Human CCL2/MCP-1 Quantikine ELISA Kit

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

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Catalog# & Conjugate Size Price

Human CCL2/MCP-1 Quantikine ELISA Kit Summary

Background
The Quantikine Human MCP-1 Immunoassay is a 3.5 or 4.5 hour solid phase ELISA designed to measure MCP-1 in cell culture supernates, serum, plasma, and urine. It contains E. coli-expressed recombinant human MCP-1 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate recombinant human MCP-1. Results obtained using natural human ...MCP-1 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human MCP-1.
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Specificity
Natural and recombinant human MCP-1
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
CCL2

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DCP00.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human CCL2/MCP-1 Quantikine ELISA Kit

  • C-C motif chemokine ligand 2
  • CCL2
  • GDCF-2
  • HC11
  • HSMCR30
  • MCAF
  • Mcp1
  • MCP-1
  • SCYA2
  • SMC-CF

Background

CCL2/JE/MCP-1, is a chemokine that binds the receptor CCR2 and induces the chemoattraction of mononuclear cells. It induces the activation of monocytes, NK cells, lymphocytes, and basophils. Additionally, CCL2 promotes Th2 polarization in CD4+ T cells, and CCL2-mediated recruitment of monocytes to sites of inflammation contributes to disease severity in atherosclerosis, multiple sclerosis, and allergic asthma. Endogenous proteolytic trimming of CCL2 at the N-terminus, including the N-terminal pyrrolidone carboxylic acid-modified glutamine, downregulates activity but not receptor binding.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for CCL2/JE/MCP-1 (DCP00)(228)

We have publications tested in 5 confirmed species: Human, Rat, Porcine, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Primate - Macaca mulatta (Rhesus Macaque).


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Human
(211)
Rat
(2)
Porcine
(3)
Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
(2)
Primate - Macaca mulatta (Rhesus Macaque)
(7)
All Species
Showing Publications 1 - 10 of 228. Show All 228 Publications.
Publications using DCP00 Applications Species
HS Park, AM Abd El-Aty, JH Jeong, T Lee, TW Jung Capmatinib suppresses LPS-induced interaction between HUVECs and THP-1 monocytes through suppression of inflammatory responses Biomedical journal, 2022;0(0):. 2022 [PMID: 35483573] (Human) Human
N Lin, L Chen, Y Zhang, Y Yang, L Zhang, L Chen, P Zhang, H Su, M Yin KIF4A promotes tumor progression of bladder cancer via CXCL5 dependent myeloid-derived suppressor cells recruitment Scientific Reports, 2022;12(1):6015. 2022 [PMID: 35399116] (Human) Human
M Uchida, T Suga, M Terada, T Isaka A pilot study: the relationship between salivary MCP-1 and IgA, and exercise performance in long-distance runners and sprinters Bmc Research Notes, 2022;15(1):118. 2022 [PMID: 35346356] (Human) Human
P Ngamjanyap, S Worawichaw, P Pisitkun, K Khiewngam, S Kantachuve, A Nongnuch, M Assanatham, N Sathirapon, C Kitiyakara Predicting treatment response and clinicopathological findings in lupus nephritis with urine epidermal growth factor, monocyte chemoattractant protein-1 or their ratios PLoS ONE, 2022;17(3):e0263778. 2022 [PMID: 35271583] (Human) Human
Y Du, Z Carranza, Y Luan, K Busman-Sah, S Wolf, SP Campbell, SY Kim, T Pejovic, JD Estes, M Zelinski, J Xu Evidence of cancer therapy-induced chronic inflammation in the ovary across multiple species: A potential cause of persistent tissue damage and follicle depletion Journal of reproductive immunology, 2022;150(0):103491. 2022 [PMID: 35176661] (Human) Human
AM Abu El-Asr, A Ahmad, MI Nawaz, MM Siddiquei, A De Zutter, L Vanbrabant, PW Gikandi, G Opdenakker, S Struyf Tissue Inhibitor of Metalloproteinase-3 Ameliorates Diabetes-Induced Retinal Inflammation Frontiers in Physiology, 2021;12(0):807747. 2021 [PMID: 35082694] (Human) Human
L Liu, E Bankell, C Rippe, B Morén, KG Stenkula, BO Nilsson, K Swärd Cell Type Dependent Suppression of Inflammatory Mediators by Myocardin Related Transcription Factors Frontiers in Physiology, 2021;12(0):732564. 2021 [PMID: 34671275] (Human) Human
A Kuzumi, A Yoshizaki, KM Matsuda, H Kotani, Y Norimatsu, M Fukayama, S Ebata, T Fukasawa, A Yoshizaki-, Y Asano, K Morikawa, Y Kazoe, K Mawatari, T Kitamori, S Sato Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis Nature Communications, 2021;12(1):5947. 2021 [PMID: 34642338] (Human) Human
B Sadeghi, E Roshandel, A Pirsalehi, S Kazemi, G Sankanian, M Majidi, M Salimi, N Aghdami, H Sadrosadat, S Samadi Koc, F Alaeddini, O Ringden, A Hajifathal Conquering the cytokine storm in COVID-19-induced ARDS using placenta-derived decidua stromal cells Journal of Cellular and Molecular Medicine, 2021;0(0):. 2021 [PMID: 34632708] (Human) Human
J Tuñón, A Pello, Á Aceña, S Ramos-Cill, J Martínez-M, Ó González-L, J Fuentes-An, N Tarín, C Cristóbal, LM Blanco-Col, JL Martín-Ven, A Huelmos, C Gutiérrez-, M López-Cast, J Alonso, LL Bescós, J Egido, I Mahíllo-Fe, Ó Lorenzo N-Terminal Pro-Brain Natriuretic Peptide Plasma Levels Are Associated with Intermediate-Term Follow-Up Cancer in Coronary Patients Journal of Clinical Medicine, 2021;10(18):. 2021 [PMID: 34575153] (Human) Human
Show All 228 Publications.

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Bioinformatics

Gene Symbol CCL2