ATG16L1 Products

Antibodies
ATG16L1 Antibody
ATG16L1 Antibody
NBP2-15504
Species: Hu, Mu, Rt, Po, Bv
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
ATG16L1 Overexpression Lysate ...
ATG16L1 Overexpression Lysate
NBP2-06180
Species: Hu
Applications: WB
Proteins
ATG16L1 Antibody Blocking Pep ...
ATG16L1 Antibody Blocking Peptide
NB110-82384PEP
Species: Mu
Applications: AC
ATG16L1 Antibody Blocking Pep ...
ATG16L1 Antibody Blocking Peptide
NB110-60928PEP
Species: Hu
Applications: AC
Recombinant Human ATG16L1 GST ...
Recombinant Human ATG16L1 GST (N-T...
H00055054-P01
Species: Hu
Applications: WB, ELISA, PA, AP

Description

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The APG12-APG5-APG16L complex is essential for the elongation of autophagic isolation membranes. This complex initially associates in uniform distribution with small vesicle membranes. During membrane elongation, the complex partitions, with a great concentration building on the outer side of the isolation membrane. Upon completion of the formation of the autophagosome, the APG12-APG5-APG16L dissociates from the membrane. There are 5 isoforms of this protein (in human), with theoretical molecular weights ranging from ~19-68 kDa.

Mutations in the ATG16L1 proitein have been associated with Crohn's disease.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Mouse
Product By Gene ID 55054
Alternate Names
  • ATG16L
  • APG16-like 1
  • ATG16 autophagy related 16-like (S. cerevisiae)
  • WD repeat domain 30
  • APG16 autophagy 16-like (S. cerevisiae)
  • autophagy-related protein 16-1
  • IBD10
  • APG16L beta
  • WDR30
  • FLJ10035
  • FLJ22677
  • ATG16A
  • APG16LFLJ10828
  • FLJ00045
  • ATG16 autophagy related 16-like 1 (S. cerevisiae)

Research Areas for ATG16L1

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Cancer
Cell Biology
Neurodegeneration
Neuroscience
Phospho-Specific
Tumor Suppressors
Ubiquitin Proteasome Pathway

PTMs for ATG16L1

Learn more about PTMs related to ATG16L1.

Phosphorylation

Bioinformatics Tool for ATG16L1

Discover related pathways, diseases and genes to ATG16L1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related ATG16L1 Blog Posts

Check out the latest blog posts on ATG16L1.
Liver ASK1 activates autophagy to protect against hepatic fat accumulation, non-alcoholic steatohepatitis and fibrosis
By Jamshed Arslan, Pharm. D., PhD. The most common chronic liver disorder worldwide is non-alcoholic fatty liver disease (NAFLD). This obesity-linked disorder can manifest as hepatic fat accumulation (steatosis) wit...    Read more.
ATG16L1 - a key player in the development of the autophagosome
Like apoptosis, autophagy is a highly regulated physiologic process that involves cellular degradation and recycling of organelles and macromolecules. Autophagy is a survival mechanism induced by states of stress, starvation, and infection. A do...    Read more.
Read more ATG16L1 related blogs.