Human CCL2/MCP-1 Quantikine ELISA Kit Summary
The Quantikine Human MCP-1 Immunoassay is a 3.5 or 4.5 hour solid phase ELISA designed to measure MCP-1
in cell culture supernates, serum, plasma, and urine. It contains E. coli-expressed recombinant human MCP-1 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate recombinant human MCP-1. Results obtained using natural human ... MCP-1 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human MCP-1.
Natural and recombinant human MCP-1
Solid Phase Sandwich ELISA
No significant interference observed with available related molecules.
Packaging, Storage & Formulations
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Human CCL2/MCP-1 Quantikine ELISA Kit
C-C motif chemokine ligand 2 CCL2 GDCF-2 HC11 HSMCR30 MCAF Mcp1 MCP-1 SCYA2 SMC-CF Background
CCL2/JE/MCP-1, is a chemokine that binds the receptor CCR2 and induces the chemoattraction of mononuclear cells. It induces the activation of monocytes, NK cells, lymphocytes, and basophils. Additionally, CCL2 promotes Th2 polarization in CD4+ T cells, and CCL2-mediated recruitment of monocytes to sites of inflammation contributes to disease severity in atherosclerosis, multiple sclerosis, and allergic asthma. Endogenous proteolytic trimming of CCL2 at the N-terminus, including the N-terminal pyrrolidone carboxylic acid-modified glutamine, downregulates activity but not receptor binding.
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Applications: CyTOF-ready, ELISA(Cap), ELISA(Det), ELISA(Sta), ICC, ICFlow, Neut, Simple Western, WB
Applications: CyTOF-ready, Flow, IHC
Species: Hu, Rb, Rt
Applications: Flow, IHC, IHC-P, KO, WB
Applications: CyTOF-ready, Flow, IHC, WB
Applications: ICC/IF, IHC, IHC-P, WB
Species: Ca, Hu, Pm, Mu, Rt
Applications: IHC, IHC-P, IP, WB
Species: Bv, Hu, Mu
Applications: CyTOF-ready, ICC, IHC, ICFlow
⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.
Publications for CCL2/JE/MCP-1 (DCP00)(245)
We have publications tested in 7 confirmed species: Human, Mouse, Rat, Porcine, Primate - Chlorocebus aethiops (African Green Monkey), Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Primate - Macaca mulatta (Rhesus Macaque).
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Publications using DCP00
Kim, MJ;Kim, JY;Shin, JH;Kang, Y;Lee, JS;Son, J;Jeong, SK;Kim, D;Kim, DH;Chun, E;Lee, KY; FFAR2 antagonizes TLR2- and TLR3-induced lung cancer progression via the inhibition of AMPK-TAK1 signaling axis for the activation of NF-?B Cell & bioscience 2023-06-07 [PMID: 37287005] (Human)
F Bruschi, B Pinto, P Fallahi, SM Ferrari, A Antonelli Increased neutrophil derived chemokines (CXCL10 and CCL2) in human trichinellosis as possible serological markers of the polarization of the immune response against the parasite Cytokine, 2023-04-12;166(0):156205. 2023-04-12 [PMID: 37058963] (Human)
Chow, FC;Mundada, NS;Abohashem, S;La Joie, R;Iaccarino, L;Arechiga, VM;Swaminathan, S;Rabinovici, GD;Epel, ES;Tawakol, A;Hsue, PY; Psychological stress is associated with arterial inflammation in people living with treated HIV infection Brain, behavior, and immunity 2023-06-25 [PMID: 37369339] (Human)
F Parween, SP Singh, HH Zhang, N Kathuria, FA Otaizo-Car, A Shamsaddin, PJ Gardina, S Ganesan, J Kabat, HA Lorenzi, TG Myers, JM Farber Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells bioRxiv : the preprint server for biology, 2023-02-13;0(0):. 2023-02-13 [PMID: 36789428] (Human)
K Wolk, D Wilsmann-T, K Witte, TC Brembach, C Kromer, S Gerdes, K Ghoreschi, K Reich, R Mössner, R Sabat Interleukin-19 Levels Are Increased in Palmoplantar Pustulosis and Reduced following Apremilast Treatment International Journal of Molecular Sciences, 2023-01-09;24(2):. 2023-01-09 [PMID: 36674793] (Human)
G Xiromerisi, C Marogianni, IC Lampropoul, E Dardiotis, M Speletas, P Ntavarouka, A Androutsop, F Kalala, N Grigoriadi, S Papoutsopo Peripheral Inflammatory Markers TNF-alpha and CCL2 Revisited: Association with Parkinson's Disease Severity International Journal of Molecular Sciences, 2022-12-23;24(1):. 2022-12-23 [PMID: 36613708] (Human)
H Hikichi, S Seto, K Wakabayash, M Hijikata, N Keicho Transcription factor MAFB controls type I and II interferon response-mediated host immunity in Mycobacterium tuberculosis-infected macrophages Frontiers in Microbiology, 2022-11-03;13(0):962306. 2022-11-03 [PMID: 36406405] (Human)
AD Ruggiero, R Vemuri, M Block, D DeStephani, M Davis, J Chou, A Williams, A Brock, SK Das, K Kavanagh Macrophage Phenotypes and Gene Expression Patterns Are Unique in Naturally Occurring Metabolically Healthy Obesity International Journal of Molecular Sciences, 2022-10-21;23(20):. 2022-10-21 [PMID: 36293536] (Primate - Chlorocebus aethiops (African Green Monkey))
Primate - Chlorocebus aethiops (African Green Monkey)
C Ge, J Tan, X Dai, Q Kuang, S Zhong, L Lai, C Yi, Y Sun, J Luo, C Zhang, L Zhu, B Wang, M Xu Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by targeting FAK Oncogene, 2022-10-08;13(1):5945. 2022-10-08 [PMID: 36209205] (Human)
Show All 245 Publications.
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