Reactivity | Hu, Mu, RtSpecies Glossary |
Applications | WB, Simple Western, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, ChIP, KO |
Host | Mouse |
Immunogen | For NB100-122: Proprietary peptide derived from the mouse/human HIF-2a. For NB100-132: Human HIF-2a amino acids 535-631. |
Specificity | These antibodies are specific for HIF-2alpha. |
Host | Mouse |
Gene | EPAS1 |
Dilutions |
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Application Notes | By Western blot, these antibodies recognize a band ~118 kDa, representing HIF-2a in induced tissues and cells. The monoclonal has been used for immunohistochemistry. The polyclonal has also been used, but success has varied. Nuclear extracts should be used for Western analysis, if possible. See individual datasheets for validated applications. |
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Publications |
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Storage | Storage is content dependent. |
Images | Ratings | Applications | Species | Date | Details | ||
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reviewed by:
Blossom Damania |
WB | 05/05/2010 |
Summary
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Diseases for HIF-2 alpha/EPAS1 Antibody Pack (NB100-902HIF2)Discover more about diseases related to HIF-2 alpha/EPAS1 Antibody Pack (NB100-902HIF2).
| Pathways for HIF-2 alpha/EPAS1 Antibody Pack (NB100-902HIF2)View related products by pathway.
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Breast cancer stem cells survive chemotherapy through S100A10-ANXA2-SPT6 interaction that epigenetically promotes OCT4-mediated stemness By Jamshed Arslan, Pharm D, PhDBreast cancer is the most common cancer among women that causes the greatest number of cancer-related deaths worldwide. After radiotherapy or cytotoxic chemotherapy like paclitax... Read full blog post. |
HIF-2 alpha: HIF1A's Homologue with Similar and Divergent Functions HIF-2 alpha is a member of the heterodimeric hypoxia-inducible factors/HIFs family (HIF-1, HIF-2, and HIF-3) which contains a common beta subunit but differ in their alpha subunits. Also called as EPAS1 or Mop2, HIF-2 alpha regulates cellular adapt... Read full blog post. |
HIF-2 alpha, Tumor Suppression and Cell Survival HIF-2 alpha is one subunit within the HIF-2 nuclear protein that regulates cellular responses to hypoxia (low oxygen tension conditions). Hydroxylation post-translational modifications on particular HIF residues target them for degradation. Luo, et al... Read full blog post. |
Gene Symbol | EPAS1 |