Human CCL2/MCP-1 Quantikine ELISA Kit

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

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Catalog# & Conjugate Size Price

Human CCL2/MCP-1 Quantikine ELISA Kit Summary

Background
The Quantikine Human MCP-1 Immunoassay is a 3.5 or 4.5 hour solid phase ELISA designed to measure MCP-1 in cell culture supernates, serum, plasma, and urine. It contains E. coli-expressed recombinant human MCP-1 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate recombinant human MCP-1. Results obtained using natural human ...MCP-1 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human MCP-1.
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Specificity
Natural and recombinant human MCP-1
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
CCL2

Applications/Dilutions

Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DCP00.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human CCL2/MCP-1 Quantikine ELISA Kit

  • C-C motif chemokine ligand 2
  • CCL2
  • GDCF-2
  • HC11
  • HSMCR30
  • MCAF
  • Mcp1
  • MCP-1
  • SCYA2
  • SMC-CF

Background

CCL2/JE/MCP-1, is a chemokine that binds the receptor CCR2 and induces the chemoattraction of mononuclear cells. It induces the activation of monocytes, NK cells, lymphocytes, and basophils. Additionally, CCL2 promotes Th2 polarization in CD4+ T cells, and CCL2-mediated recruitment of monocytes to sites of inflammation contributes to disease severity in atherosclerosis, multiple sclerosis, and allergic asthma. Endogenous proteolytic trimming of CCL2 at the N-terminus, including the N-terminal pyrrolidone carboxylic acid-modified glutamine, downregulates activity but not receptor binding.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for CCL2/JE/MCP-1 (DCP00)(178)

We have publications tested in 5 confirmed species: Human, Rat, Porcine, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Primate - Macaca mulatta (Rhesus Macaque).


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Human
(161)
Rat
(2)
Porcine
(3)
Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
(2)
Primate - Macaca mulatta (Rhesus Macaque)
(8)
All Species
Showing Publications 1 - 10 of 178. Show All 178 Publications.
Publications using DCP00 Applications Species
IV Kravchenko, VA Furalyov, VO Popov Glycated albumin stimulates expression of inflammatory cytokines in muscle cells Cytokine, 2020;128(0):154991. 2020 [PMID: 32000013] (Human) Human
Y He, Q Yang, X Wang, A Jia, W Xie, J Zhou Inhibition of Triggering Receptor Expressed on Myeloid Cell-1 Alleviates Acute Gouty Inflammation Mediators Inflamm., 2019;2019(0):5647074. 2019 [PMID: 31885496] (Human) Human
S Del Turco, L Quattrini, R Colucci, M Gaggini, C La Motta, G Basta A 2,3-diphenylpyrido[1,2-a] pyrimidin-4-one derivative inhibits specific angiogenic factors induced by TNF-alpha Saudi Pharm J, 2019;27(8):1174-1181. 2019 [PMID: 31885477] (Human) Human
T Kishimoto, N Fujimoto, T Ebara, T Omori, T Oguri, A Niimi, T Yokoyama, M Kato, I Usami, M Nishio, K Yoshikawa, T Tokuyama, M Tamura, Y Yokoyama, K Tsuboi, Y Matsuo, J Xu, S Takahashi, M Abdelgied, WT Alexander, DB Alexander, H Tsuda Serum levels of the chemokine CCL2 are elevated in malignant pleural mesothelioma patients BMC Cancer, 2019;19(1):1204. 2019 [PMID: 31823764] (Human) Human
FG Scurt, J Menne, S Brandt, A Bernhardt, PR Mertens, H Haller, C Chatzikyrk, Systemic Inflammation Precedes Microalbuminuria in Diabetes Kidney Int Rep, 2019;4(10):1373-1386. 2019 [PMID: 31701047] (Human) Human
D Bhatia, KP Chung, K Nakahira, E Patino, MC Rice, LK Torres, T Muthukumar, AM Choi, OM Akchurin, ME Choi Mitophagy dependent macrophage reprogramming protects against kidney fibrosis JCI Insight, 2019;0(0):. 2019 [PMID: 31639106] (Human) Human
E Scoditti, S Carpi, M Massaro, M Pellegrino, B Polini, MA Carluccio, M Wabitsch, T Verri, P Nieri, R De Caterin Hydroxytyrosol Modulates Adipocyte Gene and miRNA Expression Under Inflammatory Condition Nutrients, 2019;11(10):. 2019 [PMID: 31627295] (Human) Human
WV de Oliveir, APF Silva, RC de Figueir, KB Gomes, AC Simões E S, LMS Dusse, DRA Rios Association between dyslipidemia and CCL2 in patients undergoing hemodialysis Cytokine, 2019;125(0):154858. 2019 [PMID: 31557637] (Human) Human
SJ Park, H Kim, SH Kim, EH Joe, I Jou Epigenetic downregulation of STAT6 increases HIF-1α expression via mTOR/S6K/S6, leading to enhanced hypoxic viability of glioma cells Acta Neuropathol Commun, 2019;7(1):149. 2019 [PMID: 31530290] (Human) Human
C Lailler, C Louandre, MC Morisse, T Lhossein, C Godin, M Lottin, JM Constans, B Chauffert, A Galmiche, Z Saidak ERK1/2 signalling regulates the immune microenvironment and macrophage recruitment in glioblastoma Biosci. Rep., 2019;0(0):. 2019 [PMID: 31467175] (Human) Human
Show All 178 Publications.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for CCL2/JE/MCP-1 (DCP00). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Other Available Formats

HRP DCP00
HRP DCP00
HRP DCP00

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Bioinformatics

Gene Symbol CCL2