VEGF

Understanding ‘Y’ in Breast Cancer: Crucial Role of DNA/RNA-binding Protein YB-1 in the Development, Pre-Invasive, and Metastatic Phases

Detecting HIF alpha and beyond: Best controls for hypoxia Western blot analysis

Neurovascular signaling for repair enhances brain metastasis

mTOR Signaling and the Tumor Microenvironment

Chemotherapy-induced metastasis: An unexpected foe?

Getting Physical: Link between Lipid Metabolism and Hypoxia Target Genes

Autophagy Mechanisms

By Jamshed Arslan Pharm.D.

Marked for Deletion: Parkin Ubiquitinylates HIF-1α to Stop Cancer

Parkin Ubiquitinylates HIF-1 alpha

By Jamshed Arslan Pharm.D.

Potential therapies for human ovarian cancer surrounding the PI3K/AKT/mTOR pathway

Mammalian target of Rapamycin (mTOR) is a serine/threonine kinase that regulates cell growth, proliferation, motility and survival.

The role of HIF-2 alpha in the progression and therapy of clear cell renal cell carcinoma

HIF-2 alpha, also known as hypoxia-inducible factor 2, endothelial PAS domain protein-1, and member of PAS superfamily 2 is part of the HIF family of proteins.  The HIF family is composed of HIF-1, HIF-2 and HIF-3, where HIF-2 is a dimeric protein that consists of an alpha and beta subunit.HIF-2 alphais activated in the presence of oxygen deprivation, or hypoxia, via prolyl hydroxylase-domain enzymes (PHD

The application of CD31/Pecam-1 (MEC 7.46) in breast cancer research

CD31/PECAM-1, or platelet endothelial cell adhesion molecule 1, is a 130-kDa glycoprotein expressed on vascular and hematopoietic cells.  Depending on the cell type, CD31/PECAM-1 expression can be largely localized to cell junctions, playing a role in cell adhesion.  Aside from its role in cellular adhesion, CD31/PECAM-1 is also a large player in a variety of signaling pathways, such as angiogenesis, cell migration, leukocyte transmigration and more.  Specifically, the association and indication of angiogenesis in breast cancer is of interest, given that extensive research shows an

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