Innate Immunity

The NLRP3 Inflammasome: Macrophage Activator & Pathology Driver

Synthetic Biotic Medicine as Immunotherapy Against Cancer: Evidence From Arginine-Producing Engineered Bacteria

Immune Cell Metabolic Flux Influences Type I Diabetes

Early T cell response is associated with mild COVID-19 and rapid SARS-CoV-2 clearance

Approved COVID-19 Vaccines: Delivery of Nucleic Acid Cargo and Immune Response

Pattern recognition receptors (PRR) expression and function in endothelial cells

Repurposing FDA-approved drugs to combat the rise of antibiotic resistance

The inflammasome: an inflammation-initiating machine, Novus Biologicals

You complete me: Natural killer cells need TGF-beta inhibition to effectively combat cancers

CD16 - Find me on macrophages, neutrophils and NK cells

CD16 is a lymphocyte Fc gamma type III low-affinity receptor for IgG and is represented by two similar genes, CD16A (Fc gamma RIII A) and CD16B (Fc gamma RIIIB). CD16A exists as a heterooligomeric polypeptide-anchored form in macrophages and NK cells. CD16B exists as a monomeric glycosylphosphatidylinositol (GPI)-anchored form in neutrophils. CD16 binds IgG in the form of immune complexes or free antibody. It exhibits preferential binding to IgG1 and IgG3 isotypes, with minimal binding of IgG2 and IgG4.