Caspase-3 Antibody [Unconjugated] - Active

Caspase‑3 was detected in immersion fixed anti-FAS treated Jurkat human acute T cell leukemia cell line using 0.3 µg/mL Human/Mouse Active Caspase‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) for 3 hours at room temperature. Cells were stained (red) and counterstained (green). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Caspase‑3 was detected in immersion fixed Jurkat human acute T cell leukemia cell line stimulated with staurosporin using Human/Mouse Active Caspase‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Rabbit IgG Secondary Antibody (yellow; Catalog # NL004) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Caspase‑3 was detected in immersion fixed paraffin-embedded sections of human colon cancer tissue using Rabbit Anti-Human/Mouse Active Caspase‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) at 1 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Rabbit IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC003). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

• Reactivity: Hu, Mu
• Applications: IHC, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: LYOPH

Caspase-3 Antibody [Unconjugated] - Active Summary

• Immunogen: KLH-coupled human Caspase-3 synthetic peptide
  CRGTELDCGIETD
  Accession # P42574
• Specificity: Distinguishes apoptotic cells from non-apoptotic cells in immunohistochemistry. Detects the p17 subunit of Caspase-3, but does not detect the precursor form in Western blot. We recommend R&D Systems Affinity Purified Anti-Caspase-3 (Catalog # AF-605-NA) or Monoclonal Anti-Cleaved-Caspase-3 (Catalog # MAB835) for Western blot applications.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CASP3
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry 5-15 ug/mL
  • Immunohistochemistry 1-15 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Caspase-3 Antibody [Unconjugated] - Active

• Apopain
• apoptosis-related cysteine protease
• CASP3
• CASP-3
• caspase 3, apoptosis-related cysteine peptidase
• Caspase3
• Caspase-3
• CPP32
• CPP-32
• CPP32B
• CPP32SREBP cleavage activity 1
• Cysteine protease CPP32
• EC 3.4.22
• EC 3.4.22.56
• LICE-1
• PARP cleavage protease
• procaspase3
• Protein Yama
• SCA-1
• YAMA

Background

Caspase-3 (Cysteine-aspartic acid protease 3/Casp3; also Yama, apopain and CPP32) is a 29 kDa heterodimer that belongs to the peptidase C14A family of enzymes. It is widely expressed, and considered to be the major executioner caspase in the apoptotic cascade. Human procaspase-3 is a 32 kDa, 277 amino acid (aa) protein and is normally an inactive homodimer. Following cell stress/activation, procaspase-3 undergoes proteolysis to generate an N-terminal 148 aa p17/17 kDa subunit (aa 29-175), plus a 102 aa C-terminal p12/12 kDa subunit. These subunits noncovalently heterodimerize, and associate with another p17/p12 heterodimer to form an active enzyme. There is one potential variant that shows an alternative start site nine aa upstream of the standard start site coupled with a 21 aa substitution for aa 162-277. Over aa 29-175, human and mouse caspase-3 share 87% aa identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Caspase-3 Antibody (AF835)(202)

Publications using AF835

• Congiu, L;Granato, V;Jakovcevski, I;Kleene, R;Fernandes, L;Freitag, S;Kneussel, M;Schachner, M;Loers, G; Mice Mutated in the Third Fibronectin Domain of L1 Show Enhanced Hippocampal Neuronal Cell Death, Astrogliosis and Alterations in Behavior Biomolecules 2023-04-29 [PMID: 37238646] (IHC, Mouse)
• Kelly, SB;Dean, JM;Zahra, VA;Dudink, I;Thiel, A;Polglase, GR;Miller, SL;Hooper, SB;Bennet, L;Gunn, AJ;Galinsky, R; Progressive inflammation reduces high-frequency EEG activity and cortical dendritic arborisation in late gestation fetal sheep Journal of neuroinflammation 2023-05-24 [PMID: 37226206] (IHC, Ovine)
• L Provitera, A Tomaselli, G Raffaeli, S Crippa, C Arribas, I Amodeo, S Gulden, GS Amelio, V Cortesi, F Manzoni, G Cervellini, J Cerasani, C Menis, N Pesenti, M Tripodi, L Santi, M Maggioni, C Lonati, S Oldoni, F Algieri, F Garrido, ME Bernardo, F Mosca, G Cavallaro Human Bone Marrow-Derived Mesenchymal Stromal Cells Reduce the Severity of Experimental Necrotizing Enterocolitis in a Concentration-Dependent Manner Cells, 2023-02-27;12(5):. 2023-02-27 [PMID: 36899900] (IHC, Mouse)
• P Martino, R Sunkara, N Heitman, M Rangl, A Brown, N Saxena, L Grisanti, D Kohan, M Yanagisawa, M Rendl Progenitor-derived endothelin controls dermal sheath contraction for hair follicle regression Nature Cell Biology, 2023-01-30;0(0):. 2023-01-30 [PMID: 36717629] (IHC, Mouse)
• D Piekna-Prz, D Na, J Zhang, C Baker, JM Ashton, PM White Single cell RNA sequencing analysis of mouse cochlear supporting cell transcriptomes with activated ERBB2 receptor indicates a cell-specific response that promotes CD44 activation Frontiers in Cellular Neuroscience, 2023-01-06;16(0):1096872. 2023-01-06 [PMID: 36687526] (ICC, Mouse)
• G Ortiz-Álva, A Fortoul, A Srivastava, MX Moreau, B Bouloudi, C Mailhes-Ha, N Delgehyr, M Faucourt, M Bahin, C Blugeon, M Breau, V Géli, F Causeret, A Meunier, N Spassky p53/p21 pathway activation contributes to the ependymal fate decision downstream of GemC1 Cell Reports, 2022-12-13;41(11):111810. 2022-12-13 [PMID: 36516767] (IHC, Mouse)
• SS Karshieva, EG Glinskaya, AA Dalina, EV Akhlyustin, EA Makarova, YD Khesuani, NS Chmelyuk, MA Abakumov, DA Khochenkov, VA Mironov, GA Meerovich, EA Kogan, EV Koudan Antitumor activity of photodynamic therapy with tetracationic derivative of synthetic bacteriochlorin in spheroid culture of liver and colon cancer cells Photodiagnosis and photodynamic therapy, 2022-11-15;0(0):103202. 2022-11-15 [PMID: 36400167] (IHC, Human)
• M García-Pug, A Saenz-Anto, G Gerenu, A Arrieta, R Fernandez-, M Zulaica, A Saenz, J Elizazu, G Nogales-Ga, SM Gadalla, MJ Araúzo-Bra, A Lopez de M, A Matheu Senescence plays a role in Myotonic Dystrophy type 1 JCI Insight, 2022-10-10;0(0):. 2022-10-10 [PMID: 36040809] (Flow Cytometry, Mouse)
• EG Vasquez, N Nasreddin, GN Valbuena, EJ Mulholland, HL Belnoue-Da, HR Eggington, RO Schenck, VM Wouters, P Wirapati, K Gilroy, TRM Lannagan, DJ Flanagan, AK Najumudeen, S Omwenga, AMB McCorry, A Easton, VH Koelzer, JE East, D Morton, L Trusolino, T Maughan, AD Campbell, MB Loughrey, PD Dunne, P Tsantoulis, DJ Huels, S Tejpar, OJ Sansom, SJ Leedham Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia Cell Stem Cell, 2022-08-04;29(8):1213-1228.e8. 2022-08-04 [PMID: 35931031] (IHC, Mouse)
• T Imai, TM Van, M Pasparakis, A Polykratis Smooth muscle cell specific NEMO deficiency inhibits atherosclerosis in ApoE-/- mice Scientific Reports, 2022-07-22;12(1):12538. 2022-07-22 [PMID: 35869246] (IHC, Mouse)
• AE Hall, SÖ Pohl, P Cammareri, S Aitken, NT Younger, M Raponi, CV Billard, AB Carrancio, A Bastem, P Freile, F Haward, IR Adams, JF Caceres, P Preyzner, A von Kriegs, MG Dunlop, FV Din, KB Myant RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer Nature Communications, 2022-05-19;13(1):2791. 2022-05-19 [PMID: 35589755] (IHC, Mouse)
• RJ Krawetz, YE Wu, KL Bertram, A Shonak, AO Masson, G Ren, C Leonard, M Kapoor, JR Matyas, PT Salo Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity Cell Death & Disease, 2022-05-18;13(5):470. 2022-05-18 [PMID: 35585042] (IHC, Human, Mouse)
• R Belgacemi, S Danopoulos, G Deutsch, I Glass, V Dormoy, S Bellusci, D Al Alam Hedgehog Signaling Pathway Orchestrates Human Lung Branching Morphogenesis International Journal of Molecular Sciences, 2022-05-09;23(9):. 2022-05-09 [PMID: 35563656] (IHC, Human)
• P Yamkate, JA Lidbury, JM Steiner, JS Suchodolsk, PR Giaretta Immunohistochemical Expression of Oxidative Stress and Apoptosis Markers in Archived Liver Specimens from Dogs with Chronic Hepatitis Journal of comparative pathology, 2022-04-01;193(0):25-36. 2022-04-01 [PMID: 35487620] (IHC, Canine)
• H Wen, X Zhang, Q Li, J Huang, G Liu, J Zhao, Y Liu, L Shen, Y Li, K Yang, L Zuo, J Li, J Nian, P Xiang, H Zhao, L Yu, M Liu, Z Geng, X Song Ruscogenins Improve CD-Like Enteritis by Inhibiting Apoptosis of Intestinal Epithelial Cells and Activating Nrf2/NQO1 Pathway Oxidative Medicine and Cellular Longevity, 2022-03-10;2022(0):4877275. 2022-03-10 [PMID: 35308175] (ICC/IF, Mouse)
• C Lee, J Kim, J Han, D Oh, M Kim, H Jeong, TJ Kim, SW Kim, JN Kim, YS Seo, A Suzuki, JH Kim, Y Jung Formyl peptide receptor 2 determines sex-specific differences in the progression of nonalcoholic fatty liver disease and steatohepatitis Nature Communications, 2022-01-31;13(1):578. 2022-01-31 [PMID: 35102146] (IHC, Mouse)
• S André, M Picard, R Cezar, F Roux-Dalva, A Alleaume-B, C Soundaramo, AS Cruz, A Mendes-Fri, C Gotti, M Leclercq, A Nicolas, A Tauzin, A Carvalho, C Capela, J Pedrosa, AG Castro, L Kundura, P Loubet, A Sotto, L Muller, JY Lefrant, C Roger, PG Claret, S Duvnjak, TA Tran, G Racine, O Zghidi-Abo, P Nioche, R Silvestre, A Droit, F Mammano, P Corbeau, J Estaquier T cell apoptosis characterizes severe Covid-19 disease Cell Death and Differentiation, 2022-01-22;0(0):. 2022-01-22 [PMID: 35066575] (ICC, Human)
• D Chen, ED Hughes, TL Saunders, J Wu, MN Hernández, T Makinen, PD King Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells JCI Insight, 2022-02-22;0(0):. 2022-02-22 [PMID: 35015735] (IHC, Mouse)
• J Schreiber, N Liaukouska, L Fuhrmann, AT Hauser, M Jung, TB Huber, N Wanner BET Proteins Regulate Expression of Osr1 in Early Kidney Development Biomedicines, 2021-12-10;9(12):. 2021-12-10 [PMID: 34944697] (ICC, Mouse)
• P Flora, MY Li, PM Galbo, M Astorkia, D Zheng, E Ezhkova Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration PloS Genetics, 2021-12-14;17(12):e1009948. 2021-12-14 [PMID: 34905545] (IHC, Transgenic Mouse)
• B Schwarze, A Korn, C Höfling, U Zeitschel, M Krueger, S Ro beta ner, D Huster Peptide backbone modifications of amyloid beta (1-40) impact fibrillation behavior and neuronal toxicity Scientific Reports, 2021-12-09;11(1):23767. 2021-12-09 [PMID: 34887476] (ICC, Mouse)
• W Nakajima, S Nakanishi, R Hosoya, T Uemoto, S Ohgo, N Wada Regenerative Polarity of the Fin Ray in Zebrafish Caudal Fin and Related Tissue Formation on the Cut Surface Journal of developmental biology, 2021-11-19;9(4):. 2021-11-19 [PMID: 34842743] (IHC, Zebrafish)
• M Dottermusc, P Sumis?awsk, J Krevet, M Middelkamp, H Vo beta , B Siebels, H Bartsch, K Sotlar, P Meyer, S Frank, A Korshunov, M Glatzel, U Schüller, JE Neumann Co-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma Oncogenesis, 2021-11-16;10(11):78. 2021-11-16 [PMID: 34785636] (IHC, Mouse)
• S Shi, MMA Verstegen, HP Roest, AI Ardisasmit, W Cao, FJM Roos, PE de Ruiter, M Niemeijer, Q Pan, JNM IJzermans, LJW van der La Recapitulating cholangiopathy-associated necroptotic cell death in vitro using human cholangiocyte organoids Cellular and Molecular Gastroenterology and Hepatology, 2021-10-23;0(0):. 2021-10-23 [PMID: 34700031] (IF, Human)
• C Junqueira, R Dariolli, J Haydak, S Kang, T Hannah, RJ Wiener, S DeFronzo, R Tejero, GL Gusella, A Ramakrishn, R Alves Dias, A Wojcinski, S Kesari, L Shen, EA Sobie, JP Rodrigues, EU Azeloglu, H Zou, RH Friedel Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion Nature Communications, 2021-10-14;12(1):6019. 2021-10-14 [PMID: 34650052] (ICC, Human)
• EJ Ruiz, A Pinto-Fern, AP Turnbull, L Lan, TM Charlton, HC Scott, A Damianou, G Vere, EM Riising, C Da Costa, WW Krajewski, D Guerin, JD Kearns, S Ioannidis, M Katz, C McKinnon, J O'Connell, N Moncaut, I Rosewell, E Nye, N Jones, C Heride, M Gersch, M Wu, CJ Dinsmore, TR Hammonds, S Kim, D Komander, S Urbe, MJ Clague, BM Kessler, A Behrens USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma Elife, 2021-10-12;10(0):. 2021-10-12 [PMID: 34636321] (IHC, Mouse)
• F Harnischfe, F O'Connell, M Weiss, B Axelrod, A Hajnal, K Czaja, PM Di Lorenzo, R Dando Sprague Dawley Rats Gaining Weight on a High Energy Diet Exhibit Damage to Taste Tissue Even after Return to a Healthy Diet Nutrients, 2021-08-31;13(9):. 2021-08-31 [PMID: 34578940] (IHC, Rat)
• A Soni, D Klütsch, X Hu, J Houtman, N Rund, A McCloskey, J Mertens, ST Schafer, H Amin, T Toda Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells Cells, 2021-07-26;10(8):. 2021-07-26 [PMID: 34440662] (ICC, Mouse)
• N Mary, A Calgaro, H Barasc, N Bonnet, S Ferchaud, I Raymond-Le, A Ducos, A Pinton Meiotic Silencing in Pigs: A Case Study in a Translocated Azoospermic Boar Genes, 2021-07-27;12(8):. 2021-07-27 [PMID: 34440311] (IHC, Porcine)
• HM Schmitt, RL Fehrman, ME Maes, H Yang, LW Guo, CL Schlamp, HR Pelzel, RW Nickells Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression Investigative Ophthalmology & Visual Science, 2021-08-02;62(10):14. 2021-08-02 [PMID: 34398198] (IHC, Mouse)
• D Pradella, G Deflorian, A Pezzotta, A Di Matteo, E Belloni, D Campolungo, A Paradisi, M Bugatti, W Vermi, M Campioni, A Chiapparin, L Scietti, F Forneris, C Giampietro, N Volf, M Rehman, S Zacchigna, MP Paronetto, A Pistocchi, A Eichmann, P Mehlen, C Ghigna A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis Nature Communications, 2021-08-11;12(1):4872. 2021-08-11 [PMID: 34381052] (IHC, Human)
• TR Penny, Y Pham, AE Sutherland, J Lee, G Jenkin, MC Fahey, SL Miller, CA McDonald Umbilical cord blood therapy modulates neonatal hypoxic ischemic brain injury in both females and males Scientific Reports, 2021-08-04;11(1):15788. 2021-08-04 [PMID: 34349144] (IHC, Rat)
• C Buhrmann, A Brockmuell, AL Mueller, P Shayan, M Shakibaei Curcumin Attenuates Environment-Derived Osteoarthritis by Sox9/NF-kB Signaling Axis International Journal of Molecular Sciences, 2021-07-16;22(14):. 2021-07-16 [PMID: 34299264] (ICC, Immunoprecipitation, Western Blot, Human)
• C Buhrmann, A Brockmuell, C Harsha, AB Kunnumakka, P Kubatka, BB Aggarwal, M Shakibaei Evidence That Tumor Microenvironment Initiates Epithelial-To-Mesenchymal Transition and Calebin A can Suppress it in Colorectal Cancer Cells Frontiers in Pharmacology, 2021-07-02;12(0):699842. 2021-07-02 [PMID: 34276382] (ICC, Western Blot, Human)
• ML Wegscheid, C Anastasaki, KA Hartigan, OM Cobb, JB Papke, JN Traber, SM Morris, DH Gutmann Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis Cell Reports, 2021-07-06;36(1):109315. 2021-07-06 [PMID: 34233200] (IHC, Human)
• H Nakashima, K Tsujimura, K Irie, T Imamura, CA Trujillo, M Ishizu, M Uesaka, M Pan, H Noguchi, K Okada, K Aoyagi, T Andoh-Noda, H Okano, AR Muotri, K Nakashima MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling Cell Reports, 2021-05-18;35(7):109124. 2021-05-18 [PMID: 34010654] (ICC, Human, Mouse)
• T Ingwersen, C Linnenberg, E D'Acunto, S Temori, I Paolucci, D Wasilewski, B Mohammadi, J Kirchmair, RC Glen, E Miranda, M Glatzel, G Galliciott G392E neuroserpin causing the dementia FENIB is secreted from cells but is not synaptotoxic Scientific Reports, 2021-04-22;11(1):8766. 2021-04-22 [PMID: 33888787] (ICC, IHC, Mouse)
• MT Dang, MV Gonzalez, KS Gaonkar, KS Rathi, P Young, S Arif, L Zhai, Z Alam, S Devalaraja, TKJ To, IW Folkert, P Raman, JL Rokita, D Martinez, JN Taroni, JA Shapiro, CS Greene, C Savonen, F Mafra, H Hakonarson, T Curran, M Haldar Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality Cell Reports, 2021-03-30;34(13):108917. 2021-03-30 [PMID: 33789113] (IHC, Mouse)
• M Recasens, B Almolda, J Pérez-Clau, IL Campbell, B González, B Castellano Chronic exposure to IL-6 induces a desensitized phenotype of the microglia Journal of Neuroinflammation, 2021-01-22;18(1):31. 2021-01-22 [PMID: 33482848] (IHC, Mouse)
• M Tajan, M Hennequart, EC Cheung, F Zani, AK Hock, N Legrave, ODK Maddocks, RA Ridgway, D Athineos, A Suárez-Bon, RL Ludwig, L Novellasde, N Angelis, VSW Li, G Vlachogian, N Valeri, N Mainolfi, V Suri, A Friedman, M Manfredi, K Blyth, OJ Sansom, KH Vousden Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy Nature Communications, 2021-01-14;12(1):366. 2021-01-14 [PMID: 33446657] (IHC, Mouse)
• S Titus, KJ Szymanska, B Musul, V Turan, E Taylan, R Garcia-Mil, S Mehta, K Oktay Individual-oocyte transcriptomic analysis shows that genotoxic chemotherapy depletes human primordial follicle reserve�in vivo by triggering proapoptotic pathways without growth activation Scientific Reports, 2021-01-11;11(1):407. 2021-01-11 [PMID: 33431979] (IHC, Human)
• KM Schukken, Y Zhu, PL Bakker, MH Koster, L Harkema, SA Youssef, A de Bruin, F Foijer Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice Scientific Reports, 2021-01-08;11(1):68. 2021-01-08 [PMID: 33420244] (IHC, Mouse)
• DH Yeom, YS Lee, I Ryu, S Lee, B Sung, HB Lee, D Kim, JH Ahn, E Ha, YS Choi, SH Lee, WK You ABL001, a Bispecific Antibody Targeting VEGF and DLL4, with Chemotherapy, Synergistically Inhibits Tumor Progression in Xenograft Models International Journal of Molecular Sciences, 2020-12-29;22(1):. 2020-12-29 [PMID: 33383646] (IHC, Mouse)
• MM Menger, P Bremer, C Scheuer, MF Rollmann, BJ Braun, SC Herath, M Orth, T Später, T Pohlemann, MD Menger, T Histing Pantoprazole impairs fracture healing in aged mice Scientific Reports, 2020-12-23;10(1):22376. 2020-12-23 [PMID: 33361800] (Western Blot, Mouse)
• Y Arioka, E Shishido, I Kushima, T Suzuki, R Saito, A Aiba, D Mori, N Ozaki Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons EBioMedicine, 2020-12-17;63(0):103138. 2020-12-17 [PMID: 33341442] (ICC, Human)
• J Choi, DH Lee, H Jang, SY Park, JW Seol Naringenin exerts anticancer effects by inducing tumor cell death and inhibiting angiogenesis in malignant melanoma International Journal of Medical Sciences, 2020-10-18;17(18):3049-3057. 2020-10-18 [PMID: 33173425] (ICC, Mouse)
• B Di Marco, EE Crouch, B Shah, C Duman, MF Paredes, C Ruiz de Al, EJ Huang, J Alfonso Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon Cell Rep, 2020-10-13;33(2):108256. 2020-10-13 [PMID: 33053356] (IHC, Mouse)
• S Funcke, TR Werner, M Hein, BM Ulmer, A Hansen, T Eschenhage, MN Hirt Effects of the Delta Opioid Receptor Agonist DADLE in a Novel Hypoxia-Reoxygenation Model on Human and Rat-Engineered Heart Tissue: A Pilot Study Biomolecules, 2020-09-11;10(9):. 2020-09-11 [PMID: 32932811] (IHC, Rat)
• MJ Nokin, E Darbo, C Travert, B Drogat, A Lacouture, S San José, N Cabrera, B Turcq, V Prouzet-Ma, M Falcone, A Villanueva, H Wang, M Herfs, M Mosteiro, PA Jänne, JL Pujol, A Maraver, M Barbacid, E Nadal, D Santamaría, C Ambrogio Inhibition of DDR1 enhances in vivo chemosensitivity in KRAS-mutant lung adenocarcinoma JCI Insight, 2020-08-06;5(15):. 2020-08-06 [PMID: 32759499] (IHC, Mouse)
• J Auzmendi-I, A Saenz-Anto, I Mikelez-Al, E Carrasco-G, M Tellaetxe-, CH Lawrie, N Sampron, AL Cortajaren, A Matheu Characterization of a new small-molecule inhibitor of HDAC6 in glioblastoma Cell Death Dis, 2020-06-02;11(6):417. 2020-06-02 [PMID: 32488056] (IHC, Human)
• F Chang, SJ Kong, L Wang, BK Choi, H Lee, C Kim, JM Kim, K Park Targeting Actomyosin Contractility Suppresses Malignant Phenotypes of Acute Myeloid Leukemia Cells Int J Mol Sci, 2020-05-14;21(10):. 2020-05-14 [PMID: 32422910] (IHC, Mouse)
• J Aldaregia, P Errarte, A Olazagoiti, M Gimeno, JJ Uriz, TR Gershon, I Garcia, A Matheu Erbb4 Is Required for Cerebellar Developmentand Malignant Phenotype of Medulloblastoma Cancers (Basel), 2020-04-17;12(4):. 2020-04-17 [PMID: 32316671] (ICC, IHC, Mouse)
• NJ Yates, KW Feindel, A Mehnert, R Beare, S Quick, D Blache, JJ Pillow, RW Hunt Ex Vivo MRI Analytical Methods and Brain Pathology in Preterm Lambs Treated with Postnatal Dexamethasone � Brain Sci, 2020-04-03;10(4):. 2020-04-03 [PMID: 32260193] (IHC, Lamb)
• MA Khan, T Shamma, S Kazmi, A Altuhami, HA Ahmed, AM Assiri, DC Broering Hypoxia-induced complement dysregulation is associated with microvascular impairments in mouse tracheal transplants J Transl Med, 2020-03-31;18(1):147. 2020-03-31 [PMID: 32234039] (IHC, Mouse)
• Z Ying, S Beronja Embryonic Barcoding of Equipotent Mammary Progenitors Functionally Identifies Breast Cancer Drivers Cell Stem Cell, 2020-02-13;0(0):. 2020-02-13 [PMID: 32059806] (IHC, Transgenic Mouse)
• P Aldaz, M Otaegi-Uga, A Saenz-Anto, M Garcia-Pug, M Moreno-Val, JM Flores, D Gerovska, MJ Arauzo-Bra, N Samprón, A Matheu, E Carrasco-G SOX9 promotes tumor progression through the axis BMI1-p21CIP Sci Rep, 2020-01-15;10(1):357. 2020-01-15 [PMID: 31941916] (IF, Human)
• A Malhotra, M Castillo-M, BJ Allison, AE Sutherland, I Nitsos, Y Pham, CA McDonald, MC Fahey, GR Polglase, G Jenkin, SL Miller Neurovascular effects of umbilical cord blood-derived stem cells in growth-restricted newborn lambs : UCBCs for perinatal brain injury Stem Cell Res Ther, 2020-01-08;11(1):17. 2020-01-08 [PMID: 31915068]
• K Boric, S Mardesic, D Martinovic, M Radic, I Tadin Hadj, K Vukojevic, I Kosovic, I Solic, S Zekic Toma, M Saraga-Bab Expression of apoptotic and proliferation factors in gastric mucosa of patients with systemic sclerosis correlates with form of the disease Sci Rep, 2019-12-05;9(1):18461. 2019-12-05 [PMID: 31804582] (IHC-P, Human)
• LG Jones, A Vaida, LM Thompson, FI Ikuomola, JH Caamaño, MD Burkitt, F Miyajima, JM Williams, BJ Campbell, DM Pritchard, CA Duckworth NF-kappaB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells Cell Death Dis, 2019-11-26;10(12):896. 2019-11-26 [PMID: 31772152] (IHC, Mouse)
• E Grall, V Gourain, A Naïr, E Martin, MC Birling, JN Freund, I Duluc Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs Cell Death Dis, 2019-10-24;10(11):812. 2019-10-24 [PMID: 31649239] (IHC-P, Mouse)
• F Jaudon, M Chiacchiar, M Albini, S Ferroni, F Benfenati, F Cesca Kidins220/ARMS controls astrocyte calcium signaling and neuron-astrocyte communication Cell Death Differ., 2019-10-17;27(5):1505-1519. 2019-10-17 [PMID: 31624352] (ICC, Human, Mouse)
• S Zhao, M Thakur, AW Klattenhof, D Kidane Aberrant DNA Polymerase Beta Enhances H. pylori Infection Induced Genomic Instability and Gastric Carcinogenesis in Mice Cancers (Basel), 2019-06-18;11(6):. 2019-06-18 [PMID: 31216714] (IHC, Mouse)
• D Aprile, F Fruscione, S Baldassari, M Fadda, D Ferrante, A Falace, E Buhler, J Sartorelli, A Represa, P Baldelli, F Benfenati, F Zara, A Fassio TBC1D24 regulates axonal outgrowth and membrane trafficking at the growth cone in rodent and human neurons Cell Death Differ., 2019-03-11;0(0):. 2019-03-11 [PMID: 30858606] (ICC, Rat)
• P Antas, L Novellasde, A Kucharska, I Massie, J Carvalho, D Oukrif, E Nye, M Novelli, VSW Li SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating ?-Catenin Nuclear Localization Cell Rep, 2019-02-26;26(9):2266-2273.e4. 2019-02-26 [PMID: 30811977] (IHC-P, Mouse)
• BA Brown, GM Connolly, CEJ Mill, H Williams, GD Angelini, JL Johnson, SJ George Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells Aging Cell, 2018-12-12;0(0):e12844. 2018-12-12 [PMID: 30548452] (ICC, Mouse)
• O Bover, T Justo, PNG Pereira, J Facucho-Ol, JM Inácio, JS Ramalho, IJ Domian, JA Belo Loss of Ccbe1 affects cardiac-specification and cardiomyocyte differentiation in mouse embryonic stem cells PLoS ONE, 2018-10-03;13(10):e0205108. 2018-10-03 [PMID: 30281646] (Flow Cytometry, Mouse)
• RK Zwick, MC Rudolph, BA Shook, B Holtrup, E Roth, V Lei, A Van Keymeu, V Seewaldt, S Kwei, J Wysolmersk, MS Rodeheffer, V Horsley Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation Nat Commun, 2018-09-04;9(1):3592. 2018-09-04 [PMID: 30181538] (IHC, Mouse)
• M Ouarné, C Bouvard, G Boneva, C Mallet, J Ribeiro, A Desroches-, E Soleilhac, E Tillet, O Peyruchaud, S Bailly BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer J. Exp. Clin. Cancer Res., 2018-08-30;37(1):209. 2018-08-30 [PMID: 30165893] (IHC-P, Mouse)
• A López-Muño, FE Nicolás, D García-Mor, AB Pérez-Oliv, MI Navarro-Me, MA Hernández-, A Herrera-Es, S Torres-Mar, RM Ruiz-Vázqu, V Garre, V Mulero An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages Sci Rep, 2018-08-24;8(1):12802. 2018-08-24 [PMID: 30143654] (IHC-P, Zebrafish)
• P Shen, J Chen, M Pan The protective effects of total paeony glycoside on ischemia/reperfusion injury in H9C2 cells via inhibition of the PI3K/Akt signaling pathway Mol Med Rep, 2018-07-30;18(3):3332-3340. 2018-07-30 [PMID: 30066927] (Western Blot, Rat)
• M Baek, M Kim, JS Lim, LD Morales, J Hernandez, S Mummidi, S Williams-B, IS Jang, AT Tsin, DJ Kim Epidermal-specific deletion of TC-PTP promotes UVB-induced epidermal cell survival through the regulation of Flk-1/JNK signaling Cell Death Dis, 2018-06-28;9(7):730. 2018-06-28 [PMID: 29955047] (Human)
• ML Piacentino, ME Bronner Intracellular attenuation of BMP signaling via CKIP-1/Smurf1 is essential during neural crest induction PLoS Biol., 2018-06-27;16(6):e2004425. 2018-06-27 [PMID: 29949573] (IHC-P, Chicken)
• I Cohen, D Zhao, C Bar, VJ Valdes, KL Dauber-Dec, MB Nguyen, M Nakayama, M Rendl, WA Bickmore, H Koseki, D Zheng, E Ezhkova PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification Cell Stem Cell, 2018-05-03;22(5):726-739.e7. 2018-05-03 [PMID: 29727681] (IHC, Mouse)
• R Barbieri, A Contestabi, MG Ciardo, N Forte, A Marte, P Baldelli, F Benfenati, F Onofri Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice Oncotarget, 2018-04-10;9(27):18760-18774. 2018-04-10 [PMID: 29721159] (IHC, Mouse)
• E Indersie, KB Hooks, C Capdeviell, M Fabre, N Dugot-Sena, A Desplat, S Lepreux, A Merched, CF Grosset, M Hagedorn Tracking cellular and molecular changes in a species-specific manner during experimental tumor progression in vivo Oncotarget, 2018-03-01;9(22):16149-16162. 2018-03-01 [PMID: 29662633] (IHC, Human)
• P Srikanth, VN Lagomarsin, CR Muratore, SC Ryu, A He, WM Taylor, C Zhou, M Arellano, TL Young-Pear Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids Transl Psychiatry, 2018-04-12;8(1):77. 2018-04-12 [PMID: 29643329] (ICC, Mouse)
• PLN da Costa, D Wynne, T Fifis, L Nguyen, M Perini, C Christophi The kallikrein-Kinin system modulates the progression of colorectal liver metastases in a mouse model BMC Cancer, 2018-04-04;18(1):382. 2018-04-04 [PMID: 29618333] (IHC, Mouse)
• N Antoniou, D Vlachakis, A Memou, E Leandrou, PE Valkimadi, K Melachroin, DB Re, S Przedborsk, WT Dauer, L Stefanis, HJ Rideout A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway Sci Rep, 2018-02-22;8(1):3455. 2018-02-22 [PMID: 29472595] (ICC, Mouse)
• JM Povedano, P Martinez, R Serrano, Á Tejera, G Gómez-Lópe, M Bobadilla, JM Flores, F Bosch, MA Blasco Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres Elife, 2018-01-30;7(0):. 2018-01-30 [PMID: 29378675] (IHC-P, Mouse)
• D Skuk, JP Tremblay The Process of Engraftment of Myogenic Cells in Skeletal Muscles of Primates: Understanding Clinical Observations and Setting Directions in Cell Transplantation Research Cell Transplant, 2017-11-01;26(11):1763-1779. 2017-11-01 [PMID: 29338383] (IHC, Primate)
• N Dreyer-And, AS Almeida, P Jensen, M Kamand, J Okarmus, T Rosenberg, SD Friis, A Martínez S, M Blaabjerg, BW Kristensen, T Skrydstrup, JB Gramsberge, HLA Vieira, M Meyer Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells PLoS ONE, 2018-01-16;13(1):e0191207. 2018-01-16 [PMID: 29338033] (ICC, Human)
• C Ambrogio, J Köhler, ZW Zhou, H Wang, R Paranal, J Li, M Capelletti, C Caffarra, S Li, Q Lv, S Gondi, JC Hunter, J Lu, R Chiarle, D Santamaría, KD Westover, PA Jänne KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS Cell, 2018-01-11;0(0):. 2018-01-11 [PMID: 29336889] (IHC-P, Mouse)
• CA Lyon, H Williams, R Bianco, SJ Simmonds, BA Brown, KS Wadey, FCT Smith, JL Johnson, SJ George Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression Sci Rep, 2017-12-11;7(1):17342. 2017-12-11 [PMID: 29229950] (ICC, IHC, Human, Mouse)
• MK Shim, HY Yoon, S Lee, MK Jo, J Park, JH Kim, SY Jeong, IC Kwon, K Kim Caspase-3/-7-Specific Metabolic Precursor for Bioorthogonal Tracking of Tumor Apoptosis Sci Rep, 2017-11-30;7(1):16635. 2017-11-30 [PMID: 29192289] (Western Blot, Human)
• M Dezest, M Le Bechec, L Chavatte, V Desauziers, B Chaput, JL Grolleau, P Descargues, C Nizard, S Schnebert, S Lacombe, AL Bulteau Oxidative damage and impairment of protein quality control systems in keratinocytes exposed to a volatile organic compounds cocktail Sci Rep, 2017-09-06;7(1):10707. 2017-09-06 [PMID: 28878258] (IHC, IHC-P, Human)
• C Tu, R Xu, M Koleti, J Zoldan Glycogen synthase kinase-3 inhibition sensitizes human induced pluripotent stem cells to thiol-containing antioxidants induced apoptosis Stem Cell Res, 2017-07-22;23(0):182-187. 2017-07-22 [PMID: 28772167] (Functional Assay, Human)
• DJ Flanagan, N Barker, C Nowell, H Clevers, M Ernst, TJ Phesse, E Vincan Loss of the Wnt receptor Frizzled7 in the gastric epithelium is deleterious and triggers rapid repopulation in vivo Dis Model Mech, 2017-06-09;0(0):. 2017-06-09 [PMID: 28600348] (IHC, Mouse)
• F Oozeer, LL Yates, C Dean, CJ Formstone A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin Sci Rep, 2017-05-12;7(1):1880. 2017-05-12 [PMID: 28500339] (IHC, Mouse)
• F Cartier, E Indersie, S Lesjean, J Charpentie, KB Hooks, A Ghousein, A Desplat, N Dugot-Sena, V Trézéguet, F Sagliocco, M Hagedorn, CF Grosset New tumor suppressor microRNAs target glypican-3 in human liver cancer Oncotarget, 2017-06-20;0(0):. 2017-06-20 [PMID: 28476031] (IHC, Chicken)
• Lynne A Murray, Rebecca Dunmore, Ana Camelo, Carla A Da Silva, Malin J Gustavsso, David M Habiel, Tillie L Hackett, Cory M Hogaboam, Matthew A Sleeman, Darryl A Knight Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium. Respiratory Research, 2017-05-03;0(0):1465-993X. 2017-05-03 [PMID: 28468623] (IHC, Mouse)
• AA Chassot, M Le Rolle, M Jourden, MM Taketo, NB Ghyselinck, MC Chaboissie Constitutive WNT/CTNNB1 activation triggers spermatogonial stem cell proliferation and germ cell depletion Dev. Biol., 2017-04-26;0(0):. 2017-04-26 [PMID: 28456466] (IHC-P, Mouse)
• JY Jang, SY Choi, I Park, DY Park, K Choe, P Kim, YK Kim, BJ Lee, M Hirashima, Y Kubota, JW Park, SY Cheng, A Nagy, YJ Park, K Alitalo, M Shong, GY Koh VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis EMBO Mol Med, 2017-06-01;0(0):. 2017-06-01 [PMID: 28438786] (IHC, Mouse)
• S Grasso, J Chapelle, V Salemme, S Aramu, I Russo, N Vitale, L Verdun di, K Dallaglio, I Castellano, A Amici, G Centonze, N Sharma, S Lunardi, S Cabodi, F Cavallo, A Lamolinara, L Stramucci, E Moiso, P Provero, A Albini, A Sapino, J Staaf, PP Di Fiore, G Bertalot, S Pece, D Tosoni, S Confalonie, M Iezzi, P Di Stefano, E Turco, P Defilippi The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries Nat Commun, 2017-03-16;8(0):14797. 2017-03-16 [PMID: 28300085] (IHC, Mouse)
• JC Klein, K Moses, G Zelinskyy, S Sody, J Buer, S Lang, I Helfrich, U Dittmer, CJ Kirschning, S Brandau Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth Nat Commun, 2017-03-16;8(0):14600. 2017-03-16 [PMID: 28300057] (IHC, Mouse)
• KR Hughes, LC Harnisch, C Alcon-Gine, S Mitra, CJ Wright, J Ketskemety, D van Sinder, AJ Watson, LJ Hall Bifidobacterium breve reduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD88-dependent manner Open Biol, 2017-01-01;7(1):. 2017-01-01 [PMID: 28123052] (IHC-P, Mouse)
• T Revenco, G Lapouge, V Moers, S Broh‚e, PA Sotiropoul Low Dose Radiation Causes Skin Cancer In Mice And Has A Differential Effect on Distinct Epidermal Stem Cells Stem Cells, 2017-02-01;0(0):. 2017-02-01 [PMID: 28100039] (IHC-P, Mouse)
• Y He, H Huang, C Farischon, D Li, Z Du, K Zhang, X Zheng, S Goodin Combined effects of atorvastatin and aspirin on growth and apoptosis in human prostate cancer cells Oncol. Rep, 2017-01-04;37(2):953-960. 2017-01-04 [PMID: 28075470] (ICC, Human)
• Autophagy deficient keratinocytes display increased DNA damage, senescence and aberrant lipid composition after oxidative stress in vitro and in vivo Redox Biol, 2016-12-18;11(0):219-230. 2016-12-18 [PMID: 28012437] (Western Blot, Mouse)
• cMyc Regulates the Size of the Premigratory Neural Crest Stem Cell Pool Cell Rep, 2016-12-06;17(10):2648-2659. 2016-12-06 [PMID: 27926868] (IHC, Mouse)
• Simon X Liang Proliferation, differentiation and migration of SCA1(-)/CD31(-) cardiac side population cells in vitro and in vivo Int. J. Cardiol., 2016-11-09;0(0):. 2016-11-09 [PMID: 27847151] (IHC, Mouse)
• Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations PLoS ONE, 2016-11-10;11(11):e0166053. 2016-11-10 [PMID: 27832104] (IHC, Human)
• Karina S Cramer Axonal Cleaved Caspase-3 Regulates Axon Targeting and Morphogenesis in the Developing Auditory Brainstem Front Neural Circuits, 2016-10-24;10(0):84. 2016-10-24 [PMID: 27822180] (IHC, Chicken)
• CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex Stem Cell Reports, 2016-07-12;7(1):69-79. 2016-07-12 [PMID: 27411104] (IHC, Mouse)
• M-C De Cian Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary Oncogene, 2016-06-06;0(0):. 2016-06-06 [PMID: 27270435] (IHC-P, Mouse)
• Defining the cellular lineage hierarchy in the interfollicular epidermis of adult skin Nat. Cell Biol., 2016-05-16;18(6):619-31. 2016-05-16 [PMID: 27183471] (IHC, Mouse)
• Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice J Neurosci, 2016-04-27;36(17):4758-70. 2016-04-27 [PMID: 27122034] (IHC, Mouse)
• SR Berkowicz, TJ Featherby, Z Qu, A Giousoh, NA Borg, JI Heng, JC Whisstock, PI Bird Brinp1 (-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density Mol Autism, 2016-03-31;7(0):22. 2016-03-31 [PMID: 27042284] (IHC-Fr, Mouse)
• Jacob F, Yonis A, Cuello F, Luther P, Schulze T, Eder A, Streichert T, Mannhardt I, Hirt M, Schaaf S, Stenzig J, Force T, Eschenhagen T, Hansen A Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue. PLoS ONE, 2016-02-03;11(2):e0145937. 2016-02-03 [PMID: 26840448] (IHC-P, Rat)
• Amelkina O, Zschockelt L, Painer J, Serra R, Villaespesa F, Braun B, Jewgenow K Apoptosis-Related Factors in the Luteal Phase of the Domestic Cat and Their Involvement in the Persistence of Corpora Lutea in Lynx. PLoS ONE, 2015-11-24;10(11):e0143414. 2015-11-24 [PMID: 26599641] (IHC-P, Feline)
• JD Aridas, CA McDonald, MC Paton, T Yawno, AE Sutherland, I Nitsos, Y Pham, M Ditchfield, MC Fahey, F Wong, A Malhotra, M Castillo-M, K Bhakoo, EM Wallace, G Jenkin, SL Miller Cord blood mononuclear cells prevent neuronal apoptosis in response to perinatal asphyxia in the newborn lamb J. Physiol. (Lond.), 2015-12-14;594(5):1421-35. 2015-12-14 [PMID: 26527561] (IHC-P, Mouse)
• Wong J, Chen L, Huang Y, Sehba F, Friedel R, Zou H Attenuation of Cerebral Ischemic Injury in Smad1 Deficient Mice. PLoS ONE, 2015-08-28;10(8):e0136967. 2015-08-28 [PMID: 26317208] (IHC-Fr, Mouse)
• Quereda V, Porlan E, Canamero M, Dubus P, Malumbres M An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress. Cell Death Differ, 2015-08-21;23(3):430-41. 2015-08-21 [PMID: 26292757] (IHC-P, Mouse)
• Douglas T, Champagne C, Morizot A, Lapointe J, Saleh M The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice. J Immunol, 2015-07-27;195(5):2365-73. 2015-07-27 [PMID: 26216893] (IHC-P, Mouse)
• Levet S, Ouarne M, Ciais D, Coutton C, Subileau M, Mallet C, Ricard N, Bidart M, Debillon T, Faravelli F, Rooryck C, Feige J, Tillet E, Bailly S BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus. Proc Natl Acad Sci U S A, 2015-06-08;112(25):E3207-15. 2015-06-08 [PMID: 26056270] (IHC, Mouse)
• Sun H, Lou Y, Porturas T, Morrissey S, Luo G, Qi J, Ruan Q, Shi S, Chen Y Exacerbated experimental colitis in TNFAIP8-deficient mice. J Immunol, 2015-05-06;194(12):5736-42. 2015-05-06 [PMID: 25948814] (IHC-P, Mouse)
• Brindle N, Joyce J, Rostker F, Lawlor E, Swigart-Brown L, Evan G, Hanahan D, Shchors K Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer. PLoS ONE, 2015-04-30;10(4):e0120348. 2015-04-30 [PMID: 25927437] (IHC, Mouse)
• Sharma S, Chintala N, Vadrevu S, Patel J, Karbowniczek M, Markiewski M Pulmonary alveolar macrophages contribute to the premetastatic niche by suppressing antitumor T cell responses in the lungs. J Immunol, 2015-04-24;194(11):5529-38. 2015-04-24 [PMID: 25911761] (Flow Cytometry, Mouse)
• Declercq , Annelies, Chiers , Koen, Van den Broeck , Wim, Dewulf , Jeroen, Eeckhaut , Venessa, Cornelissen , Maria, Bossier , Peter, Haesebrouck , Freddy, Decostere , Annemie Interactions of highly and low virulent Flavobacterium columnare isolates with gill tissue in carp and rainbow trout. Vet Res, 2015-03-06;46(0):25. 2015-03-06 [PMID: 25889257] (IHC-P, Fish - Cyprinus carpio (Carp), Fish - Oncorhynchus mykiss (Rainbow Trout))
• Sesen J, Dahan P, Scotland S, Saland E, Dang V, Lemarie A, Tyler B, Brem H, Toulas C, Cohen-Jonathan Moyal E, Sarry J, Skuli N Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response. PLoS ONE, 2015-04-13;10(4):e0123721. 2015-04-13 [PMID: 25867026] (IHC, Mouse)
• Scott C, Cha K, Rao R, Liddle C, George J, Gunton J Hepatocyte-specific deletion of ARNT (aryl hydrocarbon Receptor Nuclear Translocator) results in altered fibrotic gene expression in the thioacetamide model of liver injury. PLoS ONE, 2015-03-26;10(3):e0121650. 2015-03-26 [PMID: 25812120] (IHC-P, Mouse)
• Matsuda T, Murao N, Katano Y, Juliandi B, Kohyama J, Akira S, Kawai T, Nakashima K TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus. Nat Commun, 2015-03-09;6(0):6514. 2015-03-09 [PMID: 25751136] (ICC, Mouse)
• Luyet C, Schulze K, Sayar B, Howald D, Muller E, Galichet A Preclinical studies identify non-apoptotic low-level caspase-3 as therapeutic target in pemphigus vulgaris. PLoS ONE, 2015-03-06;10(3):e0119809. 2015-03-06 [PMID: 25748204] (ICC, Mouse)
• Sawhney S, Hood K, Shaw A, Braithwaite A, Stubbs R, Hung N, Royds J, Slatter T Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a 133p53alpha mimic. PLoS ONE, 2015-02-02;10(2):e0116270. 2015-02-02 [PMID: 25643152] (IHC-P, Mouse)
• Petersson , Monika, Reuter , Karen, Brylka , Heike, Kraus , Andreas, Schettina , Peter, Niemann , Catherin Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours. Nat Commun, 2015-01-22;6(0):5874. 2015-01-22 [PMID: 25608467] (IHC, Mouse)
• Moyon S, Dubessy A, Aigrot M, Trotter M, Huang J, Dauphinot L, Potier M, Kerninon C, Melik Parsadaniantz S, Franklin R, Lubetzki C Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration. J Neurosci, 2015-01-07;35(1):4-20. 2015-01-07 [PMID: 25568099] (IHC-Fr, Mouse)
• Mracsko E, Liesz A, Stojanovic A, Lou W, Osswald M, Zhou W, Karcher S, Winkler F, Martin-Villalba A, Cerwenka A, Veltkamp R Antigen dependently activated cluster of differentiation 8-positive T cells cause perforin-mediated neurotoxicity in experimental stroke. J Neurosci, 2014-12-10;34(50):16784-95. 2014-12-10 [PMID: 25505331] (ICC, Mouse)
• Yen T, Alison M, Goodlad R, Otto W, Jeffery R, Cook H, Wright N, Poulsom R Epidermal growth factor attenuates tubular necrosis following mercuric chloride damage by regeneration of indigenous, not bone marrow-derived cells. J Cell Mol Med, 2014-11-11;19(2):463-73. 2014-11-11 [PMID: 25389045] (IHC-P, Mouse)
• Fowler , Anna-Kat, Thompson , Jeremy, Chen , Lixia, Dagda , Marisela, Dertien , Janet, Dossou , Katina S, Moaddel , Ruin, Bergeson , Susan E, Kruman , Inna I Differential sensitivity of prefrontal cortex and hippocampus to alcohol-induced toxicity. PLoS ONE, 2014-09-04;9(9):e106945. 2014-09-04 [PMID: 25188266] (IHC, Mouse)
• Lindgren G, Ekblad L, Vallon-Christersson J, Kjellen E, Gebre-Medhin M, Wennerberg J Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma. BMC Cancer, 2014-09-02;14(0):648. 2014-09-02 [PMID: 25182342] (IHC, Mouse)
• Willner D, Cohen-Yeshurun A, Avidan A, Ozersky V, Shohami E, Leker R Short term morphine exposure in vitro alters proliferation and differentiation of neural progenitor cells and promotes apoptosis via mu receptors. PLoS ONE, 2014-07-29;9(7):e103043. 2014-07-29 [PMID: 25072277] (IHC, Mouse)
• Park D, Lee J, Park I, Choi D, Lee S, Song S, Hwang Y, Hong K, Nakaoka Y, Makinen T, Kim P, Alitalo K, Hong Y, Koh G Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity. J Clin Invest, 2014-07-25;124(9):3960-74. 2014-07-25 [PMID: 25061877] (IHC, Mouse)
• Deng M, Luo X, Pan L, Yang H, Xie X, Liang G, Huang L, Hu F, Kiernan A, Gan L LMO4 functions as a negative regulator of sensory organ formation in the mammalian cochlea. J Neurosci, 2014-07-23;34(30):10072-7. 2014-07-23 [PMID: 25057208] (IHC, Mouse)
• Grahammer F, Haenisch N, Steinhardt F, Sander L, Roerden M, Arnold F, Cordts T, Wanner N, Reichardt W, Kerjaschki D, Ruegg M, Hall M, Moulin P, Busch H, Boerries M, Walz G, Artunc F, Huber T mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proc Natl Acad Sci U S A, 2014-06-23;111(27):E2817-26. 2014-06-23 [PMID: 24958889] (IHC, Mouse)
• Wiener Z, Band A, Kallio P, Hogstrom J, Hyvonen V, Kaijalainen S, Ritvos O, Haglund C, Kruuna O, Robine S, Louvard D, Ben-Neriah Y, Alitalo K Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-beta. Proc Natl Acad Sci U S A, 2014-05-13;111(21):E2229-36. 2014-05-13 [PMID: 24825889] (Flow Cytometry, IHC, Mouse)
• Krabbe C, Bak S, Jensen P, von Linstow C, Martinez Serrano A, Hansen C, Meyer M Influence of oxygen tension on dopaminergic differentiation of human fetal stem cells of midbrain and forebrain origin. PLoS ONE, 2014-05-02;9(5):e96465. 2014-05-02 [PMID: 24788190] (ICC, Mouse)
• Kumar L, Chou J, Yee C, Borzutzky A, Vollmann E, von Andrian U, Park S, Hollander G, Manis J, Poliani P, Geha R Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. J Exp Med, 2014-04-21;211(5):929-42. 2014-04-21 [PMID: 24752297] (IHC, Mouse)
• Losa D, Kohler T, Bellec J, Dudez T, Crespin S, Bacchetta M, Boulanger P, Hong S, Morel S, Nguyen T, van Delden C, Chanson M Pseudomonas aeruginosa-induced apoptosis in airway epithelial cells is mediated by gap junctional communication in a JNK-dependent manner. J Immunol, 2014-04-14;192(10):4804-12. 2014-04-14 [PMID: 24733844] (Western Blot, Human)
• Martinez P, Ferrara-Romeo I, Flores J, Blasco M Essential role for the TRF2 telomere protein in adult skin homeostasis. Aging Cell, 2014-04-14;13(4):656-68. 2014-04-14 [PMID: 24725274] (IHC-P, Mouse)
• Edlund R, Ohyama T, Kantarci H, Riley B, Groves A Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers. Dev Biol, 2014-03-18;390(1):1-13. 2014-03-18 [PMID: 24650709] (IHC, Mouse)
• Chu H, Liao Y, Novak J, Hu Z, Merkin J, Shymkiv Y, Braeckman B, Dorovkov M, Nguyen A, Clifford P, Nagele R, Harrison D, Ellis R, Ryazanov A Germline quality control: eEF2K stands guard to eliminate defective oocytes. Dev Cell, 2014-02-27;28(5):561-72. 2014-02-27 [PMID: 24582807] (IHC, Mouse)
• Saraga M, Vukojevic K, Krzelj V, Puretic Z, Bocina I, Durdov M, Weber S, Dworniczak B, Ljubanovic D, Saraga-Babic M Mechanism of cystogenesis in nephrotic kidneys: a histopathological study. BMC Nephrol, 2014-01-08;15(0):3. 2014-01-08 [PMID: 24397250] (IHC, Human)
• Brookes , Steven J, Barron , Martin J, Boot-Handford , Ray, Kirkham , Jennifer, Dixon , Michael Endoplasmic reticulum stress in amelogenesis imperfecta and phenotypic rescue using 4-phenylbutyrate. Hum Mol Genet, 2013-12-20;23(9):2468-80. 2013-12-20 [PMID: 24362885] (IHC, Mouse)
• Fan J, Ponferrada V, Sato T, Vemaraju S, Fruttiger M, Gerhardt H, Ferrara N, Lang R Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling. Development, 2013-12-18;141(2):448-59. 2013-12-18 [PMID: 24353059] (IHC, Mouse)
• Xu J, Xiao M, Jakovcevski I, Sivukhina E, Hargus G, Cui Y, Irintchev A, Schachner M, Bernreuther C The extracellular matrix glycoprotein tenascin-R regulates neurogenesis during development and in the adult dentate gyrus of mice. J Cell Sci, 2013-12-11;127(0):641-52. 2013-12-11 [PMID: 24338367] (IHC, Mouse)
• Tzeng , Tsai-Ten, Tsay , Huey-Jen, Chang , Luping, Hsu , Chia-Lin, Lai , Tzu-Hsua, Huang , Fong-Lee, Shiao , Young-Ji Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid. J Biomed Sci, 2013-12-06;20(0):90. 2013-12-06 [PMID: 24313976] (IHC-Fr, Mouse)
• Kerosuo L, Bronner M Biphasic influence of Miz1 on neural crest development by regulating cell survival and apical adhesion complex formation in the developing neural tube. Mol Biol Cell, 2013-12-04;25(3):347-55. 2013-12-04 [PMID: 24307680] (IHC, Chicken)
• Wahlin , Karl J, Enke , Raymond, Fuller , John A, Kalesnykas , Giedrius, Zack , Donald J, Merbs , Shannath Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death. PLoS ONE, 2013-11-11;8(11):e79140. 2013-11-11 [PMID: 24244436] (IHC-Fr, Chicken, Mouse)
• Perez de Castro I, Aguirre-Portoles C, Fernandez-Miranda G, Canamero M, Cowley D, Van Dyke T, Malumbres M Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals. Cancer Res, 2013-11-15;73(22):6804-15. 2013-11-15 [PMID: 24242071] (IHC, Mouse)
• Ling , Xiang, Bao , Feng, Qian , Hao, Liu , Danxia The temporal and spatial profiles of cell loss following experimental spinal cord injury: effect of antioxidant therapy on cell death and functional recovery. BMC Neurosci, 2013-11-18;14(0):146. 2013-11-18 [PMID: 24238557] (IHC, Rat)
• Olive V, Sabio E, Bennett M, De Jong C, Biton A, McGann J, Greaney S, Sodir N, Zhou A, Balakrishnan A, Foth M, Luftig M, Goga A, Speed T, Xuan Z, Evan G, Wan Y, Minella A, He L A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. Elife, 2013-10-15;2(0):e00822. 2013-10-15 [PMID: 24137534] (IHC, Mouse)
• Chan S, Rickert C, Vermi W, Sheehan K, Arthur C, Allen J, White J, Archambault J, Lonardi S, McDevitt T, Bhattacharya D, Lorenzi M, Allred D, Schreiber R Dysregulated STAT1-SOCS1 control of JAK2 promotes mammary luminal progenitor cell survival and drives ERalpha(+) tumorigenesis. Cell Death Differ, 2013-09-13;21(2):234-46. 2013-09-13 [PMID: 24037089] (IHC-P, Mouse)
• Zamli Z, Adams M, Tarlton J, Sharif M Increased chondrocyte apoptosis is associated with progression of osteoarthritis in spontaneous Guinea pig models of the disease. Int J Mol Sci, 2013-08-29;14(9):17729-43. 2013-08-29 [PMID: 23994836] (IHC, Guinea Pig)
• Hwang J, Hsu C, Yu W, Liu T, Yang W Diet-induced obesity exacerbates auditory degeneration via hypoxia, inflammation, and apoptosis signaling pathways in CD/1 mice. PLoS ONE, 2013-04-26;8(4):e60730. 2013-04-26 [PMID: 23637762] (IHC, Mouse)
• Stott , Simon R, Metzakopian , Emmanoui, Lin , Wei, Kaestner , Klaus H, Hen , Rene, Ang , Siew-Lan Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages. J Neurosci, 2013-05-01;33(18):8022-34. 2013-05-01 [PMID: 23637192] (IHC, Mouse)
• Shakibaei M, Mobasheri A, Lueders C, Busch F, Shayan P, Goel A Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-kappaB and Src protein kinase signaling pathways. PLoS ONE, 2013-02-22;8(2):e57218. 2013-02-22 [PMID: 23451189] (Western Blot, Human)
• Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis. Cell Death Differ., 2012-05-04;19(11):1761-8. 2012-05-04 [PMID: 22555459] (IHC-P, Mouse)
• McIntyre A, Patiar S, Wigfield S Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy. Clin. Cancer Res., 2012-04-12;18(11):3100-11. 2012-04-12 [PMID: 22498007] (IHC, Human)
• Chen T, Heller E, Beronja S, Oshimori N, Stokes N, Fuchs E An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration. Nature, 2012-04-04;485(7396):104-8. 2012-04-04 [PMID: 22495305] (IHC-Fr, Mouse)
• Fuxe J, Tabruyn S, Colton K, Zaid H, Adams A, Baluk P, Lashnits E, Morisada T, Le T, O'Brien S, Epstein DM, Koh GY, McDonald DM Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation. Am. J. Pathol., 2011-05-06;178(6):2897-909. 2011-05-06 [PMID: 21550017] (IHC, Mouse)
• Hernandez-Miranda LR, Cariboni A, Faux C, Ruhrberg C, Cho JH, Cloutier JF, Eickholt BJ, Parnavelas JG, Andrews WD Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain. J. Neurosci., 2011-04-20;31(16):6174-87. 2011-04-20 [PMID: 21508241] (IHC-Fr, Mouse)
• Perez CJ, Jaubert J, Guenet JL, Barnhart KF, Ross-Inta CM, Quintanilla VC, Aubin I, Brandon JL, Otto NW, DiGiovanni J, Gimenez-Conti I, Giulivi C, Kusewitt DF, Conti CJ, Benavides F Two hypomorphic alleles of mouse Ass1 as a new animal model of citrullinemia type I and other hyperammonemic syndromes. Am. J. Pathol., 2010-08-19;177(4):1958-68. 2010-08-19 [PMID: 20724589] (IHC-P, Mouse)
• Sotiropoulou PA, Candi A, Mascre G, De Clercq S, Youssef KK, Lapouge G, Dahl E, Semeraro C, Denecker G, Marine JC, Blanpain C Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death. Nat. Cell Biol., 2010-05-16;12(6):572-82. 2010-05-16 [PMID: 20473297] (Flow Cytometry, ICC, Mouse)
• Li H, Kloosterman W, Fekete DM MicroRNA-183 family members regulate sensorineural fates in the inner ear. J. Neurosci., 2010-03-03;30(9):3254-63. 2010-03-03 [PMID: 20203184] (IHC, Zebrafish)
• Hashizume H, Falcon BL, Kuroda T, Baluk P, Coxon A, Yu D, Bready JV, Oliner JD, McDonald DM Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth. Cancer Res., 2010-03-02;70(6):2213-23. 2010-03-02 [PMID: 20197469] (IHC, Human)
• Niessen K, Zhang G, Ridgway JB, Chen H, Yan M ALK1 signaling regulates early postnatal lymphatic vessel development. Blood, 2009-11-10;115(8):1654-61. 2009-11-10 [PMID: 19903896] (IHC, Mouse)
• Yawno T, Hirst JJ, Castillo-Melendez M, Walker DW Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain. Neuroscience, 2009-07-08;163(3):838-47. 2009-07-08 [PMID: 19591903] (IHC-P, Ovine)
• Fischer AJ, Scott MA, Ritchey ER, Sherwood P Mitogen-activated protein kinase-signaling regulates the ability of Muller glia to proliferate and protect retinal neurons against excitotoxicity. Glia, 2009-11-01;57(14):1538-52. 2009-11-01 [PMID: 19306360] (IHC-Fr, Chicken)
• Borchers MT, Wesselkamper SC, Curull V, Ramirez-Sarmiento A, Sanchez-Font A, Garcia-Aymerich J, Coronell C, Lloreta J, Agusti AG, Gea J, Howington JA, Reed MF, Starnes SL, Harris NL, Vitucci M, Eppert BL, Motz GT, Fogel K, McGraw DW, Tichelaar JW, Orozco-Levi M Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease. J. Clin. Invest., 2009-02-09;119(3):636-49. 2009-02-09 [PMID: 19197141] (IHC-P, Mouse)
• Stedman A, Lecaudey V, Havis E, Anselme I, Wassef M, Gilardi-Hebenstreit P, Schneider-Maunoury S A functional interaction between Irx and Meis patterns the anterior hindbrain and activates krox20 expression in rhombomere 3. Dev. Biol., 2008-12-25;327(2):566-77. 2008-12-25 [PMID: 19152797] (IHC, Zebrafish)
• Sozo F, O'Day L, Maritz G, Kenna K, Stacy V, Brew N, Walker D, Bocking A, Brien J, Harding R Repeated ethanol exposure during late gestation alters the maturation and innate immune status of the ovine fetal lung. Am. J. Physiol. Lung Cell Mol. Physiol., 2008-12-26;296(3):L510-8. 2008-12-26 [PMID: 19112099] (IHC-P, Ovine)
• Michaelis M, Bliss J, Arnold SC, Hinsch N, Rothweiler F, Deubzer HE, Witt O, Langer K, Doerr HW, Wels WS, Cinatl J Cisplatin-resistant neuroblastoma cells express enhanced levels of epidermal growth factor receptor (EGFR) and are sensitive to treatment with EGFR-specific toxins. Clin. Cancer Res., 2008-10-15;14(20):6531-7. 2008-10-15 [PMID: 18927293] (ICC, Human)
• Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Yla-Herttuala S, Wedge SR, Jurgensmeier JM, Alitalo K The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis. Cancer Res., 2008-06-15;68(12):4754-62. 2008-06-15 [PMID: 18559522] (ICC, Human)
• Boncoeur E, Roque T, Bonvin E, Saint-Criq V, Bonora M, Clement A, Tabary O, Henrion-Caude A, Jacquot J Cystic fibrosis transmembrane conductance regulator controls lung proteasomal degradation and nuclear factor-kappaB activity in conditions of oxidative stress. Am. J. Pathol., 2008-03-27;172(5):1184-94. 2008-03-27 [PMID: 18372427] (IHC-P, Mouse)
• Siegl-Cachedenier I, Flores I, Klatt P, Blasco MA Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres. J. Cell Biol., 2007-10-22;179(2):277-90. 2007-10-22 [PMID: 17954610] (IHC-P, Mouse)
• Benosman S, Gross I, Clarke N, Jochemsen AG, Okamoto K, Loeffler JP, Gaiddon C Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis. Cell Death Differ., 2007-09-07;14(12):2047-57. 2007-09-07 [PMID: 17823617] (ICC, Mouse)
• Bond JA, Gescher AJ, Verschoyle RD, Lemoine NR, Errington R, Wiltshire M, Smith PJ, Wynford-Thomas D Cytotoxic action of phorbol esters on human pancreatic cancer cells. Int. J. Cancer, 2007-10-01;121(7):1445-54. 2007-10-01 [PMID: 17582609] (ICC, Human)
• Wu F, Chiocca S, Beck WT, Mo YY Gam1-associated alterations of drug responsiveness through activation of apoptosis. Mol. Cancer Ther., 2007-06-01;6(6):1823-30. 2007-06-01 [PMID: 17575111] (ICC, Human)
• Yawno T, Yan EB, Walker DW, Hirst JJ Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep. Neuroscience, 2007-04-20;146(4):1726-33. 2007-04-20 [PMID: 17449186] (IHC-P, Ovine)
• Blouw B, Haase VH, Song H, Bergers G, Johnson RS Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene. Oncogene, 2007-02-05;26(31):4531-40. 2007-02-05 [PMID: 17297464] (IHC, Mouse)
• Xue M, Campbell D, Jackson CJ Protein C is an autocrine growth factor for human skin keratinocytes. J. Biol. Chem., 2007-02-09;282(18):13610-6. 2007-02-09 [PMID: 17293597] (Western Blot, Human)
• do Vale A, Costa-Ramos C, Silva DS, Macedo PM, Fernandes R, Sampaio P, Dos Santos NM, Silva MT Cytochemical and ultrastructural study of anoikis and secondary necrosis in enterocytes detached in vivo. Apoptosis, 2007-06-01;12(6):1069-83. 2007-06-01 [PMID: 17245641] (IHC-P, Fish)
• Fessing MY, Sharova TY, Sharov AA, Atoyan R, Botchkarev VA Involvement of the Edar signaling in the control of hair follicle involution (catagen). Am. J. Pathol., 2006-12-01;169(6):2075-84. 2006-12-01 [PMID: 17148670] (IHC-Fr, Mouse)
• Blanpain C, Lowry WE, Pasolli HA, Fuchs E Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev., 2006-11-01;20(21):3022-35. 2006-11-01 [PMID: 17079689] (IHC, Mouse)
• Harris LK, Keogh RJ, Wareing M, Baker PN, Cartwright JE, Aplin JD, Whitley GS Invasive trophoblasts stimulate vascular smooth muscle cell apoptosis by a fas ligand-dependent mechanism. Am. J. Pathol., 2006-11-01;169(5):1863-74. 2006-11-01 [PMID: 17071607] (IHC-Fr, Human)
• Rodriguez-Guzman M, Montero JA, Santesteban E, Ganan Y, Macias D, Hurle JM Tendon-muscle crosstalk controls muscle bellies morphogenesis, which is mediated by cell death and retinoic acid signaling. Dev. Biol., 2006-09-26;302(1):267-80. 2006-09-26 [PMID: 17070795] (IHC, Chicken)
• Hendriksen PJ, Dits NF, Kokame K, Veldhoven A, van Weerden WM, Bangma CH, Trapman J, Jenster G Evolution of the androgen receptor pathway during progression of prostate cancer. Cancer Res., 2006-05-15;66(10):5012-20. 2006-05-15 [PMID: 16707422] (ICC, Human)
• Kossmehl P, Kurth E, Faramarzi S, Habighorst B, Shakibaei M, Wehland M, Kreutz R, Infanger M, J Danser AH, Grosse J, Paul M, Grimm D Mechanisms of apoptosis after ischemia and reperfusion: role of the renin-angiotensin system. Apoptosis, 2006-03-01;11(3):347-58. 2006-03-01 [PMID: 16538381] (Western Blot, Porcine)
• Jacomy H, Fragoso G, Almazan G, Mushynski WE, Talbot PJ Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice. Virology, 2006-03-09;349(2):335-46. 2006-03-09 [PMID: 16527322] (ICC, Mouse)
• Ohyama T, Mohamed OA, Taketo MM, Dufort D, Groves AK Wnt signals mediate a fate decision between otic placode and epidermis. Development, 2006-02-01;133(5):865-75. 2006-02-01 [PMID: 16452098] (IHC, Mouse)
• Grzmil M, Kaulfuss S, Thelen P, Hemmerlein B, Schweyer S, Obenauer S, Kang TW, Burfeind P Expression and functional analysis of Bax inhibitor-1 in human breast cancer cells. J. Pathol., 2006-02-01;208(3):340-9. 2006-02-01 [PMID: 16353131] (ICC, Human)
• De Bock M, Decostere A, Hellemans A, Haesebrouck F, Ducatelle R Helicobacter felis and Helicobacter bizzozeronii induce gastric parietal cell loss in Mongolian gerbils. Microbes Infect., 2005-10-11;8(2):503-10. 2005-10-11 [PMID: 16311055] (IHC, Mouse)
• Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noel A, Cataldo DD Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J. Immunol., 2005-08-15;175(4):2589-97. 2005-08-15 [PMID: 16081833] (IHC-P, Mouse)
• Geenen K, Favoreel HW, Nauwynck HJ Higher resistance of porcine trigeminal ganglion neurons towards pseudorabies virus-induced cell death compared with other porcine cell types in vitro. J. Gen. Virol., 2005-05-01;86(0):1251-60. 2005-05-01 [PMID: 15831935] (ICC, Porcine)
• Schlott T, Taubert H, Fayyazi A, Schweyer S, Bartel F, Korabiowska M, Brinck U Analysis of central regulatory pathways in p53-deficient primary cultures of malignant fibrous histiocytoma exposed to ifosfamide. Anticancer Res., 2004-11-01;24(6):3819-29. 2004-11-01 [PMID: 15736417] (ICC, Human)
• Glamoclija V, Vilovic K, Saraga-Babic M, Baranovic A, Sapunar D Apoptosis and active caspase-3 expression in human granulosa cells. Fertil. Steril., 2005-02-01;83(2):426-31. 2005-02-01 [PMID: 15705385] (ICC, IHC-P, Human)
• Kuo LT, Simpson A, Schanzer A, Tse J, An SF, Scaravilli F, Groves MJ Effects of systemically administered NT-3 on sensory neuron loss and nestin expression following axotomy. J. Comp. Neurol., 2005-02-21;482(4):320-32. 2005-02-21 [PMID: 15669078] (ICC, Rat)
• Salomonsson S, Sonesson SE, Ottosson L, Muhallab S, Olsson T, Sunnerhagen M, Kuchroo VK, Thoren P, Herlenius E, Wahren-Herlenius M Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block. J. Exp. Med., 2005-01-03;201(1):11-7. 2005-01-03 [PMID: 15630133] (ICC, Rat)
• Geenen K, Favoreel HW, Olsen L, Enquist LW, Nauwynck HJ The pseudorabies virus US3 protein kinase possesses anti-apoptotic activity that protects cells from apoptosis during infection and after treatment with sorbitol or staurosporine. Virology, 2005-01-05;331(1):144-50. 2005-01-05 [PMID: 15582661] (ICC, Porcine)
• Zitterkopf NL, McNeal DW, Eyster KM, Bradley DS, Cafruny WA Lactate dehydrogenase-elevating virus induces apoptosis in cultured macrophages and in spinal cords of C58 mice coincident with onset of murine amyotrophic lateral sclerosis. Virus Res., 2004-11-01;106(1):35-42. 2004-11-01 [PMID: 15522445] (ICC, IHC-Fr, Mouse)
• Niquet J, Allen SG, Baldwin RA, Wasterlain CG Evidence of caspase-3 activation in hyposmotic stress-induced necrosis. Neurosci. Lett., 2004-02-19;356(3):225-7. 2004-02-19 [PMID: 15036635] (ICC, Rat)
• Grzmil M, Hemmerlein B, Thelen P, Schweyer S, Burfeind P Blockade of the type I IGF receptor expression in human prostate cancer cells inhibits proliferation and invasion, up-regulates IGF binding protein-3, and suppresses MMP-2 expression. J. Pathol., 2004-01-01;202(1):50-9. 2004-01-01 [PMID: 14694521] (ICC, Human, Mouse)
• Wang P, Valentijn AJ, Gilmore AP, Streuli CH Early events in the anoikis program occur in the absence of caspase activation. J. Biol. Chem., 2003-03-05;278(22):19917-25. 2003-03-05 [PMID: 12621032] (ICC, Mouse)

Reviews for Caspase-3 Antibody (AF835) (7)

Average Rating: 4.9

(Based on 7 reviews)

We have 7 reviews tested in 2 species: Mouse, Other.

reviewed by: Anonymous - WB Mouse 01/09/2015

Summary

• Application: Western Blot
• Sample Tested: See PMID 23374352
• Species: Mouse

reviewed by: Anonymous - IHC-P Mouse 01/09/2015

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: See PMID 20522641
• Species: Mouse

reviewed by: Anonymous - IHC-P Mouse 01/09/2015

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: See PMID 22897852
• Species: Mouse

reviewed by: Anonymous - IHC-P Other 01/09/2015

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: See PMID 22438018
• Species: Other

reviewed by: Anonymous - IF Mouse 01/09/2015

Summary

• Application: Immunofluorescence
• Sample Tested: See PMID 23532769
• Species: Mouse

reviewed by: Anonymous - IF Mouse 01/09/2015

Summary

• Application: Immunofluorescence
• Sample Tested: See PMID 19226508
• Species: Mouse

reviewed by: Anonymous - IHC-P Mouse 01/09/2015

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: See PMID 23742999
• Species: Mouse

Bioinformatics

• Gene Symbol: CASP3
• Uniprot:
  • P42574()