Sox2

Application Focus: New Methods for iPSC Differentiation, Inducing a Mammary Fate

Stemness for Surviving Hypoxia: TGF-beta/Smad Signaling in Multiple Myeloma

KLF4 as a transcription factor in stem cell differentiation

Krüppel-like factors (KLFs) are evolutionarily conserved zinc finger transcription factors that play a role in cell differentiation, proliferation, and pluripotency.

SOX2 - a stem cell transcription factor

The SOX gene family encodes a group of highly conserved transcription factors defined by the presence of a conserved high motility group (HMG) DNA-binding domain. They are involved in embryonic development regulation and cell fate determination. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. This bending opens the DNA helix for some distance, which may affect the binding and interactions of other transcription factors.

SOX2: an Important Stem Cell Transcription Factor

SOX2 is a transcription factor that is expressed by self-renewing and multipotent stem cells of the embryonic neuroepithelium. Sox-2 was found to be expressed by dividing neural progenitor cells. Constitutive expression of SOX2 has also been shown to inhibit neuronal differentiation and results in the maintenance of progenitor characteristics.

Sox2 and Oct4: Roles in Embryonic Stem Cell Pluripotency

Embryonic stem (ES) cells are cells derived from the inner cell mass of the blastocyst, an early-stage embryo. ES cells are distinguished from other cells due to their pluripotency, which is the ability to differentiate into any different type of cell in the body, and also their capability of propagating indefinitely. These two factors make embryonic stem cells valuable tools in the scientific community, especially in regenerative medicine.

An Unlikely Pairing: The SOX2 Antibody and Breast Cancer

SOX2 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which play a vital role in embryonic development. SOX2 antibody research has identified Sox2 as a key transcription factor in pluripotent stem cells. We at Novus Biologicals offer a number of top quality SOX2 products in our stem cell antibody catalog.

The Sox2 Antibody Aids Brain Cancer Research

The Sox2 antibody is widely used in sensory, neuroscience and stem cell marker research. Recently, Sox2 antibody preparations identified the Sox2 protein as a marker for malignant neural gliomas. We at Novus Biologicals offer a wide variety of highly validated Sox2 antibodies.

Fluorescence Activated Cell Sorting Antibody Techniques

Recently, we at Novus Biologicals added several embryonic stem cell marker products to our antibody catalog, validated for use in fluorescent activated cell sorting (FACS) assays. They included Cripto1, PODXL, SSEA, OCT4, Nanog, SOX2, TRA-1, TERT and GPR49/LGR5 antibodies.