TLR7 Antibody


Flow (Intracellular): TLR7 Antibody [NB100-56588] - Analysis using the FITC conjugate of NB100-56588. Staining of TLR7 in TLR7/HEK 293 this antibody cells using this antibody at 2 ug/10^6 cells. Green represents more
Flow Cytometry: TLR7 Antibody [NB100-56588] - Intracellular flow analysis of TLR7 in 10^6 ThP1 cells using 2 ug of NB100-56588. Shaded histogram represents cells without antibody; green represents isotype control; red more
Flow Cytometry: TLR7 Antibody [NB100-56588] - Analysis using the PE conjugate of NB100-56588. Staining of TLR7 in human PBMCs (monocytes) using 0.5 ug/10^6 cells of NBP2-24761. The shaded histogram represents cells more

Product Details

Reactivity Hu, MuSpecies Glossary
Applications Flow, Flow-IC, IHC, IHC-Fr
1 mg/ml

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Available Conjugates
Catalog# & Conjugate Size Price

TLR7 Antibody Summary

This antibody was developed against KLH-conjugated synthetic peptide corresponding to a portion of amino acids 684-701 of human TLR7 (NP_057646).
Protein G purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.05% Sodium Azide
1 mg/ml
Protein G purified


  • Flow Cytometry (Intracellular): 0.5-2 ug/ 1x10^6 cells
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:20
  • Flow (Intracellular)
Application Notes
Flow Cytometry: (Cell Surface): see Wong et al, 2007 for details Immunohistochemistry-Frozen: (1:20) (see product citation, Chen et al., 2005)
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NB100-56588 in the following applications:

Reactivity Notes

72% sequence identity with rat protein.

Alternate Names for TLR7 Antibody

  • toll-like receptor 7


The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described. Stimulation of the NFkB signaling pathway by TLR7 suggests that it plays a role in immune response.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TLR7 Antibody (NB100-56588)(12)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 5 applications: FLOW, Flow-CS, Flow-IC, IHC-Fr, IHC-P.

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Showing Publications 1 - 10 of 12. Show All 12 Publications.
Publications using NB100-56588 Applications Species
Chamberlain ND, Kim SJ, Vila OM et al. Ligation of TLR7 by rheumatoid arthritis synovial fluid single strand RNA induces transcription of TNFa in monocytes. Ann Rheum Dis. 2013 Mar [PMID:22730373]
Schwab N, Zozulya AL, Kieseier BC et al. An imbalance of two functionally and phenotypically different subsets of plasmacytoid dendritic cells characterizes the dysfunctional immune regulation in multiple sclerosis. J Immunol. 2010 May 1 [PMID:20357264] (Flow-IC) Flow-IC
Clancy RM, Alvarez D, Komissarova E et al. Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart block. J Immunol. 2010 Feb 15 [PMID:20089705] (Flow-IC, Human) Flow-IC Human
Zhou M, McFarland-Mancini MM, Funk HM et al. Toll-like receptor expression in normal ovary and ovarian tumors. Cancer Immunol Immunother. 2009 Sep [PMID:19184006] (IHC-P, Human) IHC-P Human
Mansson A, Cardell LO. Role of atopic status in Toll-like receptor (TLR)7- and TLR9-mediated activation of human eosinophils. J Leukoc Biol. 2009 Apr [PMID:19129482] (Human) Human
Vatakis Dimitrios N, Nixon Christopher C, Bristol Gregory, Zack Jerome A. Differentially stimulated CD4+ T cells display altered human immunodeficiency virus infection kinetics: implications for the efficacy of antiviral agents. J Virol. 2009 Apr [PMID:19129455] (FLOW) FLOW
van den Brand JM, Haagmans BL, Leijten L et al. Pathology of experimental SARS coronavirus infection in cats and ferrets. Vet Pathol. 2008 Jul [PMID:18587105] (Flow-IC) Flow-IC
Cohen PA, Koski GK, Czerniecki BJ et al. STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells. Blood. 2008 Sep 1 [PMID:18577706]
Wong CK, Cheung PF, Ip WK, Lam CW. Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. Am J Respir Cell Mol Biol. 2007 Jul [PMID:17332440] (Flow-CS, Flow-IC, Human) Flow-CS, Flow-IC Human
Lee J, Wu CC, Lee KJ et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006 Feb 7 [PMID:16446426] (Flow-CS, Flow-IC, IHC-P, Human) Flow-CS, Flow-IC, IHC-P Human
Show All 12 Publications.

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Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

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Blogs on TLR7.

TLR9: For Whom the Cell Tolls
The Toll-like receptor 9 (TLR9) protein, also known as CD289, belongs to the family of Toll-like receptor (TLR) proteins which play a large role in pathogen recognition and the activation of innate immunity. Scientists using TLR9 antibodies have found...  Read full blog post.

TLR7 and Immune Response Regulation
Toll-like receptor 7 (TLR7) is a protein encoded by the TLR7 gene in humans and is a member of TLR family. TLRs controls host immune response against pathogens (e.g. viruses, bacteria and fungi) through recognition of pathogen-associated molecular pat...  Read full blog post.

TLR9 Antibodies in Immunity Research
Toll-like receptor 9 (TLR9) is a member of the toll-like receptor family that plays a key role in pathogen recognition and activation of innate immunity. Scientists using TLR9 antibodies have found the protein is highly conserved from Drosophila to hu...  Read full blog post.

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Gene Symbol TLR7

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