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uPAR (Urokinase plasminogen activator receptor) is a glycoprotein I anchored surface receptor specific for urokinase plasminogen activator (uPA). Upon binding to uPAR, uPA converts the surface bound, large serum beta globulin plasminogen to plasmin. Plasmin, which is also designated fibrinolysin, is a trypsin-like enzyme that acts on Arg-Lys bonds and induces pericellular proteolysis in fibrin and fibrinogen, and thereby contributes to the systematic activation of the coagulation cascade. uPA and uPAR are known to be overexpressed in mesenchymal and epithelial tumor cells and are required for tumor invasion and metastasis.
|Product By Gene ID
- Monocyte activation antigen Mo3
- CD87 antigen
- UPARurokinase plasminogen activator surface receptor
- u-plasminogen activator receptor form 2
- plasminogen activator, urokinase receptor
Research Areas for uPAR
Find related products by research area and learn more about each of the different research areas below.Cancer
Bioinformatics Tool for uPAR
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