ATG12 Products

ATG12 Antibody
ATG12 Antibody
Species: Hu, Mu, Rt, Pm
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
ATG12 Antibody (628902)
ATG12 Antibody (628902)
Species: Hu, Mu
Applications: WB, ICC/IF
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
ATG12 Antibody (166)
ATG12 Antibody (166)
Species: Hu, Mu
Applications: WB, ICC/IF
Host: Mouse Monoclonal
ATG12 Overexpression Lysate
ATG12 Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Human ATG12 GST ( ...
Recombinant Human ATG12 GST (N-Ter...
Species: Hu
Applications: WB, ELISA, PA, AP
Recombinant Human ATG12 GST ( ...
Recombinant Human ATG12 GST (N-Ter...
Species: Hu
Applications: WB, ELISA, PA, AP
ATG12 Antibody Blocking Pepti ...
ATG12 Antibody Blocking Peptide
Species: Hu
Applications: AC


The ATG12 gene codes a ubiquitin-like protein ATG12 that in isoform 1 is 140 amino acids long at 15 kDA and in isoform 2 is 74 amino acids long at 7 kDA. This protein is critical for autophagy (bulk protein degradation) as it is the human homolog of a yeast protein that participates in autophagy. ATG12 participates in the immune system, apoptosis and autophagy, protein stability, negative regulators of RIG-I/MDA5 signaling, and glucose/energy metabolism. It is known to interact with various genes such as HIST1H2BF, HIST1H2BE, HIST1H2BI, HIST1H2BG, and HIST1H2BC. ATG12 has been researched regarding its role in leukemia, lung cancer, myositis, retinitis, carcinoma, colorectal cancer, and myelodysplastic syndrome.


Entrez Human
Uniprot Human
Product By Gene ID 9140
Alternate Names
  • APG12-like
  • APG12 autophagy 12-like (S. cerevisiae)
  • ubiquitin-like protein ATG12
  • Apg12 (autophagy 12, S. cerevisiae)-like
  • yeast) homolog
  • Autophagy-related protein 12
  • APG12HAPG12
  • FBR93
  • ATG12 autophagy related 12 homolog (S. cerevisiae)

Research Areas for ATG12

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PTMs for ATG12

Learn more about PTMs related to ATG12.


Bioinformatics Tool for ATG12

Discover related pathways, diseases and genes to ATG12. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related ATG12 Blog Posts

Check out the latest blog posts on ATG12.
Liver ASK1 activates autophagy to protect against hepatic fat accumulation, non-alcoholic steatohepatitis and fibrosis
By Jamshed Arslan, Pharm. D., PhD. The most common chronic liver disorder worldwide is non-alcoholic fatty liver disease (NAFLD). This obesity-linked disorder can manifest as hepatic fat accumulation (steatosis) wit...    Read more.
Best genes to knockout to control autophagic flux
By Christina Towers, PhD Autophagy flux: Basic principlesAutophagic flux is defined as the amount of cellular material degraded and recycled through the process of autophagy, whereby cells break down and disca...    Read more.
The LC3 A, B, C’s and 1, 2, 3’s
By Christina Towers, PhD Autophagy is a catabolic process used to breakdown and recycle damaged proteins and organelles. It is a multistep process that, in its simplest form, consists of 4 steps: initiation, phago...    Read more.
Animal Models to Study Autophagy
By Christina Towers, PhD What is autophagy?Autophagy is the catabolic process that degrades cytoplasmic material via the lysosome. The process of macroautophagy was originally characterized in yeast, where the...    Read more.
Autophagy independent roles of the core ATG proteins
By Christina Towers, PhD. Autophagy and ATG ProteinsAutophagy is a nutrient recycling process that cells use to fuel metabolism, particularly in response to nutrient deprivation.  It is critical for removal of dam...    Read more.
WIPI1 - An essential regulator of early autophagosome assembly
WD repeat domain phosphoinositide-interacting protein 1 (WIPI) is involved in the lysosomal degradation of cytoplasmic components during starvation-induced autophagy. WIPI1 is a seven bladed beta-propeller protein that provides a scaffold for the ...    Read more.
ATG4C - A regulator of the early steps of autophagosome assembly
Autophagy is an important cellular process that maintains homeostasis by degrading and recycling damaged proteins and organelles. Autophagy receptors, such as p62/SQSTM1, recognize these intracellular cargo and mediate their engulfment by the doubl...    Read more.
ATG16L2 - An autophagy-related protein with unknown functions
Autophagy is a process by which cells degrade and recycle damaged organelles or misfolded proteins. These various cargo are engulfed in a double-membrane structure called the autophagosome. The autophagosome then fuses with the lysosome to facilit...    Read more.
ATG4D - A regulator of autophagy and apoptosis
Autophagy is an essential cellular process whereby damaged proteins and organelles are degraded and recycled. Autophagy, while happening constantly at a basal level, is tightly regulated and can be further induced under cellular stress. One of the...    Read more.
ATG4B - a cysteine protease involved in autophagosome elongation
Autophagy can be broken down into 4 main stages: phagophore nucleation, autophagosome elongation, autophagosome docking and fusion with a lysosome, and vesicle breakdown and degradation. ATG4B is one of four ATG4 homologs (ATG4A, ATG4B, ATG4C, and...    Read more.
ATG16L1 - a key player in the development of the autophagosome
Like apoptosis, autophagy is a highly regulated physiologic process that involves cellular degradation and recycling of organelles and macromolecules. Autophagy is a survival mechanism induced by states of stress, starvation, and infection. A do...    Read more.
ATG5 - an essential regulator of autophagosome assembly
Autophagy is important for the removal of damaged organelles or proteins as well as for the regulation of cellular homeostasis in response to stress. Proteins or organelles that are targeted for degradation are engulfed in a double-membrane structu...    Read more.
ATG7 - an E1 enzyme for the ubiquitin-like autophagy proteins
Autophagy is an essential cellular process that maintains homeostasis through the degradation and recycling of cytoplasmic organelles and macromolecules. Substrates targeted for autophagy are engulfed in a double-membrane structure called the auto...    Read more.
ATG12 - a ubiquitin-like protein essential for autophagosome assembly
Atg12 is a ubiquitin-like protein that plays an essential role in cellular homeostasis by regulating the degradation and recycling of cytoplasmic organelles and macromolecules. Atg12 is one of two ubiquitin-like protein systems that is required du...    Read more.
LC3/LC3B - measuring autophagosome formation and autophagic flux
Microtubule-associated protein-1 light chain 3 (LC3/LC3B) is a ubiquitin-like protein involved in the formation of the autophagosome. It is homologous to the yeast Atg8 protein. Autophagosomes are important for the degradation and recycling of intr...    Read more.
Breakdown: Interpreting LC3 Antibody WB Results
In rodents, MAP1LC3 (Microtubule-associated protein 1 light chain 3) is expressed in the renal visceral epithelial cells, or podocytes. LC3 antibody analysis has shown the protein accumulates in its membrane-bound form, LC3II, following conversio...    Read more.
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