uPAR Products

Description

uPAR (Urokinase plasminogen activator receptor) is a glycoprotein I anchored surface receptor specific for urokinase plasminogen activator (uPA). Upon binding to uPAR, uPA converts the surface bound, large serum beta globulin plasminogen to plasmin. Plasmin, which is also designated fibrinolysin, is a trypsin-like enzyme that acts on Arg-Lys bonds and induces pericellular proteolysis in fibrin and fibrinogen, and thereby contributes to the systematic activation of the coagulation cascade. uPA and uPAR are known to be overexpressed in mesenchymal and epithelial tumor cells and are required for tumor invasion and metastasis.

Bioinformatics

Entrez	18793 Mouse 5329 Human
Uniprot	NM_002659 Human P35456 Mouse
Product By Gene ID	5329
Alternate Names	CD87 antigen CD87 Monocyte activation antigen Mo3 plasminogen activator, urokinase receptor uPAR U-PAR UPARurokinase plasminogen activator surface receptor u-plasminogen activator receptor form 2 URKRMO3

Research Areas for uPAR

Find related products by research area and learn more about each of the different research areas below.

Cancer