Caspase-3 Antibody [Unconjugated] - Active

Caspase‑3 was detected in immersion fixed anti-FAS treated Jurkat human acute T cell leukemia cell line using 0.3 µg/mL Human/Mouse Active Caspase‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) for 3 hours at room temperature. Cells were stained (red) and counterstained (green). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Caspase‑3 was detected in immersion fixed paraffin-embedded sections of human colon cancer tissue using Rabbit Anti-Human/Mouse Active Caspase‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) at 1 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Rabbit IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC003). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Caspase‑3 was detected in immersion fixed Jurkat human acute T cell leukemia cell line stimulated with staurosporin using Human/Mouse Active Caspase‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Rabbit IgG Secondary Antibody (yellow; Catalog # NL004) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

• Reactivity: Hu, Mu
• Applications: IHC, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: LYOPH

Caspase-3 Antibody [Unconjugated] - Active Summary

• Immunogen: KLH-coupled human Caspase-3 synthetic peptide
  CRGTELDCGIETD
  Accession # P42574
• Specificity: Distinguishes apoptotic cells from non-apoptotic cells in immunohistochemistry. Detects the p17 subunit of Caspase-3, but does not detect the precursor form in Western blot. We recommend R&D Systems Affinity Purified Anti-Caspase-3 (Catalog # AF-605-NA) or Monoclonal Anti-Cleaved-Caspase-3 (Catalog # MAB835) for Western blot applications.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CASP3

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1-15 ug/mL
  • Immunocytochemistry 5-15 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Caspase-3 Antibody [Unconjugated] - Active

• Apopain
• apoptosis-related cysteine protease
• CASP3
• CASP-3
• caspase 3, apoptosis-related cysteine peptidase
• Caspase3
• Caspase-3
• CPP32
• CPP-32
• CPP32B
• CPP32SREBP cleavage activity 1
• Cysteine protease CPP32
• EC 3.4.22
• EC 3.4.22.56
• LICE-1
• PARP cleavage protease
• procaspase3
• Protein Yama
• SCA-1
• YAMA

Background

Caspase-3 (Cysteine-aspartic acid protease 3/Casp3; also Yama, apopain and CPP32) is a 29 kDa heterodimer that belongs to the peptidase C14A family of enzymes. It is widely expressed, and considered to be the major executioner caspase in the apoptotic cascade. Human procaspase-3 is a 32 kDa, 277 amino acid (aa) protein and is normally an inactive homodimer. Following cell stress/activation, procaspase-3 undergoes proteolysis to generate an N-terminal 148 aa p17/17 kDa subunit (aa 29-175), plus a 102 aa C-terminal p12/12 kDa subunit. These subunits noncovalently heterodimerize, and associate with another p17/p12 heterodimer to form an active enzyme. There is one potential variant that shows an alternative start site nine aa upstream of the standard start site coupled with a 21 aa substitution for aa 162-277. Over aa 29-175, human and mouse caspase-3 share 87% aa identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Caspase-3 Antibody (AF835)(136)

Publications using AF835

• O Bover, T Justo, PNG Pereira, J Facucho-Ol, JM Inácio, JS Ramalho, IJ Domian, JA Belo Loss of Ccbe1 affects cardiac-specification and cardiomyocyte differentiation in mouse embryonic stem cells PLoS ONE, 2018;13(10):e0205108. 2018 [PMID: 30281646] (Flow,, Mouse)
• M Ouarné, C Bouvard, G Boneva, C Mallet, J Ribeiro, A Desroches-, E Soleilhac, E Tillet, O Peyruchaud, S Bailly BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer J. Exp. Clin. Cancer Res., 2018;37(1):209. 2018 [PMID: 30165893] (IHC-P,, Mouse)
• A López-Muño, FE Nicolás, D García-Mor, AB Pérez-Oliv, MI Navarro-Me, MA Hernández-, A Herrera-Es, S Torres-Mar, RM Ruiz-Vázqu, V Garre, V Mulero An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages Sci Rep, 2018;8(1):12802. 2018 [PMID: 30143654] (IHC - Paraffin embedded,, Zebrafish)
• P Shen, J Chen, M Pan The protective effects of total paeony glycoside on ischemia/reperfusion injury in H9C2 cells via inhibition of the PI3K/Akt signaling pathway Mol Med Rep, 2018;18(3):3332-3340. 2018 [PMID: 30066927] (WB,, Rat)
• M Baek, M Kim, JS Lim, LD Morales, J Hernandez, S Mummidi, S Williams-B, IS Jang, AT Tsin, DJ Kim Epidermal-specific deletion of TC-PTP promotes UVB-induced epidermal cell survival through the regulation of Flk-1/JNK signaling Cell Death Dis, 2018;9(7):730. 2018 [PMID: 29955047] (Human)
• ML Piacentino, ME Bronner Intracellular attenuation of BMP signaling via CKIP-1/Smurf1 is essential during neural crest induction PLoS Biol., 2018;16(6):e2004425. 2018 [PMID: 29949573] (IHC-P,, Chicken)
• I Cohen, D Zhao, C Bar, VJ Valdes, KL Dauber-Dec, MB Nguyen, M Nakayama, M Rendl, WA Bickmore, H Koseki, D Zheng, E Ezhkova PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification Cell Stem Cell, 2018;22(5):726-739.e7. 2018 [PMID: 29727681] (IHC,, Mouse)
• R Barbieri, A Contestabi, MG Ciardo, N Forte, A Marte, P Baldelli, F Benfenati, F Onofri Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice Oncotarget, 2018;9(27):18760-18774. 2018 [PMID: 29721159] (IHC-F,, Mouse)
• E Indersie, KB Hooks, C Capdeviell, M Fabre, N Dugot-Sena, A Desplat, S Lepreux, A Merched, CF Grosset, M Hagedorn Tracking cellular and molecular changes in a species-specific manner during experimental tumor progression in vivo Oncotarget, 2018;9(22):16149-16162. 2018 [PMID: 29662633] (IHC,, Human)
• PLN da Costa, D Wynne, T Fifis, L Nguyen, M Perini, C Christophi The kallikrein-Kinin system modulates the progression of colorectal liver metastases in a mouse model BMC Cancer, 2018;18(1):382. 2018 [PMID: 29618333] (IHC,, Mouse)
• N Antoniou, D Vlachakis, A Memou, E Leandrou, PE Valkimadi, K Melachroin, DB Re, S Przedborsk, WT Dauer, L Stefanis, HJ Rideout A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway Sci Rep, 2018;8(1):3455. 2018 [PMID: 29472595] (ICC,, Mouse)
• JM Povedano, P Martinez, R Serrano, Á Tejera, G Gómez-Lópe, M Bobadilla, JM Flores, F Bosch, MA Blasco Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres Elife, 2018;7(0):. 2018 [PMID: 29378675] (IHC-P,, Mouse)
• D Skuk, JP Tremblay The Process of Engraftment of Myogenic Cells in Skeletal Muscles of Primates: Understanding Clinical Observations and Setting Directions in Cell Transplantation Research Cell Transplant, 2017;26(11):1763-1779. 2017 [PMID: 29338383] (IF,, Primate)
• N Dreyer-And, AS Almeida, P Jensen, M Kamand, J Okarmus, T Rosenberg, SD Friis, A Martínez S, M Blaabjerg, BW Kristensen, T Skrydstrup, JB Gramsberge, HLA Vieira, M Meyer Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells PLoS ONE, 2018;13(1):e0191207. 2018 [PMID: 29338033] (ICC,, Human)
• CA Lyon, H Williams, R Bianco, SJ Simmonds, BA Brown, KS Wadey, FCT Smith, JL Johnson, SJ George Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression Sci Rep, 2017;7(1):17342. 2017 [PMID: 29229950] (IHC,, Human)
• MK Shim, HY Yoon, S Lee, MK Jo, J Park, JH Kim, SY Jeong, IC Kwon, K Kim Caspase-3/-7-Specific Metabolic Precursor for Bioorthogonal Tracking of Tumor Apoptosis Sci Rep, 2017;7(1):16635. 2017 [PMID: 29192289] (WB,, Human)
• M Dezest, M Le Bechec, L Chavatte, V Desauziers, B Chaput, JL Grolleau, P Descargues, C Nizard, S Schnebert, S Lacombe, AL Bulteau Oxidative damage and impairment of protein quality control systems in keratinocytes exposed to a volatile organic compounds cocktail Sci Rep, 2017;7(1):10707. 2017 [PMID: 28878258] (IHC,, Human)
• M Dezest, M Le Bechec, L Chavatte, V Desauziers, B Chaput, JL Grolleau, P Descargues, C Nizard, S Schnebert, S Lacombe, AL Bulteau Oxidative damage and impairment of protein quality control systems in keratinocytes exposed to a volatile organic compounds cocktail Sci Rep, 2017;7(1):10707. 2017 [PMID: 28878258] (IHC-P,, Human)
• M Dezest, M Le Bechec, L Chavatte, V Desauziers, B Chaput, JL Grolleau, P Descargues, C Nizard, S Schnebert, S Lacombe, AL Bulteau Oxidative damage and impairment of protein quality control systems in keratinocytes exposed to a volatile organic compounds cocktail Sci Rep, 2017;7(1):10707. 2017 [PMID: 28878258] (IHC,, Human)
• C Tu, R Xu, M Koleti, J Zoldan Glycogen synthase kinase-3 inhibition sensitizes human induced pluripotent stem cells to thiol-containing antioxidants induced apoptosis Stem Cell Res, 2017;23(0):182-187. 2017 [PMID: 28772167] (Func,, Human)
• DJ Flanagan, N Barker, C Nowell, H Clevers, M Ernst, TJ Phesse, E Vincan Loss of the Wnt receptor Frizzled7 in the gastric epithelium is deleterious and triggers rapid repopulation in vivo Dis Model Mech, 2017;0(0):. 2017 [PMID: 28600348] (IHC,, Mouse)
• F Oozeer, LL Yates, C Dean, CJ Formstone A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin Sci Rep, 2017;7(1):1880. 2017 [PMID: 28500339] (IHC,, Mouse)
• F Cartier, E Indersie, S Lesjean, J Charpentie, KB Hooks, A Ghousein, A Desplat, N Dugot-Sena, V Trézéguet, F Sagliocco, M Hagedorn, CF Grosset New tumor suppressor microRNAs target glypican-3 in human liver cancer Oncotarget, 2017;0(0):. 2017 [PMID: 28476031] (IHC,, Chicken)
• LA Murray, R Dunmore, A Camelo, CA Da Silva, MJ Gustavsson, DM Habiel, TL Hackett, CM Hogaboam, MA Sleeman, DA Knight Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium Respir. Res., 2017;18(1):82. 2017 [PMID: 28468623] (IHC Not Specified,, Mouse)
• AA Chassot, M Le Rolle, M Jourden, MM Taketo, NB Ghyselinck, MC Chaboissie Constitutive WNT/CTNNB1 activation triggers spermatogonial stem cell proliferation and germ cell depletion Dev. Biol., 2017;0(0):. 2017 [PMID: 28456466] (IHC-P,, Mouse)
• JY Jang, SY Choi, I Park, DY Park, K Choe, P Kim, YK Kim, BJ Lee, M Hirashima, Y Kubota, JW Park, SY Cheng, A Nagy, YJ Park, K Alitalo, M Shong, GY Koh VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis EMBO Mol Med, 2017;0(0):. 2017 [PMID: 28438786] (IHC,, Mouse)
• S Grasso, J Chapelle, V Salemme, S Aramu, I Russo, N Vitale, L Verdun di, K Dallaglio, I Castellano, A Amici, G Centonze, N Sharma, S Lunardi, S Cabodi, F Cavallo, A Lamolinara, L Stramucci, E Moiso, P Provero, A Albini, A Sapino, J Staaf, PP Di Fiore, G Bertalot, S Pece, D Tosoni, S Confalonie, M Iezzi, P Di Stefano, E Turco, P Defilippi The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries Nat Commun, 2017;8(0):14797. 2017 [PMID: 28300085] (IHC,, Mouse)
• JC Klein, K Moses, G Zelinskyy, S Sody, J Buer, S Lang, I Helfrich, U Dittmer, CJ Kirschning, S Brandau Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth Nat Commun, 2017;8(0):14600. 2017 [PMID: 28300057] (IHC,, Mouse)
• KR Hughes, LC Harnisch, C Alcon-Gine, S Mitra, CJ Wright, J Ketskemety, D van Sinder, AJ Watson, LJ Hall Bifidobacterium breve reduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD88-dependent manner Open Biol, 2017;7(1):. 2017 [PMID: 28123052] (IHC - Paraffin embedded,, Mouse)
• T Revenco, G Lapouge, V Moers, S Broh‚e, PA Sotiropoul Low Dose Radiation Causes Skin Cancer In Mice And Has A Differential Effect on Distinct Epidermal Stem Cells Stem Cells, 2017;0(0):. 2017 [PMID: 28100039] (IHC - Paraffin embedded,, Mouse)
• Y He, H Huang, C Farischon, D Li, Z Du, K Zhang, X Zheng, S Goodin Combined effects of atorvastatin and aspirin on growth and apoptosis in human prostate cancer cells Oncol. Rep, 2017;37(2):953-960. 2017 [PMID: 28075470] (ICC,, Human)
• Autophagy deficient keratinocytes display increased DNA damage, senescence and aberrant lipid composition after oxidative stress in vitro and in vivo Redox Biol, 2016;11(0):219-230. 2016 [PMID: 28012437] (WB,, Mouse)
• cMyc Regulates the Size of the Premigratory Neural Crest Stem Cell Pool Cell Rep, 2016;17(10):2648-2659. 2016 [PMID: 27926868] (IHC,, Mouse)
• Simon X Liang Proliferation, differentiation and migration of SCA1(-)/CD31(-) cardiac side population cells in vitro and in vivo Int. J. Cardiol., 2016;0(0):. 2016 [PMID: 27847151] (IHC,, Mouse)
• Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations PLoS ONE, 2016;11(11):e0166053. 2016 [PMID: 27832104] (IHC,, Human)
• Karina S Cramer Axonal Cleaved Caspase-3 Regulates Axon Targeting and Morphogenesis in the Developing Auditory Brainstem Front Neural Circuits, 2016;10(0):84. 2016 [PMID: 27822180] (IHC,, Chicken)
• CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex Stem Cell Reports, 2016;7(1):69-79. 2016 [PMID: 27411104] (IHC - PFA fixed,, Mouse)
• M-C De Cian Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary Oncogene, 2016;0(0):. 2016 [PMID: 27270435] (IHC - Paraffin embedded,, Mouse)
• Defining the cellular lineage hierarchy in the interfollicular epidermis of adult skin Nat. Cell Biol., 2016;18(6):619-31. 2016 [PMID: 27183471] (IHC OCT-embedded,, Mouse)
• Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice J Neurosci, 2016;36(17):4758-70. 2016 [PMID: 27122034] (IHC Not Specified,, Mouse)
• F Lorenzi, R Babaei-Jad, J Sheard, B Spencer-De, AS Nateri Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture Mol Ther Methods Clin Dev, 2016;3(0):16024. 2016 [PMID: 27110583] (IHC Paraffin-embedded,, Mouse)
• SR Berkowicz, TJ Featherby, Z Qu, A Giousoh, NA Borg, JI Heng, JC Whisstock, PI Bird Brinp1 (-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density Mol Autism, 2016;7(0):22. 2016 [PMID: 27042284] (IHC - Frozen,, Mouse)
• Jacob F, Yonis A, Cuello F, Luther P, Schulze T, Eder A, Streichert T, Mannhardt I, Hirt M, Schaaf S, Stenzig J, Force T, Eschenhagen T, Hansen A Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue. PLoS ONE, 2016;11(2):e0145937. 2016 [PMID: 26840448] (IHC Paraffin-embedded,, Rat)
• Amelkina O, Zschockelt L, Painer J, Serra R, Villaespesa F, Braun B, Jewgenow K Apoptosis-Related Factors in the Luteal Phase of the Domestic Cat and Their Involvement in the Persistence of Corpora Lutea in Lynx. PLoS ONE, 2015;10(11):e0143414. 2015 [PMID: 26599641] (IHC - paraffin,, Feline)
• JD Aridas, CA McDonald, MC Paton, T Yawno, AE Sutherland, I Nitsos, Y Pham, M Ditchfield, MC Fahey, F Wong, A Malhotra, M Castillo-M, K Bhakoo, EM Wallace, G Jenkin, SL Miller Cord blood mononuclear cells prevent neuronal apoptosis in response to perinatal asphyxia in the newborn lamb J. Physiol. (Lond.), 2016;594(5):1421-35. 2016 [PMID: 26527561] (IHC - Paraffin embedded,, Mouse)
• Wong J, Chen L, Huang Y, Sehba F, Friedel R, Zou H Attenuation of Cerebral Ischemic Injury in Smad1 Deficient Mice. PLoS ONE, 2015;10(8):e0136967. 2015 [PMID: 26317208] (IHC Frozen,, Mouse)
• Quereda V, Porlan E, Canamero M, Dubus P, Malumbres M An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress. Cell Death Differ, 2015;23(3):430-41. 2015 [PMID: 26292757] (IHC Paraffin-embedded,, Mouse)
• Douglas T, Champagne C, Morizot A, Lapointe J, Saleh M The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice. J Immunol, 2015;195(5):2365-73. 2015 [PMID: 26216893] (IHC - Paraffin embedded,, Mouse)
• Levet S, Ouarne M, Ciais D, Coutton C, Subileau M, Mallet C, Ricard N, Bidart M, Debillon T, Faravelli F, Rooryck C, Feige J, Tillet E, Bailly S BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus. Proc Natl Acad Sci U S A, 2015;112(25):E3207-15. 2015 [PMID: 26056270] (IHC Not Specified,, Mouse)
• Sun H, Lou Y, Porturas T, Morrissey S, Luo G, Qi J, Ruan Q, Shi S, Chen Y Exacerbated experimental colitis in TNFAIP8-deficient mice. J Immunol, 2015;194(12):5736-42. 2015 [PMID: 25948814] (IHC Paraffin-embedded,, Mouse)
• Brindle N, Joyce J, Rostker F, Lawlor E, Swigart-Brown L, Evan G, Hanahan D, Shchors K Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer. PLoS ONE, 2015;10(4):e0120348. 2015 [PMID: 25927437] (IHC-OCT embedded,, Mouse)
• Sharma S, Chintala N, Vadrevu S, Patel J, Karbowniczek M, Markiewski M Pulmonary alveolar macrophages contribute to the premetastatic niche by suppressing antitumor T cell responses in the lungs. J Immunol, 2015;194(11):5529-38. 2015 [PMID: 25911761] (Flow,, Mouse)
• Declercq, Annelies, Chiers, Koen, Van den Broeck, Wim, Dewulf, Jeroen, Eeckhaut, Venessa, Cornelissen, Maria, Bossier, Peter, Haesebrouck, Freddy, Decostere, Annemie Interactions of highly and low virulent Flavobacterium columnare isolates with gill tissue in carp and rainbow trout. Vet Res, 2015;46(0):25. 2015 [PMID: 25889257] (IHC Paraffin-embedded,, Fish - Cyprinus carpio (Carp))
• Sesen J, Dahan P, Scotland S, Saland E, Dang V, Lemarie A, Tyler B, Brem H, Toulas C, Cohen-Jonathan Moyal E, Sarry J, Skuli N Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response. PLoS ONE, 2015;10(4):e0123721. 2015 [PMID: 25867026] (IHC - Not specified,, Mouse)
• Scott C, Cha K, Rao R, Liddle C, George J, Gunton J Hepatocyte-specific deletion of ARNT (aryl hydrocarbon Receptor Nuclear Translocator) results in altered fibrotic gene expression in the thioacetamide model of liver injury. PLoS ONE, 2015;10(3):e0121650. 2015 [PMID: 25812120] (IHC Paraffin-embedded,, Mouse)
• Matsuda T, Murao N, Katano Y, Juliandi B, Kohyama J, Akira S, Kawai T, Nakashima K TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus. Nat Commun, 2015;6(0):6514. 2015 [PMID: 25751136] (ICC Fluorescence,, Mouse)
• Luyet C, Schulze K, Sayar B, Howald D, Muller E, Galichet A Preclinical studies identify non-apoptotic low-level caspase-3 as therapeutic target in pemphigus vulgaris. PLoS ONE, 2015;10(3):e0119809. 2015 [PMID: 25748204] (ICC Fluorescence,, Mouse)
• Sawhney S, Hood K, Shaw A, Braithwaite A, Stubbs R, Hung N, Royds J, Slatter T Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a 133p53alpha mimic. PLoS ONE, 2015;10(2):e0116270. 2015 [PMID: 25643152] (IHC Paraffin-embedded,, Mouse)
• Petersson, Monika, Reuter, Karen, Brylka, Heike, Kraus, Andreas, Schettina, Peter, Niemann, Catherin Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours. Nat Commun, 2015;6(0):5874. 2015 [PMID: 25608467] (IHC Not Specified,, Mouse)
• Moyon S, Dubessy A, Aigrot M, Trotter M, Huang J, Dauphinot L, Potier M, Kerninon C, Melik Parsadaniantz S, Franklin R, Lubetzki C Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration. J Neurosci, 2015;35(1):4-20. 2015 [PMID: 25568099] (IHC Frozen,, Mouse)
• Mracsko E, Liesz A, Stojanovic A, Lou W, Osswald M, Zhou W, Karcher S, Winkler F, Martin-Villalba A, Cerwenka A, Veltkamp R Antigen dependently activated cluster of differentiation 8-positive T cells cause perforin-mediated neurotoxicity in experimental stroke. J Neurosci, 2014;34(50):16784-95. 2014 [PMID: 25505331] (ICC Fluorescence,, Mouse)
• Yen T, Alison M, Goodlad R, Otto W, Jeffery R, Cook H, Wright N, Poulsom R Epidermal growth factor attenuates tubular necrosis following mercuric chloride damage by regeneration of indigenous, not bone marrow-derived cells. J Cell Mol Med, 2015;19(2):463-73. 2015 [PMID: 25389045] (IHC - paraffin,, Mouse)
• Fowler, Anna-Kat, Thompson, Jeremy, Chen, Lixia, Dagda, Marisela, Dertien, Janet, Dossou, Katina S, Moaddel, Ruin, Bergeson, Susan E, Kruman, Inna I Differential sensitivity of prefrontal cortex and hippocampus to alcohol-induced toxicity. PLoS ONE, 2014;9(9):e106945. 2014 [PMID: 25188266] (IHC,, Mouse)
• Lindgren G, Ekblad L, Vallon-Christersson J, Kjellen E, Gebre-Medhin M, Wennerberg J Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma. BMC Cancer, 2014;14(0):648. 2014 [PMID: 25182342] (IHC Not Specified,, Mouse)
• Willner D, Cohen-Yeshurun A, Avidan A, Ozersky V, Shohami E, Leker R Short term morphine exposure in vitro alters proliferation and differentiation of neural progenitor cells and promotes apoptosis via mu receptors. PLoS ONE, 2014;9(7):e103043. 2014 [PMID: 25072277] (IHC,, Mouse)
• Park D, Lee J, Park I, Choi D, Lee S, Song S, Hwang Y, Hong K, Nakaoka Y, Makinen T, Kim P, Alitalo K, Hong Y, Koh G Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity. J Clin Invest, 2014;124(9):3960-74. 2014 [PMID: 25061877]
• Deng M, Luo X, Pan L, Yang H, Xie X, Liang G, Huang L, Hu F, Kiernan A, Gan L LMO4 functions as a negative regulator of sensory organ formation in the mammalian cochlea. J Neurosci, 2014;34(30):10072-7. 2014 [PMID: 25057208] (IHC,, Mouse)
• Grahammer F, Haenisch N, Steinhardt F, Sander L, Roerden M, Arnold F, Cordts T, Wanner N, Reichardt W, Kerjaschki D, Ruegg M, Hall M, Moulin P, Busch H, Boerries M, Walz G, Artunc F, Huber T mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proc Natl Acad Sci U S A, 2014;111(27):E2817-26. 2014 [PMID: 24958889] (IHC,, Mouse)
• Wiener Z, Band A, Kallio P, Hogstrom J, Hyvonen V, Kaijalainen S, Ritvos O, Haglund C, Kruuna O, Robine S, Louvard D, Ben-Neriah Y, Alitalo K Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-beta. Proc Natl Acad Sci U S A, 2014;111(21):E2229-36. 2014 [PMID: 24825889] (Flow,, Mouse)
• Kumar L, Chou J, Yee C, Borzutzky A, Vollmann E, von Andrian U, Park S, Hollander G, Manis J, Poliani P, Geha R Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. J Exp Med, 2014;211(5):929-42. 2014 [PMID: 24752297] (IHC,, Mouse)
• Losa D, Kohler T, Bellec J, Dudez T, Crespin S, Bacchetta M, Boulanger P, Hong S, Morel S, Nguyen T, van Delden C, Chanson M Pseudomonas aeruginosa-induced apoptosis in airway epithelial cells is mediated by gap junctional communication in a JNK-dependent manner. J Immunol, 2014;192(10):4804-12. 2014 [PMID: 24733844] (WB,, Human)
• Martinez P, Ferrara-Romeo I, Flores J, Blasco M Essential role for the TRF2 telomere protein in adult skin homeostasis. Aging Cell, 2014;13(4):656-68. 2014 [PMID: 24725274] (IHC Paraffin-embedded,, Mouse)
• Edlund R, Ohyama T, Kantarci H, Riley B, Groves A Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers. Dev Biol, 2014;390(1):1-13. 2014 [PMID: 24650709] (IHC,, Mouse)
• Chu H, Liao Y, Novak J, Hu Z, Merkin J, Shymkiv Y, Braeckman B, Dorovkov M, Nguyen A, Clifford P, Nagele R, Harrison D, Ellis R, Ryazanov A Germline quality control: eEF2K stands guard to eliminate defective oocytes. Dev Cell, 2014;28(5):561-72. 2014 [PMID: 24582807] (IHC,, Mouse)
• Saraga M, Vukojevic K, Krzelj V, Puretic Z, Bocina I, Durdov M, Weber S, Dworniczak B, Ljubanovic D, Saraga-Babic M Mechanism of cystogenesis in nephrotic kidneys: a histopathological study. BMC Nephrol, 2013;15(0):3. 2013 [PMID: 24397250] (IHC - Not specified,, Human)
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• Ling, Xiang, Bao, Feng, Qian, Hao, Liu, Danxia The temporal and spatial profiles of cell loss following experimental spinal cord injury: effect of antioxidant therapy on cell death and functional recovery. BMC Neurosci, 2013;14(0):146. 2013 [PMID: 24238557] (IHC,, Rat)
• Olive V, Sabio E, Bennett M, De Jong C, Biton A, McGann J, Greaney S, Sodir N, Zhou A, Balakrishnan A, Foth M, Luftig M, Goga A, Speed T, Xuan Z, Evan G, Wan Y, Minella A, He L A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. Elife, 2013;2(0):e00822. 2013 [PMID: 24137534] (IHC,, Mouse)
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• Zamli Z, Adams M, Tarlton J, Sharif M Increased chondrocyte apoptosis is associated with progression of osteoarthritis in spontaneous Guinea pig models of the disease. Int J Mol Sci, 2013;14(9):17729-43. 2013 [PMID: 23994836] (IHC,, Guinea Pig)
• Hwang J, Hsu C, Yu W, Liu T, Yang W Diet-induced obesity exacerbates auditory degeneration via hypoxia, inflammation, and apoptosis signaling pathways in CD/1 mice. PLoS ONE, 2013;8(4):e60730. 2013 [PMID: 23637762] (IHC,, Mouse)
• Stott, Simon R, Metzakopian, Emmanoui, Lin, Wei, Kaestner, Klaus H, Hen, Rene, Ang, Siew-Lan Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages. J Neurosci, 2013;33(18):8022-34. 2013 [PMID: 23637192] (IHC OCT-embedded,, Mouse)
• Shakibaei M, Mobasheri A, Lueders C, Busch F, Shayan P, Goel A Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-kappaB and Src protein kinase signaling pathways. PLoS ONE, 2013;8(2):e57218. 2013 [PMID: 23451189] (WB,, Human)
• Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis. Cell Death Differ., 2012;19(11):1761-8. 2012 [PMID: 22555459] (IHC Paraffin-embedded,, Mouse)
• McIntyre A, Patiar S, Wigfield S Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy. Clin. Cancer Res., 2012;18(11):3100-11. 2012 [PMID: 22498007] (IHC,, Human)
• Chen T, Heller E, Beronja S, Oshimori N, Stokes N, Fuchs E An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration. Nature, 2012;485(7396):104-8. 2012 [PMID: 22495305] (IHC Frozen,, Mouse)
• Fuxe J, Tabruyn S, Colton K, Zaid H, Adams A, Baluk P, Lashnits E, Morisada T, Le T, O'Brien S, Epstein DM, Koh GY, McDonald DM Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation. Am. J. Pathol., 2011;178(6):2897-909. 2011 [PMID: 21550017] (IHC,, Mouse)
• Hernandez-Miranda LR, Cariboni A, Faux C, Ruhrberg C, Cho JH, Cloutier JF, Eickholt BJ, Parnavelas JG, Andrews WD Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain. J. Neurosci., 2011;31(16):6174-87. 2011 [PMID: 21508241] (IHC Frozen,, Mouse)
• Perez CJ, Jaubert J, Guenet JL, Barnhart KF, Ross-Inta CM, Quintanilla VC, Aubin I, Brandon JL, Otto NW, DiGiovanni J, Gimenez-Conti I, Giulivi C, Kusewitt DF, Conti CJ, Benavides F Two hypomorphic alleles of mouse Ass1 as a new animal model of citrullinemia type I and other hyperammonemic syndromes. Am. J. Pathol., 2010;177(4):1958-68. 2010 [PMID: 20724589] (IHC Paraffin-embedded,, Mouse)
• Sotiropoulou PA, Candi A, Mascre G, De Clercq S, Youssef KK, Lapouge G, Dahl E, Semeraro C, Denecker G, Marine JC, Blanpain C Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death. Nat. Cell Biol., 2010;12(6):572-82. 2010 [PMID: 20473297] (Flow,, Mouse)
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• Hashizume H, Falcon BL, Kuroda T, Baluk P, Coxon A, Yu D, Bready JV, Oliner JD, McDonald DM Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth. Cancer Res., 2010;70(6):2213-23. 2010 [PMID: 20197469] (IHC,, Human)
• Niessen K, Zhang G, Ridgway JB, Chen H, Yan M ALK1 signaling regulates early postnatal lymphatic vessel development. Blood, 2010;115(8):1654-61. 2010 [PMID: 19903896] (IHC,, Mouse)
• Yawno T, Hirst JJ, Castillo-Melendez M, Walker DW Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain. Neuroscience, 2009;163(3):838-47. 2009 [PMID: 19591903] (IHC Paraffin-embedded,, Ovine)
• Fischer AJ, Scott MA, Ritchey ER, Sherwood P Mitogen-activated protein kinase-signaling regulates the ability of Muller glia to proliferate and protect retinal neurons against excitotoxicity. Glia, 2009;57(14):1538-52. 2009 [PMID: 19306360] (IHC Frozen,, Chicken)
• Borchers MT, Wesselkamper SC, Curull V, Ramirez-Sarmiento A, Sanchez-Font A, Garcia-Aymerich J, Coronell C, Lloreta J, Agusti AG, Gea J, Howington JA, Reed MF, Starnes SL, Harris NL, Vitucci M, Eppert BL, Motz GT, Fogel K, McGraw DW, Tichelaar JW, Orozco-Levi M Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease. J. Clin. Invest., 2009;119(3):636-49. 2009 [PMID: 19197141] (IHC Paraffin-embedded,, Mouse)
• Stedman A, Lecaudey V, Havis E, Anselme I, Wassef M, Gilardi-Hebenstreit P, Schneider-Maunoury S A functional interaction between Irx and Meis patterns the anterior hindbrain and activates krox20 expression in rhombomere 3. Dev. Biol., 2009;327(2):566-77. 2009 [PMID: 19152797] (IHC,, Zebrafish)
• Sozo F, O'Day L, Maritz G, Kenna K, Stacy V, Brew N, Walker D, Bocking A, Brien J, Harding R Repeated ethanol exposure during late gestation alters the maturation and innate immune status of the ovine fetal lung. Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(3):L510-8. 2009 [PMID: 19112099] (IHC Paraffin-embedded,, Ovine)
• Michaelis M, Bliss J, Arnold SC, Hinsch N, Rothweiler F, Deubzer HE, Witt O, Langer K, Doerr HW, Wels WS, Cinatl J Cisplatin-resistant neuroblastoma cells express enhanced levels of epidermal growth factor receptor (EGFR) and are sensitive to treatment with EGFR-specific toxins. Clin. Cancer Res., 2008;14(20):6531-7. 2008 [PMID: 18927293] (ICC,, Human)
• Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Yla-Herttuala S, Wedge SR, Jurgensmeier JM, Alitalo K The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis. Cancer Res., 2008;68(12):4754-62. 2008 [PMID: 18559522] (ICC,, Human)
• Boncoeur E, Roque T, Bonvin E, Saint-Criq V, Bonora M, Clement A, Tabary O, Henrion-Caude A, Jacquot J Cystic fibrosis transmembrane conductance regulator controls lung proteasomal degradation and nuclear factor-kappaB activity in conditions of oxidative stress. Am. J. Pathol., 2008;172(5):1184-94. 2008 [PMID: 18372427] (IHC Paraffin-embedded,, Mouse)
• Siegl-Cachedenier I, Flores I, Klatt P, Blasco MA Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres. J. Cell Biol., 2007;179(2):277-90. 2007 [PMID: 17954610] (IHC Paraffin-embedded,, Mouse)
• Benosman S, Gross I, Clarke N, Jochemsen AG, Okamoto K, Loeffler JP, Gaiddon C Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis. Cell Death Differ., 2007;14(12):2047-57. 2007 [PMID: 17823617] (ICC,, Mouse)
• Bond JA, Gescher AJ, Verschoyle RD, Lemoine NR, Errington R, Wiltshire M, Smith PJ, Wynford-Thomas D Cytotoxic action of phorbol esters on human pancreatic cancer cells. Int. J. Cancer, 2007;121(7):1445-54. 2007 [PMID: 17582609] (ICC,, Human)
• Wu F, Chiocca S, Beck WT, Mo YY Gam1-associated alterations of drug responsiveness through activation of apoptosis. Mol. Cancer Ther., 2007;6(6):1823-30. 2007 [PMID: 17575111] (ICC,, Human)
• Yawno T, Yan EB, Walker DW, Hirst JJ Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep. Neuroscience, 2007;146(4):1726-33. 2007 [PMID: 17449186] (IHC Paraffin-embedded,, Ovine)
• Blouw B, Haase VH, Song H, Bergers G, Johnson RS Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene. Oncogene, 2007;26(31):4531-40. 2007 [PMID: 17297464] (IHC,, Mouse)
• Xue M, Campbell D, Jackson CJ Protein C is an autocrine growth factor for human skin keratinocytes. J. Biol. Chem., 2007;282(18):13610-6. 2007 [PMID: 17293597] (WB,, Human)
• do Vale A, Costa-Ramos C, Silva DS, Macedo PM, Fernandes R, Sampaio P, Dos Santos NM, Silva MT Cytochemical and ultrastructural study of anoikis and secondary necrosis in enterocytes detached in vivo. Apoptosis, 2007;12(6):1069-83. 2007 [PMID: 17245641] (IHC Paraffin-embedded,, Fish)
• Fessing MY, Sharova TY, Sharov AA, Atoyan R, Botchkarev VA Involvement of the Edar signaling in the control of hair follicle involution (catagen). Am. J. Pathol., 2006;169(6):2075-84. 2006 [PMID: 17148670] (IHC Fresh,, Mouse)
• Blanpain C, Lowry WE, Pasolli HA, Fuchs E Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev., 2006;20(21):3022-35. 2006 [PMID: 17079689] (IHC,, Mouse)
• Harris LK, Keogh RJ, Wareing M, Baker PN, Cartwright JE, Aplin JD, Whitley GS Invasive trophoblasts stimulate vascular smooth muscle cell apoptosis by a fas ligand-dependent mechanism. Am. J. Pathol., 2006;169(5):1863-74. 2006 [PMID: 17071607] (IHC Frozen,, Human)
• Rodriguez-Guzman M, Montero JA, Santesteban E, Ganan Y, Macias D, Hurle JM Tendon-muscle crosstalk controls muscle bellies morphogenesis, which is mediated by cell death and retinoic acid signaling. Dev. Biol., 2007;302(1):267-80. 2007 [PMID: 17070795] (IHC,, Chicken)
• Hendriksen PJ, Dits NF, Kokame K, Veldhoven A, van Weerden WM, Bangma CH, Trapman J, Jenster G Evolution of the androgen receptor pathway during progression of prostate cancer. Cancer Res., 2006;66(10):5012-20. 2006 [PMID: 16707422] (ICC,, Human)
• Kossmehl P, Kurth E, Faramarzi S, Habighorst B, Shakibaei M, Wehland M, Kreutz R, Infanger M, J Danser AH, Grosse J, Paul M, Grimm D Mechanisms of apoptosis after ischemia and reperfusion: role of the renin-angiotensin system. Apoptosis, 2006;11(3):347-58. 2006 [PMID: 16538381] (WB,, Porcine)
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Reviews for Caspase-3 Antibody (AF835) (7)

Average Rating: 4.9

(Based on 7 reviews)

We have 7 reviews tested in 2 species: Mouse, Other.

reviewed by: Anonymous WB Mouse 01/09/2015

Summary

• Application: Western Blot
• Sample Tested: See PMID 23374352
• Species: Mouse

Blocking

• Blocking Details: See PMID 23374352

Details

• Detection Notes: See PMID 23374352

Comments

• Comments: Published: See PMID 23374352Independent review from antibodyresource.com

reviewed by: Anonymous IHC-P Mouse 01/09/2015

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: See PMID 20522641
• Species: Mouse

reviewed by: Anonymous IHC-P Mouse 01/09/2015

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: See PMID 22897852
• Species: Mouse

reviewed by: Anonymous IHC-P Other 01/09/2015

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: See PMID 22438018
• Species: Other

reviewed by: Anonymous IF Mouse 01/09/2015

Summary

• Application: Immunofluorescence
• Sample Tested: See PMID 23532769
• Species: Mouse

Blocking

• Blocking Details: See PMID 23532769

Details

• Detection Notes: See PMID 23532769

Comments

• Comments: Published: See PMID 23532769Independent review from antibodyresource.com

reviewed by: Anonymous IF Mouse 01/09/2015

Summary

• Application: Immunofluorescence
• Sample Tested: See PMID 19226508
• Species: Mouse

Blocking

• Blocking Details: See PMID 19226508

Details

• Detection Notes: See PMID 19226508

Comments

• Comments: PublisheD: See PMID 19226508Independent review from antibodyresource.com

reviewed by: Anonymous IHC-P Mouse 01/09/2015

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: See PMID 23742999
• Species: Mouse

Bioinformatics

• Gene Symbol: CASP3
• Uniprot:
  • P42574 ()