YAP1: Novus Biologicals

Transcriptional co-activators Yap1 and Taz control growth and development

Schematic of Hippo signaling pathway highlighting Yap and Taz proteins.

By Jamshed Arslan, Pharm D, PhD

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YAP1 - a transcription co-activator and the downstream target of Hippo pathway

YAP1 (Yes-associated protein 1) is a transcriptional co-activator which acts as a major effector of Hippo signaling pathway that regulates organ size/ tissue homeostasis and cell proliferation, and is an established oncogene (1). Hippo signaling activation results in the phosphorylation mediated inactivation of YAP1, and restriction of YAP1’s transcriptional activity is the principal mechanism of growth and tumor suppression by Hippo pathway.

Tags:

Yes-associated protein 1

YAP1

Apoptosis

Cell Proliferation

Read more about YAP1 - a transcription co-activator and the downstream target of Hippo pathway
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