Cancer

Stemness for Surviving Hypoxia: TGF-beta/Smad Signaling in Multiple Myeloma

Marked for Deletion: Parkin Ubiquitinylates HIF-1α to Stop Cancer

Parkin Ubiquitinylates HIF-1 alpha

By Jamshed Arslan Pharm.D.

Chaperone Mediated Autophagy (CMA) does it all!

From Then ‘till Now: The History of Autophagy and Cancer Research

Friends become Foes: Molecular Chaperons, Hsp70 and Hsp90, Cause Muscle Wasting in Cancers

Exosome research

By Jamshed Arslan Pharm.D.

Breast Cancer Survives by Releasing Self-Serving Glutamate

Autophagy: Pro or Anti-tumorigenic? And the role of epigenetics in this debate

By Christina Towers, PhD

Novel Insights into Hypoxia Induced AKT Signaling

Hypoxia is a common feature of most tumors and is a product of rapid cell growth and poor vascularization1. When oxygen availability is low in the tumor environment, the hypoxia inducing transcription factors (HIFs) regulate a variety of signaling programs that can affect the balance between tumor cell apoptosis2 and autophagy3.  In normoxia, HIFs are bound by the von Hippel-Lindau protein (VHL) in the cytosol where it is degraded by the proteasome, however, under hypoxia HIFs are translocated to the nucleus where they activate survival signals.

Ovarian Cancer Infographic

September is Ovarian Cancer Awareness month and brings to focus a cancer that is estimated to be diagnosed in over 21,000 women in the US in 2014 (1). Ovarian cancer often goes undiagnosed due to the lack of symptoms until it metastasized into the pelvic or abdominal areas. Treatment typically requires surgery and chemotherapy.

Ovarian cancer infographic

 

By: Lisa Ikariyama; Design: Kim Mesman

BRCA1 - A Critical Tumor Suppressor Gene in Women

Breast cancer 1, early onset (BRCA1) is a well-known tumor suppressor gene that was originally discovered due to its link with early-onset breast and ovarian cancer in women. The BRCA1 protein contains the following domains: RING finger, RAD51-interaction, and BRCT (BRCA1 C-terminus). The N-terminus RING domain enables binding to several proteins - including BARD1 (BRCA1-associated RING domain protein) - allowing the formation of heterodimers. The RING finger is important for tumor suppressor activity. The RAD51-interaction domain is involved in DNA double-stranded break (DSB) repair.

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