Article Review: Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury

Traumatic brain injury (TBI) currently contributes to nearly 30% of all injury deaths in the United States.  Characterized by an abrasive head injury that interrupts normal brain function, TBI can range from mild to severe.  Mild symptoms can present themselves as excessive tiredness, difficulty concentrating and lack of clear thinking.  Severe cases of TBI are hallmarked by unusual behavior, seizures and loss of consciousness.  Research has shown that on a molecular level TBI triggers various mechanisms of cell death alongside attempted tissue recovery, therefore Choi et al sought

The role of HIF-2 alpha in the progression and therapy of clear cell renal cell carcinoma

HIF-2 alpha, also known as hypoxia-inducible factor 2, endothelial PAS domain protein-1, and member of PAS superfamily 2 is part of the HIF family of proteins.  The HIF family is composed of HIF-1, HIF-2 and HIF-3, where HIF-2 is a dimeric protein that consists of an alpha and beta subunit.HIF-2 alphais activated in the presence of oxygen deprivation, or hypoxia, via prolyl hydroxylase-domain enzymes (PHD

The use of a GFP antibody for research applications in transgenic C. elegans, GFP tagged yeast and porcine model

GFP, or green fluorescent protein, is a chemiluminescent protein derived from Aequorea jellyfish that was first discovered by Osamu Shimomura.  It was soon after established that the emission spectra of GFP was right around 509nm, or the ultraviolet color range.  The GFP gene is often used to form expression constructs in order to closely follow protein behavior, cellular differentiation, protein localization and more.  The following articles employed a GFP antibody in conjunction with various other GFP construct techniques to strengthe

VEGF: Vascular endothelial growth factor

VEGF is homodimeric, disulfide-linked glycoprotein cytokine that serves as the ligand for FLT1 (VEGFR-1 receptor) and FLK1 (VEGFR-2 receptor) tyrosine kinases. It is a key modulator of physiological angiogenesis, vasculogenesis, and endothelial cell growth during basic developmental processes such as embryogenesis, skeletal growth, and reproductive functions.

TLR2 - I can recognize many foreign pathogens!

TLR2 is a member of the broad family of Toll-like receptors (TLR) that play an important role in pathogen recognition and innate immunity.

MyD88 Antibodies for IL Signaling and Immunity Research

The myeloid differentiation protein MyD88 (myeloid differentiation primary response protein) was originally identified and characterized as a primary upregulated response gene in interleukin-6 mediated myeloid differentiation.

"Get the skinny" on Adiponectin & Leptin Antibodies