This TLR4 antibody is useful in Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin-embedded sections and Western blot. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS and 30% Glycerol
0.05% Sodium Azide
Immunogen affinity purified
Alternate Names for TLR4 Antibody
hTollhomolog of Drosophila toll
toll-like receptor 4
Toll like receptor 4 (TLR4) detects lipopolysaccharide of bacteria. This functionality is critical to activate the innate immune system response. HSP70 expression is enhanced when TLR4 expression is increased, resulting in an impact of the heat shock pathway in inflammation caused by infection. TLR4 binds to lipopolysaccharide and potentiates G-protein coupled receptor signaling, which then induces Neu1 expression. Cell surface expression of Neu1 and TLR4 on macrophages is critical in the ligand activation and inflammation mechanisms. Ultimately, TLR4 can be considered as one of the key elements responsible for inflammatory cytokine release and positive feedback in inflammation.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
The role of TLR4 in breast cancer Toll like receptors (TLRs) are highly conserved proteins that are first known for their role in pathogen recognition and immune response activation. In order to elicit the necessary immune response in reaction to a foreign pathogen, TLRs trigger cy... Read full blog post.
TLR4 - A Guardian of Innate Immunity Toll-like receptor 4 (TLR4) belongs to the family of Toll-like receptors (TLR), and plays a main role in pathogen recognition and innate immunity system activation. The TLR family members are highly conserved proteins that all contain a high degree of... Read full blog post.
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