The NLRP3 Inflammasome: Macrophage Activator & Pathology Driver

Pattern recognition receptors (PRR) expression and function in endothelial cells

Liver ASK1 activates autophagy to protect against hepatic fat accumulation, non-alcoholic steatohepatitis and fibrosis

Gut-brain axis: microbiota influence behavior and mental well-being

PAMPs and DAMPs: What is the same and what is different about these molecules?

iNOS: The Nitric Oxide Boss

Nitric oxide (NO) is an inorganic, gaseous, and reactive free radical that acts as a biologic mediator in processes such as neurotransmission, vasorelaxation, and cytotoxicity. In addition, it has antimicrobial and anti-tumoral activities. NO production is mediated by members of the nitric oxide synthase (NOS) family. The NOS enzyme catalyzes the oxidization of L-arginine into L-citrulline and NO.  Several subtypes have been identified: two constitutive isoforms (type I brain/neuronal NOS, and type III endothelial) and one inducible isoform (iNOS, or type II).

MyD88 Antibodies for IL Signaling and Immunity Research

The myeloid differentiation protein MyD88 (myeloid differentiation primary response protein) was originally identified and characterized as a primary upregulated response gene in interleukin-6 mediated myeloid differentiation.