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Immunotherapy

NPC1: A Potential Target For Triple-Negative Breast Cancer

Immunocytochemical analysis of NPC1 in HeLa cells.

By Natalia Gurule, PhD

 

Tags: 
Breast Cancer
Cancer
Cholesterol
EMT
Immunotherapy
Lysosome
Mitochondria
Triple-Negative Breast Cancer
TNBC
BRCA1
ErbB2/Her2
Niemann-Pick C1
PARP
Natalia Gurule

Hypoxia-Dependent CAR Stabilizing Construct in T cells Improves Solid Tumor Targeting and Efficacy

Banner image showing a chimeric antigen receptor (CAR) T cell.

By Victoria Osinski, PhD

Tags: 
Cancer
Chimeric Antigen Receptor
CAR-T
Hypoxia
immunology
Immunotherapy
Oxygen
T Cells
Tumor
Tumor Microenvironment
EGFR
ErbB2/Her2
ErbB3/Her3
ErbB4/Her4
HIF-1 alpha
Victoria Osinski

Synthetic Biotic Medicine as Immunotherapy Against Cancer: Evidence From Arginine-Producing Engineered Bacteria

3D banner image showing example of pathogenic bacteria.

By Jamshed Arslan, Pharm D, PhD

Tags: 
Bacteria
Cancer
Cancer Research
Checkpoint Blockade
Checkpoint Inhibitors
immunology
Immuno-oncology
Immunotherapy
Innate Immunity
L-arginine
T Cells
Tumor
ARG-2
CD4
CD8
PD-1
PD-L1
Jamshed Arslan

Harnessing Natural Killer Cell Activity for Anti-Tumor Immunotherapy

Banner image showing the workflow for Natural Killer (NK) cells.

By Victoria Osinski, PhD

Tags: 
Natural Killer Cell
NK Cell
Cancer
immunology
Immuno-oncology
Immunotherapy
CD8
MHC Class I
NKG2A/CD159a/KLRC1
NKG2C/CD159c/KLRC2
NKG2D/CD314
NKG2E/KLRC3
KLRC4
NKG2H
DAP12
Killer Cell Immunoglobulin-like Receptor
CD7
CD19
Siglec-3/CD33
MUC1
ErbB2/Her2
MICA
MICB
ULBP
HDAC
HLA G
KIR2DL4/CD158d
Victoria Osinski

Success of combined IL-10 and IL-12 therapy in colon cancer depends on IFN-gamma and gut barrier integrity

IL10 receptor alpha expression in human colon carcinoma, IHC

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
Cancer
Colorectal Cancer
Colon Cancer
Immunotherapy
immunology
T helper
Cytotoxic T cells
IL-10
IL-12
IFN-gamma
IL-10 R alpha
CD4
CD8
IL-17
Th17
ROR gamma t
Jamshed Arslan

Advancing CAR T Therapies with CRISPR/Cas9

Expression of CD4 and CD8 in peripheral blood mononuclear cells ICC

By Victoria Osinski

Tags: 
CRISPR-Cas9
Lymphocytes
T Cells
Tumor
Cancer
Cancer Research
CAR-T
Immunotherapy
Immuno-oncology
immunology
CRISPR/Cas9

Adenosine Inhibits T cell Tumor Infiltration: KCa3.1, a New Anticancer Target

CD8 alpha antibody, ICC

By Yoskaly Lazo-Fernandez, PhD

Tags: 
Cancer
T Cells
Immunotherapy
immunology
Hypoxia
Adenosine A2a R
CD39/ENTPD1
5'-Nucleotidase/CD73