CD11b Antibody

Images

 
Immunohistochemistry: CD11b Antibody [NB110-89474] - Staining of mouse pancreas using [NB110-89474] at 1:400 dilution. Nuclei counterstained with 4',6-diamidino-2-phenylindole (DAPI) (blue). Image from product review ...read more
Orthogonal Strategies: Dual RNAscope ISH-IHC: CD11b Antibody [NB110-89474] - Formalin-fixed paraffin-embedded tissue sections of human lymph node were probed for CD11b mRNA (ACD RNAScope Probe, catalog #555098; ...read more
Immunohistochemistry: CD11b Antibody [NB110-89474] - Glibenclamide and Abcc8-/- suppress immune cell infiltration in EAE. White matter of lumbar spinal cord sections from WT control (a), untreated pid-30 WT/EAE (b), ...read more
Flow Cytometry: CD11b Antibody [NB110-89474] - A surface stain was performed on Raw264.7 cells with DyLight 550-conjugated [NB110-89474R] (blue) and a matched isotype control (orange). Cells were incubated in an ...read more
Immunocytochemistry/ Immunofluorescence: CD11b Antibody [NB110-89474] - CD11b antibody [NB110-89474] was tested in Raw264.7 cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with ...read more
Immunohistochemistry: CD11b Antibody [NB110-89474] - Representative photomicrographs of cross sections of uteri collected from wild type (WT) mice 24 h after intrauterine infusion with 100 ul of vehicle or 100 ug ...read more
Simple Western: CD11b Antibody [NB110-89474] - Specific band for Cd11b in 1.0 mg/mL of Dentate Gyrus from Rat Brain. [NB110-89474] was used at a dilution of 1:50. This experiment was performed under reducing conditions ...read more
Western Blot: CD11b Antibody [NB110-89474] - Western Blot detection of CD11b in RAW 264.7 whole cell lysates using [NB110-89474].
Immunohistochemistry-Frozen: CD11b Antibody [NB110-89474] - Immunohistochemical analysis of frozen sections of mouse spleen using [NB110-89474]. Image from verified customer review.
Immunohistochemistry: CD11b Antibody [NB110-89474] - Immunohistochemical analysis of CD11b in human renal cancer with [NB110-89474] using 3,3'-Diaminobenzidine (DAB) with hematoxylin counterstain.

Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, Ce, ChHa, Pm, RMSpecies Glossary
Applications WB, Simple Western, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, ISH, Dual ISH-IHC, Single-Cell Western
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml
Validated by:
       

Orthogonal Strategies

 

Order Details

CD11b Antibody Summary

Immunogen
Rabbit Polyclonal CD11b Antibody was made to a synthetic peptide made to an internal region (within residues 250-350) of the mouse CD11b protein. [Swiss-Prot# P05555]
Localization
Monocytes and granulocytes.
Marker
Microglia Marker, Myeloid Marker
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ITGAM
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 2 ug/mL
  • Simple Western 1:50
  • Flow Cytometry 1:10 - 1:1000
  • Immunocytochemistry/Immunofluorescence 1:200
  • Immunohistochemistry 1:400
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin 1:400
  • In-situ Hybridization
  • Dual RNAscope ISH-IHC
  • Single Cell Western 1:10
Application Notes
This CD11b antibody is useful for WB analysis (PMID 31082627), ICC, Flow Cytometry (PMID 21422470) and IHC-P (PMID 31022918) embedded sections. In WB a specific band is observed ~160 kDa and an apparant non-specific band is observed ~56 kDa. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended. In ICC/IF, membrane staining was observed in Raw 264.7 cells. This antibody does not appear to work in human samples with WB. Use in IHC-Fr and ICC/IF reported in scientific literature (PMID 23980916). The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. Use in In-situ Hybridization reported in scientific literature (PMID: 27133471).
Theoretical MW
127.2 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control
Raw 264.7 Whole Cell Lysate
Reviewed Applications
Read 11 Reviews rated 4.5
using
NB110-89474 in the following applications:

Publications
Read Publications using
NB110-89474 in the following applications:

Reactivity Notes

Monkey reactivity reported in scientific literature (PMID: 26443820). Rhesus Macaque reactivity reported in scientific literature (PMID: 29760177). Use in C. elegans reported in scientific literature (PMID:32058942).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CD11b Antibody

  • antigen CD11b (p170)
  • CD11 antigen-like family member B
  • CD11b antigen
  • CD11b
  • Cell surface glycoprotein MAC-1 subunit alpha
  • Complement component 3 receptor 3 subunit
  • CR-3 alpha chain
  • CR3A
  • CR3AMGC117044
  • Integrin alpha M
  • integrin alpha-M
  • integrin, alpha M (complement component 3 receptor 3 subunit)
  • ITGAM
  • Leukocyte adhesion receptor MO1
  • MAC 1
  • MAC1
  • MAC-1
  • Mac1, alpha subunit
  • MAC1A
  • Mac-1a
  • macrophage antigen alpha polypeptide
  • Mo1, alpha subunit
  • MO1A
  • neutrophil adherence receptor alpha-M subunit
  • Neutrophil adherence receptor
  • SLEB6

Background

CD11b (integrin alpha M subunit) is a type I transmembrane glycoprotein. CD11b combines with the Integrin beta 2 subunit (CD18) to form the non-covalent heterodimer Integrin alpha M/beta 2, also known as Mac-1 and complement receptor type 3 (CR3). The CD11b/CD18 (Mac-1) heterodimer has a theoretical molecular weight of 127kDa but is often observed near 170kDa due to post translational modifications. Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix. Integrins have diverse roles in several biological processes, including cell migration during development, wound healing, cell differentiation, and apoptosis. The particular integrin CD11b is known as a pro-inflammatory molecule given its ability to promote phagocyte cytotoxic functions while enhancing several effector molecules such as FcGR, uPAR, and CD14 (1). In macrophages, CpG-DNA stimulates lysosomal degradation and vacuolar acidification, subsequently promoting CD11b release via TLR9 (2). During an acute infection, high CD11b/Mac-1 expression on antigen-specific CD8 (+) T cells can signify recent activation of the immune system, whereas naive T cells and virus-specific memory CD8 (+) T cells express little or no Mac-1 when exposed to a virus (3). Variations at the ITGAM gene, which encodes for the CD11b chain of the Mac-1 integrin, is one of the main genetic risk factors involved in systemic lupus erythematosus /SLE disorder (4).

References

1. Rosetti, F., & Mayadas, T. N. (2016). The many faces of Mac-1 in autoimmune disease. Immunol Rev, 269(1), 175-193. doi:10.1111/imr.12373

2. Kim, D., Kim, T. H., Wu, G., Park, B. K., Ha, J. H., Kim, Y. S.,... Kwon, H. J. (2016). Extracellular Release of CD11b by TLR9 Stimulation in Macrophages. PLoS One, 11(3), e0150677. doi:10.1371/journal.pone.0150677

3. Christensen, J. E., Andreasen, S. O., Christensen, J. P., & Thomsen, A. R. (2001). CD11b expression as a marker to distinguish between recently activated effector CD8(+) T cells and memory cells. Int Immunol, 13(4), 593-600. doi:10.1093/intimm/13.4.593

4. Nath, S. K., Han, S., Kim-Howard, X., Kelly, J. A., Viswanathan, P., Gilkeson, G. S.,... Harley, J. B. (2008). A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. Nat Genet, 40(2), 152-154. doi:10.1038/ng.71

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CD11b Antibody (NB110-89474)(61)

We have publications tested in 7 confirmed species: Human, Mouse, Rat, C. elegans, Chinese Hamster, Monkey, Rhesus Macaque.

We have publications tested in 8 applications: Dual ISH-IHC, Flow, ICC/IF, IF, IHC, IHC-Fr, IHC-P, WB.


Filter By Application
Dual ISH-IHC
(1)
Flow
(1)
ICC/IF
(14)
IF
(1)
IHC
(12)
IHC-Fr
(5)
IHC-P
(8)
WB
(13)
All Applications
Filter By Species
Human
(12)
Mouse
(36)
Rat
(8)
C. elegans
(1)
Chinese Hamster
(1)
Monkey
(1)
Rhesus Macaque
(1)
All Species
Showing Publications 1 - 10 of 61. Show All 61 Publications.
Publications using NB110-89474 Applications Species
Chen Q, Liu J, Sawada T et al. Possible role of EphA4 and VEGFR2 interactions in neural stem and progenitor cell differentiation Exp Ther Med Jan 3 2020 [PMID: 32104234] (ICC/IF, Mouse) ICC/IF Mouse
Yew M, Koh R, Chye S et al. Edible birds nest improves motor behavior and protects dopaminergic neuron against oxidative and nitrosative stress in Parkinsons disease mouse model Journal of Functional Foods Sep 1 2018 (IHC, Mouse) IHC Mouse
Lerbs T, Cui L, King M et al. CD47 prevents the elimination of diseased fibroblasts in scleroderma bioRxiv Jun 7 2020 (IHC, Human) IHC Human
Kuziel G, Thompson V, D'Amato JV, Arendt LM Stromal CCL2 Signaling Promotes Mammary Tumor Fibrosis through Recruitment of Myeloid-Lineage Cells Cancers (Basel) Jul 28 2020 [PMID: 32731354] (IHC, Mouse) IHC Mouse
Goldsmith JR, Spitofsky N, Zamani A et al. TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling Nat Commun May 22 2020 [PMID: 32444641] (ICC/IF, Mouse) ICC/IF Mouse
Wu My, Liu L, Wang Ej et Al. PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation Autophagy Mar 19 2020 [PMID: 32160108] (IF, Mouse) IF Mouse
Zou D, Pei J, Lan J et al. A SNP of bacterial blc disturbs gut lysophospholipid homeostasis and induces inflammation through epithelial barrier disruption EBioMedicine Feb 12 2020 [PMID: 32058942] (IHC-P, C. elegans) IHC-P C. elegans
GUlcUler Balta GS, Monzel C, Kleber S et al. 3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival Cell Rep Nov 19 2019 [PMID: 31747602] (ICC/IF, Mouse) ICC/IF Mouse
Xu Y, Du X, Turner N et al. Enhanced acyl-CoA: cholesterol acyltransferase activity increases cholesterol levels on the lipid dropletsurface and impairs adipocyte function J. Biol. Chem. Nov 14 2019 [PMID: 31727739] (WB, Mouse) WB Mouse
Szabo R, Callies LK, Bugge TH Matriptase drives early-onset intestinal failure in a mouse model of congenital tufting enteropathy Development Oct 18 2019 [PMID: 31628112]
Show All 61 Publications.

Reviews for CD11b Antibody (NB110-89474) (11) 4.511

Average Rating: 4.5
(Based on 11 reviews)
We have 11 reviews tested in 2 species: Human, Mouse.

Reviews using NB110-89474:
Filter by Applications
WB
(5)
IHC-Fr
(3)
IHC-P
(1)
IF
(2)
All Applications
Filter by Species
Human
(2)
Mouse
(8)
All Species
Images Ratings Applications Species Date Details
Western Blot CD11b NB110-89474
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5
reviewed by:
Anonymous
WB Mouse 05/03/2020
View

Summary

ApplicationWestern Blot
Sample TestedB cell enriched peripheral blood mononuclear cells (PBMC)
SpeciesMouse
LotY-5
Western Blot CD11b NB110-89474
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3
reviewed by:
Anonymous
WB Mouse 12/27/2019
View

Summary

ApplicationWestern Blot
Sample TestedHepa 1-6 mouse hepatoma cell line
SpeciesMouse
LotY-5
Western Blot CD11b NB110-89474
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3
reviewed by:
Anonymous
WB Mouse 11/30/2018
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Summary

ApplicationWestern Blot
Sample TestedAdult mouse brain tissue
SpeciesMouse
LotY-7
Western Blot CD11b NB110-89474
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5
reviewed by:
Anonymous
WB Human 10/28/2018
View

Summary

ApplicationWestern Blot
Sample TestedJurkat and THP1 cells
SpeciesHuman
LotY-5
Immunohistochemistry-Frozen CD11b NB110-89474
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5
reviewed by:
Sasan Jalili
IHC-Fr Mouse 05/12/2018
View

Summary

ApplicationImmunohistochemistry-Frozen
Sample TestedFrozen mouse spleen
SpeciesMouse
LotNB110-89474
Immunohistochemistry-Frozen CD11b NB110-89474
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5
reviewed by:
James Xiao
IHC-Fr Human 02/22/2018
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Summary

ApplicationImmunohistochemistry-Frozen
Sample TestedHuman lung graft
SpeciesHuman
LotY-2

Comments

CommentsHuman lung tissue was stained with CD11b.
Primary antibody (1:100) was diluted in a blocking buffer (PBS with 0.5%). A secondary Alexa647-conjugated Goat anti-Rabbit antibody (1:400) was used to detect CD11b.
Immunohistochemistry-Frozen CD11b NB110-89474
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4
reviewed by:
James Xiao
IHC-Fr Mouse 02/22/2018
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Summary

ApplicationImmunohistochemistry-Frozen
Sample TestedLung graft,IL1b-KO monocyte treated lung
SpeciesMouse
LotY-2

Comments

CommentsLung collected from an IL1b-KO monocytes-treated recipient was stained with CD11b.
Primary antibody (1:100) was diluted in a blocking buffer (PBS with 0.5%). A secondary Alexa647-conjugated Goat anti-Rabbit antibody (1:400) was used to detect CD11b.
Immunohistochemistry-Paraffin CD11b NB110-89474
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5
reviewed by:
Anonymous
IHC-P Mouse 09/15/2017
View

Summary

ApplicationImmunohistochemistry-Paraffin
Sample TestedMouse spleen cells
SpeciesMouse
LotX-8

Comments

CommentsPermeabillized with 3% Triton-X100
Antigen Retrieval with Citrate buffer, 20 min, 90C
1st ab dilution: 1:200
Immunofluorescence CD11b NB110-89474
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5
reviewed by:
Anonymous
IF Mouse 11/29/2016
View

Summary

ApplicationImmunofluorescence
Sample Testedcardiac tissue
SpeciesMouse

Comments

CommentsIn order to visualize staining the secondary method was used. Blocking was performed in goat serum and secondary antibodies used were Alexa Fluor 488 conjugate.
Western Blot CD11b NB110-89474
Enlarge
5
reviewed by:
Anonymous
WB 01/21/2015
View

Summary

ApplicationWestern Blot
Immunofluorescence CD11b NB110-89474
Enlarge
5
reviewed by:
Dawn Jaquish
IF Mouse 03/05/2013
View

Summary

ApplicationImmunofluorescence
Sample TestedMouse Pancreas
SpeciesMouse
CommentsThe antibody worked well at the recommended dilution for our research

Blocking

Blocking Details10% Goat serum + 5% BSA in TBS-T for 1 hr at RT. I also labeled for the nuclei with DAPI by 5min at RT in TBS

Primary Anitbody

Dilution RatioAntibody used at 1:400 dilution overnight at 4oC in TBS-T

Secondary Antibody

Secondary DescriptionGoat anti Rabbit Alexa 594
Secondary Manufacturer Cat#Invitrogen
Secondary Concentration1:500 Dilution

Details

Detection NotesDetection of signal was done by fluorescence and the negative control was normal rabbit IgG at the same concentration
Fixation DetailsFixed overnight with 10% NBF. Antigen Retrieval done for 20 min.
Wash Description3X 5min washes in TBS-T

Comments

CommentsThe antibody worked well at the recommended dilution for our research

Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for CD11b Antibody (NB110-89474). (Showing 1 - 8 of 8 FAQs).

  1. I am looking for a Mac-1 (microglia cell marker) antibody to do immunostaining with my mouse brain and I checked, you have a lot of antibodies for this biomarker. I don't know which one is the best to be used for immunohistology on mouse brain tissue. Could you please help with this?
    • I would recommend NB110-89474. This antibody has been published in 11 scientific articles, including several times in IHC in mouse. As long as CD11b is expressed in your sample, it should work just fine and is backed by our 100% Novus Guarantee.
  2. What types of cells can this CD11b antibody be used as a marker for?
    • A study used this CD11b antibody to stain granulocytes in mouse uterine tissue in IHC. CD11b is also expressed on other leukocytes such as monocytes, macrophages, and natural killer cells.
  3. Do you know if this CD11b antibody can be used in CD11b positive cell depletion? 
    • This particular CD11b antibody is not reccomended for depletion studies due to the preservative used; however, our CD11b antibody NBP1-06650 is offered in a preservative free format and has been validated for blocking.
  4. Looking for a bone marrow macrophage marker can you recommend a CD11b antibody for ICC?
    • I would recommend NB110-89474 which is our most popular CD11b antibody and has been validated in ICC and cited in 18 publications.
  5. We need a CD11b antibody for IHC-P on mouse tissue conjugated to FITC, do you have one that will work?
    • We have 3 CD11b antibodies for IHC-P and just one CD11 b antibody we offer conjugated to FITC, NB110-89474F.
  6. The protocol says to do enzymatic antigen retrieval before incubating with the CD11b antibody, which enzyme is used?
    • The protocol is referencting the PIER method using Proteinase K as the enzyme.
  7. I'm not sure if this will work for me, can I get a free sample of your CD11b antibody to test?
    • We don't offer free samples but we do offer this CD11b antibody in a trial size of 0.025 ml at a reduced cost, all antibodies are backed by our 100% guarantee to work in all validated species and applications on the product's web page.
  8. Is CD11b antibody also staining neutrophils in the brain
    • CD11b is typically used as a marker for granulocytes and macrophages. You may need a combination of markers to specifically identify neutrophils

Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NB110-89474AF350
Alexa Fluor 405 NB110-89474AF405
Alexa Fluor 488 NB110-89474AF488
Alexa Fluor 532 NB110-89474AF532
Alexa Fluor 594 NB110-89474AF594
Alexa Fluor 647 NB110-89474AF647
Alexa Fluor 700 NB110-89474AF700
Alexa Fluor 750 NB110-89474AF750
Allophycocyanin/Cy7 NB110-89474APCCY7
Biotin NB110-89474B
DyLight 350 NB110-89474UV
DyLight 405 NB110-89474V
DyLight 488 NB110-89474G
DyLight 550 NB110-89474R
DyLight 650 NB110-89474C
DyLight 680 NB110-89474FR
DyLight 755 NB110-89474IR
FITC NB110-89474F
HRP NB110-89474H
Janelia Fluor 549 NB110-89474JF549
Janelia Fluor 646 NB110-89474JF646
PE NB110-89474PE
PE/Atto594 NB110-89474PEATT594
PE/Cy5.5 NB110-89474PECY55
PE/Cy7 NB110-89474PECY7

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Blogs on CD11b.

Gut-brain axis: microbiota influence behavior and mental well-being
By Jennifer Sokolowski, MD, PhD.Gut-microbiome interactionsOn and in our bodies, microbes outnumber our cells by about ten-to-one. Studies have revealed that the microbiome influences neurogenesis, cognition, and...  Read full blog post.

Antibody treatment can generate microglia-like cells from bone marrow
By Jennifer Sokolowski, MD, PhD.Microglia play important roles in the brain in both homeostatic and pathological conditions, acting to clear debris and dying cells. There is evidence to suggest that microglial dys...  Read full blog post.

TMEM 119 is a specific marker of microglia cells
By Jennifer Sokolowski, MD, PhD.Microglia are a major immune-cell component in the brain. They ingest and degrade dead cells, debris, and foreign material and interact with other immune cells to orchestrate centra...  Read full blog post.

Topics in CD11b: The innate immune response
Integrins are transmembrane receptors composed of alpha and beta chains, where beta-integrins are mainly expressed in leukocytes. Leukocytes are white blood cells that act in the immune system to defend our body against foreign pathogens.  Integrin...  Read full blog post.

CD11b - More than a microglial marker
The protein CD11b has been implicated in the various adhesion-related interactions of cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. It is part of a heterodimer that consists of CD11b and CD18. It also modulates the...  Read full blog post.

CD11b: Marker for a New Type of B Cell that Participates in Cell-Mediated Immunity
Think B lymphocytes just produce antibodies? Think again! Although, of course, B cells are vital for the humoral immune response, many studies in recent years have begun to uncover antibody-independent actions of B cells: regulating T cells and thus a...  Read full blog post.

Adhesion Receptor Molecule CD11b/c is the Point of Entry for many Infectious Diseases
Pathogenic microorganisms utilize a variety of cell surface receptors to gain entry into host cells and to bypass the natural defense mechanisms. One of the most prominent receptors used in this fashion is the leukocyte adhesion receptor CD11b/c. This...  Read full blog post.

CD11b/CD18 and Neutrophil-Epithelial Interactions as Targets for Anti-Inflammatory Therapies
The beta-2 integrins, a family of four cell surface transmembrane glycoproteins expressed only on leukocytes, include CD11a/CD18, CD11b/CD18, CD11c/CD18, and CD11d/CD18. They consist of a common beta subunit (CD18) and homologous alpha subunits (CD11a...  Read full blog post.

The CD11b Antibody: A Marker for Microglial Cells
Microglia are the resident macrophages of the central nervous system, and the first line of immune defense. Pioneering antibody research in the 1990's identified the Integrin beta 2 protein (also called ITGB2, complement receptor 3, CR3, CD18, and Mac...  Read full blog post.

CD11b Expression, Leukocyte Adhesion and the Innate Immune System
CD11b is an integrin family member which pairs with CD18 to form the CR3 heterodimer. CD11b is expressed on the surface of many leukocytes including monocytes, neutrophils, natural killer cells, granulocytes and macrophages, as well as on 8% of spleen...  Read full blog post.

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Recent Reviews

4.5
5
8
4
1
3
2
2
0
1
0

Anonymous
05/03/2020
Application: WB
Species: Mouse

Anonymous
12/27/2019
Application: WB
Species: Mouse

Anonymous
11/30/2018
Application: WB
Species: Mouse

Bioinformatics

Gene Symbol ITGAM
Entrez
Uniprot