mehdi Shakibaei, Bokyung Sung, Gautam Sethi, Bharat B. Aggarwal TNF-alpha-induced mitochondrial alterations in human T cells requires FADD and caspase-8 activation but not RIP and caspase-3 activation Antioxidants & Redox Signaling 2010-09-15 [PMID: 20136500] (Western Blot, Human)
• Judith Sendzik, Mehdi Shakibaei, Monika Schäfer-Korting, Hartmut Lode, Ralf Stahlmann Synergistic effects of dexamethasone and quinolones on human-derived tendon cells International Journal of Antimicrobial Agents 4/1/2010 [PMID: 20034766]
• Khaleque Newaz Khan, Michio Kitajima, Koichi Hiraki, Akira Fujishita, Ichiro Sekine, Tadayuki Ishimaru et al. Changes in tissue inflammation, angiogenesis and apoptosis in endometriosis, adenomyosis and uterine myoma after GnRH agonist therapy Human Reproduction 3/1/2010 [PMID: 20008888]
• Phong Trang, Pedro P. Medina, Jason F. Wiggins, Lynnsie Ruffino, Kevin Kelnar, Michael Omotola et al. Regression of murine lung tumors by the let-7 microRNA Oncogene 3/18/2010 [PMID: 19966857]
• Niessen K, Zhang G, Ridgway JB, Chen H, Yan M ALK1 signaling regulates early postnatal lymphatic vessel development. Blood, 2009-11-10;115(8):1654-61. 2009-11-10 [PMID: 19903896] (IHC, Mouse)
• Yawno T, Hirst JJ, Castillo-Melendez M, Walker DW Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain. Neuroscience, 2009-07-08;163(3):838-47. 2009-07-08 [PMID: 19591903] (IHC-P, Ovine)
• Fischer AJ, Scott MA, Ritchey ER, Sherwood P Mitogen-activated protein kinase-signaling regulates the ability of Muller glia to proliferate and protect retinal neurons against excitotoxicity. Glia, 2009-11-01;57(14):1538-52. 2009-11-01 [PMID: 19306360] (IHC-Fr, Chicken)
• Borchers MT, Wesselkamper SC, Curull V, Ramirez-Sarmiento A, Sanchez-Font A, Garcia-Aymerich J, Coronell C, Lloreta J, Agusti AG, Gea J, Howington JA, Reed MF, Starnes SL, Harris NL, Vitucci M, Eppert BL, Motz GT, Fogel K, McGraw DW, Tichelaar JW, Orozco-Levi M Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease. J. Clin. Invest., 2009-02-09;119(3):636-49. 2009-02-09 [PMID: 19197141] (IHC-P, Mouse)
• Stedman A, Lecaudey V, Havis E, Anselme I, Wassef M, Gilardi-Hebenstreit P, Schneider-Maunoury S A functional interaction between Irx and Meis patterns the anterior hindbrain and activates krox20 expression in rhombomere 3. Dev. Biol., 2008-12-25;327(2):566-77. 2008-12-25 [PMID: 19152797] (IHC, Zebrafish)
• Sozo F, O'Day L, Maritz G, Kenna K, Stacy V, Brew N, Walker D, Bocking A, Brien J, Harding R Repeated ethanol exposure during late gestation alters the maturation and innate immune status of the ovine fetal lung. Am. J. Physiol. Lung Cell Mol. Physiol., 2008-12-26;296(3):L510-8. 2008-12-26 [PMID: 19112099] (IHC-P, Ovine)
• Michaelis M, Bliss J, Arnold SC, Hinsch N, Rothweiler F, Deubzer HE, Witt O, Langer K, Doerr HW, Wels WS, Cinatl J Cisplatin-resistant neuroblastoma cells express enhanced levels of epidermal growth factor receptor (EGFR) and are sensitive to treatment with EGFR-specific toxins. Clin. Cancer Res., 2008-10-15;14(20):6531-7. 2008-10-15 [PMID: 18927293] (ICC, Human)
• Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Yla-Herttuala S, Wedge SR, Jurgensmeier JM, Alitalo K The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis. Cancer Res., 2008-06-15;68(12):4754-62. 2008-06-15 [PMID: 18559522] (ICC, Human)
• Boncoeur E, Roque T, Bonvin E, Saint-Criq V, Bonora M, Clement A, Tabary O, Henrion-Caude A, Jacquot J Cystic fibrosis transmembrane conductance regulator controls lung proteasomal degradation and nuclear factor-kappaB activity in conditions of oxidative stress. Am. J. Pathol., 2008-03-27;172(5):1184-94. 2008-03-27 [PMID: 18372427] (IHC-P, Mouse)
• Siegl-Cachedenier I, Flores I, Klatt P, Blasco MA Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres. J. Cell Biol., 2007-10-22;179(2):277-90. 2007-10-22 [PMID: 17954610] (IHC-P, Mouse)
• Benosman S, Gross I, Clarke N, Jochemsen AG, Okamoto K, Loeffler JP, Gaiddon C Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis. Cell Death Differ., 2007-09-07;14(12):2047-57. 2007-09-07 [PMID: 17823617] (ICC, Mouse)
• Bond JA, Gescher AJ, Verschoyle RD, Lemoine NR, Errington R, Wiltshire M, Smith PJ, Wynford-Thomas D Cytotoxic action of phorbol esters on human pancreatic cancer cells. Int. J. Cancer, 2007-10-01;121(7):1445-54. 2007-10-01 [PMID: 17582609] (ICC, Human)
• Wu F, Chiocca S, Beck WT, Mo YY Gam1-associated alterations of drug responsiveness through activation of apoptosis. Mol. Cancer Ther., 2007-06-01;6(6):1823-30. 2007-06-01 [PMID: 17575111] (ICC, Human)
• Yawno T, Yan EB, Walker DW, Hirst JJ Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep. Neuroscience, 2007-04-20;146(4):1726-33. 2007-04-20 [PMID: 17449186] (IHC-P, Ovine)
• Blouw B, Haase VH, Song H, Bergers G, Johnson RS Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene. Oncogene, 2007-02-05;26(31):4531-40. 2007-02-05 [PMID: 17297464] (IHC, Mouse)
• Xue M, Campbell D, Jackson CJ Protein C is an autocrine growth factor for human skin keratinocytes. J. Biol. Chem., 2007-02-09;282(18):13610-6. 2007-02-09 [PMID: 17293597] (Western Blot, Human)
• do Vale A, Costa-Ramos C, Silva DS, Macedo PM, Fernandes R, Sampaio P, Dos Santos NM, Silva MT Cytochemical and ultrastructural study of anoikis and secondary necrosis in enterocytes detached in vivo. Apoptosis, 2007-06-01;12(6):1069-83. 2007-06-01 [PMID: 17245641] (IHC-P, Fish)
• Fessing MY, Sharova TY, Sharov AA, Atoyan R, Botchkarev VA Involvement of the Edar signaling in the control of hair follicle involution (catagen). Am. J. Pathol., 2006-12-01;169(6):2075-84. 2006-12-01 [PMID: 17148670] (IHC-Fr, Mouse)
• Blanpain C, Lowry WE, Pasolli HA, Fuchs E Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev., 2006-11-01;20(21):3022-35. 2006-11-01 [PMID: 17079689] (IHC, Mouse)
• Harris LK, Keogh RJ, Wareing M, Baker PN, Cartwright JE, Aplin JD, Whitley GS Invasive trophoblasts stimulate vascular smooth muscle cell apoptosis by a fas ligand-dependent mechanism. Am. J. Pathol., 2006-11-01;169(5):1863-74. 2006-11-01 [PMID: 17071607] (IHC-Fr, Human)
• Rodriguez-Guzman M, Montero JA, Santesteban E, Ganan Y, Macias D, Hurle JM Tendon-muscle crosstalk controls muscle bellies morphogenesis, which is mediated by cell death and retinoic acid signaling. Dev. Biol., 2006-09-26;302(1):267-80. 2006-09-26 [PMID: 17070795] (IHC, Chicken)
• Hendriksen PJ, Dits NF, Kokame K, Veldhoven A, van Weerden WM, Bangma CH, Trapman J, Jenster G Evolution of the androgen receptor pathway during progression of prostate cancer. Cancer Res., 2006-05-15;66(10):5012-20. 2006-05-15 [PMID: 16707422] (ICC, Human)
• Kossmehl P, Kurth E, Faramarzi S, Habighorst B, Shakibaei M, Wehland M, Kreutz R, Infanger M, J Danser AH, Grosse J, Paul M, Grimm D Mechanisms of apoptosis after ischemia and reperfusion: role of the renin-angiotensin system. Apoptosis, 2006-03-01;11(3):347-58. 2006-03-01 [PMID: 16538381] (Western Blot, Porcine)
• Jacomy H, Fragoso G, Almazan G, Mushynski WE, Talbot PJ Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice. Virology, 2006-03-09;349(2):335-46. 2006-03-09 [PMID: 16527322] (ICC, Mouse)
• Ohyama T, Mohamed OA, Taketo MM, Dufort D, Groves AK Wnt signals mediate a fate decision between otic placode and epidermis. Development, 2006-02-01;133(5):865-75. 2006-02-01 [PMID: 16452098] (IHC, Mouse)
• Grzmil M, Kaulfuss S, Thelen P, Hemmerlein B, Schweyer S, Obenauer S, Kang TW, Burfeind P Expression and functional analysis of Bax inhibitor-1 in human breast cancer cells. J. Pathol., 2006-02-01;208(3):340-9. 2006-02-01 [PMID: 16353131] (ICC, Human)
• De Bock M, Decostere A, Hellemans A, Haesebrouck F, Ducatelle R Helicobacter felis and Helicobacter bizzozeronii induce gastric parietal cell loss in Mongolian gerbils. Microbes Infect., 2005-10-11;8(2):503-10. 2005-10-11 [PMID: 16311055] (IHC, Mouse)
• Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noel A, Cataldo DD Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J. Immunol., 2005-08-15;175(4):2589-97. 2005-08-15 [PMID: 16081833] (IHC-P, Mouse)
• Naoto Kawakami, U. Valentin Nägerl, Francesca Odoardi, Tobias Bonhoeffer, Hartmut Wekerle, Alexander Flügel Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion The Journal of Experimental Medicine 6/6/2005 [PMID: 15939794]
• Geenen K, Favoreel HW, Nauwynck HJ Higher resistance of porcine trigeminal ganglion neurons towards pseudorabies virus-induced cell death compared with other porcine cell types in vitro. J. Gen. Virol., 2005-05-01;86(0):1251-60. 2005-05-01 [PMID: 15831935] (ICC, Porcine)
• Schlott T, Taubert H, Fayyazi A, Schweyer S, Bartel F, Korabiowska M, Brinck U Analysis of central regulatory pathways in p53-deficient primary cultures of malignant fibrous histiocytoma exposed to ifosfamide. Anticancer Res., 2004-11-01;24(6):3819-29. 2004-11-01 [PMID: 15736417] (ICC, Human)
• Glamoclija V, Vilovic K, Saraga-Babic M, Baranovic A, Sapunar D Apoptosis and active caspase-3 expression in human granulosa cells. Fertil. Steril., 2005-02-01;83(2):426-31. 2005-02-01 [PMID: 15705385] (ICC, IHC-P, Human)
• Kuo LT, Simpson A, Schanzer A, Tse J, An SF, Scaravilli F, Groves MJ Effects of systemically administered NT-3 on sensory neuron loss and nestin expression following axotomy. J. Comp. Neurol., 2005-02-21;482(4):320-32. 2005-02-21 [PMID: 15669078] (ICC, Rat)
• Salomonsson S, Sonesson SE, Ottosson L, Muhallab S, Olsson T, Sunnerhagen M, Kuchroo VK, Thoren P, Herlenius E, Wahren-Herlenius M Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block. J. Exp. Med., 2005-01-03;201(1):11-7. 2005-01-03 [PMID: 15630133] (ICC, Rat)
• Geenen K, Favoreel HW, Olsen L, Enquist LW, Nauwynck HJ The pseudorabies virus US3 protein kinase possesses anti-apoptotic activity that protects cells from apoptosis during infection and after treatment with sorbitol or staurosporine. Virology, 2005-01-05;331(1):144-50. 2005-01-05 [PMID: 15582661] (ICC, Porcine)
• Zitterkopf NL, McNeal DW, Eyster KM, Bradley DS, Cafruny WA Lactate dehydrogenase-elevating virus induces apoptosis in cultured macrophages and in spinal cords of C58 mice coincident with onset of murine amyotrophic lateral sclerosis. Virus Res., 2004-11-01;106(1):35-42. 2004-11-01 [PMID: 15522445] (ICC, IHC-Fr, Mouse)
• Niquet J, Allen SG, Baldwin RA, Wasterlain CG Evidence of caspase-3 activation in hyposmotic stress-induced necrosis. Neurosci. Lett., 2004-02-19;356(3):225-7. 2004-02-19 [PMID: 15036635] (ICC, Rat)
• Grzmil M, Hemmerlein B, Thelen P, Schweyer S, Burfeind P Blockade of the type I IGF receptor expression in human prostate cancer cells inhibits proliferation and invasion, up-regulates IGF binding protein-3, and suppresses MMP-2 expression. J. Pathol., 2004-01-01;202(1):50-9. 2004-01-01 [PMID: 14694521] (ICC, Human, Mouse)
• Wang P, Valentijn AJ, Gilmore AP, Streuli CH Early events in the anoikis program occur in the absence of caspase activation. J. Biol. Chem., 2003-03-05;278(22):19917-25. 2003-03-05 [PMID: 12621032] (ICC, Mouse)

Reviews for Caspase-3 Antibody (AF835) (7)

Average Rating: 4.9

(Based on 7 reviews)

We have 7 reviews tested in 2 species: Mouse, Other.

reviewed by: Verified Customer WB Mouse 01/09/2015

Summary

• Application: Western Blot
• Sample Tested: See PMID 23374352
• Species: Mouse

reviewed by: Verified Customer IHC-P Mouse 01/09/2015

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: See PMID 20522641
• Species: Mouse

reviewed by: Verified Customer IHC-P Mouse 01/09/2015

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: See PMID 22897852
• Species: Mouse

reviewed by: Verified Customer IHC-P Other 01/09/2015

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: See PMID 22438018
• Species: Other

reviewed by: Verified Customer IF Mouse 01/09/2015

Summary

• Application: Immunofluorescence
• Sample Tested: See PMID 23532769
• Species: Mouse

reviewed by: Verified Customer IF Mouse 01/09/2015

Summary

• Application: Immunofluorescence
• Sample Tested: See PMID 19226508
• Species: Mouse

reviewed by: Verified Customer IHC-P Mouse 01/09/2015

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: See PMID 23742999
• Species: Mouse

Bioinformatics

• Gene Symbol: CASP3
• Uniprot:
  • P42574(Rabbit)