TLR4 Products

Antibodies
TLR4 Antibody
TLR4 Antibody
NB100-56580
Species: Hu, Mu, Rt, RM
Applications: WB, ICC/IF, IHC-P
Host: Rabbit Polyclonal
Antibody Packs
ELISA Kits
Human TLR4 ELISA Kit (Colorim ...
Human TLR4 ELISA Kit (Colorimetric)
NBP2-76569
Species: Hu
Applications: ELISA
Rat TLR4 ELISA Kit (Colorimet ...
Rat TLR4 ELISA Kit (Colorimetric)
NBP2-76571
Species: Rt
Applications: ELISA
Mouse TLR4 ELISA Kit (Colorim ...
Mouse TLR4 ELISA Kit (Colorimetric)
NBP2-76570
Species: Mu
Applications: ELISA
Inhibitors
TLR4 Inhibitor Peptide Set
TLR4 Inhibitor Peptide Set
NBP2-26244
Species: Hu, Mu, Rt
Applications: Flow, Func, In vitro, B/N
Lysates
TLR4 Overexpression Lysate
TLR4 Overexpression Lysate
NBP2-05647
Species: Hu
Applications: WB
Proteins
Recombinant Human TLR4 Protei ...
Recombinant Human TLR4 Protein, CF
1478-TR
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
TLR4 Blocking Peptide
TLR4 Blocking Peptide
NBP2-24821PEP
Species: Hu
Recombinant Mouse TLR4 Fc Chi ...
Recombinant Mouse TLR4 Fc Chimera ...
9149-TR
Species: Mu
Applications: Bioactivity
Formulation Catalog # Availability Price  

Description

The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). Among this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling (4,5). The mouse TLR4 cDNA codes for a protein consisting of 835 amino acids with approximate molecular weight of 90 kDa (6).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Mouse
Product By Gene ID 7099
Alternate Names
  • ARMD10
  • CD284 antigen
  • CD284
  • hTollhomolog of Drosophila toll
  • TOLL
  • toll-like receptor 4

Research Areas for TLR4

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Cytokine Research
Immunology
Innate Immunity
Signal Transduction
Toll-Like Receptors

Bioinformatics Tool for TLR4

Discover related pathways, diseases and genes to TLR4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related TLR4 Blog Posts

Check out the latest blog posts on TLR4.
PAMPs and DAMPs: What is the same and what is different about these molecules?
By Victoria OsinskiWhat are PAMPs and DAMPsInflammation results from stimuli signaling damage or infection. The inflammatory response can be beneficial or harmful depending on the type and duration of stimuli. The s...    Read more.
How to identify B cell subsets using flow cytometry
By Victoria OsinskiUsing flow cytometry to identify B cell subsetsIdentifying cellular subsets by flow cytometry requires careful and thorough planning in order to ensure the correct subset of cells are identified a...    Read more.
Lipopolysaccharide from gut microbiome localizes in human atherosclerotic plaques and promotes TLR4-mediated oxidative stress
By Jamshed Arslan, Pharm. D., PhD. Atherosclerosis is a chronic inflammatory condition in which plaques of fats and other substances slowly buildup on the inner walls of arteries to restrict blood flow. In atheroscle...    Read more.
Toll-like receptors in the intestinal epithelial cells
By Jamshed Arslan, Pharm. D., PhD. Toll-like receptors (TLRs) are microbe-sensing proteins that act as first responders to danger signals. TLRs help the intestinal epithelial cells (IECs) recognize commensal bacteria...    Read more.
The role of STING/TMEM173 in gamma and encephalitis Herpes Simplex Virus (HSV)
Stimulator of interferon genes (STING), also known as TMEM173, promotes the production of the interferon’s IFN-alpha and IFN-beta.  STING possesses three functional domains: a cytoplasmic C-terminal tail, a central globular domain, and four N-...    Read more.
TRIF/TICAM1 and mitochondrial dynamics in the innate immune response
TRIF, also known as toll like receptor adaptor molecule 1 or TICAM1, is known for its role in invading foreign pathogens as part of our innate immune response. TRIF/TICAM1 is a TIR-domain adaptor protein (toll/interleukin-1 receptor) that interacts...    Read more.
The role of TLR4 in breast cancer
Toll like receptors (TLRs) are highly conserved proteins that are first known for their role in pathogen recognition and immune response activation.  In order to elicit the necessary immune response in reaction to a foreign pathogen, TLRs trigger cy...    Read more.
cIAP2 - balancing cell death and cell survival
The inhibitor of apoptosis proteins (IAPs) are important regulators of cell death and inflammation. The cellular inhibitor of apoptosis protein 2 (cIAP2) contains three Baculovirus IAP repeat (BIR) domains, a Ubiquitin associated (UBA) domain, and...    Read more.
TLR4 - A Guardian of Innate Immunity
Toll-like receptor 4 (TLR4) belongs to the family of Toll-like receptors (TLR), and plays a main role in pathogen recognition and innate immunity system activation. The TLR family members are highly conserved proteins that all contain a high degree of...    Read more.
IRAK4: The "master IRAK" critical for initiating immune responses
IRAK4, also known as Interleukin-1 receptor-associated kinase 4, is a serine/threonine-protein kinase that plays a critical role in initiating innate and adaptive immune responses against foreign pathogens. It activates NF-kappaB in both Toll-like rec...    Read more.
TLR4: Playing Roles in Apoptosis and Autoimmunity
TLR4 (Toll-like receptor 4) is a member of the Toll-like receptor (TLR) family that plays a key role in pathogen recognition and activation of innate immunity. Scientists have found that TLRs are highly conserved from Drosophila to humans, with a high...    Read more.
Read more TLR4 related blogs.