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T Cells

Is Monkeypox Still A Threat?

Monkeypox Graphic Banner.

By Jamshed Arslan, Pharm D, PhD

 

Tags: 
CD4
CD8
COVID-19
Immunization
immunology
Infection
Monkeypox
Orthopoxvirus
SARS-CoV-2
Smallpox
T Cells
Vaccine
virus
Jamshed Arslan

Hypoxia-Dependent CAR Stabilizing Construct in T cells Improves Solid Tumor Targeting and Efficacy

Banner image showing a chimeric antigen receptor (CAR) T cell.

By Victoria Osinski, PhD

Tags: 
Cancer
Chimeric Antigen Receptor
CAR-T
Hypoxia
immunology
Immunotherapy
Oxygen
T Cells
Tumor
Tumor Microenvironment
EGFR
ErbB2/Her2
ErbB3/Her3
ErbB4/Her4
HIF-1 alpha
Victoria Osinski

Tired T cells: Hypoxia Drives T cell Exhaustion in the Tumor Microenvironment

Banner image showing cancer cells in hypoxic conditions.

By Hunter Martinez

Tags: 
Adaptive Immunity
Hypoxia
immunology
metabolism
Mitochondria
Oxygen
ROS
T Cells
T cell exhaustion
T cell receptor
Tumor Microenvironment
BLIMP1/PRDM1
CD8
HIF-1 alpha
IFN-gamma
LAG-3
NFAT
NGFI-B alpha/Nur77/NR4A1
PD-1
PGC1 alpha
TIGIT
TNF-alpha
Hunter Martinez

Synthetic Biotic Medicine as Immunotherapy Against Cancer: Evidence From Arginine-Producing Engineered Bacteria

3D banner image showing example of pathogenic bacteria.

By Jamshed Arslan, Pharm D, PhD

Tags: 
Bacteria
Cancer
Cancer Research
Checkpoint Blockade
Checkpoint Inhibitors
immunology
Immuno-oncology
Immunotherapy
Innate Immunity
L-arginine
T Cells
Tumor
ARG-2
CD4
CD8
PD-1
PD-L1
Jamshed Arslan

Immune Cell Metabolic Flux Influences Type I Diabetes

Banner image showing mitochondrion and metabolic pathways and targets, from Tocris.

By Hunter Martinez

Tags: 
Adaptive Immunity
Diabetes
Type I Diabetes
Immunometabolism
Innate Immunity
Macrophage
metabolism
Mitochondria
mTOR Pathway
T Cells
ACSL1
CD4
COX-2
IL-1 beta/IL-1F2
IL-12
IL-18/IL-1F4
Insulin
MHC class II
PGE2
TNF-alpha
Hunter Martinez

Early T cell response is associated with mild COVID-19 and rapid SARS-CoV-2 clearance

3D rendering of T cells as a banner image.

Jamshed Arslan, Pharm D, PhD

Tags: 
Adaptive Immunity
immunology
Innate Immunity
T Cells
virology-bacteria-parasite
virus
coronavirus
COVID-19
SARS-CoV-2
SARS-CoV-2 spike protein
SARS-CoV-2 Spike S1
SARS-CoV-2 Spike RBD
spike protein
SARS-CoV-2 nucleocapsid protein
nucleocapsid protein
SARS-CoV-2 membrane protein
CD4
CD8
IgG
IgM
IFN-gamma
SARS-CoV-2 ORF7a
SARS-CoV-2 ORF8
SARS-CoV-2 ORF3a
ELISpot
Flow cytometry
Jamshed Arslan

Flow Cytometry Basics for the Non-Expert

Flow cytometry dot plots, histograms, density plots

By Jody Bonnevier, PhD.

Tags: 
CD4
CD25
CD93
Flow cytometry
Fluorochrome
Lymphocytes
T Cells
Stem Cells

Chemotherapy-induced metastasis: An unexpected foe?

Mena plasma membrane, cytosol and focal adhesion expression in human cell line U-2 OS ICC

By Yoskaly Lazo-Fernandez, PhD

Tags: 
TMEM
Breast Cancer
Tie-2
VEGF
ATF3
MENA
macrophages
Metastasis
T Cells
NK cells
immunology
Cancer
Cancer Research

Advancing CAR T Therapies with CRISPR/Cas9

Expression of CD4 and CD8 in peripheral blood mononuclear cells ICC

By Victoria Osinski

Tags: 
CRISPR-Cas9
Lymphocytes
T Cells
Tumor
Cancer
Cancer Research
CAR-T
Immunotherapy
Immuno-oncology
immunology
CRISPR/Cas9

Adenosine Inhibits T cell Tumor Infiltration: KCa3.1, a New Anticancer Target

CD8 alpha antibody, ICC

By Yoskaly Lazo-Fernandez, PhD

Tags: 
Cancer
T Cells
Immunotherapy
immunology
Hypoxia
Adenosine A2a R
CD39/ENTPD1
5'-Nucleotidase/CD73