Reactivity | Hu, Mu, Rt, Rt, Po, Bt, Bv, Fi, Xp, ZeSpecies Glossary |
Applications | Flow, KO |
Clone | 1251A |
Clonality | Monoclonal |
Host | Rabbit |
Conjugate | PE |
Additional Information | Recombinant Monoclonal Antibody |
Immunogen | A synthetic peptide made to an N-terminal portion of the human LC3 protein sequence (between residues 1-100). [UniProt# Q9GZQ8]. |
Localization | LC3-I is cytoplasmic. LC3-II binds to the autophagic membranes. |
Marker | Autophagosomes |
Specificity | Specific for LC3B. |
Predicted Species | Rat (94%), Porcine (100%), Bovine (100%), Zebrafish (100%), Fish (100%), Bat (100%), Xenopus (94%). Backed by our 100% Guarantee. |
Isotype | IgG |
Clonality | Monoclonal |
Host | Rabbit |
Gene | MAP1LC3B |
Purity | Protein G purified |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Storage | Store at 4C in the dark. |
Buffer | PBS |
Preservative | 0.05% Sodium Azide |
Purity | Protein G purified |
Secondary Antibodies |
Isotype Controls |
Alexa Fluor 405 Labeled | NBP2-46892AF405 | |
Alexa Fluor 488 Labeled | NBP2-46892AF488 | |
Alexa Fluor 647 Labeled | NBP2-46892AF647 | |
Alexa Fluor 700 Labeled | NBP2-46892AF700 | |
Allophycocyanin Labeled | NBP2-46892APC | |
Biotin Labeled | NBP2-46892B | |
DyLight 350 Labeled | NBP2-46892UV | |
DyLight 405 Labeled | NBP2-46892V | |
DyLight 488 Labeled | NBP2-46892G | |
DyLight 550 Labeled | NBP2-46892R | |
DyLight 650 Labeled | NBP2-46892C | |
DyLight 680 Labeled | NBP2-46892FR | |
DyLight 755 Labeled | NBP2-46892IR | |
HRP Labeled | NBP2-46892H | |
PerCP Labeled | NBP2-46892PCP |
Diseases for LC3B Antibody (NBP2-46892PE)Discover more about diseases related to LC3B Antibody (NBP2-46892PE).
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PTMs for LC3B Antibody (NBP2-46892PE)Learn more about PTMs related to LC3B Antibody (NBP2-46892PE).
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Autophagy inhibition in pediatrics: One physician-scientist’s brave decision By Christina Towers, PhD. The current time from when a discovery is first made on the bench to when that discovery might translate into an approved therapy in cancer patients is an astounding 10-15 years. Scientists... Read full blog post. |
Cleaner gone bad: Autophagy regulates motor neuron loss in spinal muscular atrophy By Jamshed Arslan Pharm.D. Neuromuscular disorders affect the peripheral nervous system and muscles. Spinal muscular atrophy (SMA) is one such incurable disease in which muscles fail to receive signals from the spi... Read full blog post. |
Brain size matters: MTOR regulates autophagy and number of cortical interneurons By Jamshed Arslan Pharm.D. Interneurons transmit impulses between other neurons, in part, to facilitate the birth of neurons. Cortical interneurons themselves arise from the progenitors in the ventral telencephalon,... Read full blog post. |
Why LC3B Antibodies Make Ideal Autophagosomes Membrane Markers The human form of microtubule-associated protein light chain 3 (LC3) is expressed as 3 splice variants; LC3A, LC3B and LC3C (He et al., 2003). LC3B is a subunit of the MAP1A and MAP1B microtubule-binding pr... Read full blog post. |
LC3B: From Autophagy to Cancer LC3B is subunit component of the LC3 autophagy biomarker associated with microtubule-associated proteins MAP1A and MAP1B and one of the best characterized markers to date. In resting state it is cytosolic, but upon activation, is lapidated and becomes... Read full blog post. |
LC3B Empowers Protein Quality Control by Autophagy LC3B also known as microtubule-associated protein 1 light chain 3 beta (MAP1LC3B) is an autophagy gene that contributes appreciably to protein degradation. Autophagy is a highly synchronized and a dynamic catabolic degradation activity that plays an e... Read full blog post. |
Analyzing LC3 in Western blot Microtubule-associated protein light chain 3 (LC3) is considered one of the definitive markers of autophagy, and its use is widespread in labs throughout the world. Despite its popularity, there are several considerations when employing LC3 antibodies... Read full blog post. |
Marking the Autophagosome: the LC3 Antibody MAP1LC3 (shortened to LC3 in our antibody catalog) is one of four mammalian homologues of autophagy-related protein 8 (Atg8). It has been identified as a light chain subunit of the microtubule-associated proteins MAP1A/MAP1B. A modified form of LC3, L... Read full blog post. |
Breakdown: Interpreting LC3 Antibody WB Results In rodents, MAPLC3 (Microtubule-associated protein 1 light chain 3) is expressed in the renal visceral epithelial cells, or podocytes. LC3 antibody analysis has shown the protein accumulates in its membrane-bound form of LC3II, following conversion fr... Read full blog post. |
The Role of LC3 within the Autophagic Pathway We at Novus Biologicals have a broad antibody databasecovering the area of autophagy - over 1400 reagents in total. Autophagy is bulk degradation of cytoplasmic components - literally, self-digestion of the cell. Double-membrane vesicles, called autop... Read full blog post. |
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