CD11b Antibody - BSA Free

Images

 
Immunocytochemistry/ Immunofluorescence: CD11b Antibody [NB110-89474] - Staining of mouse pancreas using [NB110-89474] at 1:400 dilution. Nuclei counterstained with 4',6-diamidino-2-phenylindole (DAPI) (blue). ICC/IF ...read more
Orthogonal Strategies: Dual RNAscope ISH-IHC: CD11b Antibody [NB110-89474] - Formalin-fixed paraffin-embedded tissue sections of human lymph node were probed for CD11b mRNA (ACD RNAScope Probe, catalog #555098; ...read more
Immunohistochemistry: CD11b Antibody [NB110-89474] - Glibenclamide and Abcc8-/- suppress immune cell infiltration in EAE. White matter of lumbar spinal cord sections from WT control (a), untreated pid-30 WT/EAE (b), ...read more
Flow Cytometry: CD11b Antibody [NB110-89474] - A surface stain was performed on Raw264.7 cells with DyLight 550-conjugated [NB110-89474R] (blue) and a matched isotype control (orange). Cells were incubated in an ...read more
Immunocytochemistry/ Immunofluorescence: CD11b Antibody - BSA Free [NB110-89474] - Raw264.7 cells were fixed in 4% paraformaldehyde for 10 minutes and permeabilized in 0.05% Triton X-100 in PBS for 5 minutes. The cells ...read more
Immunohistochemistry: CD11b Antibody [NB110-89474] - Representative photomicrographs of cross sections of uteri collected from wild type (WT) mice 24 h after intrauterine infusion with 100 ul of vehicle or 100 ug ...read more
Simple Western: CD11b Antibody [NB110-89474] - Specific band for Cd11b in 1.0 mg/mL of Dentate Gyrus from Rat Brain. [NB110-89474] was used at a dilution of 1:50. This experiment was performed under reducing conditions ...read more
Western Blot: CD11b Antibody [NB110-89474] - Western Blot detection of CD11b in RAW 264.7 whole cell lysates using [NB110-89474].
Immunohistochemistry-Frozen: CD11b Antibody [NB110-89474] - Immunohistochemical analysis of frozen sections of mouse spleen using [NB110-89474]. IHC-Fr image submitted by a verified customer review.
Immunocytochemistry/ Immunofluorescence: CD11b Antibody - BSA Free [NB110-89474] - Raw264.7 cells were fixed in 4% paraformaldehyde for 10 minutes and permeabilized in 0.05% Triton X-100 in PBS for 5 minutes. The cells ...read more
Flow Cytometry: CD11b Antibody - BSA Free [NB110-89474] - An intracellular stain was performed on THP-1 cells with CD11b NB110-89474 (blue) and a matched isotype control NBP2-24891 (orange). Cells were incubated in an ...read more
Immunocytochemistry/ Immunofluorescence: CD11b Antibody - BSA Free [NB110-89474] - CD11b Antibody [NB110-89474] - CD11b antibody [NB110-89474] was tested in Raw264.7 cells with DyLight 488 (green). Nuclei and ...read more
Immunocytochemistry/ Immunofluorescence: CD11b Antibody - BSA Free [NB110-89474] - Raw264.7 cells were fixed in 4% paraformaldehyde for 10 minutes and permeabilized in 0.05% Triton X-100 in PBS for 5 minutes. The cells ...read more
Immunocytochemistry/ Immunofluorescence: CD11b Antibody - BSA Free [NB110-89474] - Raw264.7 cells were fixed in 4% paraformaldehyde for 10 minutes and permeabilized in 0.05% Triton X-100 in PBS for 5 minutes. The cells ...read more
Immunohistochemistry: CD11b Antibody [NB110-89474] - Immunohistochemical analysis of CD11b in human renal cancer with [NB110-89474] using 3,3'-Diaminobenzidine (DAB) with hematoxylin counterstain.
Dual RNAscope ISH-IHC: CD11b Antibody [NB110-89474] - CD14 mRNA (red) and CD11b protein (green) were detected in formalin-fixed paraffin-embedded tissue sections of human malignant lymph node. ACD's Integrated ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, Ce, ChHa, Pm, RMSpecies Glossary
Applications WB, Simple Western, Flow-CS, ICC/IF, IHC, IHC-Fr, IHC-P, ISH, Dual ISH-IHC, Single-Cell Western
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Format
BSA Free
Concentration
1 mg/ml
Validated by:
       

Orthogonal Strategies

 

Order Details

CD11b Antibody - BSA Free Summary

Immunogen
Rabbit Polyclonal CD11b Antibody was made to a synthetic peptide within residues 250-350 of the mouse CD11b protein. [Swiss-Prot# P05555]
Localization
Monocytes and granulocytes.
Marker
Microglia Marker, Myeloid Marker
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ITGAM
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Dual RNAscope ISH-IHC
  • Flow (Cell Surface) 1:10 - 1:1000
  • Immunocytochemistry/Immunofluorescence 1:200
  • Immunohistochemistry 1:400
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin 1:400
  • In-situ Hybridization
  • Simple Western 1:50
  • Single Cell Western 1:10
  • Western Blot 2 ug/mL
Application Notes
This CD11b antibody is useful for WB analysis (PMID 31082627), ICC, Flow Cytometry (PMID 21422470) and IHC-P (PMID 31022918) embedded sections. In WB a specific band is observed ~160 kDa and an apparant non-specific band is observed ~56 kDa. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended. In ICC/IF, membrane staining was observed in Raw 264.7 cells. This antibody does not appear to work in human samples with WB. Use in IHC-Fr and ICC/IF reported in scientific literature (PMID: 23980916). The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. Use in In-situ Hybridization reported in scientific literature (PMID: 27133471).
Theoretical MW
127.2 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control
Raw 264.7 Whole Cell Lysate
Reviewed Applications
Read 12 Reviews rated 4.5
using
NB110-89474 in the following applications:

Publications
Read Publications using
NB110-89474 in the following applications:

Reactivity Notes

Use in Mouse reported in scientific literature (PMID:35398596).Monkey reactivity reported in scientific literature (PMID: 26443820). Rhesus Macaque reactivity reported in scientific literature (PMID: 29760177). Use in C. elegans reported in scientific literature (PMID:32058942).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CD11b Antibody - BSA Free

  • antigen CD11b (p170)
  • CD11 antigen-like family member B
  • CD11b antigen
  • CD11b
  • Cell surface glycoprotein MAC-1 subunit alpha
  • Complement component 3 receptor 3 subunit
  • CR-3 alpha chain
  • CR3A
  • CR3AMGC117044
  • Integrin alpha M
  • integrin alpha-M
  • integrin, alpha M (complement component 3 receptor 3 subunit)
  • ITGAM
  • Leukocyte adhesion receptor MO1
  • MAC 1
  • MAC1
  • MAC-1
  • Mac1, alpha subunit
  • MAC1A
  • Mac-1a
  • macrophage antigen alpha polypeptide
  • Mo1, alpha subunit
  • MO1A
  • neutrophil adherence receptor alpha-M subunit
  • Neutrophil adherence receptor
  • SLEB6

Background

CD11b (integrin alpha M subunit) is a type I transmembrane glycoprotein. CD11b combines with the Integrin beta 2 subunit (CD18) to form the non-covalent heterodimer Integrin alpha M/beta 2, also known as Mac-1 and complement receptor type 3 (CR3). The CD11b/CD18 (Mac-1) heterodimer has a theoretical molecular weight of 127kDa but is often observed near 170kDa due to post translational modifications. Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix. Integrins have diverse roles in several biological processes, including cell migration during development, wound healing, cell differentiation, and apoptosis. The particular integrin CD11b is known as a pro-inflammatory molecule given its ability to promote phagocyte cytotoxic functions while enhancing several effector molecules such as FcGR, uPAR, and CD14 (1). In macrophages, CpG-DNA stimulates lysosomal degradation and vacuolar acidification, subsequently promoting CD11b release via TLR9 (2). During an acute infection, high CD11b/Mac-1 expression on antigen-specific CD8 (+) T cells can signify recent activation of the immune system, whereas naive T cells and virus-specific memory CD8 (+) T cells express little or no Mac-1 when exposed to a virus (3). Variations at the ITGAM gene, which encodes for the CD11b chain of the Mac-1 integrin, is one of the main genetic risk factors involved in systemic lupus erythematosus /SLE disorder (4).

References

1. Rosetti, F., & Mayadas, T. N. (2016). The many faces of Mac-1 in autoimmune disease. Immunol Rev, 269(1), 175-193. doi:10.1111/imr.12373

2. Kim, D., Kim, T. H., Wu, G., Park, B. K., Ha, J. H., Kim, Y. S., . . . Kwon, H. J. (2016). Extracellular Release of CD11b by TLR9 Stimulation in Macrophages. PLoS One, 11(3), e0150677. doi:10.1371/journal.pone.0150677

3. Christensen, J. E., Andreasen, S. O., Christensen, J. P., & Thomsen, A. R. (2001). CD11b expression as a marker to distinguish between recently activated effector CD8(+) T cells and memory cells. Int Immunol, 13(4), 593-600. doi:10.1093/intimm/13.4.593

4. Nath, S. K., Han, S., Kim-Howard, X., Kelly, J. A., Viswanathan, P., Gilkeson, G. S., . . . Harley, J. B. (2008). A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. Nat Genet, 40(2), 152-154. doi:10.1038/ng.71

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CD11b Antibody (NB110-89474)(79)

We have publications tested in 7 confirmed species: Human, Mouse, Rat, C. elegans, Chinese Hamster, Monkey, Rhesus Macaque.

We have publications tested in 8 applications: Dual ISH-IHC, Flow, ICC/IF, IF, IHC, IHC-Fr, IHC-P, WB.


Filter By Application
Dual ISH-IHC
(1)
Flow
(4)
ICC/IF
(15)
IF
(1)
IHC
(16)
IHC-Fr
(5)
IHC-P
(10)
WB
(17)
All Applications
Filter By Species
Human
(14)
Mouse
(45)
Rat
(10)
C. elegans
(1)
Chinese Hamster
(1)
Monkey
(1)
Rhesus Macaque
(1)
All Species
Showing Publications 1 - 10 of 79. Show All 79 Publications.
Publications using NB110-89474 Applications Species
Singh, AK;Wang, R;Lombardo, KA;Praharaj, M;Bullen, CK;Um, P;Davis, S;Komm, O;Illei, PB;Ordonez, AA;Bahr, M;Huang, J;Gupta, A;Psoter, KJ;Jain, SK;Bivalacqua, TJ;Yegnasubramanian, S;Bishai, WR; Dynamic single-cell RNA sequencing reveals BCG vaccination curtails SARS-CoV-2 induced disease severity and lung inflammation bioRxiv : the preprint server for biology [PMID: 35313583] (Flow) Flow
Cha JH, Chan LC, Wang YN et al. Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer The Journal of biological chemistry Mar 9 2022 [PMID: 35278434] (IHC, Mouse) IHC Mouse
Makwana O, Smith GA, Flockton HE et al. Impact of cigarette versus electronic cigarette aerosol conditioned media on aortic endothelial cells in a microfluidic cardiovascular model Scientific reports Feb 26 2021 [PMID: 33637800] (ICC/IF, Human) ICC/IF Human
Lerbs T, Cui L, King M et al. CD47 prevents the elimination of diseased fibroblasts in scleroderma bioRxiv Jun 7 2020 (IHC, Human) IHC Human
Trappetti V, Fazzari J, Fernandez-Palomo C et al. Targeted Accumulation of Macrophages Induced by Microbeam Irradiation in a Tissue-Dependent Manner Biomedicines Mar 22 2022 [PMID: 35453485] (IHC-P, Mouse) IHC-P Mouse
Huda N, Khambu B, Liu G et al. Senescence Connects Autophagy Deficiency to Inflammation and Tumor Progression in the Liver Cellular and molecular gastroenterology and hepatology Apr 8 2022 [PMID: 35398596] (IHC, Mouse) IHC Mouse
Sojoodi M, Erstad DJ, Barrett SC et al. Peroxidasin deficiency re-programs macrophages toward pro-fibrolysis function and promotes collagen resolution in liver Cellular and molecular gastroenterology and hepatology Jan 27 2022 [PMID: 35093588] (IHC-P, Mouse) IHC-P Mouse
Guo ML, Chivero ET, Callen SE, Buch S NLRP3 Inflammasome Is Involved in Cocaine-Mediated Potentiation on Behavioral Changes in CX3CR1-Deficient Mice Journal of personalized medicine Sep 27 2021 [PMID: 34683104] (WB, Mouse) WB Mouse
Chivero ET, Sil S, Singh S Et al. Protective Role of Lactobacillus rhamnosus Probiotic in Reversing Cocaine-Induced Oxidative Stress, Glial Activation and Locomotion in Mice Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Oct 9 2021 [PMID: 34628571]
Jalloh A, Flowers A, Hudson C et al. Polyphenol Supplementation Reverses Age-Related Changes in Microglial Signaling Cascades International Journal of Molecular Sciences Jun 14 2021 [PMID: 34198710] (WB, Rat) WB Rat
Show All 79 Publications.

Reviews for CD11b Antibody (NB110-89474) (12) 4.512

Average Rating: 4.5
(Based on 12 reviews)
We have 12 reviews tested in 2 species: Human, Mouse.

Reviews using NB110-89474:
Filter by Applications
Immunocytochemistry
(1)
Western Blot
(5)
Immunohistochemistry-Frozen
(3)
Immunohistochemistry-Paraffin
(1)
Immunofluorescence
(2)
All Applications
Filter by Species
Human
(3)
Mouse
(8)
All Species
Images Ratings Applications Species Date Details
Immunocytochemistry CD11b NB110-89474
Enlarge
4
reviewed by:
Lucia Lisi
Immunocytochemistry Human 05/20/2021
View

Summary

ApplicationImmunocytochemistry
Sample TestedHuman microglia
SpeciesHuman
LotAA
Western Blot CD11b NB110-89474
Enlarge
5
reviewed by:
Lei Nie
Western Blot Mouse 05/03/2020
View

Summary

ApplicationWestern Blot
Sample TestedB cell enriched peripheral blood mononuclear cells (PBMC)
SpeciesMouse
LotY-5
Western Blot CD11b NB110-89474
Enlarge
3
reviewed by:
Xianghou Xia
Western Blot Mouse 12/27/2019
View

Summary

ApplicationWestern Blot
Sample TestedHepa 1-6 mouse hepatoma cell line
SpeciesMouse
LotY-5
  3
reviewed by:
Sheela Kadapakkam
Western Blot Mouse 11/30/2018
View

Summary

ApplicationWestern Blot
Sample TestedAdult mouse brain tissue
SpeciesMouse
LotY-7
Western Blot CD11b NB110-89474
Enlarge
5
reviewed by:
Junwei HOU
Western Blot Human 10/28/2018
View

Summary

ApplicationWestern Blot
Sample TestedJurkat and THP1 cells
SpeciesHuman
LotY-5
Immunohistochemistry-Frozen CD11b NB110-89474
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5
reviewed by:
Verified Customer
Immunohistochemistry-Frozen Mouse 05/12/2018
View

Summary

ApplicationImmunohistochemistry-Frozen
Sample TestedFrozen mouse spleen
SpeciesMouse
LotNB110-89474
Immunohistochemistry-Frozen CD11b NB110-89474
Enlarge
5
reviewed by:
Verified Customer
Immunohistochemistry-Frozen Human 02/22/2018
View

Summary

ApplicationImmunohistochemistry-Frozen
Sample TestedHuman lung graft
SpeciesHuman
LotY-2

Comments

CommentsHuman lung tissue was stained with CD11b.
Primary antibody (1:100) was diluted in a blocking buffer (PBS with 0.5%). A secondary Alexa647-conjugated Goat anti-Rabbit antibody (1:400) was used to detect CD11b.
Immunohistochemistry-Frozen CD11b NB110-89474
Enlarge
4
reviewed by:
Verified Customer
Immunohistochemistry-Frozen Mouse 02/22/2018
View

Summary

ApplicationImmunohistochemistry-Frozen
Sample TestedIL1b-KO monocyte treated lung,Lung graft
SpeciesMouse
LotY-2

Comments

CommentsLung collected from an IL1b-KO monocytes-treated recipient was stained with CD11b.
Primary antibody (1:100) was diluted in a blocking buffer (PBS with 0.5%). A secondary Alexa647-conjugated Goat anti-Rabbit antibody (1:400) was used to detect CD11b.
Immunohistochemistry-Paraffin CD11b NB110-89474
Enlarge
5
reviewed by:
Mozhdeh Sojoodi
Immunohistochemistry-Paraffin Mouse 09/15/2017
View

Summary

ApplicationImmunohistochemistry-Paraffin
Sample TestedMouse spleen cells
SpeciesMouse
LotX-8

Comments

CommentsPermeabillized with 3% Triton-X100
Antigen Retrieval with Citrate buffer, 20 min, 90C
1st ab dilution: 1:200
Immunofluorescence CD11b NB110-89474
Enlarge
5
reviewed by:
Kristine DeLeon-Pennell
Immunofluorescence Mouse 11/29/2016
View

Summary

ApplicationImmunofluorescence
Sample Testedcardiac tissue
SpeciesMouse

Comments

CommentsIn order to visualize staining the secondary method was used. Blocking was performed in goat serum and secondary antibodies used were Alexa Fluor 488 conjugate.
Western Blot CD11b NB110-89474
Enlarge
5
reviewed by:
Bryan Tinsley
Western Blot 01/21/2015
View

Summary

ApplicationWestern Blot
Immunofluorescence CD11b NB110-89474
Enlarge
5
reviewed by:
Verified Customer
Immunofluorescence Mouse 03/05/2013
View

Summary

ApplicationImmunofluorescence
Sample TestedMouse Pancreas
SpeciesMouse

Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for CD11b Antibody (NB110-89474). (Showing 1 - 8 of 8 FAQs).

  1. I am looking for a Mac-1 (microglia cell marker) antibody to do immunostaining with my mouse brain and I checked, you have a lot of antibodies for this biomarker. I don't know which one is the best to be used for immunohistology on mouse brain tissue. Could you please help with this?
    • I would recommend NB110-89474. This antibody has been published in 11 scientific articles, including several times in IHC in mouse. As long as CD11b is expressed in your sample, it should work just fine and is backed by our 100% Novus Guarantee.
  2. What types of cells can this CD11b antibody be used as a marker for?
    • A study used this CD11b antibody to stain granulocytes in mouse uterine tissue in IHC. CD11b is also expressed on other leukocytes such as monocytes, macrophages, and natural killer cells.
  3. Do you know if this CD11b antibody can be used in CD11b positive cell depletion? 
    • This particular CD11b antibody is not reccomended for depletion studies due to the preservative used; however, our CD11b antibody NBP1-06650 is offered in a preservative free format and has been validated for blocking.
  4. Looking for a bone marrow macrophage marker can you recommend a CD11b antibody for ICC?
    • I would recommend NB110-89474 which is our most popular CD11b antibody and has been validated in ICC and cited in 18 publications.
  5. We need a CD11b antibody for IHC-P on mouse tissue conjugated to FITC, do you have one that will work?
    • We have 3 CD11b antibodies for IHC-P and just one CD11 b antibody we offer conjugated to FITC, NB110-89474F.
  6. The protocol says to do enzymatic antigen retrieval before incubating with the CD11b antibody, which enzyme is used?
    • The protocol is referencting the PIER method using Proteinase K as the enzyme.
  7. I'm not sure if this will work for me, can I get a free sample of your CD11b antibody to test?
    • We don't offer free samples but we do offer this CD11b antibody in a trial size of 0.025 ml at a reduced cost, all antibodies are backed by our 100% guarantee to work in all validated species and applications on the product's web page.
  8. Is CD11b antibody also staining neutrophils in the brain
    • CD11b is typically used as a marker for granulocytes and macrophages. You may need a combination of markers to specifically identify neutrophils

Control Lysate(s)

Secondary Antibodies

 

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Array NB110-89474

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Blogs on CD11b.


  Read full blog post.

Antibody treatment can generate microglia-like cells from bone marrow
By Jennifer Sokolowski, MD, PhD.Microglia play important roles in the brain in both homeostatic and pathological conditions, acting to clear debris and dying cells. There is evidence to suggest that microglial dys...  Read full blog post.

TMEM 119 is a specific marker of microglia cells
By Jennifer Sokolowski, MD, PhD.Microglia are a major immune-cell component in the brain. They ingest and degrade dead cells, debris, and foreign material and interact with other immune cells to orchestrate centra...  Read full blog post.

Topics in CD11b: The innate immune response
Integrins are transmembrane receptors composed of alpha and beta chains, where beta-integrins are mainly expressed in leukocytes. Leukocytes are white blood cells that act in the immune system to defend our body against foreign pathogens.  Integrin...  Read full blog post.

CD11b - More than a microglial marker
The protein CD11b has been implicated in the various adhesion-related interactions of cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. It is part of a heterodimer that consists of CD11b and CD18. It also modulates the...  Read full blog post.

CD11b: Marker for a New Type of B Cell that Participates in Cell-Mediated Immunity
Think B lymphocytes just produce antibodies? Think again! Although, of course, B cells are vital for the humoral immune response, many studies in recent years have begun to uncover antibody-independent actions of B cells: regulating T cells and thus a...  Read full blog post.

Adhesion Receptor Molecule CD11b/c is the Point of Entry for many Infectious Diseases
Pathogenic microorganisms utilize a variety of cell surface receptors to gain entry into host cells and to bypass the natural defense mechanisms. One of the most prominent receptors used in this fashion is the leukocyte adhesion receptor CD11b/c. This...  Read full blog post.

CD11b/CD18 and Neutrophil-Epithelial Interactions as Targets for Anti-Inflammatory Therapies
The beta-2 integrins, a family of four cell surface transmembrane glycoproteins expressed only on leukocytes, include CD11a/CD18, CD11b/CD18, CD11c/CD18, and CD11d/CD18. They consist of a common beta subunit (CD18) and homologous alpha subunits (CD11a...  Read full blog post.

The CD11b Antibody: A Marker for Microglial Cells
Microglia are the resident macrophages of the central nervous system, and the first line of immune defense. Pioneering antibody research in the 1990's identified the Integrin beta 2 protein (also called ITGB2, complement receptor 3, CR3, CD18, and Mac...  Read full blog post.

CD11b Expression, Leukocyte Adhesion and the Innate Immune System
CD11b is an integrin family member which pairs with CD18 to form the CR3 heterodimer. CD11b is expressed on the surface of many leukocytes including monocytes, neutrophils, natural killer cells, granulocytes and macrophages, as well as on 8% of spleen...  Read full blog post.

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Recent Reviews

4.5
5
8
4
2
3
2
2
0
1
0

Lucia Lisi
05/20/2021
Application: Immunocytochemistry
Species: Human

Lei Nie
05/03/2020
Application: Western Blot
Species: Mouse

Xianghou Xia
12/27/2019
Application: Western Blot
Species: Mouse

Bioinformatics

Gene Symbol ITGAM
Entrez
Uniprot