CD4 Antibody

Images

 
Immunohistochemistry: CD4 Antibody [NBP1-19371] - Increased CD3+ and CD4+ T-cell occurrence in the brainstem of SHR-72 transgenic rat model for tauopathies. (A-D) Immunofluorescence staining showed CD4+ T-cells in ...read more
Immunohistochemistry: CD4 Antibody [NBP1-19371] - DBZ inhibits the accumulation of CD4+ T cells and Th2 differentiation in the AAAs. (B) The representation of immunohistochemical staining for CD4+ in abdominal aorta ...read more
Western Blot: CD4 Antibody [NBP1-19371] - CD4 antibody was tested in the following cell lysates: 1) human spleen 2) human tonsil 3) human placenta 4) human kidney 5) human liver 6) mouse spleen 7) mouse placenta 8) rat ...read more
Immunocytochemistry/ Immunofluorescence: CD4 Antibody [NBP1-19371] - CD4 antibody was tested in Jurkat cells with DyLight 488 (green). Nuclei were counterstained with DAPI (blue).
Flow Cytometry: CD4 Antibody [NBP1-19371] - An intracellular stain was performed on Jurkat cells with CD4 Antibody NBP1-19371AF488 (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then ...read more
Western Blot: CD4 Antibody [NBP1-19371] - Mouse spleen, 25ug total protein. Image from verified customer review.
Immunohistochemistry-Paraffin: CD4 Antibody [NBP1-19371] - Staining of paraffin-embedded mouse brain tissue. Photo courtesy of product review by verified customer.
Immunohistochemistry-Paraffin: CD4 Antibody [NBP1-19371] - Analysis of a FFPE tissue section of mouse brain using CD4 antibody at 1:300 dilution with HRP-DAB detection and hematoxylin counterstaining. The antibody ...read more
Immunohistochemistry-Paraffin: CD4 Antibody [NBP1-19371] - Analysis of a FFPE section of mouse spleen using CD4 antibody at 1:300 dilution with HRP-DAB detection and hematoxylin counterstaining. The antibody generated a ...read more
Immunohistochemistry-Frozen: CD4 Antibody [NBP1-19371] - Staining in mouse liver tissue.
Immunohistochemistry-Paraffin: CD4 Antibody [NBP1-19371] - Alcohol-fixed paraffin-embedded rat spleen tissue. Dilution 1:150. Image from verified customer review.
Flow Cytometry: CD4 Antibody [NBP1-19371] - An intracellular stain was performed on Jurkat cells with CD4 Antibody NBP1-19371R (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then ...read more
Simple Western: CD4 Antibody [NBP1-19371] - Lane view shows a specific band for CD4 in 0.5 mg/ml of HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.

Product Details

Summary
Reactivity Hu, Mu, Rt, Ca, RbSpecies Glossary
Applications WB, Simple Western, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

CD4 Antibody Summary

Immunogen
A synthetic peptide made to an C-terminal region of the human CD4 protein (within residues 400-458). [Swiss-Prot P01730]
Localization
Membrane
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CD4
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/ml
  • Simple Western 1:100
  • Flow Cytometry 5 ug/ml
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:50-1:500
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin 1:50-1:500
Application Notes
This CD4 antibody is useful for ICC, Western Blot, and IHC-paraffin embedded sections. In WB, a band is seen ~45 kDa. In ICC/IF, membrane staining was observed in human brain cells. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended. In ICC/IF, membrane staining was observed in Jurkat cells.

In Simple Western only 10 - 15 uL of the recommended dilution is used per data point. Separated by Size-Wes, Sally Sue/Peggy Sue.
Control
Mouse Kidney Whole Tissue Lysate (Adult Whole Normal)
Reviewed Applications
Read 9 Reviews rated 4.1
using
NBP1-19371 in the following applications:

Publications
Read Publications using
NBP1-19371 in the following applications:

Reactivity Notes

Rabbit reactivity reported in the scientific literature (PMID: 22127304). Customer feedback positive on canine.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CD4 Antibody

  • CD_antigen: CD4
  • CD4 antigen (p55)
  • CD4 antigen
  • CD4 molecule
  • CD4 receptor
  • CD4
  • CD4mut
  • T-cell surface antigen T4/Leu-3
  • T-cell surface glycoprotein CD4

Background

CD4 (cluster of differentiation 4), also known as L3T4 or T4, is a 55 kDa single chain type I transmembrane glycoprotein belonging to the immunoglobin (Ig) superfamily. CD4 is predominantly expressed on most thymocytes, a subset of mature T lymphocytes, and weakly on monocytes, tissue macrophages, dendritic cells, and granulocytes. It is also expressed on neurons and glial cells in the brain (1). CD4 is expressed along with CD8 on double positive T cells during their development in the thymus. Either CD4 or CD8 expression is then lost giving rise to single positive (SP) CD4+ or CD8+ mature T cells. CD4+ SP cells (T helper cells) further differentiate into multiple subsets of CD4+ cells including Th1, Th2, Th17, Tfh, and Treg cells which regulate humoral and cellular immunity (2). The extracellular region of CD4 consists of 372 amino acids (aa) with four immunoglobin-like domains (D1-D4). The structures of D1 and D3 resemble variable (IgV) domains while D2 and D4 resemble constant (IgC) domains (3).

Given its critical role in T cell development, CD4 also has diverse immunology-related functions. CD4 acts as a coreceptor with the T-cell receptor (TCR) during T cell activation and thymic differentiation by binding directly to major histocompatibility complex (MHC) class II antigens and associating with the protein tyrosine kinase, Lck (4). This interaction contributes to the formation of the immunological synapse (5). Defects in antigen presentation cause dysfunction of CD4+ T cells and the almost complete loss of MHC II expression on B cells in peripheral blood, as observed in severe combined immunodeficiency (SCID) (6). CD4 also functions as a receptor for the human immunodeficiency virus (HIV) by binding to gp120, the envelope glycoprotein of HIV-1. It has been shown that the V-like domains are critical for binding to gp120 (7). In immune mediated and infectious diseases of the central nervous system, CD4 functions as an indirect mediator of neuronal damage (8).

References

1. Omri, B., Crisanti, P., Alliot, F., Marty, M., Rutin, J., Levallois, C.,... Pessac, B. (1994). CD4 expression in neurons of the central nervous system. International Immunology, 6(3), 377-385. doi:10.1093/intimm/6.3.377

2. Wan, Y. Y., & Flavell, R. A. (2009). How diverse-CD4 effector T cells and their functions. Journal of Molecular Cell Biology, 1(1), 20-36. doi:10.1093/jmcb/mjp001

3. Wu, H., Myszka, D. G., Tendian, S. W., Brouillette, C. G., Sweet, R. W., Chaiken, I. M., & Hendrickson, W. A. (1996). Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding. Proceedings of the National Academy of Sciences, 93(26), 15030-15035. doi:10.1073/pnas.93.26.15030

4. Doyle, C., & Strominger, J. L. (1987). Interaction between CD4 and class II MHC molecules mediates cell adhesion. Nature, 330, 256-259. doi:10.1038/330256a0

5. Vignali, D. A. (2010). CD4 on the road to coreceptor status. The Journal of Immunology, 184(11), 5933-5934. doi:10.4049/jimmunol.1090037

6. Tasher, D., & Dalal, I. (2012). The genetic basis of severe combined immunodeficiency and its variants. The Application of Clinical Genetics, 5, 67-80. doi:10.2147/tacg.s18693

7. Arthos, J., Deen, K. C., Chaikin, M. A., Fornwald, J. A., Sathe, G., Sattentau, Q. J.,... Sweet, R. W. (1989). Identification of the residues in human CD4 critical for the binding of HIV. Cell, 57(3), 469-481. doi:10.1016/0092-8674(89)90922-7

8. Buttini, M., Westland, C. E., Masliah, E., Yafeh, A. M., Wyss-Coray, T., Mucke, L. (1998). Novel role of human cd4 molecule identified in neurodegeneration. Nature Medicine, 4(4), 441-446. doi:10.1038/nm0498-441

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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NBP1-19371
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Applications: WB, Simple Western, Flow, ICC/IF, IHC, IHC-Fr, IHC-P

Publications for CD4 Antibody (NBP1-19371)(29)

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Canine, Rabbit.

We have publications tested in 5 applications: ICC/IF, IHC, IHC-Fr, IHC-P, WB.


Filter By Application
ICC/IF
(7)
IHC
(11)
IHC-Fr
(2)
IHC-P
(6)
WB
(2)
All Applications
Filter By Species
Human
(3)
Mouse
(18)
Rat
(4)
Canine
(1)
Rabbit
(2)
All Species
Showing Publications 1 - 10 of 29. Show All 29 Publications.
Publications using NBP1-19371 Applications Species
Herath KHINM, Kim HJ, Kim A et al. The Role of Fucoidans Isolated from the Sporophylls of Undaria pinnatifida against Particulate-Matter-Induced Allergic Airway Inflammation: Evidence of the Attenuation of Oxidative Stress and Inflammatory Responses Molecules Jun 22 2020 [PMID: 32580518] (IHC-P, Mouse) IHC-P Mouse
Zhang C, Frye M, Sun W et al. New insights on repeated acoustic injury: Augmentation of cochlear susceptibility and inflammatory reaction resultant of prior acoustic injury Hearing Research Jan 1 2020 [PMID: 32534268] (IHC, Mouse) IHC Mouse
Song KH, Jung SY, Park JI et al. Evaluation of Anti-Tumor Effects of Whole-Body Low-Dose Irradiation in Metastatic Mouse Models Cancers (Basel) Apr 30 2020 [PMID: 32365904] (ICC/IF, Mouse) ICC/IF Mouse
Partridge BR, O'Brien TJ, Lorenzo MF et al. High-Frequency Irreversible Electroporation for Treatment of Primary Liver Cancer: A Proof-of-Principle Study in Canine Hepatocellular Carcinoma J Vasc Interv Radiol Jan 16 2020 [PMID: 31956003] (Canine) Canine
Wang W, Cohen JA, Wallrapp A et al. Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung Immunity Nov 18 2019 [PMID: 31757673] (Mouse) Mouse
Bishehsari F, Engen P A et al. Abnormal Eating Patterns Cause Circadian Disruption and Promote Alcohol-Associated Colon Carcinogenesis. Cell Mol Gastroenterol Hepatol Feb 11 2019 [PMID: 31689559] (IHC, Mouse) IHC Mouse
Lee MS, Lin HS, Wallace CG, Sheu JJ. Impact of Combined Adipose-Derived Mesenchymal Stem Cell (ADMSC) and Low-Energy of Extracorporeal Shock Wave Therapy on Protecting Brain Death-Induced Remote Organ Damage in Rat Neuropsychiatry (IHC, ICC/IF, Rat) IHC, ICC/IF Rat
Hong SK, Choo EH, Ihm SH, Chang KY High fat diet downregulates regulatory T cells in the myocardium of spontaneous hypertensive rats Nutr Metab Cardiovasc Dis 2019 Nov 01 [PMID: 31585776] (IHC-Fr, Rat) IHC-Fr Rat
Wu Y, Qin YH, Liu Y et al. Cardiac troponin I autoantibody induces myocardial dysfunction by PTEN signaling activation EBioMedicine Aug 29 2019 [PMID: 31474552] (IHC-P, Human, Mouse) IHC-P Human, Mouse
Jung KJ, Lee GW, Park CH et al. Mesenchymal Stem Cells Decrease Oxidative Stress in the Bowels of Interleukin-10 Knockout Mice Gut Liver Jan 15 2020 [PMID: 31158947] (WB, Mouse) WB Mouse
Show All 29 Publications.

Reviews for CD4 Antibody (NBP1-19371) (9) 4.19

Average Rating: 4.1
(Based on 9 reviews)
We have 9 reviews tested in 4 species: Human, Mouse, Other, Sprague-Dawley rat.

Reviews using NBP1-19371:
Filter by Applications
IHC-P
(4)
IHC-Fr
(2)
WB
(2)
Flow
(1)
All Applications
Filter by Species
Human
(1)
Mouse
(4)
Other
(1)
Sprague-Dawley rat
(1)
All Species
Images Ratings Applications Species Date Details
Immunohistochemistry-Paraffin CD4 NBP1-19371
Enlarge
5
reviewed by:
Anonymous
IHC-P Sprague-Dawley rat 01/04/2019
View

Summary

ApplicationImmunohistochemistry-Paraffin
Sample TestedSpleen tissue
SpeciesSprague-Dawley rat
LotG1

Comments

CommentsAlcohol-fixed paraffin-embedded rat spleen tissue. Dilution: 1:150
Immunohistochemistry-Frozen CD4 NBP1-19371
Enlarge
4
reviewed by:
Anonymous
IHC-Fr Mouse 06/05/2018
View

Summary

ApplicationImmunohistochemistry-Frozen
Sample TestedLiver
SpeciesMouse
LotNBP1-19371SS
Immunohistochemistry-Frozen CD4 NBP1-19371
Enlarge
4
reviewed by:
Manuel Flores
IHC-Fr Mouse 03/16/2017
View

Summary

ApplicationImmunohistochemistry-Frozen
Sample TestedMouse Spleen
SpeciesMouse
Immunohistochemistry-Paraffin CD4 NBP1-19371
Enlarge
3
reviewed by:
Anonymous
IHC-P Mouse 10/06/2015
View

Summary

ApplicationImmunohistochemistry-Paraffin
Sample TestedMouse Spleen
SpeciesMouse
LotB-3
Immunohistochemistry-Paraffin CD4 NBP1-19371
Enlarge
4
reviewed by:
Merissa Olmer
IHC-P 10/04/2014
View

Summary

ApplicationImmunohistochemistry-Paraffin
LotA-2
CommentsThese tissue samples were fixed with zinc buffered formalin.
Western Blot CD4 NBP1-19371
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4
reviewed by:
Anonymous
WB Other 09/19/2014
View

Summary

ApplicationWestern Blot
Sample TestedDog Spleen Homogenate
SpeciesOther
CommentsMembrane was dual stained with primary antibodies to CD4 (detailed here) and CD8 alpha chain (also raised in rabbit, not detailed here). I included a long term exposure time to show non-specific bands. Bands of interest are present at ~54 kDa (CD4) and ~26kDa (CD8 alpha chain).

Blocking

Blocking DetailsTBS, 0.1% Tween, 5% Milk; 1 hour at 4C

Primary Anitbody

Dilution Ratio0.1ug/ul in TBS, 0.1% Tween, 5% Milk; 15 hours at 4C

Secondary Antibody

Secondary Descriptiondonkey anti-rabbit IgG-HRP
Secondary Manufacturer Cat#sc-2077
Secondary Concentration1:5000

Details

Detection NotesECL; exposed for 5min and 15 hours

Comments

CommentsMembrane was dual stained with primary antibodies to CD4 (detailed here) and CD8 alpha chain (also raised in rabbit, not detailed here). I included a long term exposure time to show non-specific bands. Bands of interest are present at ~54 kDa (CD4) and ~26kDa (CD8 alpha chain).
Western Blot CD4 NBP1-19371
Enlarge
5
reviewed by:
Anonymous
WB 08/28/2014
View

Summary

ApplicationWestern Blot
CommentsThis was my first time using this antibody - nothing like it working right off the bat! However, I used 0.5ug/mL primary with 25ug spleen protein, and only had to expose my film for 30 seconds. I'm going to try 0.1, possibly 0.01 ug/mL next time.
  4
reviewed by:
Rahul Mittal
Flow Human 04/24/2010
View

Summary

ApplicationFlow Cytometry
Sample TestedHuman peripheral blood cells
SpeciesHuman
Lot360985
Immunohistochemistry-Paraffin CD4 NBP1-19371
Enlarge
4
reviewed by:
Rahul Mittal
IHC-P Mouse 04/22/2010
View

Summary

ApplicationImmunohistochemistry-Paraffin
Sample TestedMouse Brain Tissue
SpeciesMouse
Lot360985

Details

Detection NotesAntigen Retrieval: High Ph Antigen retrieval solution, 20 minutes at 95 degrees Celsius
Fixation DetailsSample Preparation: Paraffin embedded

Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for CD4 Antibody (NBP1-19371). (Showing 1 - 4 of 4 FAQs).

  1. I want to stain some T cell subsets (Th17 and Th1), do you have antibodies for that? I need for flow cytometer in sheep or goat.
    • Unfortunately, we have neither a CD4 antibody nor an IL-17 antibody that has been validated in sheep or goat, although if you would like to try one you would again be eligible for our Innovators Reward Program. Please contact us at innovators@novusbio.com with any questions regarding this program.
  2. Unmasking method used for detection of Mouse CD4 cells in FFPE tissue secitons with NBP1-19371. HIER with citrate buffer pH6 or enzyme digestion. Details would be very much appreciated. I have this Ab and need some information before I begin to use it on mouse FFPE tissues.
    • I would recommend antigen retrieval using citrate buffer at pH6. Please see this link for our antigen retrieval protocol.
  3. Has this antibody ever been tested on fixed tissue without using antigen retrieval?
    • I just had a look at our QC records and I do not see any mention on using this antibody without antigen retrieval. Moreover, the inclusion or exclusion of antigen retrieval step in protocol depends primarily on the time allowed for tissues fixation (if the tissues were left in fixative for longer time, say more than 14 hours, I would not suggest you to omit the antigen retrieval step). The IHC use of our above mentioned antibody has been cited in couple of recent peer reviewed publications (Immunol Lett. 2011 Aug 30;138:169-78; Cryobiology. 2012 Feb;64:27-32) and you may follow the same for comparison of your IHC outcome.
  4. What isoform of IgG is the following antibody: NBP1-19371AF405?
    • We have only designated that it is IgG and have not isotyped it further.

Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP1-19371AF350
Alexa Fluor 405 NBP1-19371AF405
Alexa Fluor 488 NBP1-19371AF488
Alexa Fluor 532 NBP1-19371AF532
Alexa Fluor 594 NBP1-19371AF594
Alexa Fluor 647 NBP1-19371AF647
Alexa Fluor 700 NBP1-19371AF700
Alexa Fluor 750 NBP1-19371AF750
Biotin NBP1-19371B
DyLight 350 NBP1-19371UV
DyLight 405 NBP1-19371V
DyLight 488 NBP1-19371G
DyLight 550 NBP1-19371R
DyLight 594 NBP1-19371DL594
DyLight 650 NBP1-19371C
DyLight 680 NBP1-19371FR
DyLight 755 NBP1-19371IR
FITC NBP1-19371F
HRP NBP1-19371H
Janelia Fluor 549 NBP1-19371JF549
Janelia Fluor 646 NBP1-19371JF646

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Blogs on CD4. Showing 1-10 of 17 blog posts - Show all blog posts.

Success of combined IL-10 and IL-12 therapy in colon cancer depends on IFN-gamma and gut barrier integrity
By Jamshed Arslan, Pharm. D., PhD. Colon cancer is responsible for over 600,000 deaths per year worldwide. Colon cancer can be classified into two categories: mismatch repair (MMR)-deficient and MMR-proficient cancers...  Read full blog post.

mTOR Signaling and the Tumor Microenvironment
By Yoskaly Lazo-Fernandez, PhD The mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase that, as a member of two distinct intracellular protein complexes, mTORC1 and mTORC2, regulates protein...  Read full blog post.

Flow Cytometry Basics for the Non-Expert
By Jody Bonnevier, PhD.Flow cytometry: A Challenging Interdisciplinary ApplicationFlow cytometry has long been the cell analysis method of choice for immunologists, however more and more disciplines have recognize...  Read full blog post.

The role of MHC Class II RT1B and immune response post brain injury
The major histocompatibility complex (MHC) is responsible for binding peptide fragments arising from pathogens in order to display them on the cell surface for recognition from immune cells.  Once recognized, the foreign pathogen is typically evade...  Read full blog post.

Topics in CD11b: The innate immune response
Integrins are transmembrane receptors composed of alpha and beta chains, where beta-integrins are mainly expressed in leukocytes. Leukocytes are white blood cells that act in the immune system to defend our body against foreign pathogens.  Integrin...  Read full blog post.

Transferrin and the blood brain barrier
Transferrin, an iron binding protein that facilitates iron uptake in cells, is an integral part of a mechanism that may introduce antibody therapies to the central nervous system. Currently, the brain’s ability to take in antibody therapies i...  Read full blog post.

MHC Class I and the Herpes Simplex Virus
MHC molecules (also known as major histocompatibility complex molecules) assist in the presentation of antigens to T cells in order to eradicate foreign pathogens.  These molecules are highly polymorphic, meaning that they exist in multiple varian...  Read full blog post.

CD3 (OKT3) as a marker of immune response efficiency
Our immune system is a powerful defense mechanism against infection, however different variables can cause our immune response to work for or against us.  CD3 (cluster of differentiation 3) is one component of our immune signal response that is co...  Read full blog post.

CD20 (Cluster of differentiation 20, Membrane-spanning 4-domains subfamily A member 1 (MS4A1), CVID5, B-lymphocyte surface antigen B1)
CD20 is a human B-lymphocyte surface molecule that spans the membrane four times and is expressed on both normal and malignant cells. The CD20 antigen displays a unique expression pattern among hematopoietic cells - it is present on human pre B-ly...  Read full blog post.

CD8 alpha - Marker for cytotoxic T lymphocytes
The T-cell co-receptor CD8 is a cell-surface glycoprotein that bridges the lipid bilayer by interacting externally with ligands, such as major histocompatibility complex (MHC) class I, as well as internally with signaling molecules such as tyrosine ki...  Read full blog post.

Showing 1-10 of 17 blog posts - Show all blog posts.
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Recent Reviews

4.1
5
2
4
6
3
1
2
0
1
0

Anonymous
01/04/2019
Application: IHC-P
Species: Sprague-Dawley rat

Anonymous
06/05/2018
Application: IHC-Fr
Species: Mouse

Manuel Flores
03/16/2017
Application: IHC-Fr
Species: Mouse

Bioinformatics

Gene Symbol CD4
Entrez
Uniprot