LC3B Antibody (1251A) [DyLight 755]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Rt, Po, Bt, Bv, Fi, Xp, ZeSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P, KO
Clone
1251A
Clonality
Monoclonal
Host
Rabbit
Conjugate
DyLight 755

LC3B Antibody (1251A) [DyLight 755] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
A synthetic peptide made to an N-terminal portion of the human LC3 protein sequence (between residues 1-100). [UniProt# Q9GZQ8].
Localization
LC3-I is cytoplasmic. LC3-II binds to the autophagic membranes.
Marker
Autophagosomes
Specificity
Specific for LC3B.
Predicted Species
Rat (94%), Porcine (100%), Bovine (100%), Zebrafish (100%), Fish (100%), Bat (100%), Xenopus (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
MAP1LC3B
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Knockout Validated

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for LC3B Antibody (1251A) [DyLight 755]

  • Apg8b
  • ATG8F
  • Autophagy-related protein LC3 B
  • Autophagy-related ubiquitin-like modifier LC3 B
  • lc3b autophagy marker
  • LC3B
  • lc3-i, ii
  • LC3II
  • MAP1 light chain 3-like protein 2
  • MAP1A/1BLC3
  • MAP1A/MAP1B LC3 B
  • MAP1LC3B
  • microtubule associated protein 3 b
  • microtubule associated protein 3 beta
  • microtubule-associated protein 1 light chain 3 betaMAP1A/MAP1B light chain 3 B
  • microtubule-associated proteins 1A/1B light chain 3
  • microtubule-associated proteins 1A/1B light chain 3B

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for LC3B Antibody (NBP2-46892IR) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NBP2-46892AF405
Alexa Fluor 488 Labeled NBP2-46892AF488
Alexa Fluor 647 Labeled NBP2-46892AF647
Alexa Fluor 700 Labeled NBP2-46892AF700
Allophycocyanin Labeled NBP2-46892APC
Biotin Labeled NBP2-46892B
DyLight 350 Labeled NBP2-46892UV
DyLight 405 Labeled NBP2-46892V
DyLight 488 Labeled NBP2-46892G
DyLight 550 Labeled NBP2-46892R
DyLight 650 Labeled NBP2-46892C
DyLight 680 Labeled NBP2-46892FR
HRP Labeled NBP2-46892H
PE Labeled NBP2-46892PE
PerCP Labeled NBP2-46892PCP

Additional Array Products

Bioinformatics Tool for LC3B Antibody (NBP2-46892IR)

Discover related pathways, diseases and genes to LC3B Antibody (NBP2-46892IR). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for LC3B Antibody (NBP2-46892IR)

Discover more about diseases related to LC3B Antibody (NBP2-46892IR).
 

Pathways for LC3B Antibody (NBP2-46892IR)

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PTMs for LC3B Antibody (NBP2-46892IR)

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Research Areas for LC3B Antibody (NBP2-46892IR)

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Blogs on LC3B. Showing 1-10 of 12 blog posts - Show all blog posts.

Epigenetic Control of Autophagy
By Christina Towers, PhD. In the last 20 years, epigenetic regulation has become front and center for almost all fields of biology and its role in diseases like cancer and neurodegeneration are being heavily studied....  Read full blog post.

Crosstalk Between Oxidative Stress and Autophagy
By Christina Towers, PhD. Role of Reactive Species in Cellular FunctionOxidative stress is a byproduct of an imbalance between oxidants and antioxidants present in the cell resulting in dysfunctional redox signali...  Read full blog post.

Autophagy inhibition in pediatrics: One physician-scientist’s brave decision
By Christina Towers, PhD. The current time from when a discovery is first made on the bench to when that discovery might translate into an approved therapy in cancer patients is an astounding 10-15 years. Scientists...  Read full blog post.

Cleaner gone bad: Autophagy regulates motor neuron loss in spinal muscular atrophy
By Jamshed Arslan Pharm.D. Neuromuscular disorders affect the peripheral nervous system and muscles. Spinal muscular atrophy (SMA) is one such incurable disease in which muscles fail to receive signals from the spi...  Read full blog post.

Brain size matters: MTOR regulates autophagy and number of cortical interneurons
By Jamshed Arslan Pharm.D. Interneurons transmit impulses between other neurons, in part, to facilitate the birth of neurons. Cortical interneurons themselves arise from the progenitors in the ventral telencephalon,...  Read full blog post.

Why LC3B Antibodies Make Ideal Autophagosomes Membrane Markers
The human form of microtubule-associated protein light chain 3 (LC3) is expressed as 3 splice variants; LC3A, LC3B and LC3C (He et al., 2003). LC3B is a subunit of the MAP1A and MAP1B microtubule-binding pr...  Read full blog post.

LC3B: From Autophagy to Cancer
LC3B is subunit component of the LC3 autophagy biomarker associated with microtubule-associated proteins MAP1A and MAP1B and one of the best characterized markers to date. In resting state it is cytosolic, but upon activation, is lapidated and becomes...  Read full blog post.

LC3B Empowers Protein Quality Control by Autophagy
LC3B also known as microtubule-associated protein 1 light chain 3 beta (MAP1LC3B) is an autophagy gene that contributes appreciably to protein degradation. Autophagy is a highly synchronized and a dynamic catabolic degradation activity that plays an e...  Read full blog post.

Analyzing LC3 in Western blot
Microtubule-associated protein light chain 3 (LC3) is considered one of the definitive markers of autophagy, and its use is widespread in labs throughout the world. Despite its popularity, there are several considerations when employing LC3 antibodies...  Read full blog post.

Marking the Autophagosome: the LC3 Antibody
MAP1LC3 (shortened to LC3 in our antibody catalog) is one of four mammalian homologues of autophagy-related protein 8 (Atg8). It has been identified as a light chain subunit of the microtubule-associated proteins MAP1A/MAP1B. A modified form of LC3, L...  Read full blog post.

Showing 1-10 of 12 blog posts - Show all blog posts.

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Bioinformatics

Gene Symbol MAP1LC3B
Entrez