Imidazoquinoline Resiquimod (R-848), TLR7 and TLR8 ligand

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Imidazoquinoline Resiquimod (R-848), TLR7 and TLR8 ligand [NBP2-26231] - TLR8 stimulation with R-848 measured by SEAP Expression 293T cells were transfected with pCMV/TLR8 plasmid and pNF-kB/SEAP plasmid using ...read more
Imidazoquinoline Resiquimod (R-848), TLR7 and TLR8 ligand [NBP2-26231] - R-848 specifically activated the TLR7- or TLR8-depedent NF-kB/SEAP reporter cells in a dose dependent manner.
Imidazoquinoline Resiquimod (R-848), TLR7 and TLR8 ligand [NBP2-26231] - Formula: C17H22N4O2

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Func
Concentration
Please see the protocols for proper use of this product. If no protocol is available, contact technical services for assistance.

Order Details

Imidazoquinoline Resiquimod (R-848), TLR7 and TLR8 ligand Summary

Purity
>98%, by HPLC.

Applications/Dilutions

Application Notes
Identity determined by MS, 1H-NMR and 13C-NMR. This product is useful for activation of mouse TLR7 and human TLR7 and TLR8. Stimulation of TLR8 has been achieved with 0.5-5 ug/mL. Use in functional assays reported in scientific literature (PMID 26134251).
Publications
Read Publications using
NBP2-26231 in the following applications:

  • 3 publications

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 25532693)

Packaging, Storage & Formulations

Storage
Store at -20 °C.
Buffer
DMSO.
Concentration
Please see the protocols for proper use of this product. If no protocol is available, contact technical services for assistance.
Purity
>98%, by HPLC.

Notes

Soluble in DMSO, dichloromethane, 100% or 5% methanol; poorly soluble in acetonitrile or ethyl acetate.

Alternate Names for Imidazoquinoline Resiquimod (R-848), TLR7 and TLR8 ligand

  • 4-Amino-2-(ethoxymethyl)-a,a-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol
  • Imidazoquinoline Resiquimod (R-848),TLR7 & TLR8 ligand
  • Imidazoquinoline Resiquimod R-848
  • Imidazoquinoline Resiquimod
  • R-848
  • Resiquimod
  • S 28463

Background

Imidazoquinoline Resiquimod (R-848), TLR7 and TLR8 ligand is a low molecular weight synthetic molecule of the Imidazoquinoline family. It has potent immunostimulatory activity. It stimulates antibody secretion, cytokine production, protection from apoptosis and CD80 up-regulation. R-848 has been shown to activate only TLR7 and TLR8. This activation is MyD88 dependent and leads to the induction of the transcription factor NF-kB.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Support products are guaranteed for 6 months from date of receipt.

Publications for Imidazoquinoline Resiquimod (R-848), TLR7 and TLR8 ligand (NBP2-26231)(5)

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FAQs for Imidazoquinoline Resiquimod (R-848), TLR7 and TLR8 ligand (NBP2-26231). (Showing 1 - 1 of 1 FAQs).

  1. Can you provide the HPLC conditions for determining the purity of Imidazoquinoline Resiquimod, R-848?
    • Thank you for inquiry about the Imidazoquinoline Resiquimod, R-848, Cat No NBP2-26231. Each batch of NBP2-26231 is endotoxin free and equal to or greater than 98% pure by HPLC. Identity is determined by Mass Spec, 1H and 13C NMR.

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