VEGF

mTOR Signaling and the Tumor Microenvironment

Chemotherapy-induced metastasis: An unexpected foe?

Getting Physical: Link between Lipid Metabolism and Hypoxia Target Genes

Autophagy Mechanisms

By Jamshed Arslan Pharm.D.

Marked for Deletion: Parkin Ubiquitinylates HIF-1α to Stop Cancer

Parkin Ubiquitinylates HIF-1 alpha

By Jamshed Arslan Pharm.D.

Potential therapies for human ovarian cancer surrounding the PI3K/AKT/mTOR pathway

Mammalian target of Rapamycin (mTOR) is a serine/threonine kinase that regulates cell growth, proliferation, motility and survival.

The role of HIF-2 alpha in the progression and therapy of clear cell renal cell carcinoma

HIF-2 alpha, also known as hypoxia-inducible factor 2, endothelial PAS domain protein-1, and member of PAS superfamily 2 is part of the HIF family of proteins.  The HIF family is composed of HIF-1, HIF-2 and HIF-3, where HIF-2 is a dimeric protein that consists of an alpha and beta subunit.HIF-2 alphais activated in the presence of oxygen deprivation, or hypoxia, via prolyl hydroxylase-domain enzymes (PHD

The application of CD31/Pecam-1 (MEC 7.46) in breast cancer research

CD31/PECAM-1, or platelet endothelial cell adhesion molecule 1, is a 130-kDa glycoprotein expressed on vascular and hematopoietic cells.  Depending on the cell type, CD31/PECAM-1 expression can be largely localized to cell junctions, playing a role in cell adhesion.  Aside from its role in cellular adhesion, CD31/PECAM-1 is also a large player in a variety of signaling pathways, such as angiogenesis, cell migration, leukocyte transmigration and more.  Specifically, the association and indication of angiogenesis in breast cancer is of interest, given that extensive research shows an

The dynamic use of a PCNA antibody in fish, porcine and primate species

Proliferating cell nuclear antigen (PCNA) plays a crucial role in nucleic acid metabolism as it pertains to DNA replication and repair.  Most noted for its activation of subunits of DNA polymerase, it has also been found to interact with cell-cycle progression proteins.  Modifications of PCNA as a result of cellular response put PCNA in a pivotal position with DNA replication, DNA damage, and chromatin structure and function.  In response to DNA damage, PCNA is ubiquitinated and becomes part of the RAD-6 dependent DNA repair pathway, where it acts as a substrate with a variety of p

The role of HIF-1 Alpha signaling in the retina under hypoxic conditions

Hypoxia inducible factor 1 (HIF-1) is a protein that plays an essential role in hypoxia, or low levels of cellular oxygen.

Using SCP3/SYCP3 Antibodies as Meiosis Markers in Gametogenesis and DNA Repair Studies

The synaptonemal complex (SC) is a protein structure that forms during the synapsis of homologous chromosomes during meiosis. This structure is involved in the processes of chromosome synapsis, genetic recombination and subsequent chromosome segregation, and is essential for gametogenesis.

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