TLR4 Antibody (76B357.1)


Orthogonal Strategies: Dual RNAscope ISH-IHC: TLR4 Antibody (76B357.1) [NB100-56566] - FFPE tissue sections of human tonsil were probed for TLR4 mRNA (ACD RNAScope Probe, ACD catalog # 311281; Fast Red chromogen, more
Flow Cytometry: TLR4 Antibody (76B357.1) [NB100-56566] - Analysis using the Alexa Fluor (R) 647 conjugate of NBP2-27149. TLR4 expression on monocytes from human peripheral blood. PBMC were stained in a 2 color flow more
Immunohistochemistry: TLR4 Antibody (76B357.1) [NB100-56566] - Pericryptal Myofibroblasts are Responsible for Increased TLR4 Expression in a Subset of CRCs. Double-stained immunofluorescence for TLR4 (green) and more
Western Blot: TLR4 Antibody (76B357.1) [NB100-56566] - Analysis using 2 ug/mL on (A) human intestine and 6 ug/mL on (B) mouse intestine and (C) rat intestine lysate.
Immunohistochemistry: TLR4 Antibody (76B357.1) [NB100-56566] - Pericryptal Myofibroblasts are Responsible for Increased TLR4 Expression in a Subset of CRCs. IHC staining of colon adenocarcinoma for TLR4, vimentin, and more
Flow (Intracellular): TLR4 Antibody (76B357.1) [NB100-56566] - Analysis using PE conjugate of NBP2-27149. An intracellular stain was performed on Jurkat cells with TLR4 antibody (76B357.1) NBP2-27149PE (blue) and an more
Immunohistochemistry: TLR4 Antibody (76B357.1) [NB100-56566] - Immunofluorescent staining of TMAs. Representative tissue cores from normal (I), adenomatous polyps (II), and CRC (III and IV) are shown. Image collected more
Immunohistochemistry-Paraffin: TLR4 Antibody (76B357.1) [NB100-56566] - Analysis of rat salivary gland tissue section at 1:100 dilution. The antibody generated a membrane-cytoplasmic staining in the tissue with stronger more
Immunohistochemistry-Paraffin: TLR4 Antibody (76B357.1) [NB100-56566] - Tissue section of normal human skin stained with antibody at 5 ug/mL. Membrane-cytoplasmic immunopositivity of TLR4 was primarily observed in the more
Flow Cytometry: TLR4 Antibody (76B357.1) [NB100-56566] - Analysis of formaldehyde fixed THP-1 cells (human monocytic leukemia cells) using 2 ug/10^6 cells TLR4 antibody (clone 76B357.1) with detection employing a donkey more
Immunohistochemistry-Paraffin: TLR4 Antibody (76B357.1) [NB100-56566] - Human skin stained with at 5 ug/mL, peroxidase-conjugate and DAB chromogen. Staining of formalin-fixed tissues is enhanced by boiling tissue more
Immunohistochemistry-Paraffin: TLR4 Antibody (76B357.1) [NB100-56566] - Analysis of TLR4 in FFPE human colon tissue using an isotype control (top) and NB100-56566 (bottom) at 5 ug/mL.
Immunohistochemistry-Paraffin: TLR4 Antibody (76B357.1) [NB100-56566] - Human testis tissue stained with antibody at 5 ug/mL.
Immunohistochemistry-Frozen: TLR4 Antibody (76B357.1) [NB100-56566] - This image is TLR4(green) and nucleus(blue) at area postrema of the adult male mouse brain, x20 magnification. Primary antibody diluted 1:500. IHC-Fr more

Product Details

Reactivity Hu, Mu, Rt, Po, Bv, Ma, Pm, ChHaSpecies Glossary
Applications WB, ChIP, DB, ELISA, Flow, Flow-CS, Flow-IC, ICC/IF, IHC, IHC-Fr, IHC-P, In vitro, PAGE, B/N, CyTOF-ready, Dual ISH-IHC, ELISA(Cap), KD, KO
1.0 mg/ml
Validated by:

Orthogonal Strategies


Order Details

TLR4 Antibody (76B357.1) Summary

This TLR4 Antibody (76B357.1) was developed against a portion of amino acids 100-200 of human TLR4 (NP_612564).
Predicted Species
Baboon (100%), Chinese Hamster (100%). Backed by our 100% Guarantee.
IgG2b Kappa
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 1 - 3 ug/mL
  • Chromatin Immunoprecipitation 1:10-1:500
  • Dot Blot
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence 1:10 - 1:500
  • Immunohistochemistry 1:10 - 1:500
  • Immunohistochemistry-Frozen 1:500
  • Immunohistochemistry-Paraffin 5 ug/mL
  • In vitro assay
  • SDS-Page
  • Block/Neutralize
  • CyTOF-ready
  • Dual RNAscope ISH-IHC
  • ELISA Capture (Matched Antibody Pair) 0.5 ug
  • Flow (Cell Surface)
  • Flow (Intracellular)
  • Knockdown Validated
  • Knockout Validated
Application Notes
Use in sds Page reported in scientific literature (PMID:33166339)
Theoretical MW
95.7 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Reviewed Applications
Read 5 Reviews rated 4.2
NB100-56566 in the following applications:

Read Publications using
NB100-56566 in the following applications:

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.05% Sodium Azide
1.0 mg/ml
Protein G purified

Alternate Names for TLR4 Antibody (76B357.1)

  • 76B357.1
  • ARMD10
  • CD_antigen: CD284
  • CD284 antigen
  • CD284
  • EC
  • EC:
  • homolog of Drosophila toll
  • hToll
  • tlr4 76B357.1
  • TLR4 facs
  • TLR4 flow cytometry
  • TLR4 human
  • TLR4 ihc
  • TLR4 western blot
  • TLR4
  • TLR-4
  • toll like receptor 4 protein
  • TOLL
  • toll-like receptor 4


TLR4 (Toll-like receptor 4) is a type-1 transmembrane glycoprotein that is a pattern recognition receptor (PRR) belonging to the TLR family (1-3). TLR4 is expressed in many tissues and is most abundantly expressed in the placenta, spleen, and peripheral blood leukocytes (1). Human TLR4 is synthesized as a 839 amino acid (aa) protein containing a signal sequence (1-23 aa), an extracellular domain (ECD) (24-631 aa), a transmembrane domain (632-652 aa), and Toll/interleukin-1 receptor (TIR) cytoplasmic domain (652-839 aa) with a theoretical molecular weight of 95 kDa (3, 4). The ECD contains 21 leucine-rich repeats (LRRs) and has a horseshoe-shaped structure (3, 4). TLR4 requires binding with the co-receptor myeloid differentiation protein 2 (MD2) largely via hydrophilic interactions for proper ligand sensing and signaling (2-4). In general, the TLR family plays a role in activation of innate immunity and responds to a variety of pathogen-associated molecular patterns (PAMPs) (5). TLR4 is specifically responsive to lipopolysaccharide (LPS), which is found on the outer-membrane of most ram-negative bacteria (3-5). Activation of TLR4 requires binding of a ligand, such as LPS to MD2, followed by MD2-LPS complex binding to TLR4, resulting in a partial complex (TLR4-MD2/LPS) (3, 5). To become fully active, two partial complexes must dimerize thereby allowing the TIR domains of TLR4 to bind other adapter molecular and initiate signaling, triggering an inflammatory response and cytokine production (3, 5).

TLR4 signaling occurs through two distinct pathways: The MyD88 (myeloid differentiation primary response gene 88)-dependent pathway and the MyD88-independent (TRIF-dependent, TIR domain-containing adaptor inducing IFN-beta) pathway (3, 5-7). The MyD88-dependent pathway occurs mainly at the plasma membrane and involves the binding of MyD88-adaptor-like (MAL) protein followed by a signaling cascade that results in the activation of transcription factors including nuclear factor-kappaB (NF-kappaB) that promote the secretion of inflammatory molecules and increased phagocytosis (5-7). Conversely, the MyD88-independent pathway occurs after TLR4-MD2 complex internalization in the endosomal compartment. This pathway involves the binding of adapter proteins TRIF and TRIF-related adaptor molecule (TRAM), a signaling activation cascade resulting in IFN regulatory factor 3 (IRF3) translocation into the nucleus, and secretion of interferon-beta (INF-beta) genes and increased phagocytosis (5-7).

Given its expression on immune-related cells and its role in inflammation, TLR4 activation can contribute to various diseases (6-8). For instance, several studies have found that TLR4 activation is associated with neurodegeneration and several central nervous system (CNS) pathologies, including Alzheimer's disease, Parkinson's disease, and Huntington's disease (6, 7). Furthermore, TLR4 mutations have been shown to lead to higher rates of infections and increased susceptibility to sepsis (7-8). One potential therapeutic approach aimed at targeting TLR4 and neuroinflammation is polyphenolic compounds which include flavonoids and phenolic acids and alcohols (8).

Alternative names for TLR4 includes 76B357.1, ARMD10, CD284 antigen, CD284, EC, homolog of Drosophila toll, hToll, toll like receptor 4 protein, TOLL, toll-like receptor 4.


1. Vaure, C., & Liu, Y. (2014). A comparative review of toll-like receptor 4 expression and functionality in different animal species. Frontiers in immunology.

2. Park, B. S., & Lee, J. O. (2013). Recognition of lipopolysaccharide pattern by TLR4 complexes. Experimental & molecular medicine.

3. Krishnan, J., Anwar, M.A., & Choi, S. (2016) TLR4 (Toll-Like Receptor 4). In: Choi S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY.

4. Botos, I., Segal, D. M., & Davies, D. R. (2011). The structural biology of Toll-like receptors. Structure.

5. Lu, Y. C., Yeh, W. C., & Ohashi, P. S. (2008). LPS/TLR4 signal transduction pathway. Cytokine.

6. Leitner, G. R., Wenzel, T. J., Marshall, N., Gates, E. J., & Klegeris, A. (2019). Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders. Expert opinion on therapeutic targets.

7. Molteni, M., Gemma, S., & Rossetti, C. (2016). The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation. Mediators of inflammation.

8. Rahimifard, M., Maqbool, F., Moeini-Nodeh, S., Niaz, K., Abdollahi, M., Braidy, N., Nabavi, S. M., & Nabavi, S. F. (2017). Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation. Ageing research reviews.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Species: Hu, Mu, Rt, Po, Bv, Ma, Pm, ChHa
Applications: WB, ChIP, DB, ELISA, Flow, Flow-CS, Flow-IC, ICC/IF, IHC, IHC-Fr, IHC-P, In vitro, PAGE, B/N, CyTOF-ready, Dual ISH-IHC, ELISA(Cap), KD, KO
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Publications for TLR4 Antibody (NB100-56566)(105)

We have publications tested in 6 confirmed species: Human, Mouse, Rat, Bovine, Mammal, Porcine.

We have publications tested in 17 applications: B/N, ChIP, DB, ELISA, FLOW, Flow, Flow-CS, Flow-IC, ICC/IF, IHC, IHC-Fr, IHC-P, In-vitro, KD, Page, WB, WB,ICC/IF.

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Showing Publications 1 - 10 of 105. Show All 105 Publications.
Publications using NB100-56566 Applications Species
Liu L, Aron CZ, Grable CM, et al. Surfactant protein A reduces TLR4 and inflammatory cytokine mRNA levels in neonatal mouse ileum Scientific reports Jan 28 2021 [PMID: 33510368] (WB, Mouse, Human) WB Mouse, Human
Liu J, Li L, Luo N et al. Inflammatory signals induce MUC16 expression in ovarian cancer cells via NF‑kappa B activation Experimental and Therapeutic Medicine Dec 21 2020 [PMID: 33456530] (Human)

HEY cell lines
Bidne KL. Investigating the ovarian response to endotoxemia. Thesis Jul 9 1905 (WB, Porcine) WB Porcine
Yeh WJ, Tsai CC, Ko J, Yang HY Hylocereus polyrhizus Peel Extract Retards Alcoholic Liver Disease Progression by Modulating Oxidative Stress and Inflammatory Responses in C57BL/6 Mice Nutrients Dec 18 2020 [PMID: 33353102] (WB, Mouse) WB Mouse
Soto-Tinoco E, Santacruz E, Basualdo-Sigales MDC et al. Time-of-Day-Dependent Gating of the Liver-Spinal Axis Initiates an Anti-Inflammatory Reflex in the Rat eNeuro Dec 10 2020 [PMID: 33203733] (WB, Rat) WB Rat
Lee CY, Park HK, Lee BS et al. Novel Therapeutic Effects of Pterosin B on Ang II-Induced Cardiomyocyte Hypertrophy Molecules Nov 12 2020 [PMID: 33198253] (WB, Rat)

H9c2 cells treated with Ang II, resulting in hypertrophy, underwent Western blot analysis.
WB Rat
Holdbrooks AT, Ankenbauer KE, Hwang J, Bellis SL Regulation of inflammatory signaling by the ST6Gal-I sialyltransferase PLoS One Nov 9 2020 [PMID: 33166339] (Page) Page
Min WP, Wei XF Nervilifordin F alleviates intestinal ischemia/reperfusion-induced acute lung injury via inhibiting inflammasome and mTOR pathway Auris Nasus Larynx Oct 8 2020 [PMID: 33077306] (WB, Rat) WB Rat
Chen YL, Shirakawa H, Lu NS et al. Impacts of fish oil on the gut microbiota of rats with alcoholic liver damage J. Nutr. Biochem. Sep 10 2020 [PMID: 32920090] (WB, Rat) WB Rat
Seimetz M, Sommer N, Bednorz M et al. NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD Nat Metab Jun 1 2020 [PMID: 32694733]
Show All 105 Publications.

Reviews for TLR4 Antibody (NB100-56566) (5) 4.25

Average Rating: 4.2
(Based on 5 reviews)
We have 5 reviews tested in 2 species: Mouse, Other.

Reviews using NB100-56566:
Filter by Applications
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Images Ratings Applications Species Date Details
 TLR4 NB100-56566
reviewed by:
Mouse 05/25/2017


Sample Testedbrain tissue slice(30um


CommentsIHC-frozen, 1:500
Immunohistochemistry TLR4 NB100-56566
reviewed by:
Hayk Simonyan
IHC Mouse 05/16/2017


Sample Tested Mouse brain,Adult mouse brain tissue,Mouse cortex
Western Blot TLR4 NB100-56566
reviewed by:
Aileen Keating
WB Other 05/12/2016


ApplicationWestern Blot
Sample TestedPig whole ovarian lysate


Blocking Details5% BSA in.2% PBST for 3 hours at room temperature, rocking

Primary Anitbody

Dilution Ratio1:500 in 5% BSA.2% PBST, overnight, at 4 degrees Celsius, rocking

Secondary Antibody

Secondary DescriptionHorse anti-mouse IgG, HRP
Secondary Manufacturer Cat#Cell Signaling: 7076
Secondary Concentration1:1000 in 5% BSA.2% PBST


Detection NotesECL substrate, Alpha Innotech MultiImage Light Cabinet, 30 sec exposure. Controls negative for signal (1° only, 2° only, IgG).
Western Blot TLR4 NB100-56566
reviewed by:
Liyong Zhang
WB Mouse 08/07/2014


ApplicationWestern Blot
FileView PDF
Western Blot TLR4 NB100-56566
reviewed by:
Courtney Kurtz
WB Other 08/11/2011


ApplicationWestern Blot
Sample Testedsmall intestinal lysate, Sample Amount: 50 ug
CommentsWorks very well with chemiluminescent detection, but not quite strong enough for a good signal with colorimetric detection. Overall good! Appears slightly smaller than normal, although this can happen in my particular species. Only band observed on blot.


Blocking DetailsBlocking Buffer: 4% milk, Blocking Time: 1 hour, Blocking Temp: Room temperature

Primary Anitbody

Dilution RatioDilution Ratio: 1:250, Incubation Dilution Buffer: 4% milk, Incubation Time: overnight, Incubation Temp: 4 degrees Celsius

Secondary Antibody

Secondary DescriptionSecondary Ab: goat anti-mouse poly-HRP, Secondary Ab Dilution Ratio: 1:1500


Detection NotesDetection Method: Chemiluminescence, Exposure Time: 30 seconds, Specific Bands: ~70 kD? kDa


CommentsWorks very well with chemiluminescent detection, but not quite strong enough for a good signal with colorimetric detection. Overall good! Appears slightly smaller than normal, although this can happen in my particular species. Only band observed on blot.

Product General Protocols

Video Protocols

WB Video Protocol
ChIP Video Protocol
ChIP Webinar
ICC/IF Video Protocol

FAQs for TLR4 Antibody (NB100-56566). (Showing 1 - 5 of 5 FAQs).

  1. I want to check the TLR4 expression on Swine embryonic fibroblast cells. Is it applicable to use this human TLR4 antibody? Have you obtained any results on swine cells using this TLR4 antibody.
    • This antibody has not been used on swine however I have carried out a blast and the % homology is 73% between the human protein and the pig protein. If you would be interested in testing this novel species, please take a look at our Innovators Reward Program.
  2. Do you know the amino acid sequence against which this antibody is directed to? Also, what isoform of the protein would it be recognizing, or from what specific TLR4 transcript?
    • This antibody binds within amino acids 100-200 of TLR4. This antibody will recognize isoforms 1 and 2 of TLR4 as this region is present in both of these isoforms, but not isoform 3, according to UniProt O00206.
  3. Would you be able to share the sequence homology/alignment of the immunogen sequence of NB100-56566 to the Zebrafish protein (Uniprot S5Q1H4)?
    • We ran the sequence you provided against the immunogen, and unfortunately, there is only a 28% homology.
  4. I would like to use this antibody but it has not been validated in my species of interest. Is there any way I can find out if it will work?
    • We offer risk-free testing of all of our primary antibodies. Please check out our Innovator's Reward Program and test this TLR4 antibody in any unvalidated species or application, without the financial risk of failure.
  5. How do I choose secondary antibodies to label the same cells when I have two primary antibodies from the same host?
    • Use isotype-specific secondary antibodies if the primary antibodies are of different isotypes. You can also make direct conjugates of the primary antibodies by use of antibody labeling kits, dyes, or custom conjugations (please contact Technical Support for custom orders).

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-27149AF350
Alexa Fluor 405 NBP2-27149AF405
Alexa Fluor 488 NBP2-27149AF488
Alexa Fluor 532 NBP2-27149AF532
Alexa Fluor 594 NBP2-27149AF594
Alexa Fluor 647 NBP2-27149AF647
Alexa Fluor 700 NBP2-27149AF700
Alexa Fluor 750 NBP2-27149AF750
Allophycocyanin NBP2-27149APC
Allophycocyanin/Cy7 NB100-56566APCCY7
Biotin NBP2-27149B
DyLight 350 NBP2-27149UV
DyLight 405 NBP2-27149V
DyLight 488 NBP2-27149G
DyLight 550 NBP2-27149R
DyLight 594 NB100-56566DL594
DyLight 650 NBP2-27149C
DyLight 680 NBP2-27149FR
DyLight 755 NBP2-27149IR
FITC NBP2-27149F
HRP NBP2-27149H
Janelia Fluor 549 NB100-56566JF549
Janelia Fluor 646 NB100-56566JF646
PE NBP2-27149PE
PE/Atto594 NB100-56566PEATT594
PE/Cy5.5 NB100-56566PECY55
PE/Cy7 NB100-56566PECY7
PerCP NBP2-27149PCP

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Blogs on TLR4. Showing 1-10 of 11 blog posts - Show all blog posts.

PAMPs and DAMPs: What is the same and what is different about these molecules?
By Victoria OsinskiWhat are PAMPs and DAMPsInflammation results from stimuli signaling damage or infection. The inflammatory response can be beneficial or harmful depending on the type and duration of stimuli. The s...  Read full blog post.

How to identify B cell subsets using flow cytometry
By Victoria OsinskiUsing flow cytometry to identify B cell subsetsIdentifying cellular subsets by flow cytometry requires careful and thorough planning in order to ensure the correct subset of cells are identified a...  Read full blog post.

Lipopolysaccharide from gut microbiome localizes in human atherosclerotic plaques and promotes TLR4-mediated oxidative stress
By Jamshed Arslan, Pharm. D., PhD. Atherosclerosis is a chronic inflammatory condition in which plaques of fats and other substances slowly buildup on the inner walls of arteries to restrict blood flow. In atheroscle...  Read full blog post.

Toll-like receptors in the intestinal epithelial cells
By Jamshed Arslan, Pharm. D., PhD. Toll-like receptors (TLRs) are microbe-sensing proteins that act as first responders to danger signals. TLRs help the intestinal epithelial cells (IECs) recognize commensal bacteria...  Read full blog post.

The role of STING/TMEM173 in gamma and encephalitis Herpes Simplex Virus (HSV)
Stimulator of interferon genes (STING), also known as TMEM173, promotes the production of the interferon’s IFN-alpha and IFN-beta.  STING possesses three functional domains: a cytoplasmic C-terminal tail, a central globular domain, and four N-...  Read full blog post.

TRIF/TICAM1 and mitochondrial dynamics in the innate immune response
TRIF, also known as toll like receptor adaptor molecule 1 or TICAM1, is known for its role in invading foreign pathogens as part of our innate immune response. TRIF/TICAM1 is a TIR-domain adaptor protein (toll/interleukin-1 receptor) that interacts...  Read full blog post.

The role of TLR4 in breast cancer
Toll like receptors (TLRs) are highly conserved proteins that are first known for their role in pathogen recognition and immune response activation.  In order to elicit the necessary immune response in reaction to a foreign pathogen, TLRs trigger cy...  Read full blog post.

cIAP2 - balancing cell death and cell survival
The inhibitor of apoptosis proteins (IAPs) are important regulators of cell death and inflammation. The cellular inhibitor of apoptosis protein 2 (cIAP2) contains three Baculovirus IAP repeat (BIR) domains, a Ubiquitin associated (UBA) domain, and...  Read full blog post.

TLR4 - A Guardian of Innate Immunity
Toll-like receptor 4 (TLR4) belongs to the family of Toll-like receptors (TLR), and plays a main role in pathogen recognition and innate immunity system activation. The TLR family members are highly conserved proteins that all contain a high degree of...  Read full blog post.

IRAK4: The "master IRAK" critical for initiating immune responses
IRAK4, also known as Interleukin-1 receptor-associated kinase 4, is a serine/threonine-protein kinase that plays a critical role in initiating innate and adaptive immune responses against foreign pathogens. It activates NF-kappaB in both Toll-like rec...  Read full blog post.

Showing 1-10 of 11 blog posts - Show all blog posts.

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Recent Reviews


Species: Mouse

Hayk Simonyan
Application: IHC
Species: Mouse

Aileen Keating
Application: WB
Species: Other


Gene Symbol TLR4